LOCUS       NZ_ML123034            24053 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun
            sequence.
ACCESSION   NZ_ML123034
VERSION     NZ_ML123034.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. ADI96-02
  ORGANISM  Streptomyces sp. ADI96-02
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Streptomyces spp. from the marine sponge Antho dichothoma: analyses
            of secondary metabolite biosynthesis gene clusters and some of their
            products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003846185.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 03:48:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,089
            CDSs (total)                      :: 6,032
            Genes (coding)                    :: 5,843
            CDSs (with protein)               :: 5,843
            Genes (RNA)                       :: 57
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 68 of 189
            Pseudo Genes (incomplete)         :: 155 of 189
            Pseudo Genes (internal stop)      :: 10 of 189
            Pseudo Genes (multiple problems)  :: 42 of 189
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1857820
            Orig. end                         :: 1881873
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            ML123034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, Department of
            Pharmacognosy, University of Vienna.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
FEATURES             Location/Qualifiers
     region          1..24053
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iv"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22976
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22976
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12976](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12976)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(59..1339)
                     /locus_tag="EES43_RS08185"
                     /old_locus_tag="EES43_08130"
     CDS             complement(59..1339)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064356.1"
                     /locus_tag="EES43_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08130"
                     /product="MFS transporter"
                     /protein_id="WP_124268113.1"
                     /transl_table=11
                     /translation="MTETTEPPPARRARIFADLTPLRASPDYRRLWFGNTVSWVGQGMT
                     ALAVSLQVYDITGSAFSVGLIGFCSLVPLVVFGLYGGAVADTVDRRRLGLFSASGSFVL
                     SVVLVAATVAGIEQVGLLYAVVALQAVCFALNAPARSSMIARLLPAEQLPAANALNSMT
                     STTGALVGPMLGGLIVGWWGYRAAYTVDAVTFTASLYAMWRLPSMLPDRGEERDPGGKR
                     KRASVLDGLRFLGTRPNLRMTFFTDLAAMVLAHPRALFPVVAVLWYGGDARTTGLLVAA
                     PALGALLGGVFSGWLGRIRRHGLAVLLAVGCWGSAIAVFGLTRQLWLGLLFLALAGCAD
                     TVSMVFRNTMLQAAVPDEMRGRLQGVFIVVVAGGPRLGDFVAGSVADLVSPAVAVTGGG
                     LACVAVVCLLALKWRGFARYDARDPQP"
     gene            complement(1858..3450)
                     /locus_tag="EES43_RS08190"
                     /old_locus_tag="EES43_08135"
     CDS             complement(1858..3450)
                     /NRPS_PKS="Domain: Abhydrolase_1 (90-253). E-value:
                     4.5e-17. Score: 54.4. Matches aSDomain:
                     nrpspksdomains_EES43_RS08190_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718158.1"
                     /locus_tag="EES43_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08135"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_241192349.1"
                     /sec_met_domain="PF00561 (E-value: 6.6e-22, bitscore: 76.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPLVPVLSAPPAGAVPAAGPPTASSPPARNALERYVKQKPRWKR
                     CEADTPAVLQCATIKVPLDYRVPGGKRIDLAISRIKSTAPGKRHGVLLSNPGGPGGQGI
                     DTPLDMRKNLPKAVRQKYDLIGMDPRGVGRSSPVSCGMKPEDENWLRPYKEEAFAKDVA
                     WARDVADKCRAKAGDRLPHITTRNTARDMDLLRAILGETKISFLGYSYGTYLGAVYTQL
                     FPGRADRFVLDSAVDPKRAWRGMIQWWAEGAEPAFDRWTEWAAERSETYKLGATPKQVE
                     RTLWKLVAQADEKPIDVGGQLTTGDDIRSGLRSLVFTPEWATDEVVLLKRAAAGRPTSA
                     RKFAAFAGSAGSGRPGGAEVPSDNARASFFAVVCGDNSAAWSRDPERYRQDAIADKKRY
                     PLFGDMASSIKPCAFWDRSAEPVTKVNNRVGSLVVQNEWDSQTPLPSGQALHAALRGSK
                     MVTVRGGEGHGVYPNGNVCTDGAVNEYLLTGKLPAKDVICRATPKSNEEARKDRKRDAL
                     PGSPLPDRAPDRF"
     aSDomain        complement(2692..3180)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EES43_RS08190_Abhydrolase_1.1"
                     /evalue="4.50E-17"
                     /label="EES43_RS08190_Abhydrolase_1.1"
                     /locus_tag="EES43_RS08190"
                     /protein_end="253"
                     /protein_start="90"
                     /score="54.4"
                     /tool="antismash"
                     /translation="VLLSNPGGPGGQGIDTPLDMRKNLPKAVRQKYDLIGMDPRGVGRS
                     SPVSCGMKPEDENWLRPYKEEAFAKDVAWARDVADKCRAKAGDRLPHITTRNTARDMDL
                     LRAILGETKISFLGYSYGTYLGAVYTQLFPGRADRFVLDSAVDPKRAWRGMIQWWAEGA
                     "
     misc_feature    3742..3755
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.14"
                     /tool="antismash"
     gene            complement(<3828..>3971)
                     /locus_tag="EES43_RS31200"
                     /pseudo=""
     CDS             complement(<3828..3971)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946701.1"
                     /locus_tag="EES43_RS31200"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRSRGGLTTRIHLPVDASFHVLAAVITAGQRGDAPVFGQVMDGIR
                     VPR"
     gene            complement(4034..>4918)
                     /locus_tag="EES43_RS08195"
                     /old_locus_tag="EES43_08145"
     CDS             complement(4034..>4918)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117171.1"
                     /locus_tag="EES43_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08145"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_164493127.1"
                     /transl_table=11
                     /translation="APAPASASASDSAPASTSTGPTPPGRVPRSSDLSLVDVEYAYGPG
                     AVPVISGLSLHIPAGSHLAVVGPSGTGKSTLTALLSGLYRPDSGRLTLGGVPAADADRS
                     WIHRAVAMIPQEAYVFTGTVRDNLRYLRAEATDAELLASSVAVGAQDLVERLGGLHAAV
                     GLDGPELSSGERQLIALARAHVSAASIVLLDEACCHLDPAAEERAENAFAARGTTLIVV
                     AHRISSALRAPRVLVLDGERTAAGTHDELLGESPLYRELVGYWTADRPDDPGRPAPLSA
                     PGARTPEPGPPAR"
     assembly_gap    4919..5090
                     /estimated_length=172
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<5091..6083)
                     /locus_tag="EES43_RS08200"
     CDS             complement(<5091..6083)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="EES43_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_164493128.1"
                     /transl_table=11
                     /translation="MSAPPEAPAPIDRRMLAGFLRRHRRAAVAVTGWSVLEAVPALSSG
                     LLVAAALDRGFLAGRPGAGFFWIGLLGAAMVLRALMTRALTPWLGRLVEPLRDELVTAV
                     ASGALHRAAGGARGPAGAGVARLTVQVETVRSLVSALLRSARQLGVSLLMAFVGLAALS
                     APAAAVTLPPVVLTLLLCVPRLRTLARRQRGQLRAEERLTALAGEVFDGIRDVVACGAR
                     DRVAAELGVRIIEHRDACRGVARTASANTLLVSFGSHLPLLALIVAAPALLRGGTLSVG
                     ELLGATSYLLSGVAPALRSLVAVLGSWGVQLTTVLGRLARSSAPASAPAS"
     gene            complement(6080..7810)
                     /locus_tag="EES43_RS08205"
                     /old_locus_tag="EES43_08155"
     CDS             complement(6080..7810)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="EES43_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08155"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_124268115.1"
                     /transl_table=11
                     /translation="MTSPQGLLRDATAEARGWFLLTVATAVIGSAGTLALPWAMARALD
                     AVVAGQPASVPLAAFACLLAVVVTAGALQTLANGGYGSATVAALRRTLARRALDAGVPG
                     AARFPAGDLAGRLSAGCAQAGSAGVTVVTTAASLLTSLGGVVALWLLDWRLGLCFSLGV
                     PPLVLIARLFMNRSSGLFLHYQQTQGRISALLLEALGGARTIGASGTARAEAARVLQPL
                     PELSRTGHRIWRLQRDTGWQVGLLAPVVEVLVLGVGGLALLNGDISAGELAAVVAYAAV
                     AMSALDQLDALFALGVSVAGARRVAEVVDQPAATPGTRGRVAGRRGRVTLSGVTVRSGP
                     RLVLDAVDLDVPAGTTLAVVGRSGAGKSNLAALIGRLREPDGGTVAVDGVPLRELAPHA
                     LHAAVGYAFERPALLGGTVRGMIAFARPDVSDEAVRAAAAAARADDFVRRLPHGFDTPL
                     HDAPLSGGEIQRLGLARALVHDPDVIVLDDATSSLDTATEARVDSALASAWSDRTQVVI
                     AHRASTAARADLVLWLDDGRVRALGTHRALWRRTAYRELFAAAPAAPAPRRSATRQETA
                     "
     gene            complement(7911..8027)
                     /locus_tag="EES43_RS30965"
                     /old_locus_tag="EES43_08160"
     CDS             complement(7911..8027)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038157.1"
                     /locus_tag="EES43_RS30965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08160"
                     /product="ALQxL family class IV lanthipeptide"
                     /protein_id="WP_206430007.1"
                     /transl_table=11
                     /translation="MTVDVDELQTLEGEESVALAGCTATCAWTCAITSIEQQ"
     CDS_motif       complement(7965..8027)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTVDVDELQTLEGEESVALAG"
                     /locus_tag="EES43_RS30965_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7911..7964)
                     /prepeptide="core"
                     /locus_tag="EES43_RS30965_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.70"
                     /molecular_weight="1740.0"
                     /monoisotopic_mass="1738.8"
                     /core_sequence="CTATCAWTCAITSIEQQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVDVDELQTLEGEESVALAG"
                     /leader_location="[7964:8027](-)"
                     /alternative_weights="1758.0"
                     /alternative_weights="1776.0"
     gene            complement(8109..9938)
                     /locus_tag="EES43_RS08210"
                     /old_locus_tag="EES43_08165"
     CDS             complement(8109..9938)
                     /NRPS_PKS="Domain: Abhydrolase_1 (373-484). E-value:
                     2.5e-09. Score: 29.1. Matches aSDomain:
                     nrpspksdomains_EES43_RS08210_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="EES43_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08165"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_241192627.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-06, bitscore: 26.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.6e-20, bitscore:
                     71.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAADGGLVPGWWDLDGTGPRYREGSSAESTATQVLPTEDGGLLR
                     LRGAAGSGRHLLMLSHPTETADLTETADPAGTDGAEDAGERTAVEARGLRLVAGGPQDV
                     LALAVETDPHGRTRVWQVRPAPLRLTDPVALPGRVGGLLPLDATGRRYATDLAPDGRYR
                     PGLGRTDDCRPVVLDLRDRTWHPLASPAGGRVHRLLLSLPGSGALLAAADAGDGRLRIA
                     RTSLDGTARLDFPEGLNSLDGAVFPLAADPSGERVALRVSRGAQARLFLYDLADDLPRP
                     AELAPGALHSAAGWSEGGLRVVYATPDRPADIVTVPGTVAYGRERPAHPAAGWKDPAPT
                     YASTATSASTEWFPTPSGTFEAVCLGDWRTASTVVVALHGGPEGRWTLDYDPVFASLSQ
                     GGIAVVAPNQRGSTGYGRPHAAAVHGAWGVPDLADIRSLVRTLTEHRPPGFEPPAVLGV
                     SYGGFLALLAVCADPDAWSRCAVIAPFLSARGLHERATPAVRALIDRHGLGEPPDDDLG
                     PRDVERLAHRVRVPLLAVHGADDPLVPVDETRRLRRRLAEAGRTEHVHFDCLEITGAGH
                     HPLQERGGAELTDRLVTFLAAGLPARRTAAAHP"
     aSDomain        complement(8487..8819)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EES43_RS08210_Abhydrolase_1.1"
                     /evalue="2.50E-09"
                     /label="EES43_RS08210_Abhydrolase_1.1"
                     /locus_tag="EES43_RS08210"
                     /protein_end="484"
                     /protein_start="373"
                     /score="29.1"
                     /tool="antismash"
                     /translation="VVVALHGGPEGRWTLDYDPVFASLSQGGIAVVAPNQRGSTGYGRP
                     HAAAVHGAWGVPDLADIRSLVRTLTEHRPPGFEPPAVLGVSYGGFLALLAVCADPDAWS
                     RCAVIAP"
     gene            complement(10001..12976)
                     /gene="lanL"
                     /locus_tag="EES43_RS08215"
                     /old_locus_tag="EES43_08170"
     CDS             complement(10001..12976)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="EES43_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08170"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_124268117.1"
                     /sec_met_domain="Pkinase (E-value: 4.5e-15, bitscore: 54.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.7e-41, bitscore:
                     140.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADRAAHGTSRYFAVDTGLLPGIVDGVLRRRGAAEWAVEQGDFW
                     CSVRPAGHESGEQGWKLHLSATPLSAALVLAVAADVLVEERASFKFAGALDRVALLTGG
                     RADRGGGGKFVTVYPDDPDHFRRLARRLHRATTGLRGPRILSDRPYAADSLVHYRYGVF
                     RGVRVTTNDGESDVRLRRPDGVLEKDRRKAWVTTPPWAPEPFPDEPGRDDTLAAPPAPP
                     ASAGASDSGTAGTAASAPARRKAVRLNDRYVVRKAIRHAFKGGVYLATDELTGRQVVVK
                     EARAHVGVRVDGSDLQDTLRHESEMLGRLAPLGFTPAAIDLFAQGGNLFLVQEHVPGRT
                     LRDRLAERPVGGLEEFLSLARQVVDVVDAVHGTGHVLRDLSPNNLMVTPDGRVRLIDVE
                     YLVPDGVPVRRGYTPGYVGPEVSSLTDFDVTAPTRAGDLYSLGAVLLHLAVGVDMLLVP
                     DDRPVGDRTEALIALAVADRAWTKPLLPVLLALCSSRPERRWDLSRVREALADVEREKA
                     VAAPAGSGYAAEPGRPAGAGTVADSGITDEDGERLIADGLAHLLRTRREGGGHLWELSG
                     FGATTDPLNAQYGAAGVLAVVTRAAAARGGVELHRGVAELAEWTRRRLTDPSAGRTADG
                     TVLPGLYFGRSGTAWALLDAARLLGDDDGVEEACALARAVPVDWPNRDVCHGAAGAGMA
                     QLHFWHTTGDPVFRDRAAACAEAVLAAAEDHPAGVIWPIPATFDSSLAGARHYGFAHGI
                     AGIGAFLLAAGLAAEREDFVSAARTAGDTLVALARVEDGRAAWPAGDRAADGPVGQTHW
                     CSGSSGIGAFLIRLWRTSGDVRHRDLAALAAVAVRQAMWASSPAACHGLSGNAEFLLDM
                     SAVLKDSRYRDRARELAACIATRAVLRDGLLVVPDESLEAVTAGYQTGLSGTVGMLLRL
                     RYGGSRLWMPDPPDLHAAAAGRDAVEDRRTPAGRSIPAGRSIPAGRSIPAGPDARVVAG
                     TA"
     misc_feature    13153..13167
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            13405..14490
                     /locus_tag="EES43_RS08220"
                     /old_locus_tag="EES43_08175"
     CDS             13405..14490
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EES43_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EES43_08175"
                     /product="hypothetical protein"
                     /protein_id="WP_124268118.1"
                     /transl_table=11
                     /translation="MVLATALYRGSHLVAGVVNVSQHQRDRPIQWLLLGTAIASTALVC
                     TAARRRGRVTRRAVGLDALVVGCLLPFGAYAWGGAREPETIAWTMLLGGSASALAAVAF
                     GVRGTAIAVALLVSTHLVGYLLVHADAAVTATHLNALVFSAVVARVLAWYLCRQGARLD
                     AANHRALTAEAQRARYAERITHYSALHDTVLATLTAIARGGVDANTAVMRQRCAREAAY
                     LRRLVEHTDGETPDSDIRAALEESVRAAEALGLRVTARYHEPPAVPGDIALIVAQAATE
                     ALNNVRCHAGTDHAYLTATGDAGRLVVTVVDRGRGFDAGDLTGGLGLDRSVHTRMRAIG
                     GLASVDAAPGEGVRVELRWPS"
     cand_cluster    13760..24053
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    13760..24053
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[18759:19053](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(18760..19053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            14478..15128
                     /locus_tag="EES43_RS08225"
                     /old_locus_tag="EES43_08180"
     CDS             14478..15128
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061151.1"
                     /locus_tag="EES43_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08180"
                     /product="response regulator transcription factor"
                     /protein_id="WP_124268119.1"
                     /transl_table=11
                     /translation="MAQLITVAVVDDDRMLLDGIRSWFDGAAGLRLVACARTVDELLAE
                     RREPPDVVLLDLMLRDGRPPAENIRRLRESGSRVLMISVVPDRDRIVAAVADGADGFIT
                     KDHDLSVLVEAVREVAAGRTAHSPELAFALAYDRGARPRLSPKEREVLVGYASGLTLKA
                     TARRAGITVNTAKYYVDRVKTKYQEAGRPTYTKIDLATRVREDGWVHPGTPTA"
     gene            complement(15799..16455)
                     /locus_tag="EES43_RS08230"
                     /old_locus_tag="EES43_08185"
     CDS             complement(15799..16455)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374867.1"
                     /locus_tag="EES43_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08185"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_124268120.1"
                     /transl_table=11
                     /translation="MIDIKNLSKSFGARTVWSDISFTVNGGEMLALIGPSGSGKSTLLN
                     CLGLLERPDKGEICYEGKDITRFGRRDIRRYRRDTLGYLFQHYALIETATVHENLEVVT
                     KLRRSSQRPDNTSLAEVLDRVGLTGREEEKISHLSGGEQQRVALARLMIQQPTVVLADE
                     PTGALDDANSTMVIDILEGMSKSGCSVVIATHDDSVRSRCDAVFAVHDSSLVGSL"
     gene            complement(16496..18553)
                     /locus_tag="EES43_RS08235"
                     /old_locus_tag="EES43_08190"
     CDS             complement(16496..18553)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EES43_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EES43_08190"
                     /product="hypothetical protein"
                     /protein_id="WP_124268121.1"
                     /transl_table=11
                     /translation="MAFSVVLSFLFLRGLDESTVLGNSALVTVLDSDDSVSAAQAVRLV
                     ESFATEHGVAVGREVPDLKNPDGRRHLYLATGDAGTVTASWLSKGYPAFSEKYDTRVHP
                     LSEIGHQDPRGSYYVFGSSEAADALVSDFSDRGMVASVIHPLSYEELSKTYTDDPLFRA
                     LGVVALAALTMTGASVLLNVKTYAVLRMQGMSFTGILLHDLRQLRVSWLMAAGVVATTT
                     LGFLGLYNGFAWLGLFTSVAVVIAVLLSALVLATHAAVLALTCKVDVLPALKGELPSRA
                     ASISVYLVRIPALLLALSIAGHVSFAARDVLTRQENREVYDTVGDAVSIRLNGAFAMQL
                     DELDKHVGPWLRQADQRGEVIVSGRRDLQLSVPEAHLPAGEILIVNDTYLGEQSVIGIN
                     GRRYSATSGNGNSKSSQVRVIVPESLTSHTPDIAQAASRIIDPHLSRNIPLETLTSKTG
                     QRVFGYNTGTNVYSAAHSADEDRSLVDDPVLIVVPNGSFLTNDAYATFATQGGVVFPDP
                     NDALNGIRSQSLRNYVSSVSPVGQKAALDLREASNKFRLHTFNLIIAMIVLLVAGAGVC
                     IIYSRKNAQNIFVRHISGWRYSATHRFILAVEVAIAIIFASRVPFENWQQNRELRDLAA
                     AGAPAPFEAVHITALDTSVITGLVVFELAAVLLALAFFHRRIIKEGATEG"
     misc_feature    18632..18650
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(18648..18657)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            complement(18760..19053)
                     /locus_tag="EES43_RS08240"
                     /old_locus_tag="EES43_08195"
     CDS             complement(18760..19053)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF021219.4"
                     /locus_tag="EES43_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08195"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_164493129.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 6.8e-11,
                     bitscore: 41.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRTGAKAAIATVGLVLAAATPALATTVNVGGGTWSYDQGANTA
                     WSNYKHASNYHASSVSIGGQLSRSGCTSPGSWSLASGSKNGGSINYYYDPSC"
     misc_feature    complement(19079..19092)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(19147..19163)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    19147..19163
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.5"
                     /tool="antismash"
     misc_feature    19152..19165
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.96"
                     /tool="antismash"
     misc_feature    complement(19154..19172)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.56"
                     /tool="antismash"
     misc_feature    complement(19155..19168)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.96"
                     /tool="antismash"
     misc_feature    19156..19169
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.82"
                     /tool="antismash"
     misc_feature    19222..19236
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.4"
                     /tool="antismash"
     misc_feature    19229..19243
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.69"
                     /tool="antismash"
     gene            complement(19300..19461)
                     /locus_tag="EES43_RS30535"
     CDS             complement(19300..19461)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EES43_RS30535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164493130.1"
                     /transl_table=11
                     /translation="MSEGFCGGGASQSDGRMMQLVPAMRGPMKSSALQDAIAVATDSFF
                     LAGIMPYG"
     gene            19570..20970
                     /locus_tag="EES43_RS08245"
                     /old_locus_tag="EES43_08200"
     CDS             19570..20970
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010469705.1"
                     /locus_tag="EES43_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08200"
                     /product="glycosyltransferase family 39 protein"
                     /protein_id="WP_164493131.1"
                     /transl_table=11
                     /translation="MVWTLALGLWGLSRQDSVWRDEAATWQVAQRSTAEIWSMLGNVDV
                     VHGCYYLFMHGLFEYFGPSTTTLRLPSVLATAVAAACVAAIGHRLAGLSVGLAGGLAFG
                     LLPAVQFYLQEGRPYALVAAGAGISTLLLVTALQGRTQMPHWFAYGGTVLACGLLNWLS
                     LMILPAHLLTLLWTRPTLRISVRWAAASAAATACVLPLMLFSHSQSVQVSWIPPLTWHM
                     LIGPTVLLLIGGIGAALDRPRAGDLSVAAVGLPLLAVPQLGLAGLSLIQPLFLDRYILF
                     SLLGLALLIGSIIGSAVQAAAPRFPRASRWILPAVVALAVMALLPQALAKRSPASRVDD
                     VLAAASEVRLMNEPGSAVLFIPSARRDTKSVSPSAFAGLRDIALAQSPEESGTLKGVEA
                     DPDQIRAAMLAQHRIVLVTDASQVAKPVTAKRDKLKTSVLTTYFTVVADEQVRGRRVTA
                     YERRAATH"
     gene            21949..22119
                     /locus_tag="EES43_RS30540"
                     /old_locus_tag="EES43_08205"
     CDS             21949..22119
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EES43_RS30540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EES43_08205"
                     /product="hypothetical protein"
                     /protein_id="WP_164493132.1"
                     /transl_table=11
                     /translation="MPQFTAAPDAQNNGKFDLWATTHNSGRLRIFADYTTAGHTAVLIA
                     SKELADYQAIS"
     tRNA            complement(22479..22555)
                     /anticodon=(pos:complement(1880339..1880341),aa:Ile,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EES43_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EES43_08210"
                     /product="tRNA-Ile"
     gene            complement(22479..22555)
                     /locus_tag="EES43_RS08250"
                     /old_locus_tag="EES43_08210"
     tRNA            complement(22777..22849)
                     /anticodon=(pos:complement(1880634..1880636),aa:Asn,
                     seq:gtt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EES43_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EES43_08215"
                     /product="tRNA-Asn"
     gene            complement(22777..22849)
                     /locus_tag="EES43_RS08255"
                     /old_locus_tag="EES43_08215"
     misc_feature    22822..22836
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.25"
                     /tool="antismash"
     tRNA            complement(22855..22927)
                     /anticodon=(pos:complement(1880712..1880714),aa:Asn,
                     seq:gtt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EES43_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EES43_08220"
                     /product="tRNA-Asn"
     gene            complement(22855..22927)
                     /locus_tag="EES43_RS08260"
                     /old_locus_tag="EES43_08220"
     gene            23111..23413
                     /locus_tag="EES43_RS08265"
                     /old_locus_tag="EES43_08225"
     CDS             23111..23413
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969335.1"
                     /locus_tag="EES43_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_08225"
                     /product="YtxH domain-containing protein"
                     /protein_id="WP_124271847.1"
                     /transl_table=11
                     /translation="MRYRLTFIAGVALGYVLGTRAGRERYEQLKKSARQFAGNPAVRNA
                     AETAAHSGRDIAGKAYHSVSDKVGDRVPASVADRVRSLRDRSSQNGEDDWGTTNT"
ORIGIN
        1 tcgatcgtcg gctgaggcgt cagggcgacg ggtcgcgggc gtcgtggcgg ccgaggcgtc
       61 agggctgcgg gtcgcgggcg tcgtagcggg cgaagccgcg ccacttcagc gccagcaggc
      121 agaccacggc cacgcaggcg aggccgccgc cggtgaccgc cacggcgggc gagacgaggt
      181 cggcgaccga accggccacg aagtcgccga gccggggccc gcccgcgacg acgacgatga
      241 acacgccttg cagccggccc cgcatctcgt cgggcacggc cgcctggagc atggtgttgc
      301 ggaagaccat ggagacggtg tccgcgcagc cggcgagcgc caggaacagc agtccgagcc
      361 agagctgccg ggtgagcccg aagacggcga tggcgctgcc ccagcagccg acggccagca
      421 ggaccgcgag gccgtgccgc cggatccgcc cgagccagcc ggagaacacg ccgcccagga
      481 gcgcgccgag cgccggggcg gcgacgagca gtccggtggt gcgggcgtcg ccgccgtacc
      541 agaggacggc gaccaccggg aagagcgccc gggggtgggc cagcaccatg gcggccaggt
      601 cggtgaagaa ggtcatccgc aggttgggcc gggtaccgag gaaccgcagc ccgtccagca
      661 cggaggcccg cttgcgcttc ccgcccggat cccgctcctc gccccggtcg ggcagcatcg
      721 agggcagccg ccacatcgcg tagagggagg cggtgaaggt gacggcgtcg acggtgtagg
      781 cggcgcggta gccccaccag ccgacgatca gcccgccgag catcggcccg accagcgcac
      841 cggtcgtact ggtcatggag ttcagcgcgt tggcggcggg caactgctcg gcgggcagca
      901 gccgggcgat catcgaggag cgggccggcg cgttgagcgc gaagcagacg gcctggaggg
      961 cgacgacggc gtacagcagg ccgacctgct cgatcccggc gacggtggcg gcgaccagca
     1021 cgacggagag gacgaacgac ccggaggcgc tgaacagccc cagcctgcgc cggtcgacgg
     1081 tgtcggcgac cgctcccccg tagagcccga acacgacgag cggcacgagc gagcagaacc
     1141 cgatgagccc gacggagaac gcggatccgg tgatgtcgta gacctggagc gagacggcca
     1201 gcgccgtcat gccctgaccg acccaggaga cggtgttccc gaaccacaga cgccggtagt
     1261 cgggcgaggc ccgcagcggc gtgaggtcgg cgaatatgcg ggcgcggcgg gcgggaggcg
     1321 gctcggtcgt ttcggtcaca gaggatggta gccacctccg ccgggacctt ctccggcgtt
     1381 tccgcaaggc cactgtccct gtgcggggtc atcgggccgg cggcggcgcg ggcacgggcg
     1441 cgtggatgcc ggggcccggg ggcctgggga ggcccggggc ccgggggcct ggggccgtta
     1501 cggacgccgt gtcgtccgct cgacgtatcg cgcgagatcc tgcgtgcaga aggccgatgc
     1561 cgcgcagcgc cgtgacggta gcgtcgatcc accggcagcg cttcgaagaa ggccgccacc
     1621 gaggggtgga ggtcgggctg ctcgtcgcca ccgatgttcg tgcggctgta gatcttcccc
     1681 tggacgagca aggaagcggc cacaccggcg tacgcgggag cggcggtgat gagcggggtc
     1741 agggctaggg tgagcgcggc gaggccgccg gcaaaattct gagcgtcgga cgcagcaccc
     1801 gggcccctgc ggaggagtgt ccgcaggggc ccgggtgctg cgtcggggcg gcccggctca
     1861 gaaccggtcc ggagcgcgat ccgggagcgg tgagcccggc agcgcatccc gcttccggtc
     1921 cttccgcgcc tcctcgttcg acttgggcgt cgcccggcag atcacgtcct tcgccgggag
     1981 cttgccggtg agcaggtact cgttgaccgc gccgtccgtg cacacgttgc cgttcggata
     2041 gacgccgtgg ccctcaccgc cgcgcacggt gaccatcttc gagcccctca gggcagcgtg
     2101 cagggcctga ccgctgggca gcggggtctg cgagtcccac tcgttctgga cgaccaggga
     2161 accgaccctg ttgttcacct tggtcaccgg ttccgcagac ctgtcccaga aggcacaagg
     2221 cttgatgctg gacgccatgt caccgaagag cgggtagcgc tttttgtccg cgatggcgtc
     2281 ctgccggtag cgctcgggat cgcgggacca ggccgccgag ttgtcgccgc acaccacggc
     2341 gaagaagctc gctctcgcgt tgtcggacgg cacttcggcg ccccctgggc gcccgcttcc
     2401 cgccgatccg gcgaacgccg cgaacttcct cgcggaagtg ggccggccgg cggcggccct
     2461 cttcagcagc acgacctcat cggtggccca ctccggggtg aagaccaggc tgcgcaatcc
     2521 gctgcggatg tcatcaccgg tggtcagctg tccacccacg tcgatgggct tctcatccgc
     2581 ctgcgcgacc aacttccata gagtgcgctc gacttgcttc ggggtcgcgc caagtttgta
     2641 cgtctccgag cgctcggcgg cccactcggt ccaccggtcg aacgccggct cggcgccttc
     2701 ggcccaccac tggatcatgc cgcgccaggc acgcttcgga tcgaccgcgc tgtccagcac
     2761 gaaccggtcg gctcggccag gaaagagctg ggtgtagaca gcgcccaggt aggtgccgta
     2821 cgagtaaccc aggaacgaga tcttcgtctc accgaggatc gcccggagca ggtccatgtc
     2881 ccgtgcggtg ttgcgcgtgg tgatgtgcgg gagtctgtcg cccgccttcg ccctgcactt
     2941 gtccgcgaca tcgcgtgccc aggcgacgtc cttcgcgaac gcctcctcct tgtacgggcg
     3001 cagccagttt tcgtcctcgg gcttcatacc gcaggaaacc gggctgctcc gtcccacacc
     3061 tcgcgggtcc atgccgatga ggtcgtactt ttgccggaca gccttgggca ggttcttccg
     3121 catgtccagc ggcgtgtcga ttccctggcc gccgggcccg ccggggttgg acaacaggac
     3181 gccgtgccgc ttgcccggtg cggtgctctt gatccgggat atggccaggt cgatccgctt
     3241 ccctccggga acgcggtagt ccagcgggac cttgatcgtg gcgcactgca acaccgccgg
     3301 agtatcggct tcacagcgtt tccatcgggg cttctgcttc acataccgct ccagcgcgtt
     3361 cctggcaggc ggggaagagg cggtcggcgg cccggcggcc gggacggcac cggccggcgg
     3421 ggccgagagt acgggaacca ggggcgccat ggcactcacg actaacagag gtatgagacg
     3481 tcgtctgcgc acgctgtcga tccttccggt cgcatggggt gagacaggaa ggatcattca
     3541 ggagagggcg gcgcgtgcgg atcccccacc gggccgcatt tcctctccgc cttcagaagg
     3601 acacgacggt cgtgggtggt acccgagttg taggagagac ggcagctacc ggggctcgac
     3661 gtccgagatc gccgctgtcg aacaggccgg gagctggtgt ggcttcacgt catgcggcag
     3721 atccagggcg ggcgggaact ggggatggcc atgcaccaac ggtttcggga taccggctgc
     3781 acggaaagtg gctcggcttc ggggcggacc acccggtggc cgccgatccg ggggacacgg
     3841 attccgtcca tcacctgccc gaagacgggt gcgtcgcctc gctggccggc ggtgatgacg
     3901 gccgcgagga cgtggaagga ggcgtcgaca gggaggtgaa tcctggtggt cagcccaccg
     3961 cgcgagcgcc ccgggccgtg gccgtcccac tcgagcgagc agaacccggc aaggcccccg
     4021 tccctgtgcg gggtcatcgg gccggcggtc cgggctccgg cgttctcgca ccgggtgcgg
     4081 agagcggagc cggccggccc gggtcgtccg gtcggtcggc cgtccagtac ccgaccagtt
     4141 cgcggtagag cgggctttcc ccgagcagtt cgtcgtgtgt gccggcggcg gtccgttcgc
     4201 cgtcaagcac caggacacgc ggggcgcgca gcgccgagct gatgcggtgc gcgacgacga
     4261 tgagggtggt gccgcgggcg gcgaacgcgt tctcggcgcg ctcctcggcc gccgggtcga
     4321 gatggcagca cgcctcgtcc agcagcacga tcgacgcggc cgagacgtgg gcccgcgcca
     4381 gggcgatgag ctgccgctca ccggaggaga gttccggtcc gtccagtccc accgccgcgt
     4441 gcaggccgcc cagccgctcg acgaggtcct gggcgcccac ggccaccgag gacgcgagca
     4501 gttcggcgtc cgtggcctcc gctcgcaggt agcgcaggtt gtcccgcacc gtgcccgtga
     4561 agacgtacgc ctcctgcggg atcatcgcca cggcgcggtg gatccaggag cggtcggcgt
     4621 ccgcagccgg gacccctccc agggtcaacc ggccgctgtc cggccggtac agcccggaca
     4681 gcagtgcggt cagggtcgac ttccccgtac cgctcgggcc gacgaccgcc aggtgcgatc
     4741 cggcggggat gtgcagggag agcccgctga tcaccggtac ggccccagga ccgtacgcgt
     4801 actcgacgtc caccagggac aggtcggacg aacgcggtac gcggcccggc ggcgtcggcc
     4861 cggtggaggt ggaggcaggg gcggagtcgg aggcggaggc ggaggcgggg gcgggggcnn
     4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ggaggcgggg
     5101 gcggaggcgg gggcggagga ccgggccaac cggcccagca cggtggtcag ctgaactccc
     5161 caggacccca gcacggcgac gagcgaacgc agggcgggcg cgacgccgct gagcaggtag
     5221 ctggtggctc ccaggagttc gcccaccgac agtgtgccgc cgcgcaggag ggcgggggcc
     5281 gccacgatga gggcgagcag gggcagatgg ctgccgaacg acaccaggag ggtgttggcc
     5341 gaggcggtcc gggcgacgcc gcggcacgcg tcccggtgct cgatgatccg tacgccgagt
     5401 tcggccgcca cccggtcgcg ggcaccgcag gcaacgacgt cccggatgcc gtcgaacacc
     5461 tcgccggcga gggccgtcag gcgctcctcg gcccgcagtt gtccgcgctg tcgccgggcg
     5521 agtgtgcgca ggcgcggaac gcagagcagg agggtgagga cgaccggcgg cagggtgacg
     5581 gccgccgccg gcgcggacag ggcggccagg ccgacgaagg ccatcagcag cgagacgccc
     5641 agttgccggg cggagcgcag aagcgccgag accagtgaac gcacggtctc cacctgcacg
     5701 gtcagccgcg ccactcccgc accagcgggt ccccgggcgc cgccggcggc ccggtgcagc
     5761 gcgccggatg ccaccgccgt gaccaactcg tcccggagcg gctccacgag ccgccccagc
     5821 cacggggtga gcgcgcgcgt catcagggcg cgcagcacca tcgcggcccc gagcagcccg
     5881 atccagaaga accccgcgcc gggccgcccc gcgaggaagc cccggtcgag ggcggcggcg
     5941 accagcagac cggagctgag cgccggaacc gcctccagga ccgaccaccc cgtgaccgcg
     6001 accgccgcgc ggcggtgccg gcggaggaac ccggcgagca tgcgccggtc gatgggggcg
     6061 ggggcctcgg gcggggcgct catgccgtct cctgccgcgt cgcggaccgc cgcggggcgg
     6121 gggcggcggg cgcggcggcg aacagctcgc ggtaggccgt ccgccgccac agcgcgcggt
     6181 gtgtccccag ggccctgacg cgtccgtcgt cgagccagag caccaggtcg gcgcgggcgg
     6241 cggtggacgc ccggtgggcg atcaccacct gggtccggtc ggaccaggcc gaggcgaggg
     6301 cggagtcgac ccgcgcctcg gtggcggtgt ccaggctcga cgtcgcgtcg tccaggacga
     6361 tcacgtccgg atcgtggacc aaggcgcgtg ccaggcccag tcgttggatc tctccgccgg
     6421 agagcggcgc atcgtggagc ggcgtgtcga agccgtgggg cagccgtcgg acgaagtcgt
     6481 cggcgcgagc cgccgcggcg gctgccctca cggcctcgtc ggagacgtcc gggcgggcga
     6541 aggcgatcat gccgcgtacc gtcccgccga gcagcgccgg ccgttcgaag gcgtagccga
     6601 ccgcggcgtg cagggcgtgc ggggccagtt cccgcagcgg tacgccgtcg acggcgacgg
     6661 ttccgccgtc cggttcccgc agccgcccga tcagcgcggc caggttgctc ttgcccgcac
     6721 cggacctgcc gaccaccgcg agggtcgtac ccgccggcac gtcgaggtcg accgcgtcga
     6781 gcacgaggcg ggggccggag cggacggtca ccccggacag agtcaccctg ccgcggcggc
     6841 ccgcgacgcg gccccgcgtg ccgggcgtcg cggcgggctg gtcgaccact tcggcgaccc
     6901 ggcgcgcgcc ggcgaccgag acgccgaggg cgaagagggc gtcgagctgg tcgagggcgg
     6961 acatcgccac ggcggcgtac gccaccaccg cggcgagctc ccccgcgctg atgtcgccgt
     7021 tcagcagggc gagacctccg acgccgagca ccagcacctc cacgaccggg gccagcaggc
     7081 cgacctgcca gccggtgtcc cgttgcagtc gccagatgcg gtggccggtg cgggacagct
     7141 ccggcagggg ctggaggacg cgtgcggcct cggcccgcgc cgtgccgctc gcgccgatgg
     7201 tccgtgcgcc gccgagtgct tcgagcagca gggcggagat cctgccctgg gtctgctggt
     7261 agtggaggaa gagcccggaa ctgcggttca tgaacaggcg ggcgatgagt accaggggcg
     7321 gcacccccag ggagaagcag aggccgagcc gccagtcgag cagccacagc gcgaccactc
     7381 cgccgaggga tgtcagcagc gaggccgcgg tcgtgacgac ggtgaccccg gccgagcccg
     7441 cctgcgcgca gcccgcggat agacgcccgg cgagatcgcc cgccgggaac ctggccgcgc
     7501 ccgggacgcc cgcgtccagg gcgcgccggg ccagggtccg gcgcagcgcg gccaccgtcg
     7561 cggagccgta ccctccgttg gccagggtct ggagcgcccc cgcggtcacc acgacggcga
     7621 gcaggcaggc gaaggccgcc agggggacgg aggccggttg tcccgcgacg accgcgtcga
     7681 gggcccgtgc catggcccag ggcagggcga gggttccggc ggagccgatg acggccgtgg
     7741 cgacggtgag gaggaaccag ccgcgtgcct cggcggtcgc gtccctcagc aggccctgcg
     7801 gggacgtcat ggctctcctc ccgggaatcc ggccggtggg ccggcgcggc gtgcggtgcc
     7861 gaggtgtcgc gccgggcgtg ccgggatccg gcacgcccgg cgcacgggtg ctactgctgc
     7921 tcgatgctgg tgatggcgca ggtccaggcg caggtggcgg tacagccggc cagggccacg
     7981 gactcctcgc cctccagggt ctgcagctcg tcaacgtcga cggtcatggt gtcgtcctct
     8041 cgtcatgagt gatcgcgata caccgccggg tccggcggtg ccacacggcc gcgggagcga
     8101 ccgcgaggtc aggggtgggc ggcggcggtg cggcgggccg ggagtccggc cgccaggaac
     8161 gtcaccagtc ggtcggtgag ttcggcgccg ccccgttcct ggagcgggtg atggcccgct
     8221 ccggtgattt cgaggcagtc gaaatggacg tgttccgtgc ggccggcttc ggccagccgc
     8281 ctccgcagac gcctcgtctc gtccaccggc accagagggt catcggcgcc gtgcacggcg
     8341 agcagcggca cgcggacgcg gtgggcgagg cgttcgacgt cccgggggcc gaggtcgtcg
     8401 tccggaggtt cgcccagtcc gtgccggtcg atcagcgcac gtaccgcggg cgtcgcgcgt
     8461 tcgtggagcc cgcgcgcgga caggaagggt gcgatgacag cgcagcggga ccaggcgtcg
     8521 gggtcggcgc acacggccag cagggcgagg aatcccccgt agctgacgcc gagtacggcg
     8581 ggaggttcga agccgggcgg gcggtgttcc gtcagcgtgc ggaccagtga ccggatgtcc
     8641 gccaggtcgg gcacgcccca ggcgccgtgg acggccgcgg cgtgcgggcg gccgtatccc
     8701 gtgctcccgc gctggttggg cgccaccacc gcgataccgc cctgcgacag cgacgcgaac
     8761 accgggtcgt agtccagcgt ccagcggccc tccggtccgc cgtgcagggc gacgacgacg
     8821 gtgctcgcgg tgcgccagtc gccgaggcag accgcctcga acgttcctga cggcgtcggg
     8881 aaccactcgg tggaggccga ggtggcggtg gaggcgtagg tgggggccgg gtccttccac
     8941 cccgcggcgg ggtgggcggg ccgctcccgg ccgtatgcga cggtcccggg gacggtgacg
     9001 atgtcggcgg gccggtccgg ggtggcgtac acgacccgca gcccgccctc gctccacccg
     9061 gcggcggagt ggagcgcgcc cggggccagc tccgcgggtc ggggcaggtc gtccgccagg
     9121 tcgtacagga acaggcgggc ctgcgctccc cgggagaccc gcagcgccac gcgttcgccc
     9181 gacgggtcgg cggcgagcgg aaagaccgcg ccgtccaggg agttgagccc ttccggaaag
     9241 tccagccgtg ccgtgccgtc gaggctggtg cgggcgatcc gcagccgccc gtccccggcg
     9301 tcggccgctg ccagcagggc cccggagccc gggagcgaga ggagcagtcg gtggacgcgg
     9361 ccaccggcgg gggaagccag cggatgccag gtacggtcgc ggaggtccag gacgaccggg
     9421 cggcagtcgt cggtccggcc gagaccggga cggtagcggc cgtcgggggc gaggtcggtg
     9481 gcgtagcggc gacccgtcgc gtccagcggc aggagtccgc cgacccggcc gggcaacgcc
     9541 acgggatcgg tcaggcgcag gggagcgggg cggacctgcc acacccgggt gcggccgtgc
     9601 ggatcagtct ccacggccag cgcgagcacg tcctgcgggc cgccggccac cagccgcagg
     9661 cccctcgcct ccaccgccgt gcgctccccg gcgtcctccg cgccgtccgt tccggcgggg
     9721 tcggcggttt cggtgaggtc ggcggtttcg gtggggtggg acagcatcag caggtggcgt
     9781 ccgctgcccg ccgcgccgcg cagccgcagc agcccgccgt cctcggtcgg caggacctgg
     9841 gtggccgtgg actcggcgga ggagccctcc cggtaccggg gtcccgtgcc gtccaggtcc
     9901 caccatcccg ggaccagccc gccgtcggcg gcggtcacca agcaggccgc gtaacgggat
     9961 cgctccgaga agcggaagct gaggcgttcc ggtcgccgct tcacgccgta cccgccacga
    10021 cgcgggcgtc cggtccggcg gggatgctcc gcccggcggg gatgctccgc ccggcgggga
    10081 tgctccgccc ggcgggggtg cggcggtctt cgacggcgtc gcgtccggcg gcggcggcgt
    10141 ggagatccgg tgggtccggc atccacagtc gggaacctcc gtagcgcagg cgcagcagca
    10201 tcccgacggt tccggagaga ccggtctggt agccggcggt gaccgcctcc agggactcgt
    10261 ccggcaccac caggaggccg tcgcggagca cggcccgggt ggcgatgcac gcggccagtt
    10321 cgcgggcccg gtcccggtag cgggagtctt tgagcaccgc ggacatgtcc aggaggaact
    10381 cggcgttgcc ggagagcccg tggcaggcgg ccggggagga ggcccacatg gcctgcctga
    10441 ccgcgaccgc cgcgagggcg gcgaggtcgc ggtggcgtac gtcgcccgat gtccgccaca
    10501 gccggatcag gaaggcgccg atccccgagg aaccgctgca ccagtgggtc tgtcccacgg
    10561 gcccgtcggc ggcgcggtcg ccggccggcc aggccgcacg gccgtcctcg acgcgggcga
    10621 gggccaccag ggtgtcgccc gccgtgcggg ccgcgctgac gaagtcctcc cgctccgcgg
    10681 cgagtccggc ggccagcagg aaggctccga tgcccgcgat gccgtgcgcg aacccgtagt
    10741 ggcgggcccc cgcgaggctt gagtcgaagg tggccgggat cggccagatc accccggccg
    10801 ggtggtcctc ggccgccgcg aggacggcct cggcgcaggc cgccgcccgg tcgcggaaaa
    10861 cggggtctcc cgtcgtgtgc cagaagtgca gctgggccat gcccgccccg gcggcgccgt
    10921 ggcagacgtc ccggttgggc cagtcgacgg ggacggcgcg ggccagcgcg cacgcctcct
    10981 cgacaccgtc gtcgtcgccc agcaggcggg ccgcgtcgag cagcgcccag gccgtgcccg
    11041 agcggccgaa gtacagcccc ggcaggacgg ttccgtcggc tgtccgcccc gcggagggat
    11101 cggtcagccg tcgccgcgtc cactccgcga gttccgccac cccccggtgg agttcgacgc
    11161 cgccgcgggc cgcggcggcc cgggtgacga cggcgaggac gccggccgcg ccgtactgcg
    11221 cgttgagcgg gtcggtggtc gcgccgaaac cgctgagctc ccagaggtgc ccgccgccct
    11281 cgcggcgggt gcgcagcagg tgggcgaggc cgtcggcgat cagccgctcg ccgtcctcgt
    11341 cggtgatgcc ggagtccgcg acggtccccg ccccggcggg acgccccggt tcggccgcgt
    11401 acccggagcc cgcgggcgcc gccacggcct tctcccgttc cacgtccgcg agggcttccc
    11461 gcacccggga gaggtcccaa cgacgttcgg gccgggagga gcagagggcg aggagtacgg
    11521 gcagcagcgg cttcgtccag gcccggtcgg ccacggcgag ggcgatcagc gcctccgtgc
    11581 ggtcgccgac cggacggtcg tcgggaacca ggagcatgtc gacgcccacc gccaggtgca
    11641 gcagcaccgc gccgagactg tagaggtccc ccgcgcgggt gggggccgtg acgtcgaagt
    11701 cggtcagcga ggagacctcg ggcccgacgt atcccggggt gtacccgcgt cggaccggga
    11761 cgccgtcggg gaccaggtac tcgacgtcga tcaggcgcac ccggccgtcc ggggtgacca
    11821 tgaggttgtt cggggagagg tcccgcagca catggccggt gccgtggacg gcgtcgacca
    11881 cgtccaccac ctgccgggcc agggacagga actcctccag gccccctacc ggccgctcgg
    11941 cgagccggtc gcgcagcgtc cgccccggta cgtgctcctg gacgaggaac aggttgccgc
    12001 cctgcgcgaa caggtcgatc gcggccgggg tgaagcccag cggcgccagc ctgcccagca
    12061 tctcggactc gtggcgcagg gtgtcctgga gatcgctgcc gtccacgcgc accccgacat
    12121 gggcgcgggc ctccttcacg acgacctgcc ggcccgtcag ttcgtccgtc gcgaggtaga
    12181 cgccgccctt gaaggcgtgc cggatcgcct tgcggaccac gtagcggtcg ttgaggcgga
    12241 ccgccttccg cctcgccggg gccgacgccg ccgtacccgc ggtcccggag tccgaggccc
    12301 cggccgacgc gggcggtgcg ggcggtgcgg cgagcgtgtc gtcacggccc ggctcgtcgg
    12361 ggaacggctc gggcgcccac ggcggagtgg tcacccacgc cttgcgcctg tccttctcca
    12421 acaccccgtc gggcctgcgc agccggacgt ccgactcccc gtcgttcgtc gtcacgcgca
    12481 caccgcggaa caccccgtag cggtagtgca cgagactgtc cgcggcgtag ggccggtcgg
    12541 acaggatgcg cgggccccgc agccccgtcg tcgcgcggtg cagtcgtcgg gccagtcgcc
    12601 ggaagtggtc gggatcgtcc gggtacaccg tgacgaactt gccgccgccg ccccggtccg
    12661 cccggccgcc cgtcagcagc gcgacgcggt ccagcgcacc ggcgaacttg aaggaggccc
    12721 gctcctcgac caggacatca gccgccaccg ccaggaccag cgccgcggac agcggtgtgg
    12781 cggacaggtg gagcttccag ccctgctccc cgctctcgtg gccggccggg cgcaccgagc
    12841 accagaagtc cccctgctcg actgcccatt ccgcagcgcc ccgccggcgc agcacgccgt
    12901 cgacgatgcc gggaagcagg ccggtgtcca cggcgaagta cctgctggtg ccgtgtgcgg
    12961 cgcggtcagc ggtcacgggg caagatcctt ccggtgcgga gctcggagca gagaggtccc
    13021 acgaggggtg cgggagagcg tggccgtggc cggacaccgc tcccgggcgg tggccgtggc
    13081 cggacaccgt ccgggaggac ggaggcggcc gtgttcggca aggcgtttcg ggcgcaaaac
    13141 acctgatggc taatcacatg agtcgatgga acgccatagg ggaaccgggc atattcgatg
    13201 ggaaacacgc agagatgtcc gagaatctcg ggtcacccct cgaccagctg tgcctatcgt
    13261 ggccgcgagc gatcccttga tctccacggg tgacgttagc ggtgcgccga ggggccgggg
    13321 caccacccgt tctggggggt tgcgatcaag gggggccgac ggatccacaa caaggacagc
    13381 gggctcgacc gcgcccggaa ctcgatggtg ctggccaccg ctctctaccg gggcagccac
    13441 ctcgtcgcgg gcgtcgtcaa cgtctcccag caccagcgcg accgcccgat ccagtggctg
    13501 ctcctgggca cggccatcgc ctccacggcc ctcgtctgca ccgcggcgag gcggcgggga
    13561 cgggtcacgc gccgagccgt gggcctggac gccctggtcg tcggctgcct gctccccttc
    13621 ggcgcgtacg cgtggggcgg cgcccgggaa ccggagacga tcgcctggac catgctgctg
    13681 ggcggttcgg cctcggccct ggccgctgtg gccttcggag tgcggggaac cgcgatcgcc
    13741 gtcgccctcc tggtctcgac acacctcgtc ggctacctgc tcgtccatgc cgacgccgct
    13801 gtgaccgcga cccacctgaa cgccctggtg ttctcggccg tcgtagcccg ggtgctcgcg
    13861 tggtacctct gccgccaggg cgcgcggctc gacgccgcca accaccgggc gttgaccgcg
    13921 gaggcccagc gggcgaggta cgcggagcgc atcacccact acagcgctct gcacgacacg
    13981 gtcctcgcca ccctgaccgc catagcccgc ggcggtgtgg acgccaacac cgcggtgatg
    14041 cgccaacggt gcgcccgcga ggccgcctac ctgcggagac tggtcgagca cacggacggc
    14101 gaaacacccg actcggacat acgagcggca ctggaggagt ccgtccgggc cgccgaggca
    14161 ctcggcctgc gggtgaccgc ccgctaccac gagccgcccg ccgtccccgg cgacatcgcg
    14221 ctgatcgtcg cgcaggcggc gaccgaagcc ctgaacaacg tccgctgcca cgccgggacc
    14281 gatcacgcct acctgaccgc caccggggac gccggccgac tggtcgtcac cgtggtcgac
    14341 cggggccggg gcttcgacgc cggggacctc accggcggcc tcgggctcga ccggtccgtg
    14401 cacacgcgta tgcgcgccat aggcggcctg gcatccgtgg acgccgctcc gggcgagggc
    14461 gtgagagtgg agttgagatg gcccagctga tcaccgtcgc cgtggtcgac gacgaccgta
    14521 tgctcctcga cggtatccgg tcgtggttcg acggcgccgc ggggctgcgc ctcgtggcct
    14581 gtgcgcgcac cgtcgacgag ttgctcgcgg aacggcggga gccgccggac gtcgtcctgc
    14641 tggacctcat gctgcgcgac ggccgcccgc ccgcggagaa catccgcagg ctgcgggagt
    14701 ccggcagccg ggtgctgatg atcagcgtgg ttccggaccg cgaccggatc gtggccgccg
    14761 tcgccgacgg agccgacggc ttcatcacga aggaccacga tctgtccgtg ctcgtcgagg
    14821 ccgtccggga ggtcgccgcc gggcgcaccg cgcactcgcc ggagctggcc ttcgccctcg
    14881 cctacgaccg gggcgcccgc ccccggctct ccccgaagga gcgcgaggtg ctggtgggtt
    14941 acgcgtccgg gctcaccctg aaggcgacag cccgccgggc cggcatcacg gtcaacaccg
    15001 cgaagtacta cgtggaccgg gtgaagacga aataccagga agcggggcgc ccgacctaca
    15061 ccaagatcga cctcgcgacc cgggtccgcg aggacggctg ggtacacccc ggcaccccca
    15121 cggcctgaca ccccgtaacc cgcttcgccg gccggcggcc caccccggct ccgactccga
    15181 ctccgactcc gactccggct cccctcgccc cgctccctgg aacgtccctt ggcgcgaagc
    15241 acgccggaaa acgagtgtcc ccaggtcaga acgattctgc ctggggccgc tcggcggggc
    15301 gggtgggact cgaacccaaa agcgtgacgc ctctcacctg cggaaacgtc acagaggcgg
    15361 acattcacat cctgctggat cccgctgcat ccgcctcgat ccccggcaac cgcactgcgg
    15421 tgcggtacgt accgcacggc tacctggcgg cccctgcgcc tgtagtggga gacgatccgc
    15481 ccggcacatc tactgcaaca gacaagccga cggcgcaccc gcagcgcatg cctcagactc
    15541 cgttgccacc ccgccccttg acaggtgcag tcatactccg tatcgaccgg gcaccggaag
    15601 ccgggagcgt atcggttccg gcttccggcc gaacacgact cgggcgcttc gcgctggcac
    15661 ccgcccgcac gcctcagcgg ccaggacacg ggcgtcacct ttactgttac tgccagtatg
    15721 ggcgttcgaa ctttaagtgg gacagccgtg cgcccaaagc ttggctgtag tcggtgtccg
    15781 cgggaggggc tgacgggtct atagcgaacc cacgagagat gagtcgtgta ccgcgaacac
    15841 cgcatcacat cggctacgga cgctgtcgtc gtgggtcgcg atgaccactg agcatccgga
    15901 cttactcatg ccctcaagga tgtcgatgac catcgtgctg ttggcatcgt cgagagcgcc
    15961 ggtcggctcg tctgcgagaa cgacggttgg ctgctgaatc atgaggcggg ccagagccac
    16021 gcgctgctgt tctcctccgc tgaggtggga gatcttctct tcttcccgcc cggtcagacc
    16081 gacgcggtct agtacttcag ctagggacgt gttgtcaggg cgctgcgacg aacgccgcag
    16141 tttggtgact acttccaggt tctcatgcac tgtcgcggtc tcgatcaggg catagtgctg
    16201 gaacaggtag ccgagggtat cgcggcggta tcggcggata tcacgccgac cgaatcgggt
    16261 aatatctttc ccttcgtaac agatttcccc cttgtccggt cgctcgagca gccctagaca
    16321 gttgaggaga gttgacttac ccgatccact tgggccgatg agggccagca tttcaccgcc
    16381 gttaacggtg aagctgatgt cgctccacac ggtgcgggct ccgaatgatt tcgatagatt
    16441 ctttatatcg atcacgacgc actccgacta gtgaggaatt ccgtaacgaa aggcatcacc
    16501 cctcggtcgc cccttcttta attatgcggc ggtgaaagaa ggcaagggcg agaagcacgg
    16561 ctgccagttc gaagacgacg aggccggtga tgacgctggt atccaatgca gtgatgtgaa
    16621 cggcctcgaa gggggcaggc gcaccggccg cggcaaggtc gcgcaattct ctgttctgct
    16681 gccaattttc gaaaggcact ctactggcaa agattatcgc gattgccacc tctacagcga
    16741 gtatgaagcg gtgggtagca ctatacctcc aaccactgat gtgtcgcacg aaaatatttt
    16801 gggcgttctt ccgcgagtaa ataatgcaca cacctgcacc tgcgacaagc agcactatca
    16861 tggcgatgat gaggttgaat gtgtgcagtc ggaatttatt cgacgcttcc ctgaggtcca
    16921 gtgcagcttt ttgtccgacc gggctaacgg agctcacata gtttcgcagg gattgggacc
    16981 tgataccatt caacgcgtcg ttggggtcag gaaatactac gcccccctga gtagcgaatg
    17041 tcgcgtatgc atcgttcgta aggaatgatc cattggggac tacgataagg accgggtcgt
    17101 ccaccaatga tctgtcttcg tccgcgctgt gtgccgcgct gtaaacgttg gtaccggtgt
    17161 tgtatccgaa gacacgttgc cctgttttgc tggtgagcgt ttcgagcggg atgttccgac
    17221 tgagatgcgg gtcaattatc cgagaggccg cttgtgcgat gtcgggcgtg tgcgaggtca
    17281 gagactcagg aacgataacc cggacctggc tcgacttgct attaccattt ccggacgtgg
    17341 cagaataacg tcgaccattt atgccgataa ctgactgttc accaagatag gtgtcgttga
    17401 cgataagaat ctcaccggcc ggcagatgcg cttcgggaac ggacagttgg aggtctctac
    17461 gtccggaaac aatgacctca ccgcgctggt cggcctgacg tagccacggc cccacgtgct
    17521 tgtccaattc gtcaagttgc attgcaaagg cgccattgag gcgaattgag actgcatcgc
    17581 cgacagtgtc atagacctct cggttctcct gccgcgtgag aacatccctg gccgcgaagc
    17641 tgacatggcc ggcgatgctc agggcgagta gcagagcggg aatacgcacc aggtagacgc
    17701 tgatggatgc cgcccgtgat ggcagttcgc ccttgagggc aggcagcacg tcgaccttgc
    17761 acgtcaaggc gagcacggcc gcatgtgtgg cgagcaccag ggcgctgagc aggacggcga
    17821 tcacaacagc taccgacgtg aacagtccca gccaggcgaa accgttgtag aggcctagga
    17881 agcccagcgt ggtagtcgcc acaacgccag ctgccattag ccaggacacc ctcaactgtc
    17941 gcaggtcatg gagaaggatg ccggtgaagg acatgccctg cattcggagg actgcgtagg
    18001 tcttcacatt gagcagcacg ctcgcgccgg tcatcgtcag tgcagcgagg gcaactactc
    18061 cgagggcacg aaacaggggg tcgtccgtgt acgttttgga caactcttcg tatgacagag
    18121 ggtgtatgac gcttgcgacc atgccacggt cactgaaatc ggataccaga gcatcggctg
    18181 cctcggaaga cccgaacaca tagtacgagc ctcgcggatc ctgatgcccg atctctgata
    18241 gtggatgcac acgtgtgtca tatttctcac tgaaggccgg atagccctta cttagccatg
    18301 atgctgtcac ggtgccggcg tcgcccgtcg ccaagtacag atgccgacgc ccgtcagggt
    18361 tcttcagatc cggcacttcg cgacccaccg cgaccccgtg ctcggtcgcg aaagactcga
    18421 cgagtcgaac ggcttgagca gcactcaccg aatcgtccga gtcgagcacg gtgaccaaag
    18481 ccgagttccc tagaaccgtg ctctcatcca gcccccgcag aaacagaaaa ctcagtacta
    18541 cggagaaggc caatatggcg gcgtggacga atcttatacc tcggtgcagc atcggttatt
    18601 acctaggttg agggtgctcg gggagcacgc atccgaatag gctcagctga aaaaacagct
    18661 gtgagggcga gaggtactcg ccctcacagc taaattgagt taggcatgtt ggagcggcgc
    18721 cactcgcacg tgccgtaact cagtattcga ccggacgaac tagcagctcg ggtcgtagta
    18781 gtagttgata ctgccaccgt tcttggaccc ggaggccagg gaccacgaac ccggcgacgt
    18841 gcagccactc ctggaaagct ggccgccgat cgacaccgaa gaagcgtggt agttcgaggc
    18901 gtgcttgtag ttcgaccacg ccgtgttggc gccctggtcg tagctccagg tacccccacc
    18961 gacattgacg gtggtcgcca gcgcgggagt ggccgcggcg aggacgagac ccactgtcgc
    19021 aatggctgcc ttagccccgg tgcgcttgtt catgaatgtt ccccttttca tcatgacctt
    19081 gttcgcggac aaacaagatc ttgctacgga gagcggtcca gcctcaaccc tgagtgcatg
    19141 tgacgaaagt aactttataa tacatacaac tacgctcgcg ccgactggcg ttgagggtat
    19201 ggggtgacct caccggaggg tcgaaggaca ttttcagcta atgaagatgc acgttcaagc
    19261 caacgctggc tatttagcaa cctaagcact ggaatggtct cagccatagg gcatgattcc
    19321 ggccagaaag aaggaatcag tggccactgc gatggcatcc tgaagcgcgc tggatttcat
    19381 cgggccgcgc atcgcgggga ctagctgcat catccgtccg tcgctttggg acgccccgcc
    19441 gccacagaag ccctcgctca cgtccaggac cgcatgccgc ccgccgcacc cctacccgag
    19501 ggtctgaaaa cgctgatgaa ctccccaacg acccccgcgc gtcaccgcgt tctcgtctgc
    19561 ctgctcccga tggtgtggac actggctctc ggcctttggg gactgtcccg gcaggacagc
    19621 gtgtggcggg acgaagcggc cacctggcag gtggcccaac gctccacggc cgagatatgg
    19681 agcatgctgg ggaacgtcga tgtcgtacat ggctgctatt acctctttat gcacggattg
    19741 ttcgaatatt tcggccccag caccaccaca ctgcggttgc cttcggtgct ggccacagca
    19801 gtggcggctg cctgcgtggc agccatcgga caccggctag ccgggctttc cgtgggcctg
    19861 gcggggggac tggcgttcgg gctcctcccc gccgtgcagt tctatctcca ggagggccgc
    19921 ccgtacgcgc tggtcgcggc cggagccgga atctcgaccc tgctgctcgt gaccgcgctg
    19981 caggggcgca ctcagatgcc gcactggttc gcctacggtg ggacggtcct ggcgtgcggg
    20041 ctgctgaact ggctctcgct gatgatcctg ccggcgcact tgctcacgct gctctggacg
    20101 cgacccacgc tccgcatatc cgtacgctgg gcagccgctt ccgcggccgc gacggcgtgt
    20161 gtactgcccc tgatgctctt cagtcacagc cagtccgtac aggtctcatg gatcccgcca
    20221 ttgacctggc acatgctgat cggaccgacg gtccttctgc tgatcggcgg catcggagcc
    20281 gcactggatc ggcccagggc gggcgacctg tcggttgcgg ccgtcggact ccccctgctg
    20341 gctgtaccac aactcggcct ggccggcctc tccctgattc agccactgtt cttggaccgg
    20401 tacatactct tcagcctgct gggactggcg ctgctgatcg gttcgatcat cggctcggcc
    20461 gtacaagcag ccgcccccag gttcccgagg gcatcgaggt ggattctccc cgcagtggtc
    20521 gccctcgcgg tgatggcgct gctgccgcag gcgctggcaa aacgctcgcc ggcaagccgg
    20581 gtggacgacg tcctggcggc ggcgtcagaa gtacggctga tgaacgaacc tggaagtgca
    20641 gtgctcttca tcccgtcggc ccggcgggac accaaatccg tctcacccag cgcctttgcc
    20701 ggcctgcggg acatcgctct ggcacagagc ccggaggaat ccggaacact caagggtgtg
    20761 gaagcagacc cggaccagat tcgcgccgca atgcttgccc agcacagaat cgtgctggta
    20821 acagacgcat ctcaagtggc aaaaccggtg acagccaagc gggacaaact caagacctcc
    20881 gtgctgacga cgtacttcac ggtagtagcc gacgagcagg tccgcggcag gcgtgtaacg
    20941 gcctacgagc gacgcgcagc aactcactga ccccaacagc gcagcagctc atgcccggcc
    21001 ccggtatggg agacaggagc cggtcctgac cgcttggtgg tcgagaccga ggcctgcgtc
    21061 tgaaatggcg tatgcgcctc ccagatgcca gcgtgtaaac ggtcgtcccc tgtggtgaca
    21121 gcaggcggct gccccgtcct gtcggcagct tcggtccgac cacccgcctc accgctgatc
    21181 tctggctcgc tggccaatgg gccaccacaa ccgacaccgt cgggcgattt tgaggctgcc
    21241 cgcgccccgc aagaagcgat ccggctcccg gtctctctga cgcgaaagcc ccggctggtc
    21301 ggggagccag ccggggcagc tatgagtgtg ggtccggaga gcggtcggcg tccccggcgc
    21361 gaagatcagc caccgcggcg actggaccca cgatggctac gaagacctca tcacgctgcg
    21421 cagcgaatcc gccaccagcc gcctgtggat gcatccgaac accggcaccg gctacgcctg
    21481 tgccgactgc gtcaccggcg agcaggccca ggaactgggc gtctacgact ccgccaacaa
    21541 ccactggtcc accggcgcca agcagatcct cgcggtcggc gacgtcggcg gcggaaccga
    21601 caccgacggc gacggcaccg aagacgttcc cggctacccg gacatcatcg tcaacgacgg
    21661 tgaatacatc tggcgctact acggcaaccg cgatctgcgc cttggcagcg accgcgaccc
    21721 cgtcctcctt gccggccccg acgatcccat cgcctcaggc gactccaagg tcaacgaggt
    21781 gacgctcgcc gccccggcga cttcaacggc gacggacagg ccgatctcgt cgtccgctac
    21841 gaccgcccag acgtcggcgg gccttacgtc ttccacgggc atgaggacga ctacggctac
    21901 gacatcagcg accgcaccga gatcggagcc aactggagca caagcaccgt gccccagttc
    21961 accgccgcac ccgacgccca gaacaacggc aagttcgacc tctgggccac cacacacaac
    22021 tccggacgcc tccgaatctt cgccgactac acaacagccg gacacaccgc agtacttatc
    22081 gcatccaaag aactggccga ctaccaagcc atcagctgaa ccagtcccga acccctggcc
    22141 tcggcgctct gccggggcca cgctccgttt gggcagaccc gacgggtccc gacaagcgcc
    22201 agtacctccc cggcgaagat gtcctcttcg ccaccaggag aacaacgggg ccagaaaggt
    22261 ggatcaccag gacatctcgc cgcccagatg gcagccgtgg gaccgcgcca ctccactccc
    22321 tcggacaagc gccgcaaaag gccaggtcag aggcatctga agtgatctga cacgctgcga
    22381 cagcgggtca gtaccgcacc gtacgcggtt agtaccgcac cgaaaacagc cgtgaaattc
    22441 acgtttccgc aggtcagaac gtttccgcag ggtaaaactg gtggggcggg tgggactcga
    22501 acccacggcc gacggattat gagtccgctg ctctaaccgg ctgagctacc gccccgtatc
    22561 ggcgtggcgc gtacaagtgt gcgcaccgtc tgccgcagca tagccggtca tacgatctct
    22621 cgcttcggat ggtcgacttc gcctgaccat ggagacttcg ctgcgtgctg cctggttccg
    22681 ggtcggcgcg aggagacccg aaagtgtcac ggcgggcccc tgcgggtcgg tgtgcgggca
    22741 cgcgaaagag ggccccgagg ggccctctca cgtccgctcc cccgactgga ctcgaaccag
    22801 taaccctccg gttaacagcc gaatgctctg ccaattgagc tacaggggat cgcgctcccc
    22861 cgactggact cgaaccagta acctgccggt taacagccgg ctgctctgcc aattgagcta
    22921 caggggattg ctgcgtcgca tcgaatcgca cctgcctggc ggatgccggg cggcgcgcgt
    22981 tcgctgcgac acatacatta gcgcaagcag gggggtgctc cgccaatcgg taacgcccgg
    23041 ggtgatctcg ggcggtcgcg ggtaggcggc ctgcacacgt cgcacggagc gtaggagaag
    23101 ggtggcagcc atgcggtacc ggctcacgtt catcgccgga gtggccctcg gttacgtgct
    23161 cggcacgcga gccgggcgcg agcgttacga gcagttgaag aagtcggccc ggcagttcgc
    23221 cgggaatccg gccgtccgca acgccgccga gaccgccgcc cacagcgggc gggacatcgc
    23281 gggcaaggcg taccactcgg tcagcgacaa ggtcggggac cgggtgcccg cctccgtggc
    23341 ggaccgggtg cggtcgctcc gggaccgcag cagtcagaac ggcgaggacg actggggcac
    23401 caccaacacc tgactccggt ccgggctgcg gaccggtccg ggcggcggac gcggctcgcc
    23461 gccgtgcccg ccgcccggac cggggcccgg agccggttac gggatcgtcg cggggtgcgg
    23521 cagaatctgc gtatgggcat agtcgcgggg ttggacagtt catcggcctt cacgcacatc
    23581 gtcgtctgcg acacggacac gggcaccgtg ctgcgggagg gctatgccgc gcacccggtc
    23641 gaggccaagg cgtccgaggt cgatccgcag gtgtggctcc tctccctcgg tgaggcggcc
    23701 tccggcgggc tgctcgaagg cgtgcaggcc atcggcgtcg ccgcgcagca gcacggcctg
    23761 gtgccgctgg acggccaggg caatctcgta cggcccgcgc tcctcggcaa cgaccggcgc
    23821 gcgcaggtcg cggcggccga cctcgtcgac gggctgggcg ggcggcaggc ctgggctgag
    23881 gcggtcgggg cggtgccgca ggccgcgcag ccggtggcga agctgcgctg gctggcgcgg
    23941 accgagccgg agaacgcgca gcgggtcgcc gccgtcctcc agccgcacga ctggctcgtc
    24001 tggcagttgc tgggccggcc cgcccggcgg accacggacc ggggcgccgc ctc
//
