LOCUS NZ_ML123034 11194 bp DNA linear CON 23-MAY-2024 DEFINITION Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun sequence. ACCESSION NZ_ML123034 VERSION NZ_ML123034.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. ADI96-02 ORGANISM Streptomyces sp. ADI96-02 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Streptomyces spp. from the marine sponge Antho dichothoma: analyses of secondary metabolite biosynthesis gene clusters and some of their products JOURNAL Unpublished REFERENCE 2 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Direct Submission JOURNAL Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1, Bielefeld 33615, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.8 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 64.8x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_003846185.1-RS_2024_05_23 Annotation Date :: 05/23/2024 03:48:04 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,089 CDSs (total) :: 6,032 Genes (coding) :: 5,843 CDSs (with protein) :: 5,843 Genes (RNA) :: 57 tRNAs :: 54 ncRNAs :: 3 Pseudo Genes (total) :: 189 CDSs (without protein) :: 189 Pseudo Genes (ambiguous residues) :: 0 of 189 Pseudo Genes (frameshifted) :: 68 of 189 Pseudo Genes (incomplete) :: 155 of 189 Pseudo Genes (internal stop) :: 10 of 189 Pseudo Genes (multiple problems) :: 42 of 189 CRISPR Arrays :: 2 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 01:00:53 NOTE :: This is a single region extracted from a larger record! Orig. start :: 132205 Orig. end :: 143399 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to ML123034.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Zotchev Lab, Department of Pharmacognosy, University of Vienna. Annotated using prokka v1.11 from http://www.vicbioinformatics.com. FEATURES Location/Qualifiers region 1..11194 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="1" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..11194 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..11194 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:6194](+)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core 5001..6194 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" gene complement(470..1942) /locus_tag="EES43_RS00530" /old_locus_tag="EES43_00530" CDS complement(470..1942) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020548159.1" /locus_tag="EES43_RS00530" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00530" /product="N,N-dimethylformamidase beta subunit family domain-containing protein" /protein_id="WP_124266787.1" /transl_table=11 /translation="MTDGKALPRPVVDGYPGRPSVRAGEVLRLHVSTRAERFRADFYRC GPRPRLMGRTRGRGAYAEPGSHDADWNWPVHDVAIPADWPSGVYIAVLGPDAESPDITS PDTTSPDITSPDEAGPDARFRDARRPVDAAALDARHSRLLFVVTAREPGHRARILYKVP LFTYHAYNRSGGASLYGALPGTEDRRTVTLRRPGGGIGGPVKGRPDAHDPATPRQTFAH WDAPFIAWLEAAGFTADYCTDLDLDENPELAHPYRLLLSAGHDEYWSGRVRRHTSSFRD RGGNIAIFGANTCWWRVTPDATGTAVSCAKYPPGVPQGADTDRMRGAPDHWWEEEPENR LIGVSYRNGGGHWDGLRERLGFTVQHTGHPVFAGTGLRDGDVLGAEHHLVGYECDGAAH RRDAHGRAVATGEDGTPEDFTILGVADLPAAPGSGWHTAARENDDPGRAATFGLYTRGG TVFNAATTDWPRLLRLDPRVRTITRNVITLLT" gene complement(1939..3078) /locus_tag="EES43_RS00535" /old_locus_tag="EES43_00535" CDS complement(1939..3078) /EC_number="2.4.-.-" /GO_function="GO:0016757 - glycosyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Glycos_transf_1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1045: glycosyl transferase group 1" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF012744.4" /locus_tag="EES43_RS00535" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00535" /product="glycosyltransferase family 4 protein" /protein_id="WP_124266788.1" /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-16, bitscore: 58.1, seeds: 63, tool: rule-based-clusters)" /transl_table=11 /translation="MRIAYLHGGGIPSPFANGVHVMRMCDAFAAAGHQVTLYSIPGTDE EPYAYYGVRHRFPIRLVACPDYTPSGYRKRAEAVRALVADGPAPDLVYGRDPYALSALA DLAPLVYEIHQLREDLSPAGTEEALLAAPRLVRVVAITHALARDVRDKYAALGPLPIVV APDCADPPGPAPADPLPLPGRPDALRVGYVGHLYDGRGIGLVLELAERFPALDFHLVGG TDEDRTRWQQVCRSPHAHFHGHRPPSELSGYYARFDVVLAPYERKVYTWGRLGETGRWA SPMKVFEYMSHGCPMIASDLPVLREVLQDRVNCLLRPPEDADAWAGALNELAADPALRR GLGAEGRRQVLERYTWRRRADVVLAGLGAVETVRPEPAA" misc_feature complement(3306..3326) /note="TFBS match to MntR, Manganese transport regulator, confidence: weak, score: 18.84" /tool="antismash" gene 4033..5004 /locus_tag="EES43_RS30425" /old_locus_tag="EES43_00540" CDS 4033..5004 /codon_start=1 /inference="COORDINATES: protein motif:HMM:TIGR04267.2" /locus_tag="EES43_RS30425" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00540" /product="HEXXH motif-containing putative peptide modification protein" /protein_id="WP_164493085.1" /transl_table=11 /translation="MRVEPDAREGAEERSALALMARTALERVGLEVSPREAAHPAVVEA AHIAQYVLRTGPPVPERLTRLTGMLDRARSDGTGTRPSALPWPTGLAAPGPHLERSVAR ALKSVPDRGAGAGAPRGSSVAGWRAPEEEAARSAVALLESAWPGVAGELSTVLVQIALL DGPGIDGFTDFTVHGAVFVRRDRLAPDADGLPGSVRFAEALVHEGAHTRCNAASVADRP FLRPLEESGPMVATPLRLDPRPLTGLFQQMVVLARSVLLYRRLLAREAGGVGAAPAVRA RHDRLAHSAAEAVRTMTLHRDTLTEHGAAMLEDAAEAARVRV" gene 5001..6194 /locus_tag="EES43_RS00540" /old_locus_tag="EES43_00545" CDS 5001..6194 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: YcaO" /gene_kind="biosynthetic" /inference="COORDINATES: protein motif:HMM:NF014661.4" /locus_tag="EES43_RS00540" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00545" /product="YcaO-like family protein" /protein_id="WP_164493086.1" /sec_met_domain="YcaO (E-value: 1.6e-35, bitscore: 121.8, seeds: 127, tool: rule-based-clusters)" /transl_table=11 /translation="MTAASAWAPQVFAPYASWPRVVLARVAARSPQFDAVCAAGGRPVI VGSAAGHDSERVAASARGELLERVGNVLAGRAAESDAAVVASHRELRRKGIPAVDPAEL APDGGAAALDDAREARRLWVRGRFLRSGADVHVPAGAVFLHHRAPSGCDPGPGAGSTGL AAHPDPEAATRHAAWEVLERDLVRRSWYGLLPGPRVMASARLPEPLAELLDGNAISATA LDLPAPAGSRCVAVALHAADGTRQTFGARCGPEAEGVAPLAEKAAYEALMVRWSMKTAV AEQTWARWRGESPPGSAVEHALWAFHRQDSLRLWTARAPRSRGRRETAPAGRHRDGTAV LAEHTGRDPVVVDTTCGPANDLGSTVVRIVAPGARALPTGPDTERGLPIAPGPHPFG" gene 6390..7145 /locus_tag="EES43_RS00545" /old_locus_tag="EES43_00550" CDS 6390..7145 /EC_number="2.1.-.-" /GO_function="GO:0008168 - methyltransferase activity [Evidence IEA]" /GO_function="GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1248: methyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF024880.4" /locus_tag="EES43_RS00545" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00550" /product="class I SAM-dependent methyltransferase" /protein_id="WP_124266789.1" /transl_table=11 /translation="MTTYHERPAVPAGRYSDDHAADYDRWFGKPGITAATVDTLALLAG EGRVLELGVGTGRIALPLARRGFEVHGVEASQAMAARLRAKPGGEGVRITLGDFAEVPV EGVFSLILVVGGTLFELPSHEDLQRCLTAAAEHLEPEGVLVLDAHVPEALAVAAASGVP EVVSESDDHLILCHRRIDPSTATYHSHYLVHEADRTHHLRVRFHYASPGELDLMAERAG LRLRTRLGSWAGGPFTRGSAYHVSVYERR" gene 7215..>7624 /locus_tag="EES43_RS30430" /pseudo="" CDS 7215..>7624 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="EES43_RS30430" /note="incomplete; too short partial abutting assembly gap; missing C-terminus; Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /product="cytochrome P450" /pseudo="" /transl_table=11 /translation="MTDIDADGPVPTADFPFPHHDGLGPLPELAALRRDAPCARIVLPS GDPAWLVTRYADVRTVLADPRFSRRRATRGAGPRMARVPTLRDSILAADPPEHSRLRKL VAPAFTARRAEAMRSGVARLVDELLDRLAAHE" assembly_gap 7625..7649 /estimated_length=25 /gap_type="within scaffold" /linkage_evidence="paired-ends" gene <7650..8463 /locus_tag="EES43_RS00550" /old_locus_tag="EES43_00555" CDS <7652..8463 /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /GO_function="GO:0005506 - iron ion binding [Evidence IEA]" /GO_function="GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=2 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1007: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF012296.4" /locus_tag="EES43_RS00550" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00555" /product="cytochrome P450" /protein_id="WP_164493088.1" /sec_met_domain="p450 (E-value: 2.5e-13, bitscore: 48.0, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="RLAAHERPADLVPLLARPLPLAVICDLLGVPREDGDRLDAWCDAL RNLTAAPDAEVTAAVGEMTGYLTGLVAAKRRRGGDDVLSTLIAARDEGDRLSQDELVSF ALVLLAGGYGTTADRLAGSVHLLLDDPARYGQLVREPATIPRAVEELLRYAQTNVQANL RVATEELRIGGVRIAEGEAVMAINSSANHDENVFDAPDLLDLARERNPHLGFGHGVHHC VGAQIARVQLQEALAGLVRRFPGLRAAGPTEWKTGLKTRGPRSLPVSW" gene 8471..8743 /locus_tag="EES43_RS00555" /old_locus_tag="EES43_00560" CDS 8471..8743 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014628745.1" /locus_tag="EES43_RS00555" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00560" /product="ferredoxin" /protein_id="WP_124266791.1" /transl_table=11 /translation="MPREGEPRTARAAGPEAAARVFVDPALCIGSGICLATAPRHFEPG GDNRSRARPDAPASDESAEDAAALCPVEAIGLVAGPPAPGPPPGP" gene 8795..9616 /locus_tag="EES43_RS00560" /old_locus_tag="EES43_00565" CDS 8795..9616 /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1039: aldo/keto reductase family oxidoreductase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006345543.1" /locus_tag="EES43_RS00560" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00565" /product="aldo/keto reductase" /protein_id="WP_124266792.1" /transl_table=11 /translation="MRTLTLGNGVSVPRLGLGVWPLTDAQAYAAVSHALACGYRHFDTA RVYDNEAGVGRAIRDAGIPRQDVFLTTKLWNADQGYDAALRAFDAALQRLGTDYVDLYL IHWPVPEQDLYVESYRALEQLHRDGRARAIGVSNFTAATLERLLSCTDVVPALNQIELH PYFQQRRMRESCALRSIATGAWSPLAQGGALLDEPVLLGIAGRHGKTAAQVVIRWHLQL GHVVIPRSVNPSRIEENIDVFDFRLGDEEMRAIAALDDDGGRIGPDPDGPG" gene complement(9935..10540) /locus_tag="EES43_RS00565" /old_locus_tag="EES43_00575" CDS complement(9935..10540) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family DNA-binding response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018839273.1" /locus_tag="EES43_RS00565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_00575" /product="response regulator transcription factor" /protein_id="WP_124266793.1" /transl_table=11 /translation="MIRVLLADDEHLIRGALASLLGLEDDIDVVAQAGTGDEALAMAVA HRPDVAVLDLRMPVLDGVVVAERLRDTLPGCASMIVTSHAGPGALKRALSVGVRGFVPK TVSARELARIIRTVHTGSRYIDQELAADAIAAGESPLTPREAELLAYAEDGAPVSDIAS RASLSAGTVRNYLSAAAAKLGAENRHVAARIARERGWL" misc_feature complement(10959..10977) /note="TFBS match to FuR_variant_2, Ferric Uptake Regulator, confidence: weak, score: 20.57" /tool="antismash" ORIGIN 1 cgtcctcgac gtaggagtcg ccggtgatca ggcggctgac ccgttccttg tccacgtcgt 61 ggccgacgac ctggtatccg ctcgcggcgg cccgtacggc cagggacagt ccgacgtagc 121 cctgtccgac gacgaccacg cggccgggga ccgggcgggc ctgcgggtcg ggcgtcgcgg 181 tgccgcgcgg caccgccccg tccggggcgg ccgggttcac ctcgcctccc cgcatccgtg 241 ccgtcgtggg ccggccgccc cgggcgccgg tccgttcggg gcgtggaggc gtgcggtgcg 301 ggtcctgccg cgcgtggtcg ccgcgcgagc gctgcgaccg gccgtgccgg gccgtacggg 361 catgagtggt cccctccggg cgggttcccg ccctgtgcga gtgggcgcag gacgctcgcc 421 ctgcgtgaaa ccggtgtgcg cggtgcggaa cggccgcggg cggcggacgt caggtgagca 481 gggtgatcac gttgcgggtg atggtccgca cgcgggggtc cagacgcagg aggcgcggcc 541 agtcggtggt ggcggcgttg aagacggtgc cgccgcgggt gtagagcccg aaggtggcgg 601 cccgccccgg atcgtcgttc tcgcgtgcgg cggtgtgcca ccccgatccg ggagccgcgg 661 ggaggtccgc gacgcccagg atggtgaagt cctcgggggt tccgtcctcg cccgtcgcca 721 ccgcccggcc gtgcgcatcg cgccggtgcg ccgctccgtc gcattcgtag cccacgaggt 781 ggtgctcggc gcccaggacg tcgccgtcgc gcaggccggt gcccgcgaag accgggtgtc 841 cggtgtgctg gacggtgaag cccagccgct cgcggagtcc gtcccagtgt ccgccgccgt 901 tgcggtagct gacgccgatg agccggttct ccggctcctc ctcccaccag tggtcggggg 961 cgccccgcat ccggtcggtg tcggctccct ggggcactcc gggcgggtac ttggcacagc 1021 tgacggcggt gcccgtcgcg tcgggcgtca cgcgccacca gcaggtgttg gccccgaaga 1081 tcgcgatgtt gccgccccgg tcgcggaagg aggaggtgtg ccggcggacc cgcccgctcc 1141 agtactcgtc gtgccccgcg gacagcagca gccggtaggg gtgggcgagt tcggggttct 1201 cgtcgaggtc gaggtcggtg cagtagtcgg cggtgaatcc cgccgcctcc agccacgcga 1261 tgaacggcgc gtcccagtgg gcgaaggtct ggcggggcgt tgccgggtcg tgcgcgtcgg 1321 gcctgccctt caccgggccg ccgatcccgc cgccgggacg ccgcagggtg acggtgcgac 1381 ggtcctcggt cccggggaga gcgccgtaca ggctggctcc gccgctccgg ttgtaggcgt 1441 ggtaggtgaa gagcggcacc ttgtacagga tgcgggcccg gtggccgggt tcacgggccg 1501 tcaccacgaa cagcagccgc gagtggcggg cgtccagggc ggctgcgtcg acgggccgcc 1561 gggcgtcgcg gaaccgggcg tccgggcctg cctcgtcggg gctcgtgatg tccgggctcg 1621 tggtgtcggg gctcgtgatg tccgggctct cggcgtccgg gccgagcacg gcgatgtaga 1681 cgcccgaggg ccagtccgcg gggatcgcga cgtcgtggac gggccagttc cagtccgcgt 1741 cgtggctgcc cggctccgcg tacgcacccc gtcctcgcgt acgtcccatg aggcgcgggc 1801 gcgggccgca gcggtagaag tcggcccgga agcgttcggc acgcgtcgag acgtggagcc 1861 gcaggacctc cccggcccgc acgctcggcc gcccggggta gccgtccacc accggccggg 1921 gcagggcctt cccgtccgtc atgccgcggg ctccgggcgg acggtctcca cggcgccgag 1981 gccggcgagg acgacgtcgg cccgccgtcg ccaggtgtag cgctccagga cctgccgccg 2041 cccctcggcg ccgagccccc ggcgcagggc cgggtcggcg gccagttcgt tcagcgctcc 2101 cgcccaggcg tccgcgtcct cgggcgggcg gaggaggcag ttgacccggt cctggaggac 2161 ttcccgcaga accggcagat cggaggcgat catggggcat ccgtgggaca tgtactcgaa 2221 caccttcatg ggcgaggccc agcgccccgt ctcccccagc ctcccccacg tgtacacctt 2281 gcgctcgtaa ggggcgagga cgacgtcgaa gcgggcgtag taaccggaca gttcggacgg 2341 cggccggtgg ccgtggaagt gcgcgtgcgg ggaacggcac acctgctgcc agcgggtgcg 2401 gtcctcgtcc gtgccgccga ccagatggaa gtcgagcgcc ggaaaccgtt ccgccagttc 2461 caggacgagg ccgatgccgc gcccgtcgta gaggtgaccg acgtagccga cgcgcagggc 2521 gtccgggcgg cccggcagcg gcagggggtc ggccggggcg gggccgggcg ggtccgcgca 2581 gtccggcgcg accacgatgg gcagcgggcc cagggccgcg tacttgtccc gtacgtcgcg 2641 tgcgagggcg tgggtgatcg cgacgacgcg gaccagccgg ggcgcggcga gaagcgcttc 2701 ctcggtcccg gccggggaca ggtcctcgcg cagttggtgg atctcgtaca cgaggggcgc 2761 gaggtcggcg agggcggaca gggcgtaggg gtcgcggccg tagacgaggt caggggccgg 2821 gccgtccgcc accagcgccc ggacggcctc ggcgcgcttc cggtagccgg agggcgtgta 2881 gtcggggcag gcgacgaggc ggatcgggaa gcggtggcgc acgccgtagt aggcgtacgg 2941 ctcctcgtcc gtgccgggga tggagtacag ggtcacctgg tgcccggcgg cggcgaacgc 3001 gtcgcacatc cgcatgacgt ggacgccgtt ggcgaagggg gaggggatgc cgcccccgtg 3061 caggtacgcg atgcgcatgc ggcctagccc cgtgcggccg ttgcggcggg cgcggtccgg 3121 cgctcggcgc accgggggcg gtgaggcgtg gtgtgcgtcg gatccacggg cgactcctca 3181 ggacggcgcg acgacgggcg gtgccggtcc ggtgacgcgg cagcggtccg gccgcccgga 3241 ggggcggagc gcgcggtgag acggggcgag gcggtagggc ggggcggatc gggtcggcgg 3301 cggagcaccc cgccggagcg gtgtttcgcc tggcctgcgc cgggacgggg cagatgacga 3361 agcatcatgc tgcgtggtgc cgggcttttc caagagtggt ctttcggccg tttcgacagt 3421 cctgtttgcg ccgctctccg ccgcacgggg cccggctcgt ggcaccggtg cgcgaccacc 3481 ggcgcacccc tccggcgtcg acggggcagg ccctcccggc accttccgga cagaaaagtg 3541 tccgagacgg aaccgatgac acagcgggac atgatgtgcc ccggcgcgtc ctcccgaacc 3601 ggcggcgggc ggtccacggg gcacggtgga ccggaccggc ggaccggaac ccgcaggcca 3661 cggagcgcgc ggcgccggcc gccgaccgct cggagcgccg gacggcgaca cggatgccgc 3721 ggcacgccca ccgcccggac gggccgccgc gcgtacgtcg cggggaacgg gccctacctt 3781 gtgctcggtt ccggcccgtg cctaccgtgg ctgcgccgtg actccccgtc aacgtcggag 3841 gaggcggtca tcgaagggag atcgatatga acgaggagat cgagcagatt cccgaggaag 3901 aacttcccga actggcgctg atggtcgaca ttcccagctg acgccgcgcg cccggggcgg 3961 cggacctcac cggtccgccg cccgcccgct cactgctccc ccgctcctac gtcagcacgg 4021 aggtcacgca cggtgcgagt ggaaccggac gcgcgcgagg gcgccgagga gcgcagcgca 4081 ctggcgctca tggcgcgcac agctctcgaa cgggtaggtc tggaagtctc cccgcgggag 4141 gccgcgcacc ccgcggtggt cgaggcggcg cacatcgccc agtacgtgct gcggaccggg 4201 ccgcccgtgc ccgaacgtct cacccggctc accggcatgc tcgaccgcgc ccgctcggac 4261 ggaacgggca cccgtccgtc ggcacttccg tggccgaccg gactcgccgc accgggaccg 4321 catctggagc gcagtgtcgc ccgcgcgctg aagtccgtac cggatcgagg agccggggcc 4381 ggcgcaccgc gcggctcctc ggtggccggg tggcgcgcac ccgaggagga ggccgcccgc 4441 agcgcggtcg ccctgctgga gtcggcctgg ccgggcgtgg cgggcgagtt gagcaccgtg 4501 ctcgtgcaga tcgccctgct ggacgggccg ggcatcgacg gcttcacgga cttcaccgtc 4561 cacggcgccg tcttcgtgcg gcgcgaccgt ctcgctccgg acgccgacgg gctgccgggt 4621 tccgtccggt tcgccgaagc gctcgtccac gagggcgccc acacgcggtg caacgccgcg 4681 tccgtggcgg accggccctt cctgcggccc ctggaggaga gcggcccgat ggtcgccacg 4741 cctctccggc tcgatcccag gccgctcacc ggactcttcc agcagatggt ggtcctggca 4801 cgcagcgtcc tgctgtaccg gaggctgctc gcccgggaag cgggcggcgt cggagcggcc 4861 ccggccgtgc gggcgcgcca cgaccggctc gcccactcgg ccgcggaggc ggtccggacc 4921 atgacgctcc accgcgacac gctcaccgag cacggggcgg cgatgctgga ggacgccgcc 4981 gaggcggcgc gggtgcgggt gtgacggccg cgtccgcctg ggcgccccag gtcttcgccc 5041 cgtacgcctc ctggccccgg gtcgtcctcg cccgcgtggc ggcgcgctcg ccgcagttcg 5101 acgccgtctg cgccgcgggg ggccgtccgg tgatcgtggg cagcgcggcc gggcacgact 5161 cggaacgcgt cgcggcgagc gctcgcggcg aactcctcga acgcgtcggc aacgtgctcg 5221 cgggccgcgc cgcggagtcc gacgcggcag tggtcgcctc ccaccgggag ctgcgccgca 5281 aggggattcc cgcggtcgac cccgccgaac tcgcgccgga cggcggggcg gcggcgctcg 5341 acgacgcccg cgaggcccgc aggctgtggg tgcgcgggcg cttcctgcgc tccggggcgg 5401 atgtgcacgt gcccgccggg gcggtcttcc tgcaccaccg ggctccgtcc ggatgcgatc 5461 ccggtccggg cgcgggctcc accggcctgg ccgcccatcc cgatccggag gcggccacgc 5521 ggcacgccgc ctgggaggtt ctggagcgcg acctcgtccg caggagctgg tacggcctgc 5581 ttccgggccc gcgcgtgatg gcctcggcga ggttgccgga gccactggcc gaactcctgg 5641 acggcaacgc gatctcggcc accgcgctcg atctgcccgc gcccgccgga tcgcgctgcg 5701 tcgcggtggc cctgcacgcg gccgacggaa cgcggcagac gttcggagcc cgctgcggcc 5761 cggaggcgga gggcgtggcc ccgctggccg agaaggccgc ctacgaggcg ctgatggtgc 5821 gctggagcat gaagacggcg gtggcggagc agacgtgggc gcgctggcgg ggcgagagtc 5881 caccgggctc cgccgtcgaa cacgcgctgt gggcctttca ccggcaggac agcctccggc 5941 tgtggacggc acgcgccccg cggagccgcg gccggcgcga aacggctccc gccggtcggc 6001 accgggacgg gacggccgtg ctcgccgagc acaccggccg ggacccggtc gtcgtggaca 6061 ccacctgcgg accggcgaac gacctggggt cgaccgtcgt acggatcgtg gctccgggag 6121 cccgtgccct gccgaccggt ccggacacgg aacgcggcct tccgatcgcg ccgggccctc 6181 atcccttcgg atgacccgcc cacctcatcc cgcccgtcct cacccggccc gagcccgatc 6241 ccgacccgtc cgcccgcccg tccgttcacc tgctcgtccg ttcgtccgct catctgccca 6301 ccaccaccgc cgccagtcag ccaccacatc cgcgtcgacc gccgctcggt acggcgaccg 6361 gaccgacccg caggccgagg agccccggca tgaccaccta ccacgagcga ccggccgtcc 6421 cggcgggccg gtactccgac gaccacgcgg ccgactacga ccggtggttc ggaaagccgg 6481 gcatcaccgc ggcgaccgtg gacaccctcg cgctcctcgc cggcgagggc cgggtgctcg 6541 aactcggtgt cggcaccggc aggatcgcgc tgcccctggc ccggcgcggc ttcgaggtcc 6601 acggcgtcga ggcgtcgcag gcgatggcgg ccaggctccg ggcgaaaccc ggcggggagg 6661 gcgtccggat cactctgggc gacttcgccg aggtgcccgt cgagggcgtg ttctccctca 6721 tcctggtcgt gggcggcaca ctgttcgagc tcccctccca cgaggacctt cagcggtgcc 6781 tgaccgccgc ggcggagcac ctcgaaccgg agggcgtcct cgttctcgac gcccatgtgc 6841 ccgaggcgct ggccgtcgcc gccgcgtcgg gggtgcccga ggtggtctcc gagtccgacg 6901 accatctgat cctctgccac cgcaggatcg acccgtccac cgccacctac cactcccact 6961 acctcgtcca cgaggcggac cgcacccacc acctgcgcgt ccggttccac tacgcgtcac 7021 cgggcgagct ggacctgatg gccgaacggg cggggctccg gctgcgtacg cgcctggggt 7081 cctgggccgg ggggccgttc acccgtggca gcgcctacca cgtctccgtc tacgaacgcc 7141 gctgagacct cccctgccgt acgcggtcgt cgacgcccgg cgtccgcacc gccgagaacc 7201 ctcccggagc agtcgtgaca gacatcgacg cagatggccc ggtccccacc gcggactttc 7261 ccttcccgca ccacgacggg ctgggtccgc tgccggagct ggcggccctg cgccgcgacg 7321 ccccgtgcgc ccggatcgtc ctgcccagcg gcgacccggc atggctggtc acccgctacg 7381 ccgatgtgcg caccgtgctg gccgatccgc gcttcagccg taggcgcgcc acccggggcg 7441 cggggccccg tatggcgcgt gtcccgaccc tgcgggactc gatcctggcg gcggacccgc 7501 ccgaacacag ccggctgcgc aaactggtcg ccccggcctt caccgcccgg cgcgccgagg 7561 ccatgcggtc cggtgtggcc cggctcgtgg acgagctgct ggaccggctc gccgcgcacg 7621 agcgnnnnnn nnnnnnnnnn nnnnnnnnnc cggctcgccg cgcacgagcg gcccgccgat 7681 ctcgttccgc tgctcgcccg gccgctcccg ctggccgtga tctgcgacct gctcggtgtc 7741 ccccgggagg acggcgatcg gctcgacgcc tggtgcgacg ccctgcgcaa tctgacggcc 7801 gccccggacg cggaggtcac ggccgccgtc ggggagatga ccggttacct gaccgggctc 7861 gtcgcggcca agcgccggcg aggcggcgac gacgtgctga gcaccttgat cgccgcacgg 7921 gacgagggcg accggctcag ccaggacgag ctggtctcct tcgctctcgt gctgctagcc 7981 gggggctacg gcaccacggc cgaccggctc gccggctcgg tgcacctgct gctggacgac 8041 cccgcgcggt acggacagct ggtccgcgaa ccggcgacga tcccccgcgc cgtcgaggaa 8101 ctgctgcgct acgcccagac caacgtgcag gccaacctgc gggtcgccac cgaggagctc 8161 cggatcggcg gcgtccggat cgccgagggc gaggccgtga tggcgatcaa ctcgtcggcc 8221 aaccacgacg agaacgtctt cgacgccccc gatctcctcg acctggcccg cgaacgcaat 8281 ccgcatctcg ggttcggcca cggcgtccac cactgcgtcg gcgcccagat cgcgcgcgtc 8341 cagctccagg aagccctggc cgggctcgta cgccggttcc cggggctgcg cgccgccggg 8401 ccgaccgagt ggaagaccgg tctgaagacg cggggacccc gcagcctgcc cgtgagctgg 8461 tgaggcggtc gtgccccgtg aaggcgagcc ccgtacggct cgtgcggcag gcccggaggc 8521 cgcggcccgg gtcttcgtcg acccggccct gtgcatcggg tccggcatct gcctcgccac 8581 cgcgccccgg cacttcgaac ccggcgggga caaccgctcg cgggcacggc ccgacgctcc 8641 ggcgtcggac gagtcggccg aggacgcggc ggccctgtgc ccggtggaag ccatcggcct 8701 cgtcgccggg ccgcccgcgc caggcccgcc gccgggcccc tgacagccgg cggctcgacg 8761 acgcccccgt acccgtaccc ggaaggatcg ccgcatgcgg acactgaccc tcggcaacgg 8821 ggtgtccgtc ccccggctcg gcctcggcgt ctggccgctg accgacgccc aggcgtacgc 8881 cgccgtctcg cacgccctgg cctgcggcta ccggcacttc gacaccgccc gggtgtacga 8941 caacgaggca ggggtcggcc gcgcgatccg ggatgccggg atcccgcggc aggacgtctt 9001 cctcaccacc aagctctgga acgccgacca gggctacgac gccgcactgc gggccttcga 9061 cgccgccctc cagcgcctgg gcacggacta tgtcgacctc tacctgatcc actggcccgt 9121 tccggaacag gacctgtacg tcgagtccta ccgggcgctc gaacagctcc accgcgacgg 9181 acgcgcacgg gcgatcggcg tctccaactt caccgccgcg accctggaac gcctgctgtc 9241 gtgtaccgat gtcgttccgg ccctcaacca gatcgagctc cacccctact tccagcagcg 9301 ccgcatgcgg gagtcgtgcg ccctcaggtc catcgcgacc ggcgcgtgga gcccgctggc 9361 ccagggcggc gcgctgctcg acgagcccgt gctgctgggc atcgccgggc ggcacgggaa 9421 gacggcggcc caggtcgtca tccgctggca cctccagctc ggccatgtgg tgatcccccg 9481 gtccgtgaac ccgtcacgga tcgaggagaa catcgacgtc ttcgacttcc ggctcggcga 9541 cgaggagatg cgcgcgatcg ccgccctcga cgacgacggc ggccggatcg gccctgatcc 9601 ggacggaccg ggttgatgtg gcgagtctgg tcgatgcccg gggggcgttc gatgtggggg 9661 ccacatggcg tgcgaccccc ggggcctgtc gaggggtggc tcggaagcgg ttcgaggggc 9721 gcggcagcca gggcttgtgg gtcccggagg tgcggggcgc gaccggtgcg cggacggtgt 9781 ccttcaccgc gagcttcccg gtgatcagag aggacttctc cagcgcgtcc gcacacgcgt 9841 tcccgctcag gaggtagacc ccgtggccct ccccgtcctt gacggtcacc accttcgagc 9901 ggcacctccc gggcgaaggg gcggaagcgg gctctcagag ccatccgcgt tcgcgcgcga 9961 tgcgggcggc gacatggcgg ttctcggcgc cgagcttcgc cgcggcggcc gagaggtagt 10021 tgcgcacggt cccggcggac agcgacgcgc gggacgcgat gtcgctgacc ggcgcaccgt 10081 cctccgcgta cgccagaagc tccgcctcgc ggggcgtcag gggcgactcg cccgcggcga 10141 tggcgtcggc cgcgagttcc tggtcgatgt agcggctgcc cgtgtgcacg gtgcggatga 10201 tccgcgccag ttcccgcgcg gacaccgtct tgggtacgaa gccgcgcacc ccgacgctca 10261 gggcacgttt cagcgccccc ggaccggcgt ggctggtgac gatcatcgag gcgcagccgg 10321 gcagggtgtc gcgcagccgc tccgcgacca cgacaccgtc caggacgggc atccggaggt 10381 cgaggacggc gacgtcgggg cggtgcgcca cggccatggc cagcgcctcg tcgcccgttc 10441 cggcctgggc gaccacgtcg atgtcgtcct ccagtccgag gagcgaggcg agggcaccgc 10501 ggatcaggtg ctcgtcgtcc gccagcagga ccctgatcat gcgtctgcct cccatggaat 10561 gcgcacggtc aggtggaaga ccccgcccgg ccgccgttcg gtgaccagcg tgccgttcag 10621 cgcggacagg cgttccctca ggcccggcag cccggtgccg ggcccctccg ccgcctcggg 10681 cgccccgtcg ttctccacca ccagcagcac cgcgcccggc ccggccgtgc gcagcgacac 10741 gttgcagcgt gaggctccct gggcgtggcg gagcacgttc gtcgtcgcct cgcgcaccgc 10801 ccagccgagt gcggcctgga tgtcggaggg cagccgggcg gcggggccct cctcgatgcg 10861 gcaggtgatg cccgccgctt ccagcaccga acgggcgccg gccagttcgg tgtgcagatc 10921 ggcggtgcgg tagccgcgca ccaccgaccg gatctcccgc tgcgagtcct gcgcgatgcg 10981 ctgcacctcc ctcatctgct cctcggcctc cggcctgcca cgccgcacca gttgcaccgc 11041 gagttcgctc ttgagcgcga cgaccgcgag attgcggccc agcacgtcgt gcaggtcgcg 11101 gccgaagcgc agcctctcct cggccacggc gagccgggtc tgcgtctgcc gtgccgcggc 11161 cagttcctcg acgagccgga cgctccagcc gctg //