LOCUS       NZ_RIAS01000009        20873 bp    DNA     linear   CON 13-MAY-2024
DEFINITION  Paenibacillus amylolyticus strain 27C64
            NODE_9_length_283810_cov_23.1148_ID_17, whole genome shotgun
            sequence.
ACCESSION   NZ_RIAS01000009
VERSION     NZ_RIAS01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus amylolyticus
  ORGANISM  Paenibacillus amylolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 283810)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Paenibacillus amylolyticus 27C64 has a diverse set of
            carbohydrate-active enzymes and complete pectin deconstruction
            system
  JOURNAL   J Ind Microbiol Biotechnol 46 (1), 1-11 (2019)
   PUBMED   30377865
REFERENCE   2  (bases 1 to 283810)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2018) Microbiology, University of Georgia, 120
            Cedar St, Athens, GA 30602, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-MAR-2015
            Assembly Method                   :: SPAdes v. MARCH-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 93.0x
            Sequencing Technology             :: Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003719335.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:42:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,967
            CDSs (total)                      :: 5,826
            Genes (coding)                    :: 5,778
            CDSs (with protein)               :: 5,778
            Genes (RNA)                       :: 141
            rRNAs                             :: 5, 10, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 10, 9 (16S, 23S)
            tRNAs                             :: 113
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 8 of 48
            Pseudo Genes (incomplete)         :: 39 of 48
            Pseudo Genes (internal stop)      :: 7 of 48
            Pseudo Genes (multiple problems)  :: 6 of 48
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:46:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 68632
            Orig. end                         :: 89505
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RIAS01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20873
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10873](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    956..971
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.71"
                     /tool="antismash"
     misc_feature    998..1013
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     misc_feature    complement(1389..1406)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.26"
                     /tool="antismash"
     gene            complement(2153..2284)
                     /locus_tag="EC604_RS30850"
     CDS             complement(2153..2284)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS30850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275670044.1"
                     /transl_table=11
                     /translation="MKKWLVRIGAYTGYSFLIALALFYLFFLAVIIMLAIYDFQGGT"
     misc_feature    2275..2288
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.93"
                     /tool="antismash"
     misc_feature    complement(2276..2289)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.1"
                     /tool="antismash"
     misc_feature    2276..2290
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.76"
                     /tool="antismash"
     misc_feature    complement(2277..2290)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.16"
                     /tool="antismash"
     gene            complement(2559..2873)
                     /locus_tag="EC604_RS16890"
                     /old_locus_tag="EC604_16790"
     CDS             complement(2559..2873)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822860.1"
                     /locus_tag="EC604_RS16890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16790"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_090922789.1"
                     /transl_table=11
                     /translation="MAWLAIVGAGICEIFGVIGINGASTRKGWPYIVLMLVSFVFSFSL
                     LSYAMTSIPMGTAYAVWTGIGTVGSTVTGMLLFGERKEAKRLLFIAMILVAAVGLKIIT
                     "
     gene            complement(2873..3229)
                     /locus_tag="EC604_RS16895"
                     /old_locus_tag="EC604_16795"
     CDS             complement(2873..3229)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691902.1"
                     /locus_tag="EC604_RS16895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16795"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_123065281.1"
                     /transl_table=11
                     /translation="MNRNWLYVFVGGIIEIVWVSGLKHASNAWEWALTGLAIFISFGLI
                     IAAAKRLPVGTVYAVFTGIGTAGTVLTEMLLFGEPFRLAKMLLIGLLLCGVIGLKLVTD
                     QQESQKPQVKGGAV"
     gene            complement(3235..3849)
                     /locus_tag="EC604_RS16900"
                     /old_locus_tag="EC604_16800"
     CDS             complement(3235..3849)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691903.1"
                     /locus_tag="EC604_RS16900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16800"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_123065282.1"
                     /transl_table=11
                     /translation="MTGYSIRDAALFHFARDGYEGASLRAIADEVGIKKPSIYAHFSCK
                     EDLFMHTLEYAFDEVRRHTLEYFRDHAHLPLEERLRGLLTWFEQEYQDHASARLMLRNC
                     YYPPPDLYSQVMDLVYPFLDGMERTLSRLLQRAIRGGDVPPIPAEQAAIAFMTFLDGIT
                     VEIIYGSSRRYKRRLDASWPVFWNGIHSLNEQARPIVTEGD"
     gene            complement(4077..5573)
                     /locus_tag="EC604_RS16905"
                     /old_locus_tag="EC604_16805"
     CDS             complement(4077..5573)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691904.1"
                     /locus_tag="EC604_RS16905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16805"
                     /product="phospholipase D family protein"
                     /protein_id="WP_240036972.1"
                     /transl_table=11
                     /translation="MFSLRRHTSNRKTSRSKFPYIRTALAVMILWLIAVMLYQTYKPLP
                     PGISYESPEYRVKNVQFLHDLTYPSADGQMQHEQQIFQRMLQVVEDAEQFVVVDMFLFN
                     NYQHKGQNFPPVSQEFTDALVGKKMQHPDMDIWFITDEVNTNYNSAPNPLLEQMKQANI
                     HVVVTNDAPLRDSTPVYSAVWRTFFQWFGQSGKGWIPNLMATDGPDVTVRSYLKLLNVK
                     ANHRKVVVSEKTAIVSSGNIHDPSAYHSNIGFEITGPIIGDILQSEQAVVDISGGGQLP
                     DYTETSKAFPSGKSSENDGPIRLRYVTEGKVNDALLDELSQVGKGDTLWMGMFYIASPK
                     VLEALLDASERGTDIRLVLDPNENAFGQEKIGIPNRPVAAELHDKSNGKIQIRWYNTTK
                     EQYHTKMMYIAKANGDHIVLGGSTNFTPRNLNDYNLENNVWIAAPADNKFTLDVANYFK
                     RIWTNEDAEFTLNLEEFQEKTTFLKGILYKLQLILGFTTF"
     gene            5778..6707
                     /locus_tag="EC604_RS16910"
                     /old_locus_tag="EC604_16810"
     CDS             5778..6707
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691905.1"
                     /locus_tag="EC604_RS16910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16810"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_123065283.1"
                     /transl_table=11
                     /translation="MYSIKQVVAMLGIQAVTLRAWENRYNAVTPERTESGYRMYTEENV
                     ADLRWLKEQIDQHQANISEAVRMLKISKAKRPESSSPAPMVPPVPVMEEAYAQMADQIY
                     DSLYHFQGERANGLIDFGFTMYGYDSMFYHVLVPILVRVGDAWEAGRATVAQEHFMTQL
                     ISQRFYQFFHLFPIYPHLPKVLALCPEGEHHQVGLLLFSLFMRKNGAEVLYLGANTPEE
                     GVFPILREQKIKLVCLSITSPELVEACDQLIGRIQDEFPHIRFVLGGKGFERAKHARYP
                     EWIMPEDSADWQSWIEREYFTDRPPGAG"
     misc_feature    6795..6804
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            6994..8544
                     /gene="crtI"
                     /locus_tag="EC604_RS16915"
                     /old_locus_tag="EC604_16815"
     CDS             6994..8544
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691906.1"
                     /locus_tag="EC604_RS16915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16815"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_123065284.1"
                     /transl_table=11
                     /translation="MIPNQQRKRAAVIGAGPGGLAAAMLLSGQGYEVDVYEKQPAIGGR
                     SSRLELGEYKFDRGATFLMMPQLIEEMFDVVGRKLSDYVDMKELTPLYALNFGDKVFTP
                     SRNREDTAAQIKELFPGNEENYLRYMRDEEVKFGKVMPLLRRPFGKLTDYLRKDAITAL
                     PKLDINNTVYGILSRYFTDERLRWAFTFQSKYLGMSAWDCPGTFTILSFIEHQYGLFHP
                     IGGVNRVFQAMADVVEENGGRIHTSTPVKQVIVRDGRAEGVLLESGERIEADHVVVNAD
                     FAHAVNHLFEPGVLKKYTPEKMKRKKYSCSTAMLYLGVDGEIDLPHHSIYFPEDYRVNV
                     DEITKHKILSADPSLYVHNPSRLDPTLAPAGKSALYVLMPTPNLTGDIDWEAERAKVQE
                     AMLKRLEAIPELADIRGRIEECMMFTPLDWQNELDVYQGATFNMAHNLGQMMYLRPHNQ
                     FEELEHAWLVGGGTHPGSGLPTIFESARISVRLIQEEDARRRTKPSSYVKTAEAGGHS"
     gene            8541..10004
                     /gene="crtI"
                     /locus_tag="EC604_RS16920"
                     /old_locus_tag="EC604_16820"
     CDS             8541..10004
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691907.1"
                     /locus_tag="EC604_RS16920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16820"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_123065285.1"
                     /transl_table=11
                     /translation="MKRAAVVGAGIGGLTSALLLNRQGWDVTVYERGSRVGGRIAFEQE
                     GDYRIDQGPTIVLLPEMLLGILEEAGVDRSKVELLRCDPLYRVHYHSGRVMTKKTDRSE
                     QMAEIERLFPGEGSGFTRFMKDMDTLFPAGRAAFLEQMFPRKRDFFTPSLMSLMGKLRA
                     HKSVRKAVGDYFEHEELLDAYSLQSLYIGGSPFGTPGIYSLLPYAEHEYGIWMVKGGYA
                     ALPAILEQELLSRGGKIKLNTEVTGLKISNGVCEGIKMADGAEKVDAVIYNGDFPNLNG
                     LLKQVPEIPVKRKPYRPSSGCVLIYAGADKRWEEATTHQFFLPPSLDGSLRQVFNERRI
                     PAKPSFYVFNPAAVDETAAPPGQSVLYFLIPVPDAEGVNWEHESEALAERVLEEAERRG
                     FPGLRAALQWKKVRTPADAARDGLYGGGSFGIAPVLFQSGVYRPQPKPFPKIQGLYAAG
                     ASVHPGGGVPIVMQGARMAVNQLMKEMGK"
     gene            10001..10873
                     /locus_tag="EC604_RS16925"
                     /old_locus_tag="EC604_16825"
     CDS             10001..10873
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691908.1"
                     /locus_tag="EC604_RS16925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16825"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_123065286.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.1e-49, bitscore:
                     162.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 5.6e-69,
                     bitscore: 226.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEAILSRCEELMQKGSSSFYQAFKGLPSPRREAVYVIYAFCRMI
                     DDSVDEPEQSTYTIHEIRDLFEHLEEAEGHFIWPALRWLFGSFPHLDKGPFFRQMEGQL
                     TDLEVTHYTTLEQLEHYCYLVAGTVGEMLLPVLRNDNGAEVAMNGIALGKGMQIVNIIR
                     DVGEDRARMRRYVPLEIMERHGYSEQDWEDGIVDDRFIAIIQDLKAAALNWFRIGMDRL
                     DTYPVESAFSIELAAAFYSTILHVVERNDYDVYTKRAYVSDELKLEMLGAIVKRYPMLA
                     YQASRMAVS"
     gene            10873..11640
                     /locus_tag="EC604_RS16930"
                     /old_locus_tag="EC604_16830"
     CDS             10873..11640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691909.1"
                     /locus_tag="EC604_RS16930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16830"
                     /product="carotenoid biosynthesis protein"
                     /protein_id="WP_123065287.1"
                     /transl_table=11
                     /translation="MVQWVYWVWYAIGAILMLTIGVPEALSFSNGLFLVFYSLYVLDLI
                     YQQHRRSDLSDQSVKWLRPGLWISSFIIWLGGMGVEWIGVHTHWPFGEYAYSDFFGIHL
                     FSVPVTLGFAWIAVVGNSALISGGGSTWGGKLVRAIKTGFWAIVLDFVLDPVAHARGFW
                     EWQAPGGFYGVPWTNYISWFIMGAFLSLFLPAMPKDRRSLLRAKWLYQLFILLFGLLAL
                     KEGITGSFIIAIAGVLLAEGSWLYDSRRKVQSV"
     gene            11609..12382
                     /locus_tag="EC604_RS16935"
                     /old_locus_tag="EC604_16835"
     CDS             11609..12382
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691910.1"
                     /locus_tag="EC604_RS16935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16835"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_123065288.1"
                     /transl_table=11
                     /translation="MIRAVKSKAFDRVFSLYNHYYLLHRRFRSFTLSGSLDPQMMDGNG
                     MGGMEPMAPEQPVVYFMNHSSWWDGLLLYHAAKQTSRGDHYVMMEERQLRQYAFFRKLG
                     AYSINKNSASGVRTSLQYTNELLAAGKRVWIFPQGEIIHQEARPIQFRPGIGLVLRRFP
                     QAIAVPVTLCHGMVQHDLPEISMKAGPPIVEDWNVWKSEEIAERLGHVLEQQLNDHRAT
                     LIRLGQGSLPDARSLIRGTRSTSEKYDEARKRVNR"
     gene            12384..13544
                     /locus_tag="EC604_RS16940"
                     /old_locus_tag="EC604_16840"
     CDS             12384..13544
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691911.1"
                     /locus_tag="EC604_RS16940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16840"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_240036974.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.7e-25,
                     bitscore: 81.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNESMNASEILWMCLVGGLLLQLLFAVWNASCLPKVRSFRKGNIV
                     PPDQLVSVLIPARNERIHIEECLHSVLASQTNGFRMEVLVLDDRSEDETAALVQAMADR
                     DSRVRLLRGTELPAGWMGKSHACNRLVQEAQGDWFMFVDADVRVKPDAIRHTLAAGCAQ
                     GGGLVTGFPYQVAKTWMEKLVVPMMMFTIISHLPIFMIRRSASPMFVAATGAFLLIHRT
                     SYEASGGHAAIQGHLVDDMSLAKAVKRAGHPVMLADVHDVTSTRMYQNGAEVWNGYKKN
                     MYEGMGRKDVLLLGTMLMYFVMYIVPPLGLVIGLLTGSETSFLYGFIGMLLGMAVKRVS
                     DHIGGQPWWLALLQPISMACVIAIGLASWQAGRSGKGYVWKGRRYS"
     gene            13670..15190
                     /gene="crtI"
                     /locus_tag="EC604_RS16945"
                     /old_locus_tag="EC604_16845"
     CDS             13670..15190
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691912.1"
                     /locus_tag="EC604_RS16945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16845"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_123065430.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.3e-09, bitscore:
                     29.0, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 5.7e-11, bitscore: 36.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTWHQGEASSGNLKQDVIIIGAGFGGLSCAIRLATAGLRVTILE
                     RQAHVGGKLQQIQQDGYHFDRGPSTITMPDAFRSVFDQAGVVMENYVQLYELEPRTRNV
                     FADGTVVDLSRNRGWMKEQIAVYSPEDALRYDAFMDESAALYAEANRHFLGKLLLNPSD
                     KYKFQMLRSLLRVRPTVRLDNLLRKYFSHPHTLAMFGRYATYVGSSPYLSPSIFAMMGH
                     VEAEVGVYGVKGGTYQLIEGMTRLAQEKGVQIMTGVEVHQIAVRHGKVVGMDTDRGFME
                     AKQVVANGDVLSVNRLLLAPEHRKRMSDARIAKYEPSISGFVTLAGVRRKYDQLLHHTV
                     FFPEQYKPEFDDIFRDRRMPSDPTIYICYSGYSEAGMAPEGASNLFILVNAPYLSQAWN
                     WEEQKYRYGEFVLEQLEARGIGGLKQSEVLIFYTPQHIERDTLAHQGSIYGISSNSVKQ
                     TFMRPGNQSKDVQGLWYVGGTTHPGGGTPIVTLSGQLVGEQLAAELGR"
     gene            15731..16798
                     /gene="fni"
                     /locus_tag="EC604_RS16950"
                     /old_locus_tag="EC604_16850"
     CDS             15731..16798
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fni"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691913.1"
                     /locus_tag="EC604_RS16950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16850"
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_123065289.1"
                     /transl_table=11
                     /translation="MNEQERAGKRLLPEVATGERKLEHVRLCLEENVAGEGITSGLEKY
                     AFRHHPLPELDFEEVHLDTSFLGKKMRTPLLISSMTGGSKTTGAINERLARVANARGWA
                     LGVGSIRAAVEQPELASTFDVRRWAPDIPVIANLGAVQLNYGFSTADFQRAVDIAGADL
                     LVLHLNTLQEVFQPEGNTNFSGLYQRIEKLCRELEVPVGVKEVGFGIDGVTAQRLYEAG
                     VAFIDVAGAGGTSWVQVEKYRNNNPVRRAAAEAFADWGIPTAECIQDVRALNPDGAMIG
                     SGGLYTGVDAAKALALGADLAGFGRSLLESAVTSDEALSERLEQVEFELRTVMFGIGAG
                     SVADVKRTERLVERR"
     misc_feature    complement(16956..16971)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.91"
                     /tool="antismash"
     misc_feature    17191..17208
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            17255..18568
                     /locus_tag="EC604_RS16955"
                     /old_locus_tag="EC604_16855"
     CDS             17255..18568
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691549.1"
                     /locus_tag="EC604_RS16955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16855"
                     /product="transcriptional regulator"
                     /protein_id="WP_240036976.1"
                     /transl_table=11
                     /translation="MTINRFSEISGVNSGTLSGTLKGNRPIGLNQLDRITAGIGMPEGE
                     LYELYINEYLVDSNLDWRRLRPFLYRCAELGHITHMETAVNYVMDNLSYIPMLFELAEQ
                     LHSEGKMEACKPLYRCVAESEKLQHSERLALCQYRLFSIGLSNDQVHNLTLATRFELFV
                     ERLDEQYQFDALNELINVYASLRRWDKVKEFADQLQIKAFIQYDAKKTLREVETKTKKK
                     IVYYALYSYLALAEVSYQHGKYEETLQYVSKYADYSWIKDPTEEEKMVILQFQDWSEGN
                     NYYFRLLSGETELIPEYLTYISDRKKEIFPALCAIVTAANRYNVNIDDVLEQYQSHLDY
                     EEQSSCFGKMSKQYTNDQYGILLAGLGTYYLRNNHYDRGVAYIRQGMEFAIENMNKDGL
                     LDCLGLFDDLQYVVTGLGVKPSAELLIEKIQRLYSPER"
     gene            18837..19007
                     /locus_tag="EC604_RS16960"
                     /old_locus_tag="EC604_16860"
     CDS             18837..19007
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279746.1"
                     /locus_tag="EC604_RS16960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16860"
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="WP_123065291.1"
                     /transl_table=11
                     /translation="MERDELKLRIEEARERLHQLKTEYGELLHPQVIRQSMVLDELINM
                     YNHVKRIKPME"
     gene            complement(19096..19557)
                     /locus_tag="EC604_RS16965"
                     /old_locus_tag="EC604_16865"
     CDS             complement(19096..19557)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS16965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_16865"
                     /product="hypothetical protein"
                     /protein_id="WP_123065292.1"
                     /transl_table=11
                     /translation="MHTKPRRPFSKIKIMIALGLFLALGTIVVMSFLNAIDPFRKLRIT
                     IDNQSDYDIIQIKTGITNWKQPILDSSTADKKEDSDLLYTFSEEIVSGKKIKYTPKLHF
                     LGESSVYVIFKDSRGNTYTKTACGYTESVSGTSLITITNDNVTVKENCT"
     gene            19916..20386
                     /locus_tag="EC604_RS16970"
                     /old_locus_tag="EC604_16870"
     CDS             19916..20386
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017691916.1"
                     /locus_tag="EC604_RS16970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_16870"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_123065293.1"
                     /transl_table=11
                     /translation="MELSPMNTEQFASFRSRSIEDFAQEKVEAGTWAPEEALGQAEESY
                     ERYLPEGLDTPGAYVFNLVHPVDGIVGYIWFNITENRRGKEAFLLDIVVEEAYRGKGYG
                     TETMNALEKTARSLGVNRIGLHVFGHNERASSLYRKMGYEVTDLTMYKEIKG"
     misc_feature    20854..20868
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
ORIGIN
        1 tatacatggt atccataatg tgctggagct cggagtgcat cggctcaagg atagttatcc
       61 cttccaggtt gcgcatcata ccgagaatga tggcacgcct tggcataaat tccatgatct
      121 cttgccttag tatggctatg gtctcaagca catcattttt tgattgaccg ctgggcaggt
      181 cgcttgatgc gatatcttgc atctgtttca gaatatggac gggatgccgc aacatggctg
      241 catccggttg gggctcagca atccaggcag gccactgatc cagagaaatc agaggttctg
      301 gccgatgctg gaggcagccc tgtgctgcat aatccatcat ctgtaaaaga tgtgtagcca
      361 tcttattgac cgtaagggaa ggcatttcgg taaaccagat tttgacgtac gacaggaaaa
      421 gtccatgtgt cagcaggata agatcaatcg tataaggctc gatctcggag ccgtacagat
      481 cttccagttt acttttgaac caatgcaacg tacgtatctc aatatctctt tgctgagggg
      541 tgcagtgctc cttgcgctgt tgttcatcat ccatcatcat gctgcgtagc tggacacgta
      601 aaaattcctt caattccgcg acatgcgtta gcagcacctc aatctgttta tgtagccgtt
      661 ctctggaagt caggctgctt tcatgttcaa tctgggacat ctcatccata agaatgtata
      721 cacagtactc cagcgtactg gcctccagtt cctctttgga tttgaacatc agatataagc
      781 tgcctttaga catcccgcat aattcggcaa tctcctgcat ggaggttgcg gcgctgccct
      841 tggccgaaaa cagcttgagt gctgtggtga taaccagttt tcttttttca ttcatcccat
      901 ggatcgggtt cattaagggt atgttcacct cgctgggaac tcttgagttc ttatattgac
      961 tttgtggtca aactaagtat aaacgatgtg tatggaggat tacaaatgtg cacgatatag
     1021 ggggagagag tcgaaaagta gattcagaga agaaccgaga atagaactca gaaagaattg
     1081 ctaaagaatt gctaaaaaac tgagaaaaga attgagataa gacatctaga aaagaactga
     1141 gataagaatt gagaaaataa agtacattat acaagataca agccgtaaac ttatacgttg
     1201 cacttttggg agatggggat ggaagaatgc ataaagggcg catcgaagac gcataaagga
     1261 agcatcgaaa acgcatcaag aaggattcaa gtatgcaggc ctggccgcac ggctgatcat
     1321 cttgatgcgc caaactcatt acatcacgtg ccaggagatg cgtactgtgc aaacacaacg
     1381 aaaacacatc aacacatcaa taacatcaac acattaagaa catcaataac atcaataaca
     1441 tcaagaacgt taagaacaca ttaagaaagc ttcaagggcg actcaagaac atatcgaaaa
     1501 tttattctaa cgatcacggc agagcttatt tgagcaatat acatcctttt gaaattctaa
     1561 cgatcaccag aaaccttaat ttgcagaaaa cacaagttaa acgtgcactt tcgcatcaaa
     1621 atccttaaat aagctctcct gtgatcgtta gaaatataaa acttgtaatt tggcccaaat
     1681 agcgttactg gtgatcgtta gaattaaaat gcatgcaccg cgctacttcg gaaaggaaag
     1741 gaaaggaaaa gagagaacaa acgaaggaat atcgaatgaa gggaagtaag ccaagcaaaa
     1801 cagaaaaaca agaaagggta agtaaagtaa agtaaagtaa agtaaagtaa agtgaagaag
     1861 tgaagtgaag tatagaagta aagaaaagaa gaaaagaaga aaagaaaaga agaaaaggaa
     1921 gtggggcgaa agcgaaggag agcgcaaaca gaaagaaatg aaagtaaacc aatgtaatta
     1981 aaatagatta gagtaattaa agaagatata gaaagaagat atagtacagt ctcaataaaa
     2041 gaaattaaaa aataaaaaag gaataaatga aaatccaagc aaagcattgc gagtctaagc
     2101 aaaaagagca agtaaacgga agagaagatg aaaggaaaga cagagaagca gactatgttc
     2161 ctccctggaa atcgtatata gcgagcatga taatcactgc caggaagaag agatagaaga
     2221 gtgccagtgc gatcaggaac gaataaccgg tatatgcgcc gatacgtacc aaccattttt
     2281 tcataaaaat taccctcctt cattcccatc agcttaatgg caagactatt ttttatatta
     2341 cattataccc caaattacct gttgtactta aaacatttcg cccaaaattt gtacctgcat
     2401 aaaagaacct aaacaaacct atctccacaa acctatctcc ataaatgtat ctacacaatc
     2461 gcacttaagc aatcgtacac aaaaaagacg actccctgaa tgaagtcgcc tttcttagtg
     2521 ttaaattaca tccattatgt tgaatggtat tcattacatt acgtaatgat tttcaatcct
     2581 actgctgcta ccaaaatcat tgcaatgaac agcagccgct tcgcttcttt ccgttcacca
     2641 aatagaagca tgcccgtcac cgtacttcct actgtaccaa ttcctgtcca taccgcgtag
     2701 gctgtgccca tagggataga tgtcatagcg taagataaca gcgagaagct gaatacaaac
     2761 gataccagca tcaggacaat gtaaggccaa cccttacgcg tagaagctcc attgatgccg
     2821 atgactccaa atatttcaca tatcccagca cctactatag caagccaagc catcagacgg
     2881 cacctccttt aacttggggt ttctggcttt cctgctgatc ggtgaccagc ttcagtccga
     2941 tgacgccaca gagcaacagt ccaatcagca gcattttagc cagacggaac ggctcgccga
     3001 acagcagcat ttcggtcaac accgtaccag ctgtgccgat cccggtaaac acggcataga
     3061 ccgtacccac gggcagtctt ttggcagcag caataatcag gccaaagctg ataaatatgg
     3121 cgagtcccgt caatgcccat tcccaagcat tcgaggcatg tttaagtccg ctaacccaga
     3181 caatttcaat gatgcctcct acaaaaacgt ataaccagtt gcggttcatg atgttcaatc
     3241 tccttctgtc acaatagggc gtgcctgttc attcaagctg tgtataccat tccaaaagac
     3301 gggccaggac gcatccagcc gtctcttgta ccgacgtgag cttccataga taatttcaac
     3361 cgtaatgcca tcgagaaagg tcataaaagc aatggcggcc tgctcggcag gaataggtgg
     3421 aacatccccc ccgcgaatcg ctcgctgcaa cagccgagac aatgtacgct ccatgccgtc
     3481 cagaaatgga tacaccagat ccatcacctg gctgtacaga tcgggaggtg gataataaca
     3541 attgcgcaac atcaacctgg cagaggcatg atcctgatac tcctgctcga accacgtgag
     3601 caaccctcgc aaccgttctt ccagtggcag gtgggcgtgg tcgcggaaat actccaaggt
     3661 atgtcgccgc acttcgtcaa atgcatactc aagcgtgtgc ataaacaagt cttctttaca
     3721 actgaaatgc gcatatatag agggtttctt aatccccact tcatcagcta tcgctcttag
     3781 cgaagcccct tcataaccgt ctctagcaaa atgaaacagg gccgcatccc ggatagaata
     3841 accagtcatt atattcacct tcctaacggt cgttaggtaa catcttttca cacattacat
     3901 cctctgtcaa gacagaacag caatcacaaa atacacccgc cgcacataaa gattacagac
     3961 ggatgcattt agttaaatgg atgtatgggt taagttgtga tctggagtca ctgtataggc
     4021 tgaacgaatc atttaccaaa aacgggcctt cattcaagcg gaaataaata cgtcaattag
     4081 aatgttgtaa acccaagaat gagctgcagt ttatacagaa tgcctttcaa gaaggtggtc
     4141 ttctcctgga attcttccag attcagagtg aattcagcat cctcgtttgt ccaaatgcgc
     4201 ttgaaataat tcgcaacgtc taacgtaaac ttgttgtctg ccggagctgc aatccacaca
     4261 ttgttctcta gattgtagtc attcagattc cggggagtga agttggttga tccaccgagc
     4321 acgatatgat ctccgttagc cttcgcgata tacatcattt tggtatggta ttgctctttg
     4381 gtcgtgttgt accaacgaat ctggattttg ccgttcgatt tatcatgtaa ttcggctgct
     4441 acgggacgat tgggaatgcc gattttctcc tgaccaaagg cattttcatt aggatcgagc
     4501 acaagccgaa tgtccgttcc tcgctctgag gcatccagca atgcttccag tactttcggt
     4561 gaagcgatat agaacattcc catccatagg gtatcccctt tcccgacctg gcttaactca
     4621 tcgagcaagg catcattgac tttgccttcg gtcacataac gaaggcgaat aggcccatca
     4681 ttttcactcg atttcccgga tgggaaggcc ttggaagttt cggtatagtc ggggagttga
     4741 cctcctccgg atatgtccac aacagcttgc tccgattgaa ggatatcccc aataatcggg
     4801 ccagtaatct caaatccaat attggagtga tatgcacttg gatcatgaat gttgcctgat
     4861 gacacgatag cggttttttc gctgacaaca accttgcggt gatttgcctt cacattgagt
     4921 aatttcaggt aagatctcac cgtaacatcc gggccatcgg tcgccatcag gttaggaatc
     4981 caacctttcc ctgactgacc gaaccattgg aaaaacgtac gccagaccgc agaatacacc
     5041 ggtgtagaat ccctcagtgg agcatcattc gtgacgacga catgaatgtt agcctgtttc
     5101 atctgttcca gcagcggatt gggggccgag ttatagttgg tgttcacctc atcggtaatg
     5161 aaccagatgt ccatgtcggg atgctgcatt tttttgccta cgagtgcatc cgtaaactcc
     5221 tgactgacag gtggaaagtt ctgtcccttg tgctggtagt tgttgaacag aaacatatct
     5281 acaacgacaa actgctcggc atcctcaact acctgaagca tccgctggaa aatctgctgt
     5341 tcatgctgca tctgtccatc ggcagatgga tacgtgagat catgcagaaa ctgcacgttt
     5401 ttcacccggt attccgggct ctcataggag atccctggcg gcaggggttt ataggtctga
     5461 tagagcataa cagcaataag ccaaaggatc attactgcca atgctgtacg tatgtatggg
     5521 aatttgctgc gagaagtttt gcggttagag gtatgacggc gtaatgagaa caaggctgga
     5581 ctcccccttt ctatctgtct atgcttgctg acgtttatta ccacaggtgc cgcgatgttg
     5641 acgcaggagc ccttgaagga tgtttatgac aagctggttc cacaatttgg gcgtgttcat
     5701 cgacaggtgc aaggccgttg tgtataatga acgtattatt tttgtagaac gtttatggag
     5761 agaaagtagg taatcacgtg tattccatca aacaagtcgt tgccatgctg ggcattcagg
     5821 cggtcacgct ccgggcttgg gaaaatcggt ataatgcagt cacccctgag cggacagagt
     5881 cgggttatcg catgtatacg gaagagaatg tggcggatct gcgttggctg aaggagcaga
     5941 ttgatcagca tcaggccaat atttccgagg ccgtacgcat gttgaagatt agtaaagcca
     6001 aacggcccga gtcttcttca cctgcgccga tggtgccccc ggtacccgtg atggaagagg
     6061 cttatgcaca gatggctgat cagatctatg actccctcta tcattttcag ggcgagcgtg
     6121 ccaacggttt gattgatttt ggtttcacga tgtacggata tgacagcatg ttctaccatg
     6181 tgcttgttcc aatcttggtt cgggtcggag acgcatggga agcaggacgt gcaacggtag
     6241 cgcaggagca tttcatgact caattgatct cccagcgctt ttatcagttt ttccatctgt
     6301 tcccgatcta tccgcatcta cccaaagtac ttgctctctg tccggaaggg gagcatcatc
     6361 aggttggttt attgttgttc tctttattta tgcgcaaaaa tggagcggaa gtcctgtatc
     6421 tcggagccaa tacaccggaa gaaggggtat ttccaattct ccgtgagcag aaaatcaaac
     6481 tggtttgcct atcgatcacg agccctgagc ttgtagaagc ctgtgaccag ttgattgggc
     6541 ggattcagga cgagtttcct catatccgtt ttgtgctggg cggcaaaggg tttgaacgtg
     6601 cgaagcatgc tcgttaccca gagtggatta tgcctgaaga ttcggcagac tggcagtctt
     6661 ggattgaacg ggaatatttt acggatcgcc caccaggtgc gggataatga ttgtatagca
     6721 atcacacata aagcagataa tgcgggaata gattcataac atagcggaca tcctttgatc
     6781 caatgatcaa gggatgtttt tttatatatc catacataga aaagatgatt aatttgaccc
     6841 gtgggtcatt ttatgtttta cttgtcgtat aatatttgta caccatttgt ataatgtttt
     6901 ttagtttacc cgcttgaagt gtttcaatgc ggtttaataa taggttaggg gcttaagaac
     6961 tagagatatt ccctacatag aaaggtgagt ggcatgatac cgaatcaaca acgcaaacgt
     7021 gcagctgtca ttggcgcagg cccgggtgga ctcgcggcag ccatgttact gtccggtcag
     7081 ggatacgagg tcgatgtata cgagaaacag ccagccattg gcggacgatc ttcccgtctg
     7141 gagcttggtg aatacaagtt tgaccgcggg gctacctttt tgatgatgcc tcagttgatt
     7201 gaagagatgt ttgatgtggt cggacgcaag ctgtcggatt atgtagatat gaaagaactg
     7261 accccgctgt acgctttgaa ctttggagat aaggtgttca cgccttcacg caatcgggag
     7321 gatacagcag cgcagatcaa agagctgttc cccggcaatg aagagaatta cctccggtac
     7381 atgcgggacg aagaagtaaa gtttggcaaa gtgatgccac tgctccgccg tccgtttggc
     7441 aagctcaccg attatttacg taaagatgcg attacggctc tacctaaact tgatataaat
     7501 aatacggttt acggcattct ttcccggtac tttaccgacg aacgcctgcg ttgggccttt
     7561 acattccagt ccaaatattt ggggatgtcc gcatgggatt gtccgggaac atttacgata
     7621 ttgtcgttta tcgaacacca atatggactg ttccatccga tcggcggcgt gaatcgggta
     7681 ttccaggcga tggccgatgt cgttgaggag aatggcggac gtattcacac gagtacacct
     7741 gtgaagcagg ttattgttcg tgatggtcgc gccgagggtg tactgcttga aagcggagaa
     7801 cggatcgaag ccgatcatgt cgtagtcaat gccgattttg cccatgcagt gaaccatttg
     7861 ttcgaacctg gcgtactgaa gaagtacaca cctgagaaaa tgaaacgcaa aaagtattcc
     7921 tgttctacag cgatgttgta tctaggcgta gacggcgaga ttgatctgcc gcatcactcc
     7981 atctattttc cagaagatta ccgggtgaat gtggatgaga ttacgaagca caaaatatta
     8041 tccgctgatc cgtctctata tgttcataac ccatccagac tcgatccgac actcgcacca
     8101 gcaggaaaat ctgcacttta tgtactgatg ccgacaccaa accttacagg agacatcgac
     8161 tgggaggctg aacgagcgaa ggtacaggaa gcgatgttga agcgtcttga agcgatccct
     8221 gagctggcag acatccgtgg gcggattgaa gaatgcatga tgtttacacc gctggattgg
     8281 caaaatgagc tggatgtata ccagggagca acgtttaata tggcacataa cctgggtcag
     8341 atgatgtatc tcagaccgca caatcagttc gaggaattgg agcatgcctg gctggttggt
     8401 ggaggaacgc atccaggcag cggtttaccg actatttttg aatccgcacg aatcagcgtg
     8461 agactcattc aggaagagga tgcgcgaaga cgtacgaaac catcctctta tgtgaaaaca
     8521 gcggaagctg gaggccactc atgaaacgag ctgctgttgt aggtgcaggg attgggggac
     8581 tgacctcagc tctgctgctg aaccgtcagg gatgggatgt tacggtatac gagcggggct
     8641 cccgcgtagg tggacggatt gcttttgaac aggaaggcga ttaccggatt gatcaggggc
     8701 cgaccattgt cttgctgccc gagatgttgc ttggcattct ggaagaggct ggtgtggatc
     8761 gctccaaagt cgagctgctg cgctgtgacc cgttataccg ggtgcactat cacagcggac
     8821 gtgtcatgac caagaagaca gaccggagtg agcagatggc cgagattgaa aggttattcc
     8881 cgggagaagg cagtggattc acaagattca tgaaggatat ggacacgttg tttcccgcag
     8941 gccgagcggc gtttctggaa cagatgtttc cgcgcaaaag ggacttcttc accccttcgc
     9001 tcatgtcgct tatgggcaag ctgcgtgcac acaagagtgt gcggaaggct gtaggggatt
     9061 actttgaaca tgaagaattg ctggatgcct attcgctgca aagcttgtat atcggtgggt
     9121 cgccctttgg cacgccgggc atttattcat tgcttcctta cgccgagcac gagtatggca
     9181 tctggatggt gaagggcgga tatgcggctc tgcccgctat tctggagcag gaactgctct
     9241 ctcgcggcgg caagatcaag ctgaatacag aagttactgg attgaagata agtaatggag
     9301 tgtgcgaagg gattaaaatg gctgacggtg ctgaaaaggt ggatgccgtg atctataacg
     9361 gggattttcc gaacttgaat gggctactga agcaggtgcc ggaaataccc gtgaaacgca
     9421 agccctatcg cccttcatcg gggtgcgtgc tgatctatgc cggagcagac aaaaggtggg
     9481 aggaggccac aacgcatcag tttttcctgc caccaagcct agatggtagt ttacgccaag
     9541 tgttcaacga gcgccgtatt ccggcgaagc catcatttta cgtattcaac ccggctgcgg
     9601 tggacgagac agctgcacct ccgggacaga gtgtactgta tttcctcatt ccggtaccgg
     9661 atgcagaagg cgtgaactgg gaacacgaga gtgaggcgct ggcagaacgt gtgctggaag
     9721 aggcggagcg gcggggattc ccgggtttac gtgcagcgct gcaatggaaa aaggtacgta
     9781 cacctgctga cgccgcgcgt gatggtcttt atggtggagg aagctttggc attgctcctg
     9841 tcctgtttca gtcaggagta tatcgcccgc agcccaagcc gtttccgaag atacaaggct
     9901 tgtacgctgc cggggcttcg gtacatccag gaggcggcgt gcctattgtg atgcagggcg
     9961 ctaggatggc tgtcaatcaa ctcatgaagg agatggggaa atgaacgaag caattttgag
    10021 caggtgtgaa gagttgatgc agaagggttc ctcgtctttt tatcaggcat ttaagggcct
    10081 gccgagtccc cgccgcgaag cggtatatgt catctatgcg ttttgccgca tgattgacga
    10141 tagtgtggat gagccggagc aatcgacata tacgattcat gagattcgtg atttatttga
    10201 acatctcgaa gaagccgagg gacattttat ctggccggca ctgagatggc tgttcggcag
    10261 ttttccccat ctggacaaag gtccgttttt tcgtcagatg gagggacaat taaccgatct
    10321 ggaagtgacc cactatacaa cactggaaca gctggaacac tattgttatc tggttgccgg
    10381 aactgttggt gagatgttgc tgcctgtgct gcgtaatgat aacggcgcag aagtggcgat
    10441 gaacggcatt gcgctgggca aaggcatgca gattgtgaac attattcgag acgtaggaga
    10501 agaccgggcc agaatgcgcc gctatgtacc gctggagatc atggagagac acggttactc
    10561 cgaacaggac tgggaagacg gtattgtgga tgaccgattt attgctatca ttcaggattt
    10621 gaaagctgca gcgcttaact ggttcaggat cggcatggat cgtctggaca cctatccggt
    10681 tgagagtgcc ttttcgattg agttagccgc ggccttctat tcaactatcc tgcacgtcgt
    10741 ggagcgtaac gactacgatg tgtacacgaa acgagcgtat gtcagcgatg aattgaaact
    10801 ggagatgctg ggtgcgattg tgaaacgtta tccgatgctg gcgtatcaag cttcccgaat
    10861 ggcggtatcc tgatggttca gtgggtgtac tgggtatggt acgccattgg tgctatccta
    10921 atgcttacaa ttggtgtgcc tgaggcgtta tccttctcta atgggctatt tctagtgttc
    10981 tactcgttgt atgtgcttga ccttatatat cagcaacatc gccgatctga cctgtccgac
    11041 cagtcagtca agtggctacg gcccggcctc tggatatcgt cctttatcat ctggctgggc
    11101 ggtatgggtg tggaatggat cggtgtacat acacactggc cttttggcga gtatgcctat
    11161 tccgacttct ttggcatcca tctgttcagt gtaccggtaa cacttggatt cgcctggatc
    11221 gcagtcgttg gcaactcggc gctgattagc ggcggtggat cgacttgggg tggtaagttg
    11281 gtacgggcaa tcaagacggg attttgggca attgtgctcg atttcgtgct tgaccctgtc
    11341 gctcatgcaa ggggattctg ggaatggcaa gcaccgggcg gattctacgg tgtcccgtgg
    11401 acaaactaca tcagttggtt cattatgggt gcatttctgt ctctcttttt gccggccatg
    11461 ccgaaggatc gacgttccct gctacgggca aaatggctgt accagctgtt tatccttctg
    11521 ttcggcctgc ttgcattaaa agaaggtata acaggcagct tcatcattgc catcgcaggt
    11581 gtactgcttg ccgaggggag ctggctgtat gattcgcgcc gtaaagtcca aagcgtttga
    11641 ccgggtgttc tcgctgtaca accattatta tctgctgcac agacgctttc gttcgttcac
    11701 gctctcgggt tctcttgacc cgcagatgat ggatggcaac ggcatgggcg ggatggagcc
    11761 tatggcgccg gaacagcccg ttgtctattt catgaaccat agctcgtggt gggatggtct
    11821 gttgctgtat catgcggcga agcaaacttc acgcggtgat cattatgtga tgatggagga
    11881 gcggcagctt cggcagtatg ctttttttcg caaactcgga gcgtattcaa tcaacaagaa
    11941 cagtgcatct ggtgttcgga catcgttgca atatacgaat gagttgctgg ctgctggcaa
    12001 aagggtctgg atattcccgc agggtgaaat tatacatcag gaggctcggc cgattcagtt
    12061 ccgtccgggc attggactcg tgcttcgtcg ttttccgcag gctattgccg tgccggtcac
    12121 cttatgtcat ggcatggttc agcatgacct gcctgaaatc tcaatgaagg ctggcccgcc
    12181 gatcgtggaa gattggaacg tgtggaagag cgaagagatt gcagagcggc tgggacatgt
    12241 gctggagcaa caactgaatg atcatagagc aacgttgatt cgacttggac aaggaagtct
    12301 gccagatgca aggtcattga ttcggggcac gcgttccact agcgaaaaat atgatgaggc
    12361 acgaaagcgg gtgaaccgat aacatgaatg agagtatgaa tgcatctgag atattgtgga
    12421 tgtgtctggt gggagggttg ctgctgcaac tgctctttgc ggtgtggaat gcctcttgcc
    12481 ttcccaaagt acgatcattc cgtaagggga acatcgtgcc gcccgatcag cttgtttcgg
    12541 tattgattcc cgcgcgaaat gaacgaatac atattgaaga atgtttgcac agtgtgcttg
    12601 ccagccaaac gaatgggttc cgcatggagg tacttgtact ggacgaccgc tccgaagatg
    12661 aaactgccgc tttggttcag gcgatggctg atcgagattc acgtgtacgt ttgctgcgtg
    12721 gtacggagct gcctgcgggt tggatgggta aatcccatgc ctgtaaccga ttggttcagg
    12781 aagcgcaagg agactggttt atgttcgtgg atgcagacgt ccgggtcaag ccggatgcca
    12841 ttcggcatac acttgctgcc gggtgtgcgc agggcggcgg gctggttacc ggcttcccgt
    12901 atcaggttgc gaagacctgg atggaaaagc ttgtcgtgcc gatgatgatg tttacgatca
    12961 tcagtcattt gcctattttc atgatacgca ggtcagccag tccaatgttt gtcgccgcta
    13021 cgggggcttt tttgcttatt catcgaacaa gttatgaagc atccggcggt catgcagcga
    13081 ttcaagggca tctggtggat gacatgagtc tcgccaaagc ggtgaaacgt gcgggtcatc
    13141 ccgtcatgct tgcagatgtc cacgatgtga cgagtacacg aatgtatcag aacggtgcag
    13201 aggtatggaa cggatataag aaaaatatgt atgaaggcat gggacgcaaa gacgtgctgt
    13261 tgctgggtac gatgctaatg tattttgtta tgtatatcgt gccgccactg ggtctggtta
    13321 tagggctatt aacgggcagc gaaacgtcat ttctgtatgg tttcataggc atgttgcttg
    13381 gcatggctgt aaaacgggta tccgatcata tcggaggtca gccgtggtgg cttgctcttt
    13441 tgcaaccaat cagtatggct tgtgtgattg ctattggtct agcctcatgg caggcaggtc
    13501 gatctggtaa agggtacgta tggaaaggca ggcggtatag ctgatgcaga gtgtacaagg
    13561 aaatggtgac ggttcggaag gtgcagggaa aggcaaaggt acagagacag gtcgaggtat
    13621 cacgggaggt agtacaggga cggggacaac gctggaaaaa ggaacggaaa tgcacacctg
    13681 gcaccaaggg gaagcttcaa gtggaaactt aaaacaggat gtcattataa tcggggcagg
    13741 cttcggaggt ctttcctgtg cgattcgcct tgctacggct ggcttgcggg taacgattct
    13801 ggagcgccag gcgcatgtgg gcggcaagct gcagcagatc cagcaggacg gttatcattt
    13861 tgaccgcggg ccgagcacga ttacgatgcc ggatgcgttt cgctctgttt ttgatcaggc
    13921 gggagtggtg atggagaact atgtgcagct gtacgagctg gaacctcgga cacgtaatgt
    13981 ttttgcggat ggaacggtgg tcgatctgtc tagaaatcgc ggctggatga aagagcagat
    14041 tgctgtgtac agtccggagg atgccttgcg ttatgatgca tttatggatg aatctgctgc
    14101 attgtatgcg gaggctaatc gtcattttct cggcaaactg ctgctgaacc cgtctgataa
    14161 atacaaattc cagatgctgc gcagtctgct tcgggtgcgg cctacggtca ggctggataa
    14221 cctgctgcgc aagtatttca gccatccgca tacactcgcg atgttcgggc ggtacgctac
    14281 atatgtaggg tcatcgccgt atctctctcc ctccattttt gccatgatgg gtcatgtgga
    14341 agcagaggta ggcgtctatg gggtcaaagg cggaacgtat cagctgattg aaggcatgac
    14401 ccggctcgcg caggaaaaag gcgtgcagat tatgacgggg gtagaggtac accagatcgc
    14461 ggttcggcat ggcaaggtgg tcggcatgga tacggatcgg ggctttatgg aagcaaagca
    14521 ggttgtggct aacggagatg tgcttagtgt aaacaggcta ctgctcgcgc cggagcatcg
    14581 gaaacgaatg agtgatgccc ggattgcaaa atatgaaccg tccatttcag gctttgtcac
    14641 cctggccggg gtacgcagga aatacgatca gttgttgcat cacacggtct tttttccaga
    14701 acagtacaag ccggagtttg atgatatttt ccgtgaccgc aggatgcctt ccgatccaac
    14761 gatatacatc tgttactccg gttactccga agcaggcatg gctccagaag gagccagcaa
    14821 tctgttcatt ctagtgaacg cgccatattt gtctcaagcg tggaactggg aagagcagaa
    14881 gtatcgttat ggtgagtttg tgctggagca attggaggcg cgtggtattg gcggattgaa
    14941 acaatcggaa gtgttaattt tttatacacc gcaacatatt gaacgggata cgcttgctca
    15001 tcaagggtcg atctatggca tttcctccaa ttcggtgaaa cagactttca tgcggccagg
    15061 caatcagagc aaagatgttc aagggctctg gtacgttggc ggcacaaccc accctggcgg
    15121 cggaaccccg attgttacgt tgtccggaca gcttgtgggg gagcaacttg cagccgagct
    15181 ggggaggtag ggcagggtac gtggagggca ggtgtgccga acctcgattc ttttaatcaa
    15241 ttcaatgaat ttaatgaggc agaacgaggt gttgcaagac tctaatgaaa tacaatagct
    15301 gctccattgt ttgactgaat gagaacaagg gttgcaagga ctaacaatgc agcatagttg
    15361 atccgagctt taataaagca aatagctgct ccaaaactct aatgagttca tgtttgagat
    15421 catggggttt tggagtgtcc tttcattagg ttgagaggaa cggtatacta gatagagttg
    15481 tccattgatg ggcgctaccc tatagggttt gtctaagaac cgaatggata agccgagcgg
    15541 ttagcgacac aggatgattt attggatagg cgtgagtaga taggacgatg agtgattgcc
    15601 actagtccat tgcaccgcat ttacatagaa acaagagtta cagagcaact cagcatgggg
    15661 tagggagtat gaagcaaaac aacgcaaaca agcctatcct gcacatcatt ctcacatagg
    15721 aggtctcatc atgaacgaac aagagcgagc cggcaaacgg ctgctgcccg aagtggcaac
    15781 gggggaacgg aagctggagc acgtgcgcct ctgtctggag gagaatgtgg caggagaagg
    15841 cataacgagc ggattggaga agtatgcgtt tcgtcatcat ccgctgccgg agctggactt
    15901 tgaagaggtt catctggaca cttcgttcct tggtaaaaaa atgcgtacac ccttgctcat
    15961 cagttcgatg acgggtggaa gcaaaacgac aggcgccatc aatgaacgcc tggcaagggt
    16021 agccaacgcc agaggctggg cgctcggcgt aggctcgatc cgggctgcgg tggagcagcc
    16081 ggaactcgca agcacatttg atgtccgccg ctgggcaccg gacatcccgg tcatcgcgaa
    16141 cctgggcgcg gttcagctga actacggctt cagcacagct gatttccagc gtgccgtgga
    16201 tatcgccggc gcagatctgc tcgtgctgca tctgaacacg ctgcaggaag tattccagcc
    16261 cgaaggcaat acgaacttca gtggtctgta ccaacgaatc gagaaattgt gtcgtgagct
    16321 ggaagtgcct gttggtgtca aggaagttgg ttttggcatc gatggcgtga cggcacagcg
    16381 actatacgaa gcgggcgtag ccttcatcga tgtggctggt gcgggcggga caagctgggt
    16441 acaggtggag aagtatcgta acaataaccc ggtacgccgg gcggctgcgg aagcttttgc
    16501 cgattggggc attccaacgg ctgaatgcat ccaggacgtg cgcgcgctga accccgatgg
    16561 ggcgatgatc ggtagcggcg gactgtatac tggcgtggat gccgccaaag ccctcgcgct
    16621 cggtgccgac ctcgcaggtt ttggtcgctc tttgctcgaa tccgccgtca cctccgacga
    16681 agcgctgtcc gaacggctag agcaggtcga attcgagcta cgcaccgtca tgtttggcat
    16741 cggcgcaggc agcgttgcag atgtgaaacg gacagaacgt ctggttgagc ggcggtaatg
    16801 ttggtggacg gggacgccga ggagtcagag tggagaatcg aaggttagtg agcggtgtgt
    16861 ttgtatcggt tcagtagctc taacgatccc acagaacctt attctgcgct ttttgaggtg
    16921 tttataaatc taacgatcac cagaagcgct atttgtgtga aaaccttcaa aagtgggcga
    16981 aaaacgtggc ttttcaagta aataagctcc ctggtgatcg ttagaattcg tggagtccca
    17041 tcgtagcaat cgctgatcgt tctaaatccg ctcaactggt atggggcggt tttttttgta
    17101 tattaaagta aaatatttac aagtaaaata ttgatgatac ttaccaaaat attgtatgat
    17161 cgcattaagc tttatttctt gggaaggcgg tgtcccgttg agcgaaaaaa ctacaattcg
    17221 tgaccattta gaacattttt taaaaaggaa tcgaatgacc atcaatcgct tttccgagat
    17281 ttctggcgtg aattccggga cattgagcgg cacgttgaaa ggaaatcgtc caatcgggtt
    17341 aaatcaattg gatcgcatta cggctggcat tgggatgcct gaaggcgaat tatatgaact
    17401 gtacataaat gaatatttag tggactctaa tctggattgg agaaggctta gaccttttct
    17461 atatcgttgt gcagagctag gccatataac acatatggag acagcggtga actatgtgat
    17521 ggataacctt tcctacatac ctatgttgtt tgaattggca gagcagctgc atagcgaagg
    17581 caagatggag gcttgtaaac cgttgtaccg ctgtgtcgct gaaagtgaga aattgcaaca
    17641 ttcggaacgt ctggctttat gccaatatcg tctgttttcg ataggacttt cgaatgacca
    17701 ggttcataat cttacgctag ccacacgatt cgaactattt gtagaacgtc ttgatgagca
    17761 atatcaattc gatgcgctga atgaactgat caatgtgtat gcatccttgc gccgctggga
    17821 caaagtgaaa gaatttgccg accagttaca gatcaaagct tttattcaat atgacgccaa
    17881 gaaaacatta cgagaagtgg agactaaaac gaaaaagaag attgtgtatt atgctttgta
    17941 ttcgtatctt gctcttgctg aggtcagtta tcaacatggg aaatatgaag aaacgcttca
    18001 gtatgtctca aaatatgctg attacagctg gatcaaagat cctactgaag aggaaaagat
    18061 ggtgattctt cagtttcagg attggtcaga aggaaataac tactatttca gattgctgtc
    18121 aggtgaaaca gagttgattc cagaatattt aacgtatatc tctgaccgaa aaaaagaaat
    18181 atttcctgca ctatgcgcaa ttgtgaccgc agcaaatcga tataatgtca atattgacga
    18241 tgtacttgag cagtatcaat ctcatctgga ttacgaggaa cagagcagtt gcttcggaaa
    18301 aatgagcaaa caatacacca atgatcaata tggtattttg cttgcagggt taggtacgta
    18361 ttatttaaga aataaccact atgacagagg cgtagcttat attcgtcaag gcatggaatt
    18421 tgcgattgaa aacatgaata aagatggact tctcgattgt ctaggcctgt ttgatgattt
    18481 gcagtacgtc gtcactggac taggggtcaa gcctagcgcc gagttgctta ttgagaagat
    18541 acagagattg tacagtccgg aacgatgaaa gggtacaaaa agtagacaat agagaaggct
    18601 gagtaacgta tccacatgta agtataggct aggtgcatcc cctaaggtca aaatagatta
    18661 ggctcgttgc actctgatgc atcctccgtt ttgaaattcc ttatacagac agttgcttag
    18721 attgtcaaaa ggtgtttcag aaaagggtgt ttttttgtcg ttttcactgt tggagtttat
    18781 ttgaattttt gctaattagc aggatgttct aaaataatac agcagggagg ggtgttatgg
    18841 agcgagacga actcaaactg cggatcgaag aagcaaggga gagactccac caattaaaga
    18901 cggagtacgg cgagcttctt caccctcagg tgatccgcca atctatggtg ctggatgaac
    18961 ttattaatat gtacaatcat gttaaaagga taaagccgat ggagtaatcc atcgacctct
    19021 gggcgagaaa ctttggccgg tcgctcgtcc ttctatttta acataagtgg atgtgtagaa
    19081 agagaaacat tcaatttaag tacaattttc cttcacagtc acattatcgt tagttatcgt
    19141 gatgagggaa gttcctgaca cagattctgt atatccacag gctgtttttg tataggtatt
    19201 gccgcgactg tccttaaata tgacgtagac ggaactttcg cctaaaaaat gcaattttgg
    19261 agtatactta attttttttc cgctaacgat ttcttcgcta aaggtataga gcaggtcgga
    19321 atcttctttt ttatctgctg tgctcgaatc gagaatgggt tgcttccaat tcgttatgcc
    19381 tgtcttaatc tgaataatgt catagtctga ctgattatca attgtaattc tgagtttgcg
    19441 gaacggatcg atggcattta gaaaactcat cactacaatg gtgcccagtg caaggaacag
    19501 gccaagggca atcattattt ttattttgga aaagggacga cgtggtttgg tgtgcatggt
    19561 taaaccgtcc tttctattcg attgttttat acgggtgtct cgtattaaag atataaacgc
    19621 aggaatgcat gcaaaagttg gtgcaggagc attattttac agtgtatgtt caatgaataa
    19681 ggtacaatac gaaggagaac gaacagatct atagaggata tacgcatgaa gacgtgtaaa
    19741 gtcgattagg tgatgagtgc tcaacataag tagttgaggt gcctggaatg agttcattta
    19801 atgaggttca tgcagtggga tacttgaaga ggtgctgaac tgtacataaa gatcacatgt
    19861 aggtcatcct aatattcaca ccgaagtgat cacacctgga taaggaggaa ataacatgga
    19921 actgtctcca atgaatacgg aacaatttgc gagtttccgc agccgttcaa ttgaagattt
    19981 tgcacaggaa aaagtagaag caggaacgtg ggcgccggag gaggcgctag gacaggcaga
    20041 ggaatcgtat gagcgttatc tgccggaagg gttagatact ccaggggcat atgtgtttaa
    20101 tctggtgcat ccggtggacg gcattgtagg atacatctgg tttaacatta cggagaatcg
    20161 ccgggggaaa gaagcctttc tgctggatat cgtggtggaa gaagcatatc gcggcaaagg
    20221 gtacggtaca gaaacgatga atgcactcga aaagaccgcg agaagtcttg gggtgaatcg
    20281 cattgggctg catgtgtttg gacataatga gcgggcaagc agcctgtatc gcaagatggg
    20341 ttatgaagtg acggacttga cgatgtacaa ggaaatcaaa ggctagcatg aaccagggat
    20401 ttgaagaagg agatggctgc gggtgaatcg gcgaagttcc ttgatgcctt ggggtttgtc
    20461 atatataatg gataggatta tccataccga acaagtaatg aatgaggagt tgtcatatac
    20521 atggctttga aagcaggaat agtggggctt ccgaacgtcg gaaaatctac gttgtttaat
    20581 gcaattacac aagcaggtgc cgagtcggca aactatccgt tttgtacgat tgacccgaac
    20641 gtggggatcg tcgaagtacc ggacgagcgt ttggacaaat tgacagaact cgttgtaccg
    20701 aaaaaaacag tgcctaccgc atttgagttt gttgatatcg ccggtctggt gcgcggagcg
    20761 agcaaaggtg aaggcctggg taacaagttt cttgcccaca tccgtgaagt ggatgcgatt
    20821 gtgcatgttg tacgttgctt tgtggacgag aacatcactc acgtcgatgg caa
//
