LOCUS       NZ_RIAS01000008        23982 bp    DNA     linear   CON 13-MAY-2024
DEFINITION  Paenibacillus amylolyticus strain 27C64
            NODE_8_length_296431_cov_19.1408_ID_15, whole genome shotgun
            sequence.
ACCESSION   NZ_RIAS01000008
VERSION     NZ_RIAS01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus amylolyticus
  ORGANISM  Paenibacillus amylolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 296431)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Paenibacillus amylolyticus 27C64 has a diverse set of
            carbohydrate-active enzymes and complete pectin deconstruction
            system
  JOURNAL   J Ind Microbiol Biotechnol 46 (1), 1-11 (2019)
   PUBMED   30377865
REFERENCE   2  (bases 1 to 296431)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2018) Microbiology, University of Georgia, 120
            Cedar St, Athens, GA 30602, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-MAR-2015
            Assembly Method                   :: SPAdes v. MARCH-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 93.0x
            Sequencing Technology             :: Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003719335.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:42:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,967
            CDSs (total)                      :: 5,826
            Genes (coding)                    :: 5,778
            CDSs (with protein)               :: 5,778
            Genes (RNA)                       :: 141
            rRNAs                             :: 5, 10, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 10, 9 (16S, 23S)
            tRNAs                             :: 113
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 8 of 48
            Pseudo Genes (incomplete)         :: 39 of 48
            Pseudo Genes (internal stop)      :: 7 of 48
            Pseudo Genes (multiple problems)  :: 6 of 48
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:46:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 31191
            Orig. end                         :: 55173
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RIAS01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23982
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23982
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23982
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13982](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13982)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            28..1092
                     /gene="mtnA"
                     /locus_tag="EC604_RS15300"
                     /old_locus_tag="EC604_15210"
     CDS             28..1092
                     /EC_number="5.3.1.23"
                     /GO_function="GO:0046523 -
                     S-methyl-5-thioribose-1-phosphate isomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /gene="mtnA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689544.1"
                     /locus_tag="EC604_RS15300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15210"
                     /product="S-methyl-5-thioribose-1-phosphate isomerase"
                     /protein_id="WP_123064994.1"
                     /transl_table=11
                     /translation="MTTPEHQPLSSLNWKKDKLEMLDQRLLPETILMLKLYTPEEVWES
                     IHSMKVRGAPAIGIAAAFGVVLGAKAYDGIAIQGWLDHVKSVCAHLATSRPTAVNLFWA
                     LDRMMQKANQVVEAGLSLDESTDALEAEALLIQKEDEEVCRMIGEHALPLFEDGMGVLT
                     HCNAGGLATAKYGTATAPMYLAQERGIHLKVFADETRPVLQGARLTAFELQQAGIDVTL
                     LCDNMAGMVMSKGWVQAVIVGTDRVAANGDVANKIGTYSLAVLAKAHNIPFYVASPLST
                     IDLSTTSGDLIPIEERAAEEVTEGFGKRTAPQGVKVFNPAFDVTPNEYVTAIITEKGIV
                     RAPFQENLAALFAE"
     gene            complement(1321..1623)
                     /locus_tag="EC604_RS15305"
                     /old_locus_tag="EC604_15215"
     CDS             complement(1321..1623)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349131.1"
                     /locus_tag="EC604_RS15305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15215"
                     /product="DUF1805 domain-containing protein"
                     /protein_id="WP_123064995.1"
                     /transl_table=11
                     /translation="MVTMEPIVVGEHVLVGVEVKLPKTTLLTINTSKGYIMCGALDVGL
                     LNEKLGDRKIVAARAVGVRTLEQLLHAPMESVTTEAEALGITVGMTGVEALLKMI"
     misc_feature    1706..1722
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.63"
                     /tool="antismash"
     gene            1900..2499
                     /locus_tag="EC604_RS15310"
                     /old_locus_tag="EC604_15220"
     CDS             1900..2499
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009227083.1"
                     /locus_tag="EC604_RS15310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15220"
                     /product="hypothetical protein"
                     /protein_id="WP_123064996.1"
                     /transl_table=11
                     /translation="MKQTLSNQDDVGYLFNVDILIKSRSNALALQSLIEFINKEEQIAD
                     YRIHSGIELGQIIEAMTQDRTNSTDSNQNFLESPISSNEQLTSIKSDQIVNSVSSKSQP
                     QESVAKESNSKADKKKSTADTSHVADSNSFDAWIESLIKENRLTRIVVNNKHGKHQSIP
                     CRILNFDRDNNVVSIYHVDEKQVYTFRTNEIDEFLL"
     gene            complement(2653..3039)
                     /locus_tag="EC604_RS15315"
                     /old_locus_tag="EC604_15225"
     CDS             complement(2653..3039)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689551.1"
                     /locus_tag="EC604_RS15315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15225"
                     /product="DUF423 domain-containing protein"
                     /protein_id="WP_123064997.1"
                     /transl_table=11
                     /translation="MQRRWMMLGAILTMLSVAIGAFGAHMLKDKIGASAIATYETGVQY
                     HMIHALALLIVGLTAGQLGASTKLKWAARLLFAGIIIFSGSLYVLSISGIKILGAITPI
                     GGVAFIAGWLLFAMDVWQRGKTSL"
     gene            3224..3700
                     /locus_tag="EC604_RS15320"
                     /old_locus_tag="EC604_15230"
     CDS             3224..3700
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS15320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_15230"
                     /product="hypothetical protein"
                     /protein_id="WP_123064998.1"
                     /transl_table=11
                     /translation="MNNYNSPNSDNHNTSSYPNDSNPYNTSADGYTLPPKSAEINETHL
                     KHSGPGIASFVVGLVGFLGHLVTFALMSLVLNNTIELLGSSISREELAIHPAFVLGSFA
                     FLVCLILNFIGLILGIIGLALKNRRKVFAIIGTILSGLLILFFTVLVLGGIYLT"
     gene            3812..4660
                     /locus_tag="EC604_RS15325"
                     /old_locus_tag="EC604_15235"
     CDS             3812..4660
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689553.1"
                     /locus_tag="EC604_RS15325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15235"
                     /product="DegV family protein"
                     /protein_id="WP_123064999.1"
                     /transl_table=11
                     /translation="MPRIKIFADSTSDLAPEWIQQYEIGIIPLYVVFGEESLKDGEEIK
                     PEQLYERVRRHGSLPKTAAPSPADFMTAFQPYIEQGDDIFYISLSSELSSTYQNALLAS
                     SEFPEGRISVVDSKNLSSGIGLMVMKAVHAAEQGQTLAQITQQIEAMKSTVRTEFVIDT
                     LEYLYKGGRCSGMQNLIGSLLKIRPVIRVTDGKMSPAYKVRGKREKALDQMLQNTLSNK
                     DQIDRDLMIVVHTMAEEDAINLKKTLQEQTGARVELTTAGCVICSHCGPKTTGIIYNTI
                     H"
     gene            complement(4803..5582)
                     /gene="pdaA"
                     /locus_tag="EC604_RS15330"
                     /old_locus_tag="EC604_15240"
     CDS             complement(4803..5582)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdaA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689554.1"
                     /locus_tag="EC604_RS15330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15240"
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="WP_123065000.1"
                     /transl_table=11
                     /translation="MKRTVLYLLLGLFTINMLASQAEASPINGAYHFGFKKSQNGELPS
                     IDQEGFKSILEHNHAIFLGDTKQKELYLTFDNGYENGFTPAILDVLRAKKVPAAFFVTG
                     HYLKDQPDLVKRMAAEGHIVGNHSWSHPDMTRISNTQIKEELEKVKSEVHRLTGQQATF
                     LRPPRGIFNNRTLAESYAQGYVNVFWSIAYKDWDTNVQRGAQYAQQQVLKQLHPGAVIL
                     LHSVSKDNTEALGAIIDEARKQGYAFKSLDDLKTRTY"
     gene            complement(5683..6090)
                     /locus_tag="EC604_RS15335"
                     /old_locus_tag="EC604_15245"
     CDS             complement(5683..6090)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689555.1"
                     /locus_tag="EC604_RS15335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15245"
                     /product="hypothetical protein"
                     /protein_id="WP_123065001.1"
                     /transl_table=11
                     /translation="MSDNIQNIQVGFVCPDCGQEVNTYFMQQQVNTVRCEGCNRAYTLM
                     KPTIGDEILLDWEQEALYHKLRAERSEKDNHNMSALIIKVIELLTWRDQGDGQTRAIQT
                     VKEWLATSGKPQTLLELFHQPTPSSRENKRI"
     gene            6239..6877
                     /gene="cysC"
                     /locus_tag="EC604_RS15340"
                     /old_locus_tag="EC604_15250"
     CDS             6239..6877
                     /EC_number="2.7.1.25"
                     /GO_function="GO:0004020 - adenylylsulfate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006790 - sulfur compound metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cysC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689556.1"
                     /locus_tag="EC604_RS15340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15250"
                     /product="adenylyl-sulfate kinase"
                     /protein_id="WP_123065002.1"
                     /transl_table=11
                     /translation="MSKEDRHITWQASSLNRQDRENNNGHRSRTIWFTGLSGAGKSSIA
                     FALERTLHEQGVRCYVLDGDNVRHGLNRDLGFTAADRQENLRRIGEVSKLMVDAGLLVL
                     SAFISPYAQDREMVRQLFEPEDFIEVYVRCSIEECERRDPKGLYKKARKGEIPHFTGIS
                     APYDIPTSPSFVIDTEQCSIEEAVQEIVQHLQRIGALHLPVQTNSSLTY"
     gene            complement(6989..8794)
                     /locus_tag="EC604_RS15345"
                     /old_locus_tag="EC604_15255"
     CDS             complement(6989..8794)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689557.1"
                     /locus_tag="EC604_RS15345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15255"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_240036915.1"
                     /transl_table=11
                     /translation="MRKLHHISGPVLYWNLLAMILIGLMEGIGIYMLVPMLSLIGVFEM
                     GSSGIHIPWLTELLHRFSENGQLLLVLLAFVFILSGQAWMQRLQTIRNTRIQQQFIRTL
                     RLETYSALLRARWSFFLQKRKSDFNHILTTELARVSQGTSLVLQMAASLIFTAIQIGLA
                     FWLSAKLTSLVLVSGLLLFVLLRKFVRRAKQIGDQTSEFSQSYYYGITEHFNGIKDIKS
                     NMLESSHIHWFERICRQIERNVVQFSQLNTGTQLIHRVSAAMIIASFIYLSLQVMSVPP
                     ANLLLIILIFSRLWPRFTAIQSNLEYIGSMLPAFRMVRELQDQTEKNCEIREQISLVQE
                     TSTSTSQPIAPIDLVDGIMCEGVNYRYEGSDTYALKNVQAFIPAQGMTAIVGKSGAGKS
                     TLIDLIMGLVKSESGRILIDGIPLTEEQLLNWRSSIGYVSQDPFLFHTSIRENLRLVDP
                     DASEEQMWRALQFSSSASFVRKLPQGLDTIIGDRGIRLSGGERQRLVLARTMLRNPSVL
                     VLDEATSALDSENEQQIHEALERLKGHVTIIVIAHRLSTIRTADRVIVLEEGRVIQEGG
                     YQQLSMDSSGTFSKLLHMQAGAAGQ"
     gene            complement(8815..10011)
                     /locus_tag="EC604_RS15350"
                     /old_locus_tag="EC604_15260"
     CDS             complement(8815..10011)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="EC604_RS15350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15260"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_123065004.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 9.2e-63, bitscore:
                     206.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHETELYSTGFPKELKLILSLLRDDLADLTSEEIRGRLHEIDWP
                     LFLQLVVHHRLYSVIYVKLKMLDLPSIPEAVVESLKQQYTINTFRMLHLTAEMEQVCGA
                     FRERGIRTITLKGPALAHDLYGDVSMRTSKDLDILIPVQNVEEAGRILVDLGYQCKEGE
                     RALTVRSWKWREHHICYVHPVKRTQVEIHWRLNPDSGRETEFELLWKRSRFSSYTQTPV
                     RMLEREDLWVYLVTHGARHGWFRLRWLLDIDQMIRTMPLDMKKVERRLKAEGRLSIGSQ
                     TLHLVSDLLNTPLGDPYLSIMATRERTGKRLAREGAMFMNEMLGSPEELHKYPSYLFSL
                     RSTRQKWFFFIERLYPSTWDVHQFPLPRSLFFLYFPLRPFLWFWRRFKKSTMAERGKV"
     gene            complement(10001..10483)
                     /locus_tag="EC604_RS15355"
                     /old_locus_tag="EC604_15265"
     CDS             complement(10001..10483)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689559.1"
                     /locus_tag="EC604_RS15355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15265"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_123065005.1"
                     /sec_met_domain="PF13471 (E-value: 2.9e-26, bitscore: 86.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRKVKSYFSLPGTIRRLVWEAYILLAWARMQKARPFAKIAPGLG
                     TPMVETPVTGLNRTQVTEIRNISKAILLASKYTLWESQCLVMAIAAMKMLERRNIASTL
                     YMGTARNKQGQLMAHAWLRSGKLIVTGADTMDQYTVVGVFGKRCPEKGSGEIVYDT"
     gene            complement(10488..10787)
                     /locus_tag="EC604_RS15360"
                     /old_locus_tag="EC604_15270"
     CDS             complement(10488..10787)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689560.1"
                     /locus_tag="EC604_RS15360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15270"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_123065006.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.8e-30,
                     bitscore: 97.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.3e-20, bitscore: 66.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAITPIDANDVVTRKDGNLVSDMGGEKVMMSISSGKYYNLGSTG
                     GRIWELIAEERTLNDLIETLASEYDIQAEQCREQVVAFLEHLSREGLIHISRGV"
     aSDomain        complement(10503..10754)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EC604_RS15360_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="6.50E-31"
                     /identifier="RREFam002.1"
                     /label="EC604_RS15360"
                     /locus_tag="EC604_RS15360"
                     /protein_end="95"
                     /protein_start="11"
                     /score="97.2"
                     /tool="antismash"
                     /translation="VVTRKDGNLVSDMGGEKVMMSISSGKYYNLGSTGGRIWELIAEER
                     TLNDLIETLASEYDIQAEQCREQVVAFLEHLSREGLIHI"
     gene            complement(10756..11730)
                     /locus_tag="EC604_RS15365"
                     /old_locus_tag="EC604_15275"
     CDS             complement(10756..11730)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS15365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_15275"
                     /product="aldolase"
                     /protein_id="WP_123065007.1"
                     /transl_table=11
                     /translation="MLPVHYEAYGLRWLSHILMPELQRAPMDVETKQVVADVQIESFDL
                     TALWESWEVGSDNFVARDGCLFFRIEDTGLFLMEHGKRIVVSTVSGADPKKVRLFILGT
                     CMSVIMMQRGILPLHGSAVVIDGWAYAFVGHSGAGKSTLSAALASRGYPLLTDDVVALT
                     WDAGGRAIVSPGYPQQKLWQPSLEGFGMKQQDYATVHAEITKYAIPVQHYFHERAVPLG
                     GIYELVPEPDQESGSVHLQEVSGLERLHLLCSHTFRGGLVNRQGLAQWLFETASRLSAS
                     VEINRISRTGHHFTAFEMVDRIINHIRKGVHIEYDSNYTYRCE"
     gene            complement(11872..12009)
                     /locus_tag="EC604_RS15370"
                     /old_locus_tag="EC604_15280"
     CDS             complement(11872..12009)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689562.1"
                     /locus_tag="EC604_RS15370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15280"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_123065008.1"
                     /transl_table=11
                     /translation="MQNEKKEWQAPVLEVLDVNETMAGVGYRQIDWITVHDADMYDPTS
                     "
     gene            complement(12051..13982)
                     /locus_tag="EC604_RS15375"
                     /old_locus_tag="EC604_15285"
     CDS             complement(12051..13982)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017689564.1"
                     /locus_tag="EC604_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15285"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_123065009.1"
                     /sec_met_domain="GATase_7 (E-value: 1.1e-22, bitscore:
                     74.4, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 9.9e-19, bitscore:
                     62.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIAGIVHKEGQQALWEDSWRLYASLGHIPADTTGVWKGDEAFL
                     SCHAQWITLESVNEKLPLYDEESQLTITSDAILDNREQLADQLQISRAELAGLADSELI
                     LRAYRRWGEDVASYLLGDFVFAIWDERRRMLFAARDITGMRAFYYRHDGSRFAFCTLMK
                     PLLELGGVQKALDENWLSEFLAIPDMHDSADIHSTVYRGVNQLPSAHTLTFRNGKIELR
                     QYHRWDDVEPLRLKSDDEYVEAFREVFSQAVGSRLRTHRQVAAALSGGLDSGAVAGFAS
                     GTLRSQGKQLQAYSYVPVPDFTDYTSKTLLADERPFIRSTINHVGNISENYLDFEGRSP
                     LSEVDTWLNMMEMPYKYFENSFWIRGFYEKASEQDAGILLTGARGNFTISWGPALDYYA
                     SLLKSGRYFRWLREMQQYSERTGMAFSRIARITGRKAFPDWFKGNNKGTAQPAGAQLIH
                     PDLARRTGVLERLKSILVLQGGARADALQVRADKFNNLAIANKNGAVATKCSLRYRAWE
                     RDPTSDPRVIRFCLSVPIEQYVRQGTDRSLIRRATSPELPDKVRLNQRVRGVQPADWLH
                     RILPDWQTFTSELHTLCSDSQVAGILNTDRIKSALANFPSPRPELASHPDLRLMMHSLI
                     VYRFIQKF"
     gene            complement(13979..15247)
                     /locus_tag="EC604_RS15380"
                     /old_locus_tag="EC604_15290"
     CDS             complement(13979..15247)
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280289.1"
                     /locus_tag="EC604_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15290"
                     /product="sulfotransferase"
                     /protein_id="WP_123065010.1"
                     /transl_table=11
                     /translation="MIDTQGNGLVFLLCIPRSGSSLSTVMLQNHSRIFATQEMWFLMNL
                     VDLSKADSRAYGGSSIIRQFYQAMVSEDVFEKACRSFALEIYNGFLEGSGADFIVDKSP
                     RYYYMLEWLDRLFPQSRRIHLQRNPLSVAASFKKVNRHTGEGFDLIQSLNHSKLNMKAV
                     DLTLGLTRLNDYFAEAHPLAYELKYEQLVMKPQEELEKLCAFLGITYEQGMERYGQFVD
                     STKADMFYSMGVGDPFLSSHQEAHQDSVNNWKNILERREVELYCRVLGANLFHRMGYSE
                     QLQEAEDWTGVQFQAEPDAEILERLKQQLVLATECRWQPNYRMEAPMNGDKDWSPASSG
                     SEGHETAKMDPALAAMATIRQLQAALRAADQRLERGYTERERLKKQLHAAHSKLQRIKS
                     WIPFGHRISAWASQRKIVRGGKS"
     gene            complement(15606..16946)
                     /locus_tag="EC604_RS15385"
                     /old_locus_tag="EC604_15295"
     CDS             complement(15606..16946)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005551006.1"
                     /locus_tag="EC604_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15295"
                     /product="MFS transporter"
                     /protein_id="WP_123065011.1"
                     /transl_table=11
                     /translation="MDKRAVKAWIMYDWANSAYATTVLAAVLPVFYASVATSTLDKDTA
                     ASYLAYTHSIGMLCVALLTPLLGTLADLSGRKGEFLRVFAITGIVATLGFSVIGEGDWL
                     LASTLLVLTTIGFAGGNTFYDAMLPDLVPAERRDTVSSKGYAYGYIGGGLLLAVNLLMI
                     QQPGWFGMPSTLAGTRLAFISVSLWWLLFSLPIFRYAPRRPASPELPSSVTGYAKVGVR
                     RLRQTFGQIRRFPQLLRMLVAFWFFNDGINTIILMATIYGTSIGIGTSDLMLALLITQF
                     IGFPCTLLLGAWAQRWGAKQVLLVSLSVYICIVILGYFMTQALHFYLLAGLVGVVQGIS
                     QSTARSLFSNLMPAARTGEYFGFVNITGKFASIFGPFVFGYVGQITGSTRWGILSLIFF
                     FVAGIAVLLTVKVQKGMQDAQSADQEELERLQGIGAAGNGKDVTFTG"
     gene            17203..18369
                     /gene="yhbH"
                     /locus_tag="EC604_RS15390"
                     /old_locus_tag="EC604_15300"
     CDS             17203..18369
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="EC604_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15300"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_123065012.1"
                     /transl_table=11
                     /translation="MSNSHQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFVYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIVEAEVSIEELEDILFAELELPDLKQKDKDLIETHTVVFNDIRKKG
                     MQSNIDKKRTILENLRRNATTGNPGIHHISPDDLRYKTWEDKIIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SVYMKALDIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIGELMKRSNMFGYGEVN
                     QYNRSSTLMSAYRHIKMDQFMYYVIKEKGEVYKALRSFFQKREGGSLG"
     gene            18366..19802
                     /locus_tag="EC604_RS15395"
                     /old_locus_tag="EC604_15305"
     CDS             18366..19802
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="EC604_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15305"
                     /product="SpoVR family protein"
                     /protein_id="WP_123065013.1"
                     /transl_table=11
                     /translation="MTDEIRELEYAIAEIMEIADGFGLDYYPMRYEICPSDIIYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLDGNSLIQNKLIVAHV
                     LAHCDFFKNNARFSKSNRNMVESMAATADRISNYEMEYGTEAVEAFIDAVIAIQEHVDP
                     QLIKPRHLDKQRYMEMKIREQRGEKAPKPEGQYDDLWSLDHLQTEEKPTDSLQVHHFPP
                     EPEKDIMWFIQEFSEVLTDWQRDIMSMMREEMLYFWPQMETKIMNEGWASYWHQRIIRE
                     LDLSSEDTIEFAKLNSSVVQPSKQSLNPYYLGLKIFEDIERRWDHPTREEQERWGRQPG
                     QGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKKGPDWKITDKSWENIRDQLVF
                     SRINGGSPYLVVQDADYLRTGELVLKHQYEGIELDLKYMERTLPYLYRLWGRTVHVETR
                     VEDKPIWFTYDGKKHHRKFL"
     gene            complement(19890..22373)
                     /locus_tag="EC604_RS15400"
                     /old_locus_tag="EC604_15310"
     CDS             complement(19890..22373)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003388755.1"
                     /locus_tag="EC604_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_15310"
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="WP_123065014.1"
                     /transl_table=11
                     /translation="MEHIHGTYNLQLVILSYFIASLASYAALDLAGRVSLTSGRARHWW
                     VACGAISMGLGIWSMHFVGMIAFVLPMHVSYSMDKVILSVLLAISASGVALEFAGRPSN
                     RISKLVFAGLLMTAGITSMHYVGMAAMSVPITYEPTLVVLSVLIAALASYAALWLMFYF
                     NRPESKYHWIYKIGSGLIMGLAIAGMHYTGMAAAHFYQAQVIPESLNRQVESEVLAYLI
                     AAGTFVTIGLTLFGNFINQRMIQKDQRIRENEQWYHALYHNHSDAIVSVDREGIIKGIN
                     AVVTTITGYPEKRVIDRPINQIIEQINVQCSSKDNAHTWDNQELQQRHYMAKMRNTQNE
                     LLDLSIAVIPVIIDDTHVGSHILIKDITEETQAQQNIRHQALHDPLTGLPNRRKLDEVL
                     ASTIQVCEQKQHKFAVLVMDIDRFKMINDSLGHSIGDVFLKEVSSRIVTVIEASHPQAN
                     SNVTLARMGGDEFTMVVTGEQADEKQVVRLAEKIVEAIKQPYRLKENDFYVTASIGIAM
                     YPEHGAGTDALIKHADSAMYEVKKNGKNGYQFYTAQLDSELYERIELEGYLRKALERNE
                     MVLYYQPQIRTLDSRMIGVEALIRWQHPLKGLLAPDVFIPLAEETGMIYDIGNWTIREA
                     CRQMKLWHASGGPLIPVSVNLSSQQFHQSNLVEQVQNALTETGLEAKYLELEITESMMM
                     DAAVSTAILNELSALGVKISLDDFGTGYSSLSYLKHFPIHKLKIDRSFVTDITESHSDQ
                     AIVATIISMAQNLKMEVIAEGIETKGQLDILMQNDCREIQGYYFSRPLPANEVENNFFV
                     PLRLLGERNTVFHSV"
     misc_feature    22610..22625
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     misc_feature    22789..22802
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: strong, score: 21.97"
                     /tool="antismash"
     misc_feature    22987..23000
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    23919..23939
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.39"
                     /tool="antismash"
ORIGIN
        1 ctaacattat tgaacggagg aacatccatg acaacccctg aacatcagcc tctgtcttcg
       61 ctaaactgga aaaaggacaa gcttgaaatg ctcgatcagc gtctgctgcc cgaaacgatt
      121 cttatgctga aactgtacac tcccgaggaa gtatgggagt ccatccattc catgaaagta
      181 cgcggtgcac ctgccattgg tatcgcagca gccttcggcg tagtgctcgg agccaaagct
      241 tatgatggca tcgctattca aggctggctg gatcatgtca aatccgtctg tgcacatttg
      301 gcaacatcac gtccaacagc ggttaatctt ttttgggcat tagatcgcat gatgcaaaag
      361 gctaaccaag ttgtagaagc tggtctaagt ctggatgaaa gcacagatgc gcttgaagca
      421 gaagcattgt tgattcagaa ggaagacgaa gaagtatgcc gcatgatcgg tgaacatgcc
      481 ctgcctttat ttgaggatgg aatgggtgta cttacacact gtaacgcagg aggtctggcg
      541 acagcgaaat acggtacagc aaccgctccg atgtatctag ctcaagagcg tggcattcat
      601 ctgaaagtat ttgctgacga gacacgtccc gtcctgcagg gcgctcgttt aactgcattt
      661 gagctacaac aggccggaat tgacgtaacg ttactctgtg acaacatggc gggtatggtc
      721 atgtccaaag ggtgggtaca agctgtcatt gtgggtacgg atcgggtcgc agcaaacggt
      781 gatgtcgcca acaaaattgg tacatacagc ctggcagtgc tcgccaaagc gcataatatt
      841 cctttttatg tagcaagtcc actatcaacc attgacttgt ccacaacgtc cggcgatctg
      901 attccaatcg aagagcgtgc tgctgaggaa gtgaccgaag gatttggcaa gcgtactgca
      961 ccgcagggcg ttaaggtgtt taatccagcc tttgacgtaa ccccgaacga atatgttacc
     1021 gcaattatta cggaaaaagg tattgttcgt gcgcctttcc aggagaacct cgcggcttta
     1081 tttgcagaat gaaaaatggt gagcatgtag caacatgaga agatttcgaa catgcagaac
     1141 tttgttgagg tctttgtatc aactaccttc gaggaataat tgagaatgga aatatatatg
     1201 acaaccatat agcaaccatt gctatgggtc tgtaaagaga agggacaaga cgaatacatc
     1261 cgtcttcgtc ccctttttct gttctatttc tatggtgcaa aatgaaaacc gacacgtgct
     1321 tcagatcatc tttaacaatg cttctacacc tgtcatacct actgtaatcc ccaaagcctc
     1381 tgcctcggtc gtcaccgatt ccattggtgc atgaagcagc tgctccagtg ttcgcacgcc
     1441 tacagcccgt gcggccacaa tcttgcgatc gcccagcttc tcattcaata accccacatc
     1501 aagagcaccg cacatgatat accctttgga tgtattaatc gttaacagtg tcgttttggg
     1561 aagtttcact tctaccccaa cgagcacgtg ttctcccacc acaatcggct ccatcgtcac
     1621 cataatttca cgatccacct cctcttcaac agatcacgat aattgtatgc ctcttggtga
     1681 atcgccgtgt ggacacctgc cgtgatgaac aaaaagtggg taatcaagat gtgggtaacg
     1741 ctctccgtca gaacgtagga aaggaacgag caaaggataa ttctaagttt taaaattaac
     1801 cgatttctga gcctttggta ctatgatttc catcatatta gtgctatagt atattagagt
     1861 acatacgtgc ttatacatta tttaacgggg ctgggatgaa tgaaacaaac cttatccaat
     1921 caagatgacg tcggctatct atttaatgtc gatatactta ttaagagccg ttcaaatgca
     1981 ttggcactgc agtccctgat cgagttcata aacaaagaag aacaaattgc ggactatcgg
     2041 attcactccg gaattgagct tggtcaaatc attgaagcta tgactcagga tagaacaaat
     2101 tctactgact ctaatcaaaa tttcctggag tcaccaatat catctaatga acagttaacc
     2161 tccatcaagt cagaccagat cgttaattcg gtttcgtcca aatcacaacc acaagaatca
     2221 gttgccaagg aatcaaattc aaaagctgac aagaaaaaat ctactgcaga cacttcccat
     2281 gtcgctgatt cgaattcgtt tgatgcctgg attgaatcct taattaaaga aaatcgcctc
     2341 acccggattg tcgtaaacaa caaacatggc aaacatcaaa gcattccttg tcgaatactt
     2401 aattttgacc gggataacaa tgtcgttagc atttaccatg tggatgaaaa acaagtctac
     2461 acatttagaa caaacgaaat tgatgaattc ttgttataac cttgaagatt taagcaaata
     2521 cttagcacaa acttaattca aagtagattt tcacccacaa cgtccaaacc aaaaagcaac
     2581 ctgatctgga atgagataaa cattcaggca caggttgctt ttattatacg atcattcttg
     2641 taacaaggac tgttacaaac tggtcttgcc ccgttgccag acatccattg caaacagtaa
     2701 ccagccagca ataaaagcta cgccaccgat cggtgtgatc gctcctaaaa ttttgatacc
     2761 cgatatgcta agtacgtaca ggcttcctga aaaaatgatg atacccgcga acagcaaacg
     2821 cgctgcccat ttcagcttcg ttgatgctcc gagctgccca gccgttaatc cgacaattag
     2881 taaagcaagc gcatgaatca tgtggtattg tacccctgtt tcgtatgtag caattgcact
     2941 tgcaccaatt ttgtccttaa gcatatgtgc accgaatgca ccaatagcca ccgacagcat
     3001 cgttaatatg gctccaagca tcatccatct ccgttgcata tccactctct cccttgattc
     3061 gtttcaaacg ctttgactcc atatattgta gcgaattcaa gctctaaagt aaaagaaatg
     3121 ccttatgaat atcgaatccg gaatcgctgg acactataca gggtaataaa cattcagtat
     3181 tctatataaa ttatgatatc ttttaagggg gcagcgtgtt ctaatgaata attacaattc
     3241 accaaactca gataaccata acacctcatc gtatcctaac gactcgaatc cctataatac
     3301 aagtgccgat ggctatacac tcccgccaaa atcagcagaa atcaatgaaa cacatcttaa
     3361 acattcaggg ccggggatcg cgagttttgt tgttggattg gttggttttc tagggcatct
     3421 cgtgacattt gcgctgatgt ctcttgtact gaataacacc attgaactgc tgggatcgtc
     3481 aatcagccgg gaagaactcg ctattcatcc ggcattcgtt ctaggttctt tcgctttcct
     3541 tgtctgcctg attcttaatt tcatcggtct tattcttgga attattggat tagcgctcaa
     3601 aaatcgtagg aaagtctttg ccatcattgg cacgattttg agtggtctac ttattttgtt
     3661 tttcacagtg cttgtacttg gcggtatata cttgacgtaa tgctttcctt gagtgtcccg
     3721 gttctttata attaagctaa gccgcttaac ctttgccccg ttatactcaa catatgaaag
     3781 accaaatatt tgaactctaa aggagattga catgccacga attaaaattt ttgcggacag
     3841 caccagcgat ctggctcctg agtggatcca gcagtacgaa atcggcatca ttcccttgta
     3901 tgtggtgttt ggtgaagaat ccctgaagga cggagaagag atcaaaccag agcaattgta
     3961 cgaacgtgta cgtcgccatg gttctctgcc caaaactgca gcaccttcac ccgctgattt
     4021 catgaccgca tttcaacctt acatagaaca aggcgacgat attttttaca tctccttatc
     4081 ttctgagctt tcttcaacct atcagaacgc tctgctcgcc agttctgaat ttccagaggg
     4141 acgcatctcc gtagtggatt ccaaaaatct ctcctcaggc attggcttga tggtgatgaa
     4201 agctgtgcat gcagcagaac aaggacaaac tttggcccag attactcaac agattgaagc
     4261 catgaaatca acggtgcgta cagagtttgt tattgataca ctcgaatact tgtataaagg
     4321 cggacgctgc tccggtatgc aaaatctgat tggcagctta cttaaaatcc gtcccgttat
     4381 tcgggtaacc gatggtaaaa tgtcacccgc ctacaaagta cgcggtaaac gagaaaaagc
     4441 gctggatcaa atgttgcaaa atacgctcag taataaagat cagattgatc gggatttaat
     4501 gattgtcgtt cataccatgg ctgaggaaga tgcgataaac ctgaaaaaga cgctgcagga
     4561 gcaaaccgga gcgcgcgtag aattaactac ggcgggttgt gtcatttgca gtcattgcgg
     4621 gcccaaaacg accggaataa tctataacac aattcattag cacgaatgga aacaataatt
     4681 taagggcatg ctcagcagat cgctaggcat gccctttatt tgtttcggat gacaactaag
     4741 caagttttat tactttgata ctcaactaac gtaatccatg ctcgtcttgc ccaactcctt
     4801 cattaatagg ttctggtttt tagatcatcc agacttttga atgcgtaacc ttgcttgcgt
     4861 gcctcatcaa tgattgctcc aagcgcctcc gtattgtctt tcgacacgga atgcagcaag
     4921 atgacagccc ctggatgaag ctgtttcagc acttgttgtt gagcatattg tgcgccacgc
     4981 tgtacattcg tatcccaatc cttataagct atagaccaaa acacattgac atatccctga
     5041 gcataactct cagcaagtgt acgattgttg aaaataccgc gaggtggacg caaaaatgta
     5101 gcctgttgcc ccgtgagacg gtgcacttca gatttcactt tttccagttc ctctttaatt
     5161 tgtgtgttgg aaattcgagt catatccgga tggctccatg aatggttccc aacaatgtgc
     5221 ccttcggctg ccatacgttt gacaagatcc ggctgatcct tcaaataatg accagtaaca
     5281 aagaaagctg ccggaacctt cttcgctcgc aatacatcca gtattgcagg tgtgaaccca
     5341 ttctcatatc cattatcaaa agtcagatac agttcctttt gtttggtatc ccccaagaaa
     5401 atggcatgat tatgctccaa aatagacttg aacccttcct gatcaatgga aggcagttcg
     5461 ccattctgac ttttcttaaa gccaaagtgg tatgctccgt taatgggaga tgcttctgcc
     5521 tgtgatgcca gcatgttaat ggtgaacaag ccgagcagca gatatagcac cgttcgcttc
     5581 atgttatccg ctcctgtccc tgaaatttca gtttgtttaa tggtccacaa acaccttcag
     5641 gtaatatgcc gcaagagcgt ctatattatg taatcattag cgctatatcc gtttattttc
     5701 gcgtgaggac ggcgttggtt gatggaaaag ctcaagcaaa gtctgaggtt tgccgctggt
     5761 agccagccat tcctttactg tctggatcgc acgagtctga ccgtccccct gatcgcgcca
     5821 ggttagaagt tctatcactt tgatgatgag tgcggacatg ttatgattgt ccttttcaga
     5881 gcgctctgca cgcaatttat gatatagagc ctcctgctcc caatccagca aaatttcatc
     5941 tccgatcgtc ggtttcatga gtgtataagc ccgattgcaa ccttcgcagc gaaccgtgtt
     6001 cacttgttgt tgcataaaat aggtgttcac ttcctgcccg caatcagggc atacgaaccc
     6061 tacctgaata ttttgaatgt tgtcactcat gatcttgtcc tcctgctctc tgtgtataac
     6121 atctataccc gatatacaga cggttcacgc ttctgtgata gataattttc atggtctata
     6181 atctagcaaa tatgttaaaa tattatgcat aggatcagtt gaaatgaggt gggataacat
     6241 gtcgaaggaa gatcgacata ttacttggca agcatcgagt ttaaatcggc aggatcggga
     6301 gaataacaac ggacatcgta gtcgcacgat atggtttaca ggtttatccg gggcaggtaa
     6361 atcctccata gcctttgcac tagagagaac cctccatgaa caaggtgttc gctgttatgt
     6421 gcttgatggt gataatgtaa ggcatggatt aaatcgggat ctcggtttca ccgcagcaga
     6481 tcggcaggaa aacctgcgtc gcatcgggga agtaagcaag ttaatggtag atgcgggact
     6541 gcttgtgctt tcggcattta tttctcccta cgcacaggat cgggagatgg tcaggcagct
     6601 gtttgaaccg gaagatttca ttgaggtcta tgttcgttgt tctattgaag aatgtgagcg
     6661 gcgtgatcca aagggacttt acaaaaaagc tcgcaaaggt gaaatccctc attttactgg
     6721 catctctgct ccctatgata tcccaacttc tccttcattc gtcattgata ccgaacaatg
     6781 cagcattgag gaagctgttc aagagatcgt gcagcatctg cagcgaatcg gtgccctaca
     6841 tcttcctgta cagaccaact catccctgac ttattaatta aataataaag atgaaaggcg
     6901 tccctttgcg gcacgccttt tttgcattct attcctttct agtagcgctt gcttcactat
     6961 aatccgttat agggacacaa cttatcgttt actgtccggc agcgccagct tgcatatgaa
     7021 gcagtttgct gaaagtgcct gacgaatcca tagataattg ctgatagccg ccttcctgga
     7081 tgacccgtcc ttcttccaaa acaatgacac ggtctgcggt tcggatcgta gagagtcgat
     7141 gtgcaatgac aataattgtg acatgtcctt ttaatcgttc gagcgcttca tgaatctgct
     7201 gttcattttc actgtcgagt gcactcgttg cttcatccaa taccagtacc gagggattgc
     7261 gaagcatggt ccgtgccagc acaagacgct gacgctctcc acccgacagg cgtataccgc
     7321 gatcacctat aatggtgtcc aggccttggg gaagcttgcg aacgaatgaa gcggaggaag
     7381 aaaattgaag tgcccgccac atctgttctt cacttgcatc cggatcaacc agacgtaagt
     7441 tttcacgaat gctggtatgg aacaaaaaag gatcttgtga gacatacccg atcgaacttc
     7501 tccagttcag taactgttcc tcagtcaaag gtattccgtc tatcagaata cgaccactct
     7561 cagacttcac cagacccatg atcagatcaa tcaatgtgct tttccccgcc cccgatttcc
     7621 caacaatagc agtcatacct tgagccggaa taaacgcttg cacgttcttt aatgcatacg
     7681 tgtcacttcc ctcataacga taattcacac cctcacacat gatgccgtcc accaaatcga
     7741 ttggagcaat aggctgggaa gtagatgtac ttgtctcttg caccaaagag atttgttcac
     7801 ggatctcgca gtttttctcc gtctgatcct gcaactctct caccatccga aatgcgggca
     7861 gcatcgagcc gatgtactcc agattagact gaatcgcagt aaaccttggc cataatcgtg
     7921 agaaaatcaa aataatcaat aacaggttgg ctggaggcac cgacatcacc tgtaaagaaa
     7981 ggtaaataaa cgaagcaatg atcatcgccg ctgatacccg gtgaatgagc tgtgtacctg
     8041 tatttagctg actaaactgc accacattac gctcaatctg cctgcatatg cgttcaaacc
     8101 aatggatatg ggagctctcc agcatattgc ttttaatatc cttgatcccg ttaaaatgct
     8161 ccgtgatgcc ataataatag ctttgggaga attcggaagt ctgatctcca atctgtttgg
     8221 cacgcctaac aaactttctt agtagtacaa ataacaacaa accactgaca agtacaagcg
     8281 atgtgagctt tgcggataac cagaaagcca gcccgatctg aatcgctgta aaaatcagcg
     8341 aggctgccat ctgcaagact agacttgttc cctgacttac cctggcaagt tctgtggtta
     8401 atatatggtt gaaatcggat tttcgttttt ggagaaaaaa agaccaccgt gcccgaagta
     8461 gtgcactgta ggtttccagg cgcagcgttc gtatgaattg ctgctgaata cgggtattgc
     8521 gaatcgtctg aagacgctgc atccatgcct gtcccgagag gataaataca aaagccagta
     8581 gaacaagtag caattgacca ttttccgaga atcggtggag tagctccgtt aaccagggga
     8641 tatgtatacc agaagagccc atctcaaaaa caccaattaa acttagcata ggaacaagca
     8701 tgtagatgcc gattccttcc attaaaccaa tcaagatcat agctagcaga ttccaatata
     8761 aaacaggccc agaaatatga tgcagttttc gcatgaaata gtttaactcg gagatcatac
     8821 ctttcccctc tctgccatcg tgcttttttt gaagcgccgc cagaaccaga gaaatggacg
     8881 taacggaaaa tacagaaaaa acagagaacg tggtagcggg aattgatgca cgtcccaagt
     8941 acttggatat aaccgctcaa taaagaaaaa ccatttttgc ctcgtactac gaagagagaa
     9001 taaataagat ggatatttgt gcagctcttc tggactacct aacatttcgt tcataaacat
     9061 cgcgccttct ctcgccagtc gctttcccgt gcgctcacgc gtagccataa tcgataaata
     9121 cggatcgccc agtggggtat ttagcagatc cgaaacgaga tgtagtgtct gggaaccgat
     9181 ggataaacgc ccctctgctt tcaaacgacg ttctaccttt ttcatatcga gcggcatcgt
     9241 acgaatcatc tgatcgatat ccagtaacca ccgcagtctg aaccagccat gtcttgcacc
     9301 atgcgtcact aaataaaccc ataaatcctc tctttccagc atacgtacag gtgtctgggt
     9361 atacgaactg aatcggcttc gtttccacaa cagttcaaac tccgtttccc ggccagaatc
     9421 aggattaagc ctccaatgga tctccacttg agtgcgcttg acgggatgaa cataacagat
     9481 atggtgctcc cgccacttcc agctacgaac ggtaagcgcc ctttcccctt ctttgcactg
     9541 gtaaccaagg tcgacaagaa tacgcccagc ttcctccaca ttctgaaccg gaatcaaaat
     9601 atccaggtct ttcgaagtcc gcatggacac atcgccgtac aaatcatgag ccagagcagg
     9661 ccctttcagt gtaatcgtgc gaattccacg ctcccgaaat gctccgcaca cttgctccat
     9721 ctcggctgtt aaatgtaaca tacggaaggt attgatcgtg tactgctgtt ttaggctctc
     9781 tacaaccgct tcgggaattg acggcagatc cagcattttt aatttcacat aaatgacaga
     9841 atacagacga tgatggacca caagctgtaa aaaaagtggc caatctatct cgtgcagccg
     9901 gcccctgatc tcctcggaag ttagatctgc cagatcatct ctaagcaggc tcaagattag
     9961 cttgagctcc ttcggaaacc ctgtggaata cagttcagtt tcatgtgtca tagacaatct
    10021 ccccagatcc cttctcagga catcgtttgc caaacacgcc gacgaccgta tattgatcca
    10081 tcgtatctgc tccagtcacg atcagcttcc cacttcgcag ccaggcgtgt gccatcagtt
    10141 gtccttgctt attccgtgca gtgcccatat ataacgtact tgcgatatta cgtcgttcca
    10201 gcattttcat tgcagctatg gccatgacaa gacattggct ttcccataac gtatacttac
    10261 tggcaagcaa aatagctttt gatatgttcc ttatttcagt cacttgggtg cgattcaatc
    10321 cagttacagg tgtttcgacc ataggtgtac ccagccccgg agcaatttta gcaaacggcc
    10381 ttgccttttg cattctcgcc catgccagca ggatataagc ttcccatacc aaacgcctta
    10441 tcgtacctgg aagcgagaaa tacgacttca ctttacgaaa catgttctta cactccgcgg
    10501 gaaatatgga ttaaaccttc acgtgagaga tgctccaaaa aagccacaac ctgttcacgg
    10561 cattgttccg cctgaatgtc atattctgaa gcaagcgtct cgatcaagtc attcagcgtt
    10621 ctctcttctg caatcagttc ccagattcgt ccgcctgtac ttcccagatt gtaatatttc
    10681 ccggaactga tgctcatcat caccttttcg ccacccatat cactgactaa gttgccatcc
    10741 ttccgggtta cgacgtcatt cgcatcgata ggtgtaattg ctgtcatatt ctatatgcac
    10801 tcctttgcgt atatgattaa tgatccgatc caccatttca aatgctgtaa aatggtgccc
    10861 cgttctgcta atcctgttaa tctccacact ggctgaaagt cttgatgctg tttcaaacaa
    10921 ccattgggcg agtccttggc gattcaccag tccacctcga aaggtatgag agcagagcaa
    10981 gtgcagacgt tccagaccac ttacctcctg caaatgcaca gaaccagatt cctggtccgg
    11041 ctcaggtaca agttcgtaga ttcctccaag tggaacagcc ctctcgtgga agtagtgctg
    11101 aaccggtatg gcgtatttcg taatttcagc atgcaccgtt gcataatcct gctgcttcat
    11161 gccgaatccc tccagactgg gctgccataa cttctgctgc ggatacccgg gcgatacgat
    11221 ggctcttcct ccagcgtccc aggtcaaggc taccacatca tcggtgagga gaggataccc
    11281 acgtgaggcc agtgctgctg acaacgtaga ctttcctgcg ccagaatgcc caacgaacgc
    11341 gtaagcccaa ccatcaataa caactgcgct tccgtgcaga ggaagaatac cacgctgcat
    11401 cataatcacg gacatgcatg tcccgaggat aaacagcctg acttttttcg gatcggcccc
    11461 agacactgtg gagacaacga ttctcttgcc atgctccatt aaaaacagac ccgtatcttc
    11521 gattctgaaa aaaagacaac cgtcccgcgc tacaaaattg tcgctgccaa cctcccaact
    11581 ctcccacaac gctgtcagat cgaaagactc gatctgcaca tcagctacaa cctgcttcgt
    11641 ttcgacatcc ataggtgcac gttgcaactc aggcatcaga atgtgactca accagcgtaa
    11701 accataagct tcatagtgca caggcaacac gaaagcgtac ctccttcatt cattttatag
    11761 atatgaaaaa aagccctgat attcataagc tcaatattag ggcggaggcg aaaaggctga
    11821 tcggttgcat ttccgccctt taagtatgaa ctagctgggg aaactacaaa attaggacgt
    11881 tggatcgtac atgtcggcat cgtggacagt gatccagtcg atttgtctgt atcctacccc
    11941 tgccatcgtt tcattcacgt ccaacacttc aagaacgggt gcttgccatt cctttttttc
    12001 gttttgcatc gttttcacct cctttcaaga gcatatacct ttgccttgga tcaaaacttc
    12061 tgaataaagc ggtacacaat taaactgtgc atcatcaaac gcaaatctgg atgggatgcc
    12121 agttcgggcc tgggacttgg aaaattagcc agagctgatt taatccgatc cgtgtttaat
    12181 atgccggcaa cctgactgtc agaacacaag gtatgcagtt ccgaggtaaa cgtctgccag
    12241 tcaggcaaaa tacggtgtag ccagtccgca ggctgtacgc cccgtacacg ctgattaagc
    12301 ctcactttgt ccggcaattc cggtgatgta gctcggcgaa tgagtgaacg atccgttccc
    12361 tgtcttacat actgctcaat cggtacggag agacaaaatc ggatcactct tggatcactt
    12421 gtgggatcgc gttcccatgc ccggtaacga agggaacatt tggtggcgac ggccccattt
    12481 ttattcgcga tcgctagatt gttgaacttg tcggctcgca cctgtagtgc atcggctcgg
    12541 gcaccgccct ggagtacaag gatggattta agtcgctcca gcacgcctgt tctccgggcc
    12601 agatctggat gaatcagttg tgctcctgca ggctgagctg tccccttgtt atttcctttg
    12661 aaccagtctg ggaacgcttt acggcctgtg atccgggcga tgcgtgagaa tgccatccct
    12721 gttcgttcgc tgtactgttg catctcacgg agccagcgga aatatcggcc acttttcagt
    12781 agactagcgt aataatcaag tgcaggtccc catgagatcg taaaattgcc acgtgcgcct
    12841 gtcagcaaaa tgccggcatc ctgctcactc gctttttcat aaaatccacg gatccagaat
    12901 gaattttcaa agtatttata aggcatctcc atcatgttca gccacgtatc cacttcactg
    12961 agaggactac gtccttcaaa atcgagatag ttttccgaga tattgcctac gtgattaatg
    13021 gtggaacgaa taaatggtcg ctcgtctgct agtaacgttt ttgacgtgta gtccgtaaaa
    13081 tccggaacag gcacgtagct gtaagcttga agctgcttcc cctgactccg gagcgttccg
    13141 gaagcaaaac cggcaacagc ccctgaatcc agtccaccac ttaatgccgc tgcaacctgt
    13201 ctatgcgtcc gtaagcgcga acctacggct tggctaaaca cctcacgaaa agcttctaca
    13261 tattcatcat ccgatttgag tcgaagcggt tctacatcat cccagcgatg atattgcctg
    13321 agttcaatct tcccgtttcg aaacgtcagc gtatgcgcag agggcaactg attcactccg
    13381 cgatacactg tggaatgaat atcagccgaa tcatgcatgt caggaatggc caaaaattcg
    13441 gataaccagt tttcgtcgag tgccttctgt acccctccca gttcaagcaa tggcttcatc
    13501 aacgtacaga aagcaaatcg tgaaccgtca tgtcggtaat aaaatgcccg catgcccgtg
    13561 atatccctgg cagcaaacaa catgcggcgg cgttcatccc agatcgcaaa tacaaagtcc
    13621 cctagtagat aactggctac atcttccccc cagcgccgat acgcgcgcag aatcagttcg
    13681 ctgtccgcca gtccagccag ctctgctcgt gaaatctgca actgatcggc caattgctca
    13741 cggttatcca aaatggcatc tgaagtgatg gtcaattgac tttcttcatc atacagaggc
    13801 aatttctcgt tcacggactc cagcgtaatc cactgagcat ggcaactgag gaacgcctca
    13861 tcccctttcc atacccccgt tgtatctgcc gggatatgcc caagacttgc atagagtcgc
    13921 cagctgtcct cccatagcgc ttgctgacct tctttatgta cgattccagc tatagcgctc
    13981 atgactttcc tccccgaacg attttgcgct gggatgccca ggcgctaatt cgatgaccaa
    14041 atggtatcca tgatttaatt cgctgcaatt tgctgtgggc agcgtgcagc tgtttcttca
    14101 atcgttcccg ctccgtatac ccacgttcca gccgctgatc cgctgcgcga agagctgcct
    14161 gtaactgtct gatcgtggcc atagcggcta gtgcagggtc catctttgcg gtttcgtgtc
    14221 cctcactacc gctactcgca ggagaccaat ctttgtcgcc attcatcggc gcttccatgc
    14281 ggtaattcgg ttgccaacga cactccgttg ccagtactaa ctgttgcttg agccgctcca
    14341 atatctccgc atccggctct gcctgaaact ggactcccgt ccaatcttca gcttcctgca
    14401 gctgttcgct gtaccccatc cggtggaaca ggttcgcacc aagtacacgg caatacagtt
    14461 caacttctcg ccgttcgagt atatttttcc agttgttaac agaatcctga tgtgcctcct
    14521 gatgtgatga aaggaagggg tccccgacgc ccatactata gaacatgtca gctttcgtac
    14581 tatcaacaaa ctgaccatac cgctccatgc cttgttcata agtaatgcct agaaaagcac
    14641 ataacttctc cagttcttcc tgtggtttca tgacaagttg ctcatacttc aattcgtagg
    14701 ccaaaggatg agcctctgca aaataatcat ttaatcgcgt tagcccaagt gtcaggtcta
    14761 cggctttcat attgagtttt gaatgattca gactctggat cagatcaaaa ccttcgccgg
    14821 tatggcgatt tactttttta aaggatgccg ctacagaaag ggggttacgc tgaagatgaa
    14881 tgcgtctgga ctgcggaaac aaccgatcca gccattcaag catataataa taacgcggag
    14941 atttatcaac gatgaagtct gctccgctcc cttccagaaa tccattatat atttcaagag
    15001 caaagcttct gcacgccttt tcgaaaacat cttcggacac catcgcttga taaaattgac
    15061 ggatgatgga actgccaccg taagcgcgag agtcggcttt ggacaaatcg acgagattca
    15121 tcagaaacca catctcctgt gtggcaaata tacgactatg attttgtagc ataacagtag
    15181 ataacgaact gccactacgg ggaatgcata ataaaaagac aagtccgttt ccttgcgtat
    15241 ctatcaatgg cagcctctcc tctgtaaatt tataaaatat gccgtgggat cggatcgacc
    15301 ggatgatcat ttaccttgga aatgacaggg gatttcgaca ctctgagata caatatgtat
    15361 ttataccttt actctatgat acaaaatgta tcatgtcaat cttttatttt caccttttca
    15421 tactttattc gcttgcccat gatctaagta cgtaaccatg caaaaaggcc tccagatcct
    15481 gttatgagat gaacagaatc cagagaccga gataaaacaa taacagatac gacacacata
    15541 ccataccaat ctaaatctta cctaactaac ctaagcaact ctaacctaaa caaatctaac
    15601 taaactcatc cggtaaaggt aacatccttt ccatttccag ccgccccaat gccttgcaac
    15661 cgttccaact cttcttggtc ggctgactga gcatcttgca ttcctttctg taccttcacg
    15721 gttaataata ccgcaatgcc tgctacaaaa aagaaaatca gcgacagaat accccagcgg
    15781 gtcgaacctg taatctggcc cacgtaacca aatacaaatg gcccaaagat cgaagcgaat
    15841 ttccctgtaa tgtttacaaa tccaaaatac tcaccggttc gtgcagccgg catcagattg
    15901 ctaaacaggg aacgcgccgt cgattggcta atcccctgca caacgccaac caatcctgcg
    15961 agcagataaa agtgaagagc ttgggtcata aagtaaccaa gtataacgat acaaatatag
    16021 acacttaaac ttaccagtaa cacctgcttt gccccccatc gctgcgccca cgcacccaga
    16081 agcagtgtac atggaaaacc gatgaattgc gtaattagca gcgccaacat caaatccgat
    16141 gtgccaatgc caatgcttgt cccgtagatt gtggccatca gaataatagt attaatgccg
    16201 tcattgaaaa accagaatgc caccaacatc cgaagcaact gtggaaaacg ccggatctgc
    16261 ccgaaggttt gccgtaatct gcgtacgcca acctttgcat aacctgtcac ggatgaaggc
    16321 aactccggcg aggctggcct tctaggtgca tagcggaaga tgggaaggga gaacagcaac
    16381 caccacagcg aaaccgaaat aaatgctagt cgcgtacctg caagtgtact cggcatgccg
    16441 aaccatcccg gttgctgaat cattaacaga ttgactgcaa gcagtaaccc ccctccgata
    16501 tatccgtagg cataaccttt ggaggatacc gtatctcttc gttctgcagg aactaaatcg
    16561 ggtaacattg catcatagaa cgtatttccg ccggcaaagc caatcgtggt taacaccagc
    16621 agggtagacg caagcaacca gtctccttct ccgatcacgc tgaatccgag cgttgccaca
    16681 atccctgtga ttgcaaatac tcgcaggaat tccccttttc gtcccgatag atcagccagt
    16741 gttcctagca acggggttaa cagcgccaca cacaacattc caatagagtg tgtatacgca
    16801 aggtaagaag ctgccgtatc cttatccagt gttgacgtag caacagaagc atagaataca
    16861 ggaagcaccg ccgcaagcac ggttgttgca taagctgaat tggcccagtc atacataatc
    16921 caggctttta ctgcacgttt atccacactt aatccttcct ttacatgcat cagggttcga
    16981 tgctcagaat cagacctttt ttctattgta aaggaaagat atcacatatg ttcatgattt
    17041 ttgtaaaatc caaacatgta ccctgcttcg gcctctccta agccaagtgc agcgtatttc
    17101 attcatttta gttgagatcg catcacatat cgtccccgcc cgtgaatata cttaattacc
    17161 gacaggccaa actgtgccgc gtaatcaatg gggggtgcct acatgtcaaa ttcacaccag
    17221 ccttactcgt tcgtcgtatc ccgggaagat tggtcgcttc accgcaaagg gtaccaggac
    17281 cagcagcgcc atcagcaaaa ggtgaaagat gtcattaagc aaaatctgcc tgatctgatc
    17341 accgaagaaa atattatcat gtccgatgga caacaaatca tcaaggtacc catccggagt
    17401 ctggatgagt accgctttgt gtataactac caaaagcaaa agcatgtcgg tcagggggac
    17461 ggtgacagcc aagttggcga tgtcattggc cgtgatcctg catcacagaa gccaggcaaa
    17521 ggcgaaaaag ctggcgatca accgggtcat gacatcgtgg aggctgaggt cagcatcgag
    17581 gaattggaag atattctctt cgctgaactg gaattgccgg atctgaaaca aaaggacaaa
    17641 gatttaattg agacacatac cgtggtcttc aacgatatcc gcaaaaaagg catgcagtcc
    17701 aacatcgata agaaacgaac catactggag aacctgcgcc gcaacgcaac aacaggcaat
    17761 ccaggcattc atcacatcag tccggatgat ctccgttaca agacgtggga agacaaaatt
    17821 attccacagt ccaatgcggt cattatcgcc atgatggata catccgggtc gatgggatca
    17881 tttgaaaaat attgtgcccg cagctttttc ttctggatga cgcgtttcct tcgtcgtcag
    17941 tacgagaaag tcgaaattgt gtttctggct caccacacgg aagccaaaga agtaacggaa
    18001 gaggagtttt tcactcgcgg cgagagcggc ggtacgatct gctcctctgt atatatgaaa
    18061 gcactggata ttatcgataa gcgttatccg ccttccagct acaacatcta cccgttccat
    18121 ttctcggatg gcgataacct aacctccgat aatgagcggt gtgtgaagct gatcggcgaa
    18181 ttgatgaagc gcagcaacat gtttggttac ggtgaggtga accagtacaa ccgcagcagc
    18241 acactcatgt ccgcctatcg ccatattaaa atggatcagt ttatgtatta cgtcatcaaa
    18301 gaaaaaggcg aagtgtacaa agcactccgc agcttttttc aaaaaagaga aggaggcagc
    18361 ctgggatgac cgatgagatc cgcgaactgg aatacgccat tgctgaaatt atggagattg
    18421 ccgatggatt cggcctcgac tattacccga tgcgctacga gatctgcccg tcggatatca
    18481 tctacacctt tggtgcttac ggcatgccaa caaggttcag ccactggagc tttggcaaaa
    18541 cgtttcacaa gatgaaaatg caatatgatt ttggcctgag caaaatttat gaactcgtta
    18601 tcaactccaa cccctgctac gccttcctgc tggacggcaa ctctctgatt cagaacaaat
    18661 taatcgtcgc tcacgtactc gcacactgcg actttttcaa aaacaatgcc cgcttctcca
    18721 aatccaatcg caatatggtc gaaagtatgg ccgccacggc ggatcggatc agtaactatg
    18781 agatggaata tggcactgaa gcggttgaag ccttcatcga tgcagtgatc gctattcagg
    18841 agcatgtaga cccacagctc atcaaaccgc ggcatctaga caaacaacgt tatatggaga
    18901 tgaagatccg cgaacagcgt ggtgaaaaag cgcctaaacc ggaaggtcaa tatgacgacc
    18961 tgtggtcgct cgatcatctg cagaccgaag aaaaacctac ggatagtttg caggtacatc
    19021 attttccacc ggagccggag aaggatatta tgtggttcat ccaagagttc tccgaggtgc
    19081 ttaccgattg gcaaagggat attatgagta tgatgcgaga ggaaatgctc tatttctggc
    19141 ctcagatgga aacgaaaatc atgaacgaag gctgggcttc gtattggcat caacgcatta
    19201 tacgcgaact cgacctgagt agtgaggata ccatcgaatt tgccaagctg aattcttccg
    19261 tcgtgcagcc gtccaagcaa agtttgaacc catattacct gggactgaaa atttttgaag
    19321 atatcgaacg ccgctgggat caccccacgc gcgaggaaca ggaacgatgg ggacgtcagc
    19381 ctgggcaggg tcgggccaaa atgttcgagg tgcgcgagtt cgactcggat acctcgttca
    19441 tccgtaacta catgaccaaa aagttaaccg aggatctcga cctctacgtg ttcgagaaaa
    19501 aaggcccgga ctggaaaatc accgacaagt cctgggaaaa tatccgcgac cagcttgtat
    19561 tttcccgcat taacggcggc tctccgtatt tggtcgtaca ggatgcagac tacctgcgta
    19621 ctggcgaact cgtgttgaag catcagtatg agggcatcga gctggatctg aaatacatgg
    19681 agcgcacgct cccgtatctg taccgtctct ggggacgtac ggtgcacgtg gagacccgtg
    19741 tggaggataa accgatctgg ttcacctatg acggcaaaaa gcaccatcgc aagtttttat
    19801 aggcgggagt gacgaagttc ggatatatca tgaaaaacga aaaaagaggc aagttccaga
    19861 tactactcag gaacttgcct cttggccgtt tataccgaat gaaacaccgt gttacgttcc
    19921 cccagcaaac gcaggggtac aaagaaattg ttttccactt cattggctgg taagggcctg
    19981 ctgaaatagt aaccctgaat ctcccgacaa tcattttgca tcaaaatatc gagctggcct
    20041 ttggtctcaa taccttctgc gatcacttcc atcttaagat tctgggccat cgagataatt
    20101 gtggctacga tcgcctgatc gctgtggctt tcggtgatat ccgtaacaaa cgagcggtcg
    20161 atcttgagtt tgtggatcgg gaaatgcttc agataactca acgagctgta tcccgtacca
    20221 aagtcgtcca gactgatctt cacacctaaa gcggacagct cgtttagaat cgccgtggac
    20281 accgctgcat ccatcatcat gctctctgta atttccagtt ccagatattt ggcttccaga
    20341 cctgtctcag ttaaagcatt ctgcacctgc tccaccagat tcgactggtg aaattgctgg
    20401 ctggacaagt tcactgacac cgggatcaga ggcccgccgc tagcgtgcca aagcttcatc
    20461 tgtctgcagg cttcacgaat cgtccagtta ccaatatcat agatcatgcc ggtctcttcg
    20521 gccagcggga taaatacatc gggtgcaagc agccctttaa gcggatgttg ccagcgaatc
    20581 agagcctcta ccccgatcat tcggctgtcc agcgtacgaa tctgcggctg atagtacagt
    20641 accatctcat tacgctccag tgctttcctt aaataacctt cgagctcaat ccgttcataa
    20701 agttcagagt cgagctgagc cgtatagaac tggtaaccgt tcttgccatt tttcttgact
    20761 tcgtacatgg cggagtccgc atgtttaatc aaagcatctg ttcctgcccc atgttcaggg
    20821 tacatggcaa taccgatact tgctgtaacg taaaaatcat tttccttcaa acgataaggt
    20881 tgcttaatcg cttccacaat tttttctgca agtcgaacca cttgtttctc atccgcttgt
    20941 tctccagtga ctaccattgt aaactcatcc ccgcccattc gggctagcgt aacattagag
    21001 tttgcctgag gatgagaagc ttcaattacg gttacaattc ggctactcac ttctttcaga
    21061 aacacatccc cgatggaatg tcccagagag tcattaatca tcttaaaccg gtcaatgtcc
    21121 atgaccagta cagcaaactt atgctgtttt tgttcacaga cttgtatcgt agaagccagc
    21181 acttcatcca gcttacgtcg attaggcaac cctgtaagtg gatcatgcag agcttgatgc
    21241 cgaatatttt gctgtgcctg ggtctcttct gtaatatctt taatcaagat atggctcccg
    21301 acatgggtgt catcaatgat gactggaatg accgcaatac tcagatcaag aagttcattt
    21361 tgtgtatttc tcattttcgc catgtaatgc cgctgttgca attcctggtt gtcccatgtg
    21421 tgagcgttat ccttactcga acactgtaca ttgatctgct caataatctg attaattggg
    21481 cggtcaatca cccttttctc aggatatcca gtaattgtag tgactacagc gttaatgcct
    21541 ttaatgatac cttcgcgatc cacggaaacg atggcatccg aatgattatg atacagggca
    21601 tgataccact gttcattttc acgaatacgt tgatctttct ggatcatccg ttgattgatg
    21661 aaattaccga ataatgtgag accaattgtc acaaacgttc ccgctgcaat gaggtaagca
    21721 agaacctctg actccacctg cctgtttaaa ctctcaggta ttacttgagc ttgataaaaa
    21781 tgggctgctg ccattccggt gtaatgcata cctgcaatcg ccaatcccat gatcagtccg
    21841 ctgcctattt tgtagatcca gtgatattta gattccggac gattgaaata aaacattagc
    21901 cacagcgccg cataggaagc aagagccgca atcagaacgg ataacactac aagagtcggc
    21961 tcgtaggtaa tcggaaccga cattgccgcc atccccacat aatgcataga ggtgatacct
    22021 gcagtcatca gtaatccggc aaaaacaagt ttgctaattc ggttggacgg gcgacctgcg
    22081 aattccaatg ctacccccga cgcggaaata gctaacaaaa cggacaagat caccttatcc
    22141 atggaatagg aaacgtgcat aggcagcaca aaagcgatca tgccaacaaa gtgcatcgac
    22201 cagataccca gtcccataga gatcgcccca caagcaaccc accagtgacg tgcccttccg
    22261 ctcgtcaaag atacacggcc tgcaagatca agtgctgcat aagaggctaa cgacgcaatg
    22321 aaataggata aaataacaag ttgtagattg tacgtgccat gtatgtgctc cactcactct
    22381 gtcctttcag ccgggtaatg ctcatatgta tgttgaatgt aaaaaaagaa gcgagtgcgc
    22441 tgcctggatg acaggcactc cctccttagc atttgacttt gcgactagcg acttagtcat
    22501 aaaccgattg gcatacaatg aaacccgcta atgatgaatg tttatagtct aaacgtccca
    22561 gctctgaaaa tcaacactta tttccagaag cacagcgcat ttcaccctgg tcacttattt
    22621 gttacacttc attaaacatc ctgatctaaa gcttgatcag taattctact tcttcatcag
    22681 tagcagacta ccgaatccgg acgtatcgcg gtacgaattg cctgaaggat cactccacat
    22741 gaagacactg ctacgtttcc catccccagc accgtcatca ttcacctgta gatcgaatcc
    22801 aatccattta ttttgcttag cgttaacatt ctccagcgga atagctgcct ccaccacata
    22861 tccatccttc gtcttacgtg cacttgattt gaacaactct ttacgggcat tacccccgaa
    22921 cgaagtttca ttatcgaaat taactcgata ctgggcatca tcgtcctcat aactactcgt
    22981 ttgattttta ttcagatcaa tgaatagctc aatggaatct tgttcatgtg cattagcact
    23041 ttttttactg agcaaaggat ctttgacatc agcaagtacg taaagatact tttcatccca
    23101 cagcaacttc gccttggcct tagcaccggc atctcctgca accttaacat ccgttgtgat
    23161 ggtcactgct tttttccata gcttatcttc cttaccatct acaacaggag ttccatatga
    23221 aactttgact tgttttaatg caggacctaa cttaagtttg ccccgacttt cctttttctg
    23281 cggttgctga ttattcgtat cgttccagac aataacggaa gttttatggt taggctgttt
    23341 atccgtaatg cggaaatcca gagataacac cttgccttcc gctagatcag ctgcggagaa
    23401 cggcagtgat gcatagacaa catatcccga tttattctcc ttcacttggt acagcttctg
    23461 atctttgcct ttgccgccat cccgatgaaa gacatattgt ccatcttccg gtgtcgggtt
    23521 tttcttgctc gttgccaaat cttccgggct gacaaacacc tctacctggt cgcctttcag
    23581 acgtgtggcg tctttgactt caatgcgcag gttcagtttt ttcccatccc ataatgtttt
    23641 cacttgacct gtagtccctg ctgtgccttc gattacatgt gaaaccggtt tggcctgaac
    23701 agctccccag ataatatctt cctgcccttt accatctggc aaagatactt tggattgtgc
    23761 ggccgtccat tcatttcgat atacaggcaa ggaggccggg tcaactagcg cccagtaagc
    23821 aggtttggct ttcaatttac ggtcaaacag cagcggtgca tcctttctgc ctttgactgg
    23881 gaaatcatcc agccatgtgc cgtcatcagc aagtccccat aacgtcacac tgtccataac
    23941 accacgatca tcaaactcct tgaacagatc aaacaacgca cg
//
