LOCUS       NZ_RIAS01000003        21533 bp    DNA     linear   CON 13-MAY-2024
DEFINITION  Paenibacillus amylolyticus strain 27C64
            NODE_3_length_478439_cov_17.0614_ID_5, whole genome shotgun
            sequence.
ACCESSION   NZ_RIAS01000003
VERSION     NZ_RIAS01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus amylolyticus
  ORGANISM  Paenibacillus amylolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 478439)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Paenibacillus amylolyticus 27C64 has a diverse set of
            carbohydrate-active enzymes and complete pectin deconstruction
            system
  JOURNAL   J Ind Microbiol Biotechnol 46 (1), 1-11 (2019)
   PUBMED   30377865
REFERENCE   2  (bases 1 to 478439)
  AUTHORS   Keggi,C. and Doran-Peterson,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2018) Microbiology, University of Georgia, 120
            Cedar St, Athens, GA 30602, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-MAR-2015
            Assembly Method                   :: SPAdes v. MARCH-2015
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 93.0x
            Sequencing Technology             :: Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003719335.1-RS_2024_05_13
            Annotation Date                   :: 05/13/2024 02:42:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,967
            CDSs (total)                      :: 5,826
            Genes (coding)                    :: 5,778
            CDSs (with protein)               :: 5,778
            Genes (RNA)                       :: 141
            rRNAs                             :: 5, 10, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 10, 9 (16S, 23S)
            tRNAs                             :: 113
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 8 of 48
            Pseudo Genes (incomplete)         :: 39 of 48
            Pseudo Genes (internal stop)      :: 7 of 48
            Pseudo Genes (multiple problems)  :: 6 of 48
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:46:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 428625
            Orig. end                         :: 450158
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RIAS01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21533
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="3"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21533
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21533
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11533](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11533)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    459..476
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 25.17"
                     /tool="antismash"
     gene            1188..1664
                     /locus_tag="EC604_RS08570"
                     /old_locus_tag="EC604_08545"
     CDS             1188..1664
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688854.1"
                     /locus_tag="EC604_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08545"
                     /product="Na+/H+ antiporter subunit E"
                     /protein_id="WP_123063748.1"
                     /transl_table=11
                     /translation="MAFQIVLNLIIAFVWMFLNNAWNGVGFLVGFMLGLLLIGGMRRFF
                     PQRFYIVRVWAIFKLIGLLFKELVRASIEVIREIIKPRLDIRPGIFTYRTQLSSDWEVT
                     LLCLLISLTPGSLPLEISGNQRKLFIHALDIKDEEKLRNDIQNTFEKAIMEVTR"
     gene            1664..1948
                     /locus_tag="EC604_RS08575"
                     /old_locus_tag="EC604_08550"
     CDS             1664..1948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688855.1"
                     /locus_tag="EC604_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08550"
                     /product="Na(+)/H(+) antiporter subunit F1"
                     /protein_id="WP_110896037.1"
                     /transl_table=11
                     /translation="MLSSLLFISLLILSLAILACLYRVLRGPSMADRITALDTIGINVI
                     AIVAVLSMMLQTQAYLDIILLIGILAFLSTVAFARYIERGAVFKNEGDR"
     gene            1932..2324
                     /gene="mnhG"
                     /locus_tag="EC604_RS08580"
                     /old_locus_tag="EC604_08555"
     CDS             1932..2324
                     /GO_function="GO:0051139 - metal cation:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0098662 - inorganic cation transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mnhG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688856.1"
                     /locus_tag="EC604_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08555"
                     /product="monovalent cation/H(+) antiporter subunit G"
                     /protein_id="WP_123063749.1"
                     /transl_table=11
                     /translation="MKEIVSSTAETGIGLLVLLGALLSALSAFGLLRLPDVYLRAHAAT
                     KSMTLGVFCVLSGAFFFFWYFDNYISARLLLGIVFVFITAPVAGHLNGRAAYRTDVPLW
                     EQSVQDELEPLLKGKKMNHEAKDMME"
     gene            complement(2653..3771)
                     /locus_tag="EC604_RS08585"
                     /old_locus_tag="EC604_08560"
     CDS             complement(2653..3771)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014906699.1"
                     /locus_tag="EC604_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08560"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_240036726.1"
                     /transl_table=11
                     /translation="MIAVGLGTDRVEVAEAASDHYKFDFGAGAVTNGYTGVSASTAYTA
                     ARGYGFNTPANMKNVSASGSGVASDAVQFLKFGTKSDNTFNVDLPNGLYEVKVTLGNTA
                     RASVAAEGVYQIMNMTGNGATDQFQIPVTDGQLNLLVTEGKAGTAFTLSALEIRKLSNQ
                     PVTNRTIYIGGDSTVCNYYPLASSVQGGWGQLLPSYVNNTTFQVRNMATSGQIARGFRD
                     DGQMEAILKYIKPGDYFILQLGINDTNAKNNTTEAQFKEIMRDMVRLAKNKGATVILST
                     PQGRATDFNSSNVHQAENRWYNASTRALAQEEGVTLVDLNKLSSAYFTSIGPAATLALY
                     MNGDSLHPNRQGASQLARIVAADLKRQGLNGF"
     gene            complement(3911..4930)
                     /locus_tag="EC604_RS08590"
                     /old_locus_tag="EC604_08565"
     CDS             complement(3911..4930)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688858.1"
                     /locus_tag="EC604_RS08590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08565"
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_123063750.1"
                     /transl_table=11
                     /translation="MQDIDNYLYQQTSLRGHSVYDADQDFTAWSRQLRDRVQERLGGFP
                     AEAAELQPVVLERTSCDGYIRERIEITTYTGLRMPIYLLTPEDVSATDVKRPAIVACHG
                     HGYGSREICGMEPDGSPRAGEPGLHKDFAVALVKRGYVVAAPELLGFGDRRLDEDREAP
                     PGASSCTKIAAHLLMVGQTLAGHRVYETTRVLDYLSTRPEVDSERIGSMGISGGGLVTA
                     FTAAMDERCKAVVVSGYASTFHGSILDRNHCLDNYIPGILQEAELPDIIGLIAPRPLFL
                     EIGSEDLVFPLHSAREAHERLKMIYKHAGAEQALDADYFDGGHEISGAKAYDWLEQVL"
     misc_feature    complement(5095..5104)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(5119..5820)
                     /locus_tag="EC604_RS08595"
                     /old_locus_tag="EC604_08570"
     CDS             complement(5119..5820)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS08595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_08570"
                     /product="hypothetical protein"
                     /protein_id="WP_205127918.1"
                     /transl_table=11
                     /translation="MTMQVLMFGIFFVFTIGQLGELEASLGLTIDGLVPLLHKLNETRE
                     HRVMFTNSLIAVGLLSSALVFALYVGIPHVLQFFTKEKAEKNLSFLLAVVSKPGKIMLA
                     VWLFALIRVVAMAIINGVLIWFIFTLLGFRSVWTTSLFSSGLTIILCIAAFLYMANAIV
                     WATNGSEAVLKIFRIFILVGIVAAFPAVNYLRMDFSFLDFRYVAYSGMICIVAAFVSQF
                     LMRLFKVEKIV"
     gene            complement(5910..6830)
                     /locus_tag="EC604_RS08600"
                     /old_locus_tag="EC604_08575"
     CDS             complement(5910..6830)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024700.4"
                     /locus_tag="EC604_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08575"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_123063752.1"
                     /transl_table=11
                     /translation="MGSQIIETRGLNLNLQGSHVLKNIDITTHSGQICALIGENGAGKT
                     STIRCITGLYPPTTGGCSIFGEPAYNMSQKNRNRFGIVFDEGGLYSEMSAWENVLFFAS
                     LRGMEKDKIAERYNRLVQHFELKTSLKVGRFSKGMKQKLMIIRELVHEPELLILDEPFN
                     GLDPDSKIFLRDKLSEICSDRGTSILISSHDLFDLEKIADQVIMIHQGRIVADQALQTI
                     TGISERYIVTCDNSQLVVSILQGIEGITVVNHTEQSVTFMVESEVIKQPLQVLMQHGIE
                     IQEFFKEKSSLEDFYRTTKQAAVQN"
     gene            complement(6856..8556)
                     /locus_tag="EC604_RS08605"
                     /old_locus_tag="EC604_08580"
     CDS             complement(6856..8556)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="EC604_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08580"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_123063753.1"
                     /transl_table=11
                     /translation="MMKKMFSNLMYLRPYLEGSRLLLVLSFGALAMVSLIAMPIPLITG
                     KIIDNLSSPQGTTHFLYQQVIIIICLHVIRYVLSLIGKYYIVKAGTRASNVLRMKMIGH
                     TVDMPMEFIDKHDKGYLMSRISESGSIGSLFSPSVINILIGVLDGVISVILLVRIHWKL
                     SLIVLAIIPLYVVVTVWYSRRMSDSTRKVSESSAEMAGVMFETLNGIEEIKVQGAKQRY
                     ISRIYTKTDQVITAILKQNRNINGYMESSSLLSSLSGAIVLLFSGIMILGKTLTLGEYV
                     SFTGYLAKVLGNVQAVATFGVTINPIMVSIDRVREYMDNKDEEFGRRMVLSEPIHSVNI
                     HNISYAYISGIEKRSVLDQLNVNLFTGDIVILNGANGSGKTTFVKLLLGLYPVNKGTIL
                     YNGMDISCLKLSDLRRRVSYISQKTYLFQGTILDNILPNAQPEQLVHLRALLEKYQLQP
                     FISDFPNELDTEIAHGGANLSGGQRQMIAFLRTVLANKEMVILDEPTANMDAIMKSRVI
                     QMIENEAFYKILVVISHDPDLFYLGKPLNLGESSREDGGQQFYMKNEDR"
     gene            complement(8556..8717)
                     /locus_tag="EC604_RS29855"
     CDS             complement(8556..8717)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS29855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_161556888.1"
                     /transl_table=11
                     /translation="MNNIIMVLSIVAIGILTVFLNRKVKNKSRMSMILAIVFVLYIATF
                     MIIGMFKN"
     gene            complement(8714..9958)
                     /locus_tag="EC604_RS08610"
                     /old_locus_tag="EC604_08585"
     CDS             complement(8714..9958)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="EC604_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08585"
                     /product="radical SAM protein"
                     /protein_id="WP_161556889.1"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-06, bitscore: 23.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.5e-06, bitscore: 22.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYFKTGSHCYIVQGERQASLYDLSENNMLRISPADASMLLELNRG
                     VPVEEVDNINYILLSQLIEQGMGSYYSHNAYIEKVRFGLPPSIRDFAKNRVRISNLYLN
                     INDECNLECSFCNTDSMVHRMTGCKRYGGFSQDNLMEEKDYRIVLQQSHKMGCRSLHII
                     GGEPLLKWELLSVILAEARQLGYSNIFIYTNLMDTGELNWEELSGVSLVIHTSSHNQDL
                     TNRMIENHPDFSNFYENMNKLKKTGISFYFNVVLNKMNYIFREEIVDYYKHFNPLGMQL
                     SFIHEIGDDPVYNELLFSDKGAQSCFTDLSFFHNVDFHPCLNGKLSVFRNGDVSVCPMM
                     RNETIGNVLKDSFKRIADQRDYQEYWTYTLDRVDSCRSCSSRYACSDCRAIESSAGGSL
                     SSKVYCKQALKESLV"
     gene            complement(10001..11533)
                     /locus_tag="EC604_RS08615"
                     /old_locus_tag="EC604_08590"
     CDS             complement(10001..11533)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="EC604_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08590"
                     /product="radical SAM protein"
                     /protein_id="WP_151458061.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     4e-10, bitscore: 34.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 5.2e-45, bitscore:
                     148.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-17, bitscore: 57.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.5e-12, bitscore: 41.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.6e-08, bitscore: 28.8,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRDVLFSTFLIQVKVGCIMNNIGVFETRQGNKYIFDGATNMVLS
                     ASEELAHTIESHDKLDRELIYEKADLPLRQLMKKWDLFKLHEVELSQDMILDELRTYPY
                     PQMILGLTENCNLRCKYCIFSGNYEEMRTHTFKRMEKETALKSVQKYIDYIEEWRAYAP
                     DKQPVISFYGGEPLLRFDLIQEVVAYVKQTGFKTMFSMTTNGTLLTDRIIEFLVTHNVM
                     ISVSLDGSKEMHDKNRVFVNEQGTFDVVYGNIRKLLAEIKRQGKEQILPMMILSCYENE
                     TDMVAMNDFFVREKHLLKSMGGRLSKILDTELGESGAVHESMSVLLDEYLQEISTPNNE
                     EQVSELFFKERLFGSSLKVSHNRNINPYGRNYSSILGNACIPGSRMFVDVDGTFHMCEK
                     ISYQFPIGNCEEGLDINAISRIVEKWSEKFTAQCKECPYQSICGLCYASCASGDNFDIQ
                     GICTTRRKDIERQLSILYSTLEQNPDAMRDFSAHKDSIDRKYDSFRFVMDKC"
     aSDomain        complement(11117..11467)
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EC604_RS08615_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="2.90E-11"
                     /identifier="RREFam021.1"
                     /label="EC604_RS08615"
                     /locus_tag="EC604_RS08615"
                     /protein_end="139"
                     /protein_start="22"
                     /score="34.4"
                     /tool="antismash"
                     /translation="IGVFETRQGNKYIFDGATNMVLSASEELAHTIESHDKLDRELIYE
                     KADLPLRQLMKKWDLFKLHEVELSQDMILDELRTYPYPQMILGLTENCNLRCKYCIFSG
                     NYEEMRTHTFKRM"
     gene            complement(11567..11752)
                     /locus_tag="EC604_RS08620"
                     /old_locus_tag="EC604_08595"
     CDS             complement(11567..11752)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_08595"
                     /product="hypothetical protein"
                     /protein_id="WP_123063756.1"
                     /transl_table=11
                     /translation="MDQQIGTNGWLCNVTCFGGCLVGCAAGCAVDGPVPISDVIGATAV
                     NATATTITSSKTSSAL"
     gene            complement(11811..11996)
                     /locus_tag="EC604_RS08625"
                     /old_locus_tag="EC604_08600"
     CDS             complement(11811..11996)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EC604_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EC604_08600"
                     /product="hypothetical protein"
                     /protein_id="WP_123063757.1"
                     /transl_table=11
                     /translation="MDQQIGTNSWLCSVTCFGGCLVGCAAGCAVDGPVPISDVIGATAV
                     NATATTVSTGATKSAL"
     misc_feature    12066..12079
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.75"
                     /tool="antismash"
     misc_feature    complement(12067..12080)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.18"
                     /tool="antismash"
     misc_feature    complement(12093..12102)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    12254..12267
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.58"
                     /tool="antismash"
     misc_feature    complement(12255..12268)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.24"
                     /tool="antismash"
     gene            complement(12387..14540)
                     /locus_tag="EC604_RS08630"
                     /old_locus_tag="EC604_08605"
     CDS             complement(12387..14540)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="EC604_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08605"
                     /product="MMPL family transporter"
                     /protein_id="WP_161556890.1"
                     /transl_table=11
                     /translation="MGYRSLATLISRYPRFIIICWVVIIGMSVAWAWKLPDMVQDHGLK
                     LARGQAQAVELILEQEFGSPPDPVVLLFNKHPNTSEIAFRTWIQERLAAVRTLPAISSV
                     VSPFDVNTQGRMLRDDQAYALVHMDIPPHRMKHPLAQLREVLEVDKQADLPGTVQLTGK
                     TVVQEDVNRLSFQDLERAEIIGIPIALIILCFAFRGLYAACIAVMMGISAVITAMGITS
                     LLGHYLELSNFIINVIPMVGMALSIDFALIILSRYREELQQRYANRGKSNVERNIHMQR
                     ELLQQTLRTAGRAVLFSAACVFLGLLGLLWIRLPMFLSVSLGATIVLVLALLLNVTLLP
                     AILCLSADRVFARITRTSGVTGQQTRDSTLEHSFWHRWSAIVMKRPVWMGLVGTTLLLC
                     CVFPVTRMDLSVPDASSLPARMESRQASEQIEQNFGQQHISWLDIIIGKKEEPLTASHW
                     ETAKHKVTKLQQDERVVSIHSQGDVSNSFIRLTVGVYGEAGSDEMKEWLRQTRTDDVTA
                     MPETIPIRYGGEAVYEDEIMHEIAQQLPKVLVFVMVSNYLVLLVAFRSLLIPLKAILMN
                     LLSLAASFGILVWVFNEGHLGMEVSSIAIMIPVFIAGLVFGISMDYGVFMLSRIQEVYR
                     QTGDSDTAVQQGLASTGRLITSAAGILLAVTVPFAFAEVEGVRQLGIGITAAVLIDVTI
                     IRLVLVPSLMKLMGRWNWWMPGQ"
     gene            complement(14721..15341)
                     /locus_tag="EC604_RS08635"
                     /old_locus_tag="EC604_08610"
     CDS             complement(14721..15341)
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688861.1"
                     /locus_tag="EC604_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08610"
                     /product="flavin reductase family protein"
                     /protein_id="WP_123063759.1"
                     /transl_table=11
                     /translation="MYSLNPEELTPKDNYKLMSGSIVPRPIAFVTTLSDHDGIINAAPF
                     SFFNVVSSDPPLLSISVGRKNGVMKDTARNVLAHNELVVHICDENIIEDVNETAALLEP
                     HESELERTRLTTVPSSVVAVPGIQEALIRMECKLYQHIPISNDAGVPVSDLLLVRIVHY
                     HFSEKVYLADKGYILMDQLKPVSRLAGNDYAKLGDRFTVIRPE"
     misc_feature    15518..15534
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.42"
                     /tool="antismash"
     gene            15596..16228
                     /locus_tag="EC604_RS08640"
                     /old_locus_tag="EC604_08615"
     CDS             15596..16228
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014368542.1"
                     /locus_tag="EC604_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08615"
                     /product="hypothetical protein"
                     /protein_id="WP_123063760.1"
                     /transl_table=11
                     /translation="MNHVYSPYAGYYDGRYTSYGEDRSIQFPPLFPGGGSLPGGQTPPG
                     IPGSPGSYPPFVPGVGTPPGPYFPGGMPGPGPGPAPGVPAQLAQGNLPSLLSAYPRPVG
                     QPPAEMLFLYNLIKSSPGLLPLFLQQQPQSLTQAVQFAQTGAAAPRDQEQRVLPNFCYN
                     RWSLVFTYNDVYLMWPAINLFGFVVGYFYPYQTPGILLNTQILFALC"
     gene            complement(16303..17538)
                     /locus_tag="EC604_RS08645"
                     /old_locus_tag="EC604_08620"
     CDS             complement(16303..17538)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688864.1"
                     /locus_tag="EC604_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08620"
                     /product="multidrug effflux MFS transporter"
                     /protein_id="WP_123063761.1"
                     /transl_table=11
                     /translation="MKSKPASLHIPATPRVRMALILGTLSAFGPLSLDMYLPALPTLAD
                     EFGSSTSYAQLSLTACMIGLALGQLLAGPLSDVRGRRIPLIAGLVLYTITSILCLVSPT
                     MGSFVVLRFIQGLAGAAGIVIARAVVRDVYEGPELTRFFSLLMLINGVAPIAAPIIGGQ
                     ILTYTSWRGVFILLSLIGALALFAVIFGLGETLPTQKRSSGGLKQTLLTFGSIARNRRF
                     MGYALTQGFAMAGMFAYISGSPFVLQKIYGVSPQMFSICFAINGLGIIFASQIAGRLAG
                     KVSETRLLIAGLLMAAVGGTSLLIAILAGGGLISVLIPLFMVVSSVGLINTASFALAMA
                     DQAKAAGSASALIGVMTFLFGGLVAPLVGLGGEHTAVPMGIVIACADLGALFLYFVMIG
                     RSKPKQTISTTP"
     gene            complement(17585..18331)
                     /locus_tag="EC604_RS08650"
                     /old_locus_tag="EC604_08625"
     CDS             complement(17585..18331)
                     /GO_process="GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688865.1"
                     /locus_tag="EC604_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08625"
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="WP_123063813.1"
                     /transl_table=11
                     /translation="MNAPHPIDQFKKFKYEITRFMMIYKFALDQMETKIEVLKEEFQSL
                     HDYSPIEHTKSRLKSPESIMNKMFRKNHELTFESIKENIKDIAGVRITCSFISDIYRIK
                     DMLCNQSDLRVLEVKDYIQNPKPNGYQSLHLLVEVPVYMSNGEERACVEIQIRTIAMDF
                     WASLEHKIFYKYNKDVPEHLTRELKNAADSANALDHQMERLHREIQEIKDAENERDEEE
                     LRRIIINNQQFTLPNNLLRLLGGGED"
     gene            18564..19289
                     /locus_tag="EC604_RS08655"
                     /old_locus_tag="EC604_08630"
     CDS             18564..19289
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016936036.1"
                     /locus_tag="EC604_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08630"
                     /product="YoaK family protein"
                     /protein_id="WP_123063814.1"
                     /transl_table=11
                     /translation="MNHNHLQKYAMLLLCMSAGMVDVIGYLGLGHVLTANMTGNIVLLG
                     IAIARAQEFVVLRSLLALIGFIAGNAIAAHMLGKTKTINGWSPRVTAVFSVESILLLLF
                     AILMISPFSEPLSYLLIVLLAVAMGMQTTVARRIGIAGISTTVLTNNLAAVIEDAVSIL
                     HRLKHANIRSLPKALSTDAYLRAGAVVIYLGGVIVAALLFHHMPLIAVWIPVLVIAGVT
                     FQARFASWGKELELHRNPE"
     gene            complement(19347..20246)
                     /locus_tag="EC604_RS08660"
                     /old_locus_tag="EC604_08635"
     CDS             complement(19347..20246)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370376.1"
                     /locus_tag="EC604_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08635"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_123063762.1"
                     /transl_table=11
                     /translation="MNLHGLRLFHAIVRYGGVTRAAEELNISQPAVSSQVKKFERELGI
                     GLFGSEGRKLVLTDAGKQLMEYAERLFMLEQEVEQFVEDMREGKKGLIRLTATYLPSNF
                     LLPRWIATFKQTHEEVELVVSTSNTQMAFDQLLRYEAEIAIYGGSGVSHPGVHWDKLFE
                     DEMWFVVHPDHPYAGQNITLHEMMAEPFIMREKGSATRERLAALCTTNNLPSPRITLQF
                     NGLNETISAVKAGYGANFISSLVVREDVNQGKLARVYVQNVQLQNTIAICTRAGEQLSP
                     AAKQLVQWIRQEALAMHS"
     misc_feature    complement(20236..20249)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.47"
                     /tool="antismash"
     gene            20421..21137
                     /locus_tag="EC604_RS08665"
                     /old_locus_tag="EC604_08640"
     CDS             20421..21137
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017688869.1"
                     /locus_tag="EC604_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EC604_08640"
                     /product="O-methyltransferase"
                     /protein_id="WP_123063763.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 2.9e-42,
                     bitscore: 138.9, seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.4e-10, bitscore: 35.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYDLNDSKVNQPARWNEVDHYINSLLIPNDKDLEAALEANAAA
                     GLPSHDVTPNQGKFLQLLLKIQGASRVLEIGTLGAYSTIWMARALPDHGRIVSLESEPK
                     HAEIAQANLTRAGLMHKVDLRVGPALTSLPDIKEEYPEPFDLIFIDADKPSNPDYLRWA
                     LRLTRPGSLIIGDNIVRDGEVIHSDSEDARVQGVRTFLECIGNHPHLEATALQTVGSKG
                     YDGFVIARVTDTPATK"
ORIGIN
        1 tcaacaagga gcgggagcaa catcacttct atccgttctt tcattttttg attgccggcg
       61 tgaacgcatc gtttctaacc ggggatctgt tcaatttgtt tgtcagcttt gaattgatgc
      121 tgatctcttc ttacgctctg attgtactcg gaggcacgga aagacagctg cgtgaaacca
      181 ttaaatatgt actgatcaat atcgtgtctt ccgccttatt cgttgcctcc atcggctttc
      241 tgtattccat tacaggtacg ctgaatatgg ccgacttgtc ggtacgcatt gctgaagtag
      301 gacagagcgg agtagtcaca ctgattgcag ttcttttcct aatcgtattc agcatcaagg
      361 caggcttgtt cctgtttttc tggttatccg ggtcttatgc ggctccgccc gccgtcgtta
      421 cggcgttatt cgctggtttg ctcaccaagg taggcctgta tgccattgtg cggacattta
      481 cgttgatctt ctatcatgat ccagacttct ttaatgctct gatcggctgg atggcgggtg
      541 ccacgatgat tctgggtgtg attggagcga tctcgtatcg tgatgtgaac aaaattttga
      601 tctataatgt cgtcgctggc gtaggtttcg tagcatttgg tatggctgcg gccagccgta
      661 gtgctctgga aggattactg ttctatatgc tgcatgacat gttgatcaaa acactgcttt
      721 tcctgctcgg cggtgctctc attgctgttg cgggaacttc aaggctcgat aacatgggcg
      781 gactaattca acgttatccc gtgctgggat ggatgttctt catcagtgcg cttgcgcttg
      841 cgggcctgcc tccgttcagt ggattcccgg gaaaattgat gctttttgag ggcggcttcg
      901 aagccggatt atacggttta actggcgttg cagttctctc tagtctactc atgctgtatt
      961 cggtactacg cattttcatt caggcgttct ggggtgagcc tcctgcaggc atggcaagac
     1021 gtccttatgc ggtgaacgga ctgctgatcc ctgccggaat tctgtttgct tttatcatcg
     1081 tcatgggcct cggggctgaa ggtatgttcc aactcacgtc ccgcgcaggt gatattctgc
     1141 tacatcccaa catttatatt gatgccgtat tgaaggagta gatgtctatg gcctttcaaa
     1201 ttgtactcaa tctgatcatt gcctttgtct ggatgttttt gaataacgcc tggaatggtg
     1261 ttggttttct cgttggattt atgcttggat tgctcctcat cggaggcatg cgacgtttct
     1321 tcccgcagcg cttctacatc gttcgagtct gggctatctt caaattgatt ggattgctgt
     1381 tcaaagaact cgttcgagca agcatcgagg tcattcgaga gattatcaaa ccgcggcttg
     1441 acattcgtcc aggtattttc acctatcgca cacagttatc ttcggattgg gaagtgacgc
     1501 tgctgtgtct gctgatctca ttgacgccag gttcactgcc acttgaaatc tcgggcaatc
     1561 agcgtaagct gttcatccat gcactggata tcaaagatga agagaaactg cgaaacgata
     1621 ttcagaatac gtttgaaaaa gcaatcatgg aggtgacacg ttaatgttat cctcactact
     1681 gtttatctca ctgctcattc tatctctagc gattctggcc tgtttgtatc gtgttcttcg
     1741 cggtccgtcc atggctgacc ggattacagc tcttgatacg atcggtatca atgtcattgc
     1801 aattgtggct gtactatcga tgatgttgca gacgcaggct tatctggaca tcattttgct
     1861 gatcggcatt ctggcttttc taagcacagt cgcatttgcg cgttatattg aacgaggggc
     1921 ggtgtttaaa aatgaaggag atcgttagta gcaccgctga aacgggaatt gggctgctgg
     1981 tgctgcttgg ggccctcctt agtgcactca gtgccttcgg actccttcgt ctccctgatg
     2041 tatatttgag agcccatgct gccaccaaaa gcatgacact cggcgtgttt tgtgtgctca
     2101 gcggtgcatt tttcttcttt tggtactttg acaactacat cagtgctcgc ctgctgctcg
     2161 gtattgtgtt tgttttcatc actgcgcctg ttgcgggaca cctgaacggc cgcgctgcct
     2221 accggaccga cgtgcctctc tgggagcaaa gtgtacaaga cgaacttgaa ccgttgttaa
     2281 aagggaaaaa gatgaatcac gaagcaaaag atatgatgga gtagtttata taaatttaat
     2341 gaatagttta cacggaacac tccaatgaca gaataacctt ccgatcgctg ttatccccgg
     2401 atttttttga ctcccttttc caaatggaaa aatccggtga taaaggcgaa cgctttgcgc
     2461 ttcttcaggt tttttctgtc ctctccgtta atgtgtaaaa gtaatttaac ttatacattg
     2521 gcgaaaataa gtaaaaaatc ccccggagat atcgctcgta agcggctttc ctccggggga
     2581 tttcttatat aacctaaata tcgtttgtat acttcgatac agatagaact tacccaccaa
     2641 actactttct tatcagaaac cgtttaaacc ttggcgtttt agatccgcag ccacgattcg
     2701 agcaagttgc gatgctcctt gccggttcgg atgcaaacta tcaccattca tgtatagagc
     2761 aagcgtagct gctggcccaa tggaagtgaa gtatgccgag ctgagcttgt tcagatctac
     2821 gagtgttact ccctcttcct gtgccagtgc acgcgtagac gcgttatacc aacggttctc
     2881 cgcctgatgc acattggacg aattaaagtc tgttgcccgc ccttgaggtg tcgagagaat
     2941 aacagttgcc cctttgtttt tcgccagacg aaccatatcc cgcatgatct ctttgaactg
     3001 agcctcagtt gtattgttct tggcgttcgt atcattaatt ccgagctgca gaataaaata
     3061 gtcacccggt ttgatatact tcagaattgc ttccatctga ccatcatcac ggaatcctct
     3121 ggcaatctgc ccactcgtgg ccatgttacg tacctggaaa gtggtgttgt ttacataaga
     3181 gggaagcaac tgcccccagc caccctgtac gctgctagca agcggataat agttgcacac
     3241 cgttgaatct ccaccaatat agatcgtacg attcgtgaca ggctggttgg acagtttgcg
     3301 aatttcaagg gcacttagcg taaaagcagt acctgctttg ccttccgtta ccagcagatt
     3361 cagctgtccg tctgtcactg gaatctggaa ttgatccgtt gcgccgttgc ccgtcatatt
     3421 catgatctga tatacccctt cggctgccac actagctctg gccgtgttac ccagcgtcac
     3481 tttgacctca tatagaccat tcggcaggtc aacattgaag gtattatcac tttttgtacc
     3541 aaatttcaga aattgaacgg catcacttgc aacaccacta ccagatgcgg aaacattttt
     3601 catattcgcc ggtgtgttga atccataacc ccttgcagct gtataagccg tcgaggcaga
     3661 cactccagta tatccgttcg ttactgctcc tgcaccgaaa tcgaatttgt aatgatccga
     3721 tgcagcctcg gccacctcaa ctctgtcagt ccctaaccca accgcgatca tacttgtagc
     3781 aagtacagta cataacatca ttcgtaaaga agttgaccat ttcatcatat aatccatgct
     3841 cctctcgaat taaaatgata ccgtttgtac ccatccgaat gcagatcatg atgaaatttt
     3901 acaatgacaa ttacaatacc tgttcaagcc aatcataagc ttttgcacca ctaatctcat
     3961 gtccaccgtc aaaataatct gcatccagtg cttgttctgc tccagcatgc ttgtaaatca
     4021 ttttcaaacg ttcgtgagcc tcccgtgccg aatgaagcgg aaatacaaga tcttcacttc
     4081 cgatctccag aaatagaggc cgcggagcaa tcagaccgat gatatccggt agctctgctt
     4141 cctgcagaat acccggaatg tagttgtcaa ggcaatgatt gcggtccaga atgctgccat
     4201 gaaacgtact tgcgtaacca ctaaccacga ccgctttgca tcgttcatcc attgcggctg
     4261 taaaggctgt aaccagcccc ccgccggaaa tgcccatgct tccgatccgc tctgaatcaa
     4321 cttcaggtcg ggtggataaa taatccaaca cacgcgttgt ttcataaacc cgatgtcctg
     4381 caagtgtctg gcctaccata agcagatgtg cagcgatttt cgtacaggaa cttgcgcccg
     4441 gcggtgcctc tcgatcctca tccagtcttc tgtccccaaa cccaagcagt tctggagcag
     4501 ccacaacgta cccacgcttc acaagcgcaa cagcaaaatc tttgtgtaat ccaggctccc
     4561 ctgcccgcgg cgaaccatcc ggttccattc cgcagatctc ccggctcccg tagccgtgtc
     4621 catgacaagc aacaatagct ggcctcttca catcggtagc gcttacatct tcgggggtta
     4681 aaagataaat tggcatccgt aaccccgtgt aggttgtgat ctcaatccgt tcccggatgt
     4741 aaccatcaca tgatgtacgt tccagcacaa cgggttgtag ttcggcagct tccgccggaa
     4801 atccgccaag tcgctcctga actctgtctc gcaattgcct agaccatgct gtaaaatcct
     4861 gatctgcatc gtaaacggag tgcccgcgaa gactggtttg ttggtacaag tagttatcaa
     4921 tatcctgcat gagctttgtg tccctcctgc ttgtcgtggg ttacattcca atggttgact
     4981 tgttttctca tattcttatc cattatagaa ctaaaagtaa aaataaggaa tctcttatgc
     5041 atataaaaaa atgaattccc atttttgatc agatgagaat tcattttatt aaactcaaaa
     5101 aataacatta atcatcgtct agacgatttt ttcaacctta aataacctca tcagaaactg
     5161 tgacacgaac gctgccacga tacagatcat tccactgtat gcaacataac gaaaatccag
     5221 aaagctgaaa tccatccgaa gatagttaac cgctggaaat gctgcgacaa tacccaccag
     5281 aatgaatatt ctgaaaattt tcagcacggc ttcacttcca tttgttgccc aaacaatagc
     5341 attggccata tacaaaaaag cagctataca caaaataatg gtcagacccg aagagaaaag
     5401 actcgtcgtc cacaccgatc taaacccaag cagagtaaag ataaaccaga ttagaacacc
     5461 attaatgata gccatagcta caacacggat tagagcaaat aaccatactg ccagcatgat
     5521 tttaccgggt tttgaaacca ccgcaagcag gaaactcaag ttcttttcag ctttctcttt
     5581 tgtgaaaaac tggagaacgt gaggaatacc gacatacaat gcaaatacca atgcagaaga
     5641 caggagacca acagcaatca atgaattggt aaacatgaca cgatgttccc gggtctcatt
     5701 caacttgtgc aacagtggaa caagaccatc gatcgtcaaa cccagacttg cttccaactc
     5761 ccccagttga ccgatcgtaa acacaaaaaa aattccaaac atcaatactt gcatggtcaa
     5821 agaccttttc caattgaggg tttgtacatc ttttcttaat aacggcagca agtacagcct
     5881 ctcccttccc caaaaagatt actttaacgt tagttttgta cagctgcttg tttggttgtt
     5941 ctgtagaagt cctctaatga gcttttttcc ttaaaaaatt cctgaatttc tatgccatgc
     6001 tgcattaaaa cttgcaacgg ctgtttaata acctccgatt caaccatgaa tgtcacagac
     6061 tgctcagtat gattcaccac cgtaattcct tcaataccct gaagaatact caccaccaat
     6121 tgtgagttgt cacaggtaac aatgtaacgt tcgctgattc cagtgatagt ctgaagtgct
     6181 tgatctgcta caattcggcc ttggtgtatc ataataacct gatctgcgat cttctctaaa
     6241 tcaaacaaat catgagaact gatgagaatc gaagtgcccc gatcggaaca gatttcgctg
     6301 agtttgtctc ttaaaaaaat tttggagtct ggatcaaggc cgttaaaggg ctcgtctaga
     6361 ataagcaact caggctcgtg tactaattca cgtataatca taagtttttg tttcatacct
     6421 ttggaaaaac gtccgacctt taaagaagtc tttaattcga aatgttgtac aagtctgttg
     6481 tagcgttctg caattttatc tttttccatt ccgcgcaggc tcgcaaaaaa aaggacgttc
     6541 tcccaggccg acatttcact atacagccct ccctcgtcaa acacgatacc aaatcggttc
     6601 ctgttcttct gactcatgtt atacgccggc tcgccaaaaa tggaacatcc ccctgttgta
     6661 ggagggtaaa gtcctgtaat gcagcgaatc gttgacgttt tgcccgctcc gttctccccg
     6721 atcaaagcgc agatttgccc ggagtgcgta gtgatgtcaa tatttttgag cacatggctt
     6781 ccctgtaggt tcagatttaa tccacgtgtt tcaataatct gagatcccat aatttccccc
     6841 ctctaaggat gatcactaac ggtcttcatt tttcatataa aactgctgcc caccatcttc
     6901 tctggatgat tcaccaagat ttaaaggttt gcctaaatag aacaaatcgg gatcatggga
     6961 gatgacaacc agaatcttat agaacgcttc attctctatc atttgaataa ctctgctctt
     7021 catgatagca tccatgttcg ctgttggttc atctaaaatc accatttctt tatttgcgag
     7081 caccgttctt aaaaaagcaa tcatttgtct ctgaccacct gaaaggttag ctcctccgtg
     7141 ggcgatttcc gtatccaatt catttggaaa atcggagata aatggttgaa gctgatactt
     7201 ctccagcaat gctctcagat gaactagttg ttccggctga gcattcggaa gtatgttgtc
     7261 cagaatcgta ccctgaaaca aataggtctt ctgtgatatg taggaaactc ttctgcgcag
     7321 atcagatagc ttaagacatg atatatccat gccattataa aggatcgttc ccttattcac
     7381 agggtaaaga cctagaagca atttaacaaa ggtggttttg cccgagccat tggctccatt
     7441 caaaataacg atatcacctg taaacaggtt gacattaagc tgatccagca cagatcgctt
     7501 ttcaattccg gaaatatatg cataggagat attatggatg ttaaccgaat gaataggttc
     7561 ggagagaacc atccgtcttc caaactcctc atccttatta tccatatact cccttactct
     7621 atcaatacta accattatag gatttatagt tactccaaag gtagccacag cctggacatt
     7681 tcccagtact tttgcaaggt aacctgtgaa agatacatat tcacctaaag ttagcgtttt
     7741 ccccaaaatc atgattccgg agaacagtaa tactatagct ccggataagg aactgagaag
     7801 tgaagaactt tccatgtatc cgttaatgtt tctgttctgt ttcagaatcg cagtaatgac
     7861 ctgatccgtt ttggtataaa tccgtgatat gtagcgctgc ttggccccct gaactttaat
     7921 ttcctcaatt ccgttaaggg tctcaaacat aactcccgcc atctcagctg agctttcact
     7981 gacttttctt gtgctatcac tcatccgtcg actgtaccag acagtaacaa caacatatag
     8041 aggaataatg gccagaacaa taagcgatag cttccaatgg attcgcacga gcaaaataac
     8101 cgagatcaca ccgtccaata ccccaatgag aatgttaatt acagatggag aaaaaagact
     8161 ccctatactt ccactctctg aaatccttga catcagataa cctttatcat gtttgtcgat
     8221 gaactccata ggcatatcta ccgtatgtcc aatcatcttc attcgaagca cattcgaagc
     8281 acgagttccc gccttgacaa tatagtattt acctataaga gagagaacgt atcttatgac
     8341 atgaagacag ataataatga tgacctgttg atagagaaaa tgcgtagttc cctgtggtga
     8401 agaaagatta tcgataattt tgcctgtaat aagcggaatt ggcatcgcaa ttagggatac
     8461 cattgccaaa gctccaaaag agagtaccag aagcaacctg ctgccctcaa gatacggcct
     8521 gaggtacata aggttgctaa acattttttt catcattaat ttttgaacat gccaataatc
     8581 ataaatgttg caatatacag gacaaaaacg atggccagaa tcatgctcat cctgcttttg
     8641 ttcttgacct tcctgttcag aaagaccgtc agtataccta tggccacaat acttaaaacc
     8701 ataattatat tgttcatacc aagctctcct ttaaagcttg tttacaatac accttggagg
     8761 ataatgatcc acctgcacta ctctcgatcg cccggcaatc cgagcatgca taccgcgagc
     8821 tacagctccg gcaagaatct actctatcca gcgtatacgt ccaatactcc tggtagtctc
     8881 gttgatcagc aatccgtttg aaagagtctt tcaacacatt cccgatcgtt tcatttctca
     8941 tcatgggaca caccgataca tcgccgtttc gaaatacgga caacttgcca ttcaaacaag
     9001 gatgaaagtc gacgttatga aaaaaactga gatctgtaaa acagctttga gcgcccttgt
     9061 cgctaaataa gagctcgtta tacaccgggt catcaccaat ttcatgaata aaactgagct
     9121 gcatacccaa tggattgaaa tgtttatagt agtctacaat ctcctctcga aatatatagt
     9181 tcattttatt caatactaca ttaaaataga aggaaattcc tgtttttttc aatttattca
     9241 tattttcgta gaaatttgag aagtcaggat gattttctat catacgattg gttaaatcct
     9301 gattatggga agacgtatgg ataaccaagc tgacaccaga taactcttcc cagttcagct
     9361 ctcctgtgtc cattaaattc gtatagataa agatgttact gtaaccgagt tgacgcgcct
     9421 cagcgaggat taccgagaga agttcccact tcaacaaagg ctctccacca atgatatgca
     9481 atgatctgca tcccatctta tggctctgct gcaatacgat acgataatcc ttctcctcca
     9541 taagattatc ttgactaaac ccgccataac gtttacaccc ggtcattcgg tgcaccatac
     9601 tatccgtatt gcaaaaactg cactccagat tacattcatc gttaatgttg agatacagat
     9661 tagatattct tactctattc ttggcaaaat ctcgaatgga tggcggaagg ccaaaacgaa
     9721 ccttttcgat ataggcgtta tgggaatagt agctgcccat gccttgctct ataagctgag
     9781 agagcaggat gtaatttatg ttgtctacct cttcgacagg tacgccccta ttcaattcaa
     9841 gcagcattga tgcgtctgct ggtgatatcc tcaacatatt attttcactc aaatcatata
     9901 atgaagcttg acgctccccc tgtacaatgt aacaatgtga cccggtttta aaatacacat
     9961 tagacacctc catttgtatg tccctttgct agaaacgacc tcagcattta tccataacaa
    10021 aacgaaacga atcatactta cggtcgatac tgtctttatg tgctgaaaaa tcacgcatag
    10081 catctggatt ctgctcgaga gtgctgtata agatagacaa ctgtctctca atatcctttc
    10141 ttcgtgtagt acagatacct tgtatatcga aattatctcc tgaagcgcag ctggcgtaac
    10201 atagtccaca aatcgattga taggggcatt ctttacattg tgctgtaaat ttttcgctcc
    10261 acttttcaac gattcgactg atcgcgttaa tatccagacc ttcttcacag tttccaatcg
    10321 ggaattgata acttatcttc tcacacatat gaaaggtacc gtccacgtct acgaacattc
    10381 gactccccgg gatacaggcg ttaccaagga ttgaagagta gtttctgcca tatgggttaa
    10441 tgttacggtt atggctcact ttaagactgg agccaaagag tctctctttg aagaatagct
    10501 cggaaacctg ctcctcgtta tttggtgtac tgatttcctg aaggtattca tcgagcagca
    10561 cagacatact ctcatgaaca gctccactct cacctaattc agtatccaaa attttggata
    10621 gtcttccgcc catcgatttc aagagatgtt tttcacgtac gaaaaaatcg ttcatcgcaa
    10681 ccatatcggt ttcattttca taacagctaa gtatcatcat agggagaatc tgttccttcc
    10741 cctgtctctt tatttctgcg agcaacttac gaatattccc atagacaaca tcaaacgttc
    10801 cctgctcatt tacaaaaact ctatttttat catgcatttc cttcgaaccg tctaaactga
    10861 ctgatatcat gacgttatgc gtgactaaaa attcaataat gcgatctgta agtaatgttc
    10921 cgtttgtcgt catagaaaac atggtcttga aacccgtttg ctttacatag gcgacaactt
    10981 cttgaatgag atcaaatctg agcagcggtt ccccgccata gaatgaaata acaggctgtt
    11041 tatccggagc atacgctctc cattcctcaa tataatcgat atacttttgt acgcttttta
    11101 acgcagtctc tttctccata cgtttaaatg tatgtgttct catttcttca taatttccgg
    11161 agaaaatgca gtacttacac ctcaaattac aattctccgt aagtccaagg atcatctgcg
    11221 gataaggata ggtcctaagc tcatccaaaa tcatatcttg gctcagttcc acctcatgca
    11281 atttgaaaag atcccacttc ttcatgagtt gcctcaacgg taaatctgct ttttcatata
    11341 taagttctct gtccagtttg tcgtgactct caatcgtatg agccagctct tcgcttgcgg
    11401 aaagaaccat attcgtcgca ccatcgaaaa tgtatttgtt tccctgcctg gtttcaaata
    11461 cacctatatt attcattatg caacccacct taacttggat taaaaatgta ctaaagagga
    11521 catcccgcac cacgtgttcg gaatgccccc accaacagct cagaacttaa agtgcagagc
    11581 ttgtcttact tgaagtaata gttgtggctg ttgcgttgac agcggtcgca cctatgacat
    11641 cggagatcgg cacaggtcca tctactgcac atcctgcagc acagcctact agacatccac
    11701 caaagcaagt tacgttgcag agccagccat ttgtaccaat ttgttgatcc atatttactt
    11761 cctcctagat ttaattaaat ggttaagatt tcaatttata tacatttact ctataatgct
    11821 gacttggtag ctcctgtaga aaccgttgtt gctgttgcat taactgccgt tgcaccaatc
    11881 acatccgaga tcggcaccgg tccatccact gcacatcctg ctgcacaacc caccaaacaa
    11941 cctccgaagc aagtaacact gcacaaccaa ctgtttgtac caatttgttg atccatgttt
    12001 tttcctcctc ataaattgtt tttggaaaaa ttaaagtatc ctacaaaaaa ccaaccacag
    12061 cctccttttt tgaataaaat tagatatatt gatcaaaaaa tatttaatac aaccaaataa
    12121 tagaatattt actatgagag ttatataata taagtcactt tcactctaaa tttgacaatt
    12181 tttttcttct gaacgatatt attgagacta tacttcagtt gaatacaaag tttactttaa
    12241 aaagtgggcg ttgattttaa taaaaaaaag atactccctc ccctgattca ggcttcggaa
    12301 tatcctttat gtgttgtcgt gaaattttca tatccgtttt atacttacaa gcgattttct
    12361 tcaaattttc ttctaagctt ttattgttat tgaccaggca tccaccagtt ccatctcccc
    12421 atcaatttca tcaaggacgg gacaagcaca agccgaatga ttgttacatc aataagcacg
    12481 gctgccgtga tgccgatgcc caattgcctt accccttcga cctcggcaaa agcaaaagga
    12541 accgttaccg ccagcaaaat acctgctgca gacgtaatta aacgccctgt tgaagccaag
    12601 ccttgttgaa ccgctgtgtc actgtcccct gtttgtctgt acacttcctg tatccggctc
    12661 aacataaaaa caccgtagtc catcgatatg ccgaatacca gcccagcaat aaataccgga
    12721 atcatgatgg cgattgatga tacttccatt cccagatgac cctcgttaaa gacccataca
    12781 agtatgccaa acgaagcggc cagactaagc aagttcatca gaatcgcttt tagtggtatt
    12841 agtagagaac ggaatgccac tagcagcacc agataattgc ttaccatgac aaataccagt
    12901 actttgggca gttgctgggc aatttcatgc ataatctcat cctcataaac tgcttcacca
    12961 ccataacgaa tcggaatggt ctctggcata gctgttacat catctgtcct tgtctgccgc
    13021 aaccattctt tcatctcatc tgaacccgct tccccgtata caccaaccgt taatcggata
    13081 aaagaattcg aaacgtctcc ttgggagtgg atactcacca ctctttcatc ctgttgaagc
    13141 ttggttactt tgtgtttggc cgtctcccag tgagaggctg ttaacggctc ctcctttttc
    13201 ccgatgataa tatcaagcca agaaatatgc tgctgaccga aattttgctc gatctgctca
    13261 gatgcttgac gggactccat tctggcaggt aaggaagaag catcgggtac ggacaaatcc
    13321 atccttgtaa cgggaaacac gcaacacagc aatagtgtcg tacctacgag tcccatccat
    13381 acaggacgtt tcatgacgat cgctgaccag cggtgccaga agctgtgttc aagtgtgcta
    13441 tcccttgttt gttgtcctgt aactccggat gtgcgtgtta tgcgagcaaa tactcggtct
    13501 gcacttaggc aaagaatagc aggtaacaag gttacgttta acaacaacgc cagcacaaga
    13561 acaatggtag ctccaagcga cacactgaga aacataggca gcctgatcca gagcagaccc
    13621 agcaaaccca gaaacacaca tgctgctgaa aacagcacgg cgcggccagc tgtgcgtaat
    13681 gtctgttgca aaagttcacg ttgcatgtgg atgttacgct cgacgttgga cttgcctcta
    13741 tttgcgtaac gctgctgtag ttcctccctg tatctgctta aaatgatcag tgcaaaatca
    13801 atactgagcg ccattccgac cattggaatc acgttaataa taaagttgga taactccaga
    13861 taatgaccca gcaaagacgt tatgcccatc gccgtaatca ctgcactgat ccccatcatg
    13921 acagcaatac atgccgcata cagtcctctg aatgcaaagc aaagaatgat taatgcgatc
    13981 ggtatcccta tgatctctgc tcgttctaaa tcctgaaagc tcagtcgatt tacatcctct
    14041 tgcacaacgg ttttccctgt aagttgcacg gttccaggca gatcagcttg cttgtccact
    14101 tcaagaacct cgcgtaattg agctagtgga tgcttcatcc ggtgaggcgg gatgtccatg
    14161 tgtaccagag cgtaagcctg atcatcacgc agcattcttc cctgtgtgtt cacatcaaaa
    14221 ggggaaacta ctgacgatat cgctggcaag gtgcggactg cggcaagccg ttcctgaatc
    14281 cacgttctga aggcgatctc agaagtattc ggatgtttat taaaaagtaa cacgaccgga
    14341 tcaggcgggg agccaaattc ctgctccaat atcagttcta cggcctgggc ttgtccccga
    14401 gccagcttta acccgtgatc ctgaaccatg tcaggcagct tccacgccca ggcgactgac
    14461 atcccgatga taactaccca gcagatgata ataaaccgcg gatatcgact gatgagagta
    14521 gccaaacttc gatatcccat acccaggctc ctctgcatat aaattggatt ttaattatga
    14581 ttaacaccat gagatatgct tgatgtagta caagtctatt catgatcaaa catgattatg
    14641 ttcctaatga aataaagaca aatagcctca tgtatatgct acatggggct gtctgtcctc
    14701 actgttcatt tcacagctgt ttattcgggt cgaatgacag tgaatcgatc accaagtttg
    14761 gcataatcat tacctgccag acggctgacc ggttttaact gatccatcaa gatataacct
    14821 ttatccgcaa gatagacctt ttcgctaaaa tgataatgca caatgcgcac gagaagcagg
    14881 tcacttacag gcacgcctgc atcattcgag atcggaatat gctgatacag tttgcactcc
    14941 atccgaatca aggcttcctg aattccgggt acagcgacca cggaactggg tacagttgtc
    15001 agacgagttc tttccaattc actttcatgc ggttccagta aagccgccgt ttcattgacg
    15061 tcttcaataa tattttcgtc acaaatgtgc acaaccagtt cattatgtgc gaggacattg
    15121 cgtgccgtgt ccttcattac accattttta cgtccaaccg agatggataa cagtggcgga
    15181 tccgagctca cgacattgaa aaagctaaac ggcgctgcat taatgattcc atcatgatct
    15241 gagagcgtgg tcacaaaggc aatcgggcgg ggcacgatcg aaccgctcat taatttataa
    15301 ttatctttag gcgtaagttc ttccggattt agtgaataca tatgtaagtc ccctctccta
    15361 ctcgcatgca tgaggctgat cctcatcttc ttaatcctct actttcttca tcgttattat
    15421 atatgcatac tgtccataaa aacaaaaaaa tacttgtata gacttgccgg caatcatgaa
    15481 tgtcccatct ttactgctca tgtttagaaa tacacacttg ttaaacaatc acatctaggc
    15541 gaataccgtc atagactgtt ttcagaataa gatgacagga aggatgttct ggaacatgaa
    15601 ccatgtttat tccccttatg caggttatta tgatggtcgt tatacaagtt acggagaaga
    15661 tcgttccatt caattccctc cactcttccc gggtggaggc agtctccctg gagggcaaac
    15721 tccgccaggc attcccggaa gcccaggctc ctatcctcct ttcgttcccg gtgtaggtac
    15781 ccctccgggt ccctatttcc ctggcggcat gccgggtcct ggtccgggcc cagctccagg
    15841 tgtacccgca cagctagctc agggaaatct tccttccttg ctaagtgcct atcctcgccc
    15901 ggttggtcag ccgccagcgg agatgttatt tttgtataac cttatcaaaa gcagtcctgg
    15961 tctactgcca ctcttcctcc agcagcaacc gcaaagcttg acacaagccg ttcaatttgc
    16021 acagacaggt gcagccgcgc cacgcgacca agagcagcgt gtactcccta acttctgtta
    16081 taaccgctgg tcgctcgttt ttacgtataa tgatgtgtat ttaatgtggc ctgccattaa
    16141 tctgttcggc ttcgttgtcg gctatttcta tccatatcaa acaccaggaa ttctgctcaa
    16201 cacccaaata ttattcgccc tttgttagtg gcagacaaac tgaaacggcc cgcattggaa
    16261 gactatgctt ccctgcgggc cgttcctggt tataccaaag cactatggag ttgtagaaat
    16321 ggtctgtttc ggtttgcttc taccgatcat gacaaaatac aagaacaatg cccccagatc
    16381 agcacatgca atcacaattc ccatgggtac agccgtatgt tctcctccaa gaccaacaag
    16441 gggagctacg agtccaccga acagaaaggt cataacacca atcaacgccg atgcacttcc
    16501 agcagctttc gcctgatccg ccatagccag cgcgaacgat gctgtattaa tcaaccccac
    16561 actggacacg accataaata gggggattag aactgaaatc agcccgcctc cagcaaggat
    16621 cgcaataagt aaagaagttc ctccgacagc cgccataagt aatccggcga ttagcagccg
    16681 tgtctccgat accttaccgg caagccgacc tgcaatctgg ctggcaaaaa taatgcctaa
    16741 tccgttaatg gcaaaacata tactgaacat ttgaggggat actccgtata ttttctgaag
    16801 aacaaatggt gatcccgata tgtaagcgaa catgcctgcc attgcgaaac cttgtgttag
    16861 agcataaccc ataaaacggc gattcctcgc tatgctgcca aacgtcagca acgtctgctt
    16921 aagccccccg ctcgatcttt tttgtgtcgg aagcgtctcc cccaaaccaa agatgaccgc
    16981 gaaaagcgcg agcgcaccga taagacttag caaaataaaa acgcctcgcc atgaagtata
    17041 cgtaaggatt tgtccaccta taattggtgc tgcaataggt gccactccat taataagcat
    17101 taacaaagaa aagaaccggg ttagttctgg cccctcgtat acgtccctca ccaccgctcg
    17161 cgcgatgacg atccccgccg ctccggccaa tccttgaata aaacgtaaca caacaaacga
    17221 gcccatcgtt gggctgacaa ggcataatat cgacgtaatc gtatatagca caagtcctgc
    17281 aatcagcggt atgcggcgac ctctcacatc gcttaatggt cccgcaagca gctggcccag
    17341 cgcaagccca atcatacatg ctgtcaggct tagctgagcg tacgaagtgg acgagccgaa
    17401 ttcatccgcc agcgttggca gggctggcag atacatatcc agagacagcg gtccgaaggc
    17461 ggatagcgtc ccaagaatta gcgccattct cactcgcggc gtagcaggga tgtgtaatga
    17521 cgcaggttta cttttcatcc aaaaacattt cctttgcctt cagattgtgc tctagtgccc
    17581 attcttagtc ctctccgcct ccaagcaatc ttagcaagtt gttcggtaag gtaaactgct
    17641 ggttattaat aataatgcgg cgtagctcct cttcatcccg ctcgttctcg gcgtctttga
    17701 tctcctggat ctcacggtgc aagcgttcca tttggtgatc caatgcgttg gcagaatccg
    17761 ccgcattctt caattctctt gtcaaatgtt ccggaacatc tttgttgtat ttataaaaga
    17821 ttttatgttc cagactcgcc cagaaatcca tcgcgatcgt acgaatctga atttccacac
    17881 aggcacgttc ctcaccattg gacatatata ccggaacttc aacaagcaga tgcaaactct
    17941 gatacccgtt cggtttcgga ttttggatgt aatccttcac ttcgagaaca cgcaagtcac
    18001 tttggttgca aagcatatcc ttaattcgat aaatatcaga aatgaacgaa catgtaatac
    18061 gcacaccggc aatatcttta atattctcct tgatgctttc aaacgtcagc tcgtgatttt
    18121 tacggaacat tttattcata atgctctcgg gagacttcaa tctcgacttg gtatgctcaa
    18181 tcggactata gtcatgaagg gactggaact cttcttttag cacttcaatc ttagtttcca
    18241 tctgatccaa cgcaaattta taaatcatca taaatcgtgt aatttcgtat ttgaatttct
    18301 tgaactggtc aatcggatgc ggagcattca tcatcagttt cttcctttct tttgacacct
    18361 ctatgatttg ataaccaaca tgtatacgtt cgtacgaacg ctggtcttat gacatgtctt
    18421 ctataacatt ataaaacatc tgacatgaat aaacgaatat tagaaatgta cgtgtgccgc
    18481 tttggttcag atttcgtttt gaagaaggcg gtacaatagc tgtatactgg agaagttatg
    18541 tttgcttgaa aggacgggaa aatatgaatc acaatcacct ccagaaatac gccatgttac
    18601 tgctctgcat gtccgccggt atggtcgatg tcatcggata tctagggctt ggacatgtac
    18661 tcacagccaa tatgacagga aatattgtac tgctaggcat cgcgattgcc cgtgctcagg
    18721 aatttgtcgt actgcgttct ttgcttgccc tcatcgggtt tattgcgggg aatgcaatcg
    18781 cggcacatat gcttggaaag accaaaacca taaatggctg gtccccgcgt gttactgccg
    18841 tattctccgt tgaaagcata ctgcttctgc tgtttgcaat ccttatgatc agtccctttt
    18901 ccgagccatt atcttatctg ttaattgtac tgcttgcggt cgccatgggg atgcaaacaa
    18961 cggttgcccg aagaattggt attgcgggaa tctctacaac ggtgctcacc aataatctgg
    19021 cagccgtgat tgaagatgct gtaagcatcc ttcatcggtt aaaacatgcc aatatccgct
    19081 ccttgcccaa agcactgtcc actgacgcct acctgcgagc aggtgccgtt gtgatctatc
    19141 tcggcggggt catcgtcgca gcattgcttt tccatcatat gcctctaata gcggtctgga
    19201 ttcctgtact ggtcatcgcc ggtgttacat ttcaagcaag attcgcgtct tgggggaaag
    19261 agctggagct acatcgtaat cctgagtgag aggacatctt gcgattatgt gctgctgaaa
    19321 cacgttcaca atattgaaca atttattcaa gaatgcatgg caagtgcttc ttgcctgatc
    19381 cattgaacca attgttttgc cgctggcgac aactgttctc ctgcccgtgt acagatggca
    19441 atcgtattct gtaactgtac gttttgtaca tatacacggg caagtttgcc ttgattaacg
    19501 tcctctctta caacaaggga tgagatgaaa ttggcaccat atcctgcctt tactgcacta
    19561 atcgtttcgt tcaatccgtt gaactgaagt gttattcgtg gagagggcag gttattggtc
    19621 gtacacaagg cagccagtcg ttctcttgtc gcactgcctt tctcacgcat aatgaatggc
    19681 tcagccatca tctcgtgcaa tgtaatgttt tgacctgcat acggatgatc cggatgcacc
    19741 acaaaccaca tttcatcctc gaataactta tcccaatgca cacccggatg actgactcca
    19801 cttcctccgt atatcgcaat ctcggcttca taacgaagca actggtcaaa agccatctgt
    19861 gtattgcttg tgcttacgac aagctcgacc tcctcatgtg tctgcttaaa cgtggcaatc
    19921 caacgcggca gcaaaaaatt ggacggcaga taagtcgcgg taaggcgaat cagtcctttt
    19981 ttcccctccc tcatgtcctc tacaaattgt tccacttcct gttccagcat gaacaaacgc
    20041 tcggcatatt ccattaattg ttttcctgca tctgtgagta caagctttcg cccttcggaa
    20101 ccgaacagcc ctatgcctag ttcacgctca aactttttta cctgagaaga taccgctggt
    20161 tgactgatat tcaattcttc cgcagcccgg gtaactccgc cgtacctcac aatggcgtga
    20221 aacagtcgta atccatgcaa gttcatacat tttcgcctct tccttgctta ctggaatatt
    20281 gatccagaat tttaaccatc atattgtata acttatttat atattaacat acaaaatata
    20341 tattttattt atacgttaac cacctctata gttgaattat aagaaatatt aattcagcaa
    20401 catagaaagg aagatgtgta atgagtaagt atgatttgaa cgatagcaag gttaaccagc
    20461 cggcccgttg gaatgaggtc gatcattata tcaacagcct tcttattcca aacgacaaag
    20521 acttggaagc tgcacttgaa gccaatgctg cagcaggact accgtcacat gatgtcacac
    20581 cgaatcaagg aaagttcctt cagctattgc tgaaaataca gggggcctcg cgcgtactgg
    20641 agattggaac tctaggtgca tacagcacca tctggatggc cagagctctg ccagaccatg
    20701 gacgaatcgt ttcgctggag tcagaaccta aacatgcgga aattgcacaa gccaatctga
    20761 cccgagctgg actaatgcac aaagtagatc ttcgagtagg cccggcacta acctccctcc
    20821 ccgatataaa ggaagagtac cctgaaccct ttgatctgat tttcatcgat gctgataaac
    20881 cgagtaatcc ggattacctg agatgggctt tacgtctgac acgaccagga agcttgatca
    20941 tcggagataa tattgtcagg gatggggaag tcattcactc cgacagtgaa gacgcaagag
    21001 ttcaaggggt tcgaaccttt ctcgaatgca tcggaaatca cccccatctt gaagccacgg
    21061 cactacaaac cgtaggcagt aaaggatacg acggatttgt gattgctcgt gtcacagata
    21121 cccctgcaac aaaataaaca gtggtcaatt cttccgaaaa tctgcctttc ctgttacact
    21181 ggtatcactg cacaggcaga ctggagggag ttacttgaga gctttacgac agattcatgt
    21241 tgaaattggc gggtggtctc gcaatattca actgttcttt ctggcaagtc tgctgtatca
    21301 gatcggaaac ggcatgttct cggttcttta taatctgtac attcaaggct taggttacga
    21361 tgacaccatg aatggccaaa ttgtcagtat ccaatctctt gctacagcaa ttatgttcat
    21421 tcctattgga tttagcggtg acaagttcag ccgcaaaaaa ctgttgatta tcggggcgct
    21481 attcagcggt gcttttctaa tcggacgatc cttcgattat gccgcgagcg ggt
//
