LOCUS       NZ_CP023865            22416 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8104947
            Orig. end                         :: 8127363
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22416
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="26"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..22416
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22416
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12416](-)"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12416)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     gene            295..1629
                     /locus_tag="ACTEI_RS35760"
     CDS             295..1629
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012575.4"
                     /locus_tag="ACTEI_RS35760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_164466245.1"
                     /transl_table=11
                     /translation="MLSPEKNRMLTQVGAGTPMGELLRRYWHPIAPAMELRERRVKPIR
                     LLGEDLVLFRKPSGGHGLLSRHCPHRLTDLSLGWVDGDLMRCAYHGWGFDSDGRCVEQP
                     FEEAGPAGGFHDKAGVKSYPTATLAGLVWAYLGPGPAPLLPDFETFSWEHGFVELILTE
                     LPCNWFQCHENGMDPVHFEWLHSNGNAVRLNPEAPLYAPRHTEIDFLEFEHGFVNGREV
                     ETENAPEGPFARSSSTAEGGILCLWPYTLASGNTVEFRVPVDDHRTLNITWQYSVLPDD
                     VRTGVPESEEVPYWYGPLTEPGSDRIITSHTGNQDFAVWIGQGTVTDRSAERLGRSDKG
                     ITLLRRRYLEAIEQVARGEDPPGTVRDPAANVRIPLPLPRKFIYTEGVPRVVFEEKLAA
                     RKKSGLYGIGGFLAVQAGRPDHIQTMYEKAAGITDGSALGSGGAG"
     misc_feature    complement(1776..1792)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            1870..2385
                     /locus_tag="ACTEI_RS38835"
     CDS             1870..2385
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS38835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_170206147.1"
                     /transl_table=11
                     /translation="MVSQGQFALVPGQQSGFPLLGQRLAPAVAERPGKPGERGGATPQT
                     ERGPEPCGVRAVVAGAAGGGEIGELQGVDGRPRDVQRVAAAGADDQPGVQTLAQPQDVV
                     GDHRHRAGRRPFPEQPVDQLIRADRGAGAQRERRQHRRLLGRHPRHPGRRGALAQDRRG
                     TEKYEPEH"
     gene            complement(2437..3687)
                     /locus_tag="ACTEI_RS35770"
     CDS             complement(2437..3687)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013188.4"
                     /locus_tag="ACTEI_RS35770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation:proton antiporter"
                     /protein_id="WP_122981681.1"
                     /transl_table=11
                     /translation="MDSNTIVILLLDLALIAILARAAGALARRFGQPAVIGEVVMGILL
                     GPTVLHGVVAETLFPGQVRGYLIAFANVGIALFMFVTGLEFRRGDGHAPRRAAIGIGLG
                     SIVLPFAMGTSLGAWWDTATPDATPLGAHLFMGLALSVTAFPVLARILDDRGMTRQPLG
                     RLALAGAAFCDLLAWVLLAGVLALGAGGHQPWRLLWLLPYVAVMAACTVLLRRLVQRRA
                     GRLNPVVALAGLLASAASTEWMGLHFVLGAFLFGIVLSGLRGPAGERALKPVRESAEGL
                     GLGLLMPVYFVVAGWQVDLSVLRATQLVQLLVLLAIAVVGKVAGTMVAARVSGLRPREA
                     AILGALMNTRGLTELIVLTAGRQAGLLNDSSYSLLVAMAVLTTLSTGPILNRLQGRPKR
                     AGSASDDTTRESRLQQV"
     gene            complement(3766..4542)
                     /locus_tag="ACTEI_RS35775"
     CDS             complement(3766..4542)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS35775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ArpA protein"
                     /protein_id="WP_122981682.1"
                     /transl_table=11
                     /translation="MNVEQIDENLAKFLAERYTPESVAQLADRFHRFGFVKFDAANRLV
                     PDELQTAVREECDLLIEQHKERRNLLLSTTGNTPRRMSVVKSEEIEKSELISTLSRSEV
                     LLGFLAGITREEIIPEVSSDERYLITHQEFKSDTHGWHWGDYSFALIWALRMPPIEHGG
                     MLQAVPHTHWDKSNPRINQTLCEREINTHGLESGDLYLLRTDTTLHRTVPLSEDSTRTI
                     LNMTWAAKRDLEKDLVGNDRWWENPEAEAARAVDNA"
     gene            complement(4556..5797)
                     /locus_tag="ACTEI_RS35780"
     CDS             complement(4556..5797)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="ACTEI_RS35780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_122981683.1"
                     /transl_table=11
                     /translation="MPPPETQAARPGRRKRLRLPAGYRELLAVPGVSRMLIAALVSKLP
                     VTMVSLSLLLYLGPRYSYATGGLAVSCMAIGQGLSAPIRGRLMDRYPYRLILVVCLLFY
                     VVALGSLTAVAADRGPAPLVLALAAVSGVTAPPVGIIMRTLWRVLAGEQRLVTAMALDA
                     ATSDVVQITGPALAAWLCLSVSGEVAFGLYGALTMVAVLLVLSFPNVPPPVRRRGGGHW
                     AGPLRSAPLRRVLIANAAFSAMITAIDVVISVLNAERGTTGYIGIQIGALSVGSIVGSL
                     ALGAVPGLLARGPKLSVLIGVFASGVVLLAVTSQMSALAMTLACPITGLAYGSTFGALF
                     TAGGDLAPEGTAAETQAWLSSLTQAGAAVGAWAATEVGNVTALCAIPVIAVLSAVLTWN
                     VRGPRPAGDLPTTS"
     gene            complement(5784..7034)
                     /locus_tag="ACTEI_RS35785"
     CDS             complement(5784..7034)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014298.4"
                     /locus_tag="ACTEI_RS35785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_122981684.1"
                     /sec_met_domain="ATP-grasp (E-value: 3.3e-08, bitscore:
                     32.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.8e-06, bitscore:
                     26.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 6.2e-06,
                     bitscore: 24.6, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRKPAVLLIDPVKTGEGYKKAARDFGLHVVSLYTVEPTELNSR
                     WPEHTRDDDASLYASTAPDVLAALADTDFEVKAVVPAMESAVHLTDVLAHELGLAGNDV
                     ELAWARRNKAAMRSHASQAGVRIPAFRLVHDMAEVPAAAEEIGFPVIVKPTMGAGSHGV
                     TLVRDAEEAKSLRIPEENDLFGWPVREWLVEQYVRGREFAVNCFSSDGQHRVMDMWEYR
                     QPDDRDYDFPLWNNVQATRDDPDWARVEEYVHQVLTAFGVRRGPSHTEVKCTPDGVYLM
                     EIGARLPGGPATDQWADYTAIRPFHDALTCYLGRRPAIMDQDLDVRAMFGAIAIRNDDA
                     PGTLVAVHGLAELESHPSVDKVLVSYRPGDHVPVTRDTKTIPVGAWVSGPDQDAVVRAL
                     AEIRALVSLEIAFDASA"
     misc_feature    complement(7068..7082)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            complement(7086..8093)
                     /locus_tag="ACTEI_RS35790"
     CDS             complement(7086..8093)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2OG-FeII_Oxy"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621046.1"
                     /locus_tag="ACTEI_RS35790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein"
                     /protein_id="WP_122981685.1"
                     /sec_met_domain="2OG-FeII_Oxy (E-value: 5.2e-19, bitscore:
                     67.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELFPVIDLRDAERGPQARAEFLDRLRSAVHDIGFFQLVGHGVT
                     GGDALLELARRFFALPEPERAALSILNSPHFRGYSEIGRELTQGIPDQRRQLDIGPERP
                     SVAPGPGEPAYRWLAGPNQWPPAMPELADAVHRWTGELTGVAHRLLGLILESLEVPADF
                     LDDVVTPDPHVHFKLLHYPGPEHGETGDGDQGVGIHKDYGILTLLLQDDKGGLQVAVED
                     GVFADVPVVPGAFVVNLGELLEVATRGYLRATTHRVVRPAPGVDRYSAPFFYNPRLDAS
                     MQPLPGPYVEAAGGVVPDPANPLFAGYGENVMKGMIRAFPQVIERHHPELLPTA"
     gene            complement(8153..9463)
                     /locus_tag="ACTEI_RS35795"
     CDS             complement(8153..9463)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082212.1"
                     /locus_tag="ACTEI_RS35795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methylaspartate mutase"
                     /protein_id="WP_122981686.1"
                     /transl_table=11
                     /translation="MSGTLPRPAGNDFSDFVHERSRAGELVVQPRMGFSAPERMRAGLQ
                     AVRAARATTVGTITVDSYTRVGDHGSVREALRTGTPLNGYPLVEHGPETNHRLLAGLAG
                     PDFPVQLRHGSALPQRLFEAMLAAGLTATEGGPVSYCLPYSRTPLAEAARAWADGCELL
                     ADRAPAGRPVHLESFGGCMLGQLCPPGLLVALSVLECLFFVQHGIGSVSLSYAQQTNPA
                     QDLAAVRAMRRLAAEYLGAVRWHVVIYTYMGVFPRTRAGALRLLADSVRLARATGAERL
                     VTKTAVEALRIPTIEENIEALELAGEVAGRPDAAAGLSASAAEEAALHLEARTLIEATL
                     ALHQDVGEALVRAVRQGLLDVPYCLHPDNANQARTLIDETGRLRWRRTGRMPIAAASVS
                     TATGSPAFELLDQLRYIERRCDGVLPGPARPPRSVTG"
     gene            complement(9460..9936)
                     /locus_tag="ACTEI_RS35800"
     CDS             complement(9460..9936)
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018725261.1"
                     /locus_tag="ACTEI_RS35800"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="cobalamin-dependent protein"
                     /protein_id="WP_239082194.1"
                     /transl_table=11
                     /translation="MISPPARRRRCVVLSSVSSDSHTWNLVFLQLLLEEHGYQVENLGA
                     CVPDDLLVEVCLARIPDAVVISTVNGHGRLDGIRLARRLRAEPALAGIPMMIGGKLGLQ
                     GTADAASQAELIAAGFDAVFEAGSGPEVAEFLARLGAASPARPALAGPAPGGNG"
     gene            complement(10001..10600)
                     /locus_tag="ACTEI_RS35805"
     CDS             complement(10001..10600)
                     /EC_number="3.5.4.16"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621043.1"
                     /locus_tag="ACTEI_RS35805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP cyclohydrolase I"
                     /protein_id="WP_122981687.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 3e-48, bitscore:
                     162.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDLDVDKGPLAMMDGLGADPLEDLARLLLKEIGEDPSRDGLRD
                     TPARYARWWREFIEYDPGTVDTVFEATSAGQLVLVSGIEVWSLCEHHLLPFNCSLTIGY
                     RAADRLLGLSKFARIAHHRAHRLQVQERLVADIAADVARIAGTEDVGVIGTGEHLCMTM
                     RGIKTSARMTSSSLLGAFAEEGLLRSELLTHLQTAR"
     gene            complement(10602..11231)
                     /locus_tag="ACTEI_RS35810"
     CDS             complement(10602..11231)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="ACTEI_RS35810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_170206152.1"
                     /sec_met_domain="QueE (E-value: 2.4e-63, bitscore: 212.5,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.5e-09, bitscore: 35.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.7e-11, bitscore: 42.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGGCNLSCRWCDTPYTWDWEGVSDTGIAFDPKTELHRMPVSTV
                     LERLLALQVGLVVISGGEPLNQQKRLVPLVEALAGHGVEIEIETNGTRIPDPRLIAAGV
                     RFNVSPKLSHAGDSVEKRIVPAALERLAAMPSSTFKFVCRDSADLDEVSGVVAAAGITS
                     VWVMPEGQNGTDIDRHIRQLADEVVDRGWNITTRLHTLVWGHKRGV"
     gene            complement(11377..11739)
                     /locus_tag="ACTEI_RS35815"
     CDS             complement(11377..11739)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070497 -
                     6-carboxy-5,6,7,8-tetrahydropterin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621042.1"
                     /locus_tag="ACTEI_RS35815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-carboxytetrahydropterin synthase"
                     /protein_id="WP_122981688.1"
                     /sec_met_domain="PTPS (E-value: 3.8e-32, bitscore: 109.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRISKQFSFSASHQLDGLPANHQCGRLHGHNYLVEIELSAGRE
                     QLTAPGFVRDYGELSGFKGWVDEWLDHQHLNDVVKENPTAENLAIWIYEQWNPELPELT
                     AVRVSETPKTWAEYRP"
     gene            complement(11736..12416)
                     /locus_tag="ACTEI_RS35820"
     CDS             complement(11736..12416)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621045.1"
                     /locus_tag="ACTEI_RS35820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-cyano-7-deazaguanine synthase"
                     /protein_id="WP_122981689.1"
                     /sec_met_domain="QueC (E-value: 2.2e-51, bitscore: 173.0,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.1e-06, bitscore:
                     26.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKIVAIVSGGMDSVTMAHQLKEQGHDLHLLSVDYGQRHRKEHRF
                     AAAAAERLGAVHQVADLSAMGALLRGSSLTDPTVDVPEQTWTGYGESPNIVPNRNALLL
                     SVAFAVAVAEKAQAVAIGIMADDTVSVPDSTPAFLESFIAMERIATAGYAHPDLDLLAP
                     LSGLGKKDVVTLGERLGVPWTETWTCLRGQDDHCARCAACWERQEAFTAAGVQDPTIYQ
                     EHQS"
     gene            complement(12497..13744)
                     /locus_tag="ACTEI_RS35825"
     CDS             complement(12497..13744)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014805.4"
                     /locus_tag="ACTEI_RS35825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_122981690.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.4e-09, bitscore:
                     36.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.4e-07,
                     bitscore: 30.0, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNDHPADGSKPLLLLIGSGGQVWREYMLRAMATRYRLHLVSPAA
                     PTWQSPYITAHSAADTLDPDAMVAIAKESPEDYAGVLTYEETRVESAAAVATALGLRTS
                     SVEAVHACRDKFTGRQALKAAGVPQAESVAVGDLDEARQAAERLGYPVVLKPRALSASN
                     GVSLVPAPQNLAEGYRKATAIWFDEVPTYDRPVLVEEYLDGPEISVDAVCRDGRVTVLF
                     VARKRIGFAPGFEEVGHLVRADDPLLTDPELLRVIQAAHTAVGLTDTVTHTELRLTGSG
                     PRVVEINARVGGDRIPYLGGLATGIEVGLVAADLAAGAVPGTTASRQQVAAIRFLYPEH
                     DLTVESVEIDRERLPAEIHDVQVLAGPGRELRLPPVDHVRCRYALVVAVAATEQECEAA
                     LDRAAAAVVVRGTPLA"
     gene            complement(13807..15039)
                     /locus_tag="ACTEI_RS35830"
     CDS             complement(13807..15039)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024925.4"
                     /locus_tag="ACTEI_RS35830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_203723557.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.9e-09, bitscore:
                     35.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPSAVATVLFVGGKRTEAMDAAHSVGMTIGYLGPKDALSGRHQ
                     ELAEIVLLLPDVSPDRMVRAAVALYGVQPYDLAITMNDTYLQAVAQINHELGLTTNPLE
                     TVTAVNDKAFMREVLRGDEVGQVASAEVRSAQDLLALAGTLGFPLILKPTQGTGSRDIH
                     AVHDEARLRELAGELDFSLPGQQTSAPWLAEEYLVGQEFSVETFSAAGEHHLLAVTEKF
                     KTPNFVEIGHLVPARITAEQRDLIGAEVRRVLTALGVREGPAHTELILTDRGPRVIETH
                     TRPGGDAIVELVRLAAGFDIQELTFTWLAGKPLDLTPRPQAAAAAIWFLTLPEGEVTAV
                     GGLDQARAAEGVELAVLTAAVGDLIPPLRNSWDRQGEALAIGPDPDTALQLAQQAVGRI
                     QVEVVPSTASV"
     misc_feature    complement(15252..15267)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    complement(15620..15634)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
     gene            15807..18839
                     /locus_tag="ACTEI_RS35835"
     CDS             15807..18839
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="ACTEI_RS35835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_239082195.1"
                     /transl_table=11
                     /translation="MLAALLLNAGTAIQHERLVDMLWEEPPRSARQQIHNAVASLRRSL
                     AATPGSWNITTTEAGYLLQVPPDLVDVSLFRTMVAESEQLERLERVPAALESLERALKL
                     WRGPALAGLTGEWLEEAAVQLNEQHIAAVERTMALRLRLGQASSVVSALTGLVARHPYR
                     ETQRALLIEALHRSGRQAEALTVYEDGRQLLADEFGIDPGPALRRVHLQVLRSSPVTDP
                     DDAGAAAPDAGVTAHVTETRSGGAVLRNFLPHSTKEFTGRRTELDRLSDTALSSSSQAL
                     VISALDGMGGVGKTALAVRLAHELTEKYSDGQYFVDLHGFSPGRDPLTPDQALDHLLRQ
                     AGTAIEKVPPDLAGRSALWRGLLAGRRALVLLDNAVDVAQVRPLIPGATHSLVIVTSRR
                     RLAALEDAVPLSLNVLPPDDAEQLFIQIAGEERTRAAAAGVAEVIELCGRLPLAIRIAA
                     ARFRDRPSWSIDDLVKQLRSQRSRAQFLSAGDRDVMAVLRLSYRHLTPAQKRMFCLLSL
                     HPGEDFDAYAAAALADLPVARAEQVLEGLFDDNLLLQQAAGRYQFHDLVRDCSRLLLAA
                     EIDDRERTAATGRLLDYYLLIANEWCRPVAKGPFRFHAEIQHTLSRPEAENPAEATQLL
                     HTEYHNITAAAEYAREHGWHSHAWQIPCAMQPLLAGMNYGERAYVLFEGAVSAATAAGH
                     ADGRSMALTGMASVCREAGDNDQARALFEEAIAISRATGNGRHEVFQLAGLGITLLNDG
                     DLPAAEKVFATGYRAARELHDRATAALLANNLGVVAKDLGNYADALRYFTESAEHGNGF
                     STEDIAILTALNIGIVHQLRDNPEAATRQYEECRRRSRAIKFDVGEAVALVGLATVNRS
                     LGNFAAALEDGRDALAIARRTALREVECDALNALGDIFLSTGEASSAETLFAQSEQLAV
                     RHNLPRNAARSREGIAHVRFAEGDLAAARRDWEEAVRLFPAGVADAENSRRHLTSDTVL
                     QPRCQRCVVVARTAAPSFRSE"
     gene            18944..19075
                     /locus_tag="ACTEI_RS39105"
     CDS             18944..19075
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS39105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_262384556.1"
                     /transl_table=11
                     /translation="MKRNVFLAILGAGVLLALIPGVSGSEAPVAKRASMMVTCGSCP"
     gene            19126..19701
                     /locus_tag="ACTEI_RS35840"
     CDS             19126..19701
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04034.1"
                     /locus_tag="ACTEI_RS35840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SdpA family antimicrobial peptide system protein"
                     /protein_id="WP_122982626.1"
                     /transl_table=11
                     /translation="MGHEPGEDRRAFAFTATVLAVLLLAALLAQLPPGSMPHTLSRRAA
                     SYELLWPQGWSFFSAAPRQDRTVAYRVQPDGSLSTEDSVQARPGSWWGLRRTTYFRLVE
                     TEYVASRIPPSSWITCDAPTAASCLQRAGRPAWPVTNNPFHASALCGRVLFAVERPDLG
                     NDRLRRGAVPRRVVAIAPTSLQCAPDRK"
     gene            19704..20627
                     /locus_tag="ACTEI_RS35845"
     CDS             19704..20627
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04033.1"
                     /locus_tag="ACTEI_RS35845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sporulation-delaying protein SdpB family protein"
                     /protein_id="WP_164466247.1"
                     /transl_table=11
                     /translation="MIDPLRHLPAYDPRGLWLACARSMFAAATLSIIVCNPDDVLFLRV
                     GDQSAVRCGGVQGLSLWCLGQVGDGDLSLARIVSVLVLGLVVVGFRPRWTCIPHWYVTY
                     SLCVSMTLPNGGEHVAQIATMLLIPLCLGDHRTWQWQSPVTALHASWRGASLAAMYVFR
                     VQVCIIYAHAAWSKLMEQSWRDGTAEYVIFFDPHYGPYPPVREALLPVLSSPSVIVGLT
                     WSTIGMEIAIAVLALGTRRMRLAALGLAVLLHGGIIALMGMPSFGLIMIALLTTNAVAG
                     ANQAGPAPTHSKGSPVDRDNVAVHPG"
     gene            20599..21594
                     /locus_tag="ACTEI_RS35850"
     CDS             20599..21594
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="ACTEI_RS35850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_239082198.1"
                     /transl_table=11
                     /translation="MTTSPFTPDDAAENELADYYQLALADARTERPDDPEPTYEAAIGR
                     LRTPLTALGRCVHRAAYADGRLVGLISAGLPEDENVEQAVVDVKVHPDHRRRGIGTTLL
                     RTLLPTLASERRTLLAGWGLIEGKSGASWAKRRGFRVVYRQVLQGLDVVATDRELWRVA
                     APEGYRTVQWVGTAPAELLASYAEARSAIHDMPSADWSYRPPTWTPERIRRAEAELRER
                     NVEQRVVAAVHEETGTAVGLTELEFYPHRPDFGYQQETAVLAGHRGRGLGRLMKARMMD
                     WVVQERPGTTHVWTTTADDNVHMRRVNEQIGYATIRVMVNVEVETDAVQL"
     misc_feature    complement(22283..22298)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.43"
                     /tool="antismash"
ORIGIN
        1 ccggcgccgg ccgcaggccc gtccacgacg gtgcccgccc gctggactcc cgtcgggcac
       61 gcgggcacga acgcgccgtg atcaccctgc gtagtctcgc cgcggtcgcg ttcttcatcg
      121 cgccaccccg aggatccgac gtagatcaga cgtagatcgg gcgtagatcc gacgtagatc
      181 gggcgtagat cgcagcgccg gaagatcggg ggcggaagca gtcaggacag tcggacctgc
      241 cgatggcgga tggatgtccg agtggccggg cgggaatgcg aaggaggctc caggatgctc
      301 tcgccagaga agaatcggat gctgacccag gtgggcgccg gtaccccgat gggcgaactg
      361 ctgcgcaggt actggcaccc gatcgcaccg gccatggaac tccgcgagcg gcgggtcaag
      421 ccgatcaggc tgttgggcga ggacctggtc ctgttccgca agccgagcgg cgggcacggg
      481 ctgctctccc ggcactgtcc gcaccggctg accgatctca gcctgggctg ggtggacggc
      541 gacctgatgc ggtgtgccta ccacgggtgg gggttcgact ccgacgggcg gtgcgtggag
      601 cagccgttcg aggaggccgg gccggccggc gggttccacg acaaggccgg ggtgaagtcc
      661 taccccaccg cgaccctggc cgggctggtg tgggcgtacc tgggcccggg gcccgccccg
      721 ctgctgcccg acttcgagac gttcagctgg gagcacggct tcgtcgagct gatcctcacc
      781 gagctgccgt gcaactggtt ccagtgccac gagaacggca tggacccggt ccacttcgag
      841 tggctgcact caaacggcaa cgcggtgcgg ctcaaccccg aggcgccgct ctacgcgccc
      901 cggcacacgg agatcgactt cttggagttc gagcacggct tcgtcaacgg ccgcgaggtc
      961 gagaccgaga acgcgccgga ggggcccttc gcccggtcca gcagcacggc cgagggcggc
     1021 atcctctgcc tgtggccgta caccctcgcc tcgggcaaca cggtcgagtt ccgggtgccg
     1081 gtggacgacc accggaccct caacatcacg tggcagtact cggtgctccc cgacgacgtc
     1141 cggaccggcg tgccggagtc ggaggaggtg ccgtactggt acggcccgct caccgagccc
     1201 gggagcgacc gaatcatcac ctcgcacacc ggcaaccagg acttcgcggt ctggatcggc
     1261 cagggcacgg tcaccgaccg gagcgccgag cggctggggc gcagcgacaa gggcatcacc
     1321 ctgctgcggc gccgctacct ggaggcgatc gagcaggtcg ccaggggcga ggacccgccg
     1381 ggcacggtgc gtgaccccgc cgcgaacgtg cggatcccgc tcccgctccc ccggaagttc
     1441 atctacaccg agggcgtgcc ccgcgtggtg ttcgaggaga agctcgccgc ccggaagaag
     1501 agcgggctgt acggcatcgg tggcttcctg gcggtccagg ccggacggcc ggatcacatc
     1561 cagacgatgt acgagaaggc cgccggcatc acggacgggt cggctctcgg ctccggcggg
     1621 gccgggtagc cggcgcgccg gcgcggccgg cgggtcctgg ccgttgagga tcgcgcggtg
     1681 cacctcggac aggtgggcgc ccgggtcgat gccgagctcc tgggccagcc ggcggtgcat
     1741 gcgccggtat acctggagcg cgtcggcccg catgccgcac cggtagaggg cggtcatcca
     1801 ggccgcgtgc aggtcctccg cgaacggtgc cgcctggcag ctggccgaga tctcggccag
     1861 cagtgatccg tggtttccca gggccagttc gcactcgtac cgggccagca gagcggcttc
     1921 ccgctgctgg gccagcgact cgcgccggcc gtggcagagc ggcccgggaa gcccggcgag
     1981 cgcggtggtg ccaccccaca gaccgagcgc ggtcccgagc cgtgcggcgt ccgcgcggtc
     2041 gtcgccggtg cggcgggcgg cggcgagatc ggcgaattgc agggcgtcga cggccgacct
     2101 cgggacgtcc agcgcgtagc cgccgccgga gcggacgatc agcccggggt ccagaccctt
     2161 gcgcagccgc aggacgtagt tggcgatcat cgacaccgcg ctggccggcg gccgttcccc
     2221 gaacagcccg tcgaccagct catccgtgct gaccggggtg ccggcgcgca gcgcgagcgc
     2281 cgccagcacc gccgcctgct ggggcggcat ccgcggcatc cgggtcggcg gggcgccctc
     2341 gcgcaggacc gccggggcac cgagaagtac gaacctgaac actgaattcc tccacggatc
     2401 gggcgttcct ccgaacgcgg tggtgccgcg gccccgtcaa acctgctgga gccgcgactc
     2461 gcgggtggtg tcatccgagg cggagcccgc ccgcttcggc cgcccctgca agcggttgag
     2521 gatcgggccg gtggagagcg tggtcaggac ggccatcgcc accagcaggc tgtaggagga
     2581 gtcgttcagc aggcctgcct gacgtccggc ggtgagcacg atcagctcgg tgagcccgcg
     2641 ggtgttcatc agggcgccca ggatcgcggc ttcgcgcggc cgcaggccgg acacccgggc
     2701 cgccaccatg gtgccggcga ccttccccac cacggcgatc gcgagcagca ccagcagttg
     2761 caccagctgg gtggcccgca ggacggaaag gtccacctgc cagccggcca ccacgaagta
     2821 gaccggcatg agcaggccca ggccgagccc ttcggcgctc tcccgcaccg gcttcagcgc
     2881 gcgctccccc gccgggccgc gcaggccgga caggacgatg ccgaagagga aggcgccgag
     2941 cacgaagtgc aggcccatcc attcggtgga ggcggccgag gccagcaagc cggccagggc
     3001 gacgaccggg ttcagccggc cggcgcgccg ctgcaccagg cggcgcagca ggacggtgca
     3061 ggcggccatc accgcgacgt acgggagcaa ccacagcagg cgccacggct ggtggccgcc
     3121 ggcgccgagg gccagcacac cggccagcag cacccaggcc agcagatcgc agaaggccgc
     3181 tccggccagg gccagccggc ccagcggttg ccgggtcatg ccgcggtcgt ccaggatccg
     3241 ggccagcacc gggaaggccg tgacggagag ggccaaaccc atgaacaggt gggccccgag
     3301 cggggtggcg tccggcgtcg cggtgtccca ccaggcgccg agagaggttc ccatggcgaa
     3361 gggcaggacg atcgagccga gcccgatgcc gatggcggcc cgccggggcg cgtggccgtc
     3421 cccccggcgg aactccaggc cggtgacgaa catgaacagg gcgatcccca cgttcgcgaa
     3481 cgcgatcagg tagccgcgca cctgcccggg gaacagcgtc tccgcgacga cgccgtgcag
     3541 cacggtgggg ccgagcagga tccccatcac gacctcgccg atgaccgccg gctggccgaa
     3601 ccggcgggcg agcgcgcccg ccgcccgggc caggatcgcg atcagggcca ggtcgagcag
     3661 aagaatgacg atggtgttgc tgtccatgcg ctccggcttc ctcgtacgcg tcggcggccg
     3721 tgcccccggc agggcgcccg ggggcacggc cgggccacgg gtcggtcagg cgttgtccac
     3781 cgcgcgggcc gcctcggcct ccgggttctc ccaccagcgg tcgttaccca ccaggtcctt
     3841 ctccaggtcg cgcttggcgg cccaggtcat gttgaggatg gtgcgggtcg agtcctcgct
     3901 cagcggcacg gtgcggtgca gggtggtgtc ggtgcgcagc aggtacaggt caccggactc
     3961 cagcccgtgg gtgttgatct cgcgctcgca gagcgtctgg ttgatccgcg ggttgctctt
     4021 gtcccagtgg gtgtgcggca ccgcctgcag catcccgccg tgctcgatgg gcggcatccg
     4081 cagcgcccag atcagcgcga agctgtagtc gccccagtgc cagccgtggg tgtccgactt
     4141 gaactcctgg tgggtgatca ggtagcgctc gtcgctggag acctccggga tgatctcctc
     4201 ccgggtgatg ccggccagga atccgagcag cacctcggag cgggacagcg tactgatgag
     4261 ttcgctcttc tcgatctcct cgctcttgac cacgctcatc cggcggggcg tgttgccggt
     4321 ggtgctgagc agcaggttgc ggcgctcctt gtgctgctcg atcagcaggt cgcactcctc
     4381 gcggaccgcg gtctgcagct cgtccggcac gagccggttg gcggcgtcga acttgacgaa
     4441 gccgaagcgg tggaagcggt cggcaagctg cgccacggac tcgggggtgt agcgctcggc
     4501 caggaacttg gccaggttct cgtcgatctg ctcgacattc atgcgggtgt ctccttcaac
     4561 tggtggtggg aaggtctccg gcgggccgag ggccccggac gttccaggtg aggaccgcgg
     4621 acaggaccgc gatcacgggg atggcgcaga gcgccgtcac attgccgacc tcggttgcgg
     4681 cccaggcgcc gacggccgcg ccggcctgcg tgaggctgct cagccaggcc tgggtctcgg
     4741 cggcggtccc ctccggggcg aggtcaccgc ccgcggtgaa cagcgcgccg aaggtcgagc
     4801 cgtaggccag gccggtgatc ggacaggcca gcgtcatggc cagggcggac atctgggagg
     4861 tgacggccag cagcacgacg cccgacgcga agaccccgat cagcaccgag agcttggggc
     4921 ccctggccag caggccgggg acggcgccca gggcgaggct gccgacgatg ctgccgaccg
     4981 agagggcgcc gatctggatg ccgatgtacc cggtggtgcc ccgctcggcg ttgagcaccg
     5041 agatgaccac gtcgatcgcg gtgatcatcg cgctgaacgc ggcgttggcg atcagtaccc
     5101 ggcgcagcgg agccgagcgc agcgggcccg cccagtgccc gccgccgcga cggcggaccg
     5161 gcggcgggac gttcgggaag ctgagcacca gcaggaccgc gaccatcgtc agcgctccgt
     5221 acagaccgaa cgccacctcg ccggacacgc tgaggcagag ccacgcggcc agggccggcc
     5281 cggtgatctg cacgacgtcg ctggtcgcgg cgtcgagcgc catcgctgtg accagccgct
     5341 gttcgccggc cagcacccgc cacagggtgc gcatgatgat gcctaccggt ggtgcggtga
     5401 cgccgctgac cgcggccagg gccagcacca gcggggccgg gccccggtcg gcggccaccg
     5461 cggtcagcga gccgagcgcg accacgtaga acagcaggca gacgaccagg atcagccggt
     5521 acgggtagcg gtccatcagc cggccgcgga tcggggcgga cagcccctgg ccgatcgcca
     5581 tgcagctcac cgccaggccg cccgtcgcgt aggagtagcg gggcccgagg tagagcagca
     5641 ggctcagcga aaccatggtg accggcagct tcgacaccag agcggcgatc agcatgcggc
     5701 tgaccccggg aaccgccagc agctcccggt agccggcggg cagccgcagc cgcttccgcc
     5761 ggcccgggcg cgccgcctgg gtctcaggcg gaggcatcga atgcgatctc cagcgagacc
     5821 agcgcgcgga tctcggccag cgcccggacc accgcgtcct ggtccggacc ggagacccag
     5881 gccccgaccg ggatggtctt ggtgtcgcgg gtgaccggca cgtggtcgcc cggccggtag
     5941 gagaccagga ccttgtccac gctcgggtgg ctctccagct ccgccagccc gtgtaccgcg
     6001 accagcgtgc cgggcgcgtc gtcgttgcgg atggcgatcg ctccgaacat cgcccggacg
     6061 tccaggtcct ggtccatgat cgccggacgt cggccgaggt agcaggtgag cgcgtcgtgg
     6121 aagggccgga tcgcggtgta gtcggcccac tggtcggtgg ccggtccgcc cggaagccgg
     6181 gcgccgatct ccatcagata gacgccgtcc ggagtgcact tgacctcggt gtggctgggg
     6241 ccgcggcgca cgccgaacgc ggtgagaacc tggtggacgt actcctcgac gcgggcccag
     6301 tcggggtcgt cacgggtcgc ctggacgttg ttccacagcg ggaagtcgta gtcccggtcg
     6361 tccggctgcc ggtactccca catgtccatc acccggtgct ggccgtcgct gctgaagcag
     6421 ttgacggcga actcgcgtcc gcggacgtac tgctcgacca gccactccct gaccggccat
     6481 ccgaacaggt cgttctcctc ggggatccgc aggctcttgg cctcctcggc gtcgcggacc
     6541 agggtgacgc cgtgcgagcc ggcgcccatg gtgggtttga cgatgaccgg gaagccgatc
     6601 tcctcggccg ccgccggcac ctcggccatg tcgtgcacca gccggaacgc cgggatccgc
     6661 accccggcct gcgaggcgtg cgagcgcatg gcggccttgt tgcgccgggc ccaggccagc
     6721 tcgacgtcgt taccggccag cccgagctcg tgggccagca catcggtcag gtggacggcg
     6781 gactccatcg ccggcaccac cgccttgact tcgaagtcgg tgtccgccag ggcggcgagc
     6841 acgtcggggg cggtggaggc gtacagcgac gcgtcgtcgt cccgggtgtg ctcgggccac
     6901 cgggagttca gctcggtggg ttccaccgtg tagagggaga ccacgtggag cccgaaatca
     6961 cgggccgcct tcttgtagcc ttcgccggtc ttgaccgggt cgatgaggag tacggcgggc
     7021 ttgcggctgc tcaagggatc gttccttctc ggacggagtg gggtgccggg gccggtcggc
     7081 cgccgtcagg cggtgggcag cagttcgggg tggtggcgct cgatgacctg cgggaaggcc
     7141 cggatcatcc ccttcatgac gttctctccg tagccggcga agagcgggtt ggcggggtcg
     7201 ggtacgacgc ccccggccgc ctcgacgtac gggccgggca gcggctgcat cgacgcgtcg
     7261 aggcgggggt tgtagaagaa cggggcggag tagcggtcca ccccgggggc cggccgcacc
     7321 acccggtgcg tggtggcacg caggtagccg cgggtggcca cctccagcag ctcaccgagg
     7381 ttcaccacga acgcccccgg caccaccggc acgtcggcga acacgccgtc ctcgaccgcg
     7441 acctggagtc cgcccttgtc gtcctgcagc agcagggtga ggatgccgta gtccttgtgg
     7501 atgcccacgc cctggtctcc gtcgccggtc tcgccgtgct ccgggccggg gtagtgcagc
     7561 agcttgaagt ggacgtgcgg gtccggggtc accacgtcgt ccaggaagtc ggccgggacc
     7621 tccagggatt cgaggatcag tccgagcagc cggtgcgcga caccggtcag ctcgcccgtc
     7681 cagcggtgga ccgcgtcggc cagttccggc atggcgggcg gccactggtt ggggccggcc
     7741 agccaccggt aggcgggctc gccggggccc ggcgcgacgg acgggcgctc cgggccgatg
     7801 tccagctggc gccgctggtc cgggatgccc tgggtcaact cccggccgat ctccgaatag
     7861 ccgcggaagt gcggggagtt gaggatgctc agggcggccc gctccggctc gggcagcgcg
     7921 aagaatctgc gagcgagctc cagcagcgcg tcgccgccgg tcacgccatg acccaccagc
     7981 tggaagaagc cgatgtcatg gaccgcggaa cgcagccggt cgaggaactc ggcacgggcc
     8041 tgcggcccgc gctcggcgtc gcgcagatcg atgacaggga acagctcgga caaggtaggt
     8101 cctccatcgg gagtcaggac gggagggggt tgggcgagcc ggctggcacg cctcagccgg
     8161 tcacgctccg cggcggccgg gccggacccg gcagcacgcc gtcgcagcgt cgttcgatgt
     8221 agcggagctg atcgagcagc tcgaaggcgg gtgagccggt ggcggtcgac accgaggcgg
     8281 ccgcgatcgg catccggccg gtccgccgcc accgcagccg cccggtctcg tcgatcaggg
     8341 tccgggcctg gttggcgttg tcggggtgca ggcagtacgg gacgtccagc aggccctgcc
     8401 ggacggctcg caccagcgcc tcaccgacgt cctggtgcag ggcgagcgtc gcctcgatca
     8461 gggtccgcgc ctccagatgg agggccgcct cctcggcggc gctcgccgac agtccggcgg
     8521 cggcgtccgg ccgccccgcg acctcgccgg ccagctccag cgcctcgatg ttctcctcga
     8581 tcgtggggat ccgcagcgcc tcgaccgcgg tcttggtcac cagccgctcg gccccggtgg
     8641 cccgggccag ccggacgctg tccgccagca gccggagcgc tcccgccctg gtccgcggga
     8701 agacccccat gtaggtgtag atgacgacat gccagcgcac cgcgccgagg tactcggcgg
     8761 ccagccgccg catggcccgc accgcggcca ggtcctgggc cggattggtc tgctgcgcgt
     8821 agctgagcga gacgctgccg atcccgtgct ggacgaagaa caggcactcc agcacgctga
     8881 gcgccaccag cagtcccggg gggcagagct ggcccagcat gcagccgccg aagctctcca
     8941 ggtggaccgg ccggccggcc ggggcgcggt cggccagcag ctcgcagccg tcggcccagg
     9001 cccgggcggc ctcggccagc ggggtccggc tgtagggcag gcagtacgac accggcccgc
     9061 cctcggtcgc ggtcaggccg gcggccagca tggcctcgaa cagccgctgc ggcagggccg
     9121 agccgtgccg cagctggacc gggaagtccg gtccggccag accggccagc agccgatggt
     9181 tggtctcggg gccgtgttcc accagcggat acccgttgag cggcgtcccg gtgcgcagcg
     9241 cctcccggac cgaaccgtgg tcacccaccc tggtgtaact gtccacggtg atggtgccga
     9301 cggtggtggc gcgggcggcg cgcacggctt gcaggccggc ccgcatccgc tcgggagcgg
     9361 agaatcccat ccggggctgg accaccagct cgcccgcccg ggaacgctcg tggacgaagt
     9421 cgctgaagtc gttcccggcg ggccgaggca gggtgccgct catccgttcc ctcccggggc
     9481 cggcccggcg agcgccggcc gggccggcga cgccgcgccg agacgggcga ggaactcggc
     9541 cacctcgggg ccggagccgg cctcgaagac cgcgtcgaat ccggcggcga tcagctcggc
     9601 ctgcgaggcc gcgtcggcgg tcccctgcag gccgagcttc ccgccgatca tcatcgggat
     9661 cccggcgagc gccggctccg cgcgcagccg gcgcgccagc cggatgccgt ccagccggcc
     9721 gtgcccgttg accgtgctga tcaccaccgc gtccgggatc ctggccaggc agacctccac
     9781 caggaggtcg tcggggacgc aggcgcccag gttctccacc tggtagccgt gctcctccag
     9841 cagcagctgg agaaagacca ggttccaggt gtgcgagtcg gaggagacgc tggacagcac
     9901 gacgcatcgc ctgcggcgcg cgggcgggct gatcacgggg gactccttcg ggctcggcag
     9961 gtcggtgcgc ggacggcggc gcgccggccg cggcgcgggg tcagcgggcg gtctgcaggt
    10021 gggtgagcag ctcggaccgg agcaggccct cctcggcgaa cgccccgagc agggagctgg
    10081 aggtcatccg ggcgctggtc ttgatgcccc gcatggtcat gcacaggtgc tcaccggtgc
    10141 cgatcacccc gacgtcctcg gtgccggcga tccgcgccac gtcggcggcg atgtcggcga
    10201 ccaggcgttc ctgcacctgc agccggtgcg cccggtggtg cgcgatccgg gcgaacttcg
    10261 acagccccag cagtcggtcc gcggcgcggt agccgatggt cagcgagcag ttgaagggga
    10321 gcaggtggtg ctcgcacagc gaccagacct cgatgccgga gaccagcacc agctggcccg
    10381 cggaggtggc ctcgaagacc gtgtccaccg tgccggggtc gtactcgatg aactcgcgcc
    10441 accagcgggc gtaacgggcc ggggtgtccc ggagaccgtc ccgcgagggg tcctcgccga
    10501 tttccttcag cagcaggcgc gccaggtcct cgagggggtc cgcaccgagc ccgtccatca
    10561 tggcgagagg gcccttgtcc acgtccaggt cggtactcat ctcaaacgcc tctcttgtgt
    10621 ccccagacca acgtgtgcag cctggtcgtg atgttccagc cacggtcgac gacctcgtcg
    10681 gccaactgcc ggatgtgccg gtcgatgtcc gtgccgttct ggccctcggg catcacccag
    10741 accgaggtga tgcccgccgc cgccaccacc ccggagacct cgtcgaggtc ggcgctgtcc
    10801 cggcagacga acttgaaggt gctggacggc atggcggcca ggcgctccag cgcggcgggc
    10861 acgatccgct tctcgacgga gtcgccggcg tgcgagagct tcggcgagac gttgaagcgg
    10921 acgccggccg cgatcagccg ggggtccggg atccgggtcc cgttggtctc gatctcgatc
    10981 tcgacgccgt gtccggccag tgcctccacg agcgggacca ggcgcttctg ctggttgagc
    11041 ggttcaccgc cggagatcac caccagcccg acctggaggg cgagcaggcg ctccagcacg
    11101 gtggagacgg gcatgcggtg cagctccgtc ttcggatcga acgcgatgcc ggtgtcgctg
    11161 accccttccc agtcccaggt gtagggggtg tcgcaccagc ggcatgaaag attgcagcca
    11221 cccagcctca ggaaagcgca gcggcggccg agtgatcgtc cttctccctg gaaggactca
    11281 agtggggccg aagatctcgt tgacgacgag ttccggttcc actgggcacc acctcctcaa
    11341 acagacgggc cggggtgtcc cccgccgtcc tgcggctcag gggcggtact ccgcccaggt
    11401 cttgggggtc tcggagaccc gtacggcggt cagctccggg agctccgggt tccactgctc
    11461 gtagatccag atcgccaggt tctccgcggt cgggttttcc ttgaccacgt cgttgaggtg
    11521 ctggtggtcc agccactcgt cgacccagcc cttgaagccg gacagctcgc cgtagtcgcg
    11581 gacgaagccg ggggcggtca gctgttcccg gccggcgctg agctcgatct cgacgaggta
    11641 gttgtggccg tgcaggcggc cgcactggtg gttcgcgggc agcccgtcga gctggtggct
    11701 ggcggagaag gagaactgct tggagatgcg tagcgtcatg actggtgctc ctggtaaatg
    11761 gtggggtctt ggacaccggc cgcggtgaac gcctcctggc gctcccagca cgcggcgcag
    11821 cgggcgcagt ggtcgtcctg cccgcgcaag caggtccagg tctcggtcca cgggacgccg
    11881 agccgctcgc ccagcgtgac gacgtccttc ttgcccaggc cggacagcgg cgcgagcaga
    11941 tcgaggtcgg ggtgggcgta cccggcggtc gcgatgcgct ccatggcgat gaaggactcc
    12001 aggaacgccg gagtgctgtc ggggacggac acggtgtcgt ccgccatgat cccgatggcg
    12061 acggcctggg ccttctcggc caccgccacc gcaaacgcca ccgacagcag cagggcgttg
    12121 cggttgggga cgatgttcgg gctctcgccg tacccggtcc aggtctgctc cgggacgtcg
    12181 acggtcgggt cggtgagcga ggagccgcgc agcagggcgc ccatcgcgct caggtcggcc
    12241 acctgatgga ccgcgccgag ccgctcggcc gcggcggccg cgaatcggtg ctccttgcgg
    12301 tggcgctgcc cgtagtcgac ggagagcagg tgcaagtcgt ggccctgctc cttgagctgg
    12361 tgcgccatcg tgacggagtc catgcctccg gagacgatgg cgacgatctt cggcacagcg
    12421 tttcccccgt tgtgtcggtg ctgattgctt cggtggccgc ggccggtggt ccggccgcgg
    12481 cggttccggc tcccgctcag gcgagcgggg tgccgcgtac gacgaccgcc gccgcggcgc
    12541 ggtccagggc cgcttcgcac tcctgttcag tggcggcgac ggccaccacc agggcgtacc
    12601 ggcagcggac gtggtcgacc ggcggcagcc ggagctcccg gccgggaccg gccaggacct
    12661 gtacgtcgtg gatctcggcg ggcagccgtt cccggtcgat ctccaccgac tcgaccgtca
    12721 ggtcgtgctc ggggtacagg aagcggatgg ccgccacctg ctgccgggag gccgtggtcc
    12781 cggggaccgc gccggccgcc aggtcggcgg cgaccagccc gacctcgata ccggtggcga
    12841 gcccgcccag atacgggatc cggtcaccgc cgacccgggc gttgatctcc accacccggg
    12901 ggccggaccc ggtgagccgt agttcggtgt gggtgaccgt gtcggtgagg ccgacggcgg
    12961 tgtgcgcggc ctggatgacc cgcagcagct ccgggtcggt gagcagcggg tcgtccgccc
    13021 ggaccaggtg gccgacctcc tcgaaccccg gcgcgaaccc gatccgcttc cgggccacga
    13081 acagcaccgt cacccggccg tcccggcaga ccgcgtccac gctgatctcc ggcccgtcga
    13141 ggtactcctc gaccagcacc ggacggtcgt aggtcgggac ctcgtcgaac cagatcgcgg
    13201 tggccttgcg gtatccctcg gccaggttct gcggcgccgg gaccagcgac acgccgttgc
    13261 tcgcggacag cgcccgcggc ttgagcacca cggggtagcc gagccgctcg gcggcctgcc
    13321 gggcctcgtc gaggtcgccg accgcgaccg actcggcctg cggcacgccg gcggccttca
    13381 gcgcctgccg gcccgtgaac ttgtcgcggc aggcgtgcac cgcctccacc gagctggtcc
    13441 gcagcccgag ggcggtggcc accgcggcgg ccgactcgac gcgggtctcc tcgtacgtga
    13501 gcaccccggc gtagtcctcc gggctctcct tggcgatcgc gaccatcgcg tcggggtcca
    13561 gagtgtccgc cgccgagtgc gccgtgatgt agggcgactg ccaggtggga gccgccgggg
    13621 ataccaggtg cagccggtac cgggtggcca tggcgcgcag catgtactcg cgccagacct
    13681 ggcccccgct gccgatgagc agaagcaggg gcttggatcc gtcggccggg tggtcgttgg
    13741 tcatacgggt caccgttcag tgtgcggagg acgggtggtg tcaccgggcg ggacgcccgg
    13801 tgggcgtcag accgatgcgg tggacggcac gacctcgacc tggatccggc cgaccgcctg
    13861 ctgtgccagc tgcagcgccg tgtccgggtc cggtccgatc gcgagcgcct cgccctggcg
    13921 gtcccaggag ttgcgcagtg gcgggatcag gtcgccgacg gccgcggtga gcacggccaa
    13981 ctccacccct tcggcggcgc gcgcctggtc caggccgccg accgcggtca cctcgccctc
    14041 cggaagggtg aggaaccaga tcgcggccgc ggccgcctgc ggccgcgggg tcaggtccag
    14101 gggcttgccc gccagccagg tgaaggtcag ctcctggatg tcgaagccgg cggccagccg
    14161 gacgagttcg acgatcgcgt caccgccggg ccgggtgtgc gtctcgatga cgcgcgggcc
    14221 gcgatcggtg aggatgagtt cggtgtgggc cgggccctcc cgcacgccga gcgcggtcag
    14281 cactcgccgc acctcggcgc cgatcaggtc ccgctgctca gcggtgatcc gggccggcac
    14341 caggtggccg atctccacga agttcggcgt cttgaacttc tcggtcacgg ccagcaggtg
    14401 gtgctcaccg gccgcgctga aggtctccac gctgaattcc tggccgacca ggtactcctc
    14461 ggccagccac ggcgccgagg tctgctgacc ggggagcgag aagtccagct ccccggccag
    14521 ttcccgcagc cgggcctcgt cgtgcacggc gtggatgtcc cggctccccg tgccctgggt
    14581 gggcttgagg atcagtggaa aaccgagggt gccggccagt gcgaggaggt cctgcgcact
    14641 gcgcacctcg gcggaggcga cctggccgac ctcgtcgcca cgcagcacct cacgcatgaa
    14701 cgccttgtcg ttgaccgccg tgacggtctc caacgggttg gtggtgagcc ccagctcgtg
    14761 attgatctgc gccaccgcct gcaggtacgt gtcgttcatg gtgatcgcga ggtcgtacgg
    14821 ctggacgccg tacaacgcca ctgccgcccg gaccatccgg tccggtgaga cgtcgggcag
    14881 cagcaggacg atctcggcca gctcctggtg ccgtccggac agagcgtcct tgggccccag
    14941 gtagccgatc gtcattccca cgctgtgcgc cgcatccatc gcctctgtgc gcttaccccc
    15001 gacgaacaac acggtggcga cggccgatgg cctggtcacc ctgttctcct ctggctcggc
    15061 actgagccag ccttgggtcc tcgcattcac aggacgatgc cccccgatca catgtgcagc
    15121 tcacagcgcg cctcggcgct gacgagatca accatcgcga ccggggcagc ctgcgtcgag
    15181 gaggatcggc cggagacttc gcgaggggcg gaggaagagc ctgaggtttc accggcagta
    15241 ggacacggat agttcacatc tgccaacttc gtggccactg tgacgcgttg gataggctgt
    15301 cgtcgttggc cggtcctcgg acagatgctc aggtggcggt ggtctgcctg cggtaatgcg
    15361 ggcgggaggg gcagttgaca gggagccaca tggatgacca gcgcactatc ggccaactac
    15421 ttcgggagtt ccggatatca gcccggctca cccaggaagc cctggcggaa cgtgcggccg
    15481 tcagtgcccg cacggtgcgc gacatcgaac ggggcgccgt gatcggaccc cgccacagca
    15541 ccgcgagatc actcgcggac gcgctcgggc tgacgggcgc cgaccgggat cacttcctgg
    15601 ccgtcgcctc cgccgcctcg tgggagagct cgcaagcaca ggacgggtac gtcgatcccc
    15661 cggcggcacc gatgtcggag gaatggcccg ccgacgctgc ggtcttctcc gcggatccgg
    15721 ccgtgccacc tttccgcatc ctcggccccg tcgaggtcgg cgccccgggt aggccgatat
    15781 ccctgccggg aacgcggcag aggaagttgc tcgcggccct tctgctcaac gcgggcaccg
    15841 cgatccagca cgagcgcctt gtggacatgt tgtgggagga accaccccgg tccgcccggc
    15901 aacagatcca caacgcggtg gccagcctgc ggcggagtct cgccgcgacg cccgggagct
    15961 ggaacatcac caccacggag gccggctatc tcctccaggt gccgccggac ctggtggatg
    16021 tttcgctgtt ccgcacgatg gtcgcggaaa gtgaacagct ggaacggctc gaacgggtgc
    16081 cggcggcgct ggagtcgctc gagcgggcgt tgaagctgtg gcgcggcccc gctctggccg
    16141 gcctgaccgg cgagtggctg gaggaggccg ccgtccagct caatgagcaa catatcgcgg
    16201 cggtcgaacg gaccatggcc ctccggctcc ggctgggtca ggcgagttcc gtggtcagcg
    16261 ccttgaccgg cctcgttgcc cggcacccgt accgcgagac gcagcgcgcg ctgctcatcg
    16321 aggcgctgca ccgcagcggc cgtcaggccg aggcgctgac ggtgtacgag gacggccgtc
    16381 agttgctggc cgatgagttc ggcatcgatc cggggccggc cctgcgccgg gtacacctcc
    16441 aggtcctccg cagcagcccg gtcaccgatc cggacgacgc cggggcagcc gcgccggatg
    16501 ccggcgtgac cgcgcacgtg accgaaaccc ggtccggagg ggcggtactg cggaacttcc
    16561 ttccccacag caccaaggag ttcaccggcc gcaggacgga gctcgacagg ttgagcgaca
    16621 ccgcgctgtc gtcgtcgtcg caagcgctgg tcatctcggc gctcgacggg atgggagggg
    16681 tcggcaagac cgctctggcg gttcgcctcg cgcacgagct caccgagaag tacagcgacg
    16741 gacagtactt cgtggacctg catggcttca gccccggccg cgacccgctc acccctgatc
    16801 aggcgctcga ccacctcctg cggcaagccg gcacggcgat cgagaaggtt ccgccggatc
    16861 tggccggacg cagcgcgctc tggcgcggcc tgttggccgg caggcgggcg ctcgtgctgc
    16921 tggacaacgc cgtggacgtc gcacaggtgc ggccactcat ccccggagcg acccacagcc
    16981 tcgtgatcgt gacgagccgg cgccgtttgg cggcgctcga agacgctgtc ccgctctccc
    17041 tcaacgtgct gccgccggac gacgccgagc agctcttcat ccagatcgcc ggggaggagc
    17101 ggacgagggc tgccgctgcc ggtgtcgccg aggtcatcga attgtgcggg cggctgccgc
    17161 tggccatccg gatcgccgcc gccaggttcc gggaccggcc cagctggagc atcgacgacc
    17221 tggtcaagca gctgcgcagc cagcgcagcc gggcccagtt cctctccgcc ggcgaccgcg
    17281 acgtgatggc cgttctgcgg ctgtcctacc gacacctgac gcccgcgcag aagcggatgt
    17341 tctgcctgct cagccttcac ccgggggagg acttcgacgc gtacgcggcg gccgcgctgg
    17401 cggatctgcc cgtggcccgc gcggagcagg tcctcgaggg tctgttcgac gacaacctgc
    17461 tgctgcagca ggctgccggt cgctaccagt tccacgacct ggtccgggac tgttcgaggt
    17521 tgttgctggc cgctgagatc gacgatcggg agcggaccgc cgcgaccggc cgcctgctgg
    17581 actactacct cctgatcgcc aacgagtggt gccggccggt ggccaaggga cccttccggt
    17641 tccatgccga gatccagcac acgctgtctc gcccggaggc ggagaacccg gccgaggcga
    17701 cgcagctgct gcacaccgag taccacaaca tcaccgccgc ggcggagtac gcccgcgagc
    17761 acgggtggca ctcgcacgcc tggcagatcc cgtgcgcgat gcaacccctg ctggccggga
    17821 tgaactacgg cgagcgggcg tacgtgctct tcgagggcgc cgtgtccgcc gccaccgcgg
    17881 cggggcacgc cgacgggcga tccatggccc tgaccggcat ggcgtcggtc tgccgggaag
    17941 ccggtgacaa tgaccaggcc cgagcgctgt tcgaggaggc gatcgcgatc agccgggcga
    18001 ccggcaacgg ccgccatgag gtcttccagc tggcgggcct cgggatcacc ctcctgaacg
    18061 acggcgacct tccggccgcc gagaaggtgt tcgcaaccgg ttaccgggcg gcgcgcgagc
    18121 tgcacgaccg cgcgaccgcg gccctcctcg cgaacaacct cggcgtagtg gcgaaggacc
    18181 tgggcaacta cgccgacgcc ctccggtact tcaccgagtc ggccgagcac ggcaacggct
    18241 tctcgaccga ggacatcgcc atcctgaccg cgctgaacat cggcatcgtg caccagctgc
    18301 gcgacaatcc ggaagccgct acccggcagt acgaggagtg ccggcggcgt agtcgcgcca
    18361 tcaagttcga cgtcggggag gcggtcgccc tggtcggtct ggcgacggtg aatcgctcgc
    18421 tcggcaattt cgcggccgcg ttggaggacg gccgcgatgc cctcgccatc gcgcgtcgga
    18481 ccgcgctgcg ggaggtcgag tgcgacgcac tcaatgccct cggcgacatc ttcctctcga
    18541 ccggagaagc gagtagcgcg gaaacgctct tcgcccaatc cgaacagctc gccgtcaggc
    18601 acaaccttcc gcgcaacgcg gcacgctcgc gtgaggggat cgcgcacgtc cgcttcgccg
    18661 aaggtgacct ggccgccgca cgacgggact gggaggaggc cgtccgtctc ttcccggccg
    18721 gtgtcgcgga cgcggagaac tcgcggcggc acctgacatc cgacaccgtc ctgcagccgc
    18781 gatgccagcg ctgcgtcgtg gtcgcgcgta cggccgcccc gtccttccgg tccgagtagc
    18841 cggcgagtag ggcaccgata ccgatatctg ccaccatgat cgaagtccgt gcaataccta
    18901 tcgatatgat gcggttcgcc gcgtcgaagg agagtcacca gtaatgaagc ggaatgtctt
    18961 tctcgcgatc ctgggcgccg gcgtgctgct ggccctcatc cccggcgtga gcgggagcga
    19021 ggcgcccgtg gcgaagcggg ccagcatgat ggtcacctgc gggagctgcc cctgacgccg
    19081 ggcgcctcgg cgcgggatcc gtggtagcga tcagggaggc agcagatggg ccatgagccc
    19141 ggcgaagaca ggcgagcttt cgcgttcacc gcaaccgtgc tcgccgtgct cctcctggcg
    19201 gccctcctgg cccagctgcc gcccggatcc atgccgcaca ccctcagccg ccgagcggct
    19261 tcgtacgagt tgctgtggcc acaggggtgg tccttcttct ccgcggcacc ccgccaggac
    19321 cggaccgtcg cgtaccgggt ccagccggac ggcagcctct ccaccgagga ttccgtgcag
    19381 gcaaggcccg ggtcctggtg ggggctgcgc cggaccacgt acttccgcct ggtcgaaacc
    19441 gagtacgtgg catcccggat ccccccgtcc tcgtggatca cgtgtgatgc cccgacggcc
    19501 gcgtcctgtc tgcagcgggc aggccggccc gcatggcccg tgacgaacaa tccgttccac
    19561 gcctccgcgc tgtgcggacg ggtcctcttc gcggtggagc ggccggacct cggcaacgat
    19621 cggctccggc gaggagccgt cccgcggcgg gtggtcgcca tcgcgccgac ctcgctgcag
    19681 tgcgcccccg accggaagta gcgatgatcg accctctgcg gcacctgccg gcctacgacc
    19741 cgagagggct ctggctggcg tgcgcacgaa gcatgttcgc ggcggcgacg ctgtccatca
    19801 tcgtctgcaa cccggacgac gtgctgttcc ttcgcgtggg cgaccagtcc gccgtcagat
    19861 gcgggggtgt ccagggcttg tcgctctggt gcctcggaca ggtcggcgac ggcgacctga
    19921 gcctggcccg catcgtctcg gtactcgtgc tcgggctggt cgttgtcggc ttccgtccac
    19981 gctggacctg catcccgcac tggtacgtca cctacagcct ctgcgtcagc atgacgctgc
    20041 ccaacggggg cgagcacgtc gcacagatcg ccaccatgct gctgatcccg ctgtgcctcg
    20101 gcgaccaccg cacatggcag tggcaatctc cggtgaccgc cctgcacgcc agctggcgag
    20161 gcgcgagtct cgccgcgatg tacgtgttcc gggtgcaggt ctgcatcatc tacgcccacg
    20221 cggcgtggtc gaagctcatg gagcagagct ggcgggacgg caccgccgag tacgtcatct
    20281 tcttcgatcc gcactacggg ccctatccac ccgtgcgcga ggcgctcctg cccgtcctct
    20341 cctcaccatc ggtgatcgtg gggctgacct ggtccaccat cgggatggag atcgccatcg
    20401 ccgtcctcgc cctgggcacg cggcggatga gactcgctgc tctcggcctc gcggtactcc
    20461 tccacggggg catcatcgcc ctgatgggta tgcccagctt cgggctcatc atgatcgcgc
    20521 tgctcaccac gaacgccgtc gccggcgcga atcaggccgg cccggcaccc actcactcga
    20581 agggatcccc ggttgaccgt gacaacgtcg ccgttcaccc cggatgacgc cgccgagaac
    20641 gagctcgccg attactacca gctcgcgctc gccgacgcgc ggacggagcg tccggacgac
    20701 cccgagccga cgtacgaggc ggcgatcgga cgcttgcgta cgcctctcac cgccctcggc
    20761 cgatgcgtgc accgagcagc gtacgccgac ggccggctgg tcggattgat cagcgccggc
    20821 ctgcccgagg acgagaacgt cgagcaggcc gtcgtggacg tgaaggtcca ccccgatcac
    20881 cgccgccggg gcatcggcac cacgctcctg cgtacgctgc tgcccaccct ggcatccgaa
    20941 cgccggacgc tgctggccgg ttggggcctg atcgagggca agtccggtgc gagctgggcg
    21001 aagcgccgtg ggttccgtgt cgtctaccgc caggtcctgc aggggctcga cgtcgtggcc
    21061 accgaccggg agctctggcg cgtggccgcg ccagagggct accggacggt gcagtgggtc
    21121 ggcaccgcgc ccgccgagct gctcgcctcc tacgctgagg cgcgcagtgc catccatgac
    21181 atgcccagcg ccgactggag ctaccgtccc ccgacgtgga cgccggagcg gatccggcgc
    21241 gcggaagccg agctccgcga gcgcaacgtg gagcagcggg tcgtcgcggc ggtccacgag
    21301 gagaccggca cggcggtcgg cttgaccgag ctggagttct acccgcaccg cccggacttc
    21361 ggctatcagc aggagaccgc ggtgctcgcg gggcatcgcg gccgtggcct gggccggttg
    21421 atgaaggcgc ggatgatgga ctgggtggtc caggagcgac ccgggacaac gcacgtctgg
    21481 acgacgacgg ccgacgacaa cgtgcacatg aggcgcgtga atgagcagat cggttacgcc
    21541 acgatccgcg tcatggtcaa cgtcgaggtc gagaccgacg ccgtccagct ctgaaccggc
    21601 ggacgccgca tcggctcacg ccgggccgca caccgcgtat ctcgacccgc acatgacgat
    21661 caaggacgat gaccacccgt gcggcgacga tcacgcgtac cccgagtgga agcgcgactc
    21721 gaagctcacc gtgtatttgc ccaccgcccg atcgacgtgc tcgccgggcg taccgccgag
    21781 acgttcgctg cgtggctgcg cgcacatccc ggcatggcgg tgctatgcga gttccgggaa
    21841 gcaccagccg gccagatgcc gcaggtcctt ggcgttgccg atcggcaccc ggtccggcgc
    21901 cgggcggtcg tcgggcggcg tgggcacgtc acgcgcgacg cgtcgtacgc gcggtgtccg
    21961 gtccaggtgt gaggtccact gctgccagcg tccctcgtga cggccccgga acccgcggcc
    22021 ctcgacgtcg tccgccgtgg gtggacgggc gaagaggccg tcgaggtact cgacgaggcc
    22081 gtaccaccgg ccgtcgcggt cctgcatctc atggcagaag gccaggatcc aggcgtcctc
    22141 acggcactgc acggcgtaga tgtcgccggc tcggggttcg ccgcgcagcg cgggcggcag
    22201 cggagcggcg cgttcgaccg cggtgcggcg cggtgaaacc gggggcggtg ggtgcgggcg
    22261 ctcgtccggc cgggcgagat ggccgaacag ccggtccacg agggattcgg tgacgccgtg
    22321 cgcggcgctc cagaacgaca gcggggcgct cacctccacc cggacgctgg gacgttcgtc
    22381 gcgctggcga gccgtggtga aggccgtgaa catgcc
//
