LOCUS       NZ_CP023865            20546 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6785660
            Orig. end                         :: 6806206
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20546
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="23"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20546
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20546
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10546](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10546)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(489..505)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.64"
                     /tool="antismash"
     misc_feature    complement(1721..1735)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.44"
                     /tool="antismash"
     misc_feature    complement(1832..1846)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 29.02"
                     /tool="antismash"
     misc_feature    1833..1847
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 29.02"
                     /tool="antismash"
     gene            complement(<3159..>3383)
                     /locus_tag="ACTEI_RS29745"
                     /pseudo=""
     CDS             complement(<3159..3383)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183161.1"
                     /locus_tag="ACTEI_RS29745"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFEIAIAAAWRYVQDAIVLLRAAADDLDSAMRRIRQLAYAILDGT
                     LIPTDRVADHRPYHSGKHRRHGVNVQVIAD"
     gene            complement(3482..4492)
                     /locus_tag="ACTEI_RS29750"
     CDS             complement(3482..4492)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287898.1"
                     /locus_tag="ACTEI_RS29750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_122980673.1"
                     /transl_table=11
                     /translation="MARPITLFTGQWADLPFDEMCRLASEWGYDGLEIACWGDHFEVDK
                     ALADDGYVERKRELLAKHNLQVFAISNHLVGQAVCDHPIDERHRDILPARIWGDGEPEA
                     VRRRAAEEMKDTARAAAKLGVNIVVGFTGSSIWHTVAMFPPVPAEMIERGYADFAARWN
                     PILDVFAEVGVRFAHEVHPSEIAYDYWTTRRTLEAIGNRPEFGLNWDPSHFVWQDLDPV
                     NFILDFADRIYHVDCKDAKVRTGDGRRGRLSSHLPWADLRRGWDFVSTGHGDVPWEDCF
                     RALNAIGYAGPLSIEWEDAGMDRLVGAPEALSFVRRLAFDAPAAAFDTAFSSAKA"
     gene            complement(4779..6881)
                     /locus_tag="ACTEI_RS29755"
     CDS             complement(4779..6881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007463794.1"
                     /locus_tag="ACTEI_RS29755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThuA domain-containing protein"
                     /protein_id="WP_122982492.1"
                     /transl_table=11
                     /translation="MRKPFRSLLGVATAALTTLACTVTPASAADPAYDVLVFSKTAGFR
                     HDSIGAGVQAIKDLGAANNFTVTATEDAATFTTSDLAGYETVVFLNTTGDVFDATQRTA
                     FESYIRGGGGFAGVHAAADTEYNWPFYGQLVGAWFASHPSIQQADIKVEDRAHAATAHL
                     PQTWTRTDEWYNYKTNARSTAHVLASLDETSYSGGGMGGDHPHAWCKTLDSGRSFYTGG
                     GHTIASYADPGFRRHLLGGIRYTAGRAQADCRPETGYTPLYNGSTSGWSQAGPGSFTNS
                     DATLTSVGGLGMLWYSAKAYTNYSLKLDWRMSGDDNSGVFIGFPASSDPWSAVDNGYEI
                     QIDATDSADRTTGAVYSFQGANTAARDAALNPPGEWNTFELLVEGQRLQIFLNGVKIND
                     FTNTNPARNLDGYIGLQNHGTGDEVSFRNVRLKELNGGGGGARTLEAEAYTSASGVQPF
                     TKSGAHNGQTLGYIDPGDWSSYSGVDLTGITTFTARVVSGGAGGTIQVRTGSATGTVLG
                     SVTVPNTGSWGTFADVTTTLSAVPSGTRTLYLTYTGSGSGLFDVDDFTLDASGGGTATG
                     PVAGFAGKCLDVDAGGSADGTRIQLWTCNGTGAQTWTVDGQVWRNPQSNKCLDVAGGAT
                     ANGTKAQLWTCNGSAAQNWVAQPDKTVKNPQSNKCLDVSEAKSTDGQQIHLWDCHAGAN
                     QLWTLP"
     gene            complement(6955..9783)
                     /locus_tag="ACTEI_RS29760"
     CDS             complement(6955..9783)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007463796.1"
                     /locus_tag="ACTEI_RS29760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_122980674.1"
                     /transl_table=11
                     /translation="MQSLRGRSSRFRWCAAAASSLLVAAVTVVGSATAVQAHPIDATDF
                     AQITLAKGEPEVGEPLTLAVLPDRSVLHTARNGTLRRTDSNGNTAVVGTLAVYSHDEEG
                     LQGVGVDPYFSTNRHIYLYYAPPLSTPGGDAPSTGTDWSAWQGVNRLSRFTLTSDWKLS
                     AETKILDVPADRGICCHVGGDIDFDAAGNLYLSTGDDSNPFQSNGYSPLDERANRNPAF
                     DAQRTAGNTNDLRGKILRIKVNADGSYSIPAGNLFPQGTARTRPEIYAMGFRNPFRMSV
                     DKATGVVYVGDYGPDAGSTSSRGPSGQVEFNRVTGPGNYGWPYCTGTNTATETYAEWDF
                     DAGTAGAKYDCTGGPANNSFRNTGRSTLPPAKAAWIRYAGDAGSPPEFGGGSESPMAGP
                     VYRYNASSTSTTKFPQSFEGHFFAGEFGRGWIKPVHVGSDGSVGEIATFPWNGKQVMDM
                     AFGPDGSLYVLDYGTGYFNGDENSALYRYDYVGSGNKSPTANVTADKVSGQAPLTVTFS
                     SAGSSDPEGSALTYSWNFGDGTTSTSANPAKTFTSNGTYNVTLTVTDAQGATGSAGVQI
                     GVGNTAPTVTISTPGNGRLFDFGDTIPYTVTVTDPEESAIDCSKVKMTYVLGHDQHGHQ
                     ISSTTGCSGSVTIPVDGEHDAAANIFAVFDAEYTDAGGLATHTQHTLQPRHRQAEHYKN
                     ASGVTVYGKVAAEGGKTVGDISNGDWISFEPYQLSNATSFSARVSSGGAGGTLQLRAGS
                     ATGPVLGSATVPVTGSWETFTTVSGTIASPPAGTTTLLLTFAGGSGALFDVDAFTFTTG
                     SAARTGPVAGFAGKCLDVDAGGSADGTRIQLWTCNGTGAQTWTVDGQVWRNPQSNKCLD
                     VAGGATANGTKAQLWTCNGSAAQNWVAQPDKTVKNPQSNKCLDVSEAKSTDGQQIYLWD
                     CHAGANQLWTLP"
     misc_feature    complement(9944..9962)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.06"
                     /tool="antismash"
     gene            complement(10001..10546)
                     /locus_tag="ACTEI_RS29765"
     CDS             complement(10001..10546)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="ACTEI_RS29765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_239082083.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.5e-19, bitscore:
                     67.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFCYWGRRSAGGEECAPIVTAAAALELFHAFALIHDDIMDGSERR
                     RGEPSVHQLFADPHTRSSWRGDAARYGRNTALLCGDLCAAWADEMFQGCGLTREQVYRG
                     YAVFAGMRTEIIAGQYLDLVSSVGDGSAASALTVIRMKTARYTVTRPLQIGAAPVPAQV
                     AAALTALAEEATNRPHRQ"
     gene            complement(10787..12172)
                     /locus_tag="ACTEI_RS29770"
     CDS             complement(10787..12172)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475570.1"
                     /locus_tag="ACTEI_RS29770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotide pyrophosphatase/phosphodiesterase
                     family protein"
                     /protein_id="WP_122980675.1"
                     /transl_table=11
                     /translation="MSKLVVLDVVGLTPRLLAHMPRLRAVADGGFSARLDPVLPAVTCS
                     VQATFLTGERPAGHGVVGNGWYFRDLGEVLLWRQHNALVGGEKLWHTARRRRPGFTVAN
                     ICWWYAMGADVDWTVTPRPIYRADGRKDPDCYTDPPELHDELTARLGAFPLFSYWGPGA
                     GLASSHWICRAAEQVMAAHDPDLTLVYVPHLDYDLQRYGPADPRAAAAAAALDAVLGPL
                     LRAAVARGATVVALSEYGITPVQRPVHVNRALRAGGLLRVHRQDGMEYLDPWTSRAFAV
                     ADHQVAHVYVRQPADLPYVTELLTGLPGVADVLNAEGKRRQGLDHARAGELVLVAEPDA
                     WFTYYYWLDTARAPDFARLVEIHRKPGYDPAELFFDPAAPGAAKRRAVLALARRKLGMR
                     YLMNVVGLDAGAQAVRGSHGRLPGDPADAPVLLCSDASAARTRLAATDVKGVLLELAGL
                     EGE"
     gene            complement(12169..13332)
                     /gene="eboE"
                     /locus_tag="ACTEI_RS29775"
     CDS             complement(12169..13332)
                     /codon_start=1
                     /gene="eboE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018783818.1"
                     /locus_tag="ACTEI_RS29775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metabolite traffic protein EboE"
                     /protein_id="WP_122980676.1"
                     /transl_table=11
                     /translation="MRLRHVSGGTVHVSYCTNVHPAEDLPGIVRQLDAYAVPVRQRLDV
                     GVLGLGLWLAAPVAAALARDAGSRRRLRAELDARGLEVVTLNGFPYRAFHAPVVKHAVY
                     HPDWTTAERLDYTLDLARVLVDLLPGDVRRGSISTLPLAWRKPWRPDQHEAALAMLDRL
                     AGGLAEIGRDSGREVRVGFEPEPGCVVETTAQAARLFSAVDRDRLGVCLDLAHLACAWE
                     EPAAALDRLAAAGLPVVKVQVSAALEVTDPVAARQVIGPYAEPRFLHQTRSAGGAGTDD
                     LDLALAEDLPGPWRVHFHVPLHAAPAVPLASTTPVLEAGLRELMTAAEPWCDHLDVETY
                     TWDVLPPDRRPGTAAELADGIAGELAYTRDLLGDLGLRPAGPVEANR"
     gene            complement(13332..14183)
                     /locus_tag="ACTEI_RS29780"
     CDS             complement(13332..14183)
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007463803.1"
                     /locus_tag="ACTEI_RS29780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TatD family hydrolase"
                     /protein_id="WP_122980677.1"
                     /transl_table=11
                     /translation="MRIFDPHIHMTSRTTDDYERMAAAGVQAVVEPAFWVGQPRTNAGS
                     FADYFDSLVGWEPFRAAQFGIRHHATIALNPKEANDPHCREALSLVPRYLDKDSVVAVG
                     EIGYDAMTPEEDEVFAVQLRLAVEYALPALVHTPHRDKARGVSRTLDVVRESGIEPGLV
                     VVDHLNEVTVGAVHDSGCWMGFSIYPDTKMSPSRMVEILRGHGLHRMLVNSAADWGRSD
                     PLLTRRTGEAMLAAGFTDDDVDQVLWRNPVEFYGQSGRPHLTATAPGPASFQGSSILRG
                     GS"
     gene            complement(14153..14791)
                     /locus_tag="ACTEI_RS29785"
     CDS             complement(14153..14791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475567.1"
                     /locus_tag="ACTEI_RS29785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EboA domain-containing protein"
                     /protein_id="WP_122980678.1"
                     /transl_table=11
                     /translation="MDPDTLRTALHDCCGGAWLAAGVARVSADPPSITRLFPAAGRRCG
                     RSRLPEASDWTADEAARALLLLALPRTDLPRYLDELYRYGDAVEKHAVLRALALVPIGA
                     EAVPLLHDAIRTNDTRLLSAALGPYARHLDQRAWRQAVLKCVFLGVPLSRVHDLTRRAD
                     RELVAMMAGLREEREAAGRHLPADALALVRQFTRPVLEVRCASSTRIST"
     gene            complement(14847..15686)
                     /locus_tag="ACTEI_RS29790"
     CDS             complement(14847..15686)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072426.1"
                     /locus_tag="ACTEI_RS29790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_239082084.1"
                     /transl_table=11
                     /translation="MTGLRFGYGTNGFANHRLTDTLTILADLGYHGVALTLDHGHLDPF
                     APGLARRVDAVAADLARLGLSLVIETGARYLLDPWEKHAPTLLHDERELRIDFLRRAVA
                     VGADLGAEAVSFWAGVRPPGVDERTAWQRLVGGCADVVAAAEEHAVVLGFEPEPGMLVE
                     DIAGWRRLHDALGSPARFGITLDIGHCRCREPEPVPDCVAAVADHLVNVQIDDMRRGVH
                     EHLPFGTGEIDFPPVLAALHAAGYRGLVAVELPRHSHAAPAVAARSIQFLKAAARRG"
     gene            complement(15683..16048)
                     /locus_tag="ACTEI_RS38735"
     CDS             complement(15683..16048)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS38735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_239082093.1"
                     /transl_table=11
                     /translation="MLSRAEVHGAKASLPVRTLAATAAVAGLAGSTRPGPGTRLRRTLV
                     PAALAGWYAARYGAVQAAVIGDPSAARVRAAVGAGITTLPVLQGALTARQGAVAAGAAT
                     ACVAELAARLARAVSPT"
     gene            complement(<16186..16560)
                     /locus_tag="ACTEI_RS38740"
                     /pseudo=""
     CDS             complement(<16186..16560)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="ACTEI_RS38740"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="UbiA family prenyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTGWRDLIELTRAPAALSVPGDAVAGAAAAGTLRPRTLALAGASV
                     CLYWAGMAANDWADRHLDAVERPDRPIPSGRVPATTAVGLAVGLTAAGMAVAGLAGGRR
                     RLPVALALAGAIWAYDLGAKN"
     gene            complement(16557..17705)
                     /locus_tag="ACTEI_RS29800"
     CDS             complement(16557..17705)
                     /GO_function="GO:0004512 - inositol-3-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006021 - inositol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475564.1"
                     /locus_tag="ACTEI_RS29800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="inositol-3-phosphate synthase"
                     /protein_id="WP_122980679.1"
                     /transl_table=11
                     /translation="MTVGVWLVGGRGSVAVTSIVGASALRAGLVPGTGCVTELPEFRAA
                     GLAGFGDLVFGGHDRVSTPLTKRAGELAASGVLPAALVRAVHDDLVRADADIRLAPAGE
                     SQAETAATLQADLRDFRDRYGLDRVVVVNVSSTEPLAAAHPAHATAADLNVALRRGEAV
                     LPPSALYAYAAFSAGCSYVDFTPSTGARLPALAEIARRRGLPYAGNDGKTGETLLKSVL
                     APMFARRHLHVRSWSGVNLLGGGDGATLADPGANAAKSASKQRVLKETLGYQPQGAVRI
                     EYVEDIGDFKTAWDLVTFSGFLGTGMRLEFTWHGCDSALAAPLVLDLARLTGAAHAAGR
                     VGPLHELAFFFKDPLGDVAHGFAEQWQALTAFAAGLGAESPA"
     misc_feature    17717..17737
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.68"
                     /tool="antismash"
     gene            complement(18158..19378)
                     /locus_tag="ACTEI_RS29805"
     CDS             complement(18158..19378)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287909.1"
                     /locus_tag="ACTEI_RS29805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_122980680.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.4e-26, bitscore:
                     91.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 4.1e-31,
                     bitscore: 106.3, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHTTDLRVGMIGYAFMGTAHSQAWRTVNRVFDLPMQARMAVVC
                     GRGEAKVAEAAAQLGWQEHTSDWRALVARDDVDLIDICTPGDSHAEIAIAALDAGKHVL
                     CEKPLANTLDEAQAMAAAAARAAALGVRSMCGFNYRRVPAVSLMRRMIAEGRLGEIRHV
                     RAVYLQDWITDPEFPLVWRLQKDKAGSGALGDIGAHIIDLTQYVVGQRIAGVSALTETF
                     VKHRPLPGASSGLSAAASDGSGGGPAGRGEVTVDDAALFLARLDGGAIATYEATRFATG
                     RKNGLRVEINGSRGSLVFDFERMNELEFYDATLPAAEQGFTRILVTEPTHPYMSGWWPP
                     GHLIGYEHSFTHQARDLIEAIATGADVAPSFADALQVQLVLDAVVRSAQLGSTWLEVKS
                     APTEAIA"
     gene            complement(19400..20452)
                     /locus_tag="ACTEI_RS29810"
     CDS             complement(19400..20452)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072429.1"
                     /locus_tag="ACTEI_RS29810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_122980681.1"
                     /transl_table=11
                     /translation="MSQHSRDLSRRRLLLGGAALGAGTFLTACTSNEAQPTQAQTKDVA
                     AGGNAAPGEKVVIGFSAPAADHGWIAAITNNAKAQAATYTDVEFKSVEAGADAAAQRAA
                     LSTLIAQKPQVIVLLPHDGKELNAFGLEAMAAGIPVVNLDRAFPDARAYRTQIKGDNYG
                     MGVAAAAYIIAQMKARGVSSPVIGEIPGIDSLELTQERSKGFADTLNAAGFKVQRRVPA
                     EFTADTGQRAASQLLQALPKLDALWNHDDDQGIGVLAAANQAGRKEFIMVGGAGSKKAM
                     GDIQTDNTPLKATVTYSPSMASSAISLARLIGQNKGMADLVELQVPKELVLASETITKE
                     NASKYLKFGF"
ORIGIN
        1 tcgacaccgg gtgcagttcc cgctgctccg ggtcgtcctc gggcgacatc gggatgccgg
       61 tccagttggc gtcgtggatc ttgtggtgcg ccatcccggc gaacggcttg ccggccggca
      121 cctgcatccg catcaggaac tccagctccc agcgggcctc gtcgaggatg tccggtaccc
      181 tgttgccacg ctccggcacc cgcagcgtgc tgtccgccag cgcggcgccg tgcccggccg
      241 tgggcgcggt cttggtgcgc tcgaacgtgc tcatcagctg ctgcacggcg ataccaccgt
      301 tgaccacgta cttgccgtgg tcgcccgcgt cgtaccagcc accgcggacg tccagccggt
      361 agtcgcaggt atcggcacgg cacggcacgt cgacgtcgcc gcggttcggc gcgatgccga
      421 catgtccggc ggggcgggcg tactccgcac cgaccaggtc accctcgatc tcgatgccac
      481 tgcgctggat gtagaagaac tgcagcgcat cggaacgcag ctgccggtag acggtgccgg
      541 agatgtcgaa cgggtggctg gtctgcccgt cggcgaccag ccggtatccg gttccggcag
      601 cgcggaagga gctgaagtcg atgctgtgca cgttctgccc ggacgccgcg tccactccgc
      661 gcggcgtgct gctgccgctg gcgaccacgt cgccctcgga gttcttcagc tgccagccga
      721 gggcgtcggt ggcgtcggtg accaccgtcg cgttcttggg cccggcgggc aggtagccga
      781 cctggttgac ccggacccgc ggtccggtct ccggcacgta gggcggctcc tcctccccac
      841 cgaccaggga gacattgtcc agacagaacg tgtgcccggc cgcgtttcca cccagctgga
      901 aggcgacctg gccggcggtg gtgtcggtgg aggcggtgaa ggtgtactcg aagtgctgcg
      961 ggctcgcggt cagcgcgacg tcacgagaca ggaacgaggt gtacggctcg gcgccgagct
     1021 gcacgttcgc gcggaccgtg gcccccggcg tggtggaggc gtcgaacgcg aacgtgtagg
     1081 acgagcccgc caccagcgag atcccgttct gcccgaggcc ggcgtcccag gggttggcca
     1141 gcccggccgg caccgccgag cacagccgcc cgtcgtccac cccggtggac gtggtgccgt
     1201 acgagtacca gcccgacgtc ccctcggcga agtccccgtt ctcgatctgt tccgggccgt
     1261 ccggcggcgg cacggcgtcg tcgctggtca ggctgacgtc gtccaggcag aaggtgaagt
     1321 cgtcggcgct gccgccgagc tggaaggtca gcgtgccgtt gggcgagtcc agcccggccg
     1381 tgaactcgta ctcgaaggtc tgcgcctcgg cggtgagcgc gacggcacgc gacagcgccg
     1441 gggtgtaggg cgcctcgttg agctggacgt tggcgcggac gctgacctct tcgctggccg
     1501 acgcacggaa gctcagagcg tactcggccc cgtcgatcag cgggacgtcg ttgtggccca
     1561 gactgacgtc ccaggcgttg gtggtcccgc cggggatctg agcgcagagc tgcccgtcga
     1621 cgatcgatat cggtgcgttg tcggtggacc accacccggt ggtgccagag ctgaaggcgc
     1681 cgttggggat gtgctggacc ggctcggcgg aagcgggcgc agctgtcaga aaagtcagcg
     1741 cgaaggtggt cgcggcccct gccgcgagcg aggcggtgac ctgtcgccgt cgatgtggat
     1801 tcacagacgt ccttccagtg gcatcaccat tctgggagcg ctcccagaca gggctgattg
     1861 ttgccagcga attaacgcct gtcaatcgag acgagtcgat caggccgggc cggcggggtc
     1921 accggtcgac accgtcatgc ggtcaacgat ctgccggtgg ccgattcgcc atgcggtaca
     1981 gcttccgggc ccgggcgatg tcaagcgaca tgccgtcgtt cacgggcagg acccacgggt
     2041 cggtcgccgg cggatagcca cggattgtca tgggccgccg caatggtgcg ctcatgcccg
     2101 aagagtagcg acgagccggc cagcggccag acaacgagca ccctgagtaa cagggtggca
     2161 tcgacggttt ctcggtgccg gccgcgctgg gtcgcttcct gttcgcggcg gcaggtggcg
     2221 ttgccgtggg cgtgctgatc gccttcgcgg tgcgcctcct ctcccggccg ctgagtggcg
     2281 atccggtgat ggccgagttg gcccagtcgc tacccggctc gtggcacacc tggctcgacc
     2341 acgaggagcg attgctgccc gaccgaccgg cccgccggtg agctgcccgc accgtgcggg
     2401 gcggccgggc cggtgcggcc caggcgcagc agcaggtacg ggttgccgac acttgcgatc
     2461 atcgcccgca tcgcttgccg gctcgcgatg acctcgatcg gcgcactgta cggcaccacg
     2521 ccgataccgc ggccggtagc ggtgagccaa ccggcggaca aggcctcgcc ggcacgcaac
     2581 cagtcgaccg ggtcgtcgct gcggccgaag agcacgacga ataccgcccc ggtgtcatgt
     2641 ccggcgcgga ccgatgatgc cccacgacgg cccgagtcgg ggctcgacgc cagggcgggc
     2701 gttgcccgtt cggggacgcc ggagccggac gggcgggtgc ctcccgccca ggcagccagt
     2761 tccacctgcc aggcgggggc cgccgctccg atgcgctgcg cgtggtagac cgccgaggcc
     2821 agttccagga tctgatcggc tcgcagggtg tgcagctctg tctcctgggc acgcatcgcc
     2881 gcgacgacgg cagccaggtc caccgggtcg atcggcgtgc cgatgatcgg acgtcggtcc
     2941 gtgtgccgca acaagatgag tcggaggaag tccagcgacg ccgggtcggc cggctcccgt
     3001 ccgctgactc ggacccgggc gagcacatcc gcgatcgcgc gcaccatgct tgcgggctcc
     3061 ggacaacttc ctccgagcaa cgaccgcgat ggacggcacg atggcgggcg gcatgatcgg
     3121 ggcgcccggt tgaccgccct ctgcccacgt ccggtcacgt cggcgatgac ctgaacgttg
     3181 acgccgtgac ggcggtgctt gccggagtgg tacggcctgt ggtcggcgac ccggtcggtc
     3241 gggatcagcg tgccgtccag gatcgcgtac gccagctgcc ggatgcgccg catcgcgctg
     3301 tcgaggtcgt cggcagccgc tctgagcagg acgatcgcgt cctggacgta gcgccaggcg
     3361 gccgctatcg cgatctcgaa gccggtttgt cgcgtgggag gtaaagcggc agccggagat
     3421 cggcggcgca cgtgcgcggc cggactgatc gcgccgcgcg gacgactccc ggtgaccggg
     3481 actacgcctt ggcggacgag aacgccgtgt cgaaggccgc cgccggcgcg tcgaacgcca
     3541 gccgccggac gaaactcaac gcctccggcg cgccgaccag ccggtccatc ccggcgtcct
     3601 cccattcgat ggagagcggg ccggcgtaac cgatggcgtt gagcgcccgg aaacagtcct
     3661 cccacggcac gtcgccgtgg ccggtggaga cgaagtccca cccacgccgc aggtcggccc
     3721 agggcaggtg ggagctgagc cggccgcggc gcccgtcgcc ggtgcgtacc ttcgcgtcct
     3781 tgcagtcgac gtggtagatc cggtccgcga agtcgaggat gaagttgacc gggtcgagat
     3841 cctgccagac gaagtgcgac gggtcccagt tgagaccgaa ctccggccgg ttgccgatcg
     3901 cctccagcgt tcgcctggtc gtccagtagt cgtaggcgat ctcgctcggg tgaacctcgt
     3961 gggcgaaacg gacacccacc tccgcgaaga cgtcgaggat ggggttccac cgcgcggcga
     4021 aatcggcata tccccgttcg atcatctcgg ccggcaccgg cgggaacatg gcgacggtgt
     4081 gccagatcga cgatccggtg aagccgacga cgatgttcac gcccagcttg gcagcggccc
     4141 gggcggtgtc cttcatctcc tcggcggcgc gccgccgcac cgcctcgggc tcgccgtcac
     4201 cccagatccg ggcggggagg atgtcgcggt gccgctcgtc gatcgggtgg tcgcagaccg
     4261 cctgcccgac caggtggttg gagatggcga acacctgcag gttgtgcttg gccagcagct
     4321 cgcgcttgcg ctcgacgtag ccgtcgtcgg cgagcgcctt gtcgacctcg aagtggtcgc
     4381 cccagcaggc gatctccagg ccgtcgtagc cccattccga ggccagccgg cacatctcgt
     4441 cgaacggcag gtcggcccac tggccggtga agagggtgat cggtcgcgcc atgttctcac
     4501 ttcctcgcgg gtgtcccggg actgtgtgcg ggattccggt gccgtcgagc ggcggggcgg
     4561 cacgagggac cacccgaaga tgacgacgcg gcagcgagac gacgcgagca tgccgagtgg
     4621 gcttgcgcct cccacccggg cgccgctgcg cgtccgcgat cgttgaccat cactctaggc
     4681 ggcccgcggt gccggcggta gatcagccgc ggtacggggt tgcgccgcgt acccgatgcc
     4741 cgggggcacc cgggtacgcg gcctcatcgg tggtcacgtc agggcagggt ccacagctgg
     4801 ttggcgccgg cgtggcagtc ccagaggtgg atctgctgac cgtcggtgga cttggcctcg
     4861 gagacgtcca ggcacttgtt cgactgcggg ttcttcaccg tcttgtccgg ctgggccacc
     4921 cagttctgcg cggcggagcc gttgcacgtc cacaactgcg ccttggtgcc gttcgcggta
     4981 gccccgccgg cgacgtccag gcacttgttg gactgcgggt tgcgccacac ctgaccgtcg
     5041 acggtccagg tctgcgcgcc cgtgccgttg cacgtccaca actggatcct cgtgccgtcg
     5101 gcactgccgc cggcgtcgac gtccaggcac ttgccggcga agccggccac cggcccggta
     5161 gcggtgccgc cgccggacgc gtccagggtg aagtcgtcca cgtcgaagag cccgctaccg
     5221 gatccggtgt aggtcaggta cagggtgcgg gtgccggacg gcacggcgga cagggtggtg
     5281 gtgacgtcgg cgaaggttcc ccagctgccg gtgttgggca ccgtcaccga gcccagcacg
     5341 gtgcccgtgg cggatccggt gcgcacctgg atggtgcccc cggcaccgcc ggagacgact
     5401 cgcgccgtga aggtggtgat cccggtcagg tcgacgccgc tgtaggagct ccagtcaccc
     5461 gggtcgatgt agcccagcgt ctggccgttg tgggcgccgc tcttggtgaa cggctgcacc
     5521 ccgctggcgg aggtgtacgc ctcggcctcg agggtccggg cgccaccccc gccgccgttc
     5581 agctccttga gccgaacatt gcggaacgac acctcgtcgc cggtgccgtg gttctgcagg
     5641 ccgatgtaac cgtccaggtt gcgcgccggg ttggtgttgg tgaagtcgtt gatcttcacg
     5701 ccgttgagga aaatctggag tcgctggccc tccacgagca actcgaaggt gttccactcg
     5761 cccggcggat tcagcgcggc gtcacgagcg gcggtgttcg cgccctggaa gctgtagacc
     5821 gcgccggtgg tgcggtcggc gctgtcggtg gcgtcgatct ggatctcgta gccgttgtcc
     5881 actgccgacc acgggtcgct cgacgccggg aagccgatga agacgcccga gttgtcgtcg
     5941 ccggacatcc gccagtcgag cttcagggag tagttcgtgt acgccttcgc ggagtaccac
     6001 agcatcccga ggccgccgac cgaggtcaac gtggcatcac tgttcgtgaa gcttcccggc
     6061 ccggcctggg accagccgga tgtcgagccg ttgtagagcg gcgtgtagcc ggtctccggc
     6121 cggcagtcgg cctgggcgcg cccggccgtg tagcggatcc caccgagcag gtgccggcgg
     6181 aaccccgggt ccgcgtacga cgcgatggtg tgcccaccgc cggtgtagaa ggagcggccc
     6241 gagtcgaggg tcttgcacca ggcgtgcggg tggtcgccgc ccatgccgcc gccggaatac
     6301 gacgtctcgt caagggacgc gagcacgtgg gcggtgctgc gggcattggt cttgtagttg
     6361 taccactcgt cggtacgggt ccaggtctgc ggcaggtgcg cggtggccgc gtgcgcccgg
     6421 tcctcgacct tgatgtcggc ctgctggatc gacgggtggg aggcgaacca ggcgccgacg
     6481 agttgaccgt agaagggcca gttgtactcg gtgtcggcgg cggcgtgtac gccggcgaac
     6541 ccgccgccgc ctcggatgta cgactcgaag gcggtccgct gggtcgcgtc gaacacgtca
     6601 ccggtggtgt tcaggaacac caccgtctcg tacccggcga ggtcggacgt ggtgaaggtg
     6661 gcggcgtcct cggtggcggt gacggtgaag ttgttcgcgg cacccaggtc cttgatcgcc
     6721 tgcacgccgg cgccgatgga atcgtggcgg aaaccggcgg tcttggagaa gaccagcacg
     6781 tcgtaggcgg gatcggcggc ggaggcgggg gtgacggtac atgccagagt ggtcaacgcg
     6841 gcggtggcca cgccgagtag agagcggaaa ggtttgcgca cggcgatccc ctcggctgag
     6901 cggttatgcg gcggatgggc cggtcccggc cgcacgccgg gaccggtggt cacgtcaggg
     6961 cagggtccac agctggttgg cgccggcgtg gcagtcccag aggtagatct gctgaccgtc
     7021 ggtggacttg gcctcggaga cgtccaggca cttgttcgac tgcgggttct tcaccgtctt
     7081 gtccggctgg gccacccagt tctgcgcggc ggagccgttg cacgtccaca actgcgcctt
     7141 ggtgccgttc gcggtagccc cgccggcgac gtccaggcac ttgttggact gcgggttgcg
     7201 ccacacctga ccgtcgacgg tccaggtctg cgcacccgtg ccgttgcacg tccacaactg
     7261 gatcctcgtg ccgtcggcac tgccgccggc gtcgacgtcc aggcacttgc cggcgaagcc
     7321 ggccaccggc ccggtgcggg cggcactgcc ggtggtgaag gtgaacgcgt cgacgtcgaa
     7381 gagtgccccg ctaccgcccg cgaaggtcag aaggagggtg gtggtgccgg ccggagggct
     7441 ggcgatcgta ccggagaccg tggtgaaggt ctcccagctg ccggtgaccg gcaccgtggc
     7501 ggagccgagc accgggccgg tggccgagcc ggcgcgcagt tgcagggtgc cgccggcccc
     7561 gccggaggag acccgggcgg agaacgacgt cgcgttgctc agctggtacg gctcgaagga
     7621 gatccagtcg ccgttgctga tgtcgccgac cgtcttaccg ccctcggccg cgaccttgcc
     7681 gtagacggtg acgcccgagg cgttcttgta gtgctcggcc tggcggtgcc tgggctgcaa
     7741 ggtgtgctgc gtgtgcgtgg ccaggccgcc ggcgtcggtg tattcggcgt cgaacaccgc
     7801 gaagatgttc gcggccgcgt cgtgttcacc gtcgaccggg atggtcaccg agccggagca
     7861 gccggtggtg gaggagatct ggtggccgtg ctggtcgtga ccgagcacgt aggtcatctt
     7921 gaccttggag cagtcgatgg ccgactcctc cgggtcggtg acggtcaccg tgtacgggat
     7981 cgtgtcaccg aagtcgaaga gccgcccgtt gccgggggtg gagatggtca ccgtgggcgc
     8041 ggtgttgccc acgccgatct gcacgccggc gctgccggtg gcgccctggg cgtcggtgac
     8101 ggtgagcgtg acgttgtagg tgccgttgct ggtgaacgtc ttggccgggt tggcggacgt
     8161 ggaggtggtg ccgtcgccga agttccagga gtaggtcaga gccgaaccct cggggtcgct
     8221 ggagccggcc gaggagaacg tgacggtcag tggcgcctgg ccggagacct tgtcggccgt
     8281 gacgttggcg gtcgggctct tgttgccgct accgacgtag tcgtaccggt acagcgccga
     8341 gttctcgtcg ccgttgaagt agccggtgcc gtagtcaagc acgtagagcg agccgtccgg
     8401 gccgaaggcc atgtccatga cctgcttgcc gttccacggg aaggtggcga tctcccccac
     8461 cgagccgtcg ctgccgacgt ggaccggttt gatccagccg cgcccgaact cgccggcgaa
     8521 gaagtgcccc tcgaacgact gcgggaactt ggtggtcgac gtcgaggagg cgttgtagcg
     8581 gtagaccggc ccggccatcg gagattcgga gccgccaccg aactccggcg ggctgccggc
     8641 gtcgccggcg tagcggatcc aggcggcctt cgccgggggc agggtactgc gtccggtgtt
     8701 gcggaacgag ttgttggccg gcccaccggt gcagtcgtac ttggcgccgg ccgtaccggc
     8761 gtcgaaatcc cactcggcgt acgtctcggt ggcggtgttg gtgccggtgc agtacggcca
     8821 gccgtagttg ccgggcccgg tgacccggtt gaactcgacc tgtccgctcg ggccccggct
     8881 ggaggtggag ccggcgtccg gcccgtaatc accgacgtac accactccgg tggccttgtc
     8941 cacgctcatc cggaacgggt tgcggaagcc catcgcgtag atctccggcc gggtcctcgc
     9001 ggtgccctgc gggaacaggt tgcccgccgg gatcgagtac gagccatccg cgttcacctt
     9061 gatccgcagg atcttgcccc gcaggtcgtt ggtgttgccg gcggtgcgct gggcgtcgaa
     9121 ggccgggttg cggttggcgc gctcgtcgag cggggagtag ccgttcgact ggaacgggtt
     9181 gctgtcgtcg ccggtggaca gatagaggtt gcccgcggcg tcgaagtcga tgtcaccgcc
     9241 gacgtggcag cagatgcccc ggtcggccgg gacatcgagg atcttggtct cggcggagag
     9301 cttccagtcg ctggtgaggg tgaagcgcga gagccggttg acaccctgcc aggcggacca
     9361 gtcggtgccg gtgctcggcg catccccgcc cggggtgctc agcggcgggg cgtagtacag
     9421 gtagatgtgc cggttggtcg agaagtacgg gtcgacgccg acgccctgca gcccttcctc
     9481 gtcgtggctg tagaccgcca gggtgccgac gacggcggtg ttgccgttgc tgtcggtgcg
     9541 cctcagggtg ccgttgcgcg cggtgtgcag gaccgagcga tccggcagca ccgccagcgt
     9601 cagcggctcg ccgacctccg gctctccctt ggcgagggtg atctgcgcaa agtcggtggc
     9661 gtcgatgggg tgggcctgca ccgcggtggc cgagcctacg acggtcaccg ctgctacgag
     9721 cagggaactc gctgcagcgg cgcaccagcg gaaccgggac gaacgacctc ggagggattg
     9781 catgggacaa cctcttcctg agcgggacaa aacgctaagc gaggcgcgcg ccgtcgcgcc
     9841 cgatggccta gccggagtga agagaccgcc aagggaaacc gcgccgccgg tccacttcga
     9901 cgtaacaccg aaggtgttgt gtcagaaaca ttaaggagtc gattgaccac tgtctatact
     9961 tttgcagagc caatatggac tttcgctttt cctggcgaaa ctactgccgg tgcgggcggt
    10021 tcgtcgcctc ctcggccaag gccgtcaagg cagcggccac ctgcgccggc acgggcgcgg
    10081 cgccgatctg caacgggcgg gtcaccgtgt accgcgccgt cttcatgcgg atcacggtca
    10141 gggcgctggc cgccgagccg tcgccgacgc tggacaccag gtcgagatac tgaccggcga
    10201 tgatctcggt gcgcataccg gcgaagacgg cgtagccgcg gtacacctgc tcgcgagtca
    10261 gcccacaccc ctggaacatc tcgtccgccc aggccgcaca caggtcgccg cagagcaggg
    10321 cggtgttgcg cccgtaccgc gccgcgtcgc cgcgccacga ggagcgggtg tgcggatcgg
    10381 cgaagagctg gtgcaccgac ggctccccgc gccgccgctc actgccgtcc atgatgtcgt
    10441 cgtggatgag cgcgaacgcg tggaagagct ccagcgccgc ggccgcggtg acgatcgggg
    10501 cgcattcctc gccgccggca ctgcgccggc cccagtagca gaacatcggg cgcagccgct
    10561 tgcgcctgcg agcacgaaac ggtgcagcgc ggtcaagagc ccgcgggggg cgccgtccgg
    10621 ccacccgggt ccctgtcgat gcaggaacgc ggccagctcg gcgtcgaagc gggcccgcag
    10681 cttcgcgttg tcgcatccgc gcgtgaccag ctgagtcatg gcctgccccg caccggcgag
    10741 acacggccgc gccacagtgc gggcggcggg tcggggacgc tcggcatcac tccccctcca
    10801 gaccggccaa ctccagcagc acgcccttga cgtcggtggc ggcgagccgg gtgcgagcgg
    10861 cggacgcgtc cgaacacagc aggaccgggg cgtcggccgg gtcgcccggc agccgcccgt
    10921 gcgagccgcg caccgcctgt gcgcccgcat ccagccccac cacgttcatc agataccgca
    10981 tcccgagctt cctgcgcgcc agcgccagca ccgcgcgccg cttcgccgcg cccggggcgg
    11041 ccggatcgaa gaacagttcg gcggggtcgt atccgggctt gcggtgaatc tccaccaggc
    11101 gcgcgaagtc gggcgcccgg gcggtgtcga gccagtagta ataggtgaac caggcgtccg
    11161 gctcggccac cagcaccagc tccccggctc gcgcgtgatc cagcccctgc cggcgcttgc
    11221 cctcggcatt cagcacgtcg gccaccccgg gcaggccggt gagcagttcg gtcacgtacg
    11281 gcaggtcggc cggctgccgg acgtagacgt gcgccacctg gtggtcggcc accgcgaacg
    11341 cccgcgaggt ccacggatcc aggtactcca tgccgtcctg acggtgcacc cgcaacaggc
    11401 ctccggcccg cagcgcacgg ttgacgtgca ccgggcgttg cacgggcgtg atgccgtact
    11461 ccgacagcgc caccaccgtc gctccgcgcg cgactgccgc ccgcagcagc ggcccgagca
    11521 cggcgtccag tgcggcggcg gccgccgcgg cccgcggatc cgccgggccg tagcgttgca
    11581 ggtcgtagtc cagatgcggg acgtagacca gcgtcaggtc cgggtcgtgc gccgccatca
    11641 cctgctcggc ggcccggcag atccagtgcg aggacgccag gcccgcgccc ggcccccagt
    11701 agctgaacag cgggaaggcg ccgagcctcg cggtcagctc gtcgtgcagc tcgggtggat
    11761 cggtgtaaca gtccgggtcc ttgcggccat ccgcccgata gatcggacgt ggcgtgacgg
    11821 tccagtccac gtcggcaccc atcgcgtacc accagcagat gttcgccacg gtgaacccgg
    11881 gccggcgccg gcgtgcggtg tgccacagct tctccccgcc gaccagggcg ttgtgctggc
    11941 gccacagcag aacctccccg agatcccgga agtaccatcc gttgccgacg accccgtgcc
    12001 cggccggccg ctcgccggtc aggaacgtgg cctgcaccga gcaggtgacc gccggcaaca
    12061 cgggatcgag ccgggccgag aatcctccgt cggcgaccgc ccgcaggcgg ggcatgtgtg
    12121 ccagcagccg cggcgtgagc cccaccacgt cgaggacgac aagcttgctc atcggttcgc
    12181 ctccaccggg ccggccggcc tcaggccgag gtcaccgagc aggtcacggg tgtacgccag
    12241 ctcaccggcg atgccgtcgg ccagctcggc ggcggtaccg ggtcgccggt cgggcggcag
    12301 cacgtcccac gtgtaggtct cgacatcgag gtggtcgcac cagggctcgg cagcggtcat
    12361 gagctcccgc agcccggcct ccagcaccgg ggtggtgctc gccagcggca cggccggcgc
    12421 cgcatgcagc ggaacgtgga aatgcacccg ccacggtccg ggcagatcct cggcaagggc
    12481 gaggtccagg tcgtccgtgc ccgcgccccc ggccgagcgg gtctggtgca ggaaccgggg
    12541 ctccgcatag ggcccgatca cctgccgggc cgccaccggg tcggtgactt ccagagccgc
    12601 actgacctgt accttcacca cgggcaggcc ggccgccgcc aagcggtcga gggccgcggc
    12661 cggctcctcc caggcgcacg ccaggtgggc caggtcgagg cagacaccca gccggtcgcg
    12721 gtcgaccgcc gagaacagcc gcgccgcctg cgcggtggtc tccaccacac agccgggctc
    12781 gggttcgaag ccgacccgca cctcacggcc gctgtcccgg ccgatctcgg cgaggccacc
    12841 ggccaaccgg tccagcatcg ccagcgccgc ctcgtgctgg tccgggcgcc acggctttcg
    12901 ccacgccagc ggcagggtgg agatggatcc gcgacgtacg tcgccgggca gcaggtcgac
    12961 cagcacccgg gcgaggtcga gggtgtagtc caggcgctcg gcggtcgtcc agtccggatg
    13021 gtagacggcg tgcttcacca ccggggcatg gaacgctcgg tagggaaagc cgttcagggt
    13081 caccacctcc agcccgcggg cgtcgagttc ggctcgcagg cgccgccgcg acccggcgtc
    13141 gcgggcgaga gcggcggcaa ccggagccgc cagccacagg cccaggccca gcacgccgac
    13201 gtcgaggcgt tggcgcaccg gtaccgcgta cgcgtccagc tgccgcacga tgccgggcag
    13261 atcctcggcc ggatgcacgt tggtgcagta actcacatgc accgtcccgc cgctgacgtg
    13321 tcgcagtctc atcagctgcc accccgcagg atcgagctgc cctggaagct tgccgggccg
    13381 ggcgccgtcg cggtcaggtg cggccgtccg gactgcccgt agaactccac cggattacgc
    13441 cacaggacct ggtcgacgtc gtcgtcggtg aacccggcgg cgagcatggc ctcaccggtg
    13501 cggcgggtca gcagcgggtc ggagcgaccc cagtcggcgg cggagttgac cagcatccgg
    13561 tgcaggccgt ggccgcgcag gatctccacc atgcgcgacg gcgacatctt cgtgtcgggg
    13621 tagatggaga agcccatcca gcaaccggag tcgtgcaccg cgccgaccgt cacctcgttg
    13681 aggtggtcga cgacgaccag gccgggctcg atgccggatt cccgcaccac gtcgagggtg
    13741 cggctcaccc cccgcgcctt gtcccggtgg ggggtgtgca ccagcgcggg cagggcgtac
    13801 tcgacggcca gccgcagctg aacggcgaag acctcgtcct cctccggcgt catcgcgtcg
    13861 tagccgatct caccgaccgc caccaccgaa tccttgtcca ggtagcgggg caccagcgaa
    13921 agcgcctccc ggcagtgtgg gtcgttggcc tccttggggt tgagggcgat ggtggcgtgg
    13981 tgccggatcc cgaactgagc cgcccggaac ggttcccagc ccaccagcga atcgaagtag
    14041 tcggcgaacg agccggcgtt ggtgcgtggc tggcccaccc agaacgcggg ctccaccacg
    14101 gcctgaactc cggccgcggc catccgctcg tagtcgtcgg tggtgcgtga ggtcatgtgg
    14161 atatgcgggt cgaagatgcg catcgaacct ccagaaccgg tcgggtgaac tggcgcacca
    14221 gcgcgagggc gtcagcaggg aggtggcgtc cggcggcttc gcgctcctcg cgcaggccgg
    14281 ccatcatcgc caccagttcg cggtcggccc gccgcgtcag gtcgtgcacc cgcgacagcg
    14341 gaacgcccag gaagacgcac ttcaggaccg cttgccgcca ggcgcgctgg tccaggtgcc
    14401 gggcgtacgg gccgagggcg gcgctgagca ggcgggtgtc gttcgtgcgg atggcgtcgt
    14461 gcagcaacgg cacggcctcg gcaccgatcg gcaccagcgc cagggcccgc agaacggcgt
    14521 gcttctcgac cgcgtcgccg tagcggtaca gctcgtcgag gtatcgcggc aggtcggtgc
    14581 gcggcagggc gagcagcagc agggcacggg ccgcctcgtc ggcggtccag tccgacgcct
    14641 ccggcaaccg ggagcggccg caccggcggc cggcggccgg gaacaaccgg gtgatgctcg
    14701 gcgggtcggc gctgactcgc gccacccccg cggcgagcca ggcgccgccg caacagtcgt
    14761 gcagtgccgt acgcagtgtg tcggggtcca tgacgtctcc ctctgtcggg catcaggcgt
    14821 gtgccggccg ggcagccggg tgccggtcac cccctccggg ctgcggcctt gaggaactgg
    14881 atggatcggg cggccaccgc gggggcggcg tgggaatgcc ggggcagctc gaccgcgacc
    14941 agaccccggt agcctgccgc gtgcagcgcg gccagcaccg gcgggaaatc gatctcgccg
    15001 gtgccgaagg gcaggtgttc gtgcacgccg cggcgcatgt cgtcgatctg cacgttgacc
    15061 aggtggtcgg ccaccgcggc gacacagtcc ggcaccggct ccggttcccg gcaccggcag
    15121 tggccgatgt cgagcgtgat cccgaagcgg gcgggcgatc cgagcgcgtc gtggagtcgc
    15181 cgccagccgg cgatgtcctc gaccagcatc ccgggttcgg gctcgaagcc gagcaccacc
    15241 gcgtgctcct cggcggcggc cacgacgtcg gcgcagccgc cgaccagccg ttgccaagcc
    15301 gtgcgctcgt ccacgccggg cggccgcacc ccggcccaga acgacaccgc ctcggcgccg
    15361 aggtcggcgc ccacggccac cgcccggcgc aggaagtcga tccgcagctc ccgctcgtcg
    15421 tgcaacaagg tgggtgcgtg cttctcccag gggtcgagaa ggtaccgggc accggtttcg
    15481 atgaccagcg acaacccgag gcgggccaga tcggcggcga ccgcgtcgac ccggcgggcc
    15541 agtccgggcg cgaagggatc gaggtgaccg tggtccaggg tgagcgccac gccgtggtag
    15601 ccgaggtcgg cgagaatggt cagggtgtcg gtgagccgat ggttggcgaa gccgttggtg
    15661 ccgtacccga agcgcagacc ggtcacgtcg ggctcaccgc cctggccagc cgcgcggcga
    15721 gctccgcgac gcaggcggtg gccgcaccgg cagccaccgc accctggcgc gccgtcaatg
    15781 caccctgcaa gaccggcaag gtggtgatgc cggccccgac cgcggcccgg acgcgcgccg
    15841 cgctggggtc accgatcacg gcggcttgga ccgccccgta gcgggccgcg taccagccgg
    15901 ccagcgcggc cggtacgagc gtgcgccgca gccgggtgcc gggcccgggc cgggtggacc
    15961 cggccagccc ggcaaccgcg gccgtcgcgg cgagcgtacg caccggcagt gatgctttcg
    16021 cgccgtggac ctcggcacgc gagagcatcg tgaccgtgtg gtgtgcgcgg caaccgtcaa
    16081 cgtggtggcc aggaccgcgc gtggccgggc ccgccactgg ccgtccgcgc cgagcagcac
    16141 gtcgaggcct cggcaggcgg ccatcacggc cggtccggcc atcgtgttct tcgctcccag
    16201 gtcgtacgcc cagatggcgc cggccagagc gagcgccacc ggaagccgcc ggcgcccgcc
    16261 ggccagtccg gccaccgcca tcccggcggc ggtcaggccg accgccagtc ccaccgctgt
    16321 ggtcgcgggc acccgaccgg acgggatcgg ccggtcgggg cgctcgaccg cgtcgaggtg
    16381 gcggtcggcc cagtcgttgg ccgccattcc cgcccagtaa aggcagaccg aggcgccggc
    16441 cagtgccagg gtgcgtggcc gcagggtgcc cgccgcggcg gcaccggcga ccgcgtcacc
    16501 gggcacggag agggcggccg gggcgcgggt gagttcgatg agatcccgcc agccggtcat
    16561 gccggcgact ccgccccgag cccggcggcg aacgcggtca gcgcctgcca ctgctcggcg
    16621 aaaccatgcg ccacgtcgcc gagcggatcc ttgaagaaga aggcaagttc gtgcagcggg
    16681 ccgacacgcc cggcggcgtg cgccgcgccg gtgagccggg ccaggtccag caccaagggc
    16741 gcggccagcg ccgagtcaca gccgtgccag gtgaattcca ggcgcatgcc ggtgcccagg
    16801 aagccggaga aggtgaccag gtcccaggcc gtcttgaagt caccgatgtc ctcgacgtac
    16861 tcgattcgca ccgcaccctg cggctgatag ccgagcgtct ccttgaggac gcgctgcttg
    16921 ctggcgctct tggccgcgtt ggcgcccggg tcggccaggg tggccccgtc gcctccgccg
    16981 agcaggttga cgccggacca actgcgcacg tgcaggtgac ggcgggcgaa catcggcgcg
    17041 agcaccgact tcagcagcgt ctcgccggtc ttgccgtcgt tcccggcgta gggcagcccg
    17101 cgtcgccggg cgatttcggc cagtgcgggc aggcgcgccc cggtcgaggg ggtgaagtcg
    17161 acatacgagc atccggcgga gaaggcggca taggcgtaga gcgcgctcgg tggaagcacc
    17221 gcctcgccgc ggcgcaacgc cacgttcagg tccgctgccg tggcatgggc cggatgagcg
    17281 gccgcaaggg gctcggtgga ggagacgttg accacgacca cccggtccag gccgtaccga
    17341 tcccggaagt cgcgcaggtc cgcctgcagc gtggcggcgg tctccgcctg gctctcgccc
    17401 gccggggcca gccggatgtc ggcgtcggcc cggacgaggt cgtcgtgcac cgcgcgcacc
    17461 agggcggcgg gcagcacacc tgaggcggcc agctccccgg cacgcttggt caacggcgtg
    17521 gacacccggt catggccccc gaagaccaga tcgccgaagc cggcgaggcc ggcggcccgg
    17581 aattcaggga gttcggtgac gcacccggta ccgggcacca ggccggcacg cagggctgaa
    17641 gctccgacaa tgctggtcac cgcgacgcta ccgcgcccgc cgaccaacca gacacccaca
    17701 gtcatggatc ctccgaaagc gcagctgcgg cgatggtgga gaggggcccc gcccgcacgc
    17761 cgcccggtca cctgtcgcgg cacggaagtc ggcggtatca gcaccgccac gagtgcggcg
    17821 gcgtacgggc agggctggca ggccgagccg ggtggcggcc cggccggccc gccgtcgaca
    17881 ccgagcccgg ccgtctcggc tgggccggtc ggtgatggtg gagaacaggg ttggccggca
    17941 acggcgtacc gagccgtccc ggtggtcgcc cggtgcggac cgggaatccc gtccgagccg
    18001 catcgcgggt gaaccacccg gccgccgacc gtccggacgg ccggggcgca accgggtccg
    18061 gaccctcgtg gaacgacggc cgagaaggat gaagggaatc gctgattgtc gtcgccgccg
    18121 gcacgaacgc ggcggcttgc cggccgcgag gggccggtca ggcgatggcc tcggtcgggg
    18181 ccgacttcac ctccaaccat gtcgagccca gctgcgcgga gcgtacgacg gcatcgagga
    18241 cgagctgcac ctgcagggcg tcggcgaacg aaggcgccac gtccgccccg gtggcgatcg
    18301 cctcgatcag gtcgcgtgcc tggtgggtga aggagtgctc gtagccgatg aggtggccgg
    18361 gaggccacca tccggacatg tacggatggg tgggttcggt gacgaggatg cgggtgaagc
    18421 cctgctccgc ggcggggagg gtggcgtcgt agaactcgag ctcgttcatg cgctcgaagt
    18481 cgaagacgag ggacccccgc gaaccgttga tctccactcg cagcccgttc ttacggccgg
    18541 tggcgaatcg ggtcgcctcg taggtggcga tcgccccgcc gtccagccgg gccaggaaca
    18601 gcgcggcgtc atcgacggtg acctcgcccc ggcctgccgg tccgcccccg gagccatcgc
    18661 tcgccgcggc gctcaggccg ctcgacgctc ccggcagcgg ccggtgcttg acgaacgtct
    18721 cggtcagcgc gctgactccg gcgatgcgct gaccgacgac gtactgggtg aggtcgatga
    18781 tgtgcgcacc gatgtcaccc agggcgccgg agcccgcctt gtccttctgc agccgccaga
    18841 ccagcgggaa ctccggatcg gtgatccagt cctggaggta caccgcgcga acgtgccgga
    18901 tctcgccgag ccgcccctcg gcgatcatgc ggcgcatcag gctgacggcg ggcacccgtc
    18961 ggtagttgaa gccacacatc gaccgcacgc cgagcgcggc ggcccgggcc gccgcggcgg
    19021 ccatggcctg ggcctcgtcg agcgtgttgg ccaacggttt ctcgcacagt acgtgcttgc
    19081 cagcgtccag ggctgcgatc gcgatctcgg cgtggctgtc accgggcgtg cagatgtcga
    19141 tgaggtcgac gtcgtcacgg gcgacgagcg ctcgccagtc actcgtgtgc tcctgccagc
    19201 cgagctgggc cgccgcctcg gcgaccttcg cctcgccccg gccgcagacg acagccatcc
    19261 gggcctgcat cggcaggtcg aagacacggt tcacggtgcg ccacgcctgt gagtgcgcgg
    19321 ttcccatgaa cgcgtagccg atcatgccga cccgcagatc cgtggtgtgc gtggacaaga
    19381 tgggtctccc cccgtgcgat cagaacccga acttgaggta cttgctcgcg ttctctttgg
    19441 tgatggtttc ggaggcgagg acaagttcct tcggcacctg aagctccacg aggtccgcca
    19501 tgcccttgtt ctggccgatc agtcgggcca gcgagatggc cgaggacgcc atcgacgggc
    19561 tgtaggtgac cgtcgccttg agcggcgtgt tgtcggtctg gatgtccccc atggccttct
    19621 tcgagcccgc gccgccgacc atgatgaact ccttgcggcc ggcctggttg gccgccgcaa
    19681 gcacgccgat accctggtcg tcgtcgtgat tccagagcgc gtccagcttg ggcagtgctt
    19741 gcagcagctg gctcgccgcc cgctgcccgg tgtcggccgt gaactccgcg ggcacccggc
    19801 gctgcacctt gaaacccgcc gcgttcaggg tgtccgcgaa gcccttcgac cgctcctggg
    19861 tcagctccag cgagtcgatg ccggggatct cgccgatgac cgggctgctg acgcccctgg
    19921 ccttcatctg ggcgatgatg taggccgccg cggccacgcc catgccgtag ttgtcgccct
    19981 tgatctgggt gcggtaggca cgggcatcgg ggaacgcccg gtcgaggttg accacgggta
    20041 tgccggccgc catcgcttcg aggccgaaag cgttgagctc cttgccgtcg tgcggcagca
    20101 ggacgatcac ctggggcttc tgcgcgatca gcgtggacag ggccgcacgc tgggccgcgg
    20161 cgtcagctcc ggcctcgacg gacttgaatt ccacatcggt gtacgttgcg gcctgcgcct
    20221 tggcgttgtt ggtgatcgcc gcgatccagc cgtggtcggc cgccggagcg gagaagccga
    20281 tgaccacctt ctcgcccggt gcggcgttac cgccggccgc gacgtccttg gtctgcgcct
    20341 gagtgggctg ggcttcgttg ctggtgcatg cggtgaggaa cgtaccggcg cccagagccg
    20401 cgccgccgag caacagtcgg cgccgcgaca ggtcgcgact gtgctgtgac atgacttctc
    20461 ctgaatcaaa tcggtgtgcg aaaaggacag atgcggggtg tgcgggaccc ggcgaccgtc
    20521 cggccggacg gtcaccagga agttcg
//
