LOCUS       NZ_CP023865            22184 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4321754
            Orig. end                         :: 4343938
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22184
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="15"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..22184
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22184
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12184](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12184
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     misc_feature    423..436
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    910..924
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    complement(1114..1123)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    1216..1234
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     misc_feature    1233..1247
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.06"
                     /tool="antismash"
     misc_feature    complement(1241..1256)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    complement(1241..1256)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            complement(1253..1885)
                     /locus_tag="ACTEI_RS19115"
     CDS             complement(1253..1885)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="ACTEI_RS19115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_164466019.1"
                     /transl_table=11
                     /translation="MGRSRTKPAPSAPVTARGRRTRDALVAAGRELLETRGWPGFTPEQ
                     VAQAAGVSYGTFYTYFESKDDLLRTVVRMVAEEMFAESRVAPDTAGDPYARIVAANRGY
                     LRAWRNASRVLRLVERGADSDDTLRRLLLEVRELYVHRGAEGLRRLQEAGLADPGLDPR
                     MTAIVLGAMVEQMAHVIYALREPLEEEAVVEHMSKLWAAAIGLRAQA"
     gene            complement(2199..2927)
                     /locus_tag="ACTEI_RS19120"
     CDS             complement(2199..2927)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013474164.1"
                     /locus_tag="ACTEI_RS19120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2071 domain-containing protein"
                     /protein_id="WP_122978904.1"
                     /transl_table=11
                     /translation="MDVEEITTETVRPVARVVLGQRWTDLAFLHWPVDPARVAPLLPAG
                     TVPDVLDGVTYAGVIGFRMERFGFLRGPGVPYLGTFCETNVRLYSVDGRGRRAVVFRSL
                     EAERLIPVLVARVSLRLPYMWARMRLTRDGDQLAYVSRRRWPGPRPAVNRMRIRVGEPI
                     AEPSRLEHFLTARWGLHTRAWGRTRHLANEHPRWPLHRAELLDLDDTLLAAAGLPGIDT
                     PPVSVLYSPGVPVTFGPVAT"
     gene            3179..3697
                     /locus_tag="ACTEI_RS19125"
     CDS             3179..3697
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012791.4"
                     /locus_tag="ACTEI_RS19125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="universal stress protein"
                     /protein_id="WP_164466020.1"
                     /transl_table=11
                     /translation="MRTELSGSRLDCLAAAVSLRLPPGGRRALRADPCHGAVDVLGTPD
                     PPGAVVLAAITDDHARHAVLEHAAGRARELGLPLRAVHVWDGHRPYPDLLLDATCYADL
                     DAGTAAAVRREIRRDRHPAHALSALSHHAALLVVAATGALGTARTLGATAAALIGHTAC
                     PLTIVLPTR"
     misc_feature    3762..3777
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.75"
                     /tool="antismash"
     gene            3763..4599
                     /locus_tag="ACTEI_RS19130"
     CDS             3763..4599
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621515.1"
                     /locus_tag="ACTEI_RS19130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="universal stress protein"
                     /protein_id="WP_122978906.1"
                     /transl_table=11
                     /translation="MKIIIGYDGSSDARAAADWALDEAQRTGLPVEFVYADEWPFWLMP
                     SPVLATDQSIKHAIATMLRRAVAEAERSHPAVQADWVRIRAHAAPALIERSADAALLVV
                     GGRGHSAVAGLLGSVAAAVGAHAHCPVVIARGDPDPAAPVVAGVDDSPAAAAVLRFAAE
                     HALARGVPLRVIRAWPPVTGLFEDASWAARTVPASLREPFDALVTEIRDAYPGLQVRAE
                     AVPDDPGGALERAAAGAQLLVAGSRGLGPVRGLLAGSVSQRLLRHSPCPVAVLHTT"
     misc_feature    complement(3764..3777)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.05"
                     /tool="antismash"
     misc_feature    3764..3778
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            complement(4651..5634)
                     /locus_tag="ACTEI_RS19135"
     CDS             complement(4651..5634)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014690118.1"
                     /locus_tag="ACTEI_RS19135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_122978907.1"
                     /sec_met_domain="APH (E-value: 5.7e-16, bitscore: 57.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSITKNRQRPDVLQAMIERAYGPGEVPAGGDWCSELGHGWFNVA
                     YRIRLRSGREVVLKIAPPPAVEVMTYERGAMATELTALRLIREHTTAPVPAVEYADRGH
                     RLCDADWFVMPYIDADNLGMLRDRHTPAQRAAYDEALGALNRELNTIRGAAFGPLAGPG
                     FPTWRAAFTRMIEDVLGDGERRDVDLGHDYRMVREVIAAHAGALDEVTEPRFVEWDMWD
                     NNVMVRDGRIVAIIDHERALFGDPLIEAGFTGSEVPAYGDSSAFIRGYGHGPSTPDERV
                     RRRLYCLYLALIMTIETAYRNFPGTDNYDWARKRLDETMALFDRAG"
     misc_feature    complement(5666..5680)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.76"
                     /tool="antismash"
     misc_feature    5667..5681
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.67"
                     /tool="antismash"
     gene            complement(5835..6839)
                     /locus_tag="ACTEI_RS19140"
     CDS             complement(5835..6839)
                     /EC_number="1.1.1.28"
                     /GO_function="GO:0008720 - D-lactate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070404 - NADH binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018734797.1"
                     /locus_tag="ACTEI_RS19140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-hydroxyacid dehydrogenase"
                     /protein_id="WP_122982255.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.2e-56, bitscore:
                     188.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVAVFSTKPYDSRFLSEANHEAGHELTFLEPRLTPDTASLAVGC
                     DAVCAFVNDDLGAPVLERLATAGVRMVALRSAGYNHVDLGAARRLGLAVTRVPGYSPYA
                     VAEHCAGLVLALNRRIHRAYNRVREHNFALNGLLGFDLHGRTVGVVGTGKIGVCFIRIM
                     AGFGCRVLATDPYPAREAIEAGATYVPLETLLAESDVVTLHCPLTPETHHLIDESRIAM
                     MREGVMLINTSRGALVDTAAVIRGLMSGRIGHLGLDVYEEEAALFFEDLSDQVLSDDLF
                     TRLVSFPNVLITGHQAFFTEDALRNIAASTIGSLTAYGRDGSTAGIAPDALVH"
     gene            complement(6902..9178)
                     /gene="katG"
                     /locus_tag="ACTEI_RS19145"
     CDS             complement(6902..9178)
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540302.1"
                     /locus_tag="ACTEI_RS19145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_122978908.1"
                     /transl_table=11
                     /translation="MSDIQDNAPASAQGVDKKAAAGCPVAHDSVTSQGSESENPGISSP
                     TPKTGGRPRSNRDWWPNQLDLSVLHAHSSKGNPLGPDFAYAKEFAKLDVEALKRDIIET
                     LTTSQDWWPADFGHYGGLMIRMSWHAAGTYRIHDGRGGAGDGGQRFAPLNSWPDNANLD
                     KARRLLWPVKQKYGQKISWADLLVLAGNVALESMGFKTFGFGFGRVDVWEPEEIFWGPE
                     DTWLGDERYVSDKEMAADVGATEMGLIYVNPEGPRGNADPLAAAHFIRETFARMAMNDE
                     ETVALIAGGHTFGKTHGAAVANDHVGPEPEAAPLEAQGLGWLSTHGAGKGGDTITSGLE
                     VTWTDKPTEWSNRFFEILFGYEWELTTSPGGAKQWVAKDAEAIIPDAHDPSKKHKPTML
                     TTDLSLRVDPVYEKISRRFLENPDEFALAFAKAWYKLLHRDMGPVSRFLGPWVPEQQLW
                     QDPVPAVDHPLVTDTDVAALKAKVLESGLSTAQLISTAWASAASFRSTDKRGGANGARI
                     RLEPQRNWEVNQPEQLATVLATLEGIQQEFNAAGGAKISLADLIVLAGSAAVEKAARDA
                     GVEVTVPFHPGRTDASQEQTDVESFRVLEPRADGFRNYLRPGEKTQPEVLLVDRAYMLN
                     LTAPEMTVLLGGLRSLGANFGGSQHGVLTDKPGALTNDFFVNLLSPGTRWKASESEEHV
                     YEIRDLATDQVKWTATAVDLIFGSNSQLRALAEVYASDDAREKFVTDFVAAWVKVMELD
                     RFDLV"
     gene            complement(9202..9630)
                     /locus_tag="ACTEI_RS19150"
     CDS             complement(9202..9630)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286851.1"
                     /locus_tag="ACTEI_RS19150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_122982256.1"
                     /transl_table=11
                     /translation="MTAGFEAQLRAVSLRVTRPRLAVLTALRDHPHIDTDTVIALVRED
                     LPSVSHQAVYDVLRALTDTGLVRRIQPAGATARYEMRVRDNHHHVVCRSCGAIADVDCA
                     VGHAPCLTASDDYGFLVDEAEVVFWGTCPDCVTNRTPE"
     misc_feature    complement(9648..9662)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.83"
                     /tool="antismash"
     gene            9847..10017
                     /locus_tag="ACTEI_RS38445"
     CDS             9847..10017
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS38445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164466021.1"
                     /transl_table=11
                     /translation="MDLIEDQRRDLAPLEDLRRTPLGGIDPRRAAEVARAQTRDEAERG
                     RIDSALFGSAI"
     gene            10001..12184
                     /locus_tag="ACTEI_RS19155"
     CDS             10001..12184
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020216176.1"
                     /locus_tag="ACTEI_RS19155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_239082417.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.3e-64, bitscore:
                     216.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 7.9e-158,
                     bitscore: 523.8, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.3e-12, bitscore: 47.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPPSSPISQYVLKIASRCDLKCDYCYVYEHADQGWRRQPPQMEP
                     ATVTAVARRIAEHAERHRLPTVRVVLHGGEPLLVGARRLDEIAAELHAIVGPRLDLRMQ
                     TNGVLLTEEICHIAKRRRIRIGVSLDGDLAAHDRHRRFAHGGGSHRHVLRALSLLRAEP
                     NRAAYAGLLCTVDLRNDPLRVYHALLAQQPPRIDFLLPHATWDNPPPGAGATPYARWLS
                     AVFRRWTADGRPVPIRLFDALLSPGTVGAEAVGLGPADLVVIETDGSYEQVDSLKVAYD
                     GAAATGLDVFTSPVDEVAAHPMIAVRQTGLAGLSATCRACDVVDRCGGGQFAHRFRTGT
                     GFDNPSVYCADLKELIDGMDDRDALATWVRDELAGGAGGADALAQLAPVHEAMVRARLV
                     TLAAHGPAGTPPPGWAQLVALDETAPEAVRAVLTHPFVRRGDAAHLAGVAAAAAIRAGA
                     EIRLAVPVHDGLLALPTLGALRWPDGDPVAEVRTFAGGFHAGDVTVRLDRPSARWLPAR
                     RLRLGDGPPVLLEDTDPLRDAYPGLPLTGRLDDAAAAAWQQRLDGAVAGLRADAPEYLP
                     GLAATLRAIVPLRHDGTGTQRAGSARTAFGAVAATPEDPDALALLLVHEVQHLKLGAVL
                     DVCPMFDARDPRRLPVPWRPDPRPAEGVLQGTYAFLAVADVWRRRPGPAAAARFTQLRG
                     WLDVVLDRLLGAAFLTPAGVRFATAMRGTVDRW"
     gene            12178..13014
                     /locus_tag="ACTEI_RS19160"
     CDS             12178..13014
                     /codon_start=1
                     /gene_functions="resistance (resist) AAC3"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289094.1"
                     /locus_tag="ACTEI_RS19160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAC(3) family N-acetyltransferase"
                     /protein_id="WP_122978909.1"
                     /transl_table=11
                     /translation="MVNHDLAEDLRRAGLRPGATVLAHCSLHEVGWLPDGPATLRRALQ
                     RVLTPGGTLVVPTHTAGNSNTSDQYRRATAGKSAAARAAWEDAIEPFDPDTSPSHEMGL
                     LAEDVRRHPGTLRSRHPHTSFSALGPRARELTAVHDLDCHLGERSPVGALYAADATVLM
                     IGVGYDHCTAFHLAEYRLPTPPRRRAHRCYVRDERGGRRRVDFLAPHLDDHDFPLLGAA
                     FEGTGVVRAGRVGNARTRLFEIRAAVDFAVGWMTEHRGRSPGCPDSPAVDIVNLHR"
     gene            13041..13694
                     /locus_tag="ACTEI_RS19165"
     CDS             13041..13694
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040588.1"
                     /locus_tag="ACTEI_RS19165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIR-like protein FxsC"
                     /protein_id="WP_122978910.1"
                     /transl_table=11
                     /translation="MTSSSRTPVFFISYAHRPQRARAQRDAHLVREFYDTLYGHVDELL
                     GLQAGQEAGFMDAELDGGQRWSDDLAYAIGHCQVLVPLISPRFGGSEWCAREWHAFARR
                     PHRKFPKAKSSHGATPIIPVSWTPFPIEQLPGEIAAVQFFTPAGLPAPEMARLYHREGL
                     YGLLQLGERGLEVYEAVVWKLAQWIADAFWTHDVEIDDDVDFRGLPTKFGEDPT"
     gene            13691..14716
                     /locus_tag="ACTEI_RS19170"
     CDS             13691..14716
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018806203.1"
                     /locus_tag="ACTEI_RS19170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIR-like protein FxsC"
                     /protein_id="WP_222942285.1"
                     /transl_table=11
                     /translation="MIFYLSHAHAARGGGAPDPWVRRFFDALSDAVHARTGDGGFHDGQ
                     LAPGADSKQQLTAALGQAQVFVPLYSPQYFNNSWAVAELTSFRSRLRGFAPAEAARHIV
                     PVVWTPLPPWAARPEVDEAFGLVGKSVEYSENGMRALCMLSVYRDAYRDLVTRFADRIA
                     AVVHESPLAPSAAAPPVPRPPDTGEPALLVSLLAAEGSGYDLPALAGRVLAAAERLGVP
                     ALQAPPDQVRRQAGRRPCVLLIDAGAGPETVRATVTGLPGWVIALVVASASAATGALTG
                     ILRTAGLPRVSPVRTVAEFERTAPLLVTEARKQYLRHGPVVTAPGSPRPSLRRTVDDKR
                     G"
     gene            14725..18582
                     /gene="fxsT"
                     /locus_tag="ACTEI_RS19175"
     CDS             14725..18582
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019900565.1"
                     /locus_tag="ACTEI_RS19175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_122978911.1"
                     /transl_table=11
                     /translation="MVDREGQIVTFYSYKGGTGRTMALANVAWILAANGHRVLAADWDL
                     ESPGLHRFFAPFLSPEQVATTRGVIGLITEYQWATLPRDERGNGLPETERPADWYREYA
                     KAERYAFSINWAFPGGGSLDVLLAGHSSLEYEASLNGLNWEDFYNRLGGAHFFDALRED
                     MKSRYDYTLLDSRTGLSDVADICTIHLPDVIVDCFTLSEQGIDGGASVAAQIRTYEDER
                     LRRILPVPMRVDNGEQSKADAGRTLARRRFTRLPAGMTEEERRNYWYEVEVPYRTYYAY
                     EEMLATFGDEPGNPASLLSSYERLTGYITDGRVNRMPPLEPGLRRQVVARFERKPALVE
                     ETLMLRYAPQDQVWAEWALAVYTAARLRVVDGGRSGEPADPGTREVVLHSDEFAGTGNR
                     SAVALCVGDSTPAPDEFDAWDSLHGHGAESAIGRALRLVGADDRGAADWHATLPRYPGE
                     LPQVQNPPTRNPRFTGRDSELRRIRETLKRAGGTPVALVGGAGTGKSQLAIEYAHRFAG
                     AYDVIWWVPADPPQFVETIMADLGAELNYPRRATLDDTAGVVVRRLSRGGGREGTPLRW
                     LLIFDNADRHADIARYLPRGNGHLLVTTRNAEWGDVAKVIEVEGFSRAESIEHLRFRVG
                     TQAITRAEADRVAEAVGDLPILVVLAAAWLHDTGRSAQEYLSGLEKSGTVRNAAIGVWE
                     VILERLRATSNGAYRLLQLASVLQPDISLSLLYSDEVARVIAQYDKDVARQLADRMSEH
                     DVTSALMQPINRLSLVKLDPEKRRVTVHRLLQSALRDRMAPERLAEVRHAVHRVLARAR
                     PAGEVEDAQTWDAFRLLWSHLDGSDPEGCRDDDVRQLVIDRIRYIYLVGSFRQGLDYAI
                     RADRRWSAQLETLSPDDEDRHALLVRLLHLRFHRGNLLRSLGEFRQALELDRETLRAQE
                     DLIGDSHPYTLFTAGSYGADLRALGHYQEALQRDILTYRLSADRFGEDNRRTLAFANNL
                     GTSYRLTGDFRRALDMDRTTLQRMTQTLGDDHFRTLLSANNVGRDLREAGEYRESVNLL
                     RGVRRGFEKLYGQHSRDALSVQTNLAVSMRGAGQVDEARELLDEAYERLTVVLGPESPE
                     TLITRLSRAATMLLTEDFATARAEFEQVESILVRRFGEGHPYVLIGRHNLAVALGEAGA
                     VELALPIARATTGALRDKLGERHPATMAAENNLALFLIESGERETGRQLLADTVDRLIC
                     TLDEDHPDTYLSQGNLALTGRTDHLQIAEQLAERLGSDHPTVRSLHRRRRVYRILDPHT
                     Y"
     gene            complement(18602..19519)
                     /locus_tag="ACTEI_RS19180"
     CDS             complement(18602..19519)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (33-284). E-value:
                     3.6e-18. Score: 58.0. Matches aSDomain:
                     nrpspksdomains_ACTEI_RS19180_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289097.1"
                     /locus_tag="ACTEI_RS19180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_239082416.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-13, bitscore: 49.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.2e-13, bitscore:
                     48.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVADAASGTRLVRRPRDGRRIAFEVLGPAHGFPVVLLHGTPGSR
                     LGPRPRGIVLHRLGIRLITYDRPGYGDSDRVRGRDVAHAAQDVRAIADALRLDRFSVVG
                     RSGGGPHALACAADAALRDRIIRVAVLVSLAPAGAPGWFDGMNDDNHEQMSKAVTDPAE
                     LESEIRRRATEISTDPDFLLGLLTEQMTVADQRVVSDAALRRQLRLSYRDAIKNGPYGW
                     IDDLFALRRDWQVDLRAITAPVRLWHGGEDTFAPAVHSRYLAHQIGTAELDVRPGAAHF
                     DAMPELPRTLRWLAARPVVAGLAR"
     aSDomain        complement(18668..19420)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTEI_RS19180_Abhydrolase_1.1"
                     /evalue="3.60E-18"
                     /label="ACTEI_RS19180_Abhydrolase_1.1"
                     /locus_tag="ACTEI_RS19180"
                     /protein_end="284"
                     /protein_start="33"
                     /score="58.0"
                     /tool="antismash"
                     /translation="PVVLLHGTPGSRLGPRPRGIVLHRLGIRLITYDRPGYGDSDRVRG
                     RDVAHAAQDVRAIADALRLDRFSVVGRSGGGPHALACAADAALRDRIIRVAVLVSLAPA
                     GAPGWFDGMNDDNHEQMSKAVTDPAELESEIRRRATEISTDPDFLLGLLTEQMTVADQR
                     VVSDAALRRQLRLSYRDAIKNGPYGWIDDLFALRRDWQVDLRAITAPVRLWHGGEDTFA
                     PAVHSRYLAHQIGTAELDVRPGAAHFDAM"
     misc_feature    complement(19530..19545)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    19532..19543
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    complement(19831..19847)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    complement(20273..20286)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(20426..20439)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    20516..20527
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.1"
                     /tool="antismash"
     misc_feature    complement(21174..21189)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    21281..21294
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(21291..21306)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
ORIGIN
        1 ggtgggcggt ctccaggacg ccgaactctc gggcggcggc cggcggcgcg gtgacgtgga
       61 agcccgggta ggaggccagg gccagctcga cggcggcgcc gctgaacgcg cggccgacca
      121 cgtccgggtc gaaatcctgg acgtggcagt gcagcagggc ggacgcctgc gcctgggtgg
      181 ccggatcggg ccggtcggtg cgggccagct cccaggtgat cacggccggc ggccgggcca
      241 gggcggcctc cagctggcgg cggacccacg ccgccttcgc ctcgatgtcc aggccggtca
      301 gcacgaacgt gacggtgttc cggtgcccgc cggggcggtt gacggcgacc ttggcggtgg
      361 ccggcggcgc cgcaccccgt accccgaaga tcttgacccg gtcggcgccc tgctgcacca
      421 gctggaccgt gtccagccgg gtgaccacgt cggggccgag gtagcgaggc gtgtcgatct
      481 cgtagacgag ctgcgcggtg accgtgtcca cggtgaccgc gccgccggtg ccgggatgct
      541 tggtgatcac cacggtgccg tcggcggcga tctcggcgag cgggaagccg agcgggcggc
      601 cggtgtccag ggtggtgaac ccgctgaagt tgccgccggt ggcctgcgtg ccgcactcca
      661 ggacgtgccc ggcgacggtt ccggcggcga gcaggtccag gtcctcgcgg gtccagccga
      721 actcggcgac cgccggtccg agggtcagcg cggcgtcggt gacccggccg gtgaccacca
      781 cgtcggcgcc gtggcgcagg gcttcggcga tgccgaacgc gcccaggtac gcgtgggcgc
      841 ccagcgctcc gggccagtgc agcgcgtcgc cctccacgtg cgcgacccgc acgccgccac
      901 cgagctcccg gatcgcctcg gccagcccgg ccgggttgac gccgccggcg ttggccacga
      961 tccgcacgtt cgccgagcgg gccaggccca ggcactcggt gagctggcgc aggaacgtcc
     1021 gggcgtagcc gagccgcggg tcccgccggc ggtcgcggcc gaggatgagc atggtcagtt
     1081 cggccaggta gtcgccggtc aggtagtcca gcgggccgcc ttcgagcatc tcgcgcatgg
     1141 ccgacaagcg gtcgccgtag aagccggagc agttgccgac gcggatcgat cgcaccaagc
     1201 ccggctcccc tcgcttgtgg tgagggtcac gttaggcaat ctgacaaaat tgtcaagcct
     1261 gcgcgcgcag accgatcgcg gccgcccaca gcttcgacat gtgctcgacc accgcctcct
     1321 cctccaacgg ctcccgcagc gcgtagatga cgtgcgccat ctgctcgacc atcgcgccga
     1381 gcacgatcgc ggtcatccgc gggtccagcc ccgggtcggc cagcccggcc tcctgcaggc
     1441 ggcgcaggcc ctcggcgccc cggtgcacgt acagctcccg gacctccagc agcagccgcc
     1501 gcagcgtgtc gtcggagtcc gcgccccgct cgaccaggcg cagcacccgg gaggcgttgc
     1561 gccacgcgcg caggtagccg cggttggcgg cgacgatccg ggcgtacggg tcgccggccg
     1621 tgtccggcgc cacccggctc tcggcgaaca tctcctcggc caccatccgc acgaccgtgc
     1681 gcagcaggtc gtccttggac tcgaaatagg tgtagaaggt gccgtaggag accccggccg
     1741 cctgcgccac ctgctccggc gtgaaacccg gccagccgcg cgtctccagc agctcgcggc
     1801 cggccgcgac cagcgcgtcc cgggtccgcc gcccgcgcgc ggtgaccggc gcggacggcg
     1861 ccggcttggt tcgtgatcgg cccatggcca ccatcatcgc gcccgcgacc ggcgccaccg
     1921 ccggccggac cgcagccgac gccggcctgc ggtgcccggc cggaccgcag ccggcgccgg
     1981 tttgcgatac ccgacccgac cgcagccggc gccggtttgc gatacccgac ccgaccgcag
     2041 ccggcgccgg tttgcgatac ccgacccgac cgcagccggc gccggtttgc gatacccgac
     2101 ccgaccgcag ccgggcggaa ccagcgcccc acggccggtc ggaccgtcac cggccgggac
     2161 cagcgcacca cggccgggcc ggaccgcgac cgggcccgtc aggtggcgac cgggccgaag
     2221 gtgaccggca cgcccgggga atacagcacg ctcaccggcg gcgtgtcgat gccgggcagg
     2281 ccggccgccg ccagcagcgt gtcgtcgagg tcgagcagct cggcccggtg cagcggccac
     2341 cgcgggtgct cgttggccag gtgccgggtg cggccccacg cccgggtgtg cagcccccac
     2401 cgggcggtga ggaaatgctc cagccgggac ggctcggcga tcggctcgcc gacccggatc
     2461 cgcatccggt tgaccgccgg gcgcggtccc ggccagcggc ggcgcgagac gtaggcgagc
     2521 tggtcaccgt cgcgggtcag ccgcatccgc gcccacatgt acggcagtcg caggctcacc
     2581 cgggcgacca gcaccgggat cagccgctcg gcctccagcg accggaacac cacggcccgc
     2641 cgcccccgcc cgtccacgct gtacagccgc acgttggtct cgcagaacgt gcccaggtag
     2701 ggcacccccg gcccgcgcag gaagccgaac cgctccatcc ggaagccgat caccccggcg
     2761 taggtcaccc cgtcgagcac gtccggaacg gtgccggccg gcagcagcgg cgcgacccgg
     2821 gccgggtcca ccggccagtg caggaaagcc aggtcggtcc agcgctgccc gagcacgacg
     2881 cgggccaccg gccgcaccgt ctcggtggtg atctcctcga cgtccatcgc accagcctgc
     2941 cgcagcgccg tgggcactcc ggcgcccggg gccccgcgac accgcccgca cccgccgtga
     3001 ccaggccgtt aggcccttaa ccgggcgcct gagcgagcgg gacgatacgg gtgaggcgga
     3061 caccgggtgg ccgggccggc cggacggcgg cgactggccg cggagccgcc ggacgcaccg
     3121 tcgccgctcc cggtgtgcgc cgcctcgtcc ggtcgcggaa aaccgtgagg tgatcactgt
     3181 gcgtacggaa ctctccggaa gccggctcga ctgtctcgcc gccgccgtca gcctgcggct
     3241 gccgcccggc gggcgccggg cgttgcgggc cgacccctgt cacggcgcgg tggacgtcct
     3301 gggtacgccg gatccgcccg gcgccgtggt gctcgcggcg atcaccgacg accacgcccg
     3361 gcacgccgtg ctggagcacg ccgccgggcg cgcccgggaa ctcggcctcc cgctgcgggc
     3421 ggtgcacgtg tgggacggcc accggccgta cccggacctg ctgctggacg ccacctgcta
     3481 cgccgatctg gacgccggca cggcggccgc ggtgcggcgg gagatccggc gggaccggca
     3541 tcccgcgcac gcgctgtccg cgctcagcca ccacgccgcg ctgctggtcg tcgcggccac
     3601 cggggcgctg ggcacggccc gcacgctggg cgcgaccgcg gccgccctga tcgggcacac
     3661 cgcctgcccg ctcaccatcg tcctgcccac ccggtgaggg cccgcggctg acccgcggtc
     3721 ccggcacccg cgcgaaccgg ttacctcgac gaggaggaca ccatgaaaat catcatcggg
     3781 tacgacgggt cgtccgacgc ccgcgcggcc gcggactggg ccctcgacga ggcgcagcgc
     3841 accggcctgc cggtggagtt cgtctacgcc gacgagtggc cgttctggct gatgccgtcc
     3901 ccggtcctgg ccaccgacca gtcgatcaag cacgccatcg ccaccatgct gcgccgcgcc
     3961 gtggccgagg ccgagcgcag ccacccggcg gtgcaggccg actgggtacg gatccgcgca
     4021 cacgccgccc cggcgctgat cgaacgttcc gccgacgccg ccctgctcgt ggtcggcggg
     4081 cgcgggcaca gcgcggtggc cggactgctc ggctcggtcg ccgccgcggt cggcgcccac
     4141 gcccactgcc cggtcgtgat cgcccggggc gacccggacc cggccgcccc ggtggtcgcc
     4201 ggggtcgacg actcccccgc cgcggccgcg gtgctgcgct tcgcggccga gcacgcgctg
     4261 gcccggggcg tgccgctgcg ggtgatccgt gcctggccgc cggtgaccgg gctgttcgag
     4321 gacgcgtcgt gggcggctcg cacggtgccc gcctcgctgc gggagccgtt cgacgcgctg
     4381 gtgaccgaga tccgggacgc gtatcccggg ctgcaggtgc gggccgaggc cgtaccggac
     4441 gatccgggcg gcgcgctgga gcgggccgcg gccggggcgc agttgctggt ggccggcagt
     4501 cgcggcctgg gcccggtccg gggcctgctg gccggctcgg tgagccagcg cctgctgcgc
     4561 cacagcccgt gcccggtggc ggtgctgcac accacctgag cgagcgccgg cccggtggcc
     4621 gcatcgaccg gtgcggccac cgtggcgtca tcacccggcg cggtcgaaca gcgccatcgt
     4681 ctcgtccagc cgcttccggg cccagtcgta gttgtccgtg ccggggaagt tccggtacgc
     4741 cgtctcgatc gtcatgatga gcgcgaggta caggcagtac aggcggcggc gtacccgctc
     4801 gtccggggtc gacgggccgt ggccgtaacc gcggatgaac gccgacgagt cgccgtacgc
     4861 gggcacctcg ctcccggtga aaccggcctc gatcagcggg tcgccgaaga gggcccgctc
     4921 atggtcgatg atcgcgacga tccggccgtc ccggaccatc acgttgttgt cccacatgtc
     4981 ccactcgacg aaccgcggct cggtcacctc gtcgagcgcg ccggcgtgcg ccgcgatcac
     5041 ctcgcgcacc atccggtagt cgtggccgag gtccacgtcg cggcgctcgc cgtcacccag
     5101 cacgtcctcg atcatccggg tgaaggccgc ccgccaggtc gggaagcccg ggccggccag
     5161 cgggccgaag gccgcgccgc ggatggtgtt gagctcgcgg ttgagcgcgc cgagcgcctc
     5221 gtcgtaggcg gcgcgctggg cgggcgtgtg ccggtcgcgc aacataccga ggttgtccgc
     5281 gtcgatgtac ggcatgacga accagtccgc gtcgcacagc cggtggccgc ggtcggcgta
     5341 ctcgacggcc ggcaccggcg cggtggtgtg ctcgcggatc aggcgcagcg cggtcagctc
     5401 ggtggccatc gcgccgcgct cgtaggtcat cacctccacg gccggcggcg gggcgatctt
     5461 gagaacgacc tcgcgtccgg agcgcagccg gatccggtag gcgacgttga accagccgtg
     5521 gcccagctcg ctgcaccagt cgccgccggc cgggacctcg cccggcccgt aggcgcgctc
     5581 gatcatcgcc tggagcacgt ccgggcgctg ccggttcttg gtgatgctgt ccatgacggg
     5641 cctccgcgga accggtgcga cggggatgag agcgctctcc tgcccggcca acctagcggc
     5701 tgcctggccg cacggaaagg ccgccacccg accggccgcc gagcgacgat gccgctgcgg
     5761 gccgctggaa caccgccgcg gcgggcgcgc ccggcggcgg tgcagcggcc ggaggcgccg
     5821 ccgggccggc aaggtcagtg gaccagcgcg tccggcgcga tgccggcggt ggagccgtcc
     5881 cggccgtacg ccgtcaggct cccgatcgtg ctggccgcga tgttgcgcag cgcgtcctcg
     5941 gtgaagaacg cctggtggcc ggtgatcagc acgttcggga aggagaccag gcgggtgaac
     6001 aggtcgtcgc tgagcacctg gtcggagagg tcctcgaaga acagcgccgc ctcctcctcg
     6061 tacacgtcga gtccgaggtg gccgatccgg ccgctcatca ggccccggat caccgccgcg
     6121 gtgtcgacca gggccccgcg gctggtgttg atcagcatga cgccctcgcg catcatcgcg
     6181 atgcgcgact cgtcgatcag gtggtgcgtc tccggggtca acgggcagtg cagggtgacg
     6241 acgtcggact cggcgagcag cgtctccagc ggcacgtagg tggcgcccgc ctcgatcgcc
     6301 tcccgcgccg ggtacgggtc ggtggccagc acccggcagc cgaacccggc catgatccgg
     6361 atgaagcaca cgccgatctt gccggtgccg accaccccga cggtacggcc gtgcaggtcg
     6421 aagccgagca gcccgttgag cgcgaagttg tgctcgcgca cccggttgta cgcccggtgg
     6481 atgcgccggt tgagcgccag caccagaccc gcgcagtgct cggccaccgc gtacggcgaa
     6541 tagcccggca cccgggtgac cgcgagcccc agccggcgcg cggcgcccag gtcgacgtgg
     6601 ttgtaaccgg ccgagcgcag cgcgaccatc cgcaccccgg ccgtggcgag gcgctcgagc
     6661 accggcgcgc cgagatcgtc gttgacgaac gcgcagaccg cgtcgcagcc gaccgccagc
     6721 gacgcggtgt ccggggtgag ccggggttcc aggaaggtca gctcgtgccc ggcctcgtgg
     6781 ttggcctcgc tgaggaaccg gctgtcatac ggctttgtgc tgaacaccgc aacgcgcatg
     6841 atcgacaccc taaccgcccg gccgatcacg gatcggccgg gcggttacgg atgtgcgggg
     6901 atcagaccag gtcgaagcgg tccagctcca tgaccttgac ccaggccgcg acgaagtcgg
     6961 tgacgaactt ctcgcgggcg tcgtcgctgg cgtagacctc ggcgagagcc cgcagctgcg
     7021 agttcgagcc gaagatcagg tccaccgcgg tggcggtcca cttcacctgg tcggtggcca
     7081 ggtcgcggat ctcgtacacg tgctcctcgg actccgacgc cttccaccgg gtgcccgggg
     7141 acagcaggtt gacgaagaag tcgttggtca gcgcgcccgg cttgtcggtc agcacgccgt
     7201 gctgcgagcc gccgaagttc gcgccgaggc tgcgcaggcc gcccagcagg acggtcatct
     7261 ccggcgcggt caggttcagc atgtaggcgc ggtcgacgag cagcacctcc ggctgggtct
     7321 tctcacccgg gcgcaggtag ttgcggaaac cgtcggcgcg cggctcgagc acccggaacg
     7381 actcgacgtc ggtctgctcc tggctggcgt cggtgcgacc cgggtggaac ggcacggtca
     7441 cctcgacgcc ggcgtcgcgc gccgccttct cgaccgcggc cgaaccggcc agcacgatca
     7501 ggtcggccag cgagatcttc gcgccgccgg ccgcgttgaa ctcctgctgg atgccctcca
     7561 gggtggccag cacggtggcc agctgctccg gctggttgac ctcccagttg cgctgcggct
     7621 cgagccggat gcgcgcgccg ttggcgccac cgcgcttgtc ggtggagcgg aagctggccg
     7681 ccgaggccca ggcggtggag atcagctggg cggtgctcag gccggactcc aggaccttcg
     7741 ccttgagggc ggcgacgtcg gtgtcggtga ccagcgggtg gtcgacggcc ggcaccgggt
     7801 cctgccacag ctgctgctcc ggcacccacg ggccgaggaa gcggctgacc gggcccatgt
     7861 cacggtgcag cagcttgtac cacgccttgg cgaacgcgag cgcgaactcg tccgggttct
     7921 ccaggaagcg gcgggagatc ttctcgtaca ccgggtcgac gcgcagcgac aggtcggtcg
     7981 tcagcatcgt cggcttgtgc ttcttcgacg ggtcgtgcgc gtccgggatg atcgcctcgg
     8041 cgtccttggc gacccactgc ttggcgccac cggggctggt ggtcagctcc cactcgtagc
     8101 cgaagaggat ctcgaagaag cggttgctcc actcggtcgg cttgtcggtc caggtgacct
     8161 cgaggccgct ggtgatggtg tcgccgccct tgccggcgcc gtgcgtgctg agccagccca
     8221 ggccctgcgc ctccagcggg gcggcctccg gctccgggcc cacgtggtcg ttggccaccg
     8281 cggcgccgtg ggtcttgccg aaggtgtgcc caccggcgat gagcgcgacg gtctcctcgt
     8341 cgttcatcgc catccgggcg aaggtctccc ggatgaagtg cgccgccgcc aacgggtcgg
     8401 cgttgccgcg cgggccctcc gggttgacgt agatcaggcc catctcggtg gcgccgacgt
     8461 ccgcggccat ctccttgtcg gagacgtagc gctcgtcgcc gagccaggtg tcctccggac
     8521 cccagaagat ctcctcgggc tcccagacgt cgacgcgacc gaagccgaag ccgaaggtct
     8581 tgaagcccat cgactccagg gccacgttgc cggccagcac cagcaggtcg gcccaggaga
     8641 tcttctggcc gtacttctgc ttcaccggcc acagcaggcg gcgcgccttg tccaggttgg
     8701 cgttgtccgg ccagctgttg agcggggcga accgctgccc gccgtcaccg gcgccgccgc
     8761 ggccgtcgtg gatgcggtag gtgccggccg cgtgccagct catccggatc atcaggccgc
     8821 cgtagtggcc gaagtcggcc ggccaccagt cctgcgaggt ggtcagcgtc tcgatgatgt
     8881 cgcgtttgag ggcctcgacg tcgagcttgg cgaactcctt ggcgtacgcg aagtccgggc
     8941 ccagcgggtt gcccttgctg gagtgggcgt gcagcaccga caggtcgagc tggttgggcc
     9001 accagtcccg gttgctccgc gggcgcccgc cggtcttcgg ggtcggcgag gagatgcccg
     9061 ggttctcgct ctcgctgccc tgcgacgtca cggagtcgtg cgcgaccggg cacccggccg
     9121 ccgccttctt gtccacgcct tgcgcgctgg ccggcgcgtt gtcctggatg tcgctcattt
     9181 gtttccttcc gaactggcgg atcactcggg agtgcggttg gtcacgcaat cggggcaggt
     9241 gccccagaag acgacctccg cctcgtcgac caggaagccg tagtcgtcgg aggcggtgag
     9301 gcagggggca tggccgacag cgcagtcgac gtcggcgatc gcaccgcacg aacggcacac
     9361 gacgtggtgg tggttgtccc gcacccgcat ctcgtagcgg gcggtcgcgc cggcaggctg
     9421 gatgcgccgc accagaccgg tgtcggtgag cgcacgcagc acatcgtaga ccgcctggtg
     9481 ggagaccgaa gggagatcct cgcgcaccag cgcgatcacc gtgtcggtgt cgatgtgggg
     9541 gtggtcacgc agcgcggtga gcaccgccag ccgcggccgg gtcacacgca acgagaccgc
     9601 ccgaagctgc gcctcgaagc cggccgtcat gccgatgacc atagtcggct tttctggaat
     9661 taatcaagtt tccccacccg cgggaggcgg atcccacacc tccgccgcgc ggccggccgc
     9721 cggacccgcg tgccacgcgc cggggtgcgc gtcgcggccg caccggcccg gcccgcggcg
     9781 cggtgacaac acgtcgaggg tcttctattg ttgggctgtt gtcgtcgagc ctctgggagc
     9841 aggaacgtgg atctcatcga ggaccaacgc cgggaccttg cgccgctgga ggacctgcgc
     9901 cgcacgccgc tgggcggcat cgacccgcgc cgggcggccg aggtggcccg ggcccagacc
     9961 cgtgacgagg ccgagcgcgg ccggatcgac tcggcgctct ttggctccgc catctagccc
    10021 gatcagccag tacgttctga agatcgccag ccggtgcgat ctgaagtgcg actactgcta
    10081 cgtctacgag cacgccgacc agggctggcg ccggcagcct ccacagatgg agccggccac
    10141 cgtgaccgcc gtcgcgcggc gcatcgccga gcacgccgag cggcaccgcc tgccgaccgt
    10201 gcgggtggtg ctgcacggcg gtgagccgct gctggtcggc gcccgccgcc tggacgagat
    10261 cgccgccgag ctgcacgcca tcgtcggccc gcggctggac ctgcggatgc agaccaacgg
    10321 ggtgctgctg accgaggaga tctgccacat cgcgaagcgg cggcggatcc ggatcggcgt
    10381 gtcgctcgac ggggacctcg ccgcccacga ccggcaccgc cggttcgcgc acggcggcgg
    10441 cagccaccgg cacgtgctgc gcgccctgtc gctgctgcgc gccgagccga accgggccgc
    10501 ctacgccggc ctgttgtgca ccgtcgacct gcgcaacgac ccgctgcggg tgtaccacgc
    10561 gctgctggcc cagcagccgc cccggatcga cttcctgctg ccgcacgcca cctgggacaa
    10621 cccgccgccg ggggccgggg ccacgccgta cgcgcgctgg ttgtcggcgg tgttccgccg
    10681 gtggacggcc gacggccggc cggtgccgat ccgcctgttc gacgccctgc tgtcgcccgg
    10741 cacggtcggc gcggaggcgg tcgggctggg cccggccgac ctggtggtga tcgagaccga
    10801 cggctcctac gagcaggtcg actcgctcaa ggtggcctac gacggggcgg ccgcgaccgg
    10861 attggacgtc ttcacctccc cggtcgacga ggtggccgcc cacccgatga tcgccgtccg
    10921 gcagaccgga ctggccgggc tcagcgccac ctgccgggcc tgcgacgtgg tggaccgctg
    10981 cggcggcggc cagttcgcgc accggttccg caccgggacc ggcttcgaca acccgtcggt
    11041 gtactgcgcc gacctgaagg aattgatcga cggcatggac gatcgggacg ccctggccac
    11101 ctgggtgcgc gacgagctgg ccggcggcgc cggcggcgcg gacgcgctcg cccagctcgc
    11161 gccggtccac gaggccatgg tccgggcccg gctggtcacc ctcgccgcgc acggcccggc
    11221 gggcacgccg ccgcccggct gggcgcagct ggtcgcgctc gacgagaccg cgcccgaggc
    11281 ggtccgggcg gtgctcaccc atccgttcgt ccggcgcggc gacgccgccc acctggccgg
    11341 tgtcgccgcc gccgcggcga tccgcgcggg cgcggagatc cgcctggcgg tgccggtcca
    11401 cgacggcctg ctcgccctgc cgacgctggg cgccctgcgc tggccggacg gcgacccggt
    11461 ggccgaggtc cgcacgttcg ccggcgggtt ccacgccggc gacgtgacgg tacgcctgga
    11521 ccggccgtcc gcgcgctggc tgccggcccg gcggttgcgc ctcggcgacg gcccgccggt
    11581 gctgctggag gacaccgacc cgctgcgcga cgcctatccc gggctgccgc tgaccggccg
    11641 gctggacgac gccgcggccg ccgcctggca gcaacgcctc gacggcgccg tggccggcct
    11701 gcgcgccgac gccccggaat acctgcccgg cctggccgcc acgctgcgcg cgatcgtgcc
    11761 gctgcggcac gacggcaccg gcacgcagcg ggccggctcg gcgcgcaccg cgttcggcgc
    11821 ggtcgcggcc actccggagg acccggacgc gctggcgttg ctgctggtcc acgaggtgca
    11881 gcacctcaag ctcggggcgg tgctggacgt ctgcccgatg ttcgacgcgc gcgacccgcg
    11941 ccgcctgccg gtgccgtggc ggccggaccc gcgcccggcc gagggcgtgc tgcagggcac
    12001 gtacgcgttc ctggcggtcg ccgacgtgtg gcgccgccgc cccggcccgg ccgccgcggc
    12061 ccgtttcacg cagctgcgcg gctggctcga cgtggtgctc gaccggctgc tcggcgccgc
    12121 cttcctgacc ccggccgggg tacggttcgc caccgcgatg cgtggcaccg tggaccgatg
    12181 gtgaaccacg acctggccga ggacctgcgc cgggccgggc tgcgaccggg cgcgaccgtg
    12241 ctggcgcact gctcgctgca cgaggtgggc tggctgccgg acggcccggc caccctgcgc
    12301 cgggcgttgc agcgggtgct caccccgggc ggcacgctgg tggtgccgac gcacacggcc
    12361 ggcaactcga acacctcgga ccagtaccgc cgcgcgaccg ccggcaagtc cgcggcggcc
    12421 cgggcggcct gggaggacgc catcgagccg ttcgacccgg acaccagccc gtcgcacgag
    12481 atggggctgc tcgccgagga cgtacgccgg cacccgggga ccctgcgcag ccggcacccg
    12541 cacacctcgt tcagcgcgct cgggccgcgg gcacgggagc tgaccgcggt gcacgacctg
    12601 gactgtcacc tgggtgagcg gtccccggtc ggcgcgctgt acgcggcgga cgcgacggtg
    12661 ctgatgatcg gggtcggcta cgaccactgc accgcgttcc acctggccga gtaccgcctg
    12721 cccaccccgc cgcggcgccg ggcgcaccgc tgctacgtgc gcgacgagcg gggcgggcgc
    12781 cgccgtgtcg acttcctcgc cccgcacctg gacgaccacg acttcccgct gctgggcgcg
    12841 gcgttcgagg gtaccggggt ggtgcgcgcc ggacgggtcg gcaacgcccg gacccggctg
    12901 ttcgagatcc gggccgccgt cgatttcgcg gtcggctgga tgaccgagca tcgtggacgc
    12961 tcgccggggt gtccggactc gcccgcggtc gatatcgtga acctccaccg ttgaggagcg
    13021 tgcgagctgg ggagcggagc atgacctcga gttcccgtac gccggtcttc ttcatcagct
    13081 acgcccaccg cccgcagcgg gcccgggcgc agcgcgacgc gcacctggtc cgcgagttct
    13141 acgacacgct gtacgggcac gtcgacgagc tgctcggcct gcaggccggg caggaggccg
    13201 gcttcatgga cgccgagctg gacggcggcc agcgctggtc cgacgacctg gcgtacgcga
    13261 tcggccactg ccaggtcctg gtcccgctga tctcgccacg cttcggcggc agcgagtggt
    13321 gcgcccggga atggcacgcc ttcgcccgcc gcccgcaccg caagttcccg aaggcgaagt
    13381 cgtcgcacgg cgccaccccg atcatcccgg tgtcctggac cccgttcccg atcgagcagc
    13441 tgcccggcga gatcgccgcg gtgcagttct tcaccccggc cgggctgccc gccccggaga
    13501 tggcgcggct gtaccaccgg gaggggctgt acggcctgct gcaactcggc gaacggggcc
    13561 tggaggtgta cgaggcggtg gtgtggaagc tggcccagtg gatcgcggac gcgttctgga
    13621 cgcacgacgt cgagatcgac gacgacgtcg acttccgcgg cctgcccacc aagttcgggg
    13681 aggacccgac gtgatcttct acctcagtca cgcgcacgcg gcccgcggcg gcggggcccc
    13741 cgacccctgg gtgcggcggt tcttcgacgc cctgtccgac gccgtgcacg cccgcaccgg
    13801 cgacggcggt ttccacgacg ggcagctggc cccgggcgcc gacagcaagc agcagctcac
    13861 cgcggccctc gggcaggccc aggtgttcgt cccgctgtac tcgccgcagt acttcaacaa
    13921 ctcgtgggcc gtggccgagc tgacctcgtt ccggtcccgg ttgcgcgggt tcgccccggc
    13981 cgaggcggcc cgccacatcg tgccggtggt ctggacgccg ctgccgccgt gggccgcgcg
    14041 ccccgaggtc gacgaggcgt tcggcctggt cggcaagtcg gtggagtact ccgagaacgg
    14101 tatgcgcgcg ctgtgcatgc tcagcgtcta ccgcgacgcg taccgcgacc tggtgacccg
    14161 gttcgccgac cggatcgccg ccgtggtcca cgagtcgccg ctggccccgt cggcggccgc
    14221 cccgccggtc ccgcgaccgc cggacaccgg cgaaccggcg ctgctggtgt ccctgctggc
    14281 cgccgagggc tccgggtacg acctgccggc gctggccggc cgggtgctgg cggcggccga
    14341 gcggctcggc gtcccggccc tgcaggcgcc gcccgaccag gtgcgccggc aggccgggcg
    14401 gcggccgtgc gtgctgctga tcgacgccgg ggccggcccg gagacggtgc gcgccacggt
    14461 caccggactg cccggctggg tgatcgcgct ggtcgtcgcg agcgcgtcgg cggcgaccgg
    14521 agcgctcacc ggtatcctgc gaaccgccgg cctgccccgg gtcagcccgg tccgcacggt
    14581 cgccgagttc gagcgcaccg ccccgctgct ggtgaccgag gcgcgcaagc agtatctgcg
    14641 gcacggaccg gtggtgaccg cacccggctc gccgcggccg agcctgcgcc ggaccgtcga
    14701 cgacaagcga ggataggggc gaccatggtg gaccgcgagg ggcagatcgt caccttctac
    14761 tcgtacaagg gcggcaccgg gcgcaccatg gcgctggcga acgtggcgtg gatcctggcc
    14821 gccaacggcc accgggtgct ggccgccgac tgggacctgg agtcccccgg cctgcaccgg
    14881 ttcttcgccc cgttcctgag ccctgagcag gtggccacca cgcgcggcgt gatcgggttg
    14941 atcaccgagt accagtgggc gaccctgccg cgcgacgagc ggggcaacgg cctgccggag
    15001 accgagcgac cggccgactg gtaccgcgag tacgccaagg ccgagcggta cgccttctcg
    15061 atcaactggg cgttccccgg cggcggctcg ctcgacgtgc tgctggccgg gcacagcagc
    15121 ctggagtacg aagccagcct gaacggcctc aactgggagg acttctacaa ccggctgggc
    15181 ggcgcgcact tcttcgacgc gctgcgcgag gacatgaaga gccgctacga ctacaccctg
    15241 ctggacagcc ggaccgggct cagcgacgtg gcggacatct gcacgatcca cctgccggac
    15301 gtgatcgtcg actgcttcac cctcagcgag cagggcatcg acggcggcgc gtcggtcgcc
    15361 gcgcagatcc gcacctacga ggacgagcgg ctgcgccgga tcctgccggt gccgatgcgg
    15421 gtcgacaacg gcgagcagtc caaggccgac gccggccgca ccctggcgag acggcgcttc
    15481 acccggctgc cggccgggat gaccgaggag gagcggcgca actactggta cgaggtggag
    15541 gtgccgtacc gcacctacta cgcgtacgag gagatgctgg ccaccttcgg cgacgagccc
    15601 ggcaacccgg ccagcctgct gtcctcgtac gagcggctga ccggttacat caccgatggg
    15661 cgggtcaacc ggatgccgcc gctggaaccg ggcctgcgcc ggcaggtggt ggcccggttc
    15721 gagcgcaaac ccgccctggt cgaggagacc ctgatgctgc ggtacgcccc gcaggaccag
    15781 gtgtgggccg agtgggcgct ggccgtctac accgccgccc ggctgcgcgt cgtcgacggc
    15841 ggccggtccg gcgagccggc cgatccgggc acccgggagg tggtgctcca ctccgacgag
    15901 ttcgccggca ccggcaaccg ttccgcggtg gcgctctgcg tcggcgacag caccccggcc
    15961 ccggacgagt tcgacgcctg ggactcgctc cacgggcacg gcgccgagtc ggcgatcggg
    16021 cgcgcgttgc ggctggtcgg cgcggacgac cggggcgccg ccgactggca cgcgacgctg
    16081 ccgcgctacc ccggcgagtt gccgcaggtg cagaatccgc cgacccgcaa cccccggttc
    16141 accggccgcg actccgagct gcgccggatc cgggagaccc tcaaacgggc cgggggcacc
    16201 ccggtggcgc tggtcggcgg cgccgggacc ggcaagtcgc agctggccat cgagtacgca
    16261 catcgcttcg ccggggccta cgacgtgatc tggtgggtgc cggccgaccc gccccagttc
    16321 gtcgagacga tcatggccga cctcggcgcc gagctgaact atccgcggcg cgcgaccctc
    16381 gacgacaccg ccggcgtggt ggtgcgccgg ctcagccgcg gcggcggccg cgagggcacc
    16441 ccgctgcgct ggctgctgat cttcgacaac gccgaccggc acgccgacat cgcccgctac
    16501 ctgccccgcg gcaacgggca cctgctggtc accacccgca acgccgagtg gggcgacgtc
    16561 gccaaggtga tcgaggtgga ggggttcagc cgcgccgaga gcatcgaaca cctgcggttc
    16621 cgcgtcggca cgcaggcgat cacccgggcc gaggcggacc gggtcgccga ggcggtcggc
    16681 gacctgccga tcctggtggt gctcgcggcc gcctggctgc acgacaccgg ccgctcggcg
    16741 caggagtacc tgtccggcct ggagaagtcc ggaacggtgc gcaacgccgc catcggggtg
    16801 tgggaggtca tcctggagcg gctgcgcgcc acctccaacg gcgcctaccg gctgctgcaa
    16861 ctggcctcgg tgctgcagcc ggacatctcg ctcagcctgc tctacagcga cgaggtggcc
    16921 cgggtcatcg cccagtacga caaggacgtg gcccgccagc tcgccgaccg gatgtccgag
    16981 cacgacgtca cgtccgccct gatgcagccg atcaaccggc tgtcgctggt caaactggac
    17041 ccggagaagc ggcgggtcac cgtgcaccgg ctgctgcaga gcgcgctgcg cgaccggatg
    17101 gcaccggaac gcctcgccga ggtccggcac gcggtgcacc gggtcctggc ccgggcccgg
    17161 ccggccggcg aggtcgagga cgcccagacc tgggacgcgt tccggctgct ctggagccac
    17221 ctggacggct ccgacccgga ggggtgccgc gacgacgacg tgcgccagct ggtgatcgac
    17281 cggatccggt acatctatct ggtcggcagc ttccggcagg gcctggacta cgcgatccgc
    17341 gccgaccggc ggtggagcgc gcagctggag accctgtcac cggacgacga ggaccggcac
    17401 gcgctgctgg tgcggctgct gcacctgcgc ttccaccgcg ggaacctgct gcgcagcctg
    17461 ggcgagttcc ggcaggcgct ggagctggac cgtgagacgc tgcgggcgca ggaggacctg
    17521 atcggcgaca gccacccgta cacgctgttc accgccggca gctacggcgc cgacctgcgc
    17581 gcgctcgggc actaccagga ggcgctgcaa cgcgacatcc tcacctaccg gctgtcggcg
    17641 gaccggttcg gcgaggacaa ccggcgcacc ctggcgttcg ccaacaacct gggcacgtcg
    17701 taccggctga ccggcgactt ccggcgggcg ctggacatgg accggaccac gctgcagcgg
    17761 atgacgcaga cgctcggcga cgatcatttc cgcaccctgc tgtccgccaa caacgtcggc
    17821 cgggacctgc gcgaggccgg cgagtaccgc gagtcggtga acctgctgcg cggcgtgcgc
    17881 cgcggcttcg agaaactgta cggtcagcac tcccgggacg cgctcagcgt gcagaccaac
    17941 ctggcggtgt cgatgcgcgg cgccgggcag gtcgacgagg cacgggagct gctcgacgag
    18001 gcctacgagc ggctcaccgt cgtcctcggc ccggagagcc cggaaaccct gatcacccgg
    18061 ctgagccggg cggccaccat gctgctgacc gaggacttcg ccacggcgcg ggcggagttc
    18121 gaacaggtcg agagcatcct ggtacgccgg ttcggcgagg ggcatccgta cgtgctgatc
    18181 ggccggcaca acctggcggt ggcgctgggc gaggccggcg cggtcgagct cgccctgccg
    18241 atcgcccgcg ccaccaccgg ggcgctgcgc gacaagctgg gtgaacggca cccggcaacg
    18301 atggccgccg agaacaacct ggcgctgttc ctgatcgagt cgggcgagcg cgagaccggc
    18361 cggcagctgc tggccgacac cgtcgaccgg ctgatctgca cactggacga ggaccacccg
    18421 gacacctacc tgagccaggg caacctcgcg ctgaccggcc ggaccgacca tctgcagatc
    18481 gccgagcagc tcgccgagcg gctcggctcc gaccacccga cggtgcggtc actgcaccgg
    18541 cggcggcgcg tctaccggat cctcgacccg cacacctact gaccggcccc gggccggcgg
    18601 ctcagcgggc caggccggcg acgaccgggc gggcggccag ccagcgcagc gtgcgcggca
    18661 gctcgggcat cgcgtcgaag tgcgcggcgc ccgggcgcac gtccagctcg gcggtgccga
    18721 tctggtgggc caggtagcgc gagtgcaccg ccggggcgaa ggtgtcctcc ccgccgtgcc
    18781 acagccgcac cggggcggtg atcgcgcgca ggtcgacctg ccagtcccgg cgcagcgcga
    18841 acaggtcgtc gatccagccg tacggcccgt tcttgatcgc gtcgcggtag gacagccgca
    18901 gctgccgccg cagcgccgcg tcgctgacca cccgctggtc ggcgacggtc atctgctcgg
    18961 tcagcagccc gagcaggaag tccggatcgg tgctgatctc ggtggcccgg cggcggatct
    19021 ccgactccag ctcggccggg tcggtcaccg ccttgctcat ctgctcgtga ttgtcgtcgt
    19081 tcatcccgtc gaaccagccg ggcgcacccg ccggggccag gctgaccagc accgcgaccc
    19141 ggatgatccg gtcacgcagc gcggcgtcgg cggcgcaggc cagcgcgtgc gggccgccgc
    19201 cggagcggcc gaccaccgag aaccggtcca gccggagcgc gtcggcgatg gcccggacgt
    19261 cctgcgcggc gtgcgccacg tcgcggccgc ggacccggtc ggagtcgccg taacccgggc
    19321 ggtcgtaagt gatcagccgg atgccgagcc ggtgcagcac gatgccgcgc ggacgggggc
    19381 cgaggcggct gccgggggtg ccgtgcagca ggacgaccgg gaaaccgtgc gctgggccga
    19441 gaacctcgaa ggcgatccgg cggccgtccc gcgggcggcg caccaaccgg gtccctgacg
    19501 cggcatcggc caccgtcacc ccgccctccc tgaaaaagct gacagcgtcc gagcctagac
    19561 ccccgtgccc cgcgtacgcc atgacgtcct gcaagtattt cagcgatggg tgccggacgc
    19621 ccgtaaccgc ccgtgccaaa ccgctgagca ggacggatat ccgccgaccg gggcacgaca
    19681 gcgccttgcc cgtacgatcc ggggccgccc tcgcgtaccg gatcgggccg gtctgtgacc
    19741 tgcgcgaccg cgtcccgcgc tgcgggaagg ccgacccacc cgcgtctacc atgtcggtaa
    19801 tgtgctcgca ctgcccgccg acagattgcc ctgaacaaac gtgacaaccg cagcgatccc
    19861 gacctccctc gtccatgccc tggccggggc gggcgtgtcc gacgtgctga ccgacacggc
    19921 acaccgagcg gcgtacgcga gcgacgcctc cctgtaccgg gtggtgccgc aggcgatcgt
    19981 ccggccgcgc cacgacgacg acgtggcggc gaccctgcgg gtctgccgcg agctcgggat
    20041 cccggtcacc gcccggggcg cgggcacctc ggtggccggc aacgcgatcg gccccggggt
    20101 gatcctcgac ttcagccggc acatgaaccg ggtgctggcc gtggacggcg aggcccgcac
    20161 cgcgcgggtg caggccggca cggtccaggc gacgctgcag gccgccgccc ggccgtacgg
    20221 gctgcggttc gggccggacc cgtcgacgca cacccgctgc accatcggcg gcatgatcgg
    20281 caacaactcg tgcggctccc ggaccctcgg ctacgggcgc acctcggaca acgtggtggc
    20341 gctgagcgcg tacaccatcg acgggcaacg gctggtcacc gatccgctgc ggggcgccga
    20401 gaagatcacc ggcgcgctgc gcgacctgat cggcgccaac ctcgcggtcg gccggaccga
    20461 gttcgcgacc ttcggccgcc aggtctccgg gtacgccgtg gagcacctgc tgccggagaa
    20521 cggtttcaac ctcaccgagt tcctggtcgg cagcgagggc acgctggccg tggtcaccga
    20581 ggcgacggtg cgcctggtcg ccgacccggc gtaccgcacg ctggtggtgc tcggctaccc
    20641 ggacttcggc gcggccggcg acgtcatccc cggcatcctg cagttccggc cgaccgcctg
    20701 cgagggcctc gaccaccgga tctgcgacgt ggtgcgcagc cggcgcggcc cggacgccgt
    20761 cccgccgctg ccggccggca ccgcgtggct gatggtcgag atcgccggtg acgacccgga
    20821 cgaggtgcgc gaccgggtgg cccggctggt cgccgccgcc ggggcggagg actcgctggt
    20881 cgtcgaggac ccggcgaagg ccgctccact gtggaagatc cgcgaggacg gcgccgggct
    20941 ggccggccgc gcgccgtccg gcctgcccgc gcacgccggg tgggaggacg ccgcggtgcc
    21001 gcccgccaag atcggcgcgt acctgcggga cttcgacgtg ctggtcgagc ggcacgggct
    21061 cagcgcgatg ccgtacgggc acctcggcga cggctgcgtg cacgtgcggc tggacttccc
    21121 gctggactcc ccgggcgggc cgggccggtt ccgggcgttc ctggaggacg cggccgacct
    21181 ggtggtcagc tacggcgggt cgctctccgg cgagcacggc gacgggcggg cccgcagcga
    21241 gctgctgagc cggatgtact cgcccgcggc gatggacctg ttccggcaga tcaagcacac
    21301 cttcgacccg gacaacctgc tgaacccggg gaacctggtg gaccccgacc cggtggacgc
    21361 gaacatccgg gtgtcgcagg cgcggaaggt caccaccggg ctggccctgg cctaccacca
    21421 cgacggcggg gatttcaacc aggccgtgca ccggtgcacc ggcgtgggca agtgccgcgc
    21481 cgacaccacc gtgctcggcg gggtgatgtg cccgtcgtac ctggccacca agaacgagaa
    21541 ggactccacc cgggggcggg cccgggtgct gcaggagatg ctcgacggtg acctcgcccc
    21601 ggactggcgg gccgaggccg tgcacgacgc gctcgacctc tgcctggcct gcaagggctg
    21661 cgcgtcggac tgcccgaccg ggatcgacat ggcggcgtac aagtccgagg tgctgcacca
    21721 gagctaccgg cgccgcctgc ggccccggtc gcactactcg ctgggctggc tgccccggtg
    21781 gtcgcggctg gcgtcccgga tgccgcgcct ggccaacctg atgaccggcc tgcccggcat
    21841 ccgccgcctc gccctgtttg cggcgggcgt ggacgcgcgg cgctccatcc cgacgttcgc
    21901 cgaccggacg ttccgggcgt cgttcacccc ggccgcgacc ggcaagccgg tcatcctgtt
    21961 cgtggacagc ttcaccgacc acttcgcgcc ggagatcgcc cgggccgcgg tcgacctgct
    22021 caccgacgcc ggctacgccc cgcagatcac cagccgtacc gcgtgctgcg gactgacctg
    22081 gatcaccacc ggccagctcg acgccgcccg gcgcatcctc ggcgccaccg tgcaggagct
    22141 gcacgaggcg gtcaagcagg gcgtcccgat cgtcgggctg gagc
//
