LOCUS       NZ_CP023865            11926 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4296972
            Orig. end                         :: 4308898
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11926
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11926
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11926
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6926](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6926
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(264..279)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            complement(541..1224)
                     /locus_tag="ACTEI_RS18990"
     CDS             complement(541..1224)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015621493.1"
                     /locus_tag="ACTEI_RS18990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /protein_id="WP_122978881.1"
                     /transl_table=11
                     /translation="MRTWTVGDVMTKAVVSVDENASYRDVVDVLIERRCSAVPVVDAGH
                     RVIGVISETDLLRKIEYAGDESARVFERRSRRGERAKASARTAAGLMSGPPVVALAGTP
                     VAAAARRMDAEHVKRLPVVDELGRLVGIVSRGDLLKTYLRPDLDIQADVENGVLRAFLV
                     DDTASVTVSVTDGVVALAGRVGRYSSAELVERLSRQVAGVVEVVSGLTYDVDDRQPVVA
                     PAPFF"
     misc_feature    complement(1331..1345)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            1355..2173
                     /locus_tag="ACTEI_RS18995"
     CDS             1355..2173
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020509821.1"
                     /locus_tag="ACTEI_RS18995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="universal stress protein"
                     /protein_id="WP_122978882.1"
                     /transl_table=11
                     /translation="MRSPAIAVATDGAESGTVAVRWAAEEARRRRLPLRVVHVLDWDWG
                     AARYDFGGGAFETARRLAATVVAVAVREARDAAPEVEVAADVLVGNPTGQLLGDTEHLG
                     LLVLGTRGAGGFAGLRLGSVSQRVATNARCPVAVIREHPDTGPVVAGVDDSPNADAVLE
                     TAFTAADDRGAALTVIRALGRSTAQLPDTAPADLAQQVTRWHDKFPGVPVELRLASDGA
                     AAALVAASHEARLVVVGSRGHGLLTNTLLGATSLQLLQHAESPILIVRRP"
     gene            2173..2685
                     /locus_tag="ACTEI_RS19000"
     CDS             2173..2685
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014443434.1"
                     /locus_tag="ACTEI_RS19000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavodoxin family protein"
                     /protein_id="WP_122978883.1"
                     /transl_table=11
                     /translation="MRALVVYESMFGNSAKVAGLVAAGLEKGYTVTLADVREMPPLTGV
                     DLLVLGGPTHAFGMSRPATRADAARQGAIREGAQEAGIREFLDRAPQLAGVAVAAFDTR
                     SNTPLPSGSAARKAMRRLRGLGGRQVLEAESFRVESARGPLVAGEEERARQWGETLALS
                     VRGPVGI"
     gene            2883..3686
                     /locus_tag="ACTEI_RS19005"
     CDS             2883..3686
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285960.1"
                     /locus_tag="ACTEI_RS19005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_122978884.1"
                     /transl_table=11
                     /translation="MKDSGIDTSVAHPARRYDYLLGGKDNFQADRQSAHEIEKRHPTAR
                     LSAQENRFFMHRAVRFMAREGIRQFLDIGTGIPTSPNTHEIAQETDPAARIVYVDNDPL
                     VLVHARALLTGTEQGRTTYIQADLRRPDAILADDDLRATLDLTRPVGLLLIAVLHFIRD
                     DDDPRAILDTLISALPSGSIVAASHATPEHMPAEQVAALRAVMERQWRDRTGTELAALF
                     DRPDLRPVAPGVQSVSRWWAEQAPQPRPAVEEVASNGLVARVVRD"
     gene            complement(3779..3982)
                     /locus_tag="ACTEI_RS19010"
     CDS             complement(3779..3982)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014690130.1"
                     /locus_tag="ACTEI_RS19010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ferredoxin"
                     /protein_id="WP_122978885.1"
                     /transl_table=11
                     /translation="MVNRVEFDEPRCIAAGQCVMTAPEVFDQRDEDGVAIVLQPEPAPE
                     HLDAVRNAVAVCPAAALQLVER"
     gene            complement(3976..4239)
                     /locus_tag="ACTEI_RS19015"
     CDS             complement(3976..4239)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS19015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_122978886.1"
                     /transl_table=11
                     /translation="MLLADRPHRWARVPADRSLSASTVEEAPRFDAGPGRGLPRCTVED
                     IEVAGCPIRAASGHLELAVPAGRLRRRAGLIVGGIEEVPAQW"
     misc_feature    complement(4552..4565)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            5001..6926
                     /locus_tag="ACTEI_RS19020"
     CDS             5001..6926
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019872099.1"
                     /locus_tag="ACTEI_RS19020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_122978887.1"
                     /sec_met_domain="TIGR03975 (E-value: 2.3e-182, bitscore:
                     606.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKITLVGMPWATIATPSLALGILARRIADAFPQADLTTVYANIDF
                     ADWMDQQGGYGSAEFNFFSLQSYFMGCGDWVFSSALYDDPQWRVDEFTRIMTGRISDRQ
                     LETSLRLHRTVPAFVDAMAHRIVADGPDLVGATSTFQQNVASLALLRRIKQLAPATMTV
                     MGGANCDGPQGEALHRNFDCLDYVVRGEAERTVVQLVEALHTTGRDDLSGIAGLCWRRD
                     GASVSNPPSRQLLSPAEIPTPDFDPYFERFRRSRVQSWFEPVLVVEGARGCWWGEKHHC
                     TFCGLNGSAMTFRSKSPHTYLEEILHLAGRHHVLDFYAVDNILEMSFLDSVLSKLAEAP
                     FDLRMQYEVKSNMTMSQIVRLRDAGVVSVQPGIENLSSRVLKIMDKGVSGTHNVRFLRD
                     AESNGMSVAWNYLYGFPGEAPEDYEPIMEQLPALHHLHPPTGANRIALERFSPYFDRPE
                     LGFAGRRPHWQYSLIYDLPDRELADLAYLFETDDQGIDAKLADRLESALEEWSGHYVLS
                     RLSYADDGARIRLVNSRPGFAWRELTLSDPTERALFHALADPRSLPHLVRLAGGPDAGW
                     PGERVAELLQDWRRLGLIFVEADRAVRLATEDENQLMLRIRHETDTSGGPELAFEQAGE
                     FTCVDI"
     gene            6911..7486
                     /locus_tag="ACTEI_RS19025"
     CDS             6911..7486
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.3"
                     /locus_tag="ACTEI_RS19025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5825 family protein"
                     /protein_id="WP_145831022.1"
                     /transl_table=11
                     /translation="MRRHLTVAPPAPAGERVRELYRGGIRSVALDEPISLRSPEPRDLH
                     ALDFVRVATARGLLVRWHLRTGRRADPELVARDLTHLQPPASLDGRGSQERLREWHRRF
                     YIGRCVWRRGPGFVQIRDRRDGVLQLFDLSEDDYVRAVLQLEQQRAAEVDPQVLDAMRD
                     ERLVLRLGDLDWWAPALIDRWPVPSMVL"
     gene            7515..7856
                     /locus_tag="ACTEI_RS19030"
     CDS             7515..7856
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS19030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_122978889.1"
                     /transl_table=11
                     /translation="MVDQIAAAVLACAVLGLLVWRGFFTPPGSFGSWAMFSHISAYRAR
                     LRDSTDDAPISPWDYELRHDHFNSAAGLGSLVTYLEQERGRHVVGEGVVLLPFRYVKVA
                     VRNGEVVRA"
     gene            7849..8778
                     /locus_tag="ACTEI_RS37140"
     CDS             7849..8778
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS37140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164466016.1"
                     /transl_table=11
                     /translation="MPDLLPIGGTTAGPALCLFRLILGVALLWKIIADHRFGMARFFDL
                     DPKSLLRWRYERDEMAVKLLLSPSAFRVFYTARAVAVGCLLAGILTPLAAGVVAAWCLF
                     EFTFDRKFNTLFLGLMCVPFVFTSGADAYLSLQSLLDSGSPAAFFTPPAPDGELTSWPQ
                     VAAVALMCQVYWSSTWYKAASRQFTSGDTLQKTFEQLASVQADLPPGRREYYFPDWFTR
                     RFATADPAVARRWRLPSLATIAVEGALPLLLIFPFTWPLGALLGLAMHAAFTSILPKRL
                     VPFGLASVGTYLLFLPQHTFVTLVGGLT"
     misc_feature    7861..7863
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8775..9554
                     /locus_tag="ACTEI_RS37145"
     CDS             8775..9554
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="ACTEI_RS37145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_164466017.1"
                     /transl_table=11
                     /translation="MTDPAVRAADSFGARAREYDRLRPGYPAEALTTAVAAQGGARPGP
                     ALDIGCGTGKLAGALRGLGYDVLGVEPDPRMAAVATANGVAVEVAAFEDWDDAGRRFGT
                     VACGQAWHWLRPGYRSRRAARLLRPGGNLLLAWNFGTLNPLIARGLHRVYAGLLPDGLP
                     AGQDGLADLDESDAANYARELREHGLRNVTTTVLPWYEVLTGQQWCDLLSTESRHLALP
                     EGTRRRLLREVGRFLDRNGGRIRVDYRCTLVSATAEG"
     gene            complement(9558..10847)
                     /locus_tag="ACTEI_RS19040"
     CDS             complement(9558..10847)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="ACTEI_RS19040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_164466018.1"
                     /transl_table=11
                     /translation="MVHGQRRPTARQPRKSAPLWRNRDYNLWWSGTALSRLGSSISALA
                     LPLLVLAFTGSAAAAGLVGTCAAVGLLAGLLPAGVAADRYPRRRLLAGAALVQAAGAAA
                     LCSIAAAGRLWLPLVTALALIQGLASAVFNAAASPLVKRIVAAEQLKAAFTRAEARDYG
                     AQLAGAPLGGLLFTLARWAPFLADALSFVAVALTAVLLRTPLGPDTGEPPDPARTPIRR
                     DLMSGLSHIRRGPFLRYALLWSALTNMLFAGIGFLFVVALRENGASPSTIGAAEAIATG
                     CGLAGTLATEWVVRRVPGDRIVLAVSWMVAAGVGGLVLLADRPWLAALCLGVSIAFVTP
                     LNVVFATRVVTTVPDAMTARVLTSMNLAAMGFAWPAPLLCGVLADAYGADVPLIAIAAG
                     LAVMAVVNHLAPAVRQLAAEPGARNPATAG"
     gene            complement(10984..11820)
                     /locus_tag="ACTEI_RS19045"
     CDS             complement(10984..11820)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (18-257). E-value:
                     1.9e-09. Score: 29.5. Matches aSDomain:
                     nrpspksdomains_ACTEI_RS19045_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020512386.1"
                     /locus_tag="ACTEI_RS19045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_122978891.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.6e-17, bitscore:
                     61.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLQTDLDRVEAANAGGKPPVVFIHGLWLLPSSWQRWAEVFAAAG
                     YAPVVAGWPDDPETVEEANAHPEVFARKSVGQVADHFCDLIGRLDRKPAVVGHSFGGLI
                     TQIVAGRGLSAASVAIDPAPFRGVLPLPISALRVASAVLGNPANYHRAVPLTYEQFRYG
                     FANAVTEEEARELYATYAVPASGEPLFQAAAANFNPWSEARVDTGNPDRGPLLIISGER
                     DHTVPWSIANASYRQQRDNPGVTEIVEIENRGHSLTIDSGWREVADTALAFVERFH"
     aSDomain        complement(11050..11766)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTEI_RS19045_Abhydrolase_1.1"
                     /evalue="1.90E-09"
                     /label="ACTEI_RS19045_Abhydrolase_1.1"
                     /locus_tag="ACTEI_RS19045"
                     /protein_end="257"
                     /protein_start="18"
                     /score="29.5"
                     /tool="antismash"
                     /translation="PPVVFIHGLWLLPSSWQRWAEVFAAAGYAPVVAGWPDDPETVEEA
                     NAHPEVFARKSVGQVADHFCDLIGRLDRKPAVVGHSFGGLITQIVAGRGLSAASVAIDP
                     APFRGVLPLPISALRVASAVLGNPANYHRAVPLTYEQFRYGFANAVTEEEARELYATYA
                     VPASGEPLFQAAAANFNPWSEARVDTGNPDRGPLLIISGERDHTVPWSIANASYRQQRD
                     NPGVTEIVEIENRGHSL"
     CDS_motif       complement(11491..11541)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTEI_RS19045_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="ACTEI_RS19045"
                     /protein_end="110"
                     /protein_start="93"
                     /score="10.9"
                     /tool="antismash"
                     /translation="AVVGHSFGGLITQIVAG"
ORIGIN
        1 aaggcgaagg ccgccgagca gacgctgcag gccgacatcc tccggctcac caacgagcag
       61 cgcaccgcgc acggctgcgc cccgctggcc gagaacgccg cgctgaccgc ggccgctcgc
      121 gggcacagcg cgtggatggg cacgagcggc acgttctcgc acaccggccg gggcggctcg
      181 gacttcgtcg cccgcgcccg ggcggccggt tacgccaagc cgtcggcgga gaacatcgcg
      241 tggggttacc gcagcgccga cgaggtggtc gacacctgga tgcacagccc gggtcaccgc
      301 cgcaacatcc tcaactgccg gtcgacgacg gtcggtgtcg gcgcggtcta cgccgccagc
      361 ggcgccccgt attacaccca ggacttcggc tactgagcgg ccggcacgtc gatgggccga
      421 tcccggcccg tcgacgtgcc ggccccgtca tccggcccgc ccagggcggc ggcgtcgacg
      481 aggtgaccgc atccggcgcc gccgcgccgg cgatcccgca ccgcggccca ggaccaccgg
      541 tcagaagaac ggcgcgggcg ccaccaccgg ctggcggtcg tcgacgtcgt acgtcaggcc
      601 ggagaccacc tcgaccaccc cggcgacctg gcgcgacagc cgctccacca gctccgccga
      661 ggagtaccgc ccgacgcgcc cggccagcgc caccaccccg tcggtgaccg acacggtcac
      721 gctcgcggtg tcgtcgacca ggaacgcccg cagcaccccg ttctccacgt ccgcctggat
      781 gtccaggtcc gggcgcaggt acgtcttcag caggtcgccg cgcgacacga tgccgaccag
      841 gcgtccgagc tcgtcgacga ccgggagccg cttgacgtgc tcggcgtcca tccggcgggc
      901 ggccgccgcg accggggtcc cggccagcgc caccaccggc ggcccgctca tcaacccggc
      961 cgcggtgcgg gcggacgcct tggcccgctc gccgcgccgg ctgcggcgct cgaagacccg
     1021 cgcggactcg tcgccggcgt actcgatctt gcggagcagg tcggtctcgg agatcacgcc
     1081 gatcacccgg tgcccggcgt ccaccaccgg gacggcgctg caccgccgct cgatgagcac
     1141 gtccaccacg tcccggtagg aggcgttctc atccacggac acgacggcct tggtcatcac
     1201 gtcgcccacg gtccaggtcc tcatcacgat ccctccctcg gttcgtgcct ccactctggt
     1261 ccgcacaccg tcccctcggt cagggccaca ggtcccgccc gttgcggccc ggtcggctct
     1321 gcccgccgcc atcgacccgg atgatcatcg gggtatgcgt tcaccagcca tcgccgtcgc
     1381 caccgacggc gccgagtcgg gcacggtcgc ggtccgctgg gcggccgagg aggcacgccg
     1441 gcggcgcctg ccgctgcgcg tggtccacgt gctggactgg gactggggcg ccgcgcgcta
     1501 cgacttcggc ggtggcgcgt tcgagacggc ccgacggctg gccgcgacgg tggtggcggt
     1561 cgccgtgcgt gaggcccgcg acgccgcgcc cgaggtcgag gtggcggccg acgtgctggt
     1621 cggcaacccg accggccagt tgctcggcga caccgagcac ctcgggctgc tggtgctcgg
     1681 cacccgcggc gcgggcggct tcgccgggct gcggctcggt tcggtcagcc agcgggtcgc
     1741 caccaacgcc cgctgcccgg tcgcggtgat ccgcgagcac ccggacaccg ggccggtggt
     1801 cgccggtgtg gacgactcgc ccaacgccga cgcggtgctg gagacggcgt tcaccgccgc
     1861 ggacgaccgc ggcgccgcac tgaccgtgat ccgcgcgctc ggccggtcca ccgcgcagct
     1921 gccggacacg gcgcccgccg acctggcgca gcaggtgacg cggtggcacg acaagttccc
     1981 cggcgtgccg gtggagctgc ggctggcgag cgacggcgcg gcggcggccc tggtcgccgc
     2041 ctcgcacgag gcgcgtctgg tggtcgtcgg cagccgcggc cacggcctgc tcaccaacac
     2101 tctgctcggc gcgaccagcc tgcagttgct gcagcacgcc gagagcccga tcctgatcgt
     2161 ccggaggccc tgatgcgcgc acttgtcgtc tacgaatcga tgttcggcaa cagtgccaag
     2221 gtggccgggc tggtcgccgc cgggctggag aagggctaca cggtcaccct ggccgacgtc
     2281 cgggagatgc ccccgctgac cggcgtcgac ctgctggttc tcggcggccc gacgcacgcg
     2341 ttcgggatga gccggccggc cacccgggct gacgcggccc ggcagggcgc cattcgcgag
     2401 ggcgcgcagg aggccgggat ccgcgagttc ctggaccggg cgccgcagct ggccggggtg
     2461 gcggtggccg ctttcgacac ccggtcgaac acgccgctgc cgtccggctc ggcggcccgc
     2521 aaggcgatgc gccggctgcg cggcctgggc gggcggcagg tgctggaggc ggagagtttc
     2581 cgggtcgagt cggcgcgggg cccgctggtg gccggcgagg aggagcgggc ccggcagtgg
     2641 ggcgagacgc tggcgctctc ggtacgcggc ccggtcggca tctgaggcga cgccccgctg
     2701 tccgcgcggg gcgtcgtgcc ggtccacccg cgcaccggtc caccggacgc cgagtcggca
     2761 aggccgaccg gcaaggctcg gccggcgttt ccggtaccgg gcggcgacgg ctggcagcaa
     2821 ttgactacga tcctcgtgat tcgcctggcc ggtgcggaag gggacttttg gtgactgatc
     2881 cgatgaagga ttccggtatc gacacctcgg tcgcccatcc cgctcgccgc tacgactacc
     2941 tgctcggcgg caaggacaac ttccaggccg accggcagtc cgcgcacgag atcgagaagc
     3001 ggcaccccac cgcgcggctg agcgcccagg agaaccggtt cttcatgcac cgtgccgtgc
     3061 ggttcatggc ccgcgagggc atccgccagt tcctggacat cggcaccggt atcccgacct
     3121 cgccgaacac ccacgagatc gcccaggaga ccgacccggc ggcccggatc gtctacgtcg
     3181 acaacgaccc gctcgtgctg gtccacgcgc gcgccctgct gaccggcacc gagcagggcc
     3241 gcaccacgta catccaggcc gacctgcgcc ggcccgacgc gatcctggcc gacgacgacc
     3301 tgcgggccac cctggacctg acccggccgg tcggcctgct gctgatcgcc gtcctgcact
     3361 tcatccggga cgacgacgac ccgcgcgcca tcctggacac gctgatctcg gcgttgccgt
     3421 ccgggagcat cgtcgccgcc tcgcacgcca ccccggagca catgcccgcc gagcaggtgg
     3481 ccgcgctgcg cgcggtgatg gaacggcagt ggcgcgaccg caccggcacc gagctggccg
     3541 ccctgttcga ccggcccgac ctgcgaccgg tcgcgccggg cgtgcagtcg gtctcgcgct
     3601 ggtgggccga gcaggccccg cagccgcgac cggcggtcga ggaggtcgcc tccaacggcc
     3661 tggtcgcccg ggtcgtccgc gactaaggtc cgggccggag cggccgcccg gccggtgacc
     3721 cgcccagcgg gcctccacct gcggtgacgc tccgccttgg agcgttatgg cggtccggtc
     3781 accgctcgac cagctgcagc gcggccgccg ggcagaccgc gacggcgttg cgcaccgcgt
     3841 ccaggtgttc cggggccggt tcgggctgca ggacgatcgc cacgccgtcc tcgtcgcgct
     3901 ggtcgaagac ctccggcgcg gtcatcacgc actggccggc ggcgatgcac cggggctcgt
     3961 cgaactcgac tctgttcacc actgggccgg aacctcctcg atgccgccga cgatcagccc
     4021 ggcgcggcgg cgtagtcggc cggccgggac ggccagctcc agatggccgc tggccgcccg
     4081 gatcgggcaa ccggcgacct cgatgtcctc aacggtgcag cgcggcagcc cgcggccggg
     4141 gccggcgtcg aagcgcggcg cctcctcgac cgtcgaggcg ctcagggagc ggtcggcggg
     4201 cacccgcgcc cagcggtgcg ggcggtcggc cagcagcatc gcgtcctcct catcgtccgg
     4261 tcacggccga ccgtaggtga gccgcccgcc cgggacaaga ccgtcccggc ggtcagcccg
     4321 ctcaccagca acgatgccgc accggcagct ggacacgggc ggcagcggct ccggcgcgcc
     4381 cgggacgcgc gccggcttgc ggccccgtcc cggtacggcc ggggcagcgg cgatcggttc
     4441 cggtcgcggg tccgcgcaac cggcgccgac ggggtcggac cccacctgct gaaaccggcg
     4501 atgaccggca cgccgttgga gccggtcagc tagtcgttgg gcggatgtga cctgatccgc
     4561 ggcaactgaa atatcgactt acatccatgt tggcttactc cgagtgggtg caagactgcg
     4621 tcgcgtgatg attcggcccg cgacccacga ccgcgttggt gtcgcggccg gcgggtcgac
     4681 atccgccgga ggccatggcg tgagcggcta ggacgccgcc gcccgcggtc gtcgtgccga
     4741 tccgacgccc gccggcctcg tcccccgaga ttccggcact cccgcacgcc tgagtgccgg
     4801 cttcaccgag cagcgagagg aggaaaccat gcagaagagc gtcgtgctca acgatccgca
     4861 gtccgaacgg agtgtcgcgt ccgtcgaggt cagcgtgacg gtgaagttct gatccggaac
     4921 gcctgaaccg gacggccggt cacgcgttcc cggtgcggtc accgatcgca ccgggaacgt
     4981 caggtccctt tggagagctg atgaaaatca cactggtagg catgccgtgg gccacgatcg
     5041 ccaccccgtc gctggccctg ggcattctcg cgcgacgcat cgcggacgct ttcccgcagg
     5101 ccgacctgac gaccgtctac gcgaacatcg acttcgcgga ctggatggac cagcagggcg
     5161 gatacggctc cgcggagttc aacttcttct cgctgcagag ctacttcatg ggctgcggcg
     5221 actgggtgtt ctcctcggcc ctgtacgacg acccgcagtg gcgggtcgac gaattcacca
     5281 ggatcatgac cggccggatc agcgaccgcc agctcgagac gtcgctccgg ttgcaccgca
     5341 ccgtgccggc cttcgtcgac gcgatggccc accgcatcgt cgccgacggc cccgacctgg
     5401 tcggcgccac ctcgacgttc cagcagaacg tcgcctcgct ggcgctgctg cgccggatca
     5461 aacaactggc gccggccacc atgacggtga tgggcggcgc gaactgcgac ggcccgcagg
     5521 gcgaggcgct gcaccgcaac ttcgactgcc tcgactacgt cgtacgcggc gaggcggaac
     5581 gcaccgtcgt ccagctggtc gaggcgctgc acaccaccgg ccgcgacgac ctgtccggca
     5641 tcgccggact gtgctggcgg cgcgacggcg cgagtgtgag caacccgccg agccggcaac
     5701 tgctgtcgcc ggcggagatt cccacccccg acttcgaccc gtacttcgag cggttccggc
     5761 gctcgcgggt gcagtcctgg ttcgagcccg tgctggtcgt cgagggcgcg cgcggctgct
     5821 ggtggggcga gaagcaccac tgcacgttct gcgggctcaa cggctcggcg atgacgttcc
     5881 gcagcaagag cccgcacacc tacctcgagg agatcctgca cctggccggc cgccaccacg
     5941 tgctggactt ctacgcggtg gacaacatcc tggagatgtc gttcctggac tcggtgctgt
     6001 ccaagctcgc cgaggccccg ttcgacctgc ggatgcagta cgaggtcaag tcgaacatga
     6061 ccatgtcgca gatcgtgcgg ttgcgcgacg ccggggtggt cagtgtccag cccgggatcg
     6121 agaacctgag ctcccgggtc ctgaagatca tggacaaggg cgtcagcggc acccacaacg
     6181 tgcggttcct gcgcgacgcg gagagcaacg ggatgtcggt ggcctggaac tacctgtacg
     6241 gcttccccgg cgaggcgccc gaggactacg agccgatcat ggagcagctg ccggccctgc
     6301 accacctgca cccgccgacc ggcgcgaacc gaatcgccct ggaacggttc agcccctact
     6361 tcgaccggcc cgagctgggc ttcgccggcc ggcgcccgca ctggcagtac tcgctcatct
     6421 acgatctgcc cgaccgcgag ctggccgacc tggcgtacct gttcgagacc gacgaccagg
     6481 gcatcgacgc gaagctggcg gaccggctgg agagcgctct ggaggaatgg tcgggccact
     6541 acgtcctgag caggctgagc tatgccgacg acggcgcgcg gatccggctc gtcaactccc
     6601 ggcccgggtt cgcctggcgc gagctgaccc tgtcggaccc caccgagcgg gcgctgttcc
     6661 acgccctggc cgacccccga tccctgccgc acctggtccg cctcgccggt ggcccggacg
     6721 ccggatggcc cggggaacgg gtcgccgagc tgctgcaaga ctggcgccgg ctcgggctga
     6781 tcttcgtcga ggccgatcgt gcggtgcggc tggccaccga ggacgagaac cagttgatgc
     6841 tgcggatccg gcacgagacg gacacgtccg gcggtccgga gctggcgttc gagcaggccg
     6901 gggagttcac gtgcgtagac atctgacggt ggccccgccg gcgccggccg gcgagcgggt
     6961 gcgggagctg taccgcggcg ggatccggtc ggtggcgctg gacgagccga tctcgctgcg
     7021 ctcccccgag ccgcgcgacc tgcacgccct cgacttcgtc cgggtcgcca ccgcgcgcgg
     7081 gctgctggtg cgctggcacc tgcgtaccgg ccggcgggcc gacccggagc tcgtcgcccg
     7141 ggacctgacc cacctgcagc cgccggcctc cctggacggc cgggggtcgc aggagcggct
     7201 gcgcgagtgg caccgcaggt tctacatcgg gcgctgcgtc tggcgccggg gccccgggtt
     7261 cgtgcagatc cgggatcgcc gcgacggcgt gctgcaactg ttcgacctgt ccgaggacga
     7321 ctacgtgcgc gcggtcctgc agctggaaca gcagcgggcc gcggaggtcg acccgcaggt
     7381 gctggacgcg atgcgcgacg aacggctggt gctgcgcctg ggcgacctgg actggtgggc
     7441 gcccgctttg atcgaccgct ggccggtgcc gtcgatggtg ctgtgaccgt tgcgacgagg
     7501 gacgaggaga cgacgtggtc gaccagatcg ccgccgcggt gctggcctgc gcggtgctgg
     7561 gcctgctggt gtggcgcgga ttcttcaccc cgcccggctc gttcgggtcc tgggcgatgt
     7621 tctcgcacat cagcgcgtac cgggcccggc tgcgcgacag caccgacgac gcgccgatct
     7681 ccccgtggga ctacgagctg cgacacgacc acttcaactc cgccgccggt ctcggctcgc
     7741 tggtgaccta cctggagcag gagcgcggcc ggcacgtggt cggcgagggc gtcgtgctgc
     7801 tgccgttccg ctacgtgaag gtcgcggtcc gcaacggcga ggtggtccgt gcctgacctg
     7861 ttacccatcg gcggtacgac ggccggtccg gcgctgtgcc tgttccgcct gatcctgggc
     7921 gtcgccctgc tctggaagat catcgcggat caccggttcg gcatggcccg gttcttcgac
     7981 ctcgatccga agtcgctgct gcgctggcgc tacgagcgcg acgagatggc cgtgaagctg
     8041 ctgctgagcc cctcggcgtt ccgggtgttc tacaccgccc gggcggtggc ggtgggctgc
     8101 ctgctcgccg ggatcctgac cccgctggcg gccggcgtgg tggccgcctg gtgcctgttc
     8161 gagttcacgt tcgaccgcaa gttcaacacg ctgttcctgg gcctgatgtg cgtgccgttc
     8221 gtcttcacct ccggggccga cgcgtatctg agcctgcagt cgctgctgga ctccggctcc
     8281 ccggcggcgt tcttcacccc gcccgccccg gacggcgagc tgacctcctg gccgcaggtc
     8341 gccgccgtgg cgctgatgtg ccaggtgtac tggagcagca cctggtacaa ggccgcgtcc
     8401 cgccaattca ccagcggcga caccctccag aagaccttcg agcagctggc ctccgtgcag
     8461 gcggacctgc cgccggggcg ccgggagtac tacttcccgg actggttcac ccgccgcttc
     8521 gccaccgccg atccggccgt cgcccgccgc tggcgactgc cctcgctggc gaccatcgcg
     8581 gtggagggcg cgctgccgct gctgctgatc ttcccgttca cctggccgct gggcgcgctg
     8641 ctcggcctgg cgatgcacgc cgcgttcacc tcgatcctgc cgaaacggct ggtgcccttc
     8701 gggctcgcct cggtcggcac ctacctgctc ttcctgccgc agcacacgtt cgtgaccctg
     8761 gtcggaggac tgacgtgacg gaccccgccg tgcgggccgc ggacagcttc ggcgcccgtg
     8821 cccgcgagta cgaccggctg cgccccggct accccgccga ggcgctgacc acggccgtcg
     8881 ccgcgcaggg cggggcccgg ccgggccccg ccctggacat cggctgcggc accggcaaac
     8941 tcgccggcgc gctgcgcggg ctgggatacg acgtgctcgg cgtggaaccg gacccgcgga
     9001 tggccgcggt cgccacggcg aacggggtgg cggtggaggt cgccgcgttc gaggactggg
     9061 acgacgccgg acgccggttc ggcacggtcg cgtgcgggca ggcgtggcac tggctgcgtc
     9121 ccggataccg gtcccggcgg gcggcgcggc tgctgcgccc gggcgggaac ctgctgctgg
     9181 cctggaactt cggcacgctg aacccgctga tcgcgcgtgg tctccaccgg gtctacgccg
     9241 gcctcctgcc cgacgggctg ccggccgggc aggacggcct ggcggacctg gacgagtccg
     9301 acgcggcgaa ctacgcgcgc gagctgcgcg agcacggcct gcggaacgtg acgacgaccg
     9361 tcctgccgtg gtacgaggtg ctcaccgggc agcagtggtg cgacctgctc agcaccgaga
     9421 gccggcacct ggccctgccg gaggggacga ggcggcggct gctgcgcgag gtcggccgat
     9481 tcctcgaccg caacggcggc cggatccggg tggactaccg gtgcaccctg gtgagcgcca
     9541 ccgccgaggg ctgaggctca cccggcggtc gccgggttcc gcgcgcccgg ctccgcggcc
     9601 agctgccgta cggccggggc caggtggttg acgaccgcca tcaccgccag gccggcggcg
     9661 atcgcgatca gcgggacgtc ggcgccgtac gcgtcggcga gcaccccgca gagcagcggg
     9721 gccggccagg cgaagcccat cgcggccagg ttcatcgacg tcagcacacg cgccgtcatc
     9781 gcgtccggca ccgtcgtcac cacccgcgtg gcgaacacca cgttcagcgg ggtgacgaac
     9841 gcgatgctca cgcccaggca cagcgcggcg agccagggcc ggtcggcgag cagcaccagg
     9901 ccgccgaccc cggccgcgac catccacgag acggccaaaa cgatccggtc gccgggcacg
     9961 cgccggacca cccactcggt ggcgagcgtg ccggccagcc cgcaccccgt ggcgatggcc
    10021 tcggcggcgc cgatcgtcga cggcgaggcg ccgttctcgc gcagcgcgac gacgaagagg
    10081 aatccgatcc cggcgaagag catgttcgtc agcgcggacc agagcagcgc gtaccgcagg
    10141 aaggggccgc gccggatgtg gctcagcccg gacatcaggt cgcggcggat cggcgtccgg
    10201 gcgggatcgg gcggttcgcc ggtgtccggc cccagcggtg tgcgcagcag gacggcggtc
    10261 agcgcgacgg ccacgaacga cagcgcgtcg gcgagaaacg gcgcccaccg ggccagcgtg
    10321 aacagcagcc cacccagcgg cgcgccggcc agctgggccc cgtagtcacg ggcctcggcc
    10381 cgggtgaacg ccgccttgag ctgctcggcc gcgacgatcc gtttcaccag cggcgacgct
    10441 gccgcgttga agaccgccga cgccaggccc tggatcagcg ccagagccgt gaccagcggc
    10501 aaccacaggc gtccggcggc ggcgatcgag cagagcgcgg ccgcgccggc cgcctggacc
    10561 agcgccgcgc cggccagcag ccggcgtcgc gggtaccggt cggcggccac gcccgcgggc
    10621 agcagaccgg ccagcaggcc gaccgccgcg cacgtgccga ccaggccggc cgctgcggcg
    10681 gagccggtga acgcgaggac cagcaacggc agcgccagcg cggagatgct ggagcccagc
    10741 cgggacagcg ccgtgccgga ccaccagagg ttgtagtcac ggttgcgcca caggggcgcg
    10801 gatttccggg gctgccgcgc ggtcggtcgc cgttgtccgt ggaccacgtc gtacacccta
    10861 tccgatgcaa cgatcagcat cgatgcctta ctcgcggcga atccgccgga gcgttgctcg
    10921 gccgtggtgt ccggggacga ccgcgtggcc acggccggtg gcgatcagcg gccgtgcggt
    10981 gggtcagtgg aagcgttcga cgaaggcgag cgcggtgtcg gcgacctcgc gccagccgct
    11041 gtcgatggtc agcgagtggc cccggttctc gatctcgacg atctcggtga cgccggggtt
    11101 gtcccgctgc tgccggtagg aggcgttggc gatcgaccac ggcacggtgt ggtcccgctc
    11161 ccccgagatg atcagcagcg ggccgcggtc cgggttgccg gtgtccaccc gggcctccga
    11221 ccacgggttg aagttcgcgg ccgcggcctg gaacagcggc tcgcccgagg ccggcaccgc
    11281 gtaggtggcg tacagttcgc gggcttcctc ctcggtgacg gcgttggcga agccgtaccg
    11341 gaactgctcg taggtcagcg gcacggcccg gtgatagttg gccgggttgc cgagcaccgc
    11401 gctcgccacc cgcagggcgg agatcggcag cggcagcacc ccgcggaacg gcgccgggtc
    11461 gatcgcgacg gacgccgcgg acaggccgcg cccggcgacg atctgggtga tcaggccgcc
    11521 gaacgagtga cccaccacgg ccggcttacg gtcgagccgg ccgatcagat cgcagaagtg
    11581 gtcggcgacc tggccgacgc tcttgcgggc gaacacctcc gggtgggcgt tggcctcctc
    11641 gaccgtctcc gggtcgtccg gccagccggc caccaccggc gcgtacccgg cggcggcgaa
    11701 cacctcggcc caccgctgcc agctcgacgg cagcaaccac agcccgtgga tgaacaccac
    11761 cggcggcttg ccgccggcgt tggccgcctc tacccggtcc agatcggtct gcagggacat
    11821 gctcacctct cgttgagaac ggcgcgcggg aacgcgatcg cctgggtgat ggcggcctcg
    11881 gcggcgcggg tctcgcgcac ggcgttgagc atcacgaggt cgtgga
//
