LOCUS       NZ_CP023865            24538 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4178710
            Orig. end                         :: 4203248
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24538
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24538
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24538
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14538](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14538)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(884..1345)
                     /locus_tag="ACTEI_RS18440"
     CDS             complement(884..1345)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012415.4"
                     /locus_tag="ACTEI_RS18440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CAP domain-containing protein"
                     /protein_id="WP_164466007.1"
                     /transl_table=11
                     /translation="MSPRHRKPTRTRRLVLATVTLGVLAHINQARAANGVPAFTLSAEL
                     STASYHAVMAGGRGLSHQCPGEAGLGERCTAAGVSWTAAGENIGRGNASGNAASILQAA
                     NGLTDLMLAEVPPNDGHRRNLLDPAFKRIGLAVTRGGDGRVWFTQDFVN"
     misc_feature    complement(1552..1567)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.01"
                     /tool="antismash"
     misc_feature    1561..1578
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.95"
                     /tool="antismash"
     gene            1705..4512
                     /locus_tag="ACTEI_RS18445"
                     /pseudo=""
     CDS             1705..4512
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019583.4"
                     /locus_tag="ACTEI_RS18445"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GH92 family glycosyl hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRPFVGTQNFGNTFPGASAPFGMVQVSPDTGGQGGYDHQQTSIYG
                     FSQTHLSGVGCGVAGELPIMPTTGAVDSGDPNVYRSAYSHSDEQASPGYYRVGLARYGV
                     QAELTATERTGWQRYTFPASGAANVLFNTGKANQDVFDSAVHVVGDRTVEGRVRAGHFC
                     AGKDDHTVYFSASFDRPFAAYGTWRGATLTPGARDAAGAGGNGAWVRFDTNADRDVVVK
                     VGLSYTGPDGARANLAAETGGSYDFDAVRDALRATWARQLDAVRITGGPAERQSAFYTA
                     LYHSLLHPNLAGDVDGRYTGFDDRVHTADGYTPYQNFSLWDTYRPQNQLLEMLTPQVAR
                     DVARSVLAIGRDGGWLPRWALANSETNIMTGDPVTPFLVEAWSKGLLAGYEQEAYTMLR
                     ANALGRPPAGSPYNGRSGNGHYSDRGYVPSGLSLGADCVHQGGDNDCAHPASATLEYAA
                     ADASLALMAAALGRADDARVLTERGQWYRNLWDTSIGQFRPRTTTGAWVTPYDPVEAGH
                     QFHEGGAHQYQWLVPQDPAGLVSLMGGRAAAEQRLDAFFAYPQLLTDPAGAARSAWIAG
                     PYDYYSKPTYNPNNEPDLLAPYVYHWAGAPAKTATVVRAAMTLFTTGPDGMTGNDDLGT
                     MSA"
     misc_feature    4539..4554
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            4689..7493
                     /locus_tag="ACTEI_RS18450"
     CDS             4689..7493
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014693699.1"
                     /locus_tag="ACTEI_RS18450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_203723638.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.8e-16, bitscore:
                     57.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILAVGATVVGLAAPGASAEAPADPATRAYEQIAALQQLKKSLT
                     PTERKLDSRLAVELRKRADRVPADALPHLTTGIEVSRSGTTEVEVHADKVGADLLARLR
                     AAGAGIRFPSPAAGTVLVEAPLTALPTIAGWKDVTGVNAKHGAITARQLDPRDPAAPES
                     KQERAARAERAAHAARAVPRAAAAAPAGQGSVVAEGDRTHAADTARTRHRVTGVGVKIC
                     ALSDGIDSLAASQATGDLPAEVDVLPGQEGSGDEGTAMLEILHDLAPNAELGFATAFTS
                     EASFAQNIRALRFTAHCDIIVDDVVYYHESPFQDGLPAQAVNAVTADGAFYFSSAGNEG
                     NVVDGTSGNWEGDFADSGRGVGKFAGIAHDFDPGPGVQVFNPLSRNSAGRVTTLWWADP
                     LGGSADDYDLYLTDAAGNVTDFSQDTQDGDDDPFEILATGSGANQRLAVVKYAGAARYL
                     QLSVFRGRFADSADGLKGFATPGVTRGHSAAERAFSVAAAPAKDPLPRDLEAGDPPNPA
                     GPYPNVFTRASQPERFTSDGPRRIFFAADGTPLTPGDFSATGGVVRAKPDITAADGVAT
                     SVPDFSPFYGTSAAAPHAAAIAALALSGNPGLSDAEIRAALTGTALDLTPSGYDTRTGH
                     GVIRADLLLRNTGATPQPLVRAGTPTVTPATGDGDAYLEPGEQATVALPARNVGDGTAT
                     GVNVVVDPDDPRVTVAPRAASYGTIAAGASKSKNYRLTLAAGYPLGRPVTLRVRTTFAG
                     VLSPTTSTVVVPTGQPSATVHDFAYTGPVVPIPDNDPAGATASVDVTGVGYASALTFSI
                     DGTACSTDTGAATVGIDHTFVGDAVGTLTAPDGRTATLFARDGGAGNNLCQVVFDDAAT
                     TPFAAVLSSNAPFTGAWKPDEPLSSLRVSPADGTWKFRVVDSANADTGSIRAFSLHLSG
                     FEPA"
     gene            complement(7739..8533)
                     /locus_tag="ACTEI_RS18455"
     CDS             complement(7739..8533)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="ACTEI_RS18455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_122978790.1"
                     /transl_table=11
                     /translation="MTARTAAAVPAGETVPAGSARATRIIAQRDLCRQVRHPGALAAQA
                     VQMLFFVLVYAVGFDGMIAPVDGVAFSAYVYPGIIAVQVVTAGIGSGLTYAWDRDHGVL
                     REMLVAPVPRICLPLGKVAATVTLVATQTAAMLAVAPLLGLRLSAASFAAGVGGYAAAA
                     AVFSVIGLLLATLIASARTLQATVQVGMYPLLFLSGSVFDPEQAPSWLAVAVAINPMTY
                     AVDLARHALLATPSGHPVWVDVLVLGGLLAGAGAALRARVGS"
     gene            complement(8530..9456)
                     /locus_tag="ACTEI_RS18460"
     CDS             complement(8530..9456)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="ACTEI_RS18460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_122978791.1"
                     /transl_table=11
                     /translation="MTTAAFDIDTLRVTYGEVVALDDISLRSAPGRITALLGPNGAGKS
                     SLLQALSTALVPAAGTIRIFGHDTRRQPALARRRLGLVFQERTLDEDLSVWQNLWFHAR
                     LFGLPRHDARQAVNRLLAQFELTHRAGDAVSALSGGLSRRVEIIRAMVHRPGLLILDEP
                     TTALDPQARRRVWDDLRRLRTEAGTAILYSTHHLDEAEYADDVVIVDGGTVVRRGSPDQ
                     LKAGLASSRVLLSTADDALALTSLAAAGFDAGPHSAGIAVHCAEPERRIAEVIAALTVP
                     VRSVSVRRPSLDDVFLALGAAGAEVRR"
     gene            complement(9453..10019)
                     /locus_tag="ACTEI_RS18465"
     CDS             complement(9453..10019)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="ACTEI_RS18465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavoprotein"
                     /protein_id="WP_122978792.1"
                     /sec_met_domain="Flavoprotein (E-value: 3.1e-23, bitscore:
                     80.8, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGAELMGAATLPQRLLIGVSGSVAALNLPAYLHALRVAGVQRLV
                     AVLTHTAERFTPPATLELICDAVCTESDHGRGHVALGRWAEQVVVLPATAHLLGCLAHG
                     LGPNLLATTLLATDAPITLVPAMNEVMWRRPAVRRNVDTLRGDGHRVIEPLPGATYEVA
                     SRSIVPGLTIPPPESLVQLLTGVHA"
     gene            complement(10001..11398)
                     /locus_tag="ACTEI_RS18470"
     CDS             complement(10001..11398)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="ACTEI_RS18470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_122978793.1"
                     /sec_met_domain="LANC_like (E-value: 8.4e-49, bitscore:
                     164.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTDLRDEPPVAVLAKAREAVTLVATRLADPDTVARIAGDDGNR
                     EPIVNAAPWEPLTLSTGLPGIVLFYAELARTDARWLSVAHRHMRRAARLMASSPSRGLH
                     AGPASLLTAAQSCAAATGEGRYARLRRDLAGWLATDQQRRLDDFAARSAPGVPWAAYDV
                     INGMSGTGRLLLDVVDDPAEDSAAARQALDRTLRHLVRLSEPITVDGTGVPGWWVPAGL
                     QPIEQDRQTYPRGDFNLGLAHGAAGPLALLSLAARRGHEVPGQHAAVARIADWLTGWAR
                     SDECGAYWPCRVSWDEQVAPDRPGTAFTRTAWCYGAPGVASALYLAGAVHAVDAWRQAA
                     VGALRAALTRPERRWHLDGPTVCHGLAGFVQVLWRVGTASGDRHLIAGAARVARRMLDF
                     LDPRAPFGFAHLVPDSPRGWQDATGHRALNVAGILEGAAGVACTLLPFLGDAPGTDRAW
                     DRCLALS"
     gene            complement(11395..14538)
                     /locus_tag="ACTEI_RS18475"
     CDS             complement(11395..14538)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="ACTEI_RS18475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_122978794.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-178, bitscore:
                     593.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.8e-13,
                     bitscore: 49.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.3e-34, bitscore:
                     117.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRALRAWNHFLVRAPLAATSAASRLTPDTDPADGRPAYLAVLR
                     AANRDARLVEALTLATPTLTAVLDRVAAGHGDAFKLTQLRRAALAVLRYDIRMRTRPTP
                     FGLFAGVTTGRFDTTATAEWRGGHRTRTHADMGWLLTLVRRLETDPVVLPGLPVQAHQA
                     LIRRGDRLVLNIPSTPDMLAGQPGRACVSIRNSAIVDAAVRGARRLIPFAELSTALGAQ
                     FPAAPAERIHALLMSLVEQEVLMTGLRPPLDGGDPLDHVIAVLQRAAPAAAAQLRAFDR
                     RRRAYDTIPVGAGRDALKELLGTAGRLQGHTHPLHIDLAVDADIRLPEAVRAEVESAAD
                     LLWRMSTPRLGMRALRAYHARFLERYGADRVVPLLELLDENRSLGAPAGYQWPVSEAPA
                     DPPDDPAPVTRSRRIAALAAEAIRQRRREIVLDRDSIGDLLYDRADTDDVPSSCELYVH
                     VVAASQDALAGADFRVVLSPNPGSHHAGATMGRFADLLPDGPQLFAEQRRRPQHVAGAI
                     TADLAFTARSSRAANLAHTAARTGRRISVGLPDAPGVQEIALDEIGIAANLERLCAIHL
                     PTGREISAQSPNMISPATQAPNPARLLHEIGLEGQRLWEPWNWGPMADAPYLPRIRYGR
                     TVLAAATWRVDALRGAAGDPARWVAAVEDWRGAWDVPRRILVVTADHRLVLDLADAWHV
                     ELLRDEVRRDAGVVVQEIAGEYEGWLDEGISGHTVEIVVPLSRRRTRPSRSGHVARLDP
                     GRTPAPATGEWLYFQVYGSRRTQDDLVREQLPALVQAAAEHGADRWFFLRYTDSQGHHL
                     RIRLHGMPSPRWAQAGAAVGDLLTRWQRAGIAGGHRLDQYDPELERYGGAPARDAAELV
                     FQHDSTAAIDLMRLARDPRCPYTLDELAVFSTAALAQAFGLPSPGEHRLPEQYADDAAA
                     VWLSATGSRRELPGSFRERAAWWRQRVDPATRFAALTGEPAGRLVRQALHQRDEAVRAF
                     AQRLHATAARTPQARVVGSLLHMTCNRLLGGNAAREREILGIARGAVQDNHARRRHTR"
     aSDomain        complement(13786..14049)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ACTEI_RS18475_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-15"
                     /identifier="RREFam001.1"
                     /label="ACTEI_RS18475"
                     /locus_tag="ACTEI_RS18475"
                     /protein_end="251"
                     /protein_start="163"
                     /score="49.1"
                     /tool="antismash"
                     /translation="LIRRGDRLVLNIPSTPDMLAGQPGRACVSIRNSAIVDAAVRGARR
                     LIPFAELSTALGAQFPAAPAERIHALLMSLVEQEVLMTGLRPP"
     gene            complement(14627..14806)
                     /locus_tag="ACTEI_RS18480"
     CDS             complement(14627..14806)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS18480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_122978795.1"
                     /transl_table=11
                     /translation="MPIDLFTQLPPADETIDDVFDLDVEVTVETTTSAIYHSGLICTPT
                     CISPNGGSFCSFCC"
     CDS_motif       complement(14702..14806)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPIDLFTQLPPADETIDDVFDLDVEVTVETTTSAI"
                     /locus_tag="ACTEI_RS18480_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14627..14701)
                     /prepeptide="core"
                     /locus_tag="ACTEI_RS18480_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.80"
                     /molecular_weight="2343.7"
                     /monoisotopic_mass="2342.0"
                     /core_sequence="YHSGLICTPTCISPNGGSFCSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPIDLFTQLPPADETIDDVFDLDVEVTVETTTSAI"
                     /leader_location="[14701:14806](-)"
                     /alternative_weights="2361.8"
     misc_feature    complement(14885..14902)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            complement(14916..15470)
                     /locus_tag="ACTEI_RS18485"
     CDS             complement(14916..15470)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1126:
                     extracytoplasmic-function sigma-70 factor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019265.4"
                     /locus_tag="ACTEI_RS18485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_122978796.1"
                     /transl_table=11
                     /translation="MPRLTTADHTPVPSGPPVRSGQHRWDLLAPHHGRLVRIARRRLPN
                     PHDAEDCAQEALIRAACATTLPTEHVGRILTTIVIRLCIDHCRARTTGDRVLARIGAAE
                     QHLPSFEEAVCDRAEAVWIRERLDGLLTGRQLAVLQARADGLSTRQAAGRLNITHKSAE
                     AALTAARARVRRLVSAAAENL"
     gene            16196..20068
                     /locus_tag="ACTEI_RS18495"
     CDS             16196..20068
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="ACTEI_RS18495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_145831035.1"
                     /transl_table=11
                     /translation="MDADHPAEDRGSPDPVSAFASRLRRLQADSGGPSVRDLERLTAKV
                     AMPYTRTTIQDKLTGRSAVSWEFVEAFVRACALHTGTRAEVDLRPWRAWHAEMTRDLTA
                     QRAGRRRSVKADVCPYRGLEVFCAEHAEWFHGRTAAVQHVLAALAGHQQGVLLLGPSGA
                     GKSSLIQAGVVPALGAGRLPGSDRWLIVVARPGKDLLGEMARAGLPEVRDEPIAAAVAS
                     RLADQPDTARLLLIIDQFEELLTPPRSAAETDWDGHHAGRRDDAQRQGIEQLTAAIGTP
                     GLSVVLVVRDDFYPRLASQAPALLDRLTAGLINVPALLSAHDLQDIITKPAQAVGLAYQ
                     DGLPERIVSDVLAANPDAAPALHAPVTVLPLLELALQQLWQRRQGSTLTHEAYQRLGGL
                     TGAVATWCGAAVAQLPAVQRSVAQQILIALVRPADETHHIPAMRQQAPLAALRELARPI
                     GAGGGESAPEMVDEVLAVLTGQRIVTTRIVGAAQPDQQPGVDGVVPVAELVHDAVIRDW
                     TTLRHWVAQDQRFQDWLRRAEERHVRWSDHHDPDDLLHGSDLAEGVSWSAHRPLPHDIA
                     AFLQTSRRHQQARIRRARRLNAVLAGLLAIALMAAGVATWQRRTAVAAQQVALSRQLAA
                     QSAVLLPTNSELADLLAVQAYRISPTEEAVASLYSAVSQPVVRALTGHTDTVSEVTYSP
                     DRRHLATAGHDRTVRVWDLDTGGSRTLSGHSDAVSAVSYRPDGRQLASAGRDRSVRIWE
                     LDTGASRALTGHTGEVSAVAYHPDGRQVASAGRDKTVRLWDLGTGTSRTLTGHTDGVSA
                     VAYSPDGRHLATAGHDRTVRLWDLGTGKPRTLTGHTGAVSAVAYHPDGRHLATAGHDRT
                     VRLWDLGTGKPRTLTGHTDAILTVAYSPDGRHLASAGRDRTVRAWNVDAGTSRALTGHT
                     NWVFTVAYSPDGRQVASAGGDETVRLWDLDTTQSRTLSGHTDAASAVAYSADGRHLASA
                     GRDRTVRAWDLDTGTSRTLTGHTDAVFAVAYRPDGHQLASTGRDGTVRVWDLDTGATRT
                     LTGHTGAAYTVVYSPDGRQVATAGRDRTVRLWDLDTGTSRALTGHTDRASAAAYRPDGH
                     QLASGGRDRTVRLWDLDTGTTRTLTGHTDGVSAVTYRPDGHQLASAGRDKTVRLWDLDT
                     GTTRTLTGHTAEVFTVAYSPDRRHLATAGRDKTVRVWDLETGAYRTLTGHTDAVAEVTY
                     SPDGHHLASASWDGTVRVWANVGLTLTAAIDLICRNLGRDLTPAERGTYLPSAGSAPPA
                     CPAPDG"
     gene            complement(20094..20906)
                     /locus_tag="ACTEI_RS18500"
     CDS             complement(20094..20906)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="ACTEI_RS18500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_164466008.1"
                     /transl_table=11
                     /translation="MLGRQLRILREECGISREDAAKHLRCHPAKVSRLELGQVPFKDAD
                     LDTLLTYYRMHDARERAALLSLNARLNEKPWWAPYSNSLAEWYRSYLLLESVAQYIYTY
                     ENRFIPGLLQTREYAEATIRDRYTDEEDIQRRVDVRMRRQASILRRRASQIWAIIDNAA
                     LEDGLDDPAVMRRQLDFLIRATDLPHVRIQIVKRGACAARSNSFSILRLRSARLSEVVY
                     LEQLDDALFIEDVAKSEPYRIAWSEIGIVACKPEDTRRILEQTLRRCG"
     gene            complement(21052..21204)
                     /locus_tag="ACTEI_RS37095"
     CDS             complement(21052..21204)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS37095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164466009.1"
                     /transl_table=11
                     /translation="MLTVAVLLMGFSLAAAVFGQPHLATIAGTACVALSSRLAHRLLPG
                     RSARR"
     misc_feature    21297..21317
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(21343..21356)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.34"
                     /tool="antismash"
     misc_feature    complement(21825..21842)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            21876..22769
                     /locus_tag="ACTEI_RS18505"
     CDS             21876..22769
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018794794.1"
                     /locus_tag="ACTEI_RS18505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_122975831.1"
                     /transl_table=11
                     /translation="MPRVAAARRHDLTDVQWAVLEPALPAEPRRGRPPRWTKRQIIDGI
                     RWRVRAGTPWRDVPEVYAPWQTLYRWFRRWQRDGTWAKILARLQTRADAAGDIEWAVSV
                     DSTISRAHQHAAGARRDGDLQKEPPGGVFAEPGDHALGRSRGGFTTKTHLACEQGRKTL
                     STVITAGQRGDSPQFIKVLERIKVYRVGGGRPRTRPDLVLADKAYTSRGNRGYARRRRI
                     RVCIPSKADQDAYRKAKGSKGGRPPAFDPVVYRQRHAVECGINQLKQNRAMATRYDKLA
                     VRFEATVTIAVINQWL"
     gene            complement(22790..23224)
                     /locus_tag="ACTEI_RS18510"
     CDS             complement(22790..23224)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020509467.1"
                     /locus_tag="ACTEI_RS18510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6069 family protein"
                     /protein_id="WP_122978800.1"
                     /transl_table=11
                     /translation="MTNDKHLAEPTSTHPTIRRRAGRALTVAAAAAGALLIWAVNGPLA
                     GADPTVRRGGGVEQIGPAAVVPAALAAGLVAWGLLALLERHTRRPARTFRMIGLLVLLL
                     SLAGPLGSGVDAGSRLALVGMHLTVGAALLIGLPRGCPRR"
     gene            23926..>24039
                     /locus_tag="ACTEI_RS38410"
                     /pseudo=""
     CDS             23926..>24039
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="ACTEI_RS38410"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHDVLAHRLSLLATFAGAMEYRPDSSPEQMSRAAGVVR"
ORIGIN
        1 gtgggtggcg gtggtcctgc tggcggcggc ggccgccgtg ctcgccctgc gcgacccggc
       61 cggcccggcg gcgccggcga ccggcccggc cgcgccggcc gacctgcagg ggcagatcac
      121 cgcccggatg cgcaccgcgc tcgaacagtc cgaccccgag cagcatcagc acgccggaca
      181 ccaggcccaa ccggcgaccg gcgcggacgc ggcgagaccg gaggtgatct gcggggtccg
      241 cgtctacggc tatgagccgg ccggcgccac cgcgctcacc gaggtgcgga ccgtctacgg
      301 cttccacctc tgcggcgtcg ccgagcgcaa gcgcccctgg gacgtggccg acaagctggc
      361 cggaccggtg atcctggaca tgtccaccga cccgcccggc atccgggtcg tcgaggcgac
      421 cgccgaggtg cgcttcgtcg accggctgca ccagatgttc ccggaccggt acgcgcagct
      481 ggccatgcgg gaggcgctca ccgagtcgga gatgaccgac ctgcgccgcc ggtacgactc
      541 cgcggcccag gtctgaccgc accgccccgg gacatcagcc ggccgcccgg cgccggcgag
      601 cagccgacca tgccgtaccg ggcgcgggcc ggatcgaagc gccggcggcc ggatcgaagc
      661 gcccgcgacc gggtcgtcgc ggcggatcag ccagtcgccg gggccgggac gcggtggggc
      721 cagcgccgcg caggggcgtg cggtggccgg ccgacgcccg acctcgtcga ccgggatgtc
      781 acggcggcgc gccacctcgc ggagaagtgc cgtcgatgtc atcgtggcgg tatgccgggg
      841 cgcgccgccg tccaccgtgg acggccggca accggcccgg cggtcagttg acgaagtcct
      901 gggtgaacca gacgcggccg tcgccgccgc gggtcacggc cagcccgatc cgcttgaagg
      961 ccgggtcgag caggttgcgg cggtggccgt cgttcggcgg cacctcggcc agcatgaggt
     1021 cggtcagccc gttcgcggcc tggaggatcg aggcggcgtt gccgctcgcg ttgccccggc
     1081 cgatgttctc gccggccgcg gtccaggaga ccccggccgc ggtgcaccgc tcgccgaggc
     1141 cggcctcgcc ggggcactgg tgcgacaggc cgcgaccacc ggccatcacg gcgtggtacg
     1201 acgccgtcga cagctcggcg ctgagggtga acgccgggac gccgttcgcc gctcgcgcct
     1261 ggttgatgtg ggcgagcacc cccagggtga cggtggccag cacgagacga cgggtccggg
     1321 tgggcttgcg gtggcgtggg gacacggcgg tcctcaacga tcggcagggc gccggtcacg
     1381 gcgcacggcc gactctgcgg gaccgccgcc ccggcggcaa gtcgctgagc aacatctaat
     1441 gatcggctca tcggcggcaa cgatcggccg ctgccaccgg gtccgagccg ccccgccggg
     1501 cgcgcggccg cgcaccggtc cgaccacagg cattgacgat tctcagtgtt tgtgacaacg
     1561 atgtcaggac cgtgttccgc tgtcgacccg gaggtacccg tggcgtcgcg actctcccgg
     1621 ctggccgccg ccgcgtggct gacgaccgcc gccaccctgg tcaccggcgg cgccgctgaa
     1681 gccgccgcga cgccggtcga cctggtgcgg ccgttcgtcg gcacgcagaa cttcggcaac
     1741 acctttcccg gcgccagcgc gcccttcggc atggtccagg tcagcccgga caccggcggg
     1801 cagggcggct acgaccacca gcagacgagc atctacggct tcagccagac ccacctgtcc
     1861 ggggtcggct gcggcgtcgc cggcgagctg ccgatcatgc ccaccaccgg cgcggtcgac
     1921 agcggcgacc cgaacgtcta ccgctccgcg tacagccact ccgacgagca ggcgtccccg
     1981 ggctactacc gggtcggcct ggcccggtac ggcgtgcagg ccgagctgac cgccaccgag
     2041 cgcaccggct ggcagcggta caccttcccg gcctccggcg cggcgaacgt gctgttcaac
     2101 acgggcaagg ccaatcagga cgtcttcgac tccgcagtgc acgtggtcgg cgaccgcacc
     2161 gtcgagggcc gggtgcgcgc cgggcacttc tgcgccggca aggacgacca cacggtgtac
     2221 ttctcggcca gcttcgaccg gcccttcgcc gcctacggca cctggcgggg cgccaccctc
     2281 accccgggcg cccgggacgc ggccggcgcc ggcgggaacg gggcctgggt ccgtttcgac
     2341 acgaacgccg accgggatgt cgtggtcaag gtcgggctgt cgtacaccgg gccggacggg
     2401 gcgcgcgcga atctggccgc cgagaccggc ggctcgtacg acttcgacgc cgtccgggac
     2461 gccctgcgcg ccacctgggc ccggcaactc gacgccgtgc ggatcaccgg cgggccggcc
     2521 gagcggcaga gcgccttcta caccgcgctc taccactcac tgctgcaccc gaatctcgcc
     2581 ggcgacgtcg acggccgcta caccggcttc gacgaccgcg tccacaccgc ggacggctac
     2641 acgccgtacc agaacttctc gctctgggac acctaccgcc cgcagaacca gctgctggag
     2701 atgctgacgc cgcaggtcgc ccgggacgtc gcgcggtccg tgctggccat cgggcgcgac
     2761 ggcgggtggc tgccgcgctg ggcgctggcc aacagcgaga ccaacatcat gaccggtgac
     2821 ccggtcaccc cgttcctggt cgaggcgtgg tccaaggggc tgctggccgg gtacgagcag
     2881 gaggcgtaca cgatgctgcg ggccaacgcg ctgggtcgtc cgccggccgg ctcgccgtac
     2941 aacgggcgca gcggcaacgg ccactacagc gaccgcggct acgtcccgtc cgggctgagc
     3001 ctcggcgccg actgcgtcca ccagggcggc gacaacgact gcgcgcaccc ggcgtcggcc
     3061 accctcgaat acgccgcggc ggacgcgtcg ctggccctga tggccgccgc gctgggccgc
     3121 gccgacgacg cgcgggtcct caccgagcgc ggccagtggt accgcaacct gtgggacacc
     3181 tcgatcgggc agttccggcc gcggaccacc acgggcgcct gggtcacccc gtacgacccg
     3241 gtcgaggccg gccaccagtt ccacgagggc ggcgcccacc agtaccagtg gctggtgccg
     3301 caggacccgg ccgggctggt gtcgctgatg ggcgggcgcg ccgccgccga gcagcggctg
     3361 gacgcgttct tcgcctatcc gcagctgctg accgacccgg ccggcgccgc gcgctcggcc
     3421 tggatcgccg gcccgtacga ctactacagc aagccgacct acaacccgaa caacgagccg
     3481 gacctgctgg ccccgtacgt ctaccactgg gccggcgccc cggcgaagac cgccaccgtg
     3541 gtgcgggccg cgatgaccct gttcaccacc gggcccgacg gcatgaccgg caacgacgat
     3601 ctgggcacca tgagcgccta gtacgtgttc tcctcgctcg ggctctaccc caccatgagc
     3661 ggcgccggct tcctcgccgt cagcagcccg cagttccccg cggccacggt ccgcatcggc
     3721 gcctgggcgg accggcaggg cggcaccctg acgatcaccg caccggacgt cagcgacacc
     3781 cgccggtacg tgcagtccgt gcgggtcgac ggccgcgcgc atgcgccgaa ctggctcacc
     3841 tggcaggcga tcgcccgggg cggcagcatc gcccacaccg tcgggacgtc cccgtcggcc
     3901 tggggcaccg cggtgaccga cgagccgccc tcggtgaacg ccacgccgtc gcaccactgc
     3961 gcggtgaccg ccggcgcgca gtgcgcggtc gacctgtccg cggcccgcgc cacggacggc
     4021 accgccacca cggcggccac ccgggagggc gacttcgacg gcgccggctg gagctacgac
     4081 gcggcgctgc tgcccccggc cggcacggtg acctggaacg gcgtgaccta cagcgcgcca
     4141 tcgccggcgg gcgccgccgg caacttcgtg ccggccggcg ggccggcgct gccgctgccc
     4201 acgctgcggc gcggcacgct gcggctggtc gccgccgcgc accacggccc ggtgaccggc
     4261 acggtcacgg tgcgctatac cgacggcggc acggccgcga cgacgctcac cgtcccggac
     4321 tggtgcgcgc cggccggatc cggtacggcg gtgctcgcca tgccgcaccg gatccgggcc
     4381 ggccagggcg tggacggtcc accggccagc ctgttcggct tcaccgtcgc gctcgacccc
     4441 ggccgggagc tgcgctcggt caccctgccc gcggacgcac ggatccgggt gtacgccatc
     4501 accgtccact gagcaccgcg gcggcccggc cgtccgcgct tcccacttgc aaaccctgcg
     4561 tgtcgatcga gttacagggt gtcgtggttc gaccccgcac cggctagcat ccacagacat
     4621 cgaatcgatc tctgtcagtg gggggctgga ctttgcacgt ggacagcaga cgtatgctcc
     4681 gacgctcggt gacgatcctc gcggtcggcg ccaccgtcgt gggcctcgca gcgccgggcg
     4741 ccagcgccga ggcgccggcc gacccggcca ccagggcgta cgaacagatc gccgcactcc
     4801 agcagttgaa gaaatccctg accccgaccg aacgcaagct cgacagccgg ctggcggtcg
     4861 agctgcgcaa gcgcgccgac cgggtgccgg cggacgcgct gccgcacctg accaccggca
     4921 tcgaggtgtc ccggtccggc accaccgagg tcgaggtgca cgccgacaag gtcggcgccg
     4981 acctgctcgc ccggctgcgc gcggccgggg cgggaatccg cttcccgtcc ccggccgccg
     5041 ggaccgtcct ggtcgaggcg ccgctcaccg cgctgccgac gatcgccggc tggaaggacg
     5101 tgaccggcgt caacgccaag cacggcgcga tcaccgcccg gcagctcgac ccgcgcgacc
     5161 cggcggcgcc ggagtccaag caggagcggg ccgcccgggc cgagcgcgcg gcccacgcgg
     5221 cgcgggccgt gcccagggcc gccgcggccg cgccggccgg ccaggggtcg gtggtcgccg
     5281 agggtgaccg gacccacgcc gccgacaccg cccgcacccg gcaccgggtg accggcgtgg
     5341 gcgtcaagat ctgcgccctc tccgacggca tcgactcgct cgccgcgtcg caggccaccg
     5401 gtgacctgcc ggccgaggtg gacgtgctgc ccggccagga gggctcgggc gacgagggca
     5461 ccgcgatgct ggagatcctg cacgatctcg cgccgaacgc ggagctcggc ttcgcgaccg
     5521 cgttcaccag cgaggccagc ttcgcccaga acatccgggc gctgcggttc accgcgcact
     5581 gcgacatcat cgtcgacgac gtcgtctact accacgagag ccccttccag gacgggctgc
     5641 cggcgcaggc ggtcaacgcc gtcaccgccg acggcgcgtt ctacttcagc tcggccggca
     5701 acgagggcaa cgtcgtcgac ggcacctccg gcaactggga gggcgacttc gccgactccg
     5761 gtcgcggggt cggcaagttc gccggcatcg cgcacgactt cgacccggga ccgggcgtgc
     5821 aggtgttcaa cccgctgtcg cgcaacagcg ccggccgggt gaccacgctg tggtgggcgg
     5881 acccgctggg cggctcggcc gacgactacg acctgtacct gaccgacgcg gccggcaacg
     5941 tgaccgactt ctcccaggac acccaggacg gcgacgacga cccgttcgag atcctggcca
     6001 ccggctccgg cgccaaccag cggctcgccg tggtcaagta cgcgggcgcg gcccgctacc
     6061 tgcagctgtc ggtcttccgc ggccggttcg ccgactcggc ggacgggctc aagggtttcg
     6121 ccacgcccgg cgtgacccgc gggcacagcg ccgccgaacg cgcgttctcg gtggccgcgg
     6181 cgccggcgaa ggacccgctg ccccgggacc tcgaggccgg cgacccgccg aatcccgccg
     6241 gaccctaccc gaacgtgttc acccgggcgt cccagccgga acggttcacc tcggacggcc
     6301 cgcgccggat cttcttcgcc gccgacggca cgccgctcac ccccggcgac ttcagtgcga
     6361 ccggcggggt cgtccgggcg aagccggaca tcaccgccgc ggacggtgtc gccacctcgg
     6421 tcccggactt ctcgcccttc tacggcacct cggcggccgc gccgcacgcc gccgcgatcg
     6481 cggcgctggc gctgtcgggc aaccccgggc tgagcgacgc cgagatccgc gccgcgctga
     6541 ccggcaccgc cctcgacctg accccgagcg ggtacgacac ccgcaccggc cacggcgtga
     6601 tccgcgccga cctgctgctg cgcaacaccg gcgcgacacc gcagccgctg gtgcgcgccg
     6661 gcacgccgac ggtcaccccg gccaccggcg acggggacgc ctacctggag ccgggcgagc
     6721 aggccacggt ggcgctaccg gcgcgcaacg tcggcgacgg caccgcgacc ggcgtcaacg
     6781 tggtggtgga cccggacgat ccgcgggtca ccgtggcccc gcgtgccgcg tcctacggca
     6841 ccatcgccgc gggcgcgtcg aagtcgaaga actaccgcct gaccctggcc gccggctacc
     6901 cgctgggccg gccggtcacg ctgcgggtcc ggaccacgtt cgccggtgtc ctgtcgccga
     6961 ccaccagcac cgtggtggtc ccgaccggcc agccgtcggc gacggtgcac gacttcgcct
     7021 acaccggccc ggtggtgccg atcccggaca acgacccggc cggcgccacc gccagcgtgg
     7081 acgtcaccgg cgtcggctac gcctcggcgc tgaccttctc gatcgacggc acggcctgct
     7141 ccaccgacac gggtgcggcg acggtgggca tcgaccacac cttcgtcggc gacgccgtcg
     7201 gcacgctgac cgcgcccgac ggccgcaccg ccacgctgtt cgcccgcgac ggcggcgccg
     7261 gcaacaacct ctgccaggtg gtgttcgacg acgccgcgac gaccccgttc gccgcggtgc
     7321 tgtccagcaa cgcgccgttc accggcgcct ggaagccgga cgagccgctg tcgtcgctgc
     7381 gggtctcccc cgcggacggc acgtggaagt tccgggtcgt ggacagcgcg aacgccgaca
     7441 ccggctcgat ccgggcgttc tcgctgcacc tgtccggctt cgagccggcc tgaccggcgc
     7501 ggccgtccgg gcgccctgcg cgatcgcgcc cggacggccg cccgccccac cgcggccagg
     7561 tctacgccgg ccacccccag ccgatccacc tgttcgtcga gatcacatgc aacgcgtacg
     7621 tggccggcga gggcgaccgg gagaaggcca tccggggcgg cgtcgacccg gtcggcaccg
     7681 gccgcctcac cctgccgcac gaccggctcg ctccggaccg gtgcgtcgcg gcaggccgtc
     7741 agctcccgac ccgggcgcgc agggcggcgc cggcgcccgc cagcagcccg cccaggacga
     7801 gaacgtccac ccacaccgga tgcccggacg gcgtggccag cagcgcgtga cgggccaggt
     7861 ccacggcgta cgtcatgggg ttgatcgcca ccgcgaccgc cagccaggag ggcgcctgct
     7921 cggggtcgaa caccgagccg gacaggaaca gcagggggta catacccacc tggaccgtgg
     7981 cctgcagggt ccgcgccgag gcgatgagcg tggccagcag caggccgatc acactgaaca
     8041 ccgcggcggc cgccgcgtac ccgccgaccc ccgcggcgaa cgacgccgcg ctcaggcgca
     8101 ggccgagcag cggcgcgacg gccagcatcg ccgcggtctg cgtggccacc agcgtcaccg
     8161 tggcggcgac cttgcccagg ggcaggcaga tccggggtac gggcgcgacc agcatctccc
     8221 gcagcacccc gtggtcgcgg tcccaggcgt aggtgagccc ggagccgatc ccggcggtca
     8281 ccacctgcac ggcgatgatc ccggggtaga cgtaggcgct gaacgcgacc ccgtcgaccg
     8341 gcgcgatcat gccgtcgaag ccgaccgcgt agaccaggac gaagaacagc atctgtacgg
     8401 cctgggcggc cagcgctccc gggtggcgga cctgccggca caggtcgcgc tgggcgatga
     8461 tccgggtcgc tcgggcgctg ccggccggca cggtctcgcc ggcgggtacg gccgctgccg
     8521 tcctggccgt catcgtcgta cttccgcgcc cgcggcgccc agcgcgagga acacgtcgtc
     8581 caacgaggga cgccgcaccg acaccgaccg caccgggacg gtgagcgcgg cgatcacctc
     8641 ggcgatccgg cgctccggct ccgcgcagtg caccgcgatc ccggcggagt gcggcccggc
     8701 atcgaaaccg gcggcggcca ggctggtcag cgccagcgcg tcgtccgcgg tggacagcag
     8761 cacccgggac gaggcgagcc cggccttcag ctgatccggc gagccgcgcc ggaccaccgt
     8821 gccgccgtcg acgatcacca cgtcgtcggc gtactcggcc tcgtcgaggt ggtgcgtcga
     8881 gtacaggatg gcggtgcccg cctcggtacg cagccgccgc aggtcgtccc agacccgacg
     8941 ccgcgcctgc gggtcgagcg cggttgtcgg ctcgtccagg atcagcaggc cgggccggtg
     9001 caccatggcc cggatgatct ccacccggcg ggacaacccg ccggagaggg cgctgaccgc
     9061 gtcgccggcg cggtgcgtga gctcgaactg cgccagcagc cggttgacgg cctgccgggc
     9121 gtcgtgccgg ggcaggccga acagccgggc gtggaaccac aggttctgcc acacgctcag
     9181 gtcctcgtcc agggtgcgtt cctggaagac caggccgagc cggcgccggg cgagggccgg
     9241 ttgccgtcgc gtgtcgtgac cgaagatccg gatggtgccg gcggccggga ccagcgccgt
     9301 ggacagtgcc tgcagcaggc tggacttgcc ggccccgttc ggcccgagca gcgcggtgat
     9361 gcgcccgggc gccgagcgca ggctgatgtc gtcgagggcc accacctcgc cgtaggtgac
     9421 gcgcagggtg tcgatgtcga aggcggcggt cgtcacgcgt gcacccccgt tagcagctgg
     9481 accagcgatt ccggaggcgg gatggtcagc ccgggcacga tggagcggct cgccacctcg
     9541 tacgtcgcgc cgggcagggg ctcgatgacc cggtggccgt cgccgcgcag cgtgtcgacg
     9601 ttgcggcgta ccgccgggcg ccgccacatc acctcgttca tcgccggcac cagggtgatc
     9661 ggggcgtcgg tggccagcag ggtggtggcc agcaggttcg ggcccagccc gtgggccagg
     9721 cagcccagca ggtgggcggt ggcgggcagc accacgacct gttcggccca ccggcccagg
     9781 gcgacgtgcc cgcggccgtg gtcggactcg gtgcagaccg cgtcacagat cagttccagg
     9841 gtggccgggg gcgtgaacct ctccgcggtg tgggtcagca ccgcgaccag ccgctggacc
     9901 ccggcgacgc gcagggcgtg caggtaggcc ggcaggttca gcgcggccac cgatccgctg
     9961 accccgatga gcagccgctg cggcagcgtg gcggcgccca tcagctcagc gccaggcatc
    10021 ggtcccaggc ccggtcggtg cccggcgcgt cgcccaggaa cggcagcagg gtgcaggcca
    10081 ccccggcggc gccctcaagg atgccggcca cgttcagcgc tcggtggccg gtggcgtcct
    10141 gccagccgcg tggcgagtcg ggcaccaggt gcgcgaagcc gaagggcgct cgcgggtcca
    10201 ggaagtccag catccggcgg gcgacgcggg cggcgccggc gatgaggtgc cggtcgcccg
    10261 aggccgtgcc gacacgccac aggacctgca cgaagccggc caggccatga cacaccgtag
    10321 gaccgtcgag gtgccaccgc cgctcgggcc gggtcagcgc cgcgcgcagc gcgccgacgg
    10381 cggcctgccg ccaggcgtcg acggcgtgga cggcgccggc caggtacagc gcgctggcga
    10441 cgccgggggc gccgtagcac caggcggtcc gggtgaacgc cgtgccggga cggtcgggcg
    10501 cgacctgctc gtcccaggag acccggcagg gccagtaggc gccgcactcg tcggaccgcg
    10561 cccagccggt gagccagtcg gcgatgcggg cgacggccgc gtgctgcccg gggacctcgt
    10621 ggccgcggcg ggcggcgagc gacagcagtg ccagcggccc ggcggcgccg tgcgccagcc
    10681 ccaggttgaa gtcgccgcgc ggataggtct gccggtcctg ctcgatcggt tgcaggccgg
    10741 cggggaccca ccagccgggt acgccggtgc cgtcgaccgt gatcggctcg ctgagccgga
    10801 ccaggtggcg cagcgtacgg tccagggcct gccgcgccgc ggcggagtcc tcagccgggt
    10861 cgtccaccac gtccagcagc aggcggccgg tgccggacat cccgttgatc acgtcgtagg
    10921 cggcccacgg cactcccggc gcgctgcggg ccgcgaagtc gtcgaggcgg cgctgctggt
    10981 cggtggccag ccacccggcc aggtcacggc gcagcctcgc gtaccggccc tcgccggtgg
    11041 cggcggcgca gctctgtgcg gcggtcagca gcgaggcggg cccggcgtgc aggccccggg
    11101 acggtgacga cgccatcagc cgcgccgccc gccgcatgtg ccggtgtgcc acggacagcc
    11161 agcgcgcgtc ggtgcgggcc agttcggcgt agaacaggac gatcccgggc aggccggtgg
    11221 acagcgtcag cggctcccac ggcgcggcgt tgacgatcgg ttcgcggttg ccgtcgtcgc
    11281 cggcgatccg ggccacggtg tccgggtcgg ccagccgggt ggccaccagt gtcactgcct
    11341 cacgggcctt cgccagcacg gccaccggcg gctcgtcgcg aaggtcggtc acggtcatcg
    11401 ggtgtgcctc ctacgggcgt ggttgtcctg gacggctcct cgggcgatgc cgaggatctc
    11461 ccgctcgcgt gccgcgttgc cgccgagcag ccggttgcag gtcatgtgca gcaggctgcc
    11521 gacgacgcgg gcctgcgggg tgcgcgccgc ggtggcgtgc agccgctgcg cgaaggcccg
    11581 gaccgcctcg tcacgctggt gcagcgcctg ccggacgagg cgcccggccg gctcaccggt
    11641 cagcgcggcg aatcgcgtcg ccgggtcgac ccgctgacgc caccaggcgg cccgttcccg
    11701 gaaggacccg ggcagctcgc gccgggaccc ggtggccgac agccacacgg cggccgcgtc
    11761 gtcggcgtac tgctcgggca gccggtgctc gccgggtgac ggcaggccga acgcctgcgc
    11821 cagcgcggcg gtggagaaca ccgccagctc gtccagggtg tacgggcacc gcgggtccct
    11881 ggccagccgc atcaggtcga tcgccgcggt gctgtcgtgc tggaagacca gctcggcggc
    11941 gtcccgggcc ggcgcgccgc cgtagcgttc cagttccggg tcgtactggt ccaggcggtg
    12001 cccgccggcg atcccggcgc gctgccaccg cgtcagcagg tccccgacgg cggcgccggc
    12061 ctgcgcccac cgcggtgagg gcatgccgtg cagccggatc cgcaggtgat ggccctggct
    12121 gtcggtgtag cggagaaaga accaccggtc cgcgccgtgc tcggcggcgg cctgcaccag
    12181 cgccggcaac tgctcgcgta ccaggtcgtc ctgggtacgg cgggacccgt acacctggaa
    12241 gtagagccac tcaccggtgg ccggcgcggg ggtgcggccc gggtcgaggc gggccacgtg
    12301 gccggagcgg gacggccggg tgcggcggcg tgacagcggc acgacgatct cgacggtgtg
    12361 cccgctgatg ccctcgtcga gccagccctc gtactccccg gcgatctcct ggaccaccac
    12421 gccggcgtcc ctgcggacct cgtcgcgcag cagttcgacg tgccaggcat cggccaggtc
    12481 gagcacgagc cggtggtcgg cggtgaccac caggatgcgt cggggcacgt cccaggcgcc
    12541 gcgccagtcc tcgacggccg cgacccagcg ggccgggtcg ccggccgcgc cgcgcagcgc
    12601 gtcgacgcgc caggtggcgg cagcgagcac cgtacgcccg taacggatcc ggggcaggta
    12661 cggcgcgtcg gccatcgggc cccagttcca cggctcccac agccgctgcc cctccaggcc
    12721 gatctcgtgg agcagccggg cggggttggg cgcctgcgtc gccgggctga tcatgttcgg
    12781 tgactgcgcg ctgatctccc ggccggtcgg caggtggatc gcgcacaggc gctccaggtt
    12841 cgcggcgatg ccgatctcgt cgagcgcgat ctcctgcacc ccgggcgcgt cggggagccc
    12901 gacactgatc cgccggccgg tgcgcgccgc ggtgtgtgcc aggttcgccg cgcggctcga
    12961 ccgggcggtg aacgccaggt cggcggtgat cgcaccggcg acgtgctgcg gccgtcgccg
    13021 ctgttcggcg aacagctgcg gaccgtccgg aagcaggtcc gcgaaccggc ccatggtggc
    13081 cccggcgtgg tgcgagccgg ggttgggcga cagtacgacg cggaagtccg caccggccag
    13141 cgcgtcctgc gaggcggcca ccacgtgcac gtacagttcg caggagctgg gcacgtcgtc
    13201 cgtgtcggcc cggtcgtaca gcaggtcgcc gatgctgtcc cggtcgagca cgatctcgcg
    13261 gcggcgctgc cggatcgcct cggcggccag cgcggcgatg cgccggctgc gggtgaccgg
    13321 ggccgggtcg tccggcggat ccgccggggc ctcgctgacc ggccactggt atcccgccgg
    13381 ggcgcccagc gaccggttct cgtccagcag ctccagcagc ggcaccaccc ggtcggcgcc
    13441 gtaccgctcc aggaaacgcg cgtggtacgc ccgcagcgcg cgcatcccga gccgcggcgt
    13501 ggacatgcgc cacagcaggt cggcggcgga ttccacctcg gcgcgcaccg cctcgggcag
    13561 gcggatgtcc gcgtcgacgg ccaggtcgat gtgcagcggg tgggtgtgcc cctgcaggcg
    13621 cccggcggtg ccgagcagct ccttgagcgc gtcccggccg gcgccgacgg gaatcgtgtc
    13681 gtaggcgcgg cggcgccggt cgaaagcacg cagctgggcg gcagcggccg gggcggcccg
    13741 ctgcagcacc gcgatgacgt ggtccagggg gtccccgccg tccagcggcg ggcgcagccc
    13801 ggtcatcagc acctcctgct cgaccagtga catgagcagc gcgtggatgc gctcggcggg
    13861 agcggccggg aactgcgcgc ccagggcggt ggagagctcg gcgaacggga tgagccggcg
    13921 ggcgccgcgc acggcggcgt cgacgatcgc cgagttgcgg atcgagacgc aggcgcggcc
    13981 gggctgcccg gccagcatgt cgggcgtcga cgggatgttc aggacgagcc ggtcgccgcg
    14041 gcggatcagg gcctggtggg cctgcaccgg cagacccggc agcaccacgg ggtcggtctc
    14101 gaggcgccgg acgagtgtca gcagccagcc catgtcggcg tgcgtgcggg tgcggtgccc
    14161 gccccgccac tcggctgtcg ccgtggtgtc gaaacgcccg gtcgtgacac cggcgaacag
    14221 cccgaacggg gtgggccggg tccgcatccg gatgtcgtag cgcagcaccg ccagggccgc
    14281 gcggcgcagc tgggtgagct tgaatgcgtc gccgtgcccg gcggcgaccc ggtccaggac
    14341 cgcggtcagt gtgggagtcg ccagggtcag cgcctcgacc agccgggcgt cacggttcgc
    14401 ggcccgcagc acggccaggt acgcggggcg cccgtcggcc gggtcggtgt cgggcgtaag
    14461 gcggctcgcg gcggacgtcg cggccagcgg cgcccgtacc agaaagtgat tccatgcacg
    14521 cagtgctcgg gtggacaacg ctcactcccc cggtgaggtc gaacagggac gaggtggtgc
    14581 cgggggccgc cggccgtgac cggcccgggc cctcggcacc aggcggtcag cagcagaagc
    14641 tgcagaatga gccgccgttc gggctgatgc atgtgggagt gcagatcaag ccgctgtggt
    14701 agatggccga cgtggtggtc tcgacggtta cctcgacgtc caggtcgaac acgtcatcga
    14761 tggtttcgtc ggccggcggc agctgggtga acaggtcgat gggcaaggtg gtcctccgtg
    14821 gtcgggtccg ggacgggacc gatggtcggc gatcggcgag aggtcagatg ccgggtggcg
    14881 tttctatccg ggtaacgggg aacgcgggcc cgggcctaga ggttttctgc cgccgcgctg
    14941 accagcctgc gtacccgggc ccgggccgcg gtgagagcgg cctccgcgga cttgtgcgtg
    15001 atgttgagcc gaccggcggc ctgccgggtg ctgaggccgt cggcccgggc ctggagcacg
    15061 gccagctggc ggccggtgag caggccgtcg aggcgctcgc ggatccacac cgcctcggcc
    15121 cggtcgcaca cggcctcctc gaacgacggg aggtgctgct cggcggcgcc gatccgggca
    15181 agaacccggt caccggtggt ccgggcccgg cagtggtcga tgcagagccg gatcacgatc
    15241 gtggtgagga tccgtccgac gtgctccgtg ggcagggtgg tggcgcaggc ggcccggatc
    15301 agtgcctcct gggcgcagtc ctcggcgtcg tgcgggttcg gcaaccgccg gcgagcgatg
    15361 cggaccagcc tgccgtggtg cggcgcgagc aggtcccagc ggtgctggcc ggaccggacc
    15421 ggggggccgg acggcaccgg ggtgtgatcg gcggtggtca gccgcggcat gaggtgctcc
    15481 gcgggtgggt gatggcctcg gcgccgtccg gtggtggatc cggccgggtg gatccgctac
    15541 ggcagccagc accgagcgat atcatgtgct tttgataggt ttgttcgacc acggcgcagg
    15601 cccagcacat ccgctggacg gcggtttccg gatgatcgcc gtaggcctgg gcgacttctc
    15661 cggcgcagcc gcgggtgccg ccgtacgcgc ggacagcgtg ccggatggcc gcgtctatct
    15721 gtgcgcggct gtggtgctcg gcggccgaca gatcgctggc gaacagcgcc tccgaacggg
    15781 ctgccgtgag cagggttcga cgtgggcggc cggcgcgtgt tgcccggtgt gacacgggcg
    15841 gagccgcccc tcgcgcggga ccggcacctt gcgggaaccc gctgctgacc gtcgcggtga
    15901 ccgggacgga gcaggtgccg gcggggagaa tggggcgctc ggtgacggct tgcggagtct
    15961 gttcggtgtc cccggccggc cgggccggtt gcgggcccgt gccggtgggt ggcggcatcg
    16021 cccgggtggt cgggatgccc gatgtcgagc ggcacatggt tacctccacg ttcgatgagg
    16081 gttggcaggt cccatggcac ctgtccgagg cgccgtccgg cgatgttccc ggacgaacgc
    16141 cggacagccg ggcggtgccg ccggacggcg ccgccgggac gtggagcgcc gggtgatgga
    16201 cgccgaccat cccgccgagg accggggcag cccggatccg gtgtccgcgt tcgcgtcgcg
    16261 gctgcgccgg ctgcaggcgg actcgggtgg cccgtcggtg cgcgacctgg aaagactcac
    16321 cgccaaggtg gccatgccgt acacccgcac caccatccag gacaagctga ccggacggtc
    16381 cgcggtgtcc tgggagttcg tggaggcgtt cgtacgagcg tgcgcgctgc acaccggcac
    16441 gcgcgcggag gtggacctgc ggccgtggcg cgcctggcac gcggagatga cccgcgacct
    16501 gaccgcccag cgtgccgggc gacgccggtc ggtgaaggcg gacgtctgcc cgtaccgagg
    16561 gctggaggtg ttctgcgccg agcacgccga gtggttccac gggcggacgg ccgccgtgca
    16621 gcacgtgctg gcggcgctgg ccgggcatca gcagggcgta ctgctgctgg gcccgtccgg
    16681 agccggcaag tcgtcactga tccaggccgg tgtggtgccc gcactgggcg cggggcggct
    16741 gcccggcagc gatcgctggc tgatcgtggt ggcccggccg ggcaaggacc tgctgggcga
    16801 gatggcccgc gccgggctgc ccgaggtgcg cgacgagccg atcgccgcgg cggtcgcgag
    16861 ccggctggcc gaccagccgg acacggcacg actgctgttg atcatcgacc agttcgagga
    16921 gctgctgacg ccgcctcgat ccgccgcgga gaccgactgg gacggccacc atgccggccg
    16981 ccgcgacgat gcccagcgcc agggcatcga gcagctcacc gcggcgatcg gcacgccggg
    17041 gctgagcgtg gtgctggtgg tacgggacga cttctacccc cggctggcct cgcaggcccc
    17101 ggcgctgctg gaccggctga ctgccgggct gatcaacgtg ccggcgctgc tgagcgcgca
    17161 cgacctgcag gacatcatca ccaaaccggc gcaggcggtc ggtctggcgt accaggacgg
    17221 cctgccggaa cggatcgtct cggacgtgct ggccgcgaac ccggacgccg cgcccgccct
    17281 gcacgccccg gtcaccgtgc tgccgctgct cgaactggca ctgcagcagc tgtggcaacg
    17341 ccggcagggc agcaccctga cgcacgaggc ctatcagcgc ctcggcggcc tcaccggagc
    17401 cgtggccacc tggtgcggcg ccgccgtcgc gcagctgccg gccgtgcagc gctcggtcgc
    17461 ccagcagatc ctgatcgcgc tggtccgtcc cgccgacgag acgcaccaca tccccgccat
    17521 gcggcagcag gccccgctcg cggcgctgcg cgagctggcc cggccgatcg gcgcgggcgg
    17581 cggggaatcc gcccccgaga tggtcgacga ggtgctcgcc gtgctgaccg gccagcggat
    17641 cgtcaccacc cgcatcgtcg gcgccgcgca acccgaccag cagcccggcg tcgacggggt
    17701 cgtgccggtg gccgagctgg tgcacgacgc cgtgatccgc gactggacga ccctgcggca
    17761 ctgggtcgcc caggaccagc gcttccagga ctggctgcgc cgggccgagg agcggcacgt
    17821 gcgctggagc gaccaccacg accccgacga cctgctgcac ggcagcgacc tggccgaagg
    17881 cgtcagctgg tcggcccacc ggccgctgcc ccacgacatc gccgcgttcc tgcagaccag
    17941 ccggcgccac cagcaggccc ggatccgccg ggcgcgccgg ttgaacgccg tcctggccgg
    18001 gttgctcgcc atcgccctga tggccgccgg tgtcgcgaca tggcagcggc gtaccgcggt
    18061 ggccgcccaa caggtggccc tgtcccggca gctggccgcg cagtcggcgg tcctgctgcc
    18121 caccaactcg gagctggccg atctgctcgc cgtgcaggcc taccggatca gccccaccga
    18181 ggaagccgtc gccagtctct acagcgcggt ctcgcagccc gtcgtccggg cgctgaccgg
    18241 ccacaccgac acggtgtccg aggtgaccta cagcccggac agacggcacc tggccaccgc
    18301 cggccacgac cggaccgtac gggtctggga cctggacacc ggcgggtcac gcacgctgag
    18361 cggccacagc gacgcggtgt ccgcggtcag ctaccgcccg gacggacggc agctggccag
    18421 cgccggccgc gaccggagcg tgcggatctg ggagctggac accggcgcgt cacgcgccct
    18481 caccggccac accggcgagg tctccgcggt ggcctaccac ccggacgggc ggcaggtcgc
    18541 cagcgccggc cgggacaaga cggtacggct atgggacctg ggcaccggca cgtcgcgcac
    18601 cctgaccggg cacaccgacg gggtctccgc ggtggcctac agcccggacg ggcggcacct
    18661 ggccaccgcc ggccacgaca ggaccgtacg actctgggac ctgggcaccg gcaagccgcg
    18721 caccctgacc gggcacaccg gcgccgtctc cgcggtggcc taccacccgg acggacggca
    18781 cctggccacc gccggccacg acaggaccgt acgactctgg gacctcggca ccggcaagcc
    18841 gcgcaccctg accggacaca ccgacgccat cctcaccgtc gcctacagcc cggacggccg
    18901 gcacctggcc agcgccggcc gcgaccggac cgtgcgggcc tggaacgtcg acgcgggcac
    18961 gtcgcgcgca ctgaccggcc acaccaactg ggtcttcacg gtggcctaca gcccggacgg
    19021 gcgccaggtc gccagcgccg gcggcgacga gacggtacgg ctctgggacc tcgacaccac
    19081 gcagtcacgc accctgtccg ggcacaccga cgcggcctcc gcggtggcgt acagcgcgga
    19141 cggacggcac ctggccagcg ccggccgcga ccggaccgtg cgggcctggg acctcgacac
    19201 cggcacgtcg cgcacgctga ccggccacac cgacgcggtg ttcgcggtgg cgtaccgccc
    19261 ggacgggcac caactggcca gtaccggccg cgacggcacg gtgcgggtct gggacctcga
    19321 caccggcgcg acccgcaccc tgaccgggca caccggcgcg gcttacacgg tggtgtacag
    19381 cccggacggg cggcaggtgg ccaccgccgg gcgcgaccgg accgtacggc tctgggatct
    19441 ggacaccggc acctcacgcg ccctcaccgg ccacaccgac cgggcctccg cggcggccta
    19501 ccgcccggac ggccaccagc tggccagcgg cggccgcgac aggacggtac ggctctggga
    19561 cctcgacacc ggcacgaccc gcaccctgac cggccacacc gacggggtgt ccgcggtgac
    19621 gtaccgtccg gacggccacc agctggccag cgccggccgc gacaagacgg tacggctctg
    19681 ggacctcgac accggcacga cccgcaccct gaccggccac accgccgagg tgttcacggt
    19741 ggcgtacagc ccggaccggc ggcacctggc caccgccggc cgggacaaga cggtacgggt
    19801 ctgggacctc gagaccggcg cgtaccgcac gctgaccggc cacaccgacg cggtcgccga
    19861 ggtgacctac agcccggacg ggcatcacct ggccagcgcg agctgggacg gcaccgtacg
    19921 ggtctgggcg aacgtcggct tgacgctgac cgcggcgatc gacctgatct gccgcaatct
    19981 cggccgcgat ctcaccccgg ccgaacgcgg gacgtacctg ccgtcggccg gctccgcccc
    20041 gccggcctgc cccgcgccgg acggttgagg tcccggcccg gcgcggcggc ggatcacccg
    20101 cagcggcgca gggtctgctc caggatgcgc cgggtgtcct ccggcttgca ggccacgatc
    20161 ccgatctcgc tccaggcgat ccggtacggc tccgacttgg cgacgtcctc gatgaacagg
    20221 gcgtcgtcga gctgctccag gtagaccacc tcggacaggc gcgcgctgcg caggcgcagg
    20281 atggagaagg agttgctccg ggcggcgcag gcgccacgct tgacgatctg gatcctgacg
    20341 tgcggcagat cggtggctct gatcaggaag tcgagctgcc ggcgcatgac ggccggatcg
    20401 tcgagaccgt cctccagcgc cgcgttgtcg atgatcgccc agatctgcga ggcgcgccgc
    20461 cgcaggatgc tggcctgccg tcgcatccgc acgtccacgc gccgctggat gtcctcctcg
    20521 tcggtgtagc gatcacggat ggtggcctcg gcgtactcgc gggtctgcag cagtcccggg
    20581 atgaaccggt tctcataggt gtagatgtac tgggcgaccg actccagcag cagataggag
    20641 cggtaccact cggcgaggga attgctgtag ggcgcccacc acggcttctc gttgagccgg
    20701 gcgttcaggc tcagcagcgc cgcacgctca cgggcgtcgt gcatgcggta gtacgtcaga
    20761 agggtgtcga gatcggcgtc cttgaacggg acctgtccca gctccagccg ggacaccttg
    20821 gccgggtgac accggagatg cttggcggcg tcctcccggc tgatgccgca ttcttcccga
    20881 aggatgcgca gctggcggcc gagcatcgcg agcgccgtgc tcgggcgccc ccggccttct
    20941 gacgcctgag cctcggtgga tggcacttca cactctccgg tgacgtgttt gcgggggtcc
    21001 tgctggtggg cgacgggtgt gtcgacggcg aagatcatcg gtgggtccgc ctcagcgccg
    21061 ggccgagcgg ccgggcagga ggcgatgcgc cagcctgctg gacagggcga cgcaggccgt
    21121 gccggcgatc gtcgcgaggt ggggttggcc gaacacggcg gccgccaggg agaagcccat
    21181 cagcaggacg gcgaccgtga gcacgagggc agctctgtgg tcacgggcgc cggccggcgg
    21241 cgggacgggg acgtcgggtc cgcttcggcg ttgaccttct cggtttcgca cgaggcgtat
    21301 cgtccatgcg gcgaccacag tgggcaagtg cctatgcact tgtgcatgca cgtgcagatg
    21361 cagcgcgcac gactcggcgc caggtccggc accagcgcgg cggacgtcgc gccatcgccg
    21421 tccgacaacc gacgccgggc aggcgcgtca cccgcacgag ggaccacttc ggcccggaga
    21481 tccgcggcgg gcccggcggc gcccgggacc ggcacgtcgc gcggtcccgg cgcgggaccg
    21541 gatgggccgg cgcggtcccc gcgcggggcc ggatgggccg gcgcggtccc ggcgcggggc
    21601 cggatgggcc ggcgcggtcc ccgcgcgggg ccggatgggc cggcgcggtc cccgcgcggg
    21661 gccggatggg ccggcgcggt ccccgcgcgg ggccggatgg gccggcgcgg tccccgcgcg
    21721 gggccggatg gatgatccgg gggcggcgag ggctaggccg cgtttcgtaa gtgcgggcga
    21781 ggtgtgacgt gtcccggcgt ggcggttgtc gatacgaagt gaggtctccg gtaaacgggt
    21841 tagcgaccaa gcaaacctga accaccggag acctcgtgcc cagggtagcg gcagcgaggc
    21901 gacacgatct caccgacgtt cagtgggcgg tgctggaacc tgcgctgcct gcggagccac
    21961 ggcgaggccg tccgccgcga tggacgaaac ggcagatcat cgatgggatc cggtggcggg
    22021 tccgggcggg aacaccgtgg cgggacgtgc ccgaggtgta cgcaccctgg cagacgttgt
    22081 atcgctggtt ccggcgctgg cagcgcgacg ggacgtgggc gaagatcctg gcccggctcc
    22141 agacccgggc cgacgccgcc ggtgacatcg agtgggcggt gagcgtcgat tccacgatca
    22201 gccgtgccca tcagcatgcc gcgggtgccc gtcgtgatgg tgacctgcag aaggaaccgc
    22261 cgggtggggt gttcgccgaa cccggcgatc atgctctggg caggtcccgg ggcgggttca
    22321 ccaccaagac ccatctggcc tgtgagcagg gtcgtaagac gctgtcgacg gtgatcaccg
    22381 ctggtcagcg gggtgacagc ccgcagttca tcaaggtcct ggaacgcatc aaggtctatc
    22441 gggtcggtgg tggccggccc cgtacccggc cggatctggt cctggcggac aaggcgtaca
    22501 ccagccgggg caatcgcggg tacgcccgcc gccgcaggat cagggtgtgc atcccgagca
    22561 aggccgacca ggacgcctac cgcaaggcca aaggctccaa gggcgggcgt cctccggcgt
    22621 tcgacccggt cgtgtaccgg cagcgtcacg ccgtggaatg cggcatcaac cagctcaaac
    22681 agaaccgggc gatggccacc cggtacgaca agcttgccgt ccgcttcgaa gccaccgtca
    22741 ccatcgccgt catcaaccaa tggctctgat gacctttacg aaacgcggcc tagcgccggg
    22801 ggcacccgcg gggcagtccg atgagcagcg ccgcgccgac ggtcaggtgc ataccgacca
    22861 gcgccagcct gctgccggcg tcgacgccgc tgcccagcgg accggccagg gagagcagca
    22921 gcacgagcag gccgatcatc cggaacgtcc gggcgggccg ccgggtgtgc cgctccagca
    22981 gggcgagcag gccccaggcg accagccccg cggccagcgc ggccggcacg accgcggccg
    23041 gaccgatctg ctcgacgccg ccgccgcggc ggacggtcgg gtcggcgccg gccagcgggc
    23101 cgttgaccgc ccagatcagc agggcgccgg ccgctgcggc ggcgacggtg agcgcgcggc
    23161 cggcgcgccg ccggatggtg gggtgggtgc tggtgggctc ggcgaggtgc ttgtcgttcg
    23221 tcatgccgac gagcgtcccg gcccggaccg gtacgccaca tcggaccgcc ggccgcgcgc
    23281 ccgctcactt ccgcaccggc ggcctaccac tttcgatggt gtcgccgccg gtgacccgcc
    23341 ggttagcctc gcccgatgac gagcctcctc acccggcggg ccggcggcca cggtcccggc
    23401 gccggcgcgg tcgcggcgat gctgggcatc tgcgggccgc tgatcgcggc caccgtgctg
    23461 ggctggtgga gcggccgccc gcccgggccg ccgctcgccc tggacgtcgt cgccgggctc
    23521 ctgagctggc tgctcacgcc gctgctgctg tggcggccgg gcgccaccac ggcggtgctg
    23581 tccgcgctgg ccgcggtgtc cccggcggcc accccggccg ccacgaccgg tgcgctgcag
    23641 gtggcgcggc gccgccgctt cccgctcgcg atcgcggtga ccgccggcgg gatcggggcg
    23701 cacgcggtcc agggcgcctg gcgctccaac ggcggcatgt cgtacgggtg gtggctggtc
    23761 ctgatcaccg tcgggtacgg cgcgctgctc ggctggggcg cgtgggcgca ggcccggcag
    23821 gcgctgatcc actcgctgcg cgagcgggcc cgccgcgccg aggcggagca gggccggcgg
    23881 gtcgccgagg cccggatgct ggaacgccgc aagatcgctc acgagatgca cgacgtgctc
    23941 gcgcaccggc tgtcgctgct ggcgacgttc gccggcgcga tggagtaccg cccggactcc
    24001 tcgccggagc agatgtcgcg ggccgccggc gtggtccgcg acggcgtgca ccaggcgctg
    24061 gaggagctgc gcgaggtcat ctcgctgctg cgcgacgacg ggccgccgga cgacgagacg
    24121 gtccgcccgc agccggtgct caccgacgtc ccgcgcctgg tcgaggagtc ccgcggggcc
    24181 ggcgtcgagg tgctgctgcg cgagacggtg gaccggcccg gcgaggcgcc gccggcggtg
    24241 gcccgcaccg cgtaccgggt catccaggag ggcctgacca acgcccgcaa acacgcgacc
    24301 gggcggccgg tgcacgtcga ggtgcgcggt ggtcccggcg ccgggctgga gatctgcgta
    24361 cgcaaccggc tcgccccgcc cggcgccacg ccgcccgcct ggtccggcgg ggccggactg
    24421 gtcgggctca ccgaacgggt gcgcctggcc ggcgggcggc tcgaccacga gtcggccggc
    24481 ggcgagttcc ggttacgcgc gtcgatacca tggccggcat gaacccgccg gtgcgcgt
//
