LOCUS       NZ_CP023865            21125 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2419150
            Orig. end                         :: 2440275
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21125
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="6"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21125
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21125
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11125](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11125
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     misc_feature    complement(128..142)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            complement(498..1256)
                     /locus_tag="ACTEI_RS10895"
     CDS             complement(498..1256)
                     /NRPS_PKS="Domain: PKS_KR (14-166). E-value: 6.7e-11.
                     Score: 34.4. Matches aSDomain:
                     nrpspksdomains_ACTEI_RS10895_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020524931.1"
                     /locus_tag="ACTEI_RS10895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_275412255.1"
                     /sec_met_domain="adh_short (E-value: 2.7e-29, bitscore:
                     101.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAAASMFSLHGRTALVTGSRNGIGRAIAVALAQAGADLVLHGR
                     TDDLDDVEEEVRKAGGTASRWRFDLSDTAGIPAAVADLPEVDILVNNAGIIRRAPAAGH
                     SFADWRSVLDVNLDAVFQLSRAIGVRMLARRRGKIISVASMLSFQGGVQVPGYTAAKHG
                     LAGLTKALACEWAADGVQVNAVAPGYISTGNTAALRADPVREAEIRSRIPAGRWGRPDD
                     VAGAVVFLASAASDYVNGHVLAVDGGWLAR"
     aSDomain        complement(759..1214)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTEI_RS10895_PKS_KR.1"
                     /evalue="6.70E-11"
                     /label="ACTEI_RS10895_PKS_KR.1"
                     /locus_tag="ACTEI_RS10895"
                     /protein_end="166"
                     /protein_start="14"
                     /score="34.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSRNGIGRAIAVALAQAGADLVLHGRTDDLDDVEEEVRKA
                     GGTASRWRFDLSDTAGIPAAVADLPEVDILVNNAGIIRRAPAAGHSFADWRSVLDVNLD
                     AVFQLSRAIGVRMLARRRGKIISVASMLSFQGGVQVPGYTAAKHGLAG"
     CDS_motif       complement(1119..1190)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTEI_RS10895_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ACTEI_RS10895"
                     /protein_end="46"
                     /protein_start="22"
                     /score="10.7"
                     /tool="antismash"
                     /translation="NGIGRAIAVALAQAGADLVLHGRT"
     gene            complement(1253..2053)
                     /gene="kduI"
                     /locus_tag="ACTEI_RS10900"
     CDS             complement(1253..2053)
                     /EC_number="5.3.1.17"
                     /GO_function="GO:0008697 -
                     4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0045490 - pectin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="kduI"
                     /inference="COORDINATES: protein motif:HMM:NF002091.1"
                     /locus_tag="ACTEI_RS10900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5-dehydro-4-deoxy-D-glucuronate isomerase"
                     /protein_id="WP_122982061.1"
                     /transl_table=11
                     /translation="MDSRPPTAPDQLATMDTARLRARFLVEDLFRPGEVRLTYSHEDRI
                     VVGGVSGAAELPCPDALRSAYFLERRELGVVNIGGPGTVTVDGVRHELAAREVLYIGRG
                     ARQVRFDGRFYLVSTPAHTSHPTVKATLDDAEPVRLGSRENSNERTIYKYIHLKGIQSC
                     QLVLGVTVLEPGSMWNTMPCHTHERRTEVYFYFDLPESDRVVHLMGPPDATRNLIVAPE
                     QAVISPYWSVHCGFGTRSYAFVWAMGGENQAYDDVEPVAIGDLR"
     misc_feature    complement(2072..2089)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.6"
                     /tool="antismash"
     gene            complement(2143..3642)
                     /locus_tag="ACTEI_RS10905"
     CDS             complement(2143..3642)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012686.4"
                     /locus_tag="ACTEI_RS10905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_122977544.1"
                     /transl_table=11
                     /translation="MTTLDWLVLSGYFLVMLGIGLWAKGRIHSVADYFTARGMIPWWLS
                     GISHHMSGYSAIMFVAFAAVAYTYGLAMYVWWALTIGLGVGIGAFLFAARWNRLRSRHG
                     VASPLEYLARRYNVPTQQVLAYSGALLKVVDIAAKWVAIAVLLRGFAGVPILWGIVITG
                     AVTLVYITAGGLWADVLTDFGQFVIQGVAGVAMFLAFLGHLGGVSALWNMWDDLPAGHG
                     DPFHGPYTLTFFLALLFIKTFEYNGGMWNLAQRYMAAPSGSAAKRSALLSSALWLVWPL
                     ILFMPMFAAPLIVPGLTNPEQAYVELAKSLLPPGVIGLVLAGFFSHTMAMVSSDANVIS
                     SVVTRDIAPVLVRAVRHLSERGALTFARITTFAFVAISMVIAISTEGQGVVLKIVVDLV
                     AATMGPISIPLMLGLLPWFRRCGPTAAIASWAAGLGVWVVVKWILDETSQTMVVGVPLV
                     TSLVLYTAIGLLKPERTMERDTIIDSLDSDPADEARPVTTA"
     misc_feature    complement(3659..3674)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            3818..4006
                     /locus_tag="ACTEI_RS10910"
     CDS             3818..4006
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006725 - cellular aromatic compound
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013522.4"
                     /locus_tag="ACTEI_RS10910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tautomerase family protein"
                     /protein_id="WP_122977545.1"
                     /transl_table=11
                     /translation="MPNITVELLSGRTLDQRREFAEAVTAAAVDILKARRAAVRIRFDE
                     IEREDVANGGTLESDRT"
     gene            4386..5063
                     /locus_tag="ACTEI_RS10915"
     CDS             4386..5063
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476575.1"
                     /locus_tag="ACTEI_RS10915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_122977546.1"
                     /sec_met_domain="HAD_2 (E-value: 2.1e-28, bitscore: 98.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTGSGSPLVEAVIFDMDGTLIESTDVVTAAFRAAVVAGGGPVF
                     SDADIVAAYPLGPPRRILEHLLGRPVTSGELDLYYSHLASGRVRTYDGVEHVLSLIAQR
                     ASVAVFTGASRKAAQILLGGAGLLGFFAVVVGGDEVAHPKPEPDGILLACDRLGVEPGS
                     VAYVGDSPLDLRAARRAGALAVAAAWGHLYDAGQAADRTARQPIDLCALVSPQASRDTV
                     LPA"
     gene            5587..6546
                     /locus_tag="ACTEI_RS10920"
     CDS             5587..6546
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014273.4"
                     /locus_tag="ACTEI_RS10920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ParB N-terminal domain-containing protein"
                     /protein_id="WP_164465910.1"
                     /transl_table=11
                     /translation="MDDITPTYFAELNGALPAGKAELVPIASLSSAWTPRQTALDERHV
                     QLLAQSEAPLPPILVQRSTMRVIDGVHRLHAARRNGAEEILAHLLEDDDRAAYLRSVAS
                     NVAHGLPLTLAERRAAAKRLLEWFPQCSDRSIGRVSGLSGKTVAALRKRSGTGMPAERI
                     GRDGRVRPARPGADRLLVEELITQHPHASLRDLARRAGVSPNTVRNARLRMIHRGPGTD
                     RPAGAPGAEGAPAGQDFAPDDVVLTNLSRDPSLRYTETGRTLLRLLHQHLGTSLDGQVV
                     ESLPPHCLPLVSKVARSVAMQWKQFAEIAEGRANASAL"
     misc_feature    5749..5751
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7144..8220
                     /locus_tag="ACTEI_RS10925"
     CDS             7144..8220
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014734.4"
                     /locus_tag="ACTEI_RS10925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_203723607.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.2e-05,
                     bitscore: 22.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGIARTLAGCVVAGADDGAEDYCPPYWRSSEPLFRRAHDVVAA
                     VAARYAPVASGLAGVVSGGRPAAGYPPLVEALERYAREPGWSREHRDLAASIERSVRLL
                     YFEGAPEPAVRPAPDRLAPAGALPALHVVIPFRAPRGSLRERNLRACLRSLAQQASGSS
                     GFYVTVVESDDRPRHSWVGSWADNYVFEPQSGPFNKSSSVNFGARRSRSPRDVICELDA
                     DMVVDPWFITRVRVQAAVSPAFLPYEDVHCLDPESSARLVSERTAGAGTVAGYLLRRPP
                     GGCVVVTAELFRAVDGFDTSFTGWGGEDRDFVDRLSAFSPVARSAATMIHLNHERPSMN
                     RAAQFATGDREAVTQEVG"
     gene            8222..8959
                     /gene="pgl"
                     /locus_tag="ACTEI_RS10930"
     CDS             8222..8959
                     /EC_number="3.1.1.31"
                     /GO_function="GO:0017057 - 6-phosphogluconolactonase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pgl"
                     /inference="COORDINATES: protein motif:HMM:TIGR01198.1"
                     /locus_tag="ACTEI_RS10930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-phosphogluconolactonase"
                     /protein_id="WP_203723606.1"
                     /transl_table=11
                     /translation="MPELAQHQDLVVTRAAGFADLAEQVSARVVEHIDRVLRQHEFCTV
                     ALTGGSTPAATYRSLSAADLPWDRIHVLQTDDHIVADSETGPSWSVIERDLLHRCAVPV
                     ANRHPMPVRTGPGLASAVRRYDMQIRSLLRGQSPDVVVLGLGEDGHTASIFDGDPSALT
                     ADRVVVTTAPYHGVTRMTLTLPTLARGGLRVVLACGTAKAAAVAGLLGEGAPRTSAVAG
                     ILRGGGMLFVDDAAMSVADAATG"
     gene            8972..9991
                     /locus_tag="ACTEI_RS10935"
     CDS             8972..9991
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.4"
                     /locus_tag="ACTEI_RS10935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family protein"
                     /protein_id="WP_122977548.1"
                     /transl_table=11
                     /translation="MDPILCLDLGGTWFRAGILGADGRLRLVRKTPALSVRNHREPVAK
                     LQQRLVDHIVTATLEADAACGVATVGISLGAALNGRTGEVFGSAPLWGPGRHPMPLTDL
                     LARRLPDVRFGLLNDVTALAHAVRARWAATRPGRRAAAVTVSSGIAYRTIVLESGRIPL
                     EPRYGLQGEIGHLPVDVEWRGSVLRGRCDCGGENHLSAFSSGRGLERLLATLPEARAFR
                     ELPGQPVATFSRRVAGADPAALEILDLFTRPLAKVLLYQATLDPEVGATVLFGGVVEAL
                     GAHYLESLVRNLEELGLYGISDRDPQYFRTRIHLGDDDGLAAMRGVGSYLRDRLHRND"
     gene            10001..11125
                     /locus_tag="ACTEI_RS10940"
     CDS             10001..11125
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014690647.1"
                     /locus_tag="ACTEI_RS10940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_122977549.1"
                     /sec_met_domain="salQ (E-value: 3.8e-152, bitscore: 505.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 3e-09, bitscore: 34.9,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 1.1e-70, bitscore:
                     236.5, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGWTVRCRQDVTYRINAVVDVFSPANEALAEAADVADGKRYLVV
                     VDRTVDSLYGDRIDRYFGARGARTVKYTLGPGERVKTADSLLDIARTADQAGIRRRCEP
                     IIAVGGGVVTDLAGMAASLYRRGTPFIRVPTTLVGLVDAAIGAKTAINHNGHKNRLGTY
                     FPAAHTLLDPTFLRTLPARHVRNGMAEIVKIAVMKDATLFALLEADSADLVESRIATAH
                     GTEIIERSVTAMLGELEANLWEHELRRVADFGHTFSPQLEMCAGDLLHGEAVAIDMALC
                     CAIAHLRGLLSDDALRRVFALLQGLGLPTEHEACTSRMLLGALADTVRHRDGHQHLPLP
                     TGIGSAVFVEDVTPAEIAAARDTVRRLQPIAANR"
     gene            11122..12183
                     /locus_tag="ACTEI_RS10945"
     CDS             11122..12183
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS10945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="medium chain dehydrogenase/reductase family
                     protein"
                     /protein_id="WP_122977550.1"
                     /transl_table=11
                     /translation="MTGRDDLRVLRAGICGTDLQIFRRVRPDRAGILGHEGVAERAATA
                     DGRRRFVVFNPVDPDDQDSILGHSYDGIFRRHVPGGAERMPRTVPVDPRLPADLAALVE
                     PLGTVLYGWELASSAAPLRSVSVWGGGTSALLVAIVAQLHGCDVELVHRRGERLRFIDG
                     LGVLDGARLRLPGAAPAVAGCDGAFLCLPREGAAAGLTQAVDQVRPGGCIDLFGGFGPG
                     DRHPATGRLDLGMVRRANVCGRPVGSATAEVRTPAGKPVSLTGHRGTAERHLTRAAELL
                     RTHASRFGALITHVVPLAEAGSYLSAMASGSRAPAPPYEYVKVVIDMTLVSAGTRGPDL
                     STRLADLPVECPV"
     gene            12180..13235
                     /locus_tag="ACTEI_RS10950"
     CDS             12180..13235
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS10950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_122977551.1"
                     /sec_met_domain="ADH_N (E-value: 4.4e-05, bitscore: 22.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGVAYRRIGHRDGVAYLERARTGRLTDQPARVVIAPLVVGVCRS
                     DLRELDGTRHLRRDFGHEIVAEVRYSTLADTLPVGRRVVLDPHPVVRRTSGFADLVEIE
                     GTVADVAAALRPVPADSDPLAALFTEPLACAAHCLARVDAVIAATAHARPSPVAVVGAG
                     IAGTLMAGILRSRGTEVHLVNRGGQRLRFLAERDVLPGVDLHPADRPGRGGFACVVLAT
                     AAATGAALELAAGLTGDDGVLMIYAGTEPGSRFLGQDIDAIRRGEGRVTVHDGRRRMHL
                     AGSHGATAADFAVATRLLQDRREGPALRRTVRRLIDVEAPLDEGPALLREMVSRPYVGK
                     AVLTPGVPDRG"
     gene            13246..14349
                     /locus_tag="ACTEI_RS10955"
     CDS             13246..14349
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (35-163). E-value: 3.8e-11.
                     Score: 34.4. Matches aSDomain:
                     nrpspksdomains_ACTEI_RS10955_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.4"
                     /locus_tag="ACTEI_RS10955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_122977552.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2e-08, bitscore:
                     32.6, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.4e-117,
                     bitscore: 389.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2.6e-08, bitscore:
                     31.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAKYHYAAQFRHLPRVVRAIDDLLVRGDYVLGPHVEQFEQDFA
                     DYIGVEHAVGVNSGTDALVLALRALGVGPGDEVVTVANTFHATVLAITTVGARPVLVDC
                     TPHDYLMDLEQVEAAITGRTRAIIAVHLFGKALDMAAVTAIAERHGLAVVEDCAQAVGA
                     SWQGRRVGSWGDIGCFSFHPSKNLAAAGDAGAVTTDRADLARTIRTLRGLGQAAQNDHV
                     ALGCNSKLDAIQAIVLSHKLPELDGWNAGRRAVAGRYSRALAGIARVPEPAGREHVFHL
                     YQVGVEQRDEVLAELVGAGIDAVVRYPVPIHRQPAFAHLDLPSRFPHADWQAAHTLCLP
                     VRPDLTGTEIDYIVDQVTSAVAKRTGA"
     aSDomain        13351..13734
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTEI_RS10955_Aminotran_5.1"
                     /evalue="3.80E-11"
                     /label="ACTEI_RS10955_Aminotran_5.1"
                     /locus_tag="ACTEI_RS10955"
                     /protein_end="163"
                     /protein_start="35"
                     /score="34.4"
                     /tool="antismash"
                     /translation="HVEQFEQDFADYIGVEHAVGVNSGTDALVLALRALGVGPGDEVVT
                     VANTFHATVLAITTVGARPVLVDCTPHDYLMDLEQVEAAITGRTRAIIAVHLFGKALDM
                     AAVTAIAERHGLAVVEDCAQAVGA"
     gene            14346..15008
                     /locus_tag="ACTEI_RS10960"
     CDS             14346..15008
                     /EC_number="5.1.3.1"
                     /GO_function="GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013030.4"
                     /locus_tag="ACTEI_RS10960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="WP_203723605.1"
                     /transl_table=11
                     /translation="MTVVEVLPALLGADPLALGAATDSLVGAPVRYLHLDVMDGAFVPD
                     ISFGARTVTAVRRRTELPLDVHLQVANPEAHLDALLAAKVDLVTVHVESTAHVARLLRR
                     LRLAGVDAALAVNPGTPLGSLAELLGEIVQVTVMTSNPGTSDFLEYTLDKIRRLRALLA
                     ESRLEHVHIAADGGVTEARARALHEAGADRLIAGSAVFQAPGGVVDGVARLREAALS"
     gene            15005..15679
                     /locus_tag="ACTEI_RS10965"
     CDS             15005..15679
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="ACTEI_RS10965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_122977553.1"
                     /sec_met_domain="HAD_2 (E-value: 4.9e-21, bitscore: 74.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVHARGLLFDLDGVLVDSSAAIRRAWWEWAGAKGLDPATTFAA
                     GHGRQTMDHIRAVAPHLAVPAEERRIDELEARYADAVEPQPGAGPLVASLAEVPWGVVT
                     SCSAQAARTRLERAGIGVPPVLVHAGDVGRGKPHPDGYLRGAELIGVDPAEVVVFEDAP
                     SGIEAAVAAGMRVAGVCTTHDPHQLAGAAWLVEDLSTVRVTRSVDSATLLVHLRECDAA
                     RR"
     gene            15663..16877
                     /locus_tag="ACTEI_RS10970"
     CDS             15663..16877
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037610.4"
                     /locus_tag="ACTEI_RS10970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_122977554.1"
                     /transl_table=11
                     /translation="MLRVGEVSADYVRFTRSALKLHYGIDLPETAVAAKAALARPGGFL
                     TIGDPGVIGAAAIFPFDMTVAPGETLPVSGIGDVAVSPNHRRRGWLAALMREHLRSAAE
                     HGDALTVLTASEAAIYGRFGYAPVTEAASWSLHTEGLELRSRPVTGAVELLDDPSAATA
                     VPEAFSAYQRGAPGELARSARWWTTRWNDPVAVGAPADTFVALYRDGQGRPTGYATWSR
                     GGPWTPYHGPGVVEVDEFVAAGPEAAYALLAFLRSLDLCREIVFRKRPVGEPLREHLAD
                     IRRLRMAERVDKLWARVADVPRVVRACTAGIDRVVTIAVHDPGTGSTGRYTLTPDGDRV
                     ACRPGAHAPDLTLSSADLTACLLGAVSIVELARRGRIDGGDRGALLAVARALAGQTTPH
                     CSTGF"
     gene            16914..17864
                     /locus_tag="ACTEI_RS10975"
     CDS             16914..17864
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020133.4"
                     /locus_tag="ACTEI_RS10975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_164465911.1"
                     /transl_table=11
                     /translation="MIISTNTRVCLAGEDLDWLGYRSVCVAVDLPTRIAIRPDCADESG
                     GVTRTANAVWQFLRQRVERVPARRPGVVVDADAPLASGLSSSSSLIIGLFRAFAGHLDL
                     PLGDETLLSWSFDFEYAICHGGGMDQTAIIRGDTVLTAGRDGTPPLLLGHARFPADWRL
                     IVVDSAMPKSTVGHLAEARRRHAEGDSRLSRYIAHADRAAASAWDAVLAEDLPALVAAM
                     ERAHRAMREVGMSSAVLEDLRAIARAEAGISLKITGAGGGGAMIGVCRDVDAVSVATRL
                     RAAAGARYAGSSVLIARAAAGPAVLSAASESTVAG"
     gene            17867..18352
                     /locus_tag="ACTEI_RS10980"
     CDS             17867..18352
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014447230.1"
                     /locus_tag="ACTEI_RS10980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_122977556.1"
                     /transl_table=11
                     /translation="MPTPDFILELRKSIGTAPLWLSGVTAVVLHEGRILLNRRSDNGRW
                     ALLHGILEPGEQPGVAVVREVFEETGVTVSVERLSSVFSLPPGVCANGDRVQFLDLTFV
                     CRLVGGEARVNDDESLAVAWFHLDTLPPMAEADRFLLDKALAAEASPWFVTDPGDLP"
     gene            18395..19612
                     /locus_tag="ACTEI_RS10985"
     CDS             18395..19612
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="ACTEI_RS10985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_203723604.1"
                     /transl_table=11
                     /translation="MVSWRPAAVLPVMPSRGLRRLMLSVLVDTAGAGLFLPLSLLFLVE
                     VRAIAPAVAGTAVTAGSLVSFLVIPVAARLIQRYGARHCLMASNVLTAGGYGLYFVADG
                     FGSVLGAALLVMSADRLYGAAWPTALARVADGEELTRWFSFVNFVKTACLGTGAVAATG
                     LLAVAGRSGLSVALAVNAISSVVAAAVLVGVALPERGADPAGSGGGRSSVWSALRDQRF
                     RSLVLSQTLLSFAWLIPTIAFPVYLVSVLGLPAYWPTLVVTARYAGIAVLQMPLSRLTA
                     RSTRARVLAGAIALAGCAVAVTAAIPLLPAACTGAAAVLVAALLAVAELTSKPTAAAAA
                     VRLAPPGDEGPYMAVFQLTWTVSYAVGPAIIGIGLGRPLLLWIGIGLAVLGSGVAHLHG
                     RARVRT"
     gene            19695..20738
                     /locus_tag="ACTEI_RS10990"
     CDS             19695..20738
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017532.4"
                     /locus_tag="ACTEI_RS10990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_122977557.1"
                     /sec_met_domain="PhyH (E-value: 8.7e-10, bitscore: 37.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSHDGYLHRAASHRPYFSRDGDTYLAETPLRDLRKAHQLRVLSE
                     EDFAFWQTYGYIVVREAVPSEHARRLLAFAFAFQGLDPDRPQTWYPEREYASELERDLY
                     IYGFVEAYQHQLIWDSRQSQRVYDAFVDVWDVPELWVTLDRLNINPPNVGNRDRALIPA
                     TDRGFDIDLHWDVDTTLPVMPQRVQGLIALNDTRPELGGFQCSPELFRRFDQWRVQQPA
                     DRDPVRPDVDRSEFPVIQPELRAGDLLIWNGQVAHGVLPNRSRDGVRAVQYLSMMPALP
                     GHRELVRSRIRSWRELSTPEWNATLIGDPIRHESQRYGPAKLTDLGERLLGCTPWDTVA
                     GSGPRER"
ORIGIN
        1 cccccgcacc tcgtcgtcgc cgagctcggc caggatcgcc ttgccgatgg ccgtggtgtg
       61 cagggcgatg ctcatgccga tgcgggacgg catctggtac ggccggcgcc cctcctgctt
      121 gtcgacgtag accgcctcgt ccacgctgcg gatcgcgaag tgggtggtga agccggtggc
      181 ctcacgcagg gcgagcagcg cgccggacgc ctgccgggcc gggtcgaagc ggtgcatcac
      241 ccggcccgcc agggtgagga tgcgcgggcc gggctcgtag ctgcccaggc cgtccggacg
      301 ggcgaagccc cacgtgacca gcgcctgcag gatccggtgc acggtcgact tcgagacgcc
      361 ggtcgccgcc gcgatgtcgg tgacgcggtg gtgctcggcg agcgcttcga gcaccgccag
      421 cgtcttgtcg atggaactgc cttccctggc caccgattca gcctactggg agccggtcgg
      481 cgggccgggc tcggcggcta ccgggcgagc catccgccgt ccaccgcgag cacgtggccg
      541 ttgacgtagt cggaggcggc ggaggcgagg aagaccaccg cgccggccac gtcgtccggc
      601 cggccccagc ggccggccgg gatgcgcgac ctgatctccg cctcacgcac cgggtcggca
      661 cgcagggcgg cggtgttgcc ggtcgagatg tagcccgggg cgaccgcgtt gacctgcacc
      721 ccgtcggcag cccactcgca ggccagggcc ttggtcagcc cggcgaggcc gtgcttggcg
      781 gcggtgtatc cggggacctg cacgccgccc tggaaggaca gcatcgaggc caccgagatg
      841 attttgccgc ggcggcgggc cagcatgcgt acgccgatcg cgcggctgag ctggaacacc
      901 gcgtccaggt tgacgtccag caccgagcgc cagtcggcga aggagtgccc ggcggcgggc
      961 gcgcggcgga tgatgccggc gttgttgacc aggatgtcca cctcgggcag gtcggccacc
     1021 gcggccggga tgccggccgt gtcggacaga tcgaaccgcc accgcgaggc ggtgccgccg
     1081 gccttgcgga cctcctcctc gacgtcgtcc agatcatcgg tacggccgtg cagcaccaga
     1141 tcggcgccgg cctgcgccag ggccaccgcg atggcccggc cgatcccgtt gcgcgagccg
     1201 gtgaccaggg cggtccggcc gtgcagcgag aacatcgacg cggcggcgcc ggtcaccgca
     1261 ggtcgccgat cgcgaccggc tccacgtcgt cgtacgcctg gttctccccg cccatggccc
     1321 agacgaacgc gtagctgcgg gtgccgaatc cgcagtgcac cgaccagtac ggcgagatca
     1381 ccgcctgctc cggcgccacg atcaggttgc gggtggcgtc cggcgggccc atcaggtgca
     1441 ccacccggtc ggactcgggc aggtcgaagt agaagtagac ctcggtgcgc cgctcgtggg
     1501 tgtggcacgg catggtgttc cacatgctgc ccggttccag caccgtgacg ccgagcacca
     1561 gctggcagct ctggatgccc ttgagatgga tgtacttgta gatggtgcgt tcgttggagt
     1621 tctcccggga gcccaggcgc accggctcgg cgtcgtcaag ggtcgccttg accgtcgggt
     1681 ggctggtgtg cgcgggcgtg gagaccaggt agaaccggcc gtcgaaacgg acctggcggg
     1741 cgccgcggcc gatgtagagc acctcccggg cggccagctc gtgccggacg ccgtccacgg
     1801 tcaccgtgcc cgggccgccg atgttgacca cgcccagctc gcggcgctcc aggaagtacg
     1861 ccgagcgcag cgcgtcgggg cagggcagct cggcggcgcc ggacacgccg ccgaccacga
     1921 tgcggtcctc gtgggagtag gtcaggcgta cctcaccggg acggaacagg tcctccacca
     1981 ggaaacgggc ccgcagccgc gcggtgtcca tggtcgccag ctggtccggg gccgtggggg
     2041 gtcgtgagtc catcagcact cctcgcatcc cgttacatga aacaaactat cgctacatgg
     2101 aacagcatat cggcctcgtc cggcggcgcg cggaccgccg ggtcaggccg tggtcaccgg
     2161 cctcgcctcg tccgccgggt cactgtcgag tgaatcgatg atggtgtcgc gctccatcgt
     2221 gcgttccggc ttgagcaggc cgatcgctgt gtacagcacc agcgaggtga ccagcgggac
     2281 gccgaccacc atggtctggc tggtctcgtc caggatccac ttgaccacga cccagacgcc
     2341 caggccggcg gcccaggagg cgatcgccgc ggtcggcccg cagcgccgga accagggcag
     2401 cagcccgagc atcagcggga tcgagatcgg ccccatggtc gccgcgacca ggtccaccac
     2461 gatcttgagc accacgccct ggccctcggt gctgatcgcg atgaccatgc tgatcgccac
     2521 gaacgcgaac gtggtgatcc gggcgaacgt gagcgccccc cgctcgctga ggtggcgtac
     2581 cgcgcgcacc agcaccgggg cgatgtcgcg ggtgaccacc gacgagatca cgttggcgtc
     2641 cgacgacacc atcgccatcg tgtgcgagaa gaacccggcc agcaccagcc cgatcacgcc
     2701 gggcggcagc agggacttcg ccagctcgac gtacgcctgc tcggggttgg tgaggcccgg
     2761 gacgatcagc ggcgcggcga acatcggcat gaacaggatc agcggccaga ccagccacag
     2821 cgcgctggac agcagcgccg accgcttcgc cgcggagccg gacggggcgg ccatgtaccg
     2881 ctgcgccagg ttccacatgc cgccgttgta ctcgaaggtc ttgatgaaca gcagcgccag
     2941 gaagaacgtc agggtgtacg gcccgtggaa cgggtcgccg tgcccggcgg gcaggtcgtc
     3001 ccacatgttc cacagcgcgg agacgccacc gaggtgcccc aggaaggcga ggaacatggc
     3061 caccccggcc acgccctgga tgacgaactg accgaagtcg gtcagcacgt cggcccagag
     3121 gccaccggcg gtgatgtaga ccagggtgac ggcgccggtg atcacgatgc cccacaggat
     3181 cggcacgccg gcgaagccgc gcagcagcac ggcgatggcc acccatttgg ccgcgatgtc
     3241 cacgaccttg agcagcgccc cgctgtaggc cagcacctgc tgtgtgggca cgttgtagcg
     3301 gcgagccagg tactccagcg gggaggccac cccgtgcctg gagcgcagcc ggttccaccg
     3361 ggcggcgaag aggaaggcgc cgatcccgac gccgaggccg atggtcaggg cccaccagac
     3421 gtacatcgcc agcccgtagg tgtaggcgac ggccgcgaac gcgacgaaca tgatggcgct
     3481 gtaaccggac atatggtgcg agatcccgga cagccaccag gggatcatgc cgcgggcggt
     3541 gaagtagtcg gcgacgctgt ggatccggcc cttggcccac aggccgatac cgagcatcac
     3601 caggaaatat ccgctgagta ccagccagtc gagcgtggtc acgtgccctc ctccggtgcg
     3661 tgacacgggt cacaggggac gttgcgtttc ctggatgttc tgctacatgg aacaccttgt
     3721 caatacatgg aacaaatcag atcggtctat ggacagactc ttgaccttgt tccgtgtcgc
     3781 gggacaatgt tcccttctat gggaaacagg agggtccatg cccaacatca ccgttgaact
     3841 gctgtccggc cgcacgctcg accagcggcg cgagttcgcc gaggcggtga ccgccgccgc
     3901 ggtcgacatc ctcaaggccc ggagggctgc ggtgcgcatc cgcttcgacg agatcgagcg
     3961 cgaggacgtc gccaacggcg gcaccctgga gtccgaccgg acctgagcac cgccggtggc
     4021 ggggcctccg gcggtgcggc ggccgggtcg acgccgggac gaccgaggtg gtccgtcccg
     4081 gccggtcgct gtcgcaatcc gtcccggccg gtcgctgtcg caatccgtcc cggccggtcg
     4141 ctgtcgcggt ccgtcccggc cggtcgctgt cgcggtccgt cccggccggt cgctgtcgcg
     4201 gtccgtcccg gccggtcgct gtcgcaatcc gtcccgggcg gtcgctgccg cggcctgtcg
     4261 ccggccggtc gctgccgcgg cctctgccgg cggtccgtgc cgcggtcgcg gccgggccgc
     4321 tgcccccggc gggcccggag tgaacagctg gaagccgtgc cgagggcttg tgtaatgtcc
     4381 ggatcatgcg atcgaccggt tcgggatcgc cgctcgtgga ggcggtcatc ttcgacatgg
     4441 acggcaccct gatcgagtcc accgacgtgg tcaccgccgc cttccgtgcg gccgtggtgg
     4501 ccggtggcgg cccggtcttc tcggacgccg acatcgtcgc cgcgtatccg ctcggaccgc
     4561 ctcggcggat cctggagcac ctgctcggcc gcccggtgac ttccggagaa ctcgatctct
     4621 actactcgca tctcgcgtcc ggccgggtgc ggacctacga cggcgtcgag cacgtcctgt
     4681 cgctgatcgc gcagcgggcc tccgtggcgg tcttcaccgg ggccagccgg aaggcggctc
     4741 agatcctcct gggcggcgcc gggcttctcg gattcttcgc ggtcgtggtc ggcggagacg
     4801 aagtcgccca ccccaagccc gagcccgacg gcatcctgct cgcctgtgac cggcttggcg
     4861 tcgagccggg ctcggtggcg tacgtcgggg actccccgct cgatctgcgg gccgcccggc
     4921 gggccggcgc gctggcggtc gcggcggcgt ggggccatct ctacgatgcc ggccaggccg
     4981 ccgaccgcac cgcgcgacag ccgatcgacc tgtgcgcgct ggtgtcgccg caggcgagcc
     5041 gggacaccgt tcttccggcg tagaagccgg tcccgtggtg atgcttcgcc cgcccgggtc
     5101 aggggatcgc tcccgcccgg gccgctgtcg tccggcgagg tgagcctcgc cgcttcacga
     5161 agacggaacg tggtgccgct ggccgccggc cggatcgccc gcggcggtcg gccgccgcgg
     5221 gccgggcccg aatgtccccg gccgcggttc gtgcaggcca acccttcgtc ggctgtgaga
     5281 tgaaccactt atggccccga cctgttaggt aggttaactg aaggggaaaa gcgaaccggc
     5341 agctgacgcg cccggcggat ggctgatcgg tctgtgcaac cgggcgatct gcccggttgc
     5401 acaggccgag acggagatca tccagaagga gtagaaccaa aggggtccgt gggacttagg
     5461 cgaatcgcga cgaagctcaa gctttgccgc ttttcgtccg ttcggcggtg ggagaggcgt
     5521 cgtagccggt ctggcctgga gtcgcgccgg tggctacatc atgcatacgt cacggggagc
     5581 ggtgcattgg acgacataac accgacctat ttcgctgagc tgaacggcgc gctgccggcg
     5641 gggaaagccg agctcgtgcc gatcgcgtcg ttgtcgtcgg catggacgcc tcgacagacc
     5701 gccctggacg agcggcacgt ccagctgttg gcgcagtcgg aagcgccgtt acctccgatc
     5761 ctggtgcaac ggtccaccat gcgggtcatc gacggggtgc acaggctgca cgcggcgcgg
     5821 cgcaacggtg ccgaggagat cctcgcccat ctgctcgaag acgacgaccg ggccgcttat
     5881 ctgcgcagcg tcgccagcaa cgtggcgcac ggcctgccgt tgacgctcgc cgagcgccgg
     5941 gccgcggcga agcggctgct ggaatggttc ccgcaatgtt cggaccgttc catcggtcgg
     6001 gtctccgggc tctccggcaa gaccgtcgcc gcgctgcgca agcggtccgg cacgggtatg
     6061 cctgccgaac ggatcgggcg ggacgggcgg gtgcggccgg cccggccggg agccgatcgg
     6121 ctgctggtgg aggagctgat cacccagcat ccacatgcct cgctacgcga tctcgcccgg
     6181 cgcgccggtg tctcgccgaa cacggtacgc aatgcccggc tgcgcatgat ccatcgaggg
     6241 cccggtaccg atcggccggc cggggcgccg ggcgcggagg gggctccggc cggccaggac
     6301 ttcgctcccg atgatgtcgt gctgaccaac ctgagccgag atccgtcgtt gcggtacacc
     6361 gagacgggac ggaccctgct gcggctcctt caccagcatc tcgggacgtc gctcgacggg
     6421 caggtggtgg agtcacttcc gccgcactgc ctgccgctgg tctccaaggt ggcccgcagc
     6481 gtggccatgc agtggaagca gttcgccgag atcgccgagg ggcgggcgaa cgcttcggct
     6541 ctctagcccg gcgccgggtc cgccggtcgc accgctcgga ccggtgggcg caccgttcgg
     6601 gccggtgggc gtgctcgcgc cggcgggtgt gtcccctccg tgaggcggct cccgtccgtg
     6661 ggggccgctg atcacgacgg cgccggtcgg gcggccgatg cggggtggcg ggtttccgcc
     6721 ccggcctttc tccggaatga cccggcggtc cgcagcggcg tgcaagtgcg gaaaatgcgc
     6781 ggtgcacatc cgtaccgcga tgaaaagcgt cgcgggccgg cacgagggtc gggtcgtcat
     6841 ccccggcatg gccagcggca atgtccgcgg taaaaatttt gcgcgtgtcc ggcaattatg
     6901 tcgatcggca aacgtctttc tccggcgatg accgcaacgg cgtcggcgtg ctagttttcc
     6961 ccgtggcggc cgatggttag aggcggccct cggcagtgcc gctcgatatg acaatgcgag
     7021 agcggcgagc tgccgccgtc agcgcggtat ggcgctgagg agccatttcg gcgtcggtgg
     7081 aggcgcagcc gtgagctgcc gcgccgaagg cacacggtcc gcgtcccctg aaggaggtgc
     7141 attgtgcgtc taggaatagc tcgcacgctc gccggctgcg tcgtcgcggg agccgacgac
     7201 ggcgcagaag attactgccc gccatattgg cggtcgagcg agccgttgtt tcgccgagcc
     7261 cacgacgtgg tggccgcggt ggcggcccgg tatgccccgg tggcctcggg gctggccggc
     7321 gtcgtgtccg ggggccggcc ggcggccggc tacccgcccc tggtggaggc gctcgaacgg
     7381 tacgcacggg agcccggatg gagccgggag caccgggacc tggccgcctc gatcgagcgg
     7441 tccgtgcggc tgctgtattt cgagggtgct ccggaaccgg cggtgcggcc ggcgccggac
     7501 cggctcgccc cggcgggcgc cctgccggcc ctgcacgtcg tcattccgtt ccgggcgccg
     7561 cggggcagcc tgcgcgagcg caatctgcga gcctgcctgc gatcgctggc gcaacaggcg
     7621 tcggggtcct ccggcttcta tgtcaccgtg gtcgagagcg acgatcggcc gcggcattcc
     7681 tgggtcggat cctgggccga caattacgtt ttcgaaccgc agagcggccc tttcaacaag
     7741 tcatcgtcgg tcaattttgg tgcgcggcgg tcacgttctc cgcgggacgt gatatgcgag
     7801 ttggacgcgg atatggtcgt cgacccctgg ttcatcacca gggtgcgtgt gcaggccgcg
     7861 gtatcacccg cctttctgcc ctatgaagac gtccactgcc tcgatccgga aagctcggcg
     7921 cggctggtct cggaacgcac ggcgggcgcg ggaacagtgg ccggttacct gttgcgccgg
     7981 ccgccgggag gttgtgtggt cgtcaccgcc gaactgttcc gcgcggtgga cggattcgac
     8041 acgtccttca ccggttgggg tggcgaggac agagacttcg tcgaccgcct gtcggcgttc
     8101 tccccggtgg cgcggtcggc ggccacgatg atccatctca atcatgaacg accgtccatg
     8161 aaccgggcgg cccagttcgc taccggagac cgcgaggcgg tcacccagga ggtgggctga
     8221 cgtgcccgag ctggcgcagc accaggacct cgtcgtcaca cgggccgccg gcttcgccga
     8281 cctggcggag caggtcagtg cccgggtggt cgagcacatc gatcgggtcc tgaggcaaca
     8341 cgagttctgt accgtcgccc tgaccggtgg cagcaccccg gcggccacct accgctcgct
     8401 gagcgctgcc gacctgccat gggaccggat ccatgtcctg cagaccgatg accacatcgt
     8461 cgccgacagc gagacggggc cgtcctggag cgtgatcgag cgggatctcc tgcaccggtg
     8521 cgcggtgccg gtcgccaacc ggcatcccat gccggtccgg accggacccg gcctggcctc
     8581 ggcggtgcgc cgctacgaca tgcagatccg cagtctgctc cgcggacaga gcccggacgt
     8641 cgtggtcctg ggactgggcg aggacggtca cacggcatcg atcttcgacg gggacccgag
     8701 cgccctgacc gccgaccggg tggtggtgac caccgccccc tatcacggtg tcacccggat
     8761 gaccctcacc ctgcccaccc tggcgcgggg cggcctgaga gtggtcctgg cctgcggaac
     8821 cgccaaggcc gccgcggtgg ccgggctgct cggcgagggc gcgccgagaa cctcggcggt
     8881 ggcgggcatc ctgcgcggtg gcggaatgct cttcgtggac gacgccgcga tgtccgtcgc
     8941 cgatgcggcg accggctagg cggcgggcgg catggatccg atcctctgcc tggatctggg
     9001 cggcacgtgg ttccgcgccg gcatcctcgg cgccgacggc cggctccggc tggtacgcaa
     9061 gacgccggct ctgtcggtcc gcaaccaccg tgagccggtg gcgaagctgc agcagcgcct
     9121 cgtcgaccac atcgtcacgg ccacgctcga agcggacgcg gcgtgcggcg tcgcaacggt
     9181 cggcatctca ctcggcgcgg cgttgaacgg ccgcaccggg gaggtcttcg gcagcgcgcc
     9241 gctgtggggc cccggacggc acccgatgcc gttgaccgac ctgctggccc ggcggttgcc
     9301 ggacgtacgg ttcgggctgc tgaacgacgt gaccgccctc gcccacgccg tccgggcgag
     9361 atgggcggcc acccggcccg gccggagagc ggcggcggtg acggtcagca gcggtatcgc
     9421 gtaccgcacc atcgtgctgg agtccggccg gatccccctg gagccgcggt acggcctgca
     9481 gggcgagatc ggccatctcc cggtcgacgt cgagtggcgc ggcagcgtcc tgcgcggccg
     9541 ctgtgactgc ggcggggaga accacctcag cgcgttctcc tcgggccgcg gactcgaacg
     9601 cctgctcgcc acgctgcccg aggcgagggc gttccgtgag ctgcccggcc agccggtggc
     9661 gacgttctcc cggcgcgtcg ccggcgccga cccggcggcc ctggaaatcc tcgacctgtt
     9721 cacccgcccg ctggcgaagg tcctgctcta ccaggcgact ctcgaccccg aggtcggagc
     9781 caccgtcctg ttcggtggcg tcgtcgaagc gctcggcgcc cactacctgg aaagcctcgt
     9841 acgaaatctg gaggaactcg gactgtatgg catcagcgat cgtgacccgc agtatttccg
     9901 cacccggata caccttggcg acgacgacgg cttggccgcc atgcgcggcg tggggtcgta
     9961 cctgcgagac cgcctccacc gcaacgactg aggagatgcc atgaacggct ggacggtacg
    10021 ctgccggcaa gacgtcacct accgcatcaa cgctgtcgtc gacgtcttct ccccggccaa
    10081 cgaggcgctc gccgaagccg ccgatgtggc cgacgggaag aggtacctcg tcgtggtcga
    10141 ccggacggtc gactccctct acggcgaccg gatcgaccgc tacttcggtg cccgcggcgc
    10201 gcgcaccgtc aaatacaccc tcggcccggg ggagcgggtc aagaccgcgg actccctgct
    10261 cgacatcgcc cgcacggccg accaggccgg gatcaggcgg cgctgcgaac cgatcatcgc
    10321 cgtcggcggc ggcgtggtga cggatctcgc cggcatggcg gcgagcctct atcggcgtgg
    10381 cacgccgttc atccgtgtcc cgaccacgct ggtcggcctg gtggacgcgg ccatcggtgc
    10441 caagacggcg atcaaccaca acggtcacaa gaaccggttg ggaacctatt tcccggcggc
    10501 acacaccctc ctggacccga cgttcctgcg cactctgccg gcccggcacg tccggaacgg
    10561 tatggccgag atcgtgaaga tcgcggtgat gaaggacgcc accctgttcg cgctcctcga
    10621 ggcggactcc gccgacctgg tggaatcgcg catcgcgacg gcccacggta cggagatcat
    10681 cgagcgcagc gtcaccgcga tgctcggtga gctggaggcg aacctgtggg agcacgagct
    10741 gcggagggtg gccgacttcg gccacacgtt cagcccgcag ctcgagatgt gtgccggtga
    10801 cctgctgcac ggcgaggcgg tcgcgatcga catggcgctg tgctgtgcca tcgcgcacct
    10861 gcggggcctg ctcagcgatg acgcgctgcg ccgggtcttc gccctgctgc agggcctggg
    10921 gctgcccacc gagcacgagg cgtgcacctc acggatgctg ctgggcgcgt tggccgacac
    10981 cgttcggcac cgggacggcc accagcacct tccgttgccg accgggatcg gcagcgccgt
    11041 cttcgtcgag gacgtcacgc cggcggagat cgccgcggcc cgcgatacgg tgagacgtct
    11101 ccagccgatc gcggcgaacc ggtgacgggc cgggacgatc tgcgggtgct gcgcgccggc
    11161 atctgtggca ccgatctgca gattttccgc cgggtgcgcc cggaccgcgc cggcatcctc
    11221 ggtcacgaag gcgtggcgga gcgcgcggcc accgcggacg gccggcgccg cttcgtggtc
    11281 ttcaacccgg tcgatccgga cgaccaggac agcatcctgg ggcacagcta tgacggcatc
    11341 ttccgtcgtc acgtcccggg cggcgcggaa cggatgccgc ggacggtgcc ggtcgatccg
    11401 cggttgccgg cggatctcgc cgccctggtc gagccgctgg gcacggtgct ctacggctgg
    11461 gagctcgcgt cgtccgccgc gccgttgcgc agcgtatcgg tgtggggcgg cggcacctcg
    11521 gcgttgctgg tcgccatcgt ggcacagctg cacggctgcg acgtcgagct cgtccaccgc
    11581 cgcggcgagc gcctgcgctt catcgacggg ctcggggtgc tcgacggggc ccggctgcga
    11641 ctgcccggcg cggccccggc cgtggccggc tgtgacggcg cgttcctctg cctgccgcgt
    11701 gagggcgccg cggccgggct cacccaggcg gtggaccagg tgcgcccggg tgggtgcatc
    11761 gacctgttcg gcggcttcgg gcccggcgac cggcatccgg ccaccgggag gctcgacctc
    11821 ggcatggtac ggcgtgccaa cgtgtgcggc cgtccggtgg gatccgccac cgccgaggtc
    11881 cgtaccccgg ccggcaagcc ggtgtcgctc accggccatc gaggaacggc ggagcggcat
    11941 ctgacccggg ccgcggagct gttgcgcacg cacgcgagcc ggttcggcgc cctgatcacg
    12001 cacgtcgtcc cgctggccga ggccggcagc tacctgtccg cgatggcgtc cggatcacgc
    12061 gcgccggcgc cgccgtacga atacgtcaag gtggtcatcg acatgacgct ggtatcggcc
    12121 ggcaccagag gtcccgacct gtcgacgcgg ctcgccgacc tgccggtgga gtgcccggta
    12181 tgaacggggt cgcataccgg cgcatcgggc accgcgacgg tgtggcgtac ctggaacgcg
    12241 cgcgcaccgg ccggttgacc gaccagccgg cgcgggtggt gatcgcgccg ctcgtcgtcg
    12301 gcgtctgccg gtcggacctg cgcgagctgg acgggacacg gcatctgcgc cgcgacttcg
    12361 ggcacgagat cgtcgccgag gtgcggtatt ccaccctggc ggacaccctg cccgtcggcc
    12421 ggcgtgtcgt gctcgatccc catccggtgg tgcggcggac gtcgggcttc gccgatctcg
    12481 tggagatcga gggtacggtc gccgatgtcg cggcggcgct gcggccggtc cccgccgaca
    12541 gcgaccccct ggcggccctg ttcaccgaac cgctcgcctg cgcggcacat tgcctggccc
    12601 gggtcgatgc ggtcatcgcc gcgacggccc atgcccggcc gtccccggtc gccgtcgtcg
    12661 gagcgggcat cgccggcacc ctgatggccg ggatcctgcg gtcgcgcggc accgaggtgc
    12721 acctggtcaa ccggggcggg cagcgcctgc ggttcctggc ggaacgcgac gtcctccccg
    12781 gcgtcgacct gcacccggcc gaccggccgg gccgtggcgg gttcgcgtgc gtggtgctgg
    12841 ccaccgccgc ggcgaccggc gccgcgctgg agctcgcggc cggcctgacc ggggacgacg
    12901 gagtcctgat gatctatgcg ggcacggagc cgggcagccg gttcctgggg caggacatcg
    12961 acgcgatccg ccgcggtgaa gggcgggtga ccgtgcacga cggccgcagg aggatgcacc
    13021 tggccgggtc gcacggcgcc accgccgcgg acttcgccgt cgccacccgg ctgctccagg
    13081 accggcgcga ggggccggcg ctgcggcgca cggtccgccg cctgatcgat gtcgaagcgc
    13141 cgctggacga gggcccggcg ctgctgcggg agatggtcag ccgtccctac gtcggcaagg
    13201 ccgtgctgac gcccggggtt cccgatcgtg gatgaaggag gaacgatgaa gatcgccaaa
    13261 taccattacg ccgcccagtt ccggcacctg ccgcgggtcg tccgggccat cgacgacctg
    13321 ctggtgcgcg gcgactacgt cctgggaccg cacgtcgagc agttcgagca ggacttcgcc
    13381 gactacatcg gcgtggagca cgcggtcggg gtcaactcgg gtaccgacgc gctggtgctg
    13441 gcgctgcgcg cgctgggtgt cggacccggt gacgaggtgg tcacggtcgc caacacgttc
    13501 cacgcgacgg tgctggccat caccacggtg ggggcccgcc cggtgctggt ggactgcacg
    13561 ccgcacgact acctgatgga cctggagcag gtcgaggcgg cgatcaccgg ccgcacccgg
    13621 gccatcatcg cggtccacct gttcggcaag gccctcgaca tggcggcggt gaccgccatc
    13681 gccgagcggc acgggctcgc cgtggtcgag gactgcgccc aggcggtggg cgcgtcgtgg
    13741 cagggcaggc gggtgggctc gtggggtgac atcggctgct tcagcttcca cccctcgaag
    13801 aacctggccg cggccggcga cgcaggcgcg gtgaccaccg accgcgcgga cctggcgcgg
    13861 accatccgca cgctgcgggg cctcgggcag gccgcgcaga acgatcacgt cgcgttgggc
    13921 tgcaactcga agctggacgc gatccaggcg atcgtgctca gtcacaagct gccggagctg
    13981 gacgggtgga acgccggtcg ccgagcggtg gcgggccggt acagccgcgc gctggccggc
    14041 atcgcccggg tgcccgagcc ggccgggcgc gagcatgtct tccacctcta ccaggtcggg
    14101 gtcgagcagc gggacgaggt tctcgccgag ctggtcggcg cggggatcga cgcggtggtg
    14161 cggtaccccg taccgatcca ccggcagccg gctttcgcgc acctcgacct gccgagccgg
    14221 ttcccgcacg ccgactggca ggccgcgcac acgctgtgcc tgccggtgcg gccggacctg
    14281 accgggaccg agatcgacta catcgtcgac caggtcacgt ccgccgtggc gaagcggacg
    14341 ggggcgtgac cgtggtcgag gttcttccgg cgctgctcgg cgccgacccg ctggccctcg
    14401 gtgcggcgac cgacagcctc gtcggcgctc cggtgcgata cctgcacctc gacgtcatgg
    14461 acggcgcatt cgtccccgac atcagcttcg gcgcccgtac ggtgaccgcc gtgcggcggc
    14521 gtaccgagct gccgctggac gtccatcttc aggtggcgaa cccggaggcg cacctggatg
    14581 ccctgctcgc ggcgaaggtg gatctggtca ccgtgcatgt cgagtcgacc gcccacgtcg
    14641 cgcggctgct gcgccggctg cggctggccg gggtggacgc ggcgctggcc gtcaaccccg
    14701 gcaccccgct cggatccctc gccgagctgc tcggcgagat cgtccaggtg accgtcatga
    14761 ccagcaatcc gggcaccagt gacttcctgg agtacaccct ggacaagatc cgccggctca
    14821 gggcgctgct ggcggagagc cgtctggagc acgtccacat cgccgccgac ggcggggtga
    14881 ccgaggcccg ggccagggcg ttgcacgagg ccggcgcgga ccgcctgatc gccggttcgg
    14941 cggtcttcca ggcgcccggt ggcgtcgtcg acggtgtggc gcggctgcgc gaggcggccc
    15001 tgtcatgacc ggggtgcatg cccgtggcct gctgttcgac ctggacgggg tgctggtgga
    15061 cagctcggcg gcgatccgcc gggcatggtg ggagtgggcc ggcgccaaag ggctcgatcc
    15121 ggctaccacg ttcgccgccg ggcacggccg tcagacgatg gatcacatcc gggcggtggc
    15181 gccccacctc gccgtgccgg ccgaggaacg gcgcatcgac gagctggagg cgaggtacgc
    15241 cgacgccgtc gagccgcagc cgggcgccgg cccgctggtg gcgagcctcg ccgaggtgcc
    15301 ctggggcgtc gtgacgtcct gttcggcgca ggctgcgaga acccggctgg agcgggccgg
    15361 tatcggcgtg ccgccggtgc tggtgcacgc cggtgatgtc ggacgcggca aaccgcaccc
    15421 cgacggctac ctgcgcggcg ccgaactgat cggggtcgat ccggccgagg tggtggtgtt
    15481 cgaggacgcg ccctccggta tcgaggcggc cgtcgccgcc gggatgaggg tggccggggt
    15541 gtgcaccacg catgatccgc atcagctggc cggggccgca tggctcgtcg aggacctcag
    15601 cacggtccgg gtcacgcggt ccgtcgactc cgccaccctg cttgtccacc tgagagagtg
    15661 cgatgctgcg cgtcggtgag gtctccgcgg actacgtccg cttcacgagg tccgcgctca
    15721 agctgcacta cgggatcgac ctgccggaga ccgccgtggc ggcgaaggcc gccctggccc
    15781 ggccgggcgg tttcctgacc atcggcgatc ccggcgtgat cggcgcggcg gcgatcttcc
    15841 cgttcgacat gaccgtcgct cccggtgaga cgctgccggt cagcgggatc ggggatgtcg
    15901 ccgtgtcgcc caaccaccgc cggcgcggct ggctggcggc gctgatgcgc gagcacctgc
    15961 gatccgcggc ggagcacggc gacgcgctca ccgtgctgac ggcgagcgag gcggccatct
    16021 acggccggtt cggctatgcg ccggtgaccg aggcggcgag ctggtcgctg cataccgagg
    16081 ggctggagct acgcagccgg ccggtcaccg gagccgtgga gctgctcgac gatccgagcg
    16141 ccgccaccgc ggtgccggag gccttctcgg cgtaccagcg tggggcgccg ggagagctgg
    16201 ctcgcagcgc ccggtggtgg acgacgcgct ggaacgatcc cgtggcggtg ggcgcgccgg
    16261 ccgacacgtt cgtcgccctg taccgcgacg gccagggccg gcccaccgga tacgccacct
    16321 ggtcgcgcgg cgggccgtgg acgccgtacc acgggcccgg ggtcgtcgag gtcgacgagt
    16381 tcgtcgcggc cggcccggag gcggcgtacg cgctgctggc gttcctgcgg tcactggacc
    16441 tgtgccggga gatcgtcttc cggaaacgcc cggtgggcga gccgttgcgc gagcatctcg
    16501 ccgacatccg gagactgcgg atggccgagc gcgtcgacaa gctgtgggcc cgggtggccg
    16561 acgtgccccg ggtggtgcgg gcctgtacgg ccgggatcga ccgggtggtg acgatcgccg
    16621 tgcacgatcc gggcacgggt agcaccggac gctacacgct gacgccggac ggcgaccgcg
    16681 tcgcctgccg gcccggtgct cacgcgccgg acctgaccct gagctcggct gatctcaccg
    16741 cctgcctgct gggcgcggtg tccatcgtcg agctggcccg ccgcggccgg atcgacggcg
    16801 gggatcgcgg cgcgctgctc gcggtggcgc gcgccctggc cggtcagacc acgccgcact
    16861 gttcgaccgg cttctgacgc cggtgatctt cacgcggaag gatgtcccac gctttgatca
    16921 tctctacgaa cacccgggtg tgcctggccg gggaggacct cgactggctg gggtaccgat
    16981 cggtctgcgt agccgtcgat ctgcccacca ggatcgcgat acgtccggac tgcgccgacg
    17041 agagcggcgg cgtcacccgt acggcgaacg cggtatggca gttcctgcgg cagcgtgtcg
    17101 agcgcgtgcc ggcccgccgg cccggcgtcg tggtcgacgc cgacgcgccc ctggcgagcg
    17161 ggctgtcgtc gtcctcgtcc ctgatcatcg ggctgttccg cgccttcgcc ggacacctcg
    17221 acctgccgct cggcgacgag acgctgctgt cctggtcctt cgacttcgag tacgcgatct
    17281 gccacggcgg cggcatggac cagaccgcca tcatccgggg tgacacggtc ctgaccgccg
    17341 ggcgggacgg tacgccacca ctgctgctgg gacacgcccg gttcccggcc gactggcgcc
    17401 tgatcgtcgt cgactccgcc atgccgaagt ccaccgtcgg tcacctcgcc gaggcccgcc
    17461 gccggcatgc cgagggcgac agccggctgt cccggtacat cgcccacgct gatcgagccg
    17521 ccgcctccgc ctgggatgcc gttctggccg aggatctccc ggcgctggtg gcggccatgg
    17581 agcgcgcgca ccgggcgatg cgcgaggtcg ggatgtccag cgcggtgctg gaggacctgc
    17641 gggccatcgc ccgagccgag gccggcatct ccctgaagat caccggcgcc ggtggtggcg
    17701 gtgccatgat cggcgtctgc cgggacgtcg acgcggtgag cgtcgcaacc cgcctgcggg
    17761 cggcggccgg cgccaggtac gccggatcca gcgtgctgat cgcgcgtgcc gcggccgggc
    17821 cggcggtgct ctcggccgct tccgagtcca ccgtggcggg ctgaccgtgc cgactcccga
    17881 tttcatcctg gaactgcgca agagcatagg taccgcaccg ctctggctgt ccggcgtcac
    17941 cgcggtggtg ctgcacgagg gccggatcct gctgaaccgc cgctccgaca acggccggtg
    18001 ggcgttgctg cacgggatcc tggagccggg ggagcagccc ggtgtcgccg tcgtccgcga
    18061 ggtcttcgag gagaccggcg tgacggtatc ggtggagcgg ctgtcgagtg tcttctcgct
    18121 gccgcccggt gtctgtgcca acggcgaccg ggtgcagttc ctggacctga ccttcgtgtg
    18181 ccggctggtc ggcggcgagg cgcgggtcaa cgacgacgag tcgctggccg tcgcgtggtt
    18241 ccacctcgac acgctgcccc cgatggccga ggccgaccgg ttcctgctgg acaaggccct
    18301 ggcggcagag gcgtcaccgt ggttcgtgac cgatcccggc gacctaccgt gaccagccgc
    18361 cgccgagccc gcgacgatac gagaggtgcc cgccatggtc tcctggcgac cggcggcggt
    18421 tctgccggtg atgcccagcc ggggcttgcg ccggctcatg ctgtcggttc tggtggacac
    18481 cgccggggcc ggcctgttcc tgccgctgag cctgttgttc ctggtcgagg tcagagccat
    18541 cgcgccggcc gtcgcgggga ccgccgtgac cgccggttcc ctggtgtcct tcctggtgat
    18601 tccggtcgcg gcccgcctga tccagcgata cggcgcacgc cactgcctga tggccagcaa
    18661 cgtgctgacc gccgggggct acggcctcta cttcgtcgct gacggattcg gctcggtgct
    18721 gggcgcggcg ctgctggtga tgagcgccga ccggctgtac ggggcggcct ggccgacggc
    18781 gttggcacgc gtggcggacg gcgaggagct gacgcggtgg ttctcgttcg tcaatttcgt
    18841 gaagaccgcg tgtctgggaa cgggcgcggt cgccgccacc ggcctgctcg ccgtggccgg
    18901 gcgctccggc ctgtcggtgg cgctcgccgt caacgcgatc agctcggtgg tggccgcggc
    18961 ggtgctggtc ggcgtcgcgc tgccggagcg tggagcggac ccggccggtt ccggcggcgg
    19021 ccggtcctcg gtgtggtcgg cgctgcgcga tcagcgcttc cgctccctgg tgctctccca
    19081 gaccctgctc tcgttcgcgt ggctcatccc caccatcgcc tttcccgtct acctggtcag
    19141 cgtgctcggg ctgcccgcct actggccgac cctggtggtg acggcccggt acgccggcat
    19201 cgcggtgctg cagatgccgt tgagccggct gaccgcgcga tccacccgtg cccgggtgct
    19261 ggccggcgcc atcgcactgg ccgggtgcgc ggtcgccgtg accgccgcga tcccgctcct
    19321 gcccgccgcg tgcaccggag ccgcggcggt gctggtggcc gcccttctcg cggtggccga
    19381 gctgacctcc aaaccgaccg ccgcggcggc tgcggtacgg ctggcgccgc ccggtgacga
    19441 gggaccgtac atggcggtct tccagctcac gtggacggtg tcgtacgcgg tcgggcccgc
    19501 gatcatcggg atcggcctgg gccgcccgct gctgctctgg atcggcatcg ggctggcggt
    19561 gctcggcagc ggcgtggcgc acctgcacgg ccgggcccgg gtccgtacct gagcttcccc
    19621 cgcgcctcgg cggacccgga ttgcgccggg ccgtcgcaca tcgtcggagt ttcctgtctg
    19681 gagaggaacg cattttgctg tcgcatgacg gatacctgca tcgtgccgcc tcgcaccggc
    19741 cgtacttcag ccgcgacggt gacacctacc tggccgagac accgctgcgc gacctccgca
    19801 aggcgcacca gctgagggtg ctctcggagg aggacttcgc gttctggcag acctacggat
    19861 acatcgtcgt gcgcgaggcc gtcccgtcgg agcacgcgcg ccggctgctc gcgttcgcgt
    19921 tcgcgttcca ggggctcgac ccggaccgcc cgcagacctg gtacccggag cgggagtacg
    19981 cctcggagct ggagcgcgac ctgtacatct acgggttcgt cgaggcctac cagcatcagc
    20041 tcatctggga cagccggcag tcgcagcggg tctacgacgc cttcgtcgac gtgtgggacg
    20101 tcccggagtt gtgggtgacc ctggaccggc tgaacatcaa tcctccgaac gtcggcaacc
    20161 gggaccgggc actcatcccg gcgaccgatc gcggcttcga catcgacctg cactgggacg
    20221 tcgacacgac cttgccggtc atgccgcaac gggtgcaggg cctcatcgcc ctcaacgaca
    20281 cccggccgga gctgggcggc ttccagtgct cgccggagct gttccggcgc ttcgaccagt
    20341 ggcgcgtcca gcagcccgcc gaccgcgatc cggtgcgccc ggacgtggac cggtcggagt
    20401 tcccggtgat ccagcccgag ctccgggccg gtgatctgct catctggaac ggccaggtcg
    20461 cgcacggcgt gctgccgaac cggtcccggg acggcgtgcg cgcggtccag tacctgtcga
    20521 tgatgccggc gctgccggga caccgggagt tggtgcgctc gcgcatccgt tcctggcggg
    20581 agctgagcac ccccgagtgg aacgccacgc tgatcggcga cccgatccgg cacgaatccc
    20641 agcggtacgg tccggcgaag ctcaccgatc tgggcgaacg gctgctgggc tgcacaccgt
    20701 gggacacggt ggccgggtcc gggccgcggg agcggtgagc cgcgacatgc gccgcatctg
    20761 tctggccctg cccacgcacc gctcgtgcgg cccggtgatc agcgccgtgg cggcggaagc
    20821 ggcccacgcc gcccggacgt tcgccgtcga ggtgaccatg ctcgtcctcg actccgccga
    20881 tccggtggcg tacgccgggc atgccgcggt gatcgcggca ctgccggcgg cgcccggcgt
    20941 ccacgtcgtc cacctggacg aggcggcgca gcagcgcttc ctgtcccgtg tgaccgtggc
    21001 ggccgaggtg acgaagcccg atctggtcaa cgccctgatg ctgccggacg gggtgtcgta
    21061 cggcgcctgc acgaaccggg ccttcctgat cgccgccgcc ctcggatgcg agtccgtgca
    21121 ccggc
//
