LOCUS       NZ_CP023865            22030 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes teichomyceticus ATCC 31121 chromosome, complete genome.
ACCESSION   NZ_CP023865
VERSION     NZ_CP023865.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes teichomyceticus ATCC 31121
  ORGANISM  Actinoplanes teichomyceticus ATCC 31121
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Complete genome sequence of Actinoplanes teichomyceticus ATCC 31121,
            type strain of Actinoplanes teichomyceticus and producer of
            teicoplanin, isolated from soil near Nimodi, India
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8287152)
  AUTHORS   Yushchuk,O., Horbal,L., Fedorenko,V., Ostash,B., Luzhetskyy,A.,
            Kalinowski,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2017) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.5
            Genome Coverage                   :: 184.1x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003711105.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:18:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,294
            CDSs (total)                      :: 7,220
            Genes (coding)                    :: 7,116
            CDSs (with protein)               :: 7,116
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 27 of 104
            Pseudo Genes (incomplete)         :: 92 of 104
            Pseudo Genes (internal stop)      :: 11 of 104
            Pseudo Genes (multiple problems)  :: 22 of 104
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 156755
            Orig. end                         :: 178785
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22030
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22030
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22030
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12030]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12030
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(511..1152)
                     /locus_tag="ACTEI_RS00690"
     CDS             complement(511..1152)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787705.1"
                     /locus_tag="ACTEI_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_122975859.1"
                     /transl_table=11
                     /translation="MRIVIAEDSVLLRAGLTKLLADGGFDVVDAVADAEQLLRAVAEHR
                     PDLALIDVRMPPTHTDEGIRAALVIRHQFPAVAVLVLSQYVEERYATDLLSVRTSGVGY
                     LLKDRVAQVSDFLAALHRVAAGGTALDPEVVAQLLVRHRQDPMDRLTPRELEVLRLMAE
                     GRSNHGIVDTLKVSHSAVEKYITSILSKLDLPPTDADHRRVLAVLRFLRI"
     gene            complement(1140..2351)
                     /locus_tag="ACTEI_RS00695"
     CDS             complement(1140..2351)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014445010.1"
                     /locus_tag="ACTEI_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_122975860.1"
                     /transl_table=11
                     /translation="MTSVETAVPRRAGALRTVLSGLWSARTWRATLHALAGLPLGVAAF
                     ALTCGLPVGAGYSAIWSLLYASGDDLALTTLFVVLTVTATLSLPRVVRGLSAVQRRRFR
                     ALLDVEIPPSHGWWRQFGYHVLSLFIGVSGAAAVAVCWSATLLAWAEPAYLVLAAPALV
                     AAPWVARVVARADTAAARALLGPSRNEELSVRVETLSRSRAEVVAATDAERRRIERDLH
                     DGAQQRLVSLAMNLGMARANLTDLPAPARQAIVEAHDEATQALAELREFVRGLHPAVLD
                     DRGLDAALSGIAARAPVPVRVAVSVPDRCSPVVEAVAYFVVSEALTNIARHAHASRAEV
                     TVDRVADRLRVVVTDDGRGGATPGGGTGLHGLAQRAASVDGTFALHSPAGGPTTVTVEL
                     PCGS"
     gene            2511..3713
                     /locus_tag="ACTEI_RS00700"
     CDS             2511..3713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014445011.1"
                     /locus_tag="ACTEI_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrolase"
                     /protein_id="WP_122975861.1"
                     /transl_table=11
                     /translation="MPGLAPALTRRSLLSAAVLTAGLGVITRAPAAARPRSAAEGYTLP
                     MPTGPEQLGTVALHLVDRTRTDPWVPGRPVREIMIQIWYPARHIHGHPAAPWLSPGAVP
                     HFSEMFGLPAERVRATATHGRAGAPVHGGRPVVLYSPGLGGDRGTSTVLAEELVSHGYI
                     VVTIDHTHDASEVEFPDGRVEVAAIPPDIDEQIIAQVVAVREADTRFVLDQLAVVNAGG
                     NPDAGNRRLPIGLRGAFDLNRIGMFGHSLGGSTAAATMHHDRRIKAGVNLDGTLVGAAA
                     VAGSDRPFLLLSSDHGTDPEDPTWDAFWTSQRGWKRELSLTGSVHGSFNDGQVLYPQAA
                     PEIGLTPEQLAGMVGTLRPQRSVTIQRDYLRAFFDQHLRGRRSRLMCGADPRYPEIRFV
                     R"
     gene            complement(3720..4121)
                     /locus_tag="ACTEI_RS00705"
     CDS             complement(3720..4121)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_122975862.1"
                     /transl_table=11
                     /translation="MVEDHRRGGRGAQPLRQLTGAVGVQDADERQAQRPRRLGEHGGGG
                     DDVGRVGLQGALDVPATGKSSRPGRSCSSRWTPPACRVTCPPIATPRPGPLVACAVACL
                     NAAMRAWPAGDGAGSRDALLARAMNAPLG"
     gene            complement(4222..4476)
                     /locus_tag="ACTEI_RS00710"
     CDS             complement(4222..4476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014440263.1"
                     /locus_tag="ACTEI_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_122975863.1"
                     /transl_table=11
                     /translation="MSEPQEVVQTRGDDRVDLMTSDANGDGRTDVWVSDTDGDGKPDLF
                     QFDTDGDGKVDLTMVDLDEDGTPDTIVDGDGGLPPAAAG"
     misc_feature    complement(4530..4544)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.81"
                     /tool="antismash"
     gene            4716..5066
                     /locus_tag="ACTEI_RS00715"
     CDS             4716..5066
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015618224.1"
                     /locus_tag="ACTEI_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hotdog fold thioesterase"
                     /protein_id="WP_122981844.1"
                     /transl_table=11
                     /translation="MGIVITEATAERVVGTMPVEGNTQPYGLLHGGASCVLAETLGSVG
                     AVLHGQTVDRPFAVGVDINATHHKAARSGLVTGTAVPVHRGRAVATYEVVLEDEAGDRV
                     CTARITCLLRGA"
     gene            5118..5507
                     /locus_tag="ACTEI_RS00720"
     CDS             5118..5507
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014440261.1"
                     /locus_tag="ACTEI_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_122975864.1"
                     /transl_table=11
                     /translation="MTGVPQHAFDDATQILTCAFSGDSEAVASTFDAVVDRDGVVGAWD
                     VAWCLAATMVGDLPGGGGWTLDFPGIDDARYDKRWVARFVSAYVNGDFPTGEALFGAAI
                     ADGQLPECLLALAGSTVATLRHRAA"
     gene            complement(5541..5849)
                     /locus_tag="ACTEI_RS00725"
     CDS             complement(5541..5849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020516914.1"
                     /locus_tag="ACTEI_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_122975865.1"
                     /transl_table=11
                     /translation="MHTFTNEAEQTAYNLAEALSEKAMSYMRNAEEAAEAFRTGQTAMR
                     RQFKARGLSEAEADIRYSGTAQASRAIADNSFFMSLASMYNTAAATQYAKALYHKKS"
     gene            complement(6146..6286)
                     /locus_tag="ACTEI_RS36650"
     CDS             complement(6146..6286)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTEI_RS36650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164465805.1"
                     /transl_table=11
                     /translation="MDAGIIGPVLLGLLGIAVLYRVIRLAVAHGIADAEDRRRRETGRE
                     H"
     misc_feature    6296..6314
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.38"
                     /tool="antismash"
     misc_feature    6396..6411
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     tRNA            complement(6597..6670)
                     /anticodon=(pos:complement(163389..163391),aa:Phe,seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="ACTEI_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Phe"
     gene            complement(6597..6670)
                     /locus_tag="ACTEI_RS00730"
     tRNA            complement(6684..6757)
                     /anticodon=(pos:complement(163476..163478),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="ACTEI_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asp"
     gene            complement(6684..6757)
                     /locus_tag="ACTEI_RS00735"
     tRNA            complement(6810..6882)
                     /anticodon=(pos:complement(163601..163603),aa:Glu,seq:ttc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="ACTEI_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Glu"
     gene            complement(6810..6882)
                     /locus_tag="ACTEI_RS00740"
     gene            complement(7056..7934)
                     /locus_tag="ACTEI_RS00745"
     CDS             complement(7056..7934)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018255064.1"
                     /locus_tag="ACTEI_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_122975866.1"
                     /transl_table=11
                     /translation="MADEALSAGAAARRLGVAVTTLRTWHQRYGLGPSRHEPGHHRRYT
                     AEDMDRLLIMQRLTAQGVAPAEAAAWARNAPSAGPGDQPAPPAAQTAASSGEGTVRGLT
                     RAAMRLDAAAMRDILCAAVKERGVVPAWTEVMIPVLTAIGDRYQSTLRFVEVEHLLSRT
                     VTEVLAAAQRAPGTPRVLLSAADEEQHTLPLEALAAALADAGVPSRLLGARVPPQALLD
                     AIGRTGPAAVVLWSQCAATGSVDQLTRVRDAPHPPLVVAAAGPGWPGDELPPGITRLTG
                     LAEAVQLLASV"
     gene            complement(7924..8484)
                     /gene="idi"
                     /locus_tag="ACTEI_RS00750"
     CDS             complement(7924..8484)
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015618240.1"
                     /locus_tag="ACTEI_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_122975867.1"
                     /transl_table=11
                     /translation="MSAQVFNPREEHLVELVDVQGQPVGSATVSDAHRAPGRLHRAFSV
                     FLRDAEGRVLLQQRAAVKTRFPLRWGNTCCGHPEPGEKVTVAAGRRLVEELGVRDIPLT
                     ELGVYTYRADDPATGRVEHEYDHVLLGTLPEGVVPRPDPAEVAELRWVSVPELTAGLAD
                     TPETYAPWLAGVFRILAERSVGR"
     gene            complement(8481..9962)
                     /gene="crtI"
                     /locus_tag="ACTEI_RS00755"
     CDS             complement(8481..9962)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018217624.1"
                     /locus_tag="ACTEI_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_187646014.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.2e-07, bitscore:
                     27.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1e-16, bitscore: 60.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVTGPTDRVVIVGAGLAGLSCALHLAAAGREVTVVEREPVPGG
                     RAGRLSIGGYEFDTGPTVLTMPDLIAEPLAAVGEKLSDWLELTPVDPAYRAYYPDGSTL
                     DVRSDTTRMAAGIAAVCGAREADGYLRFVDFTRRLWQLERDHFIDRNLDSPTDLLNLNL
                     LRLLGMGAFRRLQPKINDYFRDPRTQRIFSFQAMYAGLAPHDALAVYAVIAYLDSVVGV
                     FHPKGGMHAVPKALAGAAEKHGVTIRYDTTVERVLTEHGRATGVLTAGGEVVPADTVVL
                     NPDLPIAYRDLLPARRARRLRYSPSCVVLHIGSTQAYRKIAHHNIHFGTGWKRTFDEVI
                     NRGLLMSDPSLLVTNPTRTDPAAAPAGRHTYYVLAPAPNLEAGPMNWRGGLAERYADEL
                     LRTLEQRGYRGFRDGVEVERIVTPADWADDGMAAGTPFAAAHTFAQTGPFRPSNLHPTL
                     PNVVFTGSGTQPGVGVPMVLISGKLAASRITQGVA"
     gene            complement(10001..11032)
                     /locus_tag="ACTEI_RS00760"
     CDS             complement(10001..11032)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014687233.1"
                     /locus_tag="ACTEI_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_239082730.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.1e-44, bitscore:
                     150.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRQQVSHTALVNAVEGTLADFLTPQIAMLDAIDPSLGGFARTAR
                     DLVMAGGKRLRPTFAYWGWRGVAGAGGNAEAVLPALGALELMHTFALVHDDLMDDSATR
                     RGRPTAHRIFGARHGERFGSSAAVLIGDLCLVWADQLLARTPLPAATLLEVRARYDRMR
                     IEAVAGQYLDVLGETDPASWSVDRALVVARHKTASYTVQWPLDFGLALAGTDDPEVAEA
                     YRVYGTTVGEAFQLRDDLLGVYGDPAVTGKPAGDDLRTGKPTTLLMLARRMATPAQLGE
                     LDTAGIGRKAEIVAETGAPARVEEMIRARVAEGLTALADAPIETEARSVLVELATVATQ
                     RPA"
     gene            11143..12030
                     /locus_tag="ACTEI_RS00765"
     CDS             11143..12030
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014687234.1"
                     /locus_tag="ACTEI_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_122975869.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.1e-109,
                     bitscore: 363.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.2e-68,
                     bitscore: 230.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METDLAAAYERCRALHREHGRTYYLATRLLPAWKRRHVHALYGFT
                     RFADEIVDRTESQPSDQRAAALSAWSARFLAGLRGEPVDDPLLPAVLHTIAVFGLDLAD
                     FEKFLRSMAMDLTVTGYPTYPDLLDYMEGSAAVIGTMMLPILGSSDPAAAREPARQLGF
                     AFQLTNFIRDVAEDTARGRVYLPEEHLAEFGVTRADLAARVATPAVRALIRAEVARARE
                     HYAAAAPGIPLLEPASQACMRTAFQLYGGILDEIESAGYDVFTRRATVPNRRRAAVAVR
                     SLLTRPGTRVRLAA"
     gene            12032..13354
                     /locus_tag="ACTEI_RS00770"
     CDS             12032..13354
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283453.1"
                     /locus_tag="ACTEI_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_122975870.1"
                     /transl_table=11
                     /translation="MGPRIALLTRDLRIHDNPLFAGPDPVVPLFVLDPRLGGLSANRQR
                     FLHQSLADLRGTLRARGADLVVRHGDPVAEAIRLAGRTGASTIAVAGDVTAYAQRRERR
                     LRAETVRHRIQLEITPGVTVLPPGAVRPGGGASSYRVFTPYFKAWANAGWRGLTATPAN
                     LAMPAGIAPGDLPATPAGESPDAVPGGETEGRRRLCAWLGQISRYDDDHDDMAADNTSR
                     LSAYLRFGCLSALEVALAARADDSPGAQAYLRQLAWRDFYYQVTAAFPRLSTQPLRPAA
                     DRDWRYDDDALRHWQDGLTGVPIVDAGMRQLRAEGWMHNRARLITAAFLTKHLGIDWRP
                     GLQWFFRWLVDGDVPNNSGNWQWTAGTGNDTRPYRRFNPVRQAQRFDAQGVYVRRYVPE
                     LKGVDGPAVHQPWRLPDAVRRGLDYPGPLESHRDEAVWLRA"
     misc_feature    complement(13473..13487)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.18"
                     /tool="antismash"
     misc_feature    13474..13488
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            13620..14981
                     /locus_tag="ACTEI_RS00775"
     CDS             13620..14981
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283455.1"
                     /locus_tag="ACTEI_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_122975871.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.8e-46, bitscore:
                     157.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEARQVDVVVVGLGVGGEEVAGRLAAAGLNVVGVEQRLVGGECP
                     YWGCIPTKIMVRAGNALAEARRIPGLAGASTVEPDWAPVAKRIRDEATDDWNDKVAVDR
                     FTGRGGTFVRGTATITGPGRVRVGEQEYAATRGVVVAAGTAAVIPPIDGLSGTPYWTNR
                     EAVEAATLPESMLVLGGGAIGCELAQAYARFGVRVTVIEGSPRLLSLEEPESSEVAAAA
                     LTADGVQVRTGVRARHVAHDGSFRVTLTDDTVLTGEKLLVATGRAARLAGLGLEHVGLD
                     PSARFLSTDERMRAGDRIWAVGDVTGNGAFTHMAMYEADVAVRDILGQGGPAADYRARP
                     RVTFLDPEIGAVGMTEQQARDAGLDVRVGHVPLNRTSRGFIHGPGNEGFLKLVADRGRG
                     VLVGGTTAGQSGGEMIGAVSVAVHAEVPIETLLGQIWAYPTFHRGLGEALKALV"
     misc_feature    15613..15622
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     misc_feature    15727..15741
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.5"
                     /tool="antismash"
     misc_feature    15729..15738
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.19"
                     /tool="antismash"
     rRNA            15746..17262
                     /db_xref="RFAM:RF00177"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="ACTEI_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="16S ribosomal RNA"
     gene            15746..17262
                     /locus_tag="ACTEI_RS00780"
     misc_feature    15789..15805
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.19"
                     /tool="antismash"
     misc_feature    complement(15848..15863)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.99"
                     /tool="antismash"
     misc_feature    complement(15852..15869)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    16162..16178
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     misc_feature    16837..16854
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    complement(17287..17299)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     rRNA            17602..20709
                     /db_xref="RFAM:RF02541"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="ACTEI_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="23S ribosomal RNA"
     gene            17602..20709
                     /locus_tag="ACTEI_RS00785"
     misc_feature    18077..18091
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.65"
                     /tool="antismash"
     misc_feature    19577..19590
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    19578..19591
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.67"
                     /tool="antismash"
     misc_feature    complement(19579..19592)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.1"
                     /tool="antismash"
     misc_feature    complement(19580..19593)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.03"
                     /tool="antismash"
     misc_feature    complement(19586..19595)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    19723..19736
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.96"
                     /tool="antismash"
     misc_feature    19805..19825
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.46"
                     /tool="antismash"
     misc_feature    20706..20724
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(20742..20759)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.36"
                     /tool="antismash"
     rRNA            20820..20936
                     /db_xref="RFAM:RF00001"
                     /gene="rrf"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="ACTEI_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /product="5S ribosomal RNA"
     gene            20820..20936
                     /gene="rrf"
                     /locus_tag="ACTEI_RS00790"
     misc_feature    complement(21887..21902)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 ctgcgggcgc tgggctccgg ttcgcgccgg gcggcggccc ggcggcatgc cgccgaccgg
       61 gccgggcgcc gggccagagc gaccgtacgc cgcctgcagc gcgcccaggc ccggctggcc
      121 gtcgagctca gccgggcgcc ggaggccgcc tggcgacacc attgcgaggt acgccggcat
      181 cgcgccaccc tgatcgccct gggccacccg gaagcggtcg agggagcccg ctcctggcgg
      241 cacaccgcct ccacggtcgg caccgccgcg gtggcgatcg ccgtgctgtg ggtcgccctc
      301 tccgcgctcg gcggcgcctg accaccgccg gctccggcgc tgcgcggtga ggtccgcctg
      361 ccgtccggat cggcgcggtg acgtccgcgc tcgtgaccgg gccggtcctg ttgatcctcg
      421 gggcgggtgg tcatcgggtg cgcgccgccg actgccgact accggccgcc gcggcgagcg
      481 cgcgggggtg ggcaaccggc cgcccggcgg tcagatgcgc aggaaccgca acacggcgag
      541 gacgcggcgg tggtcggcgt cggtcggggg caggtcgagc ttgctgagga tgctggtgat
      601 gtatttctcg acggcgctgt gactgacctt cagggtgtcg acgatgccgt ggttggagcg
      661 gccctccgcc atcagccgca gcacctccag ctcgcggggt gtgagccggt ccatcgggtc
      721 ctggcggtgg cggaccagca gctgcgcgac cacctcgggg tccagggcgg tgcccccggc
      781 ggccacccga tgcagggccg cgaggaagtc ggacacctgg gcgacccggt ccttgagcag
      841 atatccgacg ccgctggttc gcacggacag caggtcggtg gcgtaacgct cctcgacgta
      901 ctgcgacagc acgaggacgg cgaccgcggg aaactggtgc cggatgacga gggcggcgcg
      961 gatgccctcg tcggtgtggg tgggcggcat ccgcacgtcg atcagagcca ggtcgggacg
     1021 gtgctcggcg accgcgcgca gcagctgctc ggcatccgcc accgcgtcga cgacgtcgaa
     1081 cccgccgtcg gcgagcagtt tggtcagacc cgcgcggagc agcaccgagt cctcagcgat
     1141 cacgatccgc acggcagctc cacggtgacc gtcgtcggcc cgccggccgg gctgtgcaac
     1201 gcgaacgtcc cgtcgaccga cgcggcgcgc tgagcgagcc cgtgcagccc cgtgccgccg
     1261 ccgggtgtgg cgccgcctcg gccgtcgtcg gtgacgacga cgcggagccg gtcggcgacg
     1321 cggtccacgg tgacctcggc acggctcgcg tgggcgtgcc tggcgatgtt ggtgagagcc
     1381 tccgagacga cgaagtaggc gaccgcctcg acgaccggcg agcagcgatc cggcacgctg
     1441 acggcgaccc gtaccgggac aggtgcgcgg gctgcgatgc cggacagcgc cgcgtcgagg
     1501 ccacggtcgt cgagcaccgc cgggtgcagg ccgcggacga actcccgcaa ctcggcgagg
     1561 gcctgtgtgg cctcgtcgtg ggcctccacg atggcctgcc gggccggtgc gggcaggtcg
     1621 gtgaggttgg cccgggccat gccgagattc atcgccaggg agaccagccg ctgctgggcg
     1681 ccgtcgtgca ggtcgcgctc gatccggcgg cgctcggcgt cggtggcggc gacgacctcg
     1741 gcgcggctgc gcgacagcgt ctccacccgc acggacagct cctcgttgcg gctcggcccg
     1801 agcagcgccc gggccgccgc cgtgtcggcg cgcgccacga cgcgggccac ccacggcgcg
     1861 gcgaccagcg ccggcgccgc gaggaccagg taggcgggct cggcccaggc caggagagtc
     1921 gccgaccagc agaccgccac cgcggcagcg ccggacaccc cgatgaacag gctgagcacg
     1981 tggtagccga actgccgcca ccacccgtgc gacggtggga tctcgacgtc gagcagcgcc
     2041 cggaaccgtc ggcgctgcac cgcggacagg ccccgcacca cccgtggcag cgacagcgtg
     2101 gcggtcacgg tgagcacgac gaacagggtg gtcagcgcga ggtcgtcgcc ggaggcgtac
     2161 agcaggctcc agatcgcgct gtagccggcg ccgaccggca acccgcacgt cagcgcgaag
     2221 gcggccacgc cgagcggcag cccggccagc gcgtggaggg tggcacgcca ggtgcgcgcc
     2281 gaccagaggc cactcagcac cgtgcggagc gcgccggcgc gccggggtac agccgtttcc
     2341 accgaggtca cgggatcaac ctagacaggc ccgccggcgc gggccatggt gccaccccac
     2401 ccgcggggtg cgggtaaccc caccccggac cggctgcccg ccccaccgac agcgcgcccg
     2461 gatcccggca gggtgatcac cgttcacccc gtctcccgag gagtcgcacc atgcccggac
     2521 tcgccccggc cctcacccgc cggtcgctgc tgtcggccgc tgtcctgacc gccggcctcg
     2581 gcgtcatcac ccgcgcgccg gccgccgccc ggccacgatc ggccgccgag gggtacacgc
     2641 tgcccatgcc gaccggcccc gagcagctcg gcaccgtcgc gctccacctc gtcgaccgca
     2701 cccgtaccga tccctgggtg cccgggcggc cggttcgcga gatcatgatc cagatctggt
     2761 acccggcccg gcacatccac ggccacccgg cggcgccgtg gctgtcgccg ggcgcggtgc
     2821 cccacttctc cgagatgttc ggcctgcccg ccgagagagt ccgcgcgacg gccacgcacg
     2881 gccgggccgg cgcaccggtg cacggcggcc gtccggtcgt gctctactcg cccggtctgg
     2941 gcggcgaccg cggcaccagc accgtcctcg ccgaggagct ggtgagccac ggctacatcg
     3001 tggtcaccat cgaccacacc cacgacgcca gcgaggtcga gttcccggac gggcgggtcg
     3061 aggtggcggc catcccgccc gacatcgacg agcagatcat cgcccaagtc gtcgcggttc
     3121 gtgaggccga cacccggttc gtcctcgacc agctggccgt cgtcaacgcc ggtggcaacc
     3181 ccgacgcggg gaaccgccgg cttcccatcg gactgcgggg cgcattcgac ctgaaccgga
     3241 tcggcatgtt cggtcactca ctcggtggca gcaccgccgc cgccacgatg caccacgacc
     3301 ggcggatcaa ggccggggtc aacctggacg gcacactcgt cggcgcggcc gccgtcgcgg
     3361 gctccgaccg gccgttcctg ctgctgagca gcgaccacgg caccgacccg gaggacccga
     3421 cctgggacgc gttctggacg agccagcggg gctggaaacg tgagctgagc ctgaccggct
     3481 cggtccacgg ctcgttcaac gacggccagg tgctgtaccc gcaggccgcc ccggagatcg
     3541 gcctcacccc cgagcagctc gccggaatgg tcggcacgct gcgcccgcag cgttccgtca
     3601 ccatccagcg cgactacctc cgggccttct tcgaccagca cctgcggggc cggcgcagcc
     3661 ggctgatgtg cggcgcggac ccgcgctacc ccgagatccg tttcgtccgg taacgccggt
     3721 cagccgagcg gggcgttcat cgcacgggcg agcaacgcgt cccgggagcc ggcgccgtcg
     3781 cctgccggcc aagcccgcat ggcggcgttc aggcaggcca cggcgcaggc gacgaggggc
     3841 ccggggcggg gggtcgcgat cggcgggcag gtcacccggc aggcgggcgg cgtccagcgg
     3901 gacgagcagc tcctcccggg cctgctgctt ttcccggtgg cgggcacatc cagggcgccc
     3961 tggagaccga cccggccgac gtcgtcgcca cctccaccgt gctcgccgag gcgccggggc
     4021 cgctgggcct ggcgttcgtc ggcatcctgc acgccgaccg cgccggtgag ctggcgcaga
     4081 ggctgcgccc cgcggccgcc gcgccggtga tcctcaacca cggctcgatc tccacgccac
     4141 gggtgaaccg cgcccgggga ccgactccgc ggccggcgac cgatccggaa cggctcgacg
     4201 ccgcgatccg ccgtagcagt actagccggc agcggccggg ggcagcccgc cgtccccgtc
     4261 gacgatcgtg tccggcgtgc cgtcctcgtc gaggtccacc atcgtcaggt cgaccttgcc
     4321 gtcaccgtcg gtgtcgaact ggaacaggtc cggcttgccg tcgccgtcgg tgtccgacac
     4381 ccagacgtcg gtccggccgt cgccgttggc gtcgctggtc atcaggtcga cgcggtcgtc
     4441 gccccgggtc tgcacgacct cctgcggctc actcatatcg tctcctccag tcgggtgcgg
     4501 caccgcgcgt ccgccgatgc cggctctacc gggacggatc gtccggcaca accgccacat
     4561 cagtacccgg cgcgcgcaag gccagtcgcc ccgcctgtga cgggtgtcgc ttctggcccg
     4621 tccggccggg ggtaacgtac gccgtcgtgg atatcgcggc agacggcacg gagcacctgt
     4681 tcaccagcag cggaggcggt gcgctcgccg agcggatggg catcgtgatc accgaggcga
     4741 cggccgagcg ggtcgtcggc acgatgccgg tcgagggcaa cacccagccg tacgggctgc
     4801 tgcacggcgg ggcgtcctgt gtgctcgccg agacactcgg ctcggtcggc gcggtgctgc
     4861 acgggcagac cgtggaccgg ccgttcgcgg tcggggtgga catcaacgcc acccaccaca
     4921 aggcggcccg ctccgggctg gtgaccggga cggcggtgcc ggtgcatcgc ggccgggcgg
     4981 tcgcgacgta cgaggtggtc ctggaggacg aggccggtga ccgggtctgc accgcccgca
     5041 tcacctgtct gctgcgcggc gcctgaaccg gcggcgatcg atggccgatc cttgacggtt
     5101 ccgcgtacgt ttgcagcgtg accggagtac cacagcacgc gttcgacgac gccacgcaga
     5161 tcctcacctg cgctttcagt ggtgacagcg aggctgtggc cagcaccttc gacgcggtcg
     5221 tcgaccggga cggggtggtc ggcgcctggg acgtcgcgtg gtgcctggcc gccaccatgg
     5281 tcggggacct gcccggcggc ggtggctgga cgctggactt cccgggcatc gacgacgccc
     5341 gctatgacaa gcgctgggtc gcccggttcg tcagtgccta cgtcaacggc gacttcccca
     5401 ccggcgaggc cctcttcggc gcggcgatcg ccgacggcca gctgccggag tgcctgctcg
     5461 ccctggccgg ctccaccgtc gcgaccctgc ggcaccgcgc cgcctgacgg ccggcgcgca
     5521 gcgcacctgt ggcaccggtg tcacgacttc ttgtggtaga gcgctttcgc atactgcgtc
     5581 gcggcggcgg tgttgtacat cgacgccagt gacatgaaga acgagttgtc ggcgatggcc
     5641 cgggacgcct gagcggtccc ggagtatcgg atgtcagcct ccgcttcgga caggccacgt
     5701 gccttgaact gccggcgcat cgcggtctgg ccggtgcgga aggcctcggc ggcctcctcg
     5761 gcgttccgca tgtaggacat cgccttctcg ctcagggctt cggcaaggtt gtaggccgtc
     5821 tgttcggcct cgttggtgaa ggtgtgcacg acgctgtgcc tcctcgcaag ccgggtcaac
     5881 acggaccgat cccgataaca ctctgatcga gctgacggcg gccttcaagg ggcgaccccc
     5941 gcctgtggac agccgaggcg ccaggggtca cggccggcga tccgaggcgg cggacgccgt
     6001 cgtcacggcg gtggccgggt ttgtgccgcg gaccgatccg tggcctgtca tgtccagctg
     6061 agtggcgcgg cgtagagggc gcgggcggcg tgccgtgaat gggcaacgcc ggcccggttc
     6121 gcatccggtc acccggatcg ttcggtcagt gctccctgcc ggtctcgcgg cgccgcctgt
     6181 cctcggcgtc cgcgatgccg tgcgccaccg ccagcctgat cacccggtac agcacagcga
     6241 tacccagcag gccgagcaac accggcccga tgatccccgc atccatgttc tgaggctagg
     6301 tcacgcgcac ctcagcagct cacatacgag aacaccgccg gtgccgccgc gggtgcgggc
     6361 caccggctcc ggcgcagggc gggatcaccg aacgctgtga gagcggtcac gaagctgatg
     6421 ctcctgcggt gaggaggctg atcgaggcgc gtagcgaagg gtgaactgtg atggcgatca
     6481 tgggcgctcc gccatcgccg gagatcgact tcccgggccg gccgagccgg gaaacgacga
     6541 agcccccagc cgcgtttccg caggtgaggg cttgcgttct gagttttgct gaagagtggc
     6601 caggggcggg gtcgaaccgc cgaccttccg attttcagtc ggacgctcgt accaactgag
     6661 ctacctggcc gtgcttggtg ttgcggtcct gacgggactt gaacccgcga cctccgcctt
     6721 gacagggcgg cgagcactcc aactgctcca caggaccttg ctattcactt gctctggtgt
     6781 gtcagcgact tgcaccgcta acttaccagt acccccaacg ggattcgaac ccgtgctacc
     6841 gccttgaaag ggcggcgtcc taggccacta gacgatgagg gcaactccgc catcattgca
     6901 catcgagctg gctgctcgat cggcaacgtt tggtggcctt cgccccaacc gcgccccgtt
     6961 gaggcctgca aagcatatgt gatccaccga gcggtctcca aatcgggacc ccccttttct
     7021 ctcgcaagcc cttgaccagg gaaaacgtga gaaggtcaga cggaggcgag gagctggacc
     7081 gcctcggcga gcccggtcag ccgggtgatg ccgggcggaa gttcgtcgcc cggccagccc
     7141 ggaccggccg ccgcgaccac cagcggtggg tgcggagcgt cccggacgcg ggtgagctga
     7201 tccaccgatc cggtggccgc gcactgcgac cagagcacca ccgcggccgg gccggtccgc
     7261 ccgatcgcgt ccagcagcgc ctgcggcggc acccgggcgc cgaggagacg gctcggcacg
     7321 ccggcgtcgg ccagcgccgc ggcgagcgcc tccagcggca gggtgtgctg ttcctcgtcg
     7381 gcggcggaga gcaggacccg gggtgtgccg ggggcccgct gcgcggccgc gagcacctcg
     7441 gtgacggtcc gcgacagcag gtgctccacc tcgacgaagc gcagggtgga ctgataccgg
     7501 tcgccgatcg cggtgagcac cgggatcatc acctcggtcc aggcggggac cacgccgcgt
     7561 tccttgacgg ccgcgcagag gatgtcgcgc atcgccgccg cgtccagccg catcgcggcc
     7621 cgggtcaggc cgcggaccgt cccctcgccg ctgctggcgg cggtctgggc ggccggcggc
     7681 gccggttggt caccgggacc cgcggacggg gcgttgcggg cccaggcggc ggcctcagcg
     7741 ggcgccacgc cctgcgcggt gagccgctgc atgatcagca gccggtccat gtcctcggcg
     7801 gtgtaccgcc ggtggtgacc gggctcgtgc cggctggggc cgagcccgta acgctggtgc
     7861 caggtgcgca gggtggtgac cgccacgccc aggcggcgcg cggcggcccc cgcgctcagc
     7921 gcctcatcgg ccaaccgatc gctccgcgag aatccggaag accccggcga gccagggcgc
     7981 gtacgtctcc ggggtgtcgg ccagccccgc ggtgagctcg ggcaccgaca cccagcgcag
     8041 ctcggccacc tccgccgggt ccggccgcgg cacgacgccc tcgggcagcg tgccgagcag
     8101 cacgtggtcg tactcgtgct cgacgcggcc ggtggccggg tcgtcggcgc ggtaggtgta
     8161 gacgccgagc tcggtcagcg ggatgtcgcg tacgccgagc tcctcgacca ggcggcggcc
     8221 ggccgcgacg gtgaccttct cgcccggctc ggggtgcccg caacaggtgt tgccccaccg
     8281 cagcgggaag cgggtcttga ccgcggcgcg ctgctgcagc agcacccggc cctccgcgtc
     8341 gcgcaggaag accgagaagg cccggtgcag gcggccgggg gcccggtgcg cgtccgagac
     8401 ggtggccgaa ccgacgggct gtccctggac gtcgaccagt tcgacgaggt gctcctcgcg
     8461 ggggttgaaa acctgagcgc tcatgccact ccctgtgtga tccgactcgc ggccagcttc
     8521 cccgagatga gtaccatcgg cacccccacc ccgggctgcg tgcccgaacc ggtgaagacc
     8581 acgttcggca gcgtggggtg caggttcgac ggccggaacg gaccggtctg ggcgaacgtg
     8641 tgcgcggccg cgaacggcgt gccggcggcc atcccgtcgt cggcccagtc ggccggcgtg
     8701 acgatgcgct ccacctcgac gccgtcccgg aagccccggt agccgcgctg ttccagggtg
     8761 cgcagcaact cgtcggcgta ccgttcggcc agcccaccgc gccagttcat cgggccggcc
     8821 tccaggttcg gcgccggcgc cagcacgtag taggtgtgcc ggccggccgg ggccgccgcg
     8881 ggatcggtgc gggtcgggtt ggtgaccagc agcgacgggt cgctcatcag cagcccgcgg
     8941 ttgatcactt cgtcgaaggt gcgcttccag cccgtaccga aatggatgtt gtggtgggcg
     9001 atcttccgat aggcctgcgt cgatccgatg tgcagcacca cgcacgacgg cgagtagcgc
     9061 aggcggcgcg cgcgccgcgc cgggagcagg tcgcggtagg cgatcggcag gtccggattg
     9121 agtacgacgg tgtccgccgg gacgacctcg cccccggcgg tcagcacgcc ggtcgcccgg
     9181 ccgtgctcgg tgagcacccg ctccaccgtg gtgtcgtagc ggatcgtcac cccgtgcttc
     9241 tcggcggcgc cggccagcgc cttcggcacc gcgtgcatgc cgcccttggg gtggaagacc
     9301 ccgaccaccg agtcgaggta ggcgatcacc gcgtacaccg cgagcgcgtc gtgcggcgcg
     9361 agcccggcgt acatcgcctg gaacgagaag atccgctggg tccgcgggtc acggaagtag
     9421 tcgttgatct tcggctggag ccgccggaac gcgcccatcc cgagcagccg cagcaggttc
     9481 aggttcagca gatcggtcgg gctgtccagg ttgcggtcga tgaagtggtc acgctccagc
     9541 tgccacagcc gccgggtgaa gtcgacgaag cgcaggtagc cgtcggcctc ccgggcgccg
     9601 cagacggcgg cgatcccggc ggccatccgg gtggtgtcgg agcgcacgtc cagggtcgag
     9661 ccgtccgggt agtacgcccg gtaggccggg tccaccgggg tcagctccag ccagtcggag
     9721 agcttctcgc cgaccgcggc gagcggctcg gcgatcaggt ccggcatggt cagcacggtc
     9781 gggccggtgt cgaactcgta gccgccgatc gacaggcgcc cggcgcggcc gccgggcacc
     9841 ggctcgcgtt cgacgacggt tacctcacgt ccggccgcgg ccaggtgcag ggcacaggag
     9901 agcccggcca ggccggcgcc gactatcacg acgcgatcgg tgggtccggt gacggtgcgc
     9961 acgccgcgac tccaaggtgt ggacgagaac ggggaattga tcatgccgga cgctgcgtcg
    10021 ccacggtggc cagttcgacc agtacgctac gagcctcggt ctcgatcggc gcgtcggcca
    10081 gagccgtgag gccctcggcg acgcgggccc ggatcatctc ctcgacccgc gcgggcgcgc
    10141 cggtctccgc gacgatctcg gctttccggc cgatcccggc cgtgtcgagc tcgccgagct
    10201 gggccggggt ggccatccgc cgggccagca tgagcagggt ggtgggtttc ccggtacgca
    10261 ggtcgtcccc ggccggcttc ccggtcaccg ccgggtcgcc gtacaccccg agcaggtcgt
    10321 cgcgcagctg gaaggcctcg ccgacggtgg tgccgtagac ccggtaggcc tcggccacct
    10381 cgggatcgtc cgtgccggcc agggccagcc cgaagtccag cggccactgc acggtgtagc
    10441 tggccgtctt gtgccgggcc accaccaggg cgcggtccac cgaccaggac gccggatcgg
    10501 tctcgccgag cacgtccagg tactgcccgg cgaccgcctc gatgcgcatc cggtcgtacc
    10561 gggcgcgcac ctccagcagc gtggccgccg gcagcggggt gcgggccagc agctgatcgg
    10621 cccagaccag gcagaggtcg ccgatgagca cggcggccga cgagccgaac cgctcgccgt
    10681 gccgggcgcc gaagatccgg tgcgcggtcg gccggccccg ccgggtcgcc gagtcgtcca
    10741 tcagatcgtc gtgcaccagg gcgaaggtgt gcatcaactc gagcgcgccg agcgccggca
    10801 acaccgcttc ggcgttgccg ccggcgccgg cgaccccgcg ccagccccag tacgcgaacg
    10861 tcggccgcaa ccgtttcccg ccggccatca ccagatcgcg tgcggtccgg gcgaacccgc
    10921 cgagcgacgg gtcgatggcg tccagcatgg cgatctgcgg ggtgaggaag tcggcgagcg
    10981 ttccctcgac ggcgttgacc agcgcggtgt gggagacctg ctgtcggggt atcgctccga
    11041 gacggagatt tcccgcgagg gtgtcattgg ccacgttcag taccgtaccc taactttcgg
    11101 aagttgcgtc gattcgtgcg tcgatttatc cggaggaccg gcatggaaac cgacctggcc
    11161 gccgcctacg agcgctgccg tgcgctgcac cgcgagcacg ggcgcacgta ctacctggcc
    11221 acccggttgc tgccggcctg gaaacgccgc cacgtgcacg ccctgtatgg attcacccgg
    11281 ttcgccgacg agatcgtcga ccggaccgag tcccagccga gcgaccagcg cgccgccgcg
    11341 ctgtccgcct ggtccgcccg gttcctggcc ggcctgcgcg gcgagccggt cgacgacccg
    11401 ctgctgcccg ccgtgctgca caccatcgcg gtcttcgggc tggacctcgc ggacttcgag
    11461 aagttcctgc gcagcatggc gatggacctg accgtcaccg gctacccgac ctaccccgac
    11521 ctgctcgact acatggaggg ctcggccgcc gtgatcggca cgatgatgct gccgatcctc
    11581 ggctccagcg acccggccgc cgcccgggag ccggcccgcc agctcggttt cgcgttccag
    11641 ctcaccaact tcatccggga cgtcgccgag gacaccgccc gcggccgggt ctacctgccc
    11701 gaggagcacc tcgccgagtt cggcgtcacc cgtgcggacc tggccgcccg cgtcgccacc
    11761 ccggcggtcc gcgcgctgat ccgggccgag gtcgcccgtg cccgcgagca ctacgcggcc
    11821 gccgcccccg gcataccgct gctcgaaccc gcctcgcagg cctgcatgcg taccgcgttc
    11881 cagctctacg ggggcatcct cgacgagatc gagtcggccg gttacgacgt cttcacccgc
    11941 cgcgccacgg tgccgaaccg ccgccgcgcc gccgtcgccg tccgcagcct gctcacccgg
    12001 cccggcaccc gcgtccggct ggccgcctga gatgggcccc cggatcgcgc tgctcacccg
    12061 ggacctgcgg atccacgaca acccgctgtt cgccgggccc gatccggtgg tgccgctctt
    12121 cgtgctcgat ccgcgactgg gcggcctctc cgccaaccgc cagcgcttcc tccaccagag
    12181 cctcgccgac ctgcgcggca ccctgcgcgc ccggggcgcc gacctggtgg tccgccacgg
    12241 cgacccggtg gccgaggcga tcaggctggc cggccggacg ggcgcgtcga cgatcgcggt
    12301 cgccggtgac gtgaccgctt acgcacagcg gcgggaacgc cggctgcgcg cggagaccgt
    12361 gcggcaccgg atccagctgg agatcacccc gggcgtcacg gtgctgccgc ccggcgcggt
    12421 ccgcccgggc gggggcgcga gctcgtaccg ggtcttcacg ccgtacttca aagcctgggc
    12481 gaacgccggc tggcgcgggc tgaccgccac cccggcgaac ctcgcgatgc cggccggcat
    12541 cgcgccgggc gaccttcccg cgacacccgc cggcgagtcg cccgacgcgg tcccgggcgg
    12601 cgagaccgag ggccgccgcc ggctttgcgc ctggttgggg cagatctccc ggtacgacga
    12661 cgaccacgac gacatggccg ccgacaacac cagccggttg agcgcctacc tgcgcttcgg
    12721 ctgcctctcc gcgctcgagg tcgccctcgc cgcccgggcc gacgactccc cgggcgcgca
    12781 ggcctacctg cgccaactcg cctggcgcga cttctactac caggtcaccg cggccttccc
    12841 gcgactgtcc acgcagcccc tgcgcccggc cgccgaccgc gactggcgct acgacgacga
    12901 cgcgctgcgg cactggcagg acggcctgac cggggtcccg atcgtcgacg ccgggatgcg
    12961 ccagctgcgc gccgagggct ggatgcacaa ccgggcccgg ctgatcaccg cggcgttcct
    13021 gaccaaacat ctcggcatcg actggcgtcc cggcctgcag tggttcttcc gctggctggt
    13081 cgacggggac gtgccgaaca actccggcaa ctggcagtgg accgccggca ccggcaacga
    13141 cacccgcccc taccgccggt tcaacccggt ccgtcaggcg cagcggttcg atgcgcaggg
    13201 cgtgtacgtt cgtcgctacg tacccgagct caaaggcgtc gacggcccgg ccgtgcacca
    13261 gccgtggcgc cttcccgacg cggtacgccg cggcctcgac taccccggac cgctggagtc
    13321 gcaccgggac gaggcggtct ggctgcgggc ctgaatgctc cgcccggccc gccgggcggg
    13381 agtggggtcc accggctggg ttgcgtccgt caaaacgtct cgccggtgga ccccgcgtcg
    13441 cttacccagc gccgagccgt ccgaatcgaa ccctgggaac gctcccggcg gggcgggcgg
    13501 tgtccctcgg cgtgtccgct tccgcgccgg tccgcgaacc cgtcccaccg cccggcgcat
    13561 gagcggacgc acgagcgcgg aaccccgccc ggcggccgcg cttctgctta gctggcgcca
    13621 tggctgaagc acggcaagtg gacgtggtgg tcgtcggact cggggtcggc ggcgaggagg
    13681 tcgccggtcg cctggccgcg gccgggctca atgtggtcgg agtcgagcag cggctggtcg
    13741 gcggcgaatg cccgtactgg ggctgcatcc ctaccaagat catggtgcgg gccgggaacg
    13801 ccctggccga ggcgcgccgc atccccggcc tggccggggc gtccacggtg gagccggact
    13861 gggccccggt ggcgaagcgg atccgggacg aggccaccga cgactggaac gacaaggtcg
    13921 cggtggaccg cttcaccggc cggggcggga cgttcgtgcg gggcacggcg accatcaccg
    13981 gtcccggccg cgtccgggtc ggcgagcagg agtacgccgc gacgcgcggc gtggtcgtcg
    14041 ccgccggcac ggccgcggtc atcccgccga tcgacggcct ttccggtacg ccgtactgga
    14101 ccaaccggga ggccgtcgaa gcggccaccc tgccggagtc gatgctggtg ctcggcggcg
    14161 gcgcgatcgg ttgcgagctg gcccaggcgt acgcccggtt cggggtccgg gtgaccgtga
    14221 tcgagggctc gccgcgcctg ctctccttgg aggagccgga gtcgtccgag gtggccgcgg
    14281 ccgcgttgac ggccgacggc gtccaggtgc gcacgggggt acgggcccgg cacgtcgctc
    14341 acgacggctc gttccgggtc acgctcaccg acgacaccgt gctgaccggc gagaagcttc
    14401 tggtcgccac cggccgggcc gcccgcctcg ccggtctggg actggaacac gtggggctgg
    14461 atccgtccgc ccgtttcctg agcaccgacg agcggatgcg cgccggcgac cggatctggg
    14521 ccgtcggcga cgtcaccggc aacggcgcct tcacccacat ggcgatgtac gaggccgacg
    14581 tcgcggtgcg ggacatcctc gggcagggcg gcccggcggc cgactatcgg gcgcggccgc
    14641 gggtcacctt cctcgacccg gagatcggcg cggtcggcat gaccgagcag caggctcggg
    14701 acgcggggct ggacgtgcgg gtcggccacg tgccgctgaa ccggacctcg cggggcttca
    14761 tccacggccc cggcaacgag ggtttcctca agctggtggc cgaccggggc cggggcgtgc
    14821 tggtcggcgg gacgacggcc gggcagtccg gcggggagat gatcggagcg gtgtcggtgg
    14881 cggtgcacgc cgaggtgccg atcgagactc tgctcggtca gatctgggcg tacccgacgt
    14941 tccaccgagg gctgggggag gcgctgaagg cgctggtctg aacccgtccc ggggcgccgc
    15001 catccgggcg ggccccggga cgtccggttc tgcgcgctcc gcgtggccgg gtgtcggccc
    15061 gtcggtgccg gttctgccgt ggtccgcgtg gcacggtgtc gtcccgtccg tagcggttct
    15121 gccgtggtcc gcgtggccgg gtgtcggccc gtcggtgccg gttctgccgt ggtccgcgtg
    15181 gcacggtgtc gtcccgtccg tagcggttct gccgtggtcc gcgtggccgg gtgtcggccc
    15241 gtcggtgccg gcccgttcgg ttccggtgcc gcttcccgct gatcgccccg gtccgttcgc
    15301 cgatattcct gcgctgagct gggcggacgc gagacactag accccgattt ggagcagcgg
    15361 gaaaccagcg ggtaatgttc tgcgagccgg cagggaaacg ggcgagcgag cggagagatc
    15421 cgcagcggcc gtcctgccaa atccttgatc atctgaccac ggcagcgctg tggcctggat
    15481 cagggtggcc gtaccgggtc agatcggtgc caaccgggat taactggttg acaacgccga
    15541 gcgggccggg taacgtagag cgagtgcccc ggagggcggg ccgcggaagc ggttcttctg
    15601 atggtgtgcg gttgttcttt gagaactcaa cagggtgctt gataagccag tgccattatg
    15661 gcaatacccc ggccaggcct ttgggtctgg tgggagattc ctttggcaac ttttttgttg
    15721 tcgggattcg ctttttgaca agtttttgtt ggagagtttg atcctggctc aggacgaacg
    15781 ctggcggcgt gcttaacaca tgcaagtcga gcggaaaggc ccttcggggt actcgagcgg
    15841 cgaacgggtg agtaacacgt gagtaacctg ccccagactt tgggataacc ctcggaaacg
    15901 ggggctaata ccggatatga ccttcggccg catggttgtt ggtggaaagt ttttcggttt
    15961 gggatgggct cgcggcctat cagcttgttg gtggggtgat ggcctaccaa ggcgacgacg
    16021 ggtagccggc ctgagagggc gaccggccac actgggactg agacacggcc cagactccta
    16081 cgggaggcag cagtggggaa tattgcacaa tgggcggaag cctgatgcag cgacgccgcg
    16141 tgagggatga cggccttcgg gttgtaaacc tctttcagca gggacgaagc gtaagtgacg
    16201 gtacctgcag aagaagcgcc ggccaactac gtgccagcag ccgcggtaag acgtagggcg
    16261 cgagcgttgt ccggatttat tgggcgtaaa gagctcgtag gcggcttgtc gcgtcgtctg
    16321 tgaaaacttg gggctcaacc ccaagcttgc agtcgatacg ggcaggctag agttcggtag
    16381 gggagactgg aattcctggt gtagcggtga aatgcgcaga tatcaggagg aacaccggtg
    16441 gcgaaggcgg gtctctgggc cgatactgac gctgaggagc gaaagcgtgg ggagcgaaca
    16501 ggattagata ccctggtagt ccacgctgta aacgttgggc gctaggtgtg ggggacctct
    16561 ccggtcttct gcgccgcagc taacgcatta agcgccccgc ctggggagta cggccgcaag
    16621 gctaaaactc aaaggaattg acgggggccc gcacaagcgg cggagcatgc ggattaattc
    16681 gatgcaacgc gaagaacctt acctgggttt gacatcaccg caaatcttcc agagatggga
    16741 ggtccttcgg gggcggtgac aggtggtgca tggctgtcgt cagctcgtgt cgtgagatgt
    16801 tgggttaagt cccgcaacga gcgcaaccct cgttcgatgt tgccagcgcg ttatggcggg
    16861 gactcatcga agactgccgg ggtcaactcg gaggaaggtg gggatgacgt caagtcatca
    16921 tgccccttat gtccagggct tcacgcatgc tacaatggcc ggtacaaagg gctgcgaaat
    16981 cgtaaggtgg agcgaatccc aaaaagccgg tctcagttcg gatcggggtc tgcaactcga
    17041 ccccgtgaag tcggagtcgc tagtaatcgc agatcagcaa cgctgcggtg aatacgttcc
    17101 cgggccttgt acacaccgcc cgtcacgtca cgaaagtcgg caacacccga agccggtggc
    17161 ctaacccctt gtgggaggga gccgtcgaag gtggggctgg cgattgggac gaagtcgtaa
    17221 caaggtagcc gtaccggaag gtgcggctgg atcacctcct ttctaaggag caactttcac
    17281 cgaaaggtga cagtggcccg cgacctgcga atgtcaggtc ggggtgctca taggcggaga
    17341 cactggctag ttcgagccgg caacggccgg gacatctagt acacgccttc gggcggcgga
    17401 acgggttctg gtgcggctgg tgagggcgat aagcaccctg ttgggtatct gaaagaacaa
    17461 cctttgggtt ggtcttcaat gccaggcacg acctggtctt ccataccggc tgttttgaca
    17521 gtgctggtgg ttgatcgtgg tggttgtggg ttggtcgttg gttgagaatt gcacagtgga
    17581 cgcgagcatc ttgttttctg tggttaagtt gtcaagggcg aacggtggat gccttggcac
    17641 caggagccga tgaaggacgt gggaggccgc gataggcctg ggggagctgt caacctagct
    17701 gtgatcccag ggtgtccgaa tggggaaacc tggcacgagt catgtcgtgt catccatgcc
    17761 tgaattcata gggtgtgtga ggggaacgcg gggaagtgaa acatctcagt acccgtagga
    17821 agagaaaaca accgtgattc cgtgagtagt ggcgagcgaa agcggatgta gcctaaacct
    17881 tgcgtgtgtg atacctgtca ggggttgcac gtgaggggtc gtgggacctg ctggaacgta
    17941 ctgacatgcg ttcgaggagt tacaaagtct tatgctagtc gaacgacgtg ggaaagtcgg
    18001 ccgtagacgg tgagagcccg gtagacgaaa gtgtatgacc tccttgtggt gttcccgagt
    18061 agcagcggac tcctagaatc tgctgtgaat ttgccaggac cacctggtaa ggctgaatac
    18121 ttcctggtga ccgatagcgg actagtaccg tgagggaatg gtgaaaagta ccccgggagg
    18181 ggagtgaaat agtacctgaa accgttcgcc tacaatccgt cagagccttt cggggtgatg
    18241 gcgtgccttt tgaagaatga gcctgcgagt tagtggcatg tggcgaggtt aacccgtgtg
    18301 gggtagccgt agcgaaagcg agtctgaata gggcgttttt agtcgcatgt tctagacccg
    18361 aagcggggtg atctagccat gggcaggttg aagcgtgggt aagactgcgt ggaggaccga
    18421 acccaccaac gttgaaaagt tgggggatga cctgtggtta ggggtgaaag gccaatcaaa
    18481 ctccgtgata gctggttctc cccgaaatgc atttaggtgc agcgtcgtgt gtttcttgcc
    18541 ggaggtagag cactggatgg tctagggggc ctacaagctt actgaaatca gccaaactcc
    18601 gaatgccggt aagtgagagc gcggcagtga gactgcgggg gataagcttc gtagtcgaga
    18661 gggaaacagc ccagatcgcc agctaaggcc cctaagcgtg tgctaagtgg aaaaggatgt
    18721 gggatcgcat ggacaaccag gaggttggct tagaagcagc caccctttaa agagtgcgta
    18781 atagctcact ggtcaagtgg ttccgcgccg acaatgtagc ggggctcaag cacaccgccg
    18841 aagctgtggc attgacgcat tgctcggtag agttcttcgg gattctatcc aggcgcgttg
    18901 atgggtaggg gagcgtcgtg ttgcgggtga agcggcggag tgatccagtc gtggacgcta
    18961 cacgagtgag aatgcaggca tgagtagcga atgaagggtg agaacccctt ccgccggatg
    19021 accaagggtt ccagggccag gctaatccgc cctgggtgag tcggggccta aggcgaggcc
    19081 gagaggcgta gtcgatggat aacgggttga tattcccgta cccgcaaagg aacgcccaag
    19141 atgaacctcg ggatgctaac tgcctgaagc gtctgcggtc ttcggaccaa gggcgtggag
    19201 gccaggaccc ttctgggtag tagtttagtg atggggtgac gcaggaaggt agctgatccc
    19261 ggccggtggt tgtgccgggg taagcgtgta ggccgtgtca taggcaaatc cgtgacacat
    19321 gaggctgaga cgtgatgccg agccgttctg gtgaagtcag tgatcctatg ctgccgagaa
    19381 aagcctctag cgatgttccg agcggcccgt acccgaaacc gacacaggtg gtcaggtaga
    19441 gaataccgag gcgacgggtg aactgtggtt aaggaactcg gcaaattgcc cccgtaactt
    19501 agggagaagg ggggccggac gcgtgaagcc ccttgcgggt ggagcgtggt atggccgcag
    19561 agagcagggg gaagcgactg tttactaaaa acacaggtcc atgccaagtc gtaagacgat
    19621 gtatatggac tgacgcctgc ccggtgctgg aacgttaagg ggacctgtta gctctttggg
    19681 gcgaagcgga gaacttaagc gccagtaaac ggcggtggta actataacca tcctaaggta
    19741 gcgaaattcc ttgtcgggta agttccgacc tgcacgaatg gcgtaacgac ttccccactg
    19801 tctcaaccac aggcccggcg aaattgcagt acgagtaaag atgctcgtta cgcgcggcag
    19861 gacggaaaga ccccgggacc tttactatag cttgacattg gtatctgaat tcgattgtgt
    19921 aggataggtg ggagccggtg aagctcggac gccagttcgg gtggaggcgt tgttgaaata
    19981 ccactctgtt gggtttgggt atctaacttg cggccctgat cgggtcgagg gacagtgtct
    20041 ggtgggtagt ttaactgggg cggttgcctc ctaaagggta acggaggcgc ccaaaggttc
    20101 cctcagcctg gttggcaatc aggtgttgag tgtaagtgca taagggagct tgactgtgag
    20161 actgacgggt cgagcaggga cgaaagtcgg gactagtgat ccggcacttg cgtgtggaag
    20221 cggtgtcgct caacggataa aaggtacccc ggggataaca ggctgatctt ccccaagagt
    20281 ccatatcgac gggatggttt ggcacctcga tgtcggctcg tcgcatcctg gggctgtagc
    20341 aggtcccaag ggttgggctg ttcgcccatt aaagcggtac gcgagctggg tttagaacgt
    20401 cgtgagacag ttcggtccct atccgccgtg cgcgttggat acttgagaag ggctgtccct
    20461 agtacgagag gaccgggacg gacgaacctc tggtgtgcca gttgttccgc caggagcatg
    20521 gctggttggc tacgttcgga agggataacc gctgaaagca tctaagcggg aagctcgctt
    20581 cgagatgagg tatcccacca cctttgagtg ggtaaggctc ccagctagac gactgggttg
    20641 ataggccgga gatgtaagca cggtaacgtg ttgagttgac cggtactaat aggccgaggg
    20701 cttaaccact ctatacttta tgcttagcgt ccactgtgtg attcacagca aacgaacaac
    20761 catcccatgc tgctgtttgt ggtgtgtggg ttgctggttg tggtttcgct gatggctgtt
    20821 tcggtggtca tagcggaggg gaaacgcccg gttacattcc gaacccggta gctaagccct
    20881 ccagcgccga tggtactgca ctcgggaggg tgtgggagag taggacgccg ccggacttaa
    20941 cgttgagaaa ggcccacccc ggacggggtg ggcctttctt cgtttccacg gactggcgag
    21001 cctcgcgcct gtgtccggga ccgggccggg ccgcccggtg aggcaccgga cccggccccg
    21061 tgcggcgggc cgagtggtga gacaccggac ccggccccgt gcggcgggcc gagtggtgag
    21121 acaccggacc cggctccgtg cggcgggtac agaaacaccc cgtgcccggc cggagcttcg
    21181 aaacggggtg tctgtgtgtt ccggggggga gtcctcggac ggcggtgcgg ggctcgtggc
    21241 gtacggggaa gcgggtcaga tttttgcgat gtggaggctg cgccagtcga cgaacttgaa
    21301 gttcgtgctg gtgcgcccac catcgggggt gttctcgccg tcgtggagga ccagcaggcc
    21361 cttcgggtag ccgggcagcg cgaccgaggt ggccgcggcg ccgtcggagt gctgcacgcc
    21421 gtcgagcggg ccgtccgcga ccgtgaagcg ggtgaccgga cggttcgtgc gacggtcgta
    21481 gacgtagaag cggctgtcgc cctggctgga gacgatcagg tagccgtcgt gcctgccggt
    21541 ctggtagatc gtggcgccct cgacgtccgc ggtgatccgg ccgccgaggc ccgggtccgc
    21601 ggccgagtcc aggacgcact cctcggactc ggcgtcccag gtgcccggta cgccgtactc
    21661 tttgaccttc tcgacgatcc gcgggacgct gctgaacgtg ccgccccgca ggttgatccg
    21721 ccagagcgcg acgtcctcct gggcggcgta gagcacgccc gcctcggcgt ccaccaccat
    21781 gccctcgatc tgggggccct cacccggctc cgcgcagggc gaccaggtgc cgccgtccgg
    21841 cagccggaac gagctcggca ggtccagggt gtccgaggtg cggtaggtga cccggccgtg
    21901 cctctcctcc agccggaaga tgccgaggcg ggtgctgtgc cggcggctga ccaccgcgta
    21961 ccggtcgtag gtggccagac cgtagccggt ggcctgctcc tcgacctccg cctggtcccg
    22021 ggcgaagagc
//
