LOCUS       NZ_CP033073            10495 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces dangxiongensis strain Z022 chromosome, complete genome.
ACCESSION   NZ_CP033073
VERSION     NZ_CP033073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces dangxiongensis
  ORGANISM  Streptomyces dangxiongensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     The genome of Streptomyces dangxiongensis Z022
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. version 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 213.0x
            Sequencing Technology             :: Illumina and Pacpio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003675325.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:16:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,241
            CDSs (total)                      :: 7,151
            Genes (coding)                    :: 6,614
            CDSs (with protein)               :: 6,614
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 537
            CDSs (without protein)            :: 537
            Pseudo Genes (ambiguous residues) :: 0 of 537
            Pseudo Genes (frameshifted)       :: 320 of 537
            Pseudo Genes (incomplete)         :: 281 of 537
            Pseudo Genes (internal stop)      :: 26 of 537
            Pseudo Genes (multiple problems)  :: 83 of 537
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:47:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5132179
            Orig. end                         :: 5142674
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP033073.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Binglin Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10495
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="24"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10495
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10495
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5495](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5495
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(1248..1898)
                     /locus_tag="D9753_RS23105"
                     /old_locus_tag="D9753_23100"
     CDS             complement(1248..1898)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D9753_RS23105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="D9753_23100"
                     /product="hypothetical protein"
                     /protein_id="WP_121788729.1"
                     /transl_table=11
                     /translation="MRKFPGSPLCTTAGALAVLSVPATARAGAPPSPEASRVAFAPRHH
                     VVQQGGFVHPAADTVVGHRVAHGADAFQASADVRRLVRDSGSGLCTVARTTIARGRPAA
                     GAGGRVGPVAYDGDRGRAGDALTFSAGHRRTPVALGAPASPTDGVPNSTTNEPGAVPAR
                     RVPAYADTLGYDADVSDLGPALRHGGDQPGFRLVPHADAAWAGAHPVAVDARW"
     misc_feature    1922..1940
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    1954..1968
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            2112..2351
                     /locus_tag="D9753_RS23110"
                     /old_locus_tag="D9753_23105"
     CDS             2112..2351
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="D9753_RS23110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23105"
                     /product="chaplin"
                     /protein_id="WP_121788730.1"
                     /transl_table=11
                     /translation="MSRIAKGLVLTSAAVAAVAGGAGVASADSDAHGVAANSPGVLSGN
                     VIQVPVHIPVNVCGNTIDVIGLLNPAFANTCVND"
     gene            2692..3285
                     /locus_tag="D9753_RS23115"
                     /old_locus_tag="D9753_23110"
     CDS             2692..3285
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D9753_RS23115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="D9753_23110"
                     /product="hypothetical protein"
                     /protein_id="WP_240468254.1"
                     /transl_table=11
                     /translation="MRALGAAGSVLDPVVDLLNRSLAKGRLPTDEASRLGEAAKKAIAK
                     AAEDPAPATSASPASPAKPATPTSPASPSAAASPSSLSSAASPSAVASPQATEPATPAK
                     ADDGKPPSSRDLTDDALSALRTAIDNLVQAATGGLDQLLSSASDVVSGLVDLLGTTLLS
                     SDMPAPGGIDSLPSLPSLPALPSLPATPSLTATG"
     gene            3458..3745
                     /locus_tag="D9753_RS23120"
                     /old_locus_tag="D9753_23115"
     CDS             3458..3745
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325462.1"
                     /locus_tag="D9753_RS23120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23115"
                     /product="hypothetical protein"
                     /protein_id="WP_121788731.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSVALAGVAAPAFAYDAQHLPPLSVNGGLAHVAE
                     HPPTVTDLLPLKHQSDALDTENKDSVLSGVKGTTTTLNKKGLLGGLPVRH"
     gene            3905..4075
                     /locus_tag="D9753_RS36650"
     CDS             3905..4075
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039301.4"
                     /locus_tag="D9753_RS36650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5949 family protein"
                     /protein_id="WP_163010550.1"
                     /transl_table=11
                     /translation="MTSVPSGTRPSRATRVCPSAGPRRPATGEAPAAFAGAPEATNAAA
                     RLCLPARSLRA"
     gene            4075..4659
                     /locus_tag="D9753_RS23125"
                     /old_locus_tag="D9753_23120"
     CDS             4075..4659
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009063421.1"
                     /locus_tag="D9753_RS23125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23120"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_121788732.1"
                     /transl_table=11
                     /translation="MGRQAGASRGLALLIVLTGAPGVLASWVITLDKFKLLQDPHFVPG
                     CSLNPVLSCGSVMKSEQAAVFGFPNPMLGLVAYGIVVCAGVSLLAGARFPGWYWLLFEA
                     GCLFGVGFVSWLQFESLYRINALCLWCCLAWIATIILFWYVTSVCVRHGFLPAPHWLTA
                     FFAEFTWVLPVLHIGVVGMLVLTRWWDFWTS"
     gene            5001..5495
                     /locus_tag="D9753_RS23130"
                     /old_locus_tag="D9753_23125"
     CDS             5001..5495
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672801.1"
                     /locus_tag="D9753_RS23130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23125"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_121788733.1"
                     /sec_met_domain="melC (E-value: 2.4e-44, bitscore: 149.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVGVGGVAVGAGRRAGAGAGRPSRREVARGLLASAATLALAPVV
                     AASRPTAPAGGTASGSFDETYRGRRIQGVLMPAAGPRAAGGHWRITIDSRPLHLMRRAD
                     GTWLSMVDHYTSYRTPLEATRAAVDGLGPGRRLRDLAPGPVGDSGPGDHTYMGGRHGVR
                     A"
     gene            5479..6345
                     /locus_tag="D9753_RS23135"
                     /old_locus_tag="D9753_23130"
     CDS             5479..6345
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="D9753_RS23135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23130"
                     /product="tyrosinase family protein"
                     /protein_id="WP_121788734.1"
                     /transl_table=11
                     /translation="MAYVRKDVSTLTRTERRRFVDALLELKRRGEYDEFVRVHIDFYTT
                     DGDDGLRSAHMAPSFLPWHRRFLLELERALRRVDSSVTVPYWDWTRDRTTTSVPWTKDL
                     LGGNGRRSDQQVTTGPFAYSAGHWTIREGVTDGRFLTRDLGRAAAPIELPTRGELQGAL
                     DDPVYDAWPWDSTVRKGFRNKLEGWGTGTGSASWRNHNRVHRWVGGVMLGGASVNDPVF
                     WLHHAFVDLQWSRWQRAHHDHRYLPAEPPRATDGQHGRVVARHEKLPPWDETPDRLEDV
                     SRIYRYA"
     gene            complement(6427..6699)
                     /locus_tag="D9753_RS23140"
                     /old_locus_tag="D9753_23135"
     CDS             complement(6427..6699)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449724.1"
                     /locus_tag="D9753_RS23140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23135"
                     /product="chaplin"
                     /protein_id="WP_121788735.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVALGTSAVVISGAGLALADATAEGAAVGSPGVLSGN
                     VIQVPVHVPINLCGNTVDVIALLNPAFGNVCVNDGHESKAGGYGG"
     misc_feature    complement(6676..6685)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(7068..8027)
                     /locus_tag="D9753_RS23145"
                     /old_locus_tag="D9753_23140"
     CDS             complement(7068..8027)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672797.1"
                     /locus_tag="D9753_RS23145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23140"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_121788736.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 7.3e-54, bitscore:
                     180.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCAVLDDFQGVATELADWSVLGERVEVVSLREHLGDEDALAA
                     ALADYDIVVTLRERVPFPGSLIARLPRLRLLVASGMRNSVIDYAAAEAHGVTVCGTASA
                     STPPVELTWALLLGLARGIVQESTALRHNGPWQSTVGADLHGRRLGLLGLGKIGSRVAQ
                     VGLAFGMRVSAWSQNLTEERAAESGVELAASKEELLTTSDFVSVHLALGDRTRGLLGAA
                     ELALMKPTAYLVNTSRAAIVDQDALLAALHEGRIAGAGVDVFDIEPLPADHPMRTAPRL
                     LATPHLGYVSHANYTTYYGQAVEDVRAWLEGAPIRRLP"
     gene            8304..8660
                     /locus_tag="D9753_RS23150"
                     /old_locus_tag="D9753_23145"
     CDS             8304..8660
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153293.1"
                     /locus_tag="D9753_RS23150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23145"
                     /product="DUF4333 domain-containing protein"
                     /protein_id="WP_121788737.1"
                     /transl_table=11
                     /translation="MFKARTTTGLSILAAVAASTLLLGCSSSVEVKKSTPPTLSADKLS
                     GTLSEKLAAATGQPKPHVSCPEDLVGKVGTTSRCTLTADDGSTLGVTVKVTSVSGGRIH
                     YDFKADDKASPAPN"
     gene            8790..9227
                     /locus_tag="D9753_RS23155"
                     /old_locus_tag="D9753_23150"
     CDS             8790..9227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982720.1"
                     /locus_tag="D9753_RS23155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_23150"
                     /product="hypothetical protein"
                     /protein_id="WP_240468255.1"
                     /transl_table=11
                     /translation="MAGTEPGSTATAQSVGMRLNQLPGDAGGSPTPPGLIGGQQKLAST
                     PAQKQTAANAIEQHIQPDTRKAGDYADTETDTAVKAFHDGWHTSGALKKAHTAWGQQVT
                     NLMNMLAADKAALRSANTTLQGTDLQVGSQTNNSVSALYGY"
     misc_feature    10171..10182
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 cctgtccggc ggtgtgccgt acgtcgtgcg tggacaggat gtgatggcgc ccctgggcgc
       61 cgagcgccgc gcgcagcggc ggatcggaca gcagaccggt gaccgcgccg gccagcgcca
      121 cgggatcctc cggcggcacc aggcagtgcg cggcgagggc gggcggcagg ctctcgcggg
      181 cgccgtcgac gtcggtgagt acgacgggcc ggccacagcc cagcgcctcc agcggggcga
      241 gcgccatgcc ctcccagcgc gagggcagca ccaccaggtc cgcggcccgg taccagggca
      301 cgacgtcggt gacggcgccg gtgaagtgca cgccgggatg tgcctgccgc cgcagggcct
      361 cacggtccgg gccgtcaccg accagcacca gccgggcccg cggcagcgcg cggaggacgt
      421 cctcccaggc gcgcagcagc acgtcctggc ccttctggcg gcagaggcgt cccacgcaga
      481 cgacgagggg tgccgcctcg gcgccgtccc cgccaccggc ggggcttgtg cggcgggcgc
      541 ggccccgtgc gggctgtgcc ggtggtgcgg acggcccggg tggaacgttg ctgccgtcgg
      601 gggtctgcgg tgggtggaag ggggccgccg tgccgacggg aagggccggt gagaagcggg
      661 tggtgtcgat gccgttcggg atgaccgtgt acgcggcgcg taccccgcag cgtacgcctg
      721 tcgcacgctc cgcctcgctc acgcacacca cccggtcggc ccagcgcgcc ccccaccgct
      781 cccagcgcag ggcgagcgcc gcggtgagtc cgccgaccgc cgcgaacgac caggcgtgcg
      841 gctggaacac ggtgggcgtg cgcccgcgga cggcgagccg cgcggcgagc ccggccttgg
      901 cgctgtgcgc gtgcaccagt gcgggtcgta cgtcgtcgat caggcgcacg agccgccgta
      961 cctcgcccgg cagaccgggc cccggggacc ggcccgcccg ccactgccgt acgtcggcgc
     1021 ccaggtcccg cagtcccgcg gccagttcgc cgccggggca ggccaccgtg acccgcagac
     1081 ccgccgagag ctgggcccgc gccaggtcga gcacgaccct ggcgaccccg ccgtcgacgg
     1141 gttgcgcgag gtgcaggacc cgggggcgtg ggtcgggcgc tggctggtgc attcgcgggt
     1201 ttcctcgctc acgggggggc gctcgggatt gcggtcgtga acgcgtctca ccaccgggcg
     1261 tccacggcga cggggtgcgc gccggcccac gccgcgtccg cgtggggaac gagccggaag
     1321 cctggctggt caccgccgtg ccgcagagcc gggccgagat cggacacgtc agcgtcgtag
     1381 ccgagcgtgt cggcgtaggc cggaacccgc cgggccggta cggcacctgg ttcgttggtc
     1441 gtggagttcg gtacgccgtc cgtgggactc gcgggggcgc cgagtgcgac gggcgtacgc
     1501 cggtgccctg cggagaacgt gagcgcgtca cccgcgcgtc cgcggtcgcc gtcgtacgcc
     1561 accgggccga cgcgtccgcc cgccccggcc gccggcctgc cccgcgcgat ggtggtccgc
     1621 gcgacggtgc acagccccga accgctgtcc cgcaccagcc gcctgacgtc ggccgaggcc
     1681 tggaaggcgt cggcgccgtg cgccacccgg tgccccacga ccgtgtcggc ggccgggtgg
     1741 acgaacccgc cttgctgtac cacgtggtgg cgcggggcga aggccaccct ggaggcctcg
     1801 ggggaggggg gcgcgccggc ccgggcggtg gccgggacgg acaggacggc tagggcgccc
     1861 gccgtcgtac acagcggcga acccgggaac ttgcgcatgg ccggcggtgc cctttcgcac
     1921 gtactggaga gattcgcaac tctagcgaca tccgtatcaa tatggataaa ccgggcaact
     1981 gtgtcggaat cgtagaggca tctctcctcg cgcatcactc cattggcggc acaactccgg
     2041 ggagtgcggc gcgttgacac agcgctgggc attccgcccg gatgttgcgt cgatcccaag
     2101 gagtaccttc catgtcgcgt atcgcgaagg gcctggtcct gacctccgcc gccgtcgcgg
     2161 ccgttgccgg cggtgccggt gtggcctccg ccgactccga cgcgcacggc gtcgccgcca
     2221 actcgccggg agtgctgtcg ggcaatgtga tccaggttcc ggtccacatt ccggtgaacg
     2281 tctgcggcaa caccatcgac gtcatcggcc tcttgaaccc ggcgttcgcc aacacctgcg
     2341 tcaacgactg acaccgggac gcaacccttc ggccggccgg ccgcccgcgc atccgccgcg
     2401 gcgcggacgg ccggttctgt gttactccgg acagatcacg tcccgtgtat gagcggttgc
     2461 gtccggccgt cggtgaactg acggtgggct caggtcccca ctgttcaccg aaaggaacac
     2521 ccatgcgtga tctgcctgcc cggcgtctcg cgtccaccgc tctctgcgcg gccgtcctgg
     2581 tcggcatcac cggccccgcc gccgtcgccg ccgacacggc acgcggacac ggccacgccg
     2641 tgccccggac gcccggccca gcggcggaaa ggggagaggc tgctcgcaca ggtgagggcc
     2701 ctcggtgccg ccggttccgt cctcgacccg gtcgtcgacc tgctcaaccg gtcgctggcg
     2761 aagggcagac tgcccaccga cgaggccagc aggctggggg aagcggcgaa gaaggccatc
     2821 gccaaggccg ccgaggaccc cgccccggcg acatccgcgt cccccgcgtc ccctgcgaag
     2881 cccgccacgc ccacgtcccc cgcctccccc tcggccgccg cctccccctc gtccctgtcg
     2941 tccgccgcct ccccctcggc cgtcgcgtcc ccgcaggcca ccgagcccgc cacccccgcc
     3001 aaggcggacg acggcaagcc gccctcgtcc cgtgacctca cggacgacgc gctctccgcc
     3061 ctccggaccg cgatcgacaa cctggtgcag gcggccaccg gcggcctcga ccagctcctg
     3121 tcgtccgcca gcgacgtggt gtccggactg gtggacctgc tcgggacgac cctcctcagc
     3181 agcgacatgc ccgcccccgg cggcatcgac tccctgccct ccctcccgtc gctgcccgcc
     3241 ctgccgtccc tccccgcgac gccgagcctg accgccaccg gctgaccggc ctgcccgccg
     3301 atcggccggt caccggccca gacggggccg gactccccgc cggctccacg gggatctcat
     3361 atgtcttctc ggcgcggggt ttccggcccg gccggacctc gttaggcagg gcgtcagaat
     3421 gcccggggcg acgtgagttg ccgaggaaag gaacaccatg aagtccctga aggctgccgc
     3481 cgttgtcgcc ggttccgtcg cccttgccgg cgtcgccgcg cccgcgttcg cctacgacgc
     3541 ccagcacctg ccgcccttga gtgtcaacgg cgggctcgcc cacgtcgccg agcacccgcc
     3601 caccgtcacc gacctgctgc cgctcaagca ccagtcggac gcgctcgaca ccgagaacaa
     3661 ggactccgtg ctgagcggcg tcaagggcac caccacgacc ctcaacaaga aggggctgct
     3721 gggcggcctg cctgtgcggc actgacgtcc gccgcaccga acgggccggt accgcacccg
     3781 cgggaccggc ccccggcgtg tctccccggc cgcgtccccc gatcgtgtgg agcggccccg
     3841 ggcactagcc cggaagggtg agaagcgacc ggaccgcccc gcggcccgtc agtatggtcg
     3901 cgcgatgacc tcggtaccga gcggaacccg cccctcccgc gccacccgcg tctgcccctc
     3961 ggccggcccc cgccggccgg ccaccgggga ggcgccggcc gcgttcgcgg gtgccccgga
     4021 ggccacgaac gccgccgccc gcctctgcct gcccgcgcgc agcctgcgcg cttgatgggc
     4081 cggcaagcgg gcgcgagccg cgggctcgcc ctgctgatcg tgctcacggg ggcgccggga
     4141 gtgctggcct cctgggtgat caccctggac aagttcaagc tgctccagga cccgcacttc
     4201 gtccccgggt gcagcctgaa cccggtgctc tcctgcggca gcgtgatgaa gagcgagcag
     4261 gccgccgtct tcgggttccc caacccgatg ctgggcctgg tggcctacgg catcgtggtc
     4321 tgcgccggcg tgagcctgct cgccggagcc cgcttccccg gctggtactg gctgctgttc
     4381 gaggcgggct gcctgttcgg cgtcggcttc gtgtcctggc tccagttcga gtcgctgtac
     4441 cggatcaacg cgctgtgcct gtggtgctgc ctggcctgga tcgcgacgat catcctgttc
     4501 tggtacgtga catccgtctg cgtgcgccac ggattcctgc ccgcgcccca ctggctcacg
     4561 gcgttcttcg ccgagttcac ctgggtgctt cccgtcctgc acatcggggt ggtcggcatg
     4621 ctcgtactga cccgttggtg ggacttctgg acgagctgac cactacggca cccggggaac
     4681 ggtgcgccga agcgtttccc gctcgatacg cgctacggac gtcgaatccc cgcatcctgg
     4741 aagggacccc tcgggcggcg tgttcagggc cctgcacatg gaggtgccca ggctcggcgc
     4801 ggagctgcgg ctgctgacgg cgggcgcccc cgacgggccc gccgcgtccc gggccgtacg
     4861 cgccctgccc ccgtactccg ccgtgccccg ggccgtacgc ccccttctcc cgtacacccc
     4921 gtatggccct tcgccggtga ccccgcgccc ccctcgccgg ttaatcggta ggacatccga
     4981 acccggagga ggagcgagcg atggtcgtcg gtgtcggtgg cgtggcggtc ggtgcgggac
     5041 ggcgggccgg agcgggggcg ggcagaccct cgcggaggga ggtggcgcgg gggctgctgg
     5101 cctccgccgc caccctggcg ctcgccccgg tcgtcgccgc gtcccggccc acggccccgg
     5161 ccggcggcac cgcgagcggt tccttcgacg agacctatcg gggccgccgc atccagggcg
     5221 tcctgatgcc ggccgcgggg ccccgggcgg ccggcggcca ctggcggatc accatcgaca
     5281 gccgcccgct gcacctgatg cgccgggccg acggcacctg gctgagcatg gtcgaccact
     5341 acacgtcgta ccgcacgccc ctggaggcca cccgggcggc cgtcgacggg ctcggccccg
     5401 gccggcggct gcgcgacctg gcaccgggac cggtcggcga cagcgggccg ggcgaccaca
     5461 cgtacatggg gggccggcat ggcgtacgtg cgtaaggacg tcagcacact cacccgcacc
     5521 gagcgccggc ggttcgtcga cgcgctgctg gagctgaaac ggcgcgggga gtacgacgag
     5581 ttcgtgcgcg tgcacatcga cttctacacc accgacggcg acgacggcct gcgcagcgcc
     5641 cacatggcgc cgtcgttcct gccctggcac cgccggttcc tgctggagct ggagcgggcg
     5701 ctgcgccgcg tcgactcctc ggtgacggtg ccgtactggg actggacccg ggaccgcacg
     5761 acgacctccg tgccctggac gaaggacctc ctcggcggca acgggcggcg ctccgaccag
     5821 caggtgacca ccggtccgtt cgcctactcg gcgggccact ggaccatccg cgagggtgtc
     5881 accgacggcc ggttcctcac ccgggacctg ggccgggccg ccgcccccat cgagctgccc
     5941 acccgcggcg aactccaggg ggcgctcgac gaccccgtgt acgacgcgtg gccctgggac
     6001 tccaccgtcc gcaagggctt ccgcaacaaa ctggagggct gggggaccgg caccggcagc
     6061 gcctcctggc gcaaccacaa ccgggtgcac cgctgggtcg gcggcgtgat gctcggcggc
     6121 gcgtccgtga acgacccggt gttctggctg caccacgcct tcgtcgacct ccagtggtcc
     6181 cgctggcagc gggcccacca cgaccaccgc tacctgccgg ccgagccgcc ccgggccacc
     6241 gacggccagc acggccgggt cgtcgcccgg cacgagaagc tgccgccgtg ggacgagaca
     6301 ccggaccggc tggaggacgt gagccggatc taccggtacg cgtgaggtgc ccgccgggtg
     6361 aagcgggcac gggaagagcc ccggcgctcg gagtgccggg gctcttgcct ggggatgccg
     6421 gccggctcag ccgccgtagc ccccggcctt gctctcgtga ccgtcgttga cgcagacgtt
     6481 gccgaacgcc gggttcagca gggcgatgac gtcgacggtg ttgccgcaga ggttgatcgg
     6541 cacgtggacc ggaacctgga tgacgttgcc cgacaggacg ccgggggaac cgacggccgc
     6601 gccctcggca gtggcgtcgg ccagggcaag cccggccccg ctgatcacca cggcactggt
     6661 gccgagagcg acagcggccg ccttcgcgat gcgagacatc acgttctcct ttggtagctc
     6721 ggatagcgca gcggcagacc agccgccgca ctgtccgttc aacggcgcca cgcggggctg
     6781 gtcacggtga tcggccgggg atcacccttt caacggcaac gcgccctcgg cggacgagcc
     6841 ggggcggcgt gcacgcgcct ccggcgttat tcgcaggcac cggtccgggg ccctcaccta
     6901 ccctccggcc atggacaacg acaaccttcc cgacgcgcgc agccggcccg gcctctgccc
     6961 ggaacccggc actcccggcg cgcagccggc ccggccccgg aggccggccg agcgagtccg
     7021 agggcgcccc gggcacgccg tcggcgtcgg gcgggcggcc gtcggtctca gggcagccgg
     7081 cgtattggcg ccccctccag ccaggcccgg acgtcctcca ccgcctggcc gtagtacgtc
     7141 gtgtagttgg cgtgggagac gtagccgagg tggggtgtgg cgaggaggcg gggcgcggtc
     7201 cgcatggggt ggtcggcggg cagcggttcg atgtcgaaga cgtcgacgcc ggcgcccgcg
     7261 atccggccct cgtgcagcgc ggccagcagc gcgtcctggt cgacgatcgc cgcgcgcgag
     7321 gtgttgacca gataggcggt cggtttcatc agggcgagtt cggcggcgcc gagaagaccg
     7381 cgggtacggt caccgagggc cagatggacg gagacgaagt cgctcgtggt gagcaactcc
     7441 tccttggagg cggcgagttc caccccggac tcggcggcgc gctcctcggt gaggttctgg
     7501 ctccacgcgc tcacccgcat cccgaaggcg agcccgacct gcgccacccg gctgccgatc
     7561 ttcccgagcc cgagcagccc cagccggcgt ccgtgcagat cggcaccgac ggtcgactgc
     7621 cagggcccgt tgtggcgcag cgcggtgctc tcctggacga tcccccgggc gagaccgagc
     7681 agcagcgccc aggtcagctc gaccggtggg gtactggcgc tcgccgtacc gcacacggtg
     7741 acgccgtggg cctcggcggc ggcgtagtcg atgacgctgt tgcgcatccc ggaggcgacg
     7801 agcagcctca gccgggggag gcgggcgatc agggagccgg gaaaggggac gcgttcgcgc
     7861 agggtgacga cgatgtcgta gtcggcgagg gcagcggcga gggcgtcctc gtcaccgagg
     7921 tgctcgcgca acgagacgac ctccacccgc tccccgagca ccgaccagtc ggccaactcg
     7981 gtggccaccc cctggaagtc gtccagcacc gcacaacgaa gtcgcacgtc gtctccctcc
     8041 cgcctacgac tctaacgacc acccctcgac ggggcgttcg tcaggcagca cagcgcgtcc
     8101 ggtctcgcgc cggggcctca gccctgtacg cgcgcctctc gacgtggtgc gacattcccg
     8161 tcgatgacgt gaaggcatat ggagaatccg tgtgaccggg gaactgtgtg accgtcatgg
     8221 ccgtcccctt cggcatgtcc acggcatccc gccagtatgc tcttcgggtc ttctcgccct
     8281 gaccagccga ccaggagtgc acgatgttca aagcccggac gaccacaggc ctgtcgatcc
     8341 tcgcggccgt cgcggccagc acgctgctcc tgggctgctc gtcctccgtc gaggtcaaga
     8401 agtccacgcc gccgacgctg tccgcggaca agctctccgg cacgctctcc gaaaagctcg
     8461 ccgccgccac ggggcagccg aagccgcacg tctcctgccc cgaggacctc gtcggcaagg
     8521 tcggcaccac ctcgcgctgc acgctcacgg cggacgacgg cagcaccctg ggcgtgacgg
     8581 tcaaggtcac ctccgtcagc ggcggccgga tccactacga cttcaaggcc gacgacaagg
     8641 cctccccggc gcctaactga cctgctcgcg gaaccagttg ggtcagatcc gcttactcgg
     8701 ccgagggcgc tacggtacga gcggatcgtt gcgacggggg cgtccgccac gccggcgccg
     8761 ggcagcggca gacacgggag gcaaggctga tggcaggcac ggaaccggga agcaccgcga
     8821 cggcacagtc cgtcgggatg cgactgaacc agctaccggg cgatgccgga ggctccccga
     8881 ctccaccggg cctgatcggc ggtcagcaga agctcgcctc cacgccggcc cagaaacaga
     8941 ccgccgccaa cgccatcgag cagcacatcc agcccgacac ccgcaaagcc ggagactacg
     9001 cggacacgga gaccgacacg gcggtcaagg ccttccacga cggatggcac acctcggggg
     9061 cgctgaagaa ggcgcacacg gcctggggac agcaggtgac gaacctgatg aacatgctcg
     9121 ccgcggacaa ggcggccctg cgcagcgcca acaccacctt gcagggcacg gacctgcagg
     9181 tcggttccca gacgaacaac tcggtgtcgg cgctctacgg gtactgaccg ggcggtgcca
     9241 cgcggctggg tcctgggccg aggccgcaac tcgcagacag ccgggcaatg acaacgggga
     9301 acccatgccg acgtatcacg agatcatgac gaccgacctg tccgcgctca cgacggccgc
     9361 agagcgctgg gacgggatgg cgaaagagtt caacaagcag gagaccgcct accggcgcga
     9421 cgtctacggc atcaccctgt ctccgggctg gtcggggctg agcgcggacg ccgcgaacgg
     9481 acgcttcaac gtcacgctca agcagttcca ggccgcgcag gtcgaggcga aggcggtggc
     9541 ctcactgctg cgtgaggcgc acacggactt cacggacctc cgcaagaagc tggagtccgc
     9601 ccgggcggac gccgtcaagg cgggcatggc ggtatcggag ggaggcgtgg tctcgtacga
     9661 caccacgaag ctgtccgacg gtgagcgcaa cgccctgcac cacgaccccg actaccagca
     9721 ctccgtcggc aaggccgtca cctcctggca ggcggagatc gatcggctcg tgaaggagat
     9781 gggcgacacc gacaccgagg tcgagaacgc cctcacccgg gtggtgctcg actccgacct
     9841 cagtgacggc acgctcaccg gcttcaacgg ccacgcccac ggcgacatca agacgtacga
     9901 ggacgaggcg gagcgagagg ccgcccggac cgaacccgac gggtggaagt ccgaaggaaa
     9961 gaccgagacg tccggccccg gtgtcggggc gagtgcgacg gggccggact tcggatccgg
    10021 caaactcggc gaggcggagg cgcacgccga cctgggcagc gcgagcgccg agggctcgct
    10081 cacccggggg ccgtggaaac tcgacggaaa ggccgaggcc tacgccggag ccaagggttc
    10141 cgccagcggc ggcgtctccc agaacggcgt ggaagggaac gcgagcgtct tcgcgggggg
    10201 tgagggctcc gccgagggcg gtgtcggtgt cggcccggtc ggcgtctccg cgaaggtcga
    10261 gggcatggcg ggggccgagg ccaacgtcga cgcgggggtc ggcggcgagg gtgtacacct
    10321 ggggggcgag gccttcgcgg gcgccaaggg cggcggcgag gtcggcgcgg acgtcggagg
    10381 ggtctcggcg ggcttctccg cccagggttg ggccggtccc ggcgccgaag ccagcctgga
    10441 cctcggcaag aacaacgaag gcgtgtggaa attcagcacc aaggtgggtc tctct
//
