LOCUS       NZ_CP033073            26329 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces dangxiongensis strain Z022 chromosome, complete genome.
ACCESSION   NZ_CP033073
VERSION     NZ_CP033073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces dangxiongensis
  ORGANISM  Streptomyces dangxiongensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     The genome of Streptomyces dangxiongensis Z022
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. version 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 213.0x
            Sequencing Technology             :: Illumina and Pacpio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003675325.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:16:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,241
            CDSs (total)                      :: 7,151
            Genes (coding)                    :: 6,614
            CDSs (with protein)               :: 6,614
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 537
            CDSs (without protein)            :: 537
            Pseudo Genes (ambiguous residues) :: 0 of 537
            Pseudo Genes (frameshifted)       :: 320 of 537
            Pseudo Genes (incomplete)         :: 281 of 537
            Pseudo Genes (internal stop)      :: 26 of 537
            Pseudo Genes (multiple problems)  :: 83 of 537
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:47:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4500181
            Orig. end                         :: 4526510
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP033073.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Binglin Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26329
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="22"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26329
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16329](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16329
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(43..56)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.54"
                     /tool="antismash"
     gene            545..1243
                     /locus_tag="D9753_RS20260"
                     /old_locus_tag="D9753_20255"
     CDS             545..1243
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025840.5"
                     /locus_tag="D9753_RS20260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20255"
                     /product="DarT ssDNA thymidine ADP-ribosyltransferase
                     family protein"
                     /protein_id="WP_121788277.1"
                     /transl_table=11
                     /translation="MNDILEQGRARGITRLCHLTKSANLSHILDTRQIRPVAVLQTAAD
                     AYRPADTQRLDGAPEFTFLSVEYPNTWYLAQAASRDRYFQDWVVLTLDVDLLAAPGARF
                     SPYNSARDRSAGARTGADGFNAMFAPTVTGKVTLRRERGHPSWWPTDDQAEIQIPGTIP
                     LSAVRTVIVRDEKQAELEHFRHGRFGMAALLPPLVVAPVLFDKYALSRSVRSGKRPLET
                     PYIPGTTLAE"
     gene            1290..2996
                     /locus_tag="D9753_RS20265"
                     /old_locus_tag="D9753_20260"
     CDS             1290..2996
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015692.5"
                     /locus_tag="D9753_RS20265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20260"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_121788278.1"
                     /transl_table=11
                     /translation="MLLGAAVGDAMGWPYERRDRTRSLPPLSQVSGRFFAWQRMAGSRF
                     RPILEEIGPGEYSDDTQMLIAVARARLSAGDDWLTWLQRVEWPFFPDYERGAGASVKRA
                     CRAWEKHEAAWGHRTDDQEKYFSAGANGAAMRIAPHVIVHHERPFGDLAADVVRDAATT
                     HGHPRALLGALVHAYALWISLRQPAPLAYGWLVEATLDGLKDWREPVWQGLDQHWRDAA
                     AKAFPSDYERAWDDTVQEVEDLLSSARSSLDSGALSAPSAFLEEHGLTRTRTRGSGTLC
                     AVAAIYLAARSAAGPERGMAVPARQEGADTDTLASMTASLLGAGLGQEWLGSFGRTVQD
                     GALLITLAEKLLRPVSETLPPPSHDEVGEARSRFLHELDGADSRAGLLLPDRRQARVVA
                     GTTLTSGNWTAQRTQLLTADGQNLFIIRGVQRVEAKRVQEAPRTEVAQAAEHRPFRPAT
                     QARLQGAYLPVADISRVTEALTALGLTAPRRGNDWVSYENLVIRQAPAGERATGFPAAQ
                     LRVAISDVQAAWERLRAMEFEGAIQRDGSAFWLRVDPHLIVAVNNAESPAG"
     gene            complement(3123..5804)
                     /locus_tag="D9753_RS36615"
     CDS             complement(3123..5804)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1295: Sel1 domain
                     protein repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D9753_RS36615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="sel1 repeat family protein"
                     /protein_id="WP_163010744.1"
                     /transl_table=11
                     /translation="MISDRGRQSVQQDAHATDNARIYQAGGDIIIHEGDALQRRRLAAQ
                     ATGQPISEVTNPYTLSVKQAITASPSTGGENLPELPLYIERDHDQRLRDVTQHAAAGAS
                     GIAILVGGSSTGKTRACWEAIQSLPNHWRLWHPVDPSGLQEILSVADAIQPHTVVWLDE
                     IQHYLLTTTSSLGEQVASKLRTLLRDPKRAPVLVLGTIWNEYWITLTTSPTSGKADPHA
                     QARALMMGKDVPVPEVFSERALDTLRATVKTDPRLKLAAENAEQGHITQYLAAAPALME
                     RYRNAPPAAKAVIDAAMDARRLGHSLALPLTFLEAAAPGYLTDLQWDQSADDWLQQALN
                     YAAIPLNGARGPLSRMRPRPGKARFNEPHYRLADFLEQDARTARKFKAPPSTFWDAAAL
                     HVSNPDDLTSLASEAQKRLRLQHSVRLYLKAADMGDLNALIQLSGFLEKAGNREGSEEI
                     LLHVAASGNTDPLVNLARAAEGEESIRLYQLAIELGDPQALVELCLMREESGDHDGAEQ
                     LISQAVNTGNTDALIALAEQRDFSGDDQAGAKRLYEYAIAAGDIDAMVALAEMLDEIGD
                     FESAERAFQQAADLGSTYAVRCLALAAKEAGDLAEAERLYQNAVNAGDIDAFDGLARIR
                     EESGQYEAAENLAHRAAEAGNPYVLGNLADMREESGQHKEAELLALRAIRYGNTNALRD
                     LVDNRDDDGKYEEAERLAWLGVKAGSTDALFHLANSRGEDDDWESVERISVRAAEAGIT
                     GAFNLRSLALMREHAGDLESAERIALAAAKAGDTSHLTEIALLRDREESRRLFQLAVDA
                     GDVGALFNLAWMCVDDGDFAEAERLAFQAADAGDPFALQHLAGERSYEPRWQKLLKHGL
                     EADGRVCEPWVPPSPTVTQPEQ"
     misc_feature    complement(4884..4886)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5801..6217)
                     /locus_tag="D9753_RS20275"
                     /old_locus_tag="D9753_20270"
     CDS             complement(5801..6217)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D9753_RS20275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="D9753_20270"
                     /product="hypothetical protein"
                     /protein_id="WP_121788280.1"
                     /transl_table=11
                     /translation="MEPLVLAVGTALVSAMATDAWQQARASAVTLWQRVHPERIPVIEG
                     ELAEVRDEVLAARESGDAEAESELAADWQRRLRRLLQNDPTLGDELRRVLDEELTPLLT
                     AAVRDSLKKVEMHARASGRARIFQAAGNQTINES"
     gene            complement(6489..7028)
                     /locus_tag="D9753_RS20280"
                     /old_locus_tag="D9753_20275"
     CDS             complement(6489..7028)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000005.1"
                     /locus_tag="D9753_RS20280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20275"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_121788281.1"
                     /transl_table=11
                     /translation="MTTAPAIELRTFTTLDTARGDLLDVYAEVRAPLLHLPNYAVTAFG
                     ERLDRHSTEPGFTAVLAYADGHPVGYAYGNTIEHGDRYWQRTSPTPADIYTERPALALK
                     EIGVRPTWRKTGTARRIHDTLLATRDEPYVTLMVNPAAGDGKVHALYESWGYEDIGQSQ
                     PSPASPVLTVMIRASR"
     gene            complement(7025..8308)
                     /locus_tag="D9753_RS20285"
                     /old_locus_tag="D9753_20280"
     CDS             complement(7025..8308)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000004.1"
                     /locus_tag="D9753_RS20285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20280"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_121788282.1"
                     /transl_table=11
                     /translation="MDTTRNTVLEAWMTEHGYSSNSLAEAVNRAIERLTGRPGGLDGSS
                     VRAWKAGRVTWPKSAARKALEDVTGLPAVALGFVPRSRPSSTPAPPQQEDPDMKRRTLV
                     GSIAAAAAAAAAPGTASPRRIGMSDVNRLNKRFAEIIASDHRHGGQLGIEQRAAALADE
                     ALNLQNAGSATQRVRSNLYASAAAFRSSAMWAAIDGRRYDVAKAHMREAQALAEMSGDQ
                     AIKFRIWSHAGTMYRHMGRPADALAANDVARNLHLTRRDPLFASLGLARQGAIHGTAQD
                     RTGIRRAFEQAQDAMLRADPADYRPVWMLAFYDQAELDSLALSANLALGDYSAAEYHAH
                     RCLSALRPHMIRSRAIATTRLAHAQLAQGAPDAATATAMKVSAEAATQHARVTRMLQEF
                     GAALRATAPGSSTVQTWTEHTATWRMAA"
     misc_feature    complement(8081..8083)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8550..8997
                     /locus_tag="D9753_RS20290"
                     /old_locus_tag="D9753_20285"
                     /pseudo=""
     CDS             8550..8997
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763666.1"
                     /locus_tag="D9753_RS20290"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20285"
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSLRKTVEGPLRRSPHVQPDLPVRAVHG"
     gene            9225..9413
                     /locus_tag="D9753_RS20295"
                     /old_locus_tag="D9753_20290"
     CDS             9225..9413
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337811.1"
                     /locus_tag="D9753_RS20295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20290"
                     /product="hypothetical protein"
                     /protein_id="WP_019759144.1"
                     /transl_table=11
                     /translation="MEWPWITGDCWLGCGRTGVLVIWLGPVQWDGQHAPFYACEPCLDR
                     LKAQALAYFMERRPASA"
     misc_feature    complement(9528..9542)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.29"
                     /tool="antismash"
     misc_feature    9529..9543
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            9604..9783
                     /locus_tag="D9753_RS20300"
                     /old_locus_tag="D9753_20295"
     CDS             9604..9783
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="D9753_RS20300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20295"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_016825826.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5e-13, bitscore:
                     47.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSTVVPSRTEVRPQIPGASDGFDLDVSLVEIADPAGLVNLTDD
                     NCGSTCGACTTNVA"
     gene            10001..12955
                     /locus_tag="D9753_RS20305"
                     /old_locus_tag="D9753_20300"
     CDS             10001..12955
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543779.1"
                     /locus_tag="D9753_RS20305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20300"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_121788284.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-198,
                     bitscore: 659.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-20,
                     bitscore: 72.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.3e-22, bitscore:
                     76.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWLRAVWADKDITEALQHSSPVLAAQVRALCTAEHPALRDVQRA
                     ALSVARYLLRAQHRATPFGLFAGVATAAFGPQARADWGEEHVAVGRAGAEWLAALVARL
                     ESCPDLLERLPVVINNTVTYRGDRLIVPFQPDVKDDRTRAVEASLALTGPVRAVLAATR
                     APIRFGTLADKLQAEFPEAGPEKARQLLAELIRRRVLITGLHAPSTETDALGYLVGQLD
                     AIDAGSLAPVAETVRELHAIRAGLEECATYGGRDSVAARMRDLIPGLRRHPVALDLRLD
                     ARIVLPEAVAREIERAALVLTRLSIRPYGTAAWNDYHQRFYERYGIGTMVPLAEVVADS
                     GTGYPDGYPGAPADARRPRVSARDDALVRLAQAAALDGRDEVILTDEQIEALDVGPDEP
                     RLPPHLEIGVRVHAVNLEELQRGRFRLEAVSVSRGAGVSTGRFLSVLAPADRDAPVAEL
                     ADLPAADGNTVPAQLSFPPLLPESAHVTRAPQVLPTVISLQEHRVPQDTVLTPEDLAVG
                     CDGRRMYLAVPERGQRVEVVGMHALNLRTHTPPLVRFLTELSRAQCAQVTVFDWGAAAA
                     MPFLPRLRYGRTVLAPARWRLEASELPGHARPRTEWDAVLGDWRARRRLPRRVHLVEDD
                     RRLFLDLDEAGHRALLRRHLDHSRLAVLVEAPEPEAYGWCGGRAHEVVVPLKATRPPTW
                     PPLSAPSRARALSADQIQTPASSSVLLAALYGDPRRQDMLLSQHLPGLLEQLGNPPWWF
                     IRFRDPDQHLRVRIALPDPEAFADTARTVSAWADELRCVGLLADLRYPTSYREMGRWGS
                     GTAWEAAEEVFRADSRSILAQLTQPQRPGQRTLVAAHTVAITSAFLGSTAAGMRWLIDH
                     IPPTAPAPVPRPQFTDAARLADPSDDWVTLRSVPGGDAIVSAWADRDTTLAAYRPHLPG
                     PDTQGIAVDDVLTSLLHVHFVRHVAVNFPEEEVCLYLARAAALAWTARTRGRAS"
     aSDomain        10346..10621
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_D9753_RS20305_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.90E-23"
                     /identifier="RREFam001.1"
                     /label="D9753_RS20305"
                     /locus_tag="D9753_RS20305"
                     /protein_end="207"
                     /protein_start="115"
                     /score="72.0"
                     /tool="antismash"
                     /translation="VVINNTVTYRGDRLIVPFQPDVKDDRTRAVEASLALTGPVRAVLA
                     ATRAPIRFGTLADKLQAEFPEAGPEKARQLLAELIRRRVLITGLHAP"
     misc_feature    12380..12382
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12952..14226
                     /locus_tag="D9753_RS20310"
                     /old_locus_tag="D9753_20305"
     CDS             12952..14226
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="D9753_RS20310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20305"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_121791185.1"
                     /sec_met_domain="LANC_like (E-value: 3.8e-41, bitscore:
                     139.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARPALGLVDAIADRLADPDTVPLGSRTLSSDRQHLAYGPPGIA
                     LLHIERAASGLGPWHRAHAWLAAACRQPLTSGPDSHPFYGAPAFAHALTCAADHLPGSY
                     QRALNAMDGQIAVNVGRRLDAAHRRIDAGRLPQLAEFDAIRGLTGYGAYLLRRNPGSST
                     MRAVLDYCVRLTEPITHHGETLPGWWTETGPSGSPDDRFPGGHANTGMAHGIGGVLALL
                     ALAARNGSVTDGHHAALHTILTWLDRWKQRADGGPVWPYWATQDELRRGRLAPSAPRRP
                     SWCYGTAGLARAQQLAALALGDTSRQIDSENALVAALTDPEQVKATTDNGLCHGFAGLA
                     HAAARTADDAHPSTAGKLRAAIPALLAAVTPPDTDPELTATALIQDQEGGPGLLDGAAG
                     IALALLAPSTAAPPRSAWDACLLIA"
     gene            14248..16329
                     /gene="fxlM"
                     /locus_tag="D9753_RS20315"
                     /old_locus_tag="D9753_20310"
     CDS             14248..16329
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="D9753_RS20315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20310"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_121788285.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.8e-24, bitscore:
                     83.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.8e-44, bitscore: 150.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDRWQQHNITFVDREMARRTIAERLGPALIEAEADGQLTGWWF
                     MNKQPWPLRYLADKPSSAIESLLSDLIGDGVATLCLPCVYEPETDAFGGPEAMEAAHEL
                     FHSDSRHLLTYQPSPMHLGRRETAVLLASAMMRGAGLDWFEQGDVWAKVAALRPVTNPP
                     HLERAAELISPMQKLMTADALSLCRRNGPLHRYDEWVTAFVRAGATLADLAARGALTRG
                     LRAVIAHHVIFHANRAGLLRHDQSALSHIAREVVMGTSDHTESPTEATADIDSVSAVNT
                     DTTTTPTADAERLRNALVDQLRTDGHARTPAVETALRTVPRHVFVPDASLEDAYANAPV
                     HIKYDTDGTSISCASQPGVVALMLDQLEAQPGERILELGAGTGYNAGLLAHLVGESGHV
                     TTLDVDDDLVEGARVHLAAAGITNVEAVTRDGALGYAEAAPYDRIIATVGAHGVAHAWL
                     QQLAPGGRLLVPQRLKGTVSRSIAYEQRDGRWVSLGSEMNTFMPLRRGIADDDRRVIPL
                     STDGAVRLQAPAGLNIDADALAGVLDQPHTEEWTGMTVRAMESPEWMELFVTCSLPSGL
                     IRMLFPQSAKGTLLTEDPYPSSTAVVDKGAVTYLARRLSKEKTHDGDRLWEFGVIGHGP
                     GSDELVARVADAIRTWDRDYRDREATFEIQPLDAPEIEQRPGLFALDTPLNRIVVDWR"
     misc_feature    14278..14292
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            16418..17551
                     /locus_tag="D9753_RS20320"
                     /old_locus_tag="D9753_20315"
     CDS             16418..17551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612040.1"
                     /locus_tag="D9753_RS20320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20315"
                     /product="hypothetical protein"
                     /protein_id="WP_121788286.1"
                     /transl_table=11
                     /translation="MDPHGLTAQRFPLVARFRPACLPLPERVRALVDLADTAVKKADQG
                     LASAVYNQAALIASDLDLPDLAREMCHQHAAAYLHACPLPGMSAIRGLEPVVNLARLQI
                     RAGHADEGRQRLLDLYKAVETGTAARFEGVNVPADLTATGEDRQEVRAWLWRVLLADGT
                     RTLTTEGRWAEALAHIEAHHGIGQRMLDGRQVAVLTALVANDTAGAAGLLADTMPGDPW
                     EQAVTACLTVLCRSDAGQPIDSHLADLLTTYSGRKAEPGMTVFDTRLGLTVLDAIGSAE
                     ALAAHCIVEDLHRRTTDAEDGYAARENLAHPRFTEIATDRQVQDCRALASACALGTGVL
                     PDELRGELTSALRASDSVIRESLTRSSDPGRTQPLRA"
     gene            complement(17558..19273)
                     /locus_tag="D9753_RS20325"
                     /old_locus_tag="D9753_20320"
     CDS             complement(17558..19273)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002506.1"
                     /locus_tag="D9753_RS20325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20320"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_121788287.1"
                     /transl_table=11
                     /translation="MIAAIKPAGSNTRGLLAYLYGPGDHDEHLDPHIVAGFAMLGLPDL
                     GRDENATLTELARYLDEPVRLRNGEFGKQVTDHVWHCPVRAAPEDRYLSDAEWGEIAQR
                     IVEAAGIAPTGDDLGCRWIAVRHADDHIHILATTVREDGRRPKLHGSGVRVGDECREIE
                     KDYGLRQLKKGDGTGSRRPTQAEMHKAERLGWDQPSAEWLQDRIRAAIPHVTSAEEFIA
                     YLQASGVEVQVRRGPSGDLLGYAAGRPGDVNEAGEQIYHPGSKIAPDLSLPKIKARLES
                     SRPEEHPTARRKHPSTPWHQAADALDMLHTDLADDTHAQAHITALGELLEATAQKVPAP
                     LRAELQAASKAFARAQRSQVRAEDRAALALRGAARDIVHTATGPDGSALAALVAALVWA
                     TIVAARWHEAKHHAHQADAARQAVQHLQTAADLALAPTLAELTARPPRDEASRILAGDV
                     RAAVPDHAERILTDPAWPALATVLADAEARGHQPHQLLREAAAQRELTTALQPARVLIT
                     RIQHTGRNPAPNRRAEAARRRSTLAASVRVRQSHDGQFPSAATTPTEQQRRQRR"
     gene            complement(19270..19839)
                     /locus_tag="D9753_RS20330"
                     /old_locus_tag="D9753_20325"
     CDS             complement(19270..19839)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476783.1"
                     /locus_tag="D9753_RS20330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20325"
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_121791186.1"
                     /transl_table=11
                     /translation="MAETAQHQGAPGQGVGAEGGSDEDMLHTLQCETLRRVRAVDIAES
                     VGGEPVVKSVQPTIRRFTGTKRVVRVGPLRFTGDEHTRLQETAAEHGYRGDSGFAADIV
                     LAFITGHFTANLPLSEDRRRTHVFRAQVLRQLNRIGVNVNQIARALNSDHTPPDIRQRL
                     TELHQLLELIAEALRQPADPETEAAA"
     gene            complement(20185..21111)
                     /locus_tag="D9753_RS20335"
                     /old_locus_tag="D9753_20330"
     CDS             complement(20185..21111)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961490.1"
                     /locus_tag="D9753_RS20335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20330"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_121788288.1"
                     /transl_table=11
                     /translation="MSRRRDRPPRGDQPGEKQPAKAKLSAEQYVLRAAGIVIVALTAGA
                     FWLSYAHLAEVAAQHGLRDSPIRRWAWPATLDAFIVAGELLMLRAGLRRVTDPWAIGVT
                     AIGSFGSIGLNVAGVTGTRDVGSVSLLDYVVAAVPPAAAMVAFGVLMRQIHELVAQPDV
                     DQSGPDSVQVPEPSVTTSVHLAEAPAIAVGRSGEVPAGRFGPAELLTEPVQAAGLSAAV
                     SVQSPKPPASAAAGKVRGGRPPGAPLEELVEIGRAAAAEQGKLTRAVVRTAVEDKGLTV
                     GSKRLTEVMNLLRAEPDAAAETHRSSG"
     gene            complement(21579..22907)
                     /locus_tag="D9753_RS20340"
                     /old_locus_tag="D9753_20335"
     CDS             complement(21579..22907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482626.1"
                     /locus_tag="D9753_RS20340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20335"
                     /product="DUF3631 domain-containing protein"
                     /protein_id="WP_121788289.1"
                     /transl_table=11
                     /translation="MQPENPEPYSAPAQAIWPAAAIPGRPGAHLHATQADDADPSPGSD
                     ADARSTDEAKTPSGPEEISDAEPTYGSELLDELRGQIAQFVIPPSQEALDAITLWVAAT
                     HLQPAWQHAPRLAVVGPAKRCGKSRLLDVLTETVHEPMLTINTTPAAIFRSISEDNPPT
                     LLVDEADTIFGPKVAEKNEETRGLLNAGHQRGRYVTRVVGNDHTPHRFATFAMAAIAGI
                     GELPDTVMDRSVVIRMRRRAEGEKVKPFRSRRDIPALHDLRDRIAAWARPLLDEAANLE
                     PDMPVEDRAADTWEPLVIVADLAGGRWPRLARLACARMVAAEVAAEEEHPSGARILADI
                     RRVFHAQREVDSLSTEELLHHLRQDAEAPWAEWGRGGLTARELGRMLREFEIRPGNVRM
                     ADRTQRKGYMRNKFLDAWSRYCPTVHSVDPQAARPVNHPPFTE"
     gene            complement(23123..23353)
                     /locus_tag="D9753_RS20345"
                     /old_locus_tag="D9753_20340"
     CDS             complement(23123..23353)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961488.1"
                     /locus_tag="D9753_RS20345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20340"
                     /product="hypothetical protein"
                     /protein_id="WP_121788290.1"
                     /transl_table=11
                     /translation="MRENGLAGRVKGMSREELLELPAAVDLETGNRALGLGRSKGYELA
                     KRGQYPCKVLRLGNAYRVVTADLLALLGLAA"
     misc_feature    complement(23383..23397)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.54"
                     /tool="antismash"
     gene            23448..24134
                     /locus_tag="D9753_RS20350"
                     /old_locus_tag="D9753_20345"
     CDS             23448..24134
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321526.1"
                     /locus_tag="D9753_RS20350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20345"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_121788291.1"
                     /transl_table=11
                     /translation="MTQHGFDAGRDEDDVPEWVDQVMATVAAEVRRRRKELHMSAQDLA
                     DRCEEIGHPIPRNVIANMESGRRANLPLVDVIVLAEALDTYPICLLYPVGYVDRVQRLP
                     LQHSERTWDAMRWFTGDREELGREDAMLRSFRAHIRHQRAALAALKGEKHERWKAETAP
                     NKAEREEALLAQADYAERVLEAKYRLRSARAFIREDGGTPPHLPPELADVDPPETAPNT
                     TEENDL"
     gene            24131..25804
                     /gene="xerC"
                     /locus_tag="D9753_RS20355"
                     /old_locus_tag="D9753_20350"
     CDS             24131..25804
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009037 - tyrosine-based site-specific
                     recombinase activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xerC"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321541.1"
                     /locus_tag="D9753_RS20355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_20350"
                     /product="tyrosine recombinase XerC"
                     /protein_id="WP_121788292.1"
                     /transl_table=11
                     /translation="MKGSTHRRCYCRDPHTGKPLGKKCPKLSSRKHGSYSIRQELPPRE
                     DGTRRSFSRAGYDSLKAAQVDLDHVRALVGLADADDAEGLAQIAELLEKVAEEKAPLPN
                     IEATRRRLSHGLDLTSRLTVGEWLDMWLAGKKGRQSGISRDESNIRVHLKPRIGHYRLD
                     RLRVAHLSEMFEAIAEANVEIAEGNAARRKAFEDLAQIPWKGREPRARRKAMKAAIAEM
                     EPYRRIVGPATRQRVRSTLRAALNAAIAQQLITFNPAAHVELEAGKRPKALVWTEERIL
                     HWKRSGEKPSAVMVWTPEHTGLFLDHVAEDRLYALFHLIAFRGLRRGEACGQKWTDTNL
                     DAGLITVAKQLVVDGWEVYEDDPKTDVGARTIALDSDTVQALKRHRAQQDKDREEWESA
                     WVETGRLFTKENGELLHPANVTRRFIELYEEIDLPPVRLHDLRHGAATLAHAAGADLKD
                     IQEMLGHSSITITADTYTSLLPEADLAIAEAAARLVPRARATSENTAPEAEAEPDDAEH
                     PGPESVPDDADPSGEIPEINSPSAHAPLTQTAPDKESEAE"
ORIGIN
        1 tcgcccaggg catatcggat atgccgcact tcaaggacga cgttgatctg gttcagccga
       61 ccggatcggc ggccgatggt ccgaaaccca ccattctgga gacagcaagc acggacgagc
      121 agctcgttca ggcagcacgc aacgctctgg cgctgggcgc ggaccgtcag gtcgctatcc
      181 tcatgcgcac gagagaccat gagggcaaac tcagatctct ccttgaccga ggccgtgtct
      241 ccgttcgccg cctgcaccgt gatcttgcgt gctggacaga cgaacctggg gtgttctacg
      301 ggacttattc cgcggcgaaa ggcttcgagt tcgactcggt catcctccca ttctgcgatg
      361 cggacgagtt gccgaagccg agtgaggtgg aggcccatgg cttggaggag gccaaggccc
      421 gcgaggcccg gcagttgtac gtggctatca cccgggctcg tacggacctc atcgtgttgc
      481 actcgagtaa gctcaccgat ctgctgccgc acgagatgtc cgatctgtat gtgcgggtgg
      541 gcttgtgaac gacatccttg agcagggccg tgcccgaggg atcacccgcc tatgccacct
      601 caccaagtca gccaacctgt cccacatcct tgacacccgg cagatacgtc ccgtggctgt
      661 cctccagacg gctgccgacg cctaccggcc tgccgacact cagcgcttgg acggcgcacc
      721 ggagttcacc ttcctgagcg tggagtaccc gaatacctgg tacctggcgc aggccgcgag
      781 ccgggaccgc tatttccagg actgggtggt cctcacgctg gacgtcgact tgctcgctgc
      841 ccccggcgcc cggttctccc cctacaactc tgcacgggac aggagcgccg gcgcccggac
      901 cggagcggac ggcttcaacg ctatgtttgc gcctacggtg accggcaagg tgactctgcg
      961 acgagaacgc gggcatccgt cctggtggcc cacggacgat caggcagaga tacagatacc
     1021 cggcaccatc ccgctgtccg ccgtacgcac tgtcatcgtc cgggacgaga agcaggcgga
     1081 gctggagcac ttcaggcatg gccggttcgg catggcggct ctgctgccac ccctggtcgt
     1141 cgctcccgtg ctcttcgaca agtacgccct gagcagatcg gtgcgctccg gtaaacgacc
     1201 actggagacc ccgtacatcc ccggaacaac tctggcagag tgaacacgtg aacgctgagc
     1261 ttcacccatg gaccgacagg gcccgcggca tgctcctcgg ggcagctgtc ggggacgcca
     1321 tgggctggcc ttacgagagg cgggatcgaa cccgctcact tccgccgctt agccaggtat
     1381 cgggtcgatt cttcgcctgg cagcggatgg ctggcagccg attccgtcca attcttgagg
     1441 agatcggacc cggcgagtac agcgacgaca cccagatgct catcgctgtg gcccgcgctc
     1501 gcctcagcgc gggcgacgac tggctcacct ggctgcaacg agtcgagtgg cctttcttcc
     1561 ccgactacga acgcggcgcc ggtgccagcg tcaaacgagc ctgccgtgcc tgggagaagc
     1621 acgaagcggc ttggggccac aggaccgacg accaggagaa gtacttcagc gccggggcca
     1681 acggtgcggc catgcgcatc gcgccgcacg tcatcgttca ccacgagaga cctttcggcg
     1741 acctagctgc agacgtggtc cgcgacgcgg ccacgaccca cgggcacccg cgtgctctcc
     1801 taggcgccct ggtgcacgcg tacgctctgt ggatcagttt gcgacaaccc gcgccgctgg
     1861 cctacggctg gctcgtcgaa gccacgctgg atgggctgaa ggactggcga gaaccggtgt
     1921 ggcagggctt ggaccaacat tggcgcgatg ctgccgccaa ggcgttcccg agtgactacg
     1981 agcgggcctg ggacgacaca gtgcaggagg tggaggacct cctcagcagt gcgcggtcct
     2041 cgttggacag cggtgcgctc agtgcaccct cggcctttct tgaggagcac ggcctgacca
     2101 ggacgagaac ccgtggttcg gggaccctgt gcgcagtggc cgccatctac ctcgcggcgc
     2161 ggtccgctgc cggccccgag cgcggcatgg ccgtcccggc ccgtcaggaa ggcgcagaca
     2221 cggatacctt ggcgtccatg accgccagtt tgctcggcgc aggtctgggt caggaatggc
     2281 tcggctcgtt cggccggacc gttcaggacg gtgccctact catcacgctg gccgagaagc
     2341 tactccgtcc cgtctccgag acactgcccc cgccctcgca cgatgaggtt ggcgaagctc
     2401 ggtcacgatt ccttcatgaa ctcgacggag ccgactctcg agccggtctc ctgctgccgg
     2461 accgccgtca ggcccgcgtc gtcgccggaa ccaccctgac gtctggcaac tggactgcgc
     2521 aacgcactca gttgctcact gcggacggtc agaacctctt catcatccgc ggggtccagc
     2581 gggtggaagc gaaacgcgta caggaggccc cgcgtactga ggtggcacag gccgccgagc
     2641 accggccgtt ccggccggcg acccaagccc gactccaagg cgcctatctg ccggtggccg
     2701 acatcagccg cgttaccgag gccctgactg ctctggggtt gaccgcacca cgccgcggga
     2761 acgactgggt ctcctacgag aacctggtca tcagacaagc ccccgcaggg gaacgggcca
     2821 caggatttcc ggcggcccaa ctccgtgttg ccatctccga cgtccaagcg gcatgggagc
     2881 gcctgcgagc catggagttc gagggagcga tccaaaggga cggcagtgcc ttctggctcc
     2941 gggtcgaccc gcacttgatc gtcgctgtca acaacgctga gtcgcctgcc gggtgacgcc
     3001 agccggtacc gagcctgctc ggatggcccg ggtcaactgc ttgccgacga tcgcaccgat
     3061 gctgcatagc cactcgggag acaggcgggc cacctgaaat gcaccgtgct gccgtggacg
     3121 tttcactgct ctggctgcgt aacagtcggt gaaggtggga cccatggttc gcatacgcgc
     3181 ccatcggcct ctagaccgtg tttgagcaat ttttgccatc gcggttcgta ggagcgttct
     3241 ccggccaagt gctgcaatgc gaaagggtcg ccggcgtcag cggcttggaa ggcaagccgt
     3301 tcggcctccg cgaagtcccc atcatcgaca cacatccaag ccaagttgaa cagggcgccg
     3361 acgtcaccag cgtcgacagc cagttgaaag aggcgcctag actcctcgcg atctcgcaga
     3421 agcgcaattt ctgtcaaatg gctcgtatcg ccagccttgg cggctgcaag agctatgcgt
     3481 tcggcggatt caaggtcacc agcatgttcc cgcatcaaag ccagggaccg caagttgaag
     3541 gcgccagtta ttcccgcttc ggcagcgcgt acggagatac gctcgacgct ctcccagtcg
     3601 tcatcctctc cccgcgagtt cgccaggtgg aacagggcat cagtgctgcc ggctttgaca
     3661 cccagccaag cgagacgttc ggcctcttcg tattttccat cgtcatctcg gttgtcgact
     3721 aggtctctca aggcattcgt gtttccatat cgaatggcac gcaaggcgag gagctctgcc
     3781 tctttgtgct gtcccgattc ttctcgcatg tcagccaagt tcccaagaac ataaggatta
     3841 ccggcttcag cggcccggtg ggctagattt tcggccgcct catattggcc ggattcttct
     3901 cgtatccggg ccaagccgtc gaaagcatcg atgtcccctg cgtttacagc gttctggtag
     3961 aggcgttcag cctccgccaa gtctccggct tccttcgctg cgagggccag acagcgcacg
     4021 gcataggtgc tccccaagtc cgctgcttgc tggaaggcgc gttcggcgct ttcgaaatct
     4081 ccgatctcat ctagcatttc ggctagtgca accatggcgt cgatgtcccc cgcggcgata
     4141 gcgtattcgt atagacgctt cgctcctgcc tggtcgtcgc cgctaaagtc tcgctgttcg
     4201 gccaatgcta ttagagcgtc tgtatttccg gtatttacgg cttgcgagat aagttgttcg
     4261 gccccgtcgt gatctccaga ttcttcccgc atcaggcata gttctacaag ggcttgaggg
     4321 tctcctagct ctatcgccag ctggtagagt cggatcgatt cttctccttc tgcggcccga
     4381 gctagattga ctagtgggtc cgtatttcct gatgctgcga catgcaggag gatctcttcc
     4441 gatccctctc gattgccagc cttttccaag aatccggaca attgtatgag cgcgtttagg
     4501 tctcccatgt cggcagcttt tagatatagg cggaccgaat gctggaggcg caatcgcttc
     4561 tgggcctcag aagcgaggga tgtaaggtca tcagggttgc tgacgtgcag ggctgccgcg
     4621 tcccagaagg tactgggagg cgccttgaat tttcgagctg tccgggcgtc ctgttcgaga
     4681 aagtcggcaa gacggtaatg aggctcatta aacctcgcct tgccggggcg gggacgcatt
     4741 cgagacagtg gtccacgtgc gccgttgaga gggattgctg cgtagttcag tgcctgttgc
     4801 agccaatcat ccgccgattg atcccattgc aggtcggtca ggtagcccgg tgcagccgcc
     4861 tcaagaaacg taagcggtag ggctaaactg tggccgaggc gccgagcatc catggcagca
     4921 tcgatcactg ccttagcggc aggcggcgca ttgcggtaac gctccataag ggctggtgct
     4981 gctgccaagt actgcgtgat gtgaccttgt tccgcattct cggcagcgag tttcagccgc
     5041 gggtcggttt taacggtggc gcggagggta tctagcgctc tctcgctaaa cacctctgga
     5101 acgggtacat cttttcccat catgagggca cgagcttgcg cgtggggatc tgcttttccg
     5161 gaggtaggag aggtagtgag ggtaatccaa tactcgttcc agattgtgcc gagaaccaat
     5221 acaggggcac gcttggggtc tcggagcagt gtgcgcagct tcgaggctac ctgctcgccc
     5281 agggaacttg tcgtcgttag gaggtagtgc tggatctcgt ccagccacac cacggtgtgt
     5341 ggctggatcg cgtctgcgac ggacaggatt tcctgaagtc cgctgggatc aacgggatgc
     5401 cacagtcgcc agtgatttgg gaggctttgt atggcctccc aacaggcgcg ggtctttccg
     5461 gtcgaagatc cccccaccag gattgcaatt ccgctcgctc ctgcagcggc atgctgcgta
     5521 acgtcgcgta gacgttggtc atgatcccgc tcgatgtaga ggggtagttc gggcaggttc
     5581 tcgccgcccg tggatggtga ggcagtgatg gcctgtttca cgctcaatgt gtatgggttg
     5641 gtaacctcgc tgatcggctg tccggttgct tgagcagcaa gtctacggcg ctggagagca
     5701 tcaccttcat gaatgatgat gtccccaccg gcttgataaa tccgagcatt gtccgtcgcg
     5761 tgggcgtctt gctgcacgga ctgccgcccg cggtcgctga tcacgattcg ttgatggttt
     5821 ggttgcccgc agcctggaag attcgggccc gaccggaagc ccgtgcgtgc atctcgactt
     5881 tctttaggct gtcacgtacc gcagcggtca gcagcggcgt gagttcctca tccagtactc
     5941 ggcgtagctc gtctcccagg gtgggatcgt tctgcaaaag ccttcgcagc cgacgttgcc
     6001 agtccgcagc aagttcgctc tctgcctccg cgtctcccga ttctctggca gccaaaacct
     6061 cgtcccggac ctcagccagt tctccctcga tcactgggat ccgctccggg tgcactcgct
     6121 gccacaaggt gactgccgaa gcacgcgcct gctgccaggc atcggtcgcc atcgcgctca
     6181 ccaacgccgt acccacggcc aagaccagcg gttccacaag actcctatcc gcagaagcta
     6241 tgccgtcacc gtaacggacg ggccgtcaca cgaccgagtc attggataga cgttgttgga
     6301 gtacaagtgg caggcccgtt cccacagttg ggatctcggc ggtgattgtc gccgggctgt
     6361 cggccgcgag ggtggggggc atcgatcgcg acgatcctgg agagtgccag tgatggcggt
     6421 caggcgctcg accgagacgt catcgagtac gcaggcgcgc tacctcaatg cgtgccatat
     6481 ggcgcctgtc atcggctggc gcggatcatc acggtgagga ctggtgaggc cggtgacggt
     6541 tggctttgcc cgatgtcctc gtacccccac gactcgtaga gcgcatggac ctttccgtcc
     6601 ccagcggccg ggttgaccat gagcgtgacg tacggttcgt cgcgggtggc gaggagggtg
     6661 tcgtggatgc ggcgggcggt gcctgttttc cgccaggtcg gccggacgcc gatctccttg
     6721 agggccaagg ccggacgctc ggtgtagata tccgccggcg tcgggctggt gcgctgccag
     6781 tagcggtcac cgtgctcgat ggtgttgccg tacgcgtagc cgaccggatg cccatccgcg
     6841 tacgcgagga cggccgtgaa tcccggctcg gtgctgtgcc ggtcaaggcg ttcgccgaac
     6901 gcggtgaccg cgtagttcgg caggtggagg agcggggcgc gcacttcggc gtatacgtcg
     6961 aggaggtcgc cgcgggcggt gtctagggtc gtgaaggtgc gcagttcgat ggcgggcgcc
     7021 gtggtcatgc ggccatcctc caggtggcgg tgtgctcggt ccaggtctgc acggtggagc
     7081 tgcccggcgc ggtggcgcgt agtgcggccc cgaactcctg cagcatgcgc gtgacccgag
     7141 cgtgctgggt ggcggcctcg gcggaaacct tcatcgcggt ggccgtggca gcgtcagggg
     7201 cgccctgggc gagctgggcg tgtgcgagcc gggtggtggc gatggcgcgg gaccggatca
     7261 tgtggggccg gagggcggac aggcagcggt gggcgtggta ctcggcggcc gagtagtctc
     7321 cgagcgccaa gttcgcggag agggccaggg agtccagttc ggcctggtcg tagaaggcga
     7381 gcatccacac cggccggtag tcggcgggat cggcgcgcag catggcgtcc tgcgcctgct
     7441 cgaaggcccg gcggatgccg gtgcggtcct gcgctgtgcc gtggatggcg ccctggcggg
     7501 ccaggccgag ggaggcgaac agggggtctc ggcgggtgag gtgcaggttg cgggcgacgt
     7561 cattggcggc aagcgcgtcg gcggggcggc ccatgtggcg gtacatggtg cccgcgtggc
     7621 tccagatgcg gaacttgatc gcctggtcgc cggacatctc ggcgagggct tgggcctcgc
     7681 gcatgtgcgc cttggcgacg tcgtagcgtc ggccgtcgat ggcggcccac atcgcggagg
     7741 agcggaaggc ggctgcggag gcgtagaggt tgctgcgtac gcgctgggtg gcgctgccgg
     7801 cgttctggag gttgagcgcc tcgtcggcga gggcggcggc ccgctgctcg atgccgagtt
     7861 gtccgccgtg gcggtggtcg ctggcgatga tctcggcgaa gcgcttgttg aggcggttga
     7921 cgtcgctcat gccgatacgg cgcggcgatg cggtgccggg agcggctgct gctgcggccg
     7981 ccgctgcgat gctgccgacg agggtgcggc gcttcatgtc ggggtcctcc tgctgcggtg
     8041 gggccggggt ggacgaaggc cggctccgtg gcacgaaccc taaagcgacg gcgggtagtc
     8101 cggtgacgtc ctcaagtgcc ttgcgggcgg ctgactttgg ccacgtgacc cggcccgctt
     8161 tccatgcccg gaccgatgag ccgtcgagtc ctccagggcg cccggtcaac cgttcaatgg
     8221 ccctgttcac tgcctcggcg aggctgttgg agctgtagcc gtgttcggtc atccacgcct
     8281 caagaacggt gttgcgggtg gtgtccatgc gggcacggta gcccgcgcaa tccccgctcg
     8341 ccaggtaaag gagaggtcaa aacgtcctag gcgagtccgt cggctgagtg cctgaacgtc
     8401 ctaaccaacc tgttgggaaa gggagttgtc tgggtgctgg tcgcccgtcg cgccccaccg
     8461 tgcgggcggc tgttgacggc ccggcctgcc cctgaggttc ccccgcgggg gcgggccggg
     8521 cgccgagacg acacgaaggc tccaccccaa tgacgagtct gagaaaaaca gttgagggtc
     8581 ctctccgtcg gtcaccccac gtacagccag accttcccgt gcgagccgtc cacggctgag
     8641 ctcggccgtc gactcgtccg aggcgtcctc ggcgtgtggc acctcgacgg cctcgccgac
     8701 cgtgccgcgc tgatcattac ggagctgatc gcgaacgcct ccaggcacac tccgtgtccc
     8761 gagatccgcc tcacggttgg gcggccgagc gcgacacgac tgcgtgtcgg ggtcgtggac
     8821 cgggaaccat cgcgtctgcc catactcagc caggcggctg acgacgacga gtcggggcgc
     8881 gggctgctcc tcgtcgatgc cgtcgccgac cggtggggct acgacctgca cggctcgggc
     8941 agacgctctt ggggcaaaga ggtctgggcg gaactccgta ccgagggcgg caagtgagca
     9001 tccccgccac ggcaccctcg ccccttccgg acctcgcccg actccggccc cgccagcaga
     9061 tggccatgga ctgcgccctc tgcgcccggc cgctgggagc gagcggtcga cgactgggcg
     9121 atctacgcca ccggggcctg ccgttccagc tctgggcctg cgctcccaac tgccaggcca
     9181 ccagatcgac tatcccgacc agctgagaaa ggggacctcc ttccatggag tggccgtgga
     9241 tcaccggtga ttgctggctc ggctgcgggc gtacgggagt cctggtgatc tggctcggcc
     9301 cggtgcagtg ggacgggcag cacgcccctt tctatgcgtg cgagccgtgc ctcgatcgcc
     9361 tcaaggcaca ggcgctcgcc tacttcatgg agcggcgacc ggcatccgct tgatcagtct
     9421 cccggcacac gacttcccgg cgtgagagag gcagcccgcg aggacttcct acgcggagca
     9481 cgtcccctcg cgccgggcgg ccaggagccg tcggggggag cagccgtctg gcagcgctcc
     9541 cgtggcggca cctggtgggc gctccagccc agtaacacca caacgattac gaggagttgc
     9601 agcatgacgc gcagcaccgt agttcccagc cgcaccgaag tacgcccgca gatcccgggg
     9661 gcgtcggacg gcttcgacct ggacgtctcc ctcgtcgaga tcgccgatcc ggctggcctg
     9721 gtcaacctga ccgacgacaa ctgcgggtcc acctgcggcg cctgcaccac caacgtcgcc
     9781 tgacccggac tccagatcac ccagagctgg tgccgccgcg tctccgcgcg gcggcaccag
     9841 ccgcccgccc cctcacctac ggaggtactt ggtggttgct ccgcctgcag cgttccgcac
     9901 cggttccact gttctcgtgc gcgccgtggc ccggccctcg ctgccgattc ctccatgccc
     9961 tgacctcgat gaccgctcgc ccagtggttc gtctgcccgt gtgtcgtggc tacgcgcggt
    10021 ctgggcggac aaggacatca ccgaggccct tcagcactcc agcccggtcc tggccgcgca
    10081 ggtacgggcc ctgtgcacgg ccgagcaccc agccctccgg gatgtgcagc gcgcggcgct
    10141 gtccgtggcc cgctacctgc tgcgggccca gcaccgggcg acacccttcg gcctgttcgc
    10201 cggcgtggcc accgcggcgt tcggcccgca ggcgcgggcc gactggggcg aggagcacgt
    10261 ggccgtcggc cgggcagggg cggagtggtt ggcggccctg gtcgcacggc tggagtcatg
    10321 cccggacctc ctcgaacggc tgcccgtcgt catcaacaac accgtgacgt accggggaga
    10381 ccggctcatc gtgccgttcc agcccgacgt taaggacgac cggactcgcg cggtcgaagc
    10441 gtctttggcc ctgactggac cggtgcgcgc agtcctggcc gcgacccggg cgccgattcg
    10501 gttcggcacc ctcgcggaca agctccaggc ggagttcccc gaggccggtc ccgagaaggc
    10561 gcgtcaactg ctggcggagc tgatccggcg gcgggtactg atcacgggcc tgcacgctcc
    10621 gagcaccgag accgatgccc tcgggtatct ggtgggccaa ctcgacgcga tcgacgccgg
    10681 cagcctcgcc ccggtcgccg agaccgtacg cgaactccac gccatccggg cgggcctgga
    10741 ggagtgcgcc acgtacggcg gccgggacag cgtcgcggcg cggatgcgag acctcatccc
    10801 tggcctgcgt cgccaccccg tcgcgctcga cctccgcctg gatgcgcgga tcgttctgcc
    10861 ggaagcggtc gcccgagaga tcgagcgcgc cgctctcgtc ctgacccgat tgagcatccg
    10921 cccgtacggg accgccgcgt ggaacgacta ccaccagcgg ttctacgagc gctacggcat
    10981 cggcacgatg gtgccgctcg cagaggtcgt cgcggacagc ggcaccggct atcccgacgg
    11041 ctacccaggc gctccggccg acgcacgcag accccgcgtc tccgctcggg atgacgccct
    11101 cgtacgactg gctcaggccg ccgcgctcga cggccgtgac gaagtgatcc tcacggacga
    11161 acagattgag gcgctggacg tgggtcccga cgagcctcgg ctgcccccgc acttggagat
    11221 cggggtgcgg gtgcacgcgg tcaacctgga ggagttgcag cgtgggcggt tccggctgga
    11281 ggccgtgagc gtgtcccgtg gcgccggtgt ctccacgggc cggttcctca gcgtgctggc
    11341 ccccgccgac cgggatgccc cggtcgcaga gcttgccgac ctcccggccg cagatggcaa
    11401 caccgtgccc gcgcagctct ctttcccgcc tctgctcccc gagagcgccc acgtcactcg
    11461 cgccccacag gtcctgccca ctgtgatcag ccttcaggag caccgcgtcc cgcaggacac
    11521 cgtcctcacc ccggaggact tggctgtggg gtgcgacggc cgccgcatgt acctcgccgt
    11581 ccctgagcga ggccagcgcg tggaggtcgt tggaatgcac gcgctgaacc tgcgcaccca
    11641 caccccgccg ctggtgcggt tcctcaccga actgtcccgc gcccagtgcg cgcaggtcac
    11701 cgtcttcgac tggggcgccg ccgcggcgat gccgtttctt ccacgtctgc ggtacgggcg
    11761 gacagtactg gcaccggcac gctggaggct ggaagcgtcc gaactgcccg gccatgcccg
    11821 ccctcggacc gagtgggacg ccgtgctcgg cgactggcgt gcccggcgga ggctgccgcg
    11881 ccgcgtccat ctcgttgagg acgatcgacg tctcttcctt gacctcgacg aggccggcca
    11941 ccgtgctctc ctgcgcagac acctcgacca ttcgcgcctg gccgtgctag tcgaggcccc
    12001 ggaaccagag gcgtacggct ggtgcggcgg gcgagcccac gaggtcgtag ttccgctcaa
    12061 ggcaacccga ccgccgacgt ggccgccact gtccgccccc agccgggccc gtgccctgtc
    12121 agcggaccag atacagacac ctgcctcttc ctcagttctt ctggccgccc tgtacggcga
    12181 cccccgccgc caagacatgc tgctctcaca gcacttgccc ggcctcctcg aacaactcgg
    12241 caacccgccg tggtggttca tccgcttccg cgacccggac cagcacctcc gtgtacgcat
    12301 cgccctcccc gacccggaag ccttcgccga cacggcccga acggtgagtg cctgggccga
    12361 tgagctgcgg tgcgtcggct tactggccga tctccgctac cccacctctt accgcgagat
    12421 gggccgctgg ggctccggca ccgcatggga ggcggccgag gaggtcttcc gggccgactc
    12481 gcgcagcatc ctggcccaac tcacgcagcc acaacgtccc ggacagcgca cgctggtagc
    12541 ggcccacacg gtcgccatta cctccgcgtt cctcggcagc accgcagccg ggatgcggtg
    12601 gctgatcgac cacatccctc cgacagcccc cgctcccgtt ccacgcccgc aattcaccga
    12661 cgccgcacgg ctcgccgacc cgagcgacga ctgggtgacg ctgcgctctg tcccgggcgg
    12721 ggacgccatc gtgtcggcat gggctgaccg ggatacgacg ctcgccgcgt accggccgca
    12781 cctgcccggc ccggacaccc agggcatcgc cgtcgacgac gtcctgacct ccctgctgca
    12841 cgtccatttc gtgcgccacg tcgccgtgaa ctttccggag gaggaggtgt gcctctacct
    12901 ggcgcgtgcc gccgccctgg cttggaccgc ccgcaccagg gggagggctt cgtgaccgcc
    12961 cgccccgcgc tcggcctggt cgacgccatc gccgaccggc tcgccgatcc cgacaccgtg
    13021 cccctcggct ccaggacgct gtcctcggac cggcagcacc ttgcttacgg cccgcccgga
    13081 atcgcgctcc ttcacatcga gcgggccgcg agcggcctcg gcccgtggca ccgcgcccac
    13141 gcctggctcg ccgccgcctg tcggcagccg ctcaccagcg gcccggacag ccacccgttc
    13201 tacggggcgc ccgccttcgc ccacgccctg acctgtgccg ccgaccacct tcccggctcc
    13261 taccagcgcg ccctcaatgc gatggacgga cagatcgccg tcaacgtcgg gcgccgtctc
    13321 gatgccgcgc accgccgcat cgacgccgga cgcctgccgc agctcgccga gttcgacgcc
    13381 atccggggcc tcaccggata cggcgcctac ctactgcgcc gaaaccccgg cagctccacg
    13441 atgcgcgccg ttctcgacta ctgcgtgcgc ctcaccgaac cgatcaccca ccatggcgag
    13501 accctgccgg gctggtggac ggagaccggg ccctccggca gcccggacga ccgattcccc
    13561 ggcggacacg ccaacaccgg catggcgcac ggcatcggcg gtgtgctcgc gctcttggcc
    13621 ctcgccgctc ggaacggctc cgtgaccgac gggcaccacg cggcactgca caccatcctg
    13681 acctggctgg accgctggaa gcagagagct gacggcggac cggtctggcc gtactgggcc
    13741 actcaggacg agctgcgcag agggcgtctc gccccgtcag cgccccggcg accgtcctgg
    13801 tgctacggca ccgccggcct cgcccgcgcc cagcaacttg ccgcgctcgc cctcggcgat
    13861 accagccgcc agatcgactc ggagaacgcg ctcgtggccg ccctcaccga ccccgagcag
    13921 gtgaaggcca cgacggacaa cggcctctgc cacgggttcg ccggcctcgc ccacgccgcc
    13981 gcacgtacgg cagacgacgc ccacccctcg accgcgggga aactccgcgc cgcgatcccg
    14041 gccctcctgg ctgcagtcac cccaccggac accgaccccg aactcacggc cacagcgctc
    14101 atccaggacc aggaaggcgg ccccggcctc ctcgacggcg ccgccggcat agccctggcc
    14161 ctccttgcgc ccagcaccgc cgcaccaccc cggtccgcct gggacgcatg cctcctcatc
    14221 gcttgatcca ccgaccgaag gacccttatg cctcccgacc gctggcagca gcacaacatc
    14281 accttcgtcg accgcgagat ggcacggcgc accatcgccg aacgcctcgg tcccgccctg
    14341 atcgaggccg aggccgacgg gcagctcacc ggctggtggt tcatgaacaa gcagccctgg
    14401 ccgctgcgtt accttgccga caagccctca tcagccatcg agtcgctcct gagcgatctc
    14461 atcggcgacg gcgtggccac gttgtgcctg ccctgcgtct acgagcccga gaccgacgca
    14521 ttcggtgggc ccgaggccat ggaggcggcc cacgaactct tccacagcga ctcccgccac
    14581 ctgctcacct accagccgag cccgatgcac ttgggacgcc gggagactgc ggtcctgctc
    14641 gcgagcgcca tgatgcgcgg cgccggactc gactggttcg aacagggcga cgtatgggcg
    14701 aaggtcgcag ctcttcgacc ggtcaccaat ccaccacacc ttgaacgagc cgccgaactg
    14761 atctcgccca tgcagaagtt gatgaccgcg gatgccctca gcctctgccg ccggaacggt
    14821 ccactgcaca ggtatgacga gtgggtcacc gccttcgtac gggccggagc cacgctcgcc
    14881 gacctcgcag cccgcggcgc cctcacccgc ggcctgcgcg ccgtcatcgc ccaccacgtg
    14941 atcttccacg ccaaccgcgc cggtctcctc cggcacgacc agagcgccct gtcccacatc
    15001 gcacgagagg tagtcatggg aacgagtgac cacaccgagt cgcccaccga ggcaacggcc
    15061 gacatcgata gcgtcagcgc ggtgaacacc gacacgacca ccacccccac ggcggacgct
    15121 gagcgtctcc gcaacgccct ggtcgaccag ctccgtacgg acggacacgc ccgcacgccc
    15181 gccgtcgaga ccgcgttgcg gaccgtgccc cgacatgtgt tcgtgcccga cgcgtcactc
    15241 gaagacgcct acgccaacgc acccgtgcac atcaagtacg acaccgacgg cacctccatc
    15301 tcctgcgcct cccagccagg cgtcgtcgcc ctcatgctgg accagctcga agctcagccc
    15361 ggcgagcgca tcctcgaact cggcgccggc accggctaca acgccggtct cctcgcccac
    15421 ctggtcggcg agagcggaca cgtgaccacc ctcgacgtcg acgacgacct cgtggagggt
    15481 gcccgcgtgc accttgccgc cgccgggatc accaacgtcg aggccgtgac ccgcgacggg
    15541 gcactcggct acgccgaagc agcgccgtac gaccggatca tcgccactgt cggcgcgcac
    15601 ggcgtagcgc acgcctggct gcagcagctc gcacccggcg gtcggctcct cgtcccccag
    15661 cgcctcaagg gcacagtctc ccgctccatc gcctacgagc agcgcgacgg ccggtgggtg
    15721 tccctcggca gcgagatgaa caccttcatg ccgcttcggc ggggcatcgc cgacgacgac
    15781 cgccgagtga tccctctcag cacggacggc gccgtacgac tccaggcccc cgccgggctc
    15841 aacatcgacg ccgacgccct cgcaggtgta cttgaccagc cgcacaccga ggagtggacc
    15901 ggtatgacgg tccgtgccat ggagtcaccg gagtggatgg aactgttcgt cacctgctcc
    15961 ctgccctctg gtctgatccg gatgctgttt ccccagagcg ccaagggcac tctgctcacc
    16021 gaggacccct acccctcgtc gaccgcggtc gtcgacaagg gtgccgtcac ctaccttgcc
    16081 cggcgcctgt cgaaggagaa gactcacgac ggcgacaggc tctgggagtt cggcgtcatc
    16141 ggccacggcc ccggcagtga cgaactggtc gcgagggtcg ccgacgccat ccgcacctgg
    16201 gatcgcgact accgcgaccg tgaggccacg ttcgagatcc agccccttga cgcccccgag
    16261 atcgagcagc gccccggtct cttcgccctc gataccccgc tgaaccgcat cgtcgtcgac
    16321 tggcgatgac gccccacccc tagcggacgg tgcccgtcgg cacacgactg gcgggcaccg
    16381 ccgcctcagc agtcctcact ctcgacccgg gggatccatg gacccgcacg gcctcacagc
    16441 ccagcgcttc ccgctcgtcg cccgattccg ccccgcctgc ctgcccctgc ctgaacgcgt
    16501 acgcgcactc gtcgacctgg ccgacaccgc agtgaagaag gccgaccagg ggctcgcatc
    16561 ggccgtctac aaccaggccg cgctcatcgc ctccgacctc gacctccccg acctcgcccg
    16621 cgagatgtgc caccagcacg ccgccgccta cctccacgcc tgccccctgc ccggcatgag
    16681 cgcgatccga ggactggaac cggtcgtcaa cctcgcccgc ctccagatcc gcgctggcca
    16741 cgccgatgag gggcgccagc gactcctcga cctgtacaag gccgtcgaga cgggcacagc
    16801 ggcacggttc gagggcgtca acgtccctgc ggacctcaca gcgaccggcg aagaccgcca
    16861 ggaagttcgc gcgtggctgt ggcgcgtcct cctcgccgac ggcacgcgca ccctcaccac
    16921 cgaggggcga tgggccgagg ccctggcgca catcgaagcc caccatggca tcggacagcg
    16981 gatgctcgac ggtcggcagg tcgccgtact caccgccctc gttgcgaacg acacggcagg
    17041 ggcggctggt ctcctcgccg acacgatgcc cggcgacccg tgggagcaag ccgtcacggc
    17101 atgcctgacc gtcctgtgcc gcagcgacgc cgggcagccg atcgacagcc acctggccga
    17161 cctgctcacg acctactccg gacggaaggc cgaacccggg atgaccgtct tcgacacccg
    17221 cctcggactt accgtcctcg acgcgatcgg ttccgccgag gcgctcgccg cgcactgcat
    17281 cgtcgaggac ctccaccgca ggacgacgga cgccgaggac ggctacgcgg cccgcgagaa
    17341 cttggctcac cctcggttca ccgagatcgc cacggaccgg caagtgcagg actgtcgcgc
    17401 gctggcgagc gcctgcgccc tcggcacagg ggtcctcccg gacgaactgc gaggagaact
    17461 gacgtcggct ctgcgcgcca gcgacagcgt gatccgggaa agcctcacac gttcctccga
    17521 tcccggacga acgcaacccc tgcgggcctg acagtgccta tcggcgctgt cggcgctgct
    17581 gttcggtagg cgtcgtagca gccgacggaa actgaccgtc gtggctctgc cggacgcgga
    17641 ccgaggctgc gagggtggag cggcgacggg cggcttcggc tcgccgattg ggtgccgggt
    17701 tgcggccggt gtgctggatg cgggtgatga gcacgcgggc gggttggagg gcggtggtca
    17761 actcgcgctg agccgcggct tcccgaagga gttggtgggg ttggtggccg cgggcttccg
    17821 cgtcggcgag gacggtggcg agcgcgggcc aggccgggtc ggtgaggatg cgctcagcgt
    17881 ggtcggggac ggctgcccgt acgtcgccag ccagaatgcg gctggcttca tccctgggcg
    17941 gtcgggcggt gagttcggcg agcgtcgggg cgagggccag gtcggcggct gtctggaggt
    18001 gctggacggc ctggcgggcg gcgtcggcct ggtgggcgtg gtgcttcgct tcgtgccagc
    18061 gcgcggcgac gatggtggcc cagacgaggg ctgcgaccag agcggccagg gcgctgccgt
    18121 ccgggccggt ggcggtgtgg acgatgtcgc gcgccgcgcc gcgcagggcg agggcggcac
    18181 ggtcctcggc ccggacctgg gaacgctggg cccgggcgaa cgccttggaa gcggcctgga
    18241 gttcggcgcg cagaggggca ggtaccttct gggcggtagc ttccaggagt tcgccaaggg
    18301 cggtgatgtg ggcctgggcg tgggtgtcgt cggccagatc ggtgtggagc atgtcgaggg
    18361 cgtcggcggc ttggtgccag ggggtgctgg ggtgtttgcg gcgggcggtg gggtgttctt
    18421 cgggccggct ggattcgagg cgggccttga ttttgggcag agagaggtcg ggggcgatct
    18481 tgcttccggg gtggtagatc tgctcgccag cctcgttgac gtcgccgggt cggccggcgg
    18541 catatccgag gaggtcgcct gacgggccgc gcctgacctg gacctcgacg ccgctggctt
    18601 gcaggtaggc gatgaattcc tcggcgctgg tcacatgggg gatggcggca cggatgcggt
    18661 cctggagcca ctcggcgctg ggctggtccc agccgaggcg ttcggccttg tgcatctcgg
    18721 cctgagtcgg gcgacggctt ccggttccgt cccccttctt caactgccgt agcccgtagt
    18781 ccttctcgat ctcgcggcac tcgtcaccga cgcgcacgcc gctgccgtgg agtttgggac
    18841 ggcggccgtc ttcgcggacg gtggtggcga ggatgtgaat gtggtcatcc gcgtgccgta
    18901 cggcgatcca gcggcagccc agatcatcac cggtcggcgc gataccggcc gcttcaacga
    18961 tgcgctgggc gatctcgccc cactcggcgt cggagaggta acggtcctcg ggggcggcac
    19021 ggaccgggca gtgccacacg tggtcggtga cctgtttgcc gaactcgccg ttgcgcagcc
    19081 gcacgggctc gtcgaggtag cgggcgagtt cggtgagggt ggcgttctcg tcgcggccga
    19141 ggtcgggcaa gccgagcatc gcgaacccgg ccacgatgtg cgggtcgagg tgttcgtcgt
    19201 ggtcgccggg gccgtagagg taggcgagga ggccgcgggt gttggacccg gccggtttga
    19261 tggcggcgat cacgcggctg cctccgtctc cgggtcggcg ggctggcgca gggcttcggc
    19321 gatcagctcc agcaactggt ggagttcggt caggcgctgg cggatgtcgg gtggggtgtg
    19381 gtcgctgttg agggcgcggg cgatctggtt gacgttgacg ccgatccggt tgagctggcg
    19441 caggacctgg gcgcggaaga cgtgggtgcg gcggcggtcc tcggacaggg gcaggttggc
    19501 ggtgaagtgg ccggtgatga aggcgaggac gatgtcggcg gcgaagcccg agtcacccct
    19561 gtagccgtgc tcggcggcag tctcctggag gcgggtgtgc tcgtcgccgg tgaagcgcag
    19621 cgggccgacg cgaacgacgc gcttggtgcc ggtgaaacgg cggatcgtgg gctgcacgct
    19681 cttcacgaca ggctcaccgc cgacgctctc ggcgatgtcg acggcacgta cgcggcgcag
    19741 agtctcgcac tggagggtgt ggagcatgtc ctcgtcggag ccgccctcgg ccccgacgcc
    19801 ctggcctggc gccccctggt gctgggccgt ctccgccacc cccggggcgg agaccaccga
    19861 agaccggcct tgagtcggac tcggggtact actggctccg cctggggcag ctcgtccgaa
    19921 cgcgcgccgc caacggtcca tcagcgtagg cgacttcgtc agcggcagcg gctcgtcggg
    19981 ggcgttttcg ggggcgagcg ggttgtgagt catggacggt tctccagagc ggggtcggga
    20041 gggcgtgcgg ggcacggcgg agatcaggcg gagttcggac ggctgccgcc tcatccacag
    20101 gtgggggcga tcgcgcgatt cttgggaggc ggtatggcgg gccgggtgac cggaagggtt
    20161 ccggtcaccc ggcagcggtt gcggtcagcc gctggaccga tgggtctcgg ctgcggcatc
    20221 gggttcggcc cggaggaggt tcatcacctc ggtcagccgc ttgctgccga ccgtcagccc
    20281 tttgtcctcg accgccgtcc ggactacggc ccgggtgagc ttgccctgct cagcggcagc
    20341 ggcccggccg atctccacga gttcctcaag gggagccccg ggcggacggc caccgcgcac
    20401 cttgcccgcc gcggcggagg cgggcggttt cggagactgg acggatacag cggccgacag
    20461 cccagcggcc tggacgggct cagtcaatag ctcggcaggc ccgaagcgcc cggccggaac
    20521 ctcgccggac cggccgaccg cgatggccgg cgcctcggcg aggtggacgg atgtggtgac
    20581 cgacggttcc ggcacctgca ccgaatcggg gcccgattgg tcgacatcag gctgtgcgac
    20641 gagttcgtgg atctgccgca tcagcacgcc gaaggccacc atcgcggcgg ccgggggaac
    20701 cgcggcgacc acgtagtcga gcaatgagac gctgccgacg tcgcgcgtgc cggtcacccc
    20761 ggccacgttg agcccgatgg agccgaatga tccgatggcg gtgacgccga tggcccacgg
    20821 gtcggtgacg cggcgcaggc ccgcgcggag catgaggagt tcgcccgcga cgatgaacgc
    20881 gtccagcgtc gcgggccacg cccatcggcg gatcggagag tcgcggagtc cgtgctgggc
    20941 ggcgacctcg gccaggtggg cgtaggagag ccagaacgca ccggcggtaa gggccacgat
    21001 gacgatgccg gccgcgcgga gcacgtactg ctccgcggag agcttcgcct tcgctggttg
    21061 cttctcaccg ggctggtcgc cgcgcggcgg gcggtctcgg cggcgggaca tgagagggac
    21121 cttcaagcgg ggggtgctcc tgggctggtg gtgtggtgcg tctttgccgt cttggccgtt
    21181 gcaagcgcag gtcacagcgt gtacggcaac cgcctcggcc ttccgtcctg gcgtgtgccg
    21241 ccgacgtctt gttccgagtc ggaacaagac gtcgacgcgt cctagcgggc ctggttccgg
    21301 tgcggcagtg ccccgggccg ggacggtggc cttgtgcctt ccgtcctggt gctcggtgct
    21361 ttgacctgcg ctgatacggc aggacggcgg gggacggcgc aagacggatg cgggcggcgt
    21421 cttggcggta gggctgccat ggcggatcgc gttgccgtct tggccccggt tgccgtcttg
    21481 ccggtatgcc gtttgacctg cgagatcacg gcagggacgg cagggacggc aacaaggggg
    21541 cggggttcgg cccgcgtcga gttcgccggg cagggcgttc actcagtgaa cggcgggtgg
    21601 ttcaccgggc gggccgcctg ggggtccact gagtggacgg tggggcagta ccggctccag
    21661 gcatccagga acttgttgcg catgtagccc ttgcgctggg tccggtcggc catgcgcacg
    21721 ttgccgggcc tgatctcgaa ctcgcgcagc atcctgccca gttcacgggc ggtcagcccg
    21781 ccccgccccc actccgccca cggcgcctcc gcgtcctggc gcaggtgatg gaggagttcc
    21841 tcggtagaca gactgtccac ctcacgctgg gcgtggaaga cccggcggat gtcggcgagg
    21901 atccgcgctc cgctcgggtg ctcttcctcg gccgccactt cggcggcgac catccgcgcg
    21961 cacgcgaggc gcgccaggcg tggccagcgc ccgccggcga ggtcggcgac gataaccagg
    22021 ggctcccagg tgtccgcggc acggtcctcg accggcatgt ccggctccag gttcgccgcc
    22081 tcgtccagca gcggccgggc ccacgcggcg atacggtcgc gcaggtcatg cagggccggg
    22141 atgtcgcggc gggagcggaa gggcttgacc ttctcgccct cggcccggcg ccgcatgcgg
    22201 atcacgaccg accggtccat gaccgtgtcg ggcagctcgc cgattcccgc gatggccgcc
    22261 atggcgaagg tcgcgaagcg gtgcggggtg tggtcgttgc ccacgacccg ggtcacgtac
    22321 cgccctcgct ggtggccggc gttgagcagg ccgcgcgtct cctcgttctt ctccgcgacc
    22381 ttcgggccga agatggtgtc cgcctcgtcc accaggaggg ttggcgggtt gtcctcggag
    22441 atcgaccgga agatggccgc cggggtggtg ttgatggtga gcatcggttc gtggaccgtc
    22501 tcggtcagca cgtccagcag ccgcgacttg ccgcacctct tcgccgggcc caccaccgcc
    22561 aggcgcgggg cgtgctgcca tgcgggctgc aggtgcgtcg ctgccaccca caaggtgatc
    22621 gcgtcgaggg cctcctgaga gggcgggatc acgaactggg cgatctgccc gcgcagttcg
    22681 tccagcaact cggagccgta cgtcggctcc gcatcggata tttcctccgg cccgctcggc
    22741 gtcttcgcct cgtcggtgct gcgggcatct gcatcactgc cggggctcgg atcggcgtcg
    22801 tcggcctgcg tggcgtgcag gtgggcgccg ggtcggccgg ggatggccgc cgcgggccag
    22861 atggcctgcg cgggggcgga atagggttcg gggttctcgg gttgcactcg gcagctcctc
    22921 gtctggcggt ggcgggctcg cacgcccttg ccgccgggtt ggttcttcca gggccgttcg
    22981 gggttgctcc gccgggggcc caccctcttc tcgcgagcgt tcggtgatcg cgagggaaca
    23041 cggaccgtac gtccacgcct ggccacagtc cagcgtttct gtgtcagctc agcgcagaac
    23101 ggtctgctac ggttccccgc tctcacgcgg ccaggcccag cagggccaac aggtctgcgg
    23161 tcaccacccg gtaggcgttg cccagccgca gcaccttgca cgggtactgg ccgcgcttcg
    23221 ccagctcgta ccccttgctt cgcccgagcc ccagcgcccg gttgcctgtc tccaggtcaa
    23281 cggcggcggg aagctccagc agctcctcgc ggctcatgcc cttcacccgg ccggcgagtc
    23341 cgttctcgcg catacgcgct ccatccatga ctgagccctc ggcgaacacg acgatcacgc
    23401 tcgtctccag gccatggaat caacggtagg gaagttaatg tgtcttcatg acacaacacg
    23461 gtttcgatgc tggaagggac gaggacgacg tcccggagtg ggtggaccaa gtgatggcca
    23521 ccgtggccgc cgaggtccgc agacgaagga aggagttgca catgagcgcc caggacctgg
    23581 ccgaccgctg cgaggagatc ggccacccga tcccgcgcaa cgtgatcgcc aacatggagt
    23641 ccggccgccg cgccaacctg cccctggtcg acgtcatcgt cctcgccgaa gccctggaca
    23701 cctacccgat ctgcctgctc taccccgtcg gctacgtcga ccgagtccag cgcctccccc
    23761 tgcagcactc cgaacggacc tgggatgcca tgcgctggtt caccggcgac agggaggagc
    23821 tcggcaggga agacgccatg ctccggtcct tccgcgccca catccgccac cagcgcgccg
    23881 ctctggccgc cctgaaaggc gagaagcacg agcgctggaa agcggagaca gcacccaaca
    23941 aagccgaacg cgaggaagcc ctcctcgccc aagccgacta cgcggaaagg gtgttggaag
    24001 ccaagtaccg gcttcgcagc gcccgcgcct tcatccgcga agacggcggc acaccaccgc
    24061 acctgccgcc ggaactcgcc gatgtcgacc cacccgaaac cgcccccaac accaccgagg
    24121 agaacgatct ttgaagggtt ccacccaccg ccgctgctac tgccgcgacc cccacaccgg
    24181 caagccgctc ggcaagaagt gccccaagct ctccagccgc aagcacggct cgtactccat
    24241 acgccaggag ctcccgcccc gcgaagacgg cacccgccgc tccttcagcc gcgccggcta
    24301 cgactccctc aaggccgccc aggtcgacct cgaccacgta cgcgctctcg tcggcctcgc
    24361 cgacgccgat gacgccgagg gcctggccca gatagccgag ctgctggaga aggtggccga
    24421 ggagaaggcc ccgctgccga acatcgaggc cacccgcagg cgcctcagtc acggcctgga
    24481 cctgacgagc aggctcacgg ttggcgagtg gctggacatg tggctggcgg gcaagaaggg
    24541 gcggcagagc ggcatcagcc gggacgagag caacatccgc gtccacctca aaccacggat
    24601 cgggcattac cggctcgacc gcctccgggt cgcccacctg tcggagatgt tcgaggccat
    24661 tgccgaggcc aacgtcgaga tcgcggaagg caacgcggcc cgccgcaagg cgttcgagga
    24721 cctcgcccag atcccctgga aaggccgcga gccccgcgcc cgccgcaagg cgatgaaggc
    24781 agccatcgcc gagatggagc cctaccgccg catcgtcggt ccggccacac gccagcgcgt
    24841 ccgctccacc ctgcgggccg cactcaacgc tgcgatcgcc cagcagctca tcaccttcaa
    24901 cccggccgcc cacgtcgagt tggaggcggg caagcgcccc aaggccctcg tatggaccga
    24961 ggagcgcatc ctccactgga agcgcagcgg agagaagccg tcggcagtga tggtctggac
    25021 gccggagcac accggcctct tcctcgacca cgttgcggag gaccgcctgt acgcgctgtt
    25081 ccacctgatc gcgttccgcg ggctgcggcg gggcgaggcg tgcgggcaga agtggacgga
    25141 caccaacctg gatgccggtc tcatcaccgt cgccaagcaa ctcgtcgtgg acggctggga
    25201 ggtgtacgag gacgacccca agacagacgt cggcgcgcgc accatcgcgc tggactccga
    25261 cacggtccag gccctcaagc ggcaccgcgc ccagcaggac aaggaccgcg aggagtggga
    25321 gagcgcctgg gtggagaccg gacgcctctt caccaaggag aacggtgagt tgctccaccc
    25381 cgccaacgtc acgcgacggt tcatcgagct gtacgaggag atcgacctcc cgccggtccg
    25441 gctccacgac ctccgccacg gtgccgcgac cctcgcccac gcggccgggg ccgacctgaa
    25501 ggacatccag gagatgctcg gccactcctc gatcaccatc acggccgaca cgtacacgag
    25561 cctgctcccc gaagcggacc tggcgatcgc cgaggccgca gcccggctcg tcccgcgcgc
    25621 ccgcgccacc tccgagaaca ccgcccctga ggcggaggcc gagcccgacg acgcggagca
    25681 tcccggcccg gagtccgtgc cggatgatgc tgatccgtcg ggagaaattc cggagatcaa
    25741 ctctccgtcc gctcacgcac cgctcacgca aacggccccg gacaaggagt ccgaggccga
    25801 gtaggagccc tccctggggg agaaacccca ggtcagagcg gttatgcgct gtgcccccgg
    25861 caggattcga acctgcgaca cccgctttag gagttcgatc cgctcccgct ccaactggtg
    25921 tcggcgactg gggcgacggc tggccagaat cgcgggtgta cgcctccgtc cggcgtcgtt
    25981 gatgtcaggc gtggatgtcg ggcgtctgct ggatagaacg gatgctgagg cggtagcgag
    26041 cccaacagga gcggggcgcc acctaccagc cattcgccaa ccgatcaggc cgcagtgagc
    26101 tgtggcgacg gtggaccggg tctgtgaagg ggggctgctc aggggcggct tgcagcgagt
    26161 gtccgctggg tccactcagc aagctggcga gtcaccttgc tcgaccggcc ggccccacct
    26221 tccgtgaacg gcaacaccac caacgcagga atgcttgcga tcgtcacgag aatcactggg
    26281 attagacaca aagcgaccag taggacgcgc tgtagcgcac gcgatgctg
//
