LOCUS       NZ_CP033073            11848 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces dangxiongensis strain Z022 chromosome, complete genome.
ACCESSION   NZ_CP033073
VERSION     NZ_CP033073.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces dangxiongensis
  ORGANISM  Streptomyces dangxiongensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     The genome of Streptomyces dangxiongensis Z022
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8085191)
  AUTHORS   Zhang,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) State Key Laboratory of Cryospheric
            Sciences, Chinese Academy of Sciences, Donggang West Road 320,
            Lanzhou, Gansu 730000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. version 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 213.0x
            Sequencing Technology             :: Illumina and Pacpio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003675325.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:16:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,241
            CDSs (total)                      :: 7,151
            Genes (coding)                    :: 6,614
            CDSs (with protein)               :: 6,614
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 537
            CDSs (without protein)            :: 537
            Pseudo Genes (ambiguous residues) :: 0 of 537
            Pseudo Genes (frameshifted)       :: 320 of 537
            Pseudo Genes (incomplete)         :: 281 of 537
            Pseudo Genes (internal stop)      :: 26 of 537
            Pseudo Genes (multiple problems)  :: 83 of 537
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:47:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1866322
            Orig. end                         :: 1878170
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP033073.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Binglin Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11848
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11848
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11848
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6848](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6848)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            125..562
                     /locus_tag="D9753_RS08240"
                     /old_locus_tag="D9753_08240"
     CDS             125..562
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547247.1"
                     /locus_tag="D9753_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08240"
                     /product="ATP-binding protein"
                     /protein_id="WP_121786408.1"
                     /transl_table=11
                     /translation="MHERSARPASWRIALPHTTAAVPVARALVRTALAEVEHVTDCDTA
                     ELLTAELVANAVEHTAGRGPIELVVELAPTGCQVEVHDPDPAPPGHLTRPVIEEPDVWE
                     EGGRGLLLIRALSSSCGHRPTPSGKAVWFRLPVVPAQRRPA"
     gene            complement(522..1970)
                     /locus_tag="D9753_RS08245"
                     /old_locus_tag="D9753_08245"
     CDS             complement(522..1970)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019984133.1"
                     /locus_tag="D9753_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08245"
                     /product="amino acid permease"
                     /protein_id="WP_121786409.1"
                     /transl_table=11
                     /translation="MPAPRIKSPHLLVAESGADREGHGLKRTMGLFQLICFGVGAIVGT
                     GIFVGLSDSVAQAGPAVVVSFILAALTCVFTAFSFAELGGAIPVSGSSYSFAYADLGES
                     TAFLVGWCLLLEYGISISAVAVGWSQYVNELLHSLTGWQLPAALSAGPGDGGAVNLPAV
                     IVIGMASVLLVRGVRESARATAAMAAVKLAILLAFCAIGYSAFKDGNLTPFSPAGLGGI
                     GAGTTAAFFSYIGFDAITTAGEEAKNPRRDVPVAILVCMGLVTLLYCAVAVAAIGAVGG
                     DQVAGRPAALSYVVNEVTGSAVGGGVIAFGAVVAIASVVLAVMYGQTRILMSMSRDGLV
                     PAVFEKVSPRTSTPVAGTLIVAVVFAVPAAFASLDAVMNLCTIGTLAIMAVVNISVIAL
                     RRREPGLTRSFRVPLYPVAPLLGVGFCLYLMYETGWRTWIQFAVFLAAGLLVYGAYGRR
                     HSTLATAAPDTVTPDAAEREPQAV"
     gene            complement(2071..3078)
                     /gene="argF"
                     /locus_tag="D9753_RS08250"
                     /old_locus_tag="D9753_08250"
     CDS             complement(2071..3078)
                     /EC_number="2.1.3.3"
                     /GO_function="GO:0004585 - ornithine carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445226.1"
                     /locus_tag="D9753_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08250"
                     /product="ornithine carbamoyltransferase"
                     /protein_id="WP_121786410.1"
                     /transl_table=11
                     /translation="MATVPTALAGRHFLKELDFTEEEFRGLVELAAELKAAKRAGTETQ
                     HLRGRNIALIFEKTSTRTRCAFEVAAADQGAHTTCLEPSGSQIGHKESVRDTARVLGRM
                     YDGIDYRGDSQAKVEELAAHAGVPVYNGLTDDWHPTQMLADVLTMTEHSAKPLRKIAFA
                     YLGDARFNMGNSYLVTGALLGMDVRIVAPKSYWPAQEIIDRAHDLAASSGARITLTEEI
                     ADGVAGADFVATDVWVSMGEPKEVWSERITALAPYAVTMDVLRATGNPDVRFLHCLPAF
                     HDLGTEVGREIHERHGLTALEVTDEVFESAHSVVFDEAENRLHTIKAVLVATLA"
     gene            complement(3141..4364)
                     /locus_tag="D9753_RS08255"
                     /old_locus_tag="D9753_08255"
     CDS             complement(3141..4364)
                     /EC_number="3.5.3.6"
                     /GO_function="GO:0016990 - arginine deiminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006527 - arginine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125172.1"
                     /locus_tag="D9753_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08255"
                     /product="arginine deiminase"
                     /protein_id="WP_121786411.1"
                     /transl_table=11
                     /translation="MGFHVDSEAGRLRRVILHRPDLELKRLTPSNKDALLFDDVLWVRR
                     ARAEHDGFADVLRDRGVEVHLFGDLLAETLALPEARALVLDRVFDEKEYGPLATDHLRA
                     AFDGMAPPELAEALVGGMTKREFLDAHAEPTSVRFHVMDLDDFLLPPLPNHLFTRDTSA
                     WIYDGVSINAMRRPARQRETVHFEAIYRHHPLFHGETFHVWSRGQADYPSTIEGGDVLV
                     LGGGVVLIGMSERTTPQAVEMLAHKLFAAGSARTIVALDLPKRRAFMHLDTVMTMVDGD
                     IFTQYAGLGMLRSYTIEPGVGERELKVTDHPPEHMHRAIAAALGLGEIRVLTATQDVHA
                     AEREQWDDGCNVLAVEPGVVVAYERNVTTNTHLRKCGIEVIEIPGSELGRGRGGPRCMS
                     CPVERDAV"
     misc_feature    complement(4419..4435)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.12"
                     /tool="antismash"
     gene            complement(4465..5004)
                     /locus_tag="D9753_RS08260"
                     /old_locus_tag="D9753_08260"
     CDS             complement(4465..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675583.1"
                     /locus_tag="D9753_RS08260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08260"
                     /product="DUF5825 family protein"
                     /protein_id="WP_121786412.1"
                     /transl_table=11
                     /translation="MSGLPGTVPHRLTGRRVETAGPLDLSGSGRGTAEAVRFLRECQSL
                     GLRVDWRATGTPAYDPALLYHLPPPTSPPAPAGGPADWRPAYGHGVLYHRRGPDFVTVL
                     DRRERGTAVRLTLDHPALVATFLRLLEPTPVDALDAAGHEALGPLVTERLVLSAGGWAV
                     SLPPRIGRWPVPCTAI"
     gene            complement(5001..6848)
                     /locus_tag="D9753_RS08265"
                     /old_locus_tag="D9753_08265"
     CDS             complement(5001..6848)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675582.1"
                     /locus_tag="D9753_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08265"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_121786413.1"
                     /sec_met_domain="TIGR03975 (E-value: 3.5e-162, bitscore:
                     539.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVHLVTMPWHPLDLPSLQLGLLNRIVRQARPGDEVTEFHGSLRW
                     AEFLLERTGGRLLPGDCVEVGSDGIFHGLGDWVFSGVLHDDPGWGLARLRDYAAGRDVR
                     IDTAVAMRPHAAPFVDACATEVLAAEPDVVGFTSTFMQNVPSLALARELKRRRPQLAVV
                     LGGSNCDGPMGHALHRNHRFVDHVVRGEAEYALPALLRHLAEGTAPADVPGLCWWDGTT
                     ARANPETRRTVAPADIPSPDYDQWQAALDASPVREHVHPKLVVEGARGCWWGERHHCTF
                     CGLNGTAMEFRAKPGERLWAEIDRLVRRHRLLDVVTVDNIIDMAYFRDFLPRVAGSGWD
                     LRLHYEVKSNLTPDQLRLLAASGTVHIQPGIESLGSRVLDLMDKGVTGARNVRTLRECE
                     NHALTCSWNLLYGFPGESADDYTPVIDQLPALVHLQPPSGAHRIQLERFSPHFTDPRLG
                     FGKRRPAEMYQHVFDLPEEELADLVYLFDADDAGITGPAERRLRAAVAAWRAGHAHSRL
                     LFEEDGPDLLVHDRRHGRPPAGHRFTGWRAAALRRLEDGRTVPALHRLLAADGHEVPSG
                     ALADWVDEVLRLGLLFRDGATYVALPTWGEPVRLPEGAG"
     misc_feature    complement(6249..6251)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6261..6263)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7041..9584)
                     /locus_tag="D9753_RS08270"
                     /old_locus_tag="D9753_08270"
     CDS             complement(7041..9584)
                     /GO_function="GO:0004113 - 2',3'-cyclic-nucleotide
                     3'-phosphodiesterase activity [Evidence IEA]"
                     /GO_function="GO:0051731 - polynucleotide
                     5'-hydroxyl-kinase activity [Evidence IEA]"
                     /GO_process="GO:0042245 - RNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675580.1"
                     /locus_tag="D9753_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08270"
                     /product="polynucleotide kinase-phosphatase"
                     /protein_id="WP_121786414.1"
                     /transl_table=11
                     /translation="MTGTRTGRVLPVTDLSLVVLVGASGSGKSTFARRHFKPTEVLSSD
                     FCRGLVCDDENDQSASGDAFDLLHYIAGKRLAAGRRTVVDATSVQQDSRRQLIELAKKH
                     DVLPIAIVLDMPEEVCAERNAARTDRADMPRRVIQRHIRELRRSLRHLEREGFRKVHVL
                     RGVEEAENATVVTEKRFNDLTHLTGPFDIIGDVHGCSAELESLLAELGYADGVHPEGRT
                     AVFVGDLVDRGPDTPGVLRRVMGMVKSGDALCVPGNHENKYGRHLKGRTVRHTHGLAET
                     VAQMAGESEEFRAEVRRFLDGLVSHYVLDGGRLVVCHAGLPEKYHGRTSGRVRSHALYG
                     DTTGETDEFGLPVRYPWAEDYRGRAAVVYGHTPVPEATWLNNTICLDTGAVFGGKLTAL
                     RWPERELVDVPAQRGWYEPAKPLRSEAPGGHDGRPLDLADVHGRRAVQTRHAGRVAVRE
                     ENAAAALEVMSRFAVDPRLLPYLPPTMAPTATSAVDGYLEHPEEAFAQYARDGVARLVC
                     EEKHMGSRAVALVCRDADVARTRFGVAGGPTGALYTRTGRPFFDDGQTTEEILGRLRSA
                     VTDAGLWDELATDWLLVDAELMPWSLKAAGLLRSQYAAVGAASGAVFPDALAALEAAAA
                     RGADVGGLLARQRERAGDAAAFTAAYRRYCWTTEGLEGVRLAPFQILAAQGRSLAALPH
                     DGQLALIDRMVEHDGSGLLGTTRRLYVDTGDPESVRAGVDWWLEMTGRGGEGMVVKPVG
                     ALVRGGDGRLVQPGLKVRGREYLRIIYGPEYTRPDNLARLRRRFLTHKRSLALREYALG
                     LEALDRLAEGEPLWRVHEAVFGVLALESEPVDPRL"
     gene            complement(9581..11062)
                     /locus_tag="D9753_RS08275"
                     /old_locus_tag="D9753_08275"
     CDS             complement(9581..11062)
                     /GO_function="GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042245 - RNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033815.1"
                     /locus_tag="D9753_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D9753_08275"
                     /product="3' terminal RNA ribose 2'-O-methyltransferase
                     Hen1"
                     /protein_id="WP_121786415.1"
                     /transl_table=11
                     /translation="MLVTISTTGAPGSPATDLGYLLHKHPDKAQAFSTSYGTAHVFYPE
                     ADAERCTAALLLEIDTVALVRRGKGKGRGGAPDAALAQYVNDRPYAASSLLAVALSNVF
                     SSALRGVCAARPERATTPLPLRVGIPALPARGGAGLVRRLFEPLGWSVTADPVPLDTTF
                     PEWGDSRYVRLVLESRTLTLAEALRHLYVLLPVLDDAKHYWVSADEVDKLLRAGEGWLA
                     GHPEQELITSRYLSRRWSLTRQARERLELVRLAEADDSEVEDIDNAVAQDTGAEAEEKP
                     APLAVRRREAILAALRERGAARVLDLGCGQGQLVQELLKDARFTEVVGVDVSVRALSIA
                     ARRLGLDRMGERQASRVRLVQGSLAYTDNRLKGYDAAVLSEVIEHLDLPRLPALEYAVF
                     GHARPGTVVVTTPNVEYNVRWETLPAGRVRHGDHRFEWTREEFRAWAEAVAGRHGYDVA
                     FTPVGPGDPAVGPPTQMAVFTRTTATDEKKEAKAA"
ORIGIN
        1 gcgacaggcc ggtgtcgtcg cggccggggc cccggggcga tgcccggcga cggcccgcgg
       61 ggccgggccc gtaccatttc ctacagtcga aagcaggaca gcctgctcca cgaacggact
      121 cgccttgcac gaacgctccg cccgaccggc ctcctggcgc atcgcgctgc cgcacaccac
      181 ggcggcggtg ccggtggccc gcgccctggt gcgcacggcg ctcgccgagg tggagcacgt
      241 caccgactgc gacacggcgg agctgctcac ggccgaactg gtggccaacg cggtggagca
      301 caccgccggg cgcggcccga tagagctggt ggtggagctg gcgccgaccg gctgccaggt
      361 cgaggtgcac gatccggacc cggctccgcc cggccatctg acccggccgg tgatcgagga
      421 gcccgacgtc tgggaggagg gcgggcgcgg actgctgctg atccgcgccc tgagttcctc
      481 gtgcgggcac cgccccaccc cgtcgggcaa ggcggtgtgg ttcagactgc ctgtggttcc
      541 cgctcagcgg cgtccggcgt gaccgtgtcc ggcgcggcgg tggccagcgt ggagtgccgg
      601 cggccgtagg cgccgtagac cagcaggccg gccgcgagga acacggcgaa ctggatccag
      661 gtccgccagc cggtctcgta catcaggtac aggcagaagc cgacgccgag cagcggtgcc
      721 acggggtaga gcggcacgcg gaagctgcgg gtgagacccg gctcgcggcg gcgcagcgcg
      781 atcacggaga tgttgacgac ggccatgatg gcgagcgtgc cgatggtgca caggttcatg
      841 acggcgtcga gggaggcgaa ggccgccggg accgcgaaga cgacggcgac gatcagcgtg
      901 ccggcgacag gcgtggacgt cctcggcgac accttctcga agacggccgg gacgagaccg
      961 tcccgggaca tcgacatcag gatgcgggtc tggccgtaca tcacggcgag gacgacggag
     1021 gcgatggcga cgaccgcgcc gaaggcgatg acaccgccgc cgacggcgga gccggtgacc
     1081 tcgttgacga cgtaggagag ggccgcgggc cggccggcga cctggtcgcc gccgacagcg
     1141 ccgatcgcgg cgaccgcgac ggcgcagtag agcagggtga ccaggcccat gcagacgagg
     1201 atcgcgacgg gcacgtcccg gcgcgggttc ttcgcctcct cgccggcggt ggtgatcgcg
     1261 tcgaagccga tgtaggagaa gaacgcggcg gtggtgcccg cgccgatgcc gccgagaccc
     1321 gccggggaga acggggtgag gttgccgtcc ttgaaggcgc tgtagccgat cgcgcagaag
     1381 gccagcagga tggcgagctt gaccgcggcc atggcggcgg tggcccgggc gctctcgcgc
     1441 accccgcgca cgagcagcac ggaggccatg ccgatgacga tcaccgcggg gaggttcacg
     1501 gccccgccgt cgcccggccc cgccgacagg gccgccggga gctgccagcc ggtgaggctg
     1561 tgcagcagtt cgttgacgta ctggctccag ccgaccgcga cggccgagat ggagatgccg
     1621 tactccagca gcaggcacca gccgaccagg aacgcggtgg actcgccgag gtcggcgtag
     1681 gcgaaggagt acgaggagcc ggagaccggt atggcgccac ccagctccgc gaaggagaag
     1741 gcggtgaata cgcaggtcag cgcggcgagg atgaaggaga cgacgacggc ggggccggcc
     1801 tgggcgacgg agtcggagag gccgacgaag atgccggtgc cgacgatggc gccgacgccg
     1861 aagcagatga gctggaagag gcccatggtg cgcttcaggc cgtgcccctc gcggtcggcg
     1921 ccggattcgg cgacgagcag gtgcggggac ttgatgcggg gagcgggcat gcgggtggtg
     1981 ctcgtttctg gtggtgcggg cgcccgtcgt acgggcgcgg cgacggcccc ggaatgggtg
     2041 gctccgggcc gccggtcagg ataagacggg tcaggcgagc gtggctacca gtaccgcctt
     2101 gatcgtgtgc aggcggttct cggcctcgtc gaagacgacc gagtgcgcgg actcgaacac
     2161 ctcgtcggtc acctccaggg cggtcaggcc gtgtctttcg tggatctccc ggccgacctc
     2221 ggtgccgagg tcgtggaagg ccggcaggca gtgcaggaac ctgacgtcgg ggttgccggt
     2281 ggcgcgcagg acgtccatgg tgacggcgta gggggcgagg gccgtgatcc gctcgctcca
     2341 cacctccttg ggctccccca tggagaccca gacgtcggtg gcgacgaagt cggcgcccgc
     2401 gacgccgtcg gcgatctcct cggtgagggt gatgcgggca ccgctggacg cggccaggtc
     2461 atgggcgcgg tcgatgatct cctgggcggg ccagtaggac ttcggggcga cgatccggac
     2521 atccatgccg agcagggcac cggtgaccag gtaggagttg cccatgttga agcgggcgtc
     2581 gccgaggtag gcgaaggcga tcttccgcag cggcttggcg ctgtgctcgg tcatggtgag
     2641 cacgtcggcg agcatctggg tggggtgcca gtcgtcggtg agaccgttgt agacgggcac
     2701 gccggcgtgc gcggccagct cctcgacctt ggcctggctg tcgccgcggt agtcgatccc
     2761 gtcgtacatc cggccgagga cccgggcggt gtcccgcacc gactccttgt gcccgatctg
     2821 cgagccggag ggttcgaggc aggtggtgtg ggcgccctgg tcggcggcgg cgacctcgaa
     2881 cgcgcagcgg gtgcgcgtcg aggtcttctc gaagatcagc gcgatgttcc tgccccgcag
     2941 gtgctgggtc tcggtcccgg ccctcttggc ggccttcagc tcggcggcca gctcgaccag
     3001 gccgcggaac tcctcctcgg tgaagtccag ctccttgagg aagtggcggc cggcgagggc
     3061 cgtcggcact gtcgccatgg ggggcgctcc agacgtacga ctacggatga ccctgaaagt
     3121 ctatacgatc ctccacattt ctatacggcg tctcgctcca cgggacagct catgcaccgc
     3181 gggccgcccc ggccccgtcc cagctcgctg cccgggatct cgatcacctc gatgccgcac
     3241 ttgcgcagat gggtgttggt ggtcacgttc cgctcgtagg cgaccacgac accgggttcc
     3301 acggcgagga cgttgcagcc gtcgtcccac tgctcgcgtt cggcggcgtg cacgtcctgg
     3361 gtggcggtca gcacccggat ctcgccgagg ccgagcgcgg cggcgatcgc gcggtgcatg
     3421 tgctccgggg gatggtcggt gaccttcagc tcccgttcgc cgacgcccgg ttcgatggtg
     3481 tacgagcgga gcatgccgag gccggcgtac tgggtgaaga tgtcgccgtc gaccatggtc
     3541 atcaccgtgt cgaggtgcat gaaggcacgc cgcttgggca ggtcgagggc gacgatcgtg
     3601 cgcgccgagc cggccgcgaa cagcttgtgc gcgagcatct cgacggcctg cggggtggtg
     3661 cgctcgctca tgccgatcag gacgacgccg ccgccgagca ccaggacgtc gccgccctcg
     3721 atggtggagg ggtagtcggc ctgtccccgg gaccagacgt gaaacgtttc gccgtggaac
     3781 agcggatggt gccggtagat cgcctcgaag tgcacggtct cgcgctgccg ggcgggccgg
     3841 cgcatggcgt tgatggagac gccgtcgtag atccacgcgg aggtgtcgcg ggtgaacagg
     3901 tggttcggca gcgggggcag caggaagtcg tccagatcca tgacgtggaa gcggaccgag
     3961 gtcggttccg cgtgcgcgtc caggaactcc cgcttggtca tgccgccgac cagcgcctcg
     4021 gccagctcgg gcggggccat cccgtcgaag gcggcccgca ggtggtcggt ggcgagcggg
     4081 ccgtactcct tctcgtcgaa gacgcggtcc aggacgagcg cgcgggcctc ggggagcgcc
     4141 agggtctcgg cgagcaggtc cccgaagagg tggacctcga ccccgcggtc gcgcaggacg
     4201 tccgcgaacc cgtcgtgctc ggcgcgcgcc cggcgcaccc agagcacgtc gtcgaagagc
     4261 agggcgtcct tgttgctggg ggtgagcctc ttgagctcaa gatccggccg gtgcaggatg
     4321 acgcggcgca gccgcccggc ctcggagtcg acgtggaatc ccatgcatcc atcctgacca
     4381 ccgaggccgg ggttcacccc ctgcccggcc ggatccgctt cccccttctt cgtcacaccg
     4441 gtcaggaggg gtcccggggc ggaatcagat cgcggtgcac ggaaccggcc accgcccgat
     4501 ccgcggcggc aggctcaccg cccacccgcc ggcggacagc accagccgtt cggtgacgag
     4561 ggggccgagc gcctcgtgtc cggcggcgtc cagggcgtcg acgggcgtcg gctccaggag
     4621 gcggaggaac gtggcgacga gagcggggtg gtccagggtg agccgcacgg ccgtgccccg
     4681 ctcccggcgg tccaggacgg tgacgaagtc cgggccgcgc cggtggtaga ggacgccgtg
     4741 accgtaggcc ggccgccagt ccgccggccc gcccgcgggc gcggggggcg aggtgggtgg
     4801 tgggaggtgg tacaggaggg cggggtcgta cgccggggtg cccgtcgccc gccagtccac
     4861 gcgcaggccg aggctctggc actcgcgcag gaaccgcaca gcctccgccg tcccgcgccc
     4921 gctcccgctc aggtccaggg gcccggccgt ctccacccgg cgcccggtga gccggtgcgg
     4981 cacggtgccg ggcagcccgc tcatccggcc ccctcgggca gccgtaccgg ttcgccccag
     5041 gtcggcaggg ccacgtaggt ggcgccgtcc cggaacagca ggccgagccg caggacctcg
     5101 tcgacccagt ccgccagcgc gccggacggc acctcgtggc cgtcggcggc cagcagccgg
     5161 tgcagcgcgg gaacggtccg gccgtcctcc aggcggcgca gggccgcggc tcgccagccc
     5221 gtgaagcggt ggccggcggg cggccggccg tgccgtcggt cgtgcaccag caggtcagga
     5281 ccgtcctcct cgaacagcag ccgggagtgg gcgtgcccgg cccgccaggc ggccacggcc
     5341 gcccgcaacc gccgttcggc cgggccggtg atgcccgcgt catcggcgtc gaagaggtag
     5401 accaggtcgg cgagttcctc ctcgggcagg tcgaagacgt gctggtacat ctcggccggg
     5461 cggcgcttgc cgaaaccgag tcgcggatcg gtgaagtggg ggctgaaccg ctccagttgg
     5521 atgcggtggg cgccgctggg cggctggagg tggaccaggg ccgggagctg gtcgatgacg
     5581 ggcgtgtagt cgtcggcgct ctcgccgggg aagccgtaca gcaggttcca ggagcaggtc
     5641 agcgcgtggt tctcgcactc gcgcagggtg cggacgttac gggcgccggt gacgcccttg
     5701 tccatgaggt ccagcacgcg gctgccgagg ctctcgatgc cgggctggat gtgcaccgtg
     5761 ccggacgcgg cgaggagccg tagctggtcg ggggtgaggt tggacttgac ctcgtaatgc
     5821 agccgcaggt cccagccgct gccggcgacg cggggcagga agtcgcggaa ataggccatg
     5881 tcgatgatgt tgtcgacggt gaccacgtcg agaaggcggt ggcggcgcac cagccggtcg
     5941 atctcggccc acagccgctc ccccggcttg gcccggaact ccatggcggt gccgttcagc
     6001 ccgcagaagg tgcagtggtg cctctcgccc caccagcagc cccgggcgcc ctccacgacc
     6061 agcttggggt ggacgtgctc ccggaccggg gaggcgtcca gcgcggcctg ccactggtcg
     6121 tagtccggcg aggggatgtc ggcgggggcc acggtccgcc gggtctcggg gttggcccgc
     6181 gccgtggtgc cgtcccacca gcacaggccg ggcacgtcgg ccggggcggt gccctcggcc
     6241 aggtgccgta agagggccgg taaggcgtac tcggcctcgc cgcggaccac gtggtcgacg
     6301 aagcggtggt tgcggtgcag ggcgtggccc atgggcccgt cgcagttgct gccgccgagg
     6361 acgaccgcca actgcggtct tcggcgcttg agttcgcggg ccagtgccag ggagggcacg
     6421 ttctgcatga acgtgctggt gaacccgacc acgtccggct cggccgccag cacctcggtg
     6481 gcgcaggcat cgacgaaggg ggcggcgtgg gggcgcatgg cgacggccgt gtcgatgcgg
     6541 acgtcccggc cggccgcgta gtcccgcagc cgggccaggc cccagccggg gtcgtcgtgg
     6601 aggactccgg agaagaccca gtcgccgagg ccgtggaaga tcccgtcgct gccgacctcc
     6661 acacagtcgc ccggcagcag ccggccgccg gtccgctcca gcaggaactc cgcccagcgc
     6721 agcgagccgt ggaactcggt cacctcgtcg ccgggacgcg cctggcgcac gatccggttg
     6781 agaaggccca gttgcagcga gggcaggtcg agtggatgcc acggcatggt gaccaggtgg
     6841 acgcgcatgc tcagcgggtc ggccgcttct ccaggatcgc cggccggcgc gtggtgctcc
     6901 tcgggtcctc gcggaccacc accttcttga tctccacgcc caccactccc ctcacgacgc
     6961 gccaacgccc ccgcgacgca tggctgtcca ccatatggac aggtgtgtgt gcggcacaag
     7021 ggcgctccgg gccggcccgc ctacaggcgc gggtccaccg gctccgactc cagcgccagc
     7081 accccgaaca ccgcctcgtg cacccgccac agcggctccc cttccgcgag ccggtccagg
     7141 gcctccaggc cgagcgcgta ctcgcgcagg gccagggacc gcttgtgggt caggaaccgc
     7201 cgccgcagcc gggcgagatt gtccggccgg gtgtactcgg gaccgtagat gatccgcagg
     7261 tactccctgc cccggacctt caggccgggc tgcaccagcc gtccgtcccc gccccggacc
     7321 agcgcgccga ccggtttgac gaccatgccc tcgccgcccc ggccggtcat ctccagccac
     7381 cagtcgacgc ccgcgcggac cgactccggg tcaccggtgt cgacgtacag ccgccgggtg
     7441 gtcccgagca gtccgctgcc gtcgtgctcc accatccggt cgatcagggc cagttgtccg
     7501 tcgtgcggca gcgcggcgag gctgcggccc tgggcggcca ggatctggaa gggggccagc
     7561 cggacccctt ccaggccctc ggtggtccag cagtagcggc ggtaggcggc ggtgaacgcg
     7621 gcggcgtcac cggcccgttc ccgctgccgg gccagcaggc cgccgacgtc ggcgccgcgg
     7681 gcggctgccg cctccagggc ggcgagcgcg tccgggaaca ccgcgccgga ggccgcgccc
     7741 accgccgcgt actggctgcg cagcagcccg gcggccttca gcgaccaggg catgagttcg
     7801 gcgtccacca gcagccagtc cgtggcgagt tcgtcccaca gcccggcgtc cgtgaccgcc
     7861 gagcgcagcc ggccgaggat ctcctccgtc gtctggccgt cgtcgaagaa cggccgcccg
     7921 gtacgggtgt acagcgcgcc cgtcgggcct cccgcgactc cgaagcgggt gcgggcgacg
     7981 tccgcgtccc ggcacaccag ggccacggcc cgcgagccca tgtgcttctc ctcgcacacc
     8041 aaccgcgcga ccccgtcccg cgcgtactgc gcgaacgcct cctcggggtg ctccaggtag
     8101 ccgtccaccg ccgaggtggc cgtcggcgcc atggtcggcg gcaggtaggg cagcaggcgc
     8161 gggtcgaccg cgaagcggct catgacctcc agggccgccg ccgcgttctc ctcgcgcacc
     8221 gccaccctgc cggcgtgccg ggtctgcacg gcccggcggc cgtgcacgtc cgccaggtcc
     8281 agcggccggc cgtcgtgccc gccgggcgcc tcggagcgca gcggcttcgc cggctcgtac
     8341 cagccccgct gcgccggtac gtcgaccagc tcgcgttccg gccagcgcag cgcggtcagc
     8401 ttgccgccga agacggcgcc ggtgtccagg cagatggtgt tgttgagcca ggtggcctcc
     8461 gggacgggag tgtgcccgta gaccaccgcc gcccggcccc ggtagtcctc cgcccacgga
     8521 tagcgcaccg gcagtccgaa ctcgtcggtc tcccccgtgg tgtcgccgta cagggcgtgc
     8581 gagcggaccc ggcccgaggt gcggccgtgg tacttctccg gcagaccggc gtggcagacc
     8641 accagccggc cgccgtccag gacgtagtgg ctgaccagcc cgtccaggaa ccggcggacc
     8701 tcggcccgga actcctcgct ctcccccgcc atctgcgcga cggtctcggc gagcccgtgg
     8761 gtgtgccgga ccgtgcggcc cttgaggtga cggccgtact tgttctcgtg gttgcccggc
     8821 acgcacagcg cgtcacccga cttcaccatg cccatcaccc ggcgcagcac cccgggggtg
     8881 tcggggccgc ggtcgaccag gtcaccgacg aagacggcgg tacggccctc ggggtgcacg
     8941 ccgtcggcgt accccagctc ggcgaggagc gactccagtt cggccgagca gccgtggacg
     9001 tcgccgatga tgtcgaaggg gccggtgaga tgggtcaggt cgttgaagcg cttctcggtg
     9061 acgacggtgg cgttctcggc ctcctccacg ccgcgcagca cgtgcacctt gcggaagccc
     9121 tcgcgctcca ggtggcgcag ggagcggcgc agttcgcgga tgtggcgctg gatgacccgg
     9181 cggggcatgt cggcgcggtc cgtgcgggcg gcgttgcgct cggcacacac ctcttccggc
     9241 atgtccagca cgatggcgat gggcagcacg tcgtgcttct tcgccagttc gatcaactgt
     9301 cgccggctgt cctgctgcac gctggtggcg tccacgacgg tgcgacggcc ggcggccagc
     9361 cgcttgccgg cgatgtagtg caggaggtcg aaggcgtccc cggaggcgct ctggtcgttc
     9421 tcgtcgtcgc agaccaggcc gcggcagaag tcggaggaga gcacctcggt cggcttgaag
     9481 tgccggcggg cgaaggtcga cttgcccgat cccgaggcgc cgacgaggac gaccagggag
     9541 aggtcggtga cgggcagcac ccgtcccgtg cgggtcccgg tcatgcggcc ttcgcctcct
     9601 tcttctcgtc cgtggcggtc gtgcgggtga acacggccat ctgggtgggc ggtccgaccg
     9661 cggggtcgcc cggcccgacg ggggtgaacg cgacgtcgta gccgtgccgt ccggccacgg
     9721 cttccgccca ggcacggaac tcctcgcggg tccactcgaa acggtggtcg ccgtgccgga
     9781 cgcgtccggc gggcagggtc tcccagcgca cgttgtactc gacgttcggg gtggtgacga
     9841 cgaccgtgcc ggggcgcgcg tgcccgaaca cggcgtactc cagggcgggc agccggggca
     9901 ggtcgagatg ctcgatcacc tcgctgagca cggcggcgtc gtaccccttc aaccggttgt
     9961 cggtgtaggc cagcgagccc tggacgagcc tgacacggga cgcctgccgc tcccccatgc
    10021 ggtcgagccc gagccggcgg gcggcgatgc tcagggcccg cacggacacg tcgacgccga
    10081 ccacctcggt gaaccgcgcg tccttcagca gctcctgcac caactgaccc tgcccgcagc
    10141 cgaggtccag cacgcgggcg gcgccccgtt cgcgcagggc ggcgaggatc gcctcccggc
    10201 gccggacggc gagcggggcc ggtttctcct cggcctccgc gccggtgtcc tgcgcgaccg
    10261 cgttgtcgat gtcctcgacc tcgctgtcgt cggcctcggc caggcgcacc agctccagcc
    10321 gctcccgcgc ctgccgggtc agcgaccagc ggcgggagag atagcggctg gtgatcagct
    10381 cctgctccgg gtgcccggcc agccagccct cgccggcccg cagcagcttg tccacctcgt
    10441 cggcggagac ccagtagtgc ttggcgtcgt cgaggaccgg cagcaggacg tacaggtggc
    10501 gcagcgcctc ggcgagggtc agtgtccgcg actccaggac gaggcggacg taccgcgagt
    10561 cgccccactc cgggaacgtg gtgtcgaggg gcacggggtc ggcggtcacg ctccagccga
    10621 ggggctcgaa gaggcgtcgt accaggccgg cgccgccgcg ggccgggagg gccggtatcc
    10681 cgacgcgcag cggcagcggc gtggtcgccc gctccggacg ggcggcgcac accccgcgca
    10741 gggcgctgga gaacacgttg ctcaacgcga ccgcgagcag cgaggaggcc gcgtagggac
    10801 ggtcgttgac gtactgggcg agggccgcgt cgggtgcgcc gccgcggccc ttgcccttcc
    10861 ctcgcctgac cagcgcgacg gtgtcgatct ccagcaggag cgcggccgtg cagcgctcgg
    10921 cgtccgcctc ggggtagaac acgtgcgccg tgccgtacga ggtggagaac gcctgcgcct
    10981 tgtcggggtg cttgtgcagc aggtacccca ggtcggtggc cgggctgccg ggcgcaccgg
    11041 tggtggagat cgtcacgagc atggtgccga gtctcccggt ccccggcccc tgtgaccaga
    11101 ggttttccgc atcccggtgg tcggccgtgg cgccgggacc ggccgcctgg acctgcggtg
    11161 gggcgctgtc gtcgccggtc tcaccgccgc ccgcgaaggc gccctgccgt gccgtgtgat
    11221 ctccgttatg gcccccggca cccggacctg gtgaagtgag tgctcgtcaa ctgaccagtg
    11281 acagaagggg gaaccatgac catcggccag ggagtccggg tacgcgggag agccgccgcc
    11341 gtcgtggcgg ccggcgccgt cctgggtgcg ggggtcctcg cgaccgctcc ggctcgcgcg
    11401 ctcacgccga cgcccgccgc gagggtggtg cccgccgccg cggcggcgcc gcaggtgcag
    11461 gcccagggcg cgtacgcgat ggacgcggcc accggcaagc agctcttcgg caaggcgccg
    11521 aacggacagc tccggaccgg ctccaccacg aagatcatga cggcgctcgt ggtgctgtcc
    11581 cagcggaacg ttgacctcga ccgcaaggtg aggatcagga aggagtacac ggactacgtc
    11641 atcgacccgg tcacgcacac ccagcgctac tccagcgcga acctgatcct cggcgactcg
    11701 atgaaggtgc gcgacctgct gtacgggctg ctgctgccct cgggctgcga cgcggcgtac
    11761 gcgctcgccg acacgtacgg gtcgggcacg acgacggccc agcgcaccaa gtcgttcatc
    11821 ggcaagatga acgccaaggc ccgcgaac
//
