LOCUS       NZ_RAII01000001        22360 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6964004
            Orig. end                         :: 6986364
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22360
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="28"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..22360
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22360
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[<10000:12360](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <10001..12360
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(143..160)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    complement(166..180)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    278..292
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.23"
                     /tool="antismash"
     misc_feature    complement(339..352)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     misc_feature    1036..1049
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            <1352..2071
                     /locus_tag="EBH12_RS33325"
                     /pseudo=""
     CDS             <1352..2071
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033580.1"
                     /locus_tag="EBH12_RS33325"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HRQMIDAVRYLVDNGIKWRAMPSDFPPWPRVYAFFARWRDAGLVT
                     ELHDRLREAVRRAEGRSPEPSAAVVDSQSVKADATVTLTSRGYDAGKKINGRKRHLLTD
                     TLGLLLDVLVTPASTTDRDAARIVLAAAKKHFRRLARVWADGGYTGHLTDWTDQHLGVV
                     LDIVRRSDDTRGFQVLPRRWVVERSFAWLLRSRRLVRDYERRPDTSESVVLWSMTMLMS
                     RRLAARRRQSPAPARAA"
     gene            complement(2010..2513)
                     /locus_tag="EBH12_RS33330"
     CDS             complement(2010..2513)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828145.1"
                     /locus_tag="EBH12_RS33330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_114875235.1"
                     /transl_table=11
                     /translation="MRAVLEARQKAAAVRVEDLEAELERVRAALTEAEEMLRRRVIGLE
                     QYLEALAEEDAPAVAVVSQRKPVGPRRAVPHRQDAAGPEVLSVDYQALMAAALEAGVDG
                     LGARRAAVVLGWDSASASRVEGARARLKRLVERGWLVEEKPGRFMLPAPELETAGAGRP
                     GGGS"
     gene            2767..4503
                     /locus_tag="EBH12_RS33335"
     CDS             2767..4503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535848.1"
                     /locus_tag="EBH12_RS33335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_196421377.1"
                     /transl_table=11
                     /translation="MAAANTLVENRSGVRSKEATSIADTLLRAPVPVRRAALKTLDAVD
                     LTHVLAEVERETGSLYGLWADTPSGFIEDVLGESIWSKQREIVDAVPKHTRVMVPAGFG
                     VGKTYIAGRLCAWAGATNPVGTMLVVTTATRFRQVRNQLWPHIRKTISRAGLPGFCDEV
                     QWKMPDQWNNDVRVAYGFTAQAHDEASMQGIHGNPKLVIIVDEAGGIARSIGAGTNNLL
                     TGDARMLAIGNPPTDDPRSWFEVMCEEGDDPDEPGTVTIPIATLDSPAITGERVPYCLD
                     CPSAVARHSLAIHLPAQDWVDRTIREYGDDHPYVIAKVHAKFPKGGGGKVIPTTWVEDA
                     KDNEDPTGPGWVRLCDLGLDGEKATHTVKRGAWVRLGVDVAADGGDEFTIYRIVGDVVE
                     HRHHSSGMANDNQVKVAKKILEEVKAAERLAKALGSTAKVHVKIDKNGLGHGAVGMLEV
                     WGQNGRHHSEVFGVMVSESPDRDDPGAPMRPYRKRDEMWLATRQLLQPDPATGTGRLRL
                     RVDREAAIQLTTPNLGNNAGGYAVVESKKQMQARGMKSPDRAEAILLAIYEPNPRRRGI
                     IA"
     gene            complement(4753..4908)
                     /locus_tag="EBH12_RS35455"
     CDS             complement(4753..4908)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EBH12_RS35455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_155553701.1"
                     /transl_table=11
                     /translation="MPDQAVGVVDGRTVPVVADDPEGGPVGVDVVVVGVERAGEQLGDL
                     DVGGAG"
     misc_feature    5418..5432
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.7"
                     /tool="antismash"
     misc_feature    complement(5442..5457)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.68"
                     /tool="antismash"
     gene            5497..6090
                     /locus_tag="EBH12_RS33340"
     CDS             5497..6090
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982791.1"
                     /locus_tag="EBH12_RS33340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_241563501.1"
                     /transl_table=11
                     /translation="MTDYTALVAAAAHAAGPAPTSPSGEAGWLTRVQHLATELAFTARQ
                     VEQAVQTLDASRPFAAFLERVEIEESSRRGLLTLRPDSGVAETIRTEQDTTLSGRAMIE
                     RARELEGRWVLVYRYNQPKSGGKFENVRMVARLLDLGEGTLANQVARQVLIGDAGGDEQ
                     RAAAAWKEAGLPLSGSIPVADLEPVRRTLRGEQL"
     gene            complement(6274..6876)
                     /locus_tag="EBH12_RS33345"
     CDS             complement(6274..6876)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057321.1"
                     /locus_tag="EBH12_RS33345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_114874413.1"
                     /transl_table=11
                     /translation="MIGRLPLDEQLGFFIGTLSRNETLLEVLDRTTAMNPPSWYLTAGC
                     LFQTVWNVVTGIPPAEGIKDYDVFYFDDRDLSWEAEDQVIRAAAATFADLPAEVEIRNE
                     ARVHLWYEQKFGVPCAPYTSTEAAIDSFAATTCCLGVRLEPDGRWRVYAPHGLSDVFGL
                     VVRPNPVLAPRAVYEAKTERWRQQWPELTVLEWPVAT"
     misc_feature    6861..6870
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(7012..7027)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(7750..7765)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    complement(7761..7774)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            complement(8024..8638)
                     /locus_tag="EBH12_RS33360"
     CDS             complement(8024..8638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028922.1"
                     /locus_tag="EBH12_RS33360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_114874414.1"
                     /transl_table=11
                     /translation="MRVNKLTIAALAVVAGLSLTACQNEDVAADPKPATSAPAANGDAG
                     QEQGQQDGTVAGVETNEDGKTATCRTDELDVTATDATIDGDTDGTVAVTFTNGGGRDCA
                     LSGYAGVDLKTSAGSLSAERTGEESPSVVLKDGEKVSFAVVYPVNDSGGSGVRVTGLVV
                     TPPDETKSVTLDWPGAGSLPVTDGSGTPVQVGPIGSAGQGG"
     gene            <10001..11218
                     /locus_tag="EBH12_RS33370"
                     /pseudo=""
     CDS             <10001..11218
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="EBH12_RS33370"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /pseudo=""
                     /sec_met_domain="YcaO (E-value: 2.1e-48, bitscore: 164.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SLGTTFGDPEQARVAAIAEGMERYCGNRVPPPGHPDAPLRATAAE
                     LADKGLRLYGPADLPAYAPWQYARAKFPYRPLTADTPALWTRGTERLPDGPPAEVWAPV
                     SLTHLNWRQGGLRELPRTHHLNYAGIATGQGLDDAVERGLLEIVERDALELWWHLDGPA
                     RGIDPASVPGLSDDLAGSALDVHIVEMHSEFAPCMAALVHDPRLGLYAAGFACKYDPAE
                     AARKAVLEAVHTWVFTQGLTGPDGWVFQAVEAGLLARGLYLDHRADGRYLDVCGEQFEH
                     VRDLGAHVQVWLDERMAVEARRFTEPALGTVSVAEVEPGSRERLESTLREGGHRVMTFD
                     LTTEDVAETALRVARVLVSGLLPNAPAAFGYFGCPRLAEAAVARGWRATAPSAPEDFTL
                     APPPHM"
     gene            11227..12360
                     /locus_tag="EBH12_RS33375"
     CDS             11227..12360
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048308.1"
                     /locus_tag="EBH12_RS33375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_241563696.1"
                     /sec_met_domain="PF00881 (E-value: 0.00019, bitscore: 20.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDHREDPQTGLVAALARARSPERPGPDTPAGAPVRAWAGPPLPI
                     PQAGPAHLDLRTLLRLSLAASDTSGRLRPTPSAGALHPVDTELVVGTGCSLPPGRYGYD
                     PLRHRVHHVGPPVDSTPPGVTAALSVTAQRTVSHYGHRAWPLLLLDTGHAAAALFLAAR
                     VLGAGESDVRMDGRTENPLAVVRIRPPYGRSPRHSAGTEDPPAPADLLARRSTPPPLVG
                     LPPRDALRAVLSTAERAGGGDLLRWCAAVGPPRPGLMQLGPKGTTLRRYASGEARPTLA
                     AWAAGQAWLADAGAVLLAHGCPADADATHIRRAHLRAGFAVHLAHVTALRHGLAARPVG
                     SWQQADLGAALGAPPGRDWVVHALALGTHHADEESST"
     gene            12357..13943
                     /locus_tag="EBH12_RS33380"
     CDS             12357..13943
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="EBH12_RS33380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_121740644.1"
                     /transl_table=11
                     /translation="MIVHPELRRAARHARRPLLAATLLQGAVTLTYLAQAVLLALALAG
                     LARGDTGRLPWLLAGVLAVVAARAELALWQRRTATRAGARVRVALRDELLAHLGRLGPA
                     YLTTARAGAVRTTLVDGVEGVDAYVSRYLPQLLVTLAVPPLVLAVLVVVEPRALLGLVP
                     ALLLALLGPRAWDRLLAARGKEHWDTYEGLGADYLEALQGMPALRAAGAVGRTRARLEE
                     RSAALHRATVAKLRVSLADTGITDLAIQGGTAAAALLACWSAVTGSTTAAGTYLVLLLA
                     SECFRPVRDHAREWHAGYLGVSAADGLASLRTSVPAVPDTATAPAHWHTPPELSFHNVR
                     FTYDGADAPALDEVSFTARAGRTTAIVGPSGAGKSTLLALLLRHHDPQEGRITLDGRPT
                     TEYALDSLRQGIAVVSQETYLFHATIAENLRLARPDATDDELTRAARAAGIHDEIAALP
                     DGYATLLGERGATLSGGQRQRLALARALLSDAPVLVLDEATSSVDERREADIVRELLNA
                     VGGLSFGSGRL"
     gene            14212..15588
                     /locus_tag="EBH12_RS33385"
     CDS             14212..15588
                     /NRPS_PKS="Domain: Aminotran_5 (41-427). E-value: 1e-78.
                     Score: 256.8. Matches aSDomain:
                     nrpspksdomains_EBH12_RS33385_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522005.1"
                     /locus_tag="EBH12_RS33385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_114873549.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-75, bitscore:
                     252.5, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.7e-07, bitscore:
                     27.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAAATATAVAAEPSVCAPLPVLGRDVAVPLVTGGEVTYAALDQA
                     ASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFENARRTVAEFLDCRDGDEVVF
                     TRSTTDSLNLLAAALPDGCEVFVFETEHHAALLPWLRAGRVTFLDAPDSPAQAVAALER
                     ALADRDPYGPALVCVTGASNVTGELWPVRELAAAAHAHGARIVLDAAQLAPHRAVSVRE
                     LDVDWVAFSGHKLYAPFGSGVLAGRADWLREAEPYLAGGGASRTVVRRADGGVDVRWHE
                     TAARHEAGSPNVIGAYAVASACKALTEAGFEALAAREDALVRAVREGLADVPEVRFLSL
                     FGDDAPRVGVLSFVVDGWNSSHFAAALSAEYGIGVRDGLFCAHPLVRRLLGGDTGGAGE
                     CGAPEPGALNAIRVSFGAGTPEEHVARFVRAVRELVRDGARWTYRTVDGRCVPDAWGRA
                     "
     aSDomain        14335..15492
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS33385_Aminotran_5.1"
                     /evalue="1.00E-78"
                     /label="EBH12_RS33385_Aminotran_5.1"
                     /locus_tag="EBH12_RS33385"
                     /protein_end="427"
                     /protein_start="41"
                     /score="256.8"
                     /tool="antismash"
                     /translation="LDQAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFENA
                     RRTVAEFLDCRDGDEVVFTRSTTDSLNLLAAALPDGCEVFVFETEHHAALLPWLRAGRV
                     TFLDAPDSPAQAVAALERALADRDPYGPALVCVTGASNVTGELWPVRELAAAAHAHGAR
                     IVLDAAQLAPHRAVSVRELDVDWVAFSGHKLYAPFGSGVLAGRADWLREAEPYLAGGGA
                     SRTVVRRADGGVDVRWHETAARHEAGSPNVIGAYAVASACKALTEAGFEALAAREDALV
                     RAVREGLADVPEVRFLSLFGDDAPRVGVLSFVVDGWNSSHFAAALSAEYGIGVRDGLFC
                     AHPLVRRLLGGDTGGAGECGAPEPGALNAIRVSFGAGTPEEHVARF"
     gene            complement(15730..16011)
                     /locus_tag="EBH12_RS33390"
     CDS             complement(15730..16011)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007828132.1"
                     /locus_tag="EBH12_RS33390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC ligand binding domain-containing
                     protein"
                     /protein_id="WP_006136621.1"
                     /transl_table=11
                     /translation="MITAIVLIKTSVDRIPEIAEQIAALDSVSEVFSVTGTYDLIAMVR
                     VREHEDLAEVIPGRISKIPGVEGTDTHVAFRTYSQHDLEAAFAIGLDS"
     gene            complement(16008..16709)
                     /locus_tag="EBH12_RS33395"
     CDS             complement(16008..16709)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129991.1"
                     /locus_tag="EBH12_RS33395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="WP_121740748.1"
                     /transl_table=11
                     /translation="MRTTPAPVTRTLIVLCCLVFLIGPASGLHPAHGSGEELLAAQRDY
                     FRRWGVIPADLFDGSPAAVLTPATALFVHGSWVHLLGNMLFLHVFGPLTEARMGRVRFA
                     LCYAGCGYLALLGYAAANAGSERSLVGASGAISALLGAFLFLFPRGRVTSLLPFAFFLP
                     VRLPAWAVLPFWAALQWAAAGRTPEGGPGVAYLAHLLGFALGFGCAWVWRGGATTVKPA
                     PAPAPEGENQP"
     gene            <16749..17451
                     /locus_tag="EBH12_RS33400"
                     /pseudo=""
     CDS             <16749..17451
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020140773.1"
                     /locus_tag="EBH12_RS33400"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="precorrin-3B C(17)-methyltransferase"
                     /pseudo=""
                     /sec_met_domain="TP_methylase (E-value: 7.7e-21, bitscore:
                     73.7, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GRLAVVGLGPGARDLLTPRARDELRRASVLVGLDQYVDQIRDLLR
                     PGTRVLESGLGAEEERARTAVEEARRGQAVALIGSGDAGVYAMASPALAEASDDIDVIG
                     VPGVTAAPPAGAVLRARPGHAVGGHRAAGAGGGRGGPGGDVLQPAQPGP"
     gene            17448..18035
                     /locus_tag="EBH12_RS33405"
     CDS             17448..18035
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132691.1"
                     /locus_tag="EBH12_RS33405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_114873418.1"
                     /transl_table=11
                     /translation="MNRVIHPIEQESFRRLRARLDTSGLPPLTRAVVERVVHSSADLEY
                     ATDLVVDEAELERAHTALHAGAPVVADVEMVAAGITRRETVCRLREARSGPGLTRSAHA
                     VRLAYEEVGPGAVWVIGCAPTALEELLTLDTSPALVIGLPVGFVGAAESKAALRESGLP
                     AVSNVSEKGGSAVAAAALNALLYHPASTEETL"
     gene            18032..18943
                     /locus_tag="EBH12_RS33410"
     CDS             18032..18943
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976961.1"
                     /locus_tag="EBH12_RS33410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sirohydrochlorin chelatase"
                     /protein_id="WP_114873419.1"
                     /transl_table=11
                     /translation="MTTPPALLIAGHGTRDDAGAEAFRAFVRELGRRRPDLPVAGGFIE
                     LSPPPLGEAVAELVERGVRRFAAVPLMLVSAGHAKGDIPAALAREKERHPGVSYTYGRP
                     LGPHPGLLRVLERRLAEAVDPSWDPAEVTVLLVGRGSTDPDANAEVFKAARLLWEGRGY
                     AGVETAFVSLAKPDVPGGLDRCARLGARRIVVLPYFLFTGILPDRVRTQTEEWAAARPE
                     AEVRSADVIGPEPELLDLVLERYEEAVKGDLRMNCDSCVYRIALPGFEDKVGLPQQPHF
                     HPDDDGHHHHGHGHSHSHSHAH"
     gene            18933..19994
                     /gene="cobC"
                     /locus_tag="EBH12_RS33415"
     CDS             18933..19994
                     /EC_number="4.1.1.81"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (26-346). E-value: 2e-36.
                     Score: 117.8. Matches aSDomain:
                     nrpspksdomains_EBH12_RS33415_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="cobC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132694.1"
                     /locus_tag="EBH12_RS33415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rv2231c family pyridoxal phosphate-dependent
                     protein CobC"
                     /protein_id="WP_114873420.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.3e-34, bitscore:
                     117.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTEPASGHDLRHHGDAEVRDGGGTLVDLAVNVRADTPPAWLRAR
                     MAASLAGLAAYPDGRAARAAVAARHGLPVERVLLTAGAAEAFVLLARALKVSRPVVVHP
                     QFTEPEAALRDAGHTVDRVLLRESDGFRLDPAAVPEEADLVVVGNPTNPTSVLHPAETL
                     TRLSRHGRTLVVDEAFMDAVPGEREALAGRTDVPGLVVLRSLTKTWGLAGLRIGYVLAA
                     PETVAQLERSQPLWPVSTPALVAAEACVSPAALAEAEEAARVVAADRAHLIAGLRDFAS
                     HGLRVTDPAEAPFVLVRVPAAADVRERLRSLGYATRRGDTFPGLDEEWLRLAVRDRKTT
                     EGFLRALGRALGA"
     aSDomain        19011..19970
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS33415_Aminotran_1_2.1"
                     /evalue="2.00E-36"
                     /label="EBH12_RS33415_Aminotran_1_2.1"
                     /locus_tag="EBH12_RS33415"
                     /protein_end="346"
                     /protein_start="26"
                     /score="117.8"
                     /tool="antismash"
                     /translation="VDLAVNVRADTPPAWLRARMAASLAGLAAYPDGRAARAAVAARHG
                     LPVERVLLTAGAAEAFVLLARALKVSRPVVVHPQFTEPEAALRDAGHTVDRVLLRESDG
                     FRLDPAAVPEEADLVVVGNPTNPTSVLHPAETLTRLSRHGRTLVVDEAFMDAVPGEREA
                     LAGRTDVPGLVVLRSLTKTWGLAGLRIGYVLAAPETVAQLERSQPLWPVSTPALVAAEA
                     CVSPAALAEAEEAARVVAADRAHLIAGLRDFASHGLRVTDPAEAPFVLVRVPAAADVRE
                     RLRSLGYATRRGDTFPGLDEEWLRLAVRDRKTTEGFLRA"
     gene            complement(<20273..21100)
                     /locus_tag="EBH12_RS33420"
                     /pseudo=""
     CDS             complement(<20273..21100)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024987.4"
                     /locus_tag="EBH12_RS33420"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF4140 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAGTAPRWDSALESVTVYAQGALCRRVARGTVPADGQVRVPGLP
                     RSLDPHSLRARVIGAPGTRATEARAEIHAEPVDEDTVAGARREVDRLTEAYQAADARRE
                     RQLKRIEEVGALRPVPPGRKREDPHRRTPVDAWLELTDFVDERLTVLHDGLRELEDELG
                     RLEHEMEVAQDRLARVSTDAPASGVASAYTAVLTLRGAPGAEAEVEIEYGVPGAVWVPA
                     YRLTHRQGEDSGRLLLRASVAQRSGEDWTGVRIAFATADLRRRTDLPRLRSVRI"
     gene            complement(<21353..21457)
                     /locus_tag="EBH12_RS33425"
                     /pseudo=""
     CDS             complement(<21353..21457)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131436.1"
                     /locus_tag="EBH12_RS33425"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="cytidine deaminase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHTHDVDEELVAAATEVARTRCRGDNHTMAAAARA"
ORIGIN
        1 tccggcatcc tgaacgtcga gatcacgccc gagctcgccg tccgcctcgc cggcgcctac
       61 gcgacgaccc tgaagaaggg ctcgaccgtc accacggccc gcgaccactc ccgaggcgcc
      121 cgagccctca agcgggcggt catctccgct ctccaggcca gcgccatcga cgtacgcgat
      181 ctggagaacg tgccgctgcc cgtggcacgg cagcagaccg cgcggggcag cgccggcggc
      241 atcatgatcc gcacgacgcc gggcgtgccc gactccgtcg acatcatgtt cttcgacggg
      301 cagggcgccg acctgtcgca gggcagccag cgcaagctgg accgtgtgtt cgcgcggcag
      361 gagtaccggc gggccttccc cggcgagatc ggtgacctgc acttcccggc gagcgtcttc
      421 gactcctaca ccgggtcgct gctgcggaac gtcgacatca ccggcatcgc cgaggccggt
      481 ctgaaggtgg tcgtcgacgc ctccaacggc agcgccggcc tggtgctgcc cagcctgctc
      541 ggcaagctgg gcgtcgactc cctgaccatc aaccccggtc tggacgagtc ccggcccacc
      601 gagacggccg acatgcggcg cgccggcctg gtgcggctcg gggagatcgt ggcgtcctcc
      661 ggtgccgcct tcggtgtccg cttcgacccc gtcggcgagc ggctgtcgct ggtcgacgag
      721 aaggggcgga tcgtcgagga cgaccgggcg ctgctcgtca tgctcgacct ggtcgcctcc
      781 gagcgtcgca gtggccgtgt cgccctgccg gtgaccacca cccgcatcgc cgagcaggtg
      841 gcggcgtacc acggcacaca agtcgagtgg acgaccacct cgcccgacga cctcacccgc
      901 gtcggcggcg aggaagggac gatcttcggc ggcgacggca agggcggctt catcgtcccc
      961 gagttcagca gcgtctacga cggcaccgca gcgttcgtcc ggctcatcgg gctggtcgcg
     1021 cgcacccagc tgacgctgag ccagatcgac gcccgcatcc cgcgggcgca cgtcctgaag
     1081 cgggacctgg ctaccccgtg ggccgtcaag ggcctggtca tgcggcgcgt cgtcgaggcg
     1141 gccggggacc gctccgtgga caccaccgac ggcgtgcgcg tggtggaggc cgacgggcgc
     1201 tgggtgatgg tgctgcccga cccggccgag gccgtcaccc acctgtgggc cgagggcccc
     1261 gacgacgcct ccgcgcaggc gctgctcgac gagtggtcgg cggtcgtgga cagcgccggc
     1321 aggtgaccct gccgcagtag acacgtactg ccaccggcag atgatcgacg cggtgcgcta
     1381 cctcgtcgac aacggcatca agtggcgggc gatgccgtcc gacttcccgc cctggccacg
     1441 ggtgtatgcc ttcttcgccc gctggcggga tgcggggctg gtgaccgagc tgcatgaccg
     1501 gctgcgcgag gccgtccgcc gggccgaggg ccgcagcccg gagccgagcg cggccgtcgt
     1561 ggactcgcag tcggtgaagg cggacgccac ggtcactctc acttcacggg gatacgacgc
     1621 ggggaagaag atcaacgggc gcaagcgcca cctgctcact gacaccctcg ggctcctgct
     1681 ggacgtgctg gtcacgccgg cctccacgac cgaccgggac gcggcccgca tcgtgctggc
     1741 ggcagcaaag aagcacttcc ggcggctggc gcgggtctgg gccgacggcg gctacaccgg
     1801 ccacctcacc gactggaccg accagcacct cggagtcgtc ctggacatcg tccgccgcag
     1861 cgacgacacc cgcggcttcc aggtgttgcc ccgccgctgg gtcgtggaac ggtccttcgc
     1921 ctggctcctg cgcagccggc gcctggtccg ggactacgag cgacgccccg acaccagcga
     1981 gagcgtcgtc ctgtggtcga tgaccatgct catgagccgc cgcctggccg cccggcgccg
     2041 gcagtctcca gctccggcgc gggcagcatg aacctgcccg gtttctcctc gaccagccag
     2101 ccccgttcca ccagccgttt cagccgggcc cgcgctccct cgacacggga ggcggaggcg
     2161 ctgtcccagc ccagcaccac cgccgcccgc cgggcaccga gcccatcgac tcccgcctcc
     2221 agggcggcgg ccatcaacgc ctggtagtcc accgacagca cctcgggtcc ggccgcgtcc
     2281 tggcggtgag gcaccgcccg gcgcggaccc accggcttcc tctgcgacac gacggccacg
     2341 gcgggtgcat cctcctcggc cagcgcctcc agatactgct ccaggccgat cacccggcgc
     2401 ctgagcatct cttccgcctc agtcagagcc gcacgcactc gctccaactc cgcttcgaga
     2461 tcctccaccc gcaccgccgc ggccttctgc cgcgcttcca acaccgcccg catcgacggc
     2521 atccgtcacc cccacgacgt ctcggtcagc aacggaccca gacttccgtg ccagccgcta
     2581 tctcatgcct gaccagcgga aaccgcacac gaggttcgga aagagaacga cctcgcccta
     2641 ctcccccccc ggggccgcgg acaccaggtg acaggcccgg gagccccttc acattccccg
     2701 ggacggtagc ggcagccgcc atgcacagtg cgcgccatgg ccgcccccag acctcaaacc
     2761 cctgctgtgg ccgccgcgaa caccctggtc gagaaccgct ccggcgtccg ctccaaggaa
     2821 gccaccagca tcgccgacac cctgctgcgc gcccccgtcc cggtgcgccg ggccgcgctc
     2881 aagaccctcg acgccgtcga cctcacgcac gtcctggccg aagtcgaacg cgagaccggc
     2941 agcctctacg gcctgtgggc cgacaccccg tccgggttca tcgaggacgt gctgggggag
     3001 tcgatctggt cgaagcagcg ggagatcgtg gacgccgtcc ccaagcacac ccgcgtcatg
     3061 gtccccgccg ggttcggcgt cgggaagacc tacatcgccg gaaggctctg cgcctgggcc
     3121 ggggcgacga accccgtcgg cacgatgctc gtcgtcacca ccgccacccg cttccggcag
     3181 gtccgtaacc agctctggcc gcacatccgc aagacgatct cccgcgcggg cctgcccggc
     3241 ttctgtgacg aagtgcagtg gaagatgccc gaccagtgga acaacgatgt ccgcgtggcg
     3301 tacggcttca ccgcccaggc ccacgacgag gcctcgatgc agggcatcca cggaaacccc
     3361 aagctcgtca tcatcgtgga cgaggccggc ggtatcgccc gcagcatcgg cgccggaacg
     3421 aacaacctcc tcaccggcga cgcgcgcatg ctcgccatcg gcaacccgcc caccgacgac
     3481 ccccgctcat ggttcgaggt catgtgcgag gagggcgacg accccgacga gcccggcacc
     3541 gtcaccatcc ccatcgccac gctcgactcc cccgcgatca caggcgagcg ggtcccgtac
     3601 tgcctggact gcccgtcggc cgtcgcccgg cactccctcg ccatccacct gcccgcccag
     3661 gactgggtgg accgcaccat ccgcgagtac ggcgacgacc acccgtacgt catcgccaag
     3721 gtgcacgcca agttccccaa gggcggcggc ggcaaggtca tccccaccac ctgggtggaa
     3781 gacgccaagg acaacgagga ccccaccggc cccggctggg tccgcctgtg cgacctcggc
     3841 ctcgacggcg agaaggccac ccacaccgtc aagcgcggcg cctgggtgcg cctcggcgtg
     3901 gacgtcgcag ccgacggcgg cgacgagttc accatctacc gcatcgtcgg cgacgtcgtg
     3961 gagcaccggc accactcctc cggcatggcc aacgacaacc aggtcaaggt cgccaagaag
     4021 atcctcgaag aggtcaaggc cgccgaacgc cttgccaagg ccctcggctc caccgccaag
     4081 gtccacgtca agatcgacaa gaacggcctc ggccacggcg ccgtcggcat gctcgaagtc
     4141 tggggacaga acggccgcca ccactccgaa gtcttcggcg tgatggtctc cgagtccccc
     4201 gaccgcgacg accccggcgc gcccatgcgc ccctaccgca agcgggacga gatgtggctc
     4261 gccacccgcc agctcctgca gcccgacccc gcaaccggca ccggccggct gcgtctgcgc
     4321 gtcgaccgcg aagccgcgat tcagctcacc acgcccaacc tcggcaacaa cgccggcgga
     4381 tacgccgtgg tggagtccaa gaagcagatg caggcccgcg gcatgaagtc ccccgaccgc
     4441 gccgaggcga tccttctggc catctacgag cccaaccccc gccgccgcgg catcatcgcc
     4501 tgaccggctg taacgaatcc tgcgcccacc acgtctatgc ggtgacgcgc cccgggagcc
     4561 tggacacctc ccgcgggcgc cgaccagctt ctggaagctc tggtgcgccg gccaccgtca
     4621 caagccgacg caccagcagc caccggccga gtaccccagc ccccgcggag gacaacaccg
     4681 tgagcgtcga gatcgaactc gtcggcggcc ccgcggacgg ccgccgacga gtccgagccc
     4741 gacgcacacc cttcaacccg cccccccgac atcaaggtcg ccgagctgct ccccggcgcg
     4801 ctccacgccc accacgacga cgtcgacccc gaccggcccg ccttccgggt cgtccgctac
     4861 gaccgggacc gtacgcccgt cgaccacgcc gacggcctga tctggcacta ccgccgcgcc
     4921 ccacacacga cgtgagccgc cgaggggagc gctcttgccc ccctcgacgg ctcacgacct
     4981 ggtcaacgtc ggttctgcca ccacacgacg gccacgctca cacacgccga ccccgccccg
     5041 gacaccatcc cgagcaggaa ccgacgccgg accaccctgg ccttacgccg gatcagctca
     5101 accttgcggc gcaccgccac ggcgagccgc tgccagcggc ccggagggtc cgaatcttgg
     5161 gaagacatgg gaagatgcat ggaggttctc caatcgttcg ctgcgagagg gaatcggcag
     5221 taaggaaccc cctgaggcgc aggagtggaa gccaggcgcc gaccgggggt ttcttactga
     5281 cggccgatag tgcgagttta cgtccgaaac accgccccgg taacggtcac cagcctccaa
     5341 ctcgcaagca cgcatggcct ttgatcttcc gtcagacgtg aaggttgttg gcgtttccgg
     5401 atgttgagag tcgtgaacat atccggacaa tctggtggcg tgaaagtgat tggtgtttgg
     5461 catatgccaa ttccccggcc ccgtcatcat ggacccgtga ccgactacac cgctctcgtc
     5521 gccgcggccg cgcacgccgc cggcccggcc cccacctccc ccagcggaga agcgggctgg
     5581 ctgacccgag tccagcacct cgcgaccgag ctcgcgttca ccgcccgcca ggtcgagcag
     5641 gccgtgcaga ccctcgacgc ctcccggccc ttcgccgcgt tcctggaacg cgtggagatc
     5701 gaggagagca gccgccgcgg cctgctcacg ctgcgccccg actccggcgt cgcggagacg
     5761 atccgcaccg agcaggacac caccctgtcc ggccgcgcca tgatcgagcg ggcgcgggag
     5821 ctcgaaggcc gctgggtgct cgtctaccgc tacaaccagc ccaagagcgg cgggaagttc
     5881 gagaacgtcc gcatggtcgc ccgcctcctc gacctcggcg aggggaccct cgccaaccag
     5941 gtcgcccgcc aggtcctcat cggggacgcg ggcggtgacg agcagcgcgc cgccgccgcg
     6001 tggaaggagg ctggtcttcc tctgtccggc tcgatcccgg tcgccgacct cgaaccggtc
     6061 cgccgcacgc tgcgcggcga gcagctgtaa cggatccgcg ccccaccccg tctacacggt
     6121 gatggtgatg ggggggtggg ggggccgcgc cccccgccgc gggcgggggg gggggggggg
     6181 ggggggggcg tcgtgcgacg ggggggggtg gtgggctgct ccgggggggg gggcgcgctg
     6241 ggggccccgc cccgccgtcg tgtgtcccgg tcgtcacgtg gctacgggcc actccagcac
     6301 ggtcagctcc ggccactgtt ggcgccagcg ctcggtcttg gcctcgtaca ccgcgcgcgg
     6361 cgcgagcacg gggttcggcc gtacgacgag cccgaacacg tcggacaggc cgtgcggtgc
     6421 gtacacccgc caccggccgt cgggctccag gcggacgccc agacagcagg tggtcgcggc
     6481 gaagctgtcg atcgccgcct cggtggaggt gtacggggcg caggggacgc cgaacttctg
     6541 ctcgtaccac agatgcacgc gggcctcgtt gcggatctcc acctcggcgg ggaggtccgc
     6601 gaaggtcgcc gccgcggcgc ggatcacctg gtcctccgcc tcccaggaca ggtcgcggtc
     6661 gtcgaagtag aagacgtcgt agtccttgat cccctcggcg ggaggtatgc ccgtgacgac
     6721 gttccacacg gtctggaaga gacagcccgc cgtcaggtac cagctgggcg gattcattgc
     6781 cgtggtccgg tcgagcacct ccagcagagt ctcgttgcga gacaacgtgc cgatgaaaaa
     6841 gccgagttgc tcgtccagcg gaaggcggcc gatcaccgtg catgtctacc acgaccaaag
     6901 cgtgaacact tttcgctgaa gtgctcacgc tttcgggcag gggcgcgtca gtgccgggag
     6961 gcgcagggca ggaaggtcgc ccatgcggac ggggtgaggg cgaggccgaa agggacccgc
     7021 ccgtgacgac actcgccgcc gaggctccct gcgtgctgcg cctggtcacc gaccggatgc
     7081 cggtcgagac gggcaagggg ttggggccgt agctgtaacg cgagctcatg tcggtcactg
     7141 tgcttttggg cgtgaacagt ggacgccgca atgtcgttcg accactcaga tgagcgacgc
     7201 ctgaacagcg agagccgaag cgttcacgct tttcggtgag ggtgtcattc cttgagggcg
     7261 cggcacggga cgtcgaggac gaccggcacg gcctccgtgt ccggtggcgg tgatggcaac
     7321 ggcttgcaac ccagacgcgg gacgacagca ccaccgacta cgcatcggac tgaccgatgg
     7381 cctccaccgt cctggtcgtc accgcactgg aggacatcac ggcggaccgg gtcgtcgccg
     7441 ccttgaacga gcgcgaggtg cccgtcgtcc ccgtcgatcc cgccgacatc gggccggccc
     7501 tgacgtcggc ttccgcctcg acgcggaccg tccggcatgg cgcggacggc tgcgtacggc
     7561 gccctgtccg cgtatctccc cggcagcacc gggactacgg ccaccgaggc gcggcctgga
     7621 cccggcggcg tcctgaacgc cctgtccggc gcacggtact tcaaccaccc ggccacggtg
     7681 gcccgcggag agtccaagcc cgcccagctc cgccggctcg cccggcgagc gccgagcaac
     7741 tggaaacctg ggaacagccg ttggacccgg tccgggtggt cattgtggaa ctcgcggcca
     7801 ccgccgttca ccacgggtgt gtggcagggc gcggttccgg ctcggtctca ccgtcgcgac
     7861 gcccggcacc ctccgcatcg aggtcaccga ccccgcggtg atcaactgcc cgcacccgaa
     7921 ggagcggtct gcggggcgga gcccggccgg tgaccgcggc cctctcaggc gtgtgggcct
     7981 gaagggacgg gctccatcac gcgccggacg gcggccgggc cgttcagccg ccctgccccg
     8041 cgctgccgat cgggccgacc tgcaccgggg tgccggagcc gtccgtgacg gggagggagc
     8101 cggcgcccgg ccagtcgagg gtgacggact tggtctcgtc cggcggggtg acgaccaggc
     8161 ccgtgacgcg gacgccggag ccgccggagt cgttgaccgg gtagacgacg gcgaaggaca
     8221 ccttctcacc gtccttgagg acgacagagg gggactcctc gccggtgcgc tcggcggaga
     8281 gcgagcccgc gctggtcttc aggtcgacgc ccgcgtagcc cgagagcgcg cagtcccggc
     8341 cgccgccgtt ggtgaacgtc accgcgacgg ttccgtcggt gtcgccgtcg atggtggcat
     8401 ccgtagccgt gacgtccagt tcgtcggtgc ggcacgtggc ggtcttgccg tcctcgttgg
     8461 tctcgactcc ggcgaccgtg ccgtcctgct gaccctgttc ctggcccgcg tcgccgttcg
     8521 cggcgggggc cgaggtggcc ggcttggggt cggcggcgac atcctcgttc tggcaggccg
     8581 tgagcgagag gcccgcgacg acggccaggg cggcgatggt gagcttgttg acgcgcatgg
     8641 tgtcttcctc ggtgtcggtg ggcgtgtgtg tgatggcccg tcagggcggt cgtagcgcct
     8701 cacaagagcc gccccgcccg ctcgccgttc cgctcgacgg cgcgcccgga cacgcctgtt
     8761 acaggcggaa gtgtgtgcgg tgacatctgt gccctgcccg gcacgcacgg cggtgtgccg
     8821 acgccgggcg ggccgggctc cggtgggccg gccgacgggg ccgcgggccg taaaagacct
     8881 aagtacctag ggtaaatacc gaccaaccca accaaacctc gtgttgatca ctcggctggg
     8941 tgaaacgtgt cgaactggct ggcgcggcgg tggtgcgggc gggcactctc aggtcagagg
     9001 gccgggccaa ctcggtgcct ccctgactcc gtacagacgt cggcccccgc cgggacgtag
     9061 gactcccgag cgagggcctg accaaagagg aagacaagcc ccttccccat ggctgaacag
     9121 aagcttagtg ctgccccgcg cccgattcag ggtgttccgc gatccgccac cccgtccggt
     9181 gtcacccacg tacgtacgtg cctatccggg cagtacgtgg tcgtcggcaa ccacctcgcc
     9241 cagcaccgtg agttgtcgct gaccgcgatc ggactggcga cccacatctt ctcggtgccc
     9301 gacggcaccc cggtcgacat ccgcagtctc gccgagcgct ttcccgaagg gcgggaccgg
     9361 atcgccttcg ccctgcggga gttggaggcg cacggctatc tgcggcgggt ccgtgagcac
     9421 acggaggacg gacggctggt gacgcggacg tacgcccacc acacgcccgt ggacgcggcg
     9481 tccgccgctg gcgcggagcc cgtgcgggcg gtggagcggc gttcgggaac gggccgtgcc
     9541 cgtatccgtc acgcggtgga ggcagtcggc ggtgagacac cccaggaggg cggtcaaacc
     9601 gtcgccgagc cggtggtccc ggccggtccg acggctccca cggtcccgga cgcgccggcg
     9661 cctgtgcctg aggcccccgt ctccgcagcc cccgaggtgc cgccgcagga gcccgcccgc
     9721 tccgcaccgc tgcacgagaa agcggtcgcg ctgctcgcag gcctgcgccg cgccgacgag
     9781 cgcctcacgc tgtccctgcg tgaggtgcgc cggctggccc cggccgtcgt cgactggttc
     9841 gaacggggcg tcggcccggt ggcgttgcgc cacaccctga ccgccgatct gcccgtcgtc
     9901 atgaagcacc cggcgggggt gctcgcctac cgtttgcgcg aactgctgcc cccgccgctt
     9961 ccagccgccc cggaacctcc accggtcacg ggccacgccc tcgctcggca ccaccttcgg
    10021 cgaccccgag caggctcgcg tcgccgcgat agccgagggg atggagcgct actgcggcaa
    10081 ccgtgtgccg ccgcccggcc acccggacgc acccctgcgc gccaccgccg ccgaactggc
    10141 ggacaagggc ctgcgcctgt acggcccggc cgatctgccc gcctacgcac cctggcagta
    10201 cgcccgcgcg aagttcccct accgcccgct caccgccgac accccggcac tgtggacacg
    10261 gggaaccgaa cgactgcccg acgggccccc cgccgaggtc tgggcacccg tctcgctcac
    10321 ccacctcaac tggcgccaag gcggcctgcg cgagctgccc cgcacccacc acctcaacta
    10381 cgccgggatc gccaccggac agggcctcga cgacgctgtc gagcgcggcc tgctggagat
    10441 cgtcgaacgc gacgccctgg aactgtggtg gcacctggac ggcccggccc ggggcatcga
    10501 cccggcgagt gtgcccggcc tctccgacga cctcgccggc tccgcgctcg acgtccacat
    10561 cgtcgagatg cactcggagt tcgccccctg catggccgcg ctcgtccacg acccgcgcct
    10621 cggcctgtac gccgccgggt tcgcctgcaa gtacgatccg gccgaggctg cccgcaaggc
    10681 cgtcctggaa gccgtccaca cctgggtctt cacccagggc ctgaccggcc ccgacggctg
    10741 ggtgttccag gccgtcgagg ccgggctgct cgcccgcggg ctgtacctgg accaccgggc
    10801 cgacggccgc tacctcgacg tgtgcggcga gcagttcgag cacgtgcgcg acctgggcgc
    10861 acacgtgcag gtgtggctgg acgagcggat ggcggtcgag gcccggaggt tcaccgagcc
    10921 cgcgctcggg acggtatccg tcgcagaggt cgagcccggc agccgggagc ggctggagag
    10981 cacgctgcgc gagggcggtc accgtgtcat gaccttcgac ctcaccaccg aggacgtggc
    11041 ggagaccgca ctgcgcgtcg cccgggtcct cgtctccgga ctgcttccca acgcgcccgc
    11101 cgccttcggc tacttcggct gcccgcgcct tgccgaggcc gccgtcgcgc gcggatggcg
    11161 cgcgaccgcg ccgagcgcgc cggaggattt cacgctggca cctccgccgc acatgtgagg
    11221 gccgctgtgg aagaccatcg cgaggacccg cagacgggcc tcgtcgccgc cctcgcccgg
    11281 gcccgctccc cggagcgccc cggccccgac acgcccgcgg gagcacccgt ccgggcctgg
    11341 gcgggcccgc cgctcccgat cccgcaggcc ggccccgcgc acctcgacct gcggactctg
    11401 ctgcgtctgt ccctggcggc ctcggacacc tccggacgcc tcaggcccac gccctccgcc
    11461 ggtgcgctgc acccggtgga caccgaactg gtcgtgggca ccggctgctc cctgccgccc
    11521 ggccgctacg gctacgaccc gctgcgccac cgcgtccatc acgtcggccc gcccgtcgac
    11581 agcacgccgc cgggcgtgac cgccgcactt tccgtcaccg cacagcgcac ggtgtcgcac
    11641 tacggccacc gggcctggcc gctcctgttg ctggacaccg ggcacgccgc cgcggcgttg
    11701 ttcctggcgg cccgcgtcct gggcgcgggc gaatccgacg tgcggatgga cggacgcacc
    11761 gagaaccccc tggccgtcgt acgtatccga ccgccctacg ggcggagccc gagacactct
    11821 gcggggactg aggacccgcc cgccccggcc gacctgctgg cgcgccgcag caccccgcca
    11881 ccgttggtgg gccttccgcc ccgcgacgca ctgcgggcag tcctgtccac cgccgaacga
    11941 gccgggggcg gtgacctgtt gcgctggtgc gccgcggtcg gcccgcctcg gcccggcctc
    12001 atgcaactgg gtcccaaggg cacgaccctg cggcgctacg cgtccggcga ggcccgtccg
    12061 acgctcgcgg cctgggcggc gggccaggcg tggctcgcgg acgccggcgc cgtactgctc
    12121 gcccacggct gccccgcgga cgccgacgcc acgcacatcc gccgcgccca tctgcgagcc
    12181 ggcttcgccg tccacctggc ccatgtcaca gccctgcgcc acgggctggc ggcccgaccc
    12241 gtcggctcct ggcagcaggc ggatctcggc gccgctctcg gcgccccgcc gggccgtgac
    12301 tgggtcgtgc acgccctggc cctcggcacc caccacgccg acgaggagag ttccacatga
    12361 tcgtccaccc cgagctgcgt cgcgccgcac ggcacgcacg gcggcccctg ctcgcggcca
    12421 ccctcttgca gggagccgtc accctcacat acctggcaca ggccgtcctg ctggccctcg
    12481 cgctcgccgg cctggcccgc ggtgacaccg gccgactccc gtggctgctg gcaggcgtgc
    12541 tcgccgtcgt cgccgcccgc gccgagctcg ccctgtggca gcggcgcacc gccacgcgcg
    12601 ccggggcccg ggtcagggtg gcactgcgcg acgaactcct ggcccacctg ggccggctgg
    12661 ggcccgcata cctgaccaca gcgcgggcgg gtgccgtccg caccaccctg gtcgacgggg
    12721 tggagggcgt cgacgcctac gtctcccgct acctgcccca gctcctggtc accctcgcgg
    12781 taccacccct ggtcctcgcc gtcctcgtcg tggtcgaacc cagggccctc ctcgggctcg
    12841 tccccgccct gctcctggcc ctgctggggc cgcgcgcctg ggaccggctc ctcgccgccc
    12901 gcgggaagga acactgggac acctacgaag ggctgggcgc cgactacctg gaggctctcc
    12961 agggcatgcc cgccctgcgc gccgcgggcg cggtcggccg cacccgggcg cgcctggagg
    13021 agcggtccgc ggccctgcac cgggcgaccg tcgccaagtt gcgggtgtcc ctggccgaca
    13081 ccggcatcac cgacctcgcc atccagggcg gcaccgccgc cgcagcgctc ctggcatgct
    13141 ggtcggccgt caccggatcc accaccgcgg ccggcaccta tctggtgctg ctgctggcct
    13201 ccgagtgctt ccgtccggtc cgcgaccatg cccgggagtg gcacgccgga tacctggggg
    13261 tgtcggccgc cgacgggctg gcgtccctgc gcacgtccgt gccggcggtc cccgacaccg
    13321 cgacggcgcc cgcgcactgg cacaccccgc ccgaactcag ttttcacaac gtccggttca
    13381 cctacgacgg tgctgacgca cccgctctgg acgaggtctc cttcaccgcc cgagcgggac
    13441 ggaccaccgc gatcgtcggg ccgtccggcg cgggcaagtc gaccctcctg gccctgcttc
    13501 tgcgccacca cgacccgcag gaagggcgga tcaccctcga cggccgtccg acgaccgagt
    13561 acgcgctcga ctcgctgcgg cagggcatcg ccgtcgtctc ccaggagacg tacctgttcc
    13621 acgccaccat cgccgagaac ctgcgcctgg cccgtccgga cgccaccgac gacgagctca
    13681 cccgggcggc gcgcgccgcc gggatccacg acgagatcgc cgccctcccg gacggctacg
    13741 ccaccctcct cggcgaacgg ggcgccacac tctccggcgg gcagcgacag cggctcgccc
    13801 tcgcgcgggc cctgctgtcc gacgccccgg tcctcgtgct cgacgaggcc accagttcgg
    13861 tcgacgaacg acgcgaggcg gacatcgtcc gagagctgct gaacgcggtc ggtgggcttt
    13921 cgttcggatc aggccggttg tgaggcgcgg tgcgtcttcg gccgacccga gcggggtctg
    13981 gtgcgtgcag ctgcaaggcg gaggagggcg tcaacgcgga gcgttggcaa ccgacgacaa
    14041 cgccgcaggt gtgggtgcca gggcccgcga cgccggggtg atccgaacgg aaggccctga
    14101 gggcgtcgag ccccgcctcc gcacaccctt gtcacttcct tctccgcgct ggagcgacgc
    14161 atcgcgccgt ccgctcgcgc gaagatccgc cctgcccttg ggagttccgt catgcctgct
    14221 gccgccaccg ccaccgccgt cgccgccgag ccctccgtct gcgccccgct gcccgtcctc
    14281 ggccgggacg tcgccgtccc cctcgtcacc ggcggcgagg tcacctacgc cgccctcgac
    14341 caagccgcca gcgcccccgc cctccagcgt gtctgggacg acgtggccgc ctacgcccct
    14401 tactacggca gcgtgcaccg cggcgccggc tacctctcgc agctctccac cgacctgttc
    14461 gagaacgccc gccgtaccgt ggccgagttc ctcgactgcc gggacgggga cgaggtggtg
    14521 ttcacccggt ccaccaccga ctccctcaac ctgctcgccg ccgccctgcc cgacggctgc
    14581 gaggtcttcg tcttcgagac ggagcaccac gcggcgctgc tgccctggct gcgggcgggc
    14641 cgggtgacct tcctcgacgc ccccgacagc cccgcgcagg ccgtcgcggc cctggagcgt
    14701 gccctcgccg accgggaccc ttacggcccc gccctggtct gtgtcaccgg cgcctccaac
    14761 gtcaccggcg agctgtggcc ggtccgcgaa ctcgccgccg ccgcacacgc gcacggcgcc
    14821 cggatcgtac tggacgccgc ccagctcgcc ccgcaccgcg cggtgtccgt gcgcgagctg
    14881 gacgtcgact gggtcgcctt ctccgggcac aagctgtacg cgcccttcgg ctccggggtg
    14941 ctggccgggc gcgccgactg gctgcgcgag gccgagccgt acctcgccgg cggcggcgcc
    15001 agccgcacgg tcgtccggcg cgcggacggg ggcgtggacg tgcggtggca cgagaccgcc
    15061 gcccgccacg aggccggctc gcccaacgtc atcggcgcct acgccgtcgc ctccgcctgc
    15121 aaggcgctca ccgaggcggg gttcgaggcg ctggccgcgc gcgaggacgc gctggtgcgc
    15181 gccgtgcggg aggggctggc ggacgtgccc gaggtgcgct tcctgtccct gttcggcgac
    15241 gacgcgcccc gggtcggggt gctgtccttc gtggtcgacg gctggaacag ctcccacttc
    15301 gcggcggcgc tgtccgcgga gtacggcatc ggggtgcggg acggtctgtt ctgcgcgcac
    15361 ccgctggtgc ggaggctgct gggcggcgac acgggcggtg cgggggagtg cggggcgccg
    15421 gagccggggg cgctgaacgc gatccgggtc agcttcgggg ccgggacgcc ggaggagcat
    15481 gtcgcacggt tcgtgcgggc ggtgcgggag ctcgtgcggg acggggcgcg gtggacgtac
    15541 cggacggtgg acgggcggtg cgtgcccgac gcgtggggac gcgcgtgagc ggttctcgcc
    15601 cccgccgccg cttcccgtcc tgtccctggg ggctgcgccc ccagaccccc tcgtcctcaa
    15661 gcgccggacg ggctggaatc agccccttgg gcgcttgagg agcggggttc ggggcggagc
    15721 cccggcaggt cagctgtcca gcccgatggc gaaggcagcc tcgagatcgt gctgggagta
    15781 cgtccggaac gccacatgtg tgtccgtgcc ctccaccccc gggatcttgc tgatcctgcc
    15841 ggggatcacc tcggcgaggt cctcgtgctc ccgcacccgc accatggcga tcaggtcgta
    15901 cgtgccggtg acggagaaga cctcgctgac gctgtccagc gcggcgatct gttccgcgat
    15961 ctcggggatc cggtccacgc tggtcttgat gaggacgatc gcggtgatca cggctggttc
    16021 tctccctcgg gggccggagc aggggcgggc ttcactgtag tcgccccgcc gcgccacacc
    16081 cacgcgcagc cgaagcccag cgcgaagccc agcaggtgcg ccagataggc caccccgggg
    16141 ccgccctccg gcgtccgccc ggccgccgcc cactgcagcg ccgcccagaa cggcagcacc
    16201 gcccacgcgg gcagccgtac cggcaggaag aaggcgaacg gcaggagact ggtgacccgc
    16261 ccgcggggga acaggaagag gaacgctccg agcagcgccg agatcgcccc cgaggccccg
    16321 accagggacc gctcggagcc ggcgttggcg gccgcgtacc ccagcagggc gaggtagccg
    16381 cagccggcgt agcagagggc gaaccgcacc cggcccatcc gcgcctcggt cagcggcccg
    16441 aacacgtgga ggaacagcat gttgcccagc agatgcaccc agctgccgtg cacgaagagc
    16501 gccgtggcgg gcgtgagcac ggccgcgggg gacccgtcga acaggtctgc ggggatcacg
    16561 ccccagcggc ggaagtagtc ccgctgcgcg gcgagcagct cctcgccgga gccgtgcgcc
    16621 ggatgcagcc ccgaggccgg cccgatcagg aagaccaggc agcacagcac gatcagggtg
    16681 cgggtgaccg gggcgggcgt ggtcctcagc gccccggcgg ccgccgcggt ccggcgaccg
    16741 ggtgctgcgg gcggctcgcg gtggtcgggc tggggcccgg cgcgcgggac ctgctcaccc
    16801 cgcgtgcgcg ggacgaactg cggcgcgcgt cggtgctggt gggcctggac cagtacgtcg
    16861 accagatccg cgacctgctg cggcccggca cccgcgtgct ggagtccggg ctcggcgcgg
    16921 aggaggagcg ggcgcgtacg gccgtcgagg aggcccggcg cgggcaggcg gtcgcgctga
    16981 tcggcagcgg cgacgcgggc gtgtacgcga tggcgtcccc ggcgctcgcg gaggcgtccg
    17041 acgacatcga cgtgatcggc gtgccggggg tgacggcggc gcccccggcg ggggccgtgc
    17101 tgcgggcccg gccgggccac gccgtgggag gtcatcgagc ggcgggtgcg ggcggcggcc
    17161 gaggcggacc tggtggtgac gttctacaac ccgcgcagcc ggggccgtga ctggcagctg
    17221 ccgaaggcgc tcgccgtgct cgccggacac cgcgcgcccg ccacacccgt cggaatcgtg
    17281 cggaacgcgt cccgcgcgga cgagtcggtg cggctgacga cgctggccgc gctggacccg
    17341 gcgacggtcg acatgatgac ggtcgtgacc gtgggcaaca cggcgacccg gcagatcgcg
    17401 gggcgcatgg tcaccccgcg cggctaccgc tggcaggagg agacccggtg aaccgcgtga
    17461 tccaccccat cgaacaggag tcgttccggc ggttgcgcgc ccgcctcgac acctccggcc
    17521 tccctccgct gacccgggcg gtcgtggagc gggtcgtgca ttcctccgcc gatctggagt
    17581 acgcgacgga cctcgtcgtg gacgaggccg agctggagcg cgcgcacacc gcgctgcacg
    17641 cgggcgcgcc cgtcgtcgcg gacgtggaga tggtcgcggc agggatcacc cgccgcgaga
    17701 ccgtgtgccg gctgcgcgag gcgcggtccg ggccagggct cacccggtcc gcgcacgccg
    17761 tgcggctcgc gtacgaggag gtcggacccg gcgccgtgtg ggtgatcggg tgcgcgccca
    17821 ccgccctgga ggagctgctg accctggaca cctcccccgc gctggtgatc ggcctgcccg
    17881 tcgggttcgt cggcgccgcc gagtccaagg cggcgctgcg ggagagcgga ctgcccgccg
    17941 tgagcaacgt gtccgagaag ggcgggtcgg cggtagccgc cgccgcgctc aacgccctgc
    18001 tgtaccaccc cgcttcgacc gaggagacct tgtgaccacc ccgcccgccc tgctcatcgc
    18061 cggccacggc acccgggacg acgccggagc ggaggcgttc cgcgcgttcg tgcgggaact
    18121 gggccgccgc cggcccgacc tgcccgtcgc gggcggcttc atcgaactgt ccccgccgcc
    18181 gctgggcgag gccgtcgccg agctggtgga gcggggggtg cggcggttcg cggccgtgcc
    18241 gctgatgctg gtgtccgccg ggcacgccaa gggcgacatc ccggcggcgc tggcccgcga
    18301 gaaggaacgc caccccggtg tctcgtacac gtacggccgt ccgctgggcc cgcatccggg
    18361 tctgctgcgg gtgctggaac ggcggctcgc ggaggcggtg gacccgtcct gggaccccgc
    18421 cgaggtgacg gtgctgctgg tggggcgcgg gtcgacggac ccggacgcca acgccgaggt
    18481 gttcaaggcg gcccggctgc tgtgggaggg acgcggatac gcgggcgtgg agacggcgtt
    18541 cgtgtcgctg gcgaagccgg acgtgccggg cgggctggac cggtgcgccc ggctgggggc
    18601 gcggcggatc gtcgtcctgc cgtacttcct gttcacgggg atcctgccgg accgggtacg
    18661 gacgcagacg gaggagtggg cggcggcccg cccggaggcc gaggtgcggt cggcggacgt
    18721 catcggcccg gagccggagc tgctggacct cgtcctcgag cggtacgagg aggccgtgaa
    18781 gggcgatctg cggatgaact gcgactcctg cgtctaccgg atcgcgctgc ccggcttcga
    18841 ggacaaggtg ggactgccgc agcagccgca cttccatccg gacgacgacg ggcaccatca
    18901 tcacggacac ggtcactcgc actcccacag ccatgcccac tgagccggcg tccggccacg
    18961 acctgcgtca tcacggcgac gcggaggtcc gcgacggcgg cggcacgctc gtcgacctcg
    19021 cggtcaacgt ccgcgcggac acgcctcccg cgtggctgcg ggcccgcatg gcggcgtcgc
    19081 tggccgggct cgccgcctac ccggacgggc gggccgcgcg ggccgcggtg gctgcgcggc
    19141 acgggctgcc cgtggagcgg gtgctgctga cggcgggggc ggcggaggcg ttcgtgctgc
    19201 tggcgcgggc gctgaaagtg tcacggccgg tggtggtgca cccgcagttc acggagccgg
    19261 aggcggcgct gcgggacgcg gggcacacgg tggaccgggt gctgctgcgg gagtccgacg
    19321 gcttccgcct cgatccggcg gcggtccccg aggaagcgga cctggtggtg gtcggcaatc
    19381 cgaccaaccc gacatcggtg ctgcacccgg cggagacact gacccggctg agccgtcacg
    19441 ggcggacgct ggtggtcgac gaggcgttca tggacgcggt cccgggcgaa cgggaggccc
    19501 tggccggccg gacggacgtc ccgggcctcg tcgtgctgcg cagcctgacc aagacgtggg
    19561 gcctggccgg cctgcgcatc gggtacgtgc tggcggcccc ggagaccgtc gctcagctgg
    19621 agcggtcgca gccgctgtgg ccggtgtcga cgccggcact ggtggcggcg gaggcatgcg
    19681 tgtcgcccgc ggcgctcgcc gaggcggagg aggcggcgcg cgttgtcgcg gcggaccgcg
    19741 cccacctgat cgcgggcttg cgggacttcg cgtcccacgg ccttcgggtg acggacccgg
    19801 ccgaggcccc cttcgtcctg gtccgcgtcc cggctgcggc ggacgtgcgg gagcggttgc
    19861 gctccctcgg ctacgcgacc cgccggggcg acaccttccc gggcctcgac gaggagtggc
    19921 tccgcctggc ggtgcgggac aggaagacga cggaggggtt cctgcgggcg ctggggcggg
    19981 cgctgggcgc ctgaccgccc cgcgggtggt ccgtggcggg tcgcgcagtt ccccgcggtg
    20041 cggagggcgc cggggacggc ggcgggggaa gaggcggagc gccgtgggcg gcgcccaccg
    20101 tgaccgcggt gtccgcgacg gcaccgccgg cgacccaccc gcccgtactc gcccctgcga
    20161 acacatcgga ttccggccgc ggacccgccg cgtcgtaccc ggcgaacagg tcggtcagcc
    20221 ctgccggagg ctcccgccac ccggacgggg ccggcgcggg ctggctgcgc ccgatacgga
    20281 ccgaccgcag ccggggaaga tcggtacggc gccgcagatc ggccgtggcg aaggcgatcc
    20341 gcacgcccgt ccagtcctca ccggaccgct gcgcgaccga ggcccgcagc agcagccgtc
    20401 cactgtcctc accctgacgg tgcgtgaggc ggtacgccgg cacccagacg gcgccgggca
    20461 ccccgtactc gatctcgacc tccgcctcgg ccccgggcgc gccgcgcagc gtcagcaccg
    20521 ccgtgtacgc ggaggcgacc cctgaggccg gcgcgtcggt gctcacgcgg gccagccggt
    20581 cctgcgccac ctccatctcg tgttccagac gcccgagttc gtcctccagt tcgcggagcc
    20641 cgtcgtgcag cacggtcagg cgctcgtcga cgaagtcggt cagctccagc caggcgtcca
    20701 caggggtacg gcgatgcggg tcctcgcgct tgcggccggg cggcaccgga cgcagcgcgc
    20761 cgacctcctc gatgcgcttc aactgccgct cccgccgggc gtcggcggcc tggtacgcct
    20821 cggtcagccg gtcgacctca cgccgcgccc cggcgacggt gtcctcgtcc accggctccg
    20881 cgtggatctc cgcccgcgcc tcggtggccc gcgtccccgg cgcaccgatg acgcgggcgc
    20941 gcagcgagtg ggggtcgagc gagcgcggca gtccgggcac ccgtacctgt ccgtccgcgg
    21001 ggaccgtgcc ccgggcgacg cgacggcaca gcgcgccctg cgcgtacacc gtcaccgatt
    21061 cgagtgccga gtcccacctc ggtgccgtcc cagccgtcat gtgctccccc gcgcagccgt
    21121 gttcgtcccg agggcagcct acgcggagac ggcccgcccc ggatcaccag aggaggcacc
    21181 agtacgcgcc gtggtgcccg atcccgatcc ggctctcgcg cggcaccagg gcggggtcgg
    21241 gccgccccac ggccgacagg gtgcaggcgg ggtcgccgac ggtaccggcg gcggacatgc
    21301 ggcgggcggc gtccgtggcg gcgggggagg tgtaccagaa gggggtgggg gtggcgcggg
    21361 ccgccgcggc catggtgtgg ttgtcgcccc ggcagcgggt gcgggcgacc tcggtcgcgg
    21421 ccgccacgag ttcctcgtcg acgtcgtgcg tgtgcatggt ccggcgtgcc ttcccttacg
    21481 gtccttggcc tgtaccagaa ggaccgtgct gcgtgacggg cgtcgtgcgc aagccggttt
    21541 ccacgggtca ggggtgttcg ggggccgtca gccaggccac cagcgtgcgc cagcgttccg
    21601 gttggccggt gtcccgcggg ccgaccaggt acacctcctc cacgatgttc tgcgcgcgca
    21661 ggccgtggcg cgcggcgaag gagcccacgg cggcgtaggt caggtcgagg tcgtcgtgcg
    21721 ggccggtgtg ggtggcgacg gcggccgtcc gggccggcag gtccagctcg cgcacggtgg
    21781 ccggggctcc cgggggcagc ggggtctcgg cgggcaggta gacggtggcg tggccgtggc
    21841 cctcggtgaa cagttcgtgg gtgtagcggc cgcccggcgg gagcaccggg cggtgtccgg
    21901 cggcggcgtc gaggtcgcgc atcgccgcgt cgtaccagtc caggccggcg ccctcgggca
    21961 cgtcgaggga gaccgcgtac acccgctggg gcgggaggag ctccagcgtc accgtccgtt
    22021 cggcgccggg gtcgaggagt tcgcggagtg tttcgacggc gcgctgggtg cggccgaggc
    22081 ggtcctcgag ccggcggagg tgggcggcca cgacctgccg ggccgtgtcc cggtcggccg
    22141 ccccgccgtg tgcgccggtc tccgcctcca ggaagcggcg caggtccgcc agggggaggt
    22201 cgaggtcgcg gaaccgccgg atggtctggg cgggccgtac ctggccgggc gagtagtagc
    22261 ggtagcccgt caccgggtcg acctcggcgg ggaccagcag atcctgctcg tggtagcggc
    22321 ggagcgtgcg gatgctgagg tgggtgatgc gggagaactc
//
