LOCUS       NZ_RAII01000001        23435 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5178011
            Orig. end                         :: 5201446
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23435
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="23"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23435
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23435
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[<10000:13435]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <10001..13435
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            71..730
                     /locus_tag="EBH12_RS24495"
     CDS             71..730
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976804.1"
                     /locus_tag="EBH12_RS24495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator"
                     /protein_id="WP_033273066.1"
                     /transl_table=11
                     /translation="MSAPESPQPADVPDDDKSHVPPMTTRVVIAEDEALIRLDLKEMLE
                     EEGYTVVGEAGDGEQAVELAREHRPDLVILDVKMPKLDGISAAEKIAEESIAPVLMLTA
                     FSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFTELKELEREVADLSQRLETR
                     KLVDRAKSVLQTQYGLSEPAAFRWIQKTSMDRRMSMQQVAQAVIDDAEEKKAAKGG"
     gene            complement(797..1513)
                     /locus_tag="EBH12_RS24500"
     CDS             complement(797..1513)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015032843.1"
                     /locus_tag="EBH12_RS24500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_006135514.1"
                     /transl_table=11
                     /translation="MTALLEVEDLKVAYGKIQAVKGISFSVEAGEVVTLIGTNGAGKTT
                     TLRTLSGLLKPVGGQIKFNGRSLKRVPAHKIVSLGLAHSPEGRHIFPRMTIEDNLRLGA
                     FLRSDKQGIEQDIRRAYDLFPILGERRKQAAGTLSGGEQQMLAMGRALMSRPQLLMLDE
                     PSMGLSPIMMQKIMATIAELKSQGTTILLVEQNAQAALSLADHGHVMEVGNIVLSGTGR
                     DLLHDESVRKAYLGED"
     gene            complement(1510..2616)
                     /locus_tag="EBH12_RS24505"
     CDS             complement(1510..2616)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525491.1"
                     /locus_tag="EBH12_RS24505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_121740509.1"
                     /transl_table=11
                     /translation="MTTDTITKDSAAGPPAPGSVVLDARGVTMRFGGLTAVKDVDLTVR
                     SGEIVGLIGPNGAGKTTFFNCLTGLYIPTEGEVRYQDKVLPPKSFKVTAAGIARTFQNI
                     RLFANMTVLENVLVGRHTRTKEGFWSAVLRGPGFHKAEAASRARALELLEFVGLAEKAD
                     QLARNLPYGEQRKLEIARALASEPGLLLLDEPTAGMNPQETRAAEELIFAIRDQGTAVL
                     VIEHDMRFIFNLCDRVAVLVQGQKLIEGDPATVQGDERVIAAYIGEPLADDPGAAEVAE
                     VEAAEAAAEAAGRPQSSAKTAGAPAPAGEAAEETAEADPRPEAAAEAGHSADAEATDAE
                     TTDAETEAQAEAEAEATTDTAPGKENDR"
     gene            complement(2622..>4166)
                     /locus_tag="EBH12_RS24510"
                     /pseudo=""
     CDS             complement(2622..>4166)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016826730.1"
                     /locus_tag="EBH12_RS24510"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="VTPAGADAAVKYAVLGTFATAWYTVVSISVELGGVVNLEPGGYVV
                     AAATLTALIGALALPFERPEPDPIDPEANGWEQFTHDAAHTMAVLRAAFASGSPRPVRT
                     LPSYAEILIIVAVLAVALIVFTYGIGTEYDELFVGFLITAGFGFGALNRSGLIAHASQI
                     SARHQNITVCGAFIAAALFPFTQTDDQYATLGVYILIFATVALGLNIVVGLAGLLDLGY
                     VAFLGVGAYAAALVSGSPSSPFGVHFPFWAAVLVGAIASLVFGVLIGAPTLRLRGDYLA
                     IVTLGFGEIFRIAVNNTDGTSGPDITNGSNGIASIPDLNILGFDLGVAHDIGGFTIGRF
                     ANYFFLMLLITAVVVLVFRRSGDSRIGRAWVAIREDETAALAMGINGFRVKLVAFAVGA
                     TLAGLAGTVQAHVTYTVTPEQYLFAGTTPPNSAFLLAAVVLGGMGTIAGPLIGAALLFL
                     IPNKLQFLGDYQLLAFGLALVLLMRFRPEGLIPNRRRQLEFHEEADAPTVLSKTGA"
     gene            5302..5754
                     /locus_tag="EBH12_RS24515"
     CDS             5302..5754
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527317.1"
                     /locus_tag="EBH12_RS24515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phospholipase"
                     /protein_id="WP_114875676.1"
                     /transl_table=11
                     /translation="MHRRLAAALATPALALVGVLGTATAADAAPADKPQVLAGWTQTSA
                     SSYSQWAAARSNQGAWSAYGFDWSTDYCSSSPDNPFGFPFSSACARHDFGYRNYKAAGS
                     FSANKSRLDSAFHEDLKRVCNGYGGATKSACNSTAWTYYQAVKAFG"
     gene            complement(5861..7927)
                     /locus_tag="EBH12_RS24520"
     CDS             complement(5861..7927)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947233.1"
                     /locus_tag="EBH12_RS24520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_121740510.1"
                     /transl_table=11
                     /translation="MAVTATPPTVRPETVPSRAGAAAVTTALVLLVAALAVVDVTQGTA
                     AVGPAEVLKALTGRADPGDASVVIASRLPRMAAGLLVGAALGVAGLALQAVSRNVLASP
                     DTLAVNAGSYFALGVVAVTGLSLPLIASSAVAFAGGLGAAAVVLGLSGLGAGTVRLVLA
                     GTALALGLTAVTEGLLLLFPEETEGLYQWNQGSIGQNGFDGVLQMLPVVVIGLAGLFLV
                     ARRVDALALGDDTARGLGVPVRATRVTAVVLATLLSAAAVTLAGPIGFVGLCAPALARP
                     LARWVRGVRRLRAGAAVTGLVGAALVLGADVLLRAMIDADTAVAVPTGVVTSFVGAAFL
                     VVMAARLRDTGGTAASDRLSIRSRRVFVLTLTALVFALAGVAVAGLLLGDHKLLLGDVA
                     HWAQGNAGRTVSFVLDTRTPRVLAALLAGAALALAGTLVQAVTRNPLAEPAVLGVSGGG
                     ALGAVVLVTTVPMAGGWSVSAAAFAGSALTAVLVFGLAARGGFQQNRLVLVGIGVASGT
                     TAVISLLIVLTDPFNATKALTWLSGSTYGRDLPDVLPLAAVLAVGVAAAGVRHRELDLV
                     SLDEDTPRLLGLDLARGRLGFLVLSVLLTATAVAAAGTIGFVGLVAPHAARALVGRRHT
                     RVLPVAVLLGAVLVCTADLLGRTVIAPAQLGAGLMTAVIGTPYFLYVLVRARR"
     gene            complement(7931..8911)
                     /locus_tag="EBH12_RS24525"
     CDS             complement(7931..8911)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527315.1"
                     /locus_tag="EBH12_RS24525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_048454800.1"
                     /transl_table=11
                     /translation="MRRLLRTAPLAAAAALLLAACGTTEPAADEAPKASAEPITLTDAS
                     GAKVELDGPAKKVVGTEWNVVEHLLSLGVEPVGVADVKGYKTWDSAVPLTNDAKDIGTR
                     GEPSTDTIAALNPDLIVATTDLQPNAVKQLRKIAPVLEVKSADASDPVGQMLENLDLIA
                     KATGTTEQAATLKKDFDAKLAEGAKALEDAGLKGAEIAFSDGYVVSNQVSLRPYTSGSL
                     IGGVNERLGLKNAWKLKGDEAYGLAATDVEGLTALGAVQFAYIGNEQDAASDPFGNELK
                     NNAVWKSLPFVKSGDVHRLDDGIWMFGGTGSMERYVDALVAALTK"
     gene            complement(8908..9762)
                     /locus_tag="EBH12_RS24530"
     CDS             complement(8908..9762)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004935896.1"
                     /locus_tag="EBH12_RS24530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_114875675.1"
                     /transl_table=11
                     /translation="MIPGEDASSGLRGHELAATGVTVAYDGTDVVHAAELTLRPGEVTA
                     LVGPNGSGKSTLLRTVARLQRPRHAVLTLDAATDALALGPREFARHVALLLQSRPTPSG
                     LSVRDVVEFGRYPHRGRWGGTDPGGRAAVDRALALTGVTDLADRGAEHLSGGQLQRVWL
                     AGCLAQETGVLLLDEPTTYLDLRYQVELLDLIRDLADDQGIAVGVVLHDLDQAAAVADR
                     IVLLADGRVVAEGAPEAVLTPERLTAVYGIRIEVDTDPLTGRLRTRALGRHHTRSERLS
                     TTS"
     misc_feature    complement(9745..9760)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    complement(9767..9785)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 26.03"
                     /tool="antismash"
     misc_feature    9769..9786
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            complement(9853..>9999)
                     /locus_tag="EBH12_RS36720"
                     /pseudo=""
     CDS             complement(9853..>9999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527313.1"
                     /locus_tag="EBH12_RS36720"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="spore photoproduct lyase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="QPGLQETKRSQNGALNLRYHAGVKRQALAGLRELIERRTPWLGVR
                     YAF"
     gene            complement(<10001..10630)
                     /locus_tag="EBH12_RS24540"
                     /pseudo=""
     CDS             complement(<10001..10630)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379578.1"
                     /locus_tag="EBH12_RS24540"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lycopene cyclase family protein"
                     /pseudo=""
                     /sec_met_domain="Lycopene_cycl (E-value: 1.8e-40, bitscore:
                     137.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAGTRTETTGRADPHGVVPGAAGLSLAHRLAGPGSGRRAPSVAL
                     LDAPPGPLRPPRRTWCFWEAGPGRFDAAVTASWRSLRVRDRGGRLIDGDIAPLRYKMIR
                     SDDFEHLVARDLAGHDGVRRVEGTVDTVEDVPGGALVRLRDRDGAPRVVGARWVFDSRP
                     PGSLPAARTTLLQHFHGWFVRTARPAFAPHTAELMDFRTPQPADGLS"
     gene            10900..12444
                     /locus_tag="EBH12_RS24545"
     CDS             10900..12444
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525635.1"
                     /locus_tag="EBH12_RS24545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene desaturase"
                     /protein_id="WP_114872846.1"
                     /sec_met_domain="DAO (E-value: 2e-16, bitscore: 59.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTVPGRTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDGLPG
                     GRAGRLELDGYRIDTGPTVLTMPGLADEPFAAVGDSLRKRVELVPLHPAYRARFADGSS
                     LDVHTRAEPMAAEVERFAGAREAAGYLRMREWLERLYRAQMRRFIDANFDSPLGLLHPD
                     LARLAALGGFGRLDARIGSFLKDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAG
                     VYFPRGGMHALPQAMADAAADAGADLRFGREVTRLERSGGRVTAVVAGEERIPCDAVVL
                     TPDLPVTYRLLGGAPRRPVRLRHSPSAVVLHLGTDRTWPELAHHTISFGEAWRGTFDEL
                     TRAGRLMSDPSLLITRPTATDPSLAPPGRHLHYVLAPCPNTDIGPGAAEWTDLAPRYRD
                     TVLRTLEGRGLTGLASAIETECVVTPADWTAQGHAAGTPFATAHTFAQTGPFRPRNLVR
                     SAENAVLAGCGTTPGVGVPTVLLSGKLAAARITGADGPVGRASTSSSAQEALHDRA"
     gene            12431..13435
                     /locus_tag="EBH12_RS24550"
     CDS             12431..13435
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525634.1"
                     /locus_tag="EBH12_RS24550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_114872847.1"
                     /sec_met_domain="phytoene_synt (E-value: 5.2e-119,
                     bitscore: 395.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-61,
                     bitscore: 207.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERELDAAGITDPVLREAYDHCRRLNARHGRTYFLATRLLPVER
                     RPAVHALYGFARWADDIVDALGTGADTGRRDAELAALERELAKGLRDGKSAEPVVRALA
                     DTARRYGIDHAHFADFMTAMRSDLVVTDYADYAALRRYMHGSAAVIGLQMLPVLGTVTD
                     RDTAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRERLRWSRDTGRR
                     DPRITSALRAFERLTRGVYRQAAPGLAMLEPVSRPCIRTAFVLYGGILDAVAEDGYAVL
                     HRRSVVPRRRRAVVAADGLARVAAARLRARSAARGTERAPLTAPEPRMVEEVA"
     gene            13435..14439
                     /locus_tag="EBH12_RS24555"
     CDS             13435..14439
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525633.1"
                     /locus_tag="EBH12_RS24555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_121718978.1"
                     /transl_table=11
                     /translation="MAGDGRRRRLPLSLRRNAVAWERQRPTWRDAKPALIAGALKRAQA
                     RPSGNWYVVGSSRDVGGDRPLGRTVAGQEVVVWRDTGGRVVAGPGVCPHLGAPLRDSPV
                     RCGTLVCHWHGLSLDGGPFAGWEPFPAYDDGVLVWVRLDAVGGEEPLDAPVVPSRPVPA
                     RALTAVYAGVGVCEPEDVVANRLDPWHGAWFHPYSFVDLTVADTPESAGEDAFAVDVSF
                     KVAGRLVVPVRAVFTAPEPRTVVMHITEGEGVGSVVETHATPLGPDVSGRPRTAVVEAV
                     VAASDRRGFALARAAAPVLRPLVRAASGRLWRDDLAYAERRWALRSTGRFPGA"
     gene            complement(14935..15813)
                     /locus_tag="EBH12_RS24560"
     CDS             complement(14935..15813)
                     /NRPS_PKS="Domain: PKS_KR (9-172). E-value: 1.5e-15. Score:
                     49.5. Matches aSDomain:
                     nrpspksdomains_EBH12_RS24560_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446456.1"
                     /locus_tag="EBH12_RS24560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_114872848.1"
                     /sec_met_domain="adh_short (E-value: 8.6e-30, bitscore:
                     102.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGPLGGRTAVVTGAARGIGAGLARELAARGMRVALLGHEGDRL
                     RRLADDLPAPALAYEVDVTDDAALEQAADAVRTGLGTPSVVVANAAVADAGLFADSDPA
                     RWGRIVDVNLTGSANTARTFLPDLTATKGHYLQVASLAAIGAAPMMSAYCASKAGAEAF
                     AHSLRAEVAHLGVTVGLGYLTWIRTDLIDDADRHGVMQELRGHMPWPVRDVYPPDRAAA
                     RLAQAVERRSTAVYYPRWLRLAQPVRAALPAVVTRATRHYLPRIEARSSLAHTDLLGGG
                     GTADAKAARPS"
     aSDomain        complement(15298..15786)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS24560_PKS_KR.1"
                     /evalue="1.50E-15"
                     /label="EBH12_RS24560_PKS_KR.1"
                     /locus_tag="EBH12_RS24560"
                     /protein_end="172"
                     /protein_start="9"
                     /score="49.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAARGIGAGLARELAARGMRVALLGHEGDRLRRLADDLPA
                     PALAYEVDVTDDAALEQAADAVRTGLGTPSVVVANAAVADAGLFADSDPARWGRIVDVN
                     LTGSANTARTFLPDLTATKGHYLQVASLAAIGAAPMMSAYCASKAGAEAFAHSLRAEVA
                     "
     CDS_motif       complement(15697..15780)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EBH12_RS24560_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="EBH12_RS24560"
                     /protein_end="39"
                     /protein_start="11"
                     /score="14.1"
                     /tool="antismash"
                     /translation="VVTGAARGIGAGLARELAARGMRVALLG"
     gene            complement(15810..16295)
                     /locus_tag="EBH12_RS24565"
     CDS             complement(15810..16295)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525631.1"
                     /locus_tag="EBH12_RS24565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_114872849.1"
                     /transl_table=11
                     /translation="MSGRNGRPDDSPDRRHQRPEGLSDETVEALGSLSKALETTERARG
                     HLYSFHQLTGTADLELDRAVELLHKAGHPDWAEAVRTQVLGRNVIPGHWTFQIVEAYDH
                     TYYRPFRELEQAAVEELADGRDHLFEAEMKEARRTAGHPHHTARPDVDPQITGGDGG"
     gene            complement(16354..17997)
                     /locus_tag="EBH12_RS24570"
     CDS             complement(16354..17997)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525630.1"
                     /locus_tag="EBH12_RS24570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_114872850.1"
                     /sec_met_domain="DAO (E-value: 2.7e-07, bitscore: 29.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADAVVIGAGPNGLVAANLLADAGWSVTVLEEQPEPGGAVRHDHG
                     VHPDFANDLFSSFYPLAAASPVVSGLGLEEHGLRWSHAPHVVAHPLSDGRCAILDRDVD
                     VTADSLDTFAPGDGDAWRRLHSMWDTLRPDLLDALFTPFPPVRSGLRLAVRLRGTGGLR
                     MARTLVLPVRRMAEEEFRGEGGGLLLAGNALHADLAPEAAGSGGFGWLMSMLGQTYGFP
                     VPVGGAGALTDALVRRLESRGGALRCGRHVERVVVRDGRAVAVRLADGETVPARRAVLA
                     DVSVPALYGELVAPEDLPRQLLSDLERFQWDFATFKVDWALDGPVPWQCEQAAGAGTVH
                     LADGLDELTRFAAQLAMGRVPDRPFSLFGQMTTSDPTRSPAGTESAWAYTHVPHRVVGD
                     AGDDGITGSWDKDEQDRMADRVEAHVERFAPGFRDRVRARRILAPPTLQNLDRNLHGGA
                     INGGTAAMHQQLFFRPAPGTGRSETPVKGLYLASAGAHPGGGVHGAPGANAARAALRPS
                     FAPGLAAAQRLLAHRDRTGHRQPDRGGRPA"
     gene            complement(17990..18496)
                     /locus_tag="EBH12_RS24575"
     CDS             complement(17990..18496)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-141). E-value:
                     3.3e-09. Score: 29.2. Matches aSDomain:
                     nrpspksdomains_EBH12_RS24575_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827623.1"
                     /locus_tag="EBH12_RS24575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SRPBCC family protein"
                     /protein_id="WP_048458303.1"
                     /transl_table=11
                     /translation="MAVRHRLIRTDPRTVWSVLEDGTRYADWVVGTSESKPVRGHWPQL
                     GSAIRYEVPVGPLKLHNETVVRRCVPGEVLELEANAGPLGTARIAIEVQPWGDWCLVKV
                     DEHPLRGAGGFLHNVGVEALIQIRHRAMLARLAHLVETEAAETEERRPLGQIVPPEPDA
                     GGARG"
     aSDomain        complement(18074..18487)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS24575_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.30E-09"
                     /label="EBH12_RS24575_Polyketide_cyc2.1"
                     /locus_tag="EBH12_RS24575"
                     /protein_end="141"
                     /protein_start="3"
                     /score="29.2"
                     /tool="antismash"
                     /translation="RHRLIRTDPRTVWSVLEDGTRYADWVVGTSESKPVRGHWPQLGSA
                     IRYEVPVGPLKLHNETVVRRCVPGEVLELEANAGPLGTARIAIEVQPWGDWCLVKVDEH
                     PLRGAGGFLHNVGVEALIQIRHRAMLARLAHLVE"
     misc_feature    18465..18478
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(18583..>18753)
                     /locus_tag="EBH12_RS24580"
                     /pseudo=""
     CDS             complement(18583..>18753)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135553.1"
                     /locus_tag="EBH12_RS24580"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF2236 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LPSGVLAANALPRLPPWASRELRVPRLPAEGLCVRPLGTAVTAGI
                     RWALAPTRPAA"
     gene            18978..20962
                     /locus_tag="EBH12_RS24585"
                     /pseudo=""
     CDS             18978..20962
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488081.1"
                     /locus_tag="EBH12_RS24585"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DEAD/DEAH box helicase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MERLLPVPTALDLTDGELRDLLGGAAGRLAGHGIDVTWPKTSTGA
                     LTARAVAGADRMPPADLRSFFGGDGTVDLRWRLELDGDPLTDDEAATVADGGAVARLRG
                     RWILVDAGIARKARDRRLPPLTAIEALAVALTGHTDIGGERVRVAPSAWLDALRRALAD
                     PDGGDGAVDQPARLTATLRDYQLRGLRWMDRMTSLGLGGCLADDMGLGKTIQLISLHLL
                     RQERPEDRGPTLVVCPASLLGNWEREVGRFAPGTPVRRHHGPGRTLDGADEGFVLTTYG
                     TMRLDAARLGAHTWGLVVADEAQHVKNPHSSTAKALRQIGARARIALTGTPVENNLSEL
                     WAVLDWTTPGLLGTHRRFRTRWIARVEAERVLAANGDGEQHTARLLSELVRPFLLRRRK
                     TDPGIAPELPPKTETDRPVALTAEQDTLYRKQVETVMGEIRAGAARSAPARAASPAAAW
                     C"
     gene            20959..21744
                     /locus_tag="EBH12_RS24590"
     CDS             20959..21744
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="EBH12_RS24590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_196421329.1"
                     /transl_table=11
                     /translation="MSEAQRSGARGFPAFAARRGGRARGQSFWAAQWAGAVEDVWPEEG
                     PLKKGRSFARTGRIGPITVSPGRVAAEMYGGEETCTTRLTLTVLDDDAWDLLWEKTADR
                     PAEAEALLAGDLPEDLLEAVEDARVNMLPGYGDLDADCDCDGLDHPCPHATALAYQLSW
                     LLDADPWLLLLIRGRAAGEAVEELKSALLLRALAGGEEENDLTSRRVGRARRLLLEGWP
                     PSDVAAAAGFYDQAHLTRHFRRLVGVTPGRYRATDAAGA"
     gene            complement(21701..22222)
                     /locus_tag="EBH12_RS24595"
     CDS             complement(21701..22222)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133925.1"
                     /locus_tag="EBH12_RS24595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbjN domain-containing protein"
                     /protein_id="WP_048458991.1"
                     /transl_table=11
                     /translation="MADTEAEQRAARIVEGVLKDAELEWESPAPGNYVVKLPGTRKLST
                     TVSLIVGRHTLSLNAFVIRHPDENETGVHRWLLERNLKLFGVSYAVDPLGDIYVTGRLP
                     LPAITPEELDRLLGQVLEAADGSFNTLLELGFASAIRKEYAWRVSRGESTRNLDAFTHL
                     LRPSPGSVPE"
ORIGIN
        1 cccccacctt accgcagctc ggtacgctct tgtcagcagt accggcctgc ctcgcaccaa
       61 ggagcccacg ttgagcgccc ccgagtcgcc ccagcccgca gacgtgcccg acgacgacaa
      121 gtcgcacgtg ccgccgatga cgacccgcgt cgtcatcgcc gaggacgagg cactgatccg
      181 gctcgatctc aaagagatgc tcgaggagga ggggtacacg gtcgtcggcg aggccggcga
      241 cggtgagcag gccgtcgagc tggcgcgcga gcaccgcccc gacctggtga tcctcgacgt
      301 gaagatgccc aagctggacg gcatctccgc ggccgagaag atcgccgagg agtccatcgc
      361 ccccgtgctg atgctgaccg ccttctcgca gcgcgacctg gtcgagcggg cgcgggacgc
      421 gggcgcgatg gcgtatctgg tcaagccgtt cagcaagagc gacgtggtgc ccgcgatcga
      481 gatggcggtc tcccggttca cggagctgaa ggagctggag cgcgaggtcg ccgacctcag
      541 ccagcgcctg gagacgcgca agctggtgga ccgcgccaag tcggtgctcc agacgcagta
      601 cggcctgagc gagccggccg cgttccgctg gatccagaag acctcgatgg accggcgcat
      661 gtcgatgcag caggtcgcgc aggcggtcat cgacgacgcc gaggagaaga aggccgcgaa
      721 gggcggctga cctgccgtca cacggacgcc gaaggcccgc accccgtgaa ggggcgcggg
      781 ccttccgcct gccgggtcag tcctcgccga ggtaggcctt gcggaccgac tcgtcgtgga
      841 gcaggtcgcg gccggtgccg gagaggacga tgttgccgac ctccatcaca tggccgtggt
      901 cggccaggga cagggccgcc tgggcgttct gctcgacgag caggatggtg gtgccctgcg
      961 acttcagctc ggcgatggtc gccatgatct tctgcatcat gatcggcgac agacccatgg
     1021 agggctcgtc gagcatgagc agctgcggac gggacatcag ggccctgccc atggcgagca
     1081 tctgctgctc accgccggac agggtgccgg cggcctgctt gcggcgttcc ccgaggatgg
     1141 ggaagaggtc gtaggcgcgc cggatgtcct gctcgatgcc ctgcttgtcg ctgcgcagga
     1201 aggcgccgag gcgcaggttg tcctcgatcg tcatgcgcgg gaagatgtgc cgcccctcgg
     1261 gggagtgggc aagacccagc gagacgatct tgtgggcggg gaccctcttg agcgatctgc
     1321 cgttgaactt gatctggccg ccgaccggct tcagcagccc ggacagcgtg cgcagggtgg
     1381 tggtcttgcc ggcgccgttg gtgccgatca gggtgaccac ttcgccggcc tcgacgctga
     1441 acgagatgcc cttgacggcc tggatcttgc cgtaggcgac tttcaggtcc tcgacctcga
     1501 gcagtgcggt catcggtcgt tctccttgcc gggcgcggtg tccgtggtgg cctcggcctc
     1561 cgcctccgcc tgtgcttctg tctcggcgtc cgtcgtctcg gcgtccgtgg cttcggcgtc
     1621 ggcggagtgg ccggcctcgg cggccgcttc cggccgcggg tccgcctcgg ccgtctcctc
     1681 ggccgcctcg cccgcgggcg ccggggcgcc ggccgtcttg gcggacgact ggggccggcc
     1741 cgccgcctcg gccgccgctt ccgcggcctc gacctcggcg acctcggcgg cgccggggtc
     1801 gtccgccagc ggctcgccga tgtacgcggc gatgacccgc tcgtcgccct ggacggtggc
     1861 cgggtcgccc tcgatcagct tctggccctg cacgagaacg gcgacccggt cgcagaggtt
     1921 gaagatgaac cgcatgtcgt gctcgatgac gaggaccgcg gtgccctggt cgcggatggc
     1981 gaagatgagt tcctcggccg cccgggtctc ctgggggttc atgcccgcgg tgggctcgtc
     2041 gaggagcagc agccccggct cgctggcgag cgcgcgggcg atctccagct tgcgctgctc
     2101 gccgtagggg aggttgcgcg cgagctggtc ggccttctcg gcgaggccta cgaactccag
     2161 cagctccagg gcgcgggcgc gggaggcggc ctctgccttg tggaagccgg gcccgcgcag
     2221 gacggccgac cagaagccct ccttggtgcg ggtgtggcgg ccgacgagca cgttctccag
     2281 gactgtcatg ttggcgaaca gacggatgtt ctggaacgtg cgggcgatgc cggcggcggt
     2341 cactttgaag gacttgggcg gcagcacctt gtcctggtag cggacctcgc cctcggtcgg
     2401 gatgtacagc ccggtcaggc agttgaagaa cgtggtcttg ccggcgccgt tggggccgat
     2461 cagaccgacg atctcgccgc tgcggacggt gaggtcgacg tccttgacgg cggtgaggcc
     2521 gccgaaccgc atggtgacgc cgcgcgcgtc gaggacgacg gagccggggg cgggcgggcc
     2581 cgcggcgctg tccttggtga tggtgtcggt ggtcatggtg gtcaggcccc cgtcttgctc
     2641 aggactgtgg gcgcgtcggc ctcttcgtgg aactccagct ggcggcgccg gttggggatg
     2701 aggccctcgg ggcggaagcg catcagcagc acgagcgcga gaccgaacgc gaggagctgg
     2761 tagtcgccca ggaactggag cttgttgggg atcaggaaga gcagcgccgc accgatgagg
     2821 ggtccggcga tggtgcccat tccgccgagc acgaccgcgg ccagcaggaa ggcggagttg
     2881 ggcggggtgg tgccggcgaa caggtactgc tcgggggtca cggtgtacgt gacgtgcgcc
     2941 tggaccgtgc cggccagacc ggcgagggtg gcgcccacgg cgaaggcgac gagcttcacc
     3001 cggaagccgt tgatgcccat ggcgagcgcg gcggtctcgt cctcgcggat ggcgacccag
     3061 gcgcggccga tgcgggagtc gccgctgcgc cggaagacga ggacgacgac ggccgtgatg
     3121 agcagcatca ggaagaagta gttcgcgaac cggccgatgg tgaagccgcc gatgtcgtgt
     3181 gcgacgccca ggtcgaagcc caggatgttc aggtctggga tggacgcgat gccgttggag
     3241 ccgttggtga tgtccggacc cgaggtgccg tcggtgttgt tcacggcgat acggaagatc
     3301 tcaccgaagc cgagggtcac gatggccagg tagtcgccgc ggagccggag cgtcggtgcg
     3361 ccgatcagca caccgaagac cagtgaggcg atcgcgccca ccaggacggc ggcccagaag
     3421 gggaagtgca cgccgaacgg cgagctgggc gagccggaga ccagcgcggc cgcgtaggcg
     3481 ccgacgccga ggaaggcgac gtagccgagg tcgagcaggc cggcgaggcc gacgacgatg
     3541 ttcaggccca gggcgacggt ggcgaagatc aggatgtaga cgccgagggt ggcgtactgg
     3601 tcgtcggtct gggtgaaggg gaacagcgcc gcggcgatga acgcgccgca gacggtgatg
     3661 ttctggtggc gggcgctgat ctgggaggcg tgggcgatca ggccggagcg gttcagcgcg
     3721 ccgaacccga agccggcggt gatcaggaag ccgacgaaca gctcgtcgta ctcggtgccg
     3781 atgccgtagg tgaagacgat cagggcgacc gccaggacgg cgacgatgat caggatttcg
     3841 gcgtacgacg gcagcgtgcg cacggggcgc ggggagccgg aggcgaaggc cgcgcgcagc
     3901 acggccatgg tgtgcgcggc gtcgtgcgtg aactgctccc agccgttcgc ctcggggtcg
     3961 atcgggtcgg gctcgggccg ctcgaagggg agggccaggg cgccgatcag ggctgtgagc
     4021 gtggcggcgg cgacgacgta gccgcccggt tccaggttga cgactccgcc gagctcgacg
     4081 ctgatcgaga cgacggtgta ccaggcggtg gcgaaggtgc cgagcaccgc gtacttcacg
     4141 gccgcgtcgg cgccggcggg ggtgacgggg tggccgggcg ccagggcgga ggccaccagt
     4201 ggatgcagcc gtccggcgtc gatcgcgccg gcctggagca gggcgaggtc gggaaggacg
     4261 tgggtcgccg cgtccggcag gaggggcgtc gtcctgaagg cggcgggttc ggtggacacc
     4321 gcgaccggac ggcatccgtc gcgggtcagg tccagcacca gccggcgccg ggcgtccagc
     4381 cgcacgacga cgggccctcc cgtgcgttcc cgtcccgcgt cacggagcag gacgcgggcc
     4441 tcgtccgccc agcggcccac ggcgtagtgg tggcccggcg gcagcagccc ggacggcacc
     4501 acggcctccg tccggggcgc aaccgttccg gaccggtgcg gcagttcggg cgtccggcgg
     4561 gcgtcccaca ggtgccggtg caggtcgaac cggaaccgct ggccgggccg ggggcgcgga
     4621 tgcccgcggg ccccctcccg caaccggtcg ccgtcccaca gcgcgaggct catgcgctgg
     4681 ccgcccgccg cccacgcggg cggggtgcgg accaccaagt acacggggcg gggcccgtcc
     4741 ggttcgtcca cggtgtagcg ggcgaggggg acggtgaggc ccggccgcag caggccgtcg
     4801 ggggcggccc tcggcatgtg ccagcgcagc aggtcgggcg ccaaggaccg caggtccgcg
     4861 cgtacttgtg ccgtgaggcc gacgccgtgg gtgcgggtga ggccgcgcag ccgcaggtcg
     4921 acgtcgacgc gggccgcggc gcacgccccg gcccagtcgc cggagcggcg gcgggcggtc
     4981 gcggtctcga tcatggtggg cggcacggcg tactcgcgta cgcgccgcca gagggagaga
     5041 cgggagtcct cgtccacggg gcgtgggtgc atcagcactc accttgcgtg gacgggacct
     5101 cccttctgtg aaggaaggag gtggtcatcg ccgtcaggtt agtgcgccgt ggatcaccct
     5161 gtcaggtggt ttttccggaa cggggctgcc atgtcgtcgg gaacgtgcgg tagttgcggt
     5221 gtgagccgac cactcgtacg ggaatcaatt gtcatgaacc tgcggcccga tggtcgggcc
     5281 gcagtctcat ggaggtgtgg gatgcaccga agactcgccg ccgcactcgc caccccggcc
     5341 ctcgccctcg tgggcgtcct cggcacggcc accgccgcgg acgcggctcc cgccgacaag
     5401 ccacaggtcc tggccggctg gacccagacc agcgcatcga gctacagcca gtgggccgcc
     5461 gcacgctcca accagggcgc ctggtccgcc tacgggttcg actggtccac cgactactgc
     5521 tcctcctctc ccgacaaccc cttcggcttc ccgttctcca gcgcctgcgc ccggcacgac
     5581 ttcggctacc gcaactacaa ggccgccggt tccttcagcg ccaacaagtc ccggctcgac
     5641 agcgccttcc acgaggacct caagcgcgtg tgcaacggct acggcggcgc caccaagtcc
     5701 gcctgcaaca gcaccgcctg gacctactac caggccgtca aggccttcgg ctgaccctcg
     5761 tccaccgagc agacaccgag agagcaccgc gggacaccgc gggcctcgca gccgggtgac
     5821 agctccccgc cgcgaggccc gtggtgacct tccgcgtccg tcaacggcgg gcgcgcacca
     5881 gcacgtagag gaagtacggc gtgccgatga ccgcagtcat caggccggcg cccagctgcg
     5941 ccggggcgat gacggtgcgg cccagcaggt ccgccgtgca cacgagcacg gcgcccagca
     6001 gcaccgcgac cggcagcacc cgggtgtgcc ggcggccgac cagggcccgc gccgcgtgcg
     6061 gagccaccag gccgacgaag ccgatggtgc ccgcggcggc cacggcggtc gccgtcagca
     6121 gcacgctcag cacgaggaag ccgagccggc cccgcgcgag gtccaggccg aggagtctcg
     6181 gtgtgtcctc gtccagggag accaggtcga gctcccggtg ccgtacgccc gccgccgcca
     6241 cgccgaccgc gagcaccgcc gcgaggggca gcacgtcggg caggtcacgg ccgtaggtgg
     6301 agcccgacag ccaggtgagc gccttggtgg cgttgaacgg gtcggtgagc acgatcagca
     6361 ggctgatcac tgcggtcgtc ccggacgcca ccccgatgcc gacgagcacc agccggttct
     6421 gctggaagcc tccgcgtgcc gcgagcccga acacgaggac cgcggtgagc gcggaccccg
     6481 cgaaggcggc ggccgagacg ctccatcccc cggccatcgg gacggtggtc accaggacga
     6541 cggcaccgag cgcgccgcct ccggaaacgc cgaggacggc gggttccgcg agcgggttgc
     6601 gggtgacggc ctggacgagc gtgccggcca gcgcgagggc ggcgccggcg aggagcgcgg
     6661 cgagcacccg cggggtgcgc gtgtccagga cgaaggagac cgtccggccc gcgttgccct
     6721 gcgcccagtg ggccacgtcg cccagcagca gtttgtggtc gcccagcagc agccccgcga
     6781 cggcgacgcc ggcgagcgcg aacaccagcg ccgtgagcgt gaggacgaag accctacggc
     6841 tgcggatgct gagcctgtcg gatgcggctg tgccgcccgt gtcgcgcagc cgggccgcca
     6901 tcaccaccag gaacgccgcc cccacgaagc tggtgaccac accggtgggc accgcgacgg
     6961 cggtgtcggc gtcgatcatg gcgcgcagca gcacgtccgc gccgagcacc agcgcggcac
     7021 cgacgagacc ggtgaccgcg gcgccggcgc gcaggcgccg aacgccgcgg acccagcggg
     7081 cgagcgggcg ggcgagcgcc ggggcgcaca ggccgacgaa gccgatcggt cccgcgaggg
     7141 tgacggccgc ggcggacagc agcgtcgcca gcacgacggc cgtgacgcgg gtggcccgca
     7201 ccggcacgcc gaggccgcgc gcggtgtcgt cgccgagcgc gagggcgtcc acccggcgcg
     7261 cgacgaggaa cagcccggcg agcccgatga cgacgacggg cagcatctgc agcacgccgt
     7321 cgaagccgtt ctggccgatg ctgccctgat tccactggta gaggccctcg gtctcctccg
     7381 ggaacagcag gagcagccct tcggtgacgg cggtcaggcc gagcgcgagc gcggtgccgg
     7441 ccagcacgag ccgtacggtg cccgcgccga gcccggacag gccgaggacg acggccgccg
     7501 cgcccagacc gcccgcgaag gcgacggccg aggaggcgat cagcggcagc gacaggccgg
     7561 tgacggcgac gacgccgagg gcgaagtagg agcccgcgtt gacggcgagg gtgtccgggg
     7621 acgccaggac gttgcggctg acggcctgga gggcgaggcc cgcgacgccc agggcggcgc
     7681 ccacgagcag ccccgccgcc atccggggca gccgcgaggc gatgacgacg gacgcgtcgc
     7741 ccgggtcggc ccggccggtg agggccttga ggacctcggc cgggccgacc gcggccgtgc
     7801 cctgcgtgac gtcgacgacg gcgagggcgg cgaccaggag cacgagcgcg gtcgtcaccg
     7861 cggccgcgcc cgcccgggac ggaaccgtct ccgggcggac ggtgggaggg gtggcggtga
     7921 cggccatgag ctacttcgtc agcgccgcga cgagggcgtc gacgtaacgc tccatcgagc
     7981 cggtgccgcc gaacatccat atgccgtcgt cgaggcggtg cacgtcgccg gacttcacga
     8041 acggcagcga cttccacacg gcgttgttct tcagttcgtt gccgaacggg tcgctggcgg
     8101 cgtcctgctc gttgccgatg taggcgaact gcaccgcgcc cagggcggtc aggccctcga
     8161 cgtcggtggc ggcgaggccg tacgcctcgt cgcccttgag cttccacgcg ttcttcaggc
     8221 cgagccgctc gttgacgccg ccgatgagcg agccggaggt gtaagggcgc agggagacct
     8281 ggttggagac gacgtagccg tcggagaagg cgatctcggc gcccttcagg ccggcgtcct
     8341 cgagggcctt ggcgccctcg gcgagcttgg cgtcgaagtc cttcttcagg gtggcggcct
     8401 gctcggtggt gccggtggcc ttggcgatga ggtcgaggtt ctccagcatc tgcccgaccg
     8461 ggtcggaggc gtcggcggac ttcacctcga ggaccggggc gatcttgcgc agctgcttga
     8521 ccgcgttcgg ctggaggtcg gtggtggcga cgatgaggtc ggggttcagc gcggcgatgg
     8581 tgtccgtgct gggctcgccg cgggtgccga tgtccttggc gtcgttggtg agcggtacgg
     8641 cgctgtccca ggtcttgtag cccttgacgt cggccacgcc gacgggctcc actccgagcg
     8701 agaggaggtg ctcgacgacg ttccactccg tgccgacgac cttcttggcc gggccgtcga
     8761 gctccacctt ggcgccggac gcgtcggtga gggtgatggg ctcggccgac gccttgggcg
     8821 cctcgtcggc cgcgggttcg gtggtgccgc aggcggcgag cagcagggca gcggcggcgg
     8881 ccaggggcgc ggtgcgcagg aggcgtctca tgaggtggtg ctgagccttt cgcttcgggt
     8941 gtggtgacgg ccgagggcgc gggtgcgcag gcggccggtg agggggtcgg tgtcgacctc
     9001 gatgcggatg ccgtagacgg cggtgagccg ctcgggggtg aggacggctt cgggtgctcc
     9061 ctcggcgacg acgcgtccgt ccgccaggag cacgatgcgg tcggcgacgg cggccgcctg
     9121 gtcgaggtcg tgcagcacga ccccgacggc gatgccctgg tcgtccgcca ggtcgcgtat
     9181 caggtcgagg agctcgactt gatagcgcag gtcgaggtag gtggtgggct cgtcgaggag
     9241 cagcacgccg gtctcctggg cgagacagcc ggccagccag acgcgctgga gctgtccgcc
     9301 ggagaggtgt tcggcgccgc ggtcggcgag gtcggtgacg ccggtgaggg cgagggcgcg
     9361 gtcgacggcg gcccggccgc ccgggtcggt gccgccccag cggccgcggt gcgggtagcg
     9421 gccgaactcc acgacgtcgc gcacgctgag cccgctgggg gtgggccggc tctgcagcag
     9481 cagcgcgacg tggcgggcga actcccgggg gccgagcgcg agcgcgtcgg tggcggcgtc
     9541 gagcgtgagc acggcgtgcc gggggcgctg gagccgggcg acggtgcgca gcagggtcga
     9601 cttgccgctg ccgttggggc cgacgagcgc ggtcacctcg ccggggcgca gtgtcagctc
     9661 cgcggcgtgc acgacgtccg tgccgtcgta cgccacggtc acgccggtgg ccgccagttc
     9721 atgccctcgc aggcccgagg acgcgtcttc acctggaatc acgcggcaag gttagcctac
     9781 ccttaattcg ggtgacaggg gggtggcccg cgggagcccg aaggcgcggg gcgcgtccgg
     9841 gctcgcgggg tgtcagaacg cgtagcgcac gcccagccag ggggtgcggc gctcgatgag
     9901 ctcgcggagt cccgcgaggg cctggcgttt gacgcccgcg tggtagcgga ggttgagggc
     9961 gccgttctgg gagcgcttcg tctcctgcag cccgggctgc ggacaggccg tcggcgggct
    10021 gcggggtgcg gaagtccatg agttcggcgg tgtggggggc gaaggcgggc cgggcggtgc
    10081 gcacgaacca gccgtggaag tgctggagca gcgtggtgcg ggcggcgggc aggctgccgg
    10141 gcgggcgtga gtcgaacacc cagcgggcgc ccacgacgcg gggggcgccg tcgcggtcgc
    10201 gcagccgcac cagcgctccc ccgggcacgt cctccacggt gtcgacggtt ccctcgacac
    10261 gccgtacccc gtcgtgtccg gccaggtcgc gggcgacgag gtgctcgaag tcgtcggagc
    10321 ggatcatctt gtagcgcaga ggggcgatgt ccccgtcgat gaggcggcct ccccggtcgc
    10381 ggacgcgcag gctccgccag gacgcggtga cggcggcgtc gaagcggccg gggcccgcct
    10441 cccagaagca ccaggtgcgt cgcggcggtc gcagcggtcc gggcggcgcg tccagcaggg
    10501 ccacggacgg cgcccggcgc ccgctgccgg gaccggccag ccggtgggcg agggacagcc
    10561 cggccgcccc cggtacgacg ccgtgcggat ccgcacggcc ggttgtttcc gtccgtgtgc
    10621 ccgcgcggat ccgggtcact cggacgtgag acgacgggcg cgaccgggaa ggcatgcgcc
    10681 ggtcgtccgg cgtaccggaa cgatgcgcgt gccgacgaga ggaagacacc ggatgctccc
    10741 cactggggcc aagagacacc gcgcgacgat gccgtcgcgc gcgccgcgcc cggcccgtcc
    10801 gcccggaccc accgtccggg tgcggtccgt ccgggtgccg tccgtgagcg tgacggcgga
    10861 caccgtgtgc gggtgcgcgg caggagcggg ggccgggcgg tgacccgtac cgttccgggg
    10921 cgcacggacc atgtcgtcgt cgtgggagcc ggcctcgccg gtctgtcggc ggcgctgcac
    10981 ctgctgggcg cgggccggcg cgtcaccgtc gtcgagcggg acggactgcc gggcgggcgc
    11041 gccgggcggc tggagctgga cgggtaccgg atcgacaccg ggcccaccgt gctgaccatg
    11101 cccggcctgg cggacgagcc gttcgccgcg gtcggcgaca gtctgcgcaa gcgggtggag
    11161 ctggtaccgc tgcaccccgc ctaccgggcg cggttcgccg acggcagcag cctcgacgtg
    11221 cacacccggg cggagccgat ggccgccgag gtggagcggt tcgccggggc aagggaggcg
    11281 gcgggctacc tgcggatgcg ggagtggctg gaacggctgt accgggcaca gatgcgccgg
    11341 ttcatcgacg cgaacttcga ctcgccgctc ggcctgctcc atcccgacct ggcgcggctg
    11401 gcggcgctgg gcggcttcgg gcggttggac gcccgcatcg ggagcttcct gaaggacgag
    11461 cggctgcgcc gggtgttctc cttccaggcg ctgtacgcgg gcgtgccgcc ggcgcgggcg
    11521 ctggccgcgt acgcggtgat cgcctacatg gacaccgtcg ccggggtgta cttcccgcgc
    11581 ggcgggatgc acgcgttgcc gcaggcgatg gcggacgccg ccgccgacgc gggcgcggac
    11641 ctgcgcttcg gtcgggaggt gacccggctg gagcgttccg gcggccgggt gacggcggtg
    11701 gtcgcgggcg aggagcggat cccctgcgac gcggtcgtcc tcacgcccga cctccccgtc
    11761 acgtaccgtc tgctgggcgg ggcgccccgc cgtccggtgc ggctgaggca ctcgccgtcg
    11821 gcggtggtgc tgcatctggg caccgaccgg acctggcccg aactggcgca ccacacgatc
    11881 tccttcggtg aggcgtggcg cgggacgttc gacgagctga cccgggccgg gcggctgatg
    11941 agcgacccgt cgctgctgat cacccggccc accgccaccg acccgtcgct cgcgccgccg
    12001 ggccgccatc tgcactacgt cctcgcgccc tgcccgaaca ccgacatcgg gccgggcgcc
    12061 gccgagtgga cggacctggc gccgcgctac cgggacacgg tgctgcggac gctggagggg
    12121 cgcggtctga ccgggctggc ctccgcgatc gagacggaat gcgtggtcac gcccgccgac
    12181 tggaccgcgc aggggcacgc ggccggtacg ccgttcgcca ccgcccacac ctttgcccag
    12241 acgggcccgt tccggccccg caacctggtg cgctccgccg agaacgcggt gctggccggc
    12301 tgcggcacca cccccggcgt cggcgtgccg accgtgctgc tgtccgggaa gctggcagcg
    12361 gcgcgcatca ccggcgccga cggccccgtc ggacgcgcgt ccacctcgtc ttccgcccag
    12421 gaggccctgc atgaccgagc gtgaactgga cgcggcgggg atcaccgatc cggtgctccg
    12481 cgaggcgtac gaccactgcc ggcggctcaa cgcccggcac ggccggacgt acttcctcgc
    12541 cacccggctg ctgcccgtgg agcggcggcc cgccgtgcac gcgctgtacg gcttcgcccg
    12601 ctgggcggac gacatcgtcg acgcgctcgg caccggcgcg gacaccggcc gccgggacgc
    12661 cgaactggcg gcgctggaac gggagctggc caaggggctg cgggacggga agagcgccga
    12721 gccggtggtg cgggcgctcg ccgacacggc ccggcggtac ggcatcgacc acgcccactt
    12781 cgccgacttc atgaccgcca tgcggtccga cctggtggtc accgactacg ccgactacgc
    12841 ggccctgcgg aggtacatgc acgggtcggc ggcggtgatc gggctgcaga tgctgcccgt
    12901 cctcggcacg gtcaccgacc gcgacacggc cgccccgcac gcggcggccc tcggcgtcgc
    12961 cttccagctg accaacttcc tgcgggacgt gggagaggac ctggaccggg ggcgggtgta
    13021 cctgccggcc gatctgctcg ccgcgcacgg tgtcgaccgg gagcggctgc ggtggagccg
    13081 ggacaccggc cgccgtgacc cgcgcatcac ctcggcgctg cgcgcgttcg agcggctgac
    13141 gcggggcgtg taccggcagg cggccccggg cctcgcgatg ctcgaaccgg tgtcccgccc
    13201 ctgcatccgc accgctttcg tgctgtacgg cgggatcctg gacgcggtcg ccgaggacgg
    13261 gtacgcggtg ctgcaccggc ggtcggtggt gccgcgcagg cggcgcgccg tggtggccgc
    13321 ggacgggctg gcccgggtgg ccgcggcgcg gctgcgggcc cggtcggccg cccgcggaac
    13381 cgaacgggct ccgctgacgg cgccggagcc gcggatggtc gaggaggtcg cgtgatggcg
    13441 ggtgacggac gacggcggcg gctgccgctc tccctgcgcc gcaacgcggt ggcgtgggaa
    13501 cggcagcgcc ccacctggcg ggacgccaag cccgccctga tcgccggcgc gttgaaacgg
    13561 gcgcaggccc gcccgtcggg caactggtac gtcgtggggt cctcccgcga cgtcggcggc
    13621 gaccgtccgc tgggccggac ggtcgcggga caggaagtgg tggtctggcg cgacacgggc
    13681 ggccgcgtcg tcgccgggcc gggcgtgtgc ccgcatctgg gcgcgccgct gcgggacagc
    13741 ccggtgcgct gcggcacgct cgtctgccac tggcacggac tgtccctgga cggcgggccg
    13801 ttcgccggct gggagccgtt ccccgcctac gacgacgggg tgctggtgtg ggtacggctg
    13861 gacgcggtgg gcggcgagga gccgctcgac gcgccggtgg tgccgagccg cccggtgccg
    13921 gcgcgcgccc tgacggcggt gtacgcgggc gtgggcgtct gcgagccgga ggacgtcgtg
    13981 gcgaaccggc tcgacccctg gcacggggcc tggttccacc cgtactcgtt cgtcgacctc
    14041 acggtggcgg acacgcccga gagcgcgggc gaggacgcgt tcgccgtgga cgtgtcgttc
    14101 aaggtggcgg gccgcctggt ggtaccggtc cgggcggtct tcacggctcc ggagccgcgc
    14161 acggtcgtca tgcacatcac ggagggcgag ggggtcggct ccgtggtcga gacgcacgcc
    14221 actcccctgg gtccggacgt ctccggccgg ccgcgcacgg cggtggtcga ggcggtggtc
    14281 gcggcctcgg accgccgcgg cttcgccctg gcccgagccg cggcacccgt cctgcgcccc
    14341 ctggtccgcg ccgcctccgg ccgcctctgg cgtgacgacc tggcctacgc ggaacgccgc
    14401 tgggcgctcc gctcgacggg acggttcccg ggggcgtgac cgtccggccc gcccggtggg
    14461 gacaccgtcc gggccggacg acggcggctt caccgtgatg gcgagcggag ccctggtccg
    14521 gctgacggcg ccgggccagg gccccgagga ttccggtgca cagggtcgac gggcgaggga
    14581 gccacgccga agggagcgcc acgccggccg ggggacgtcc gcacttcggc ccgcgtcggc
    14641 accctgctgt gcatccgccc gacggcgggt cccggtccct tctcctccgg tcggcccgga
    14701 gcccactcgg cgctcgccgg cggaggggac gggtcgcgcg ggtggccgcg ggaccgtgcg
    14761 cctccgctgg gtcgggcagg cgcccacggt gtcccgcgcg accccggcgg gcggcgcgcc
    14821 ggcgcctcgc cccgcaccca gggcgcccac ggcgcggtac ggaccctgtc cacggggcca
    14881 cccgccgcgc acgtcagagc cgtaccggac cgggcggcgc gccgagaccg cgtctcagct
    14941 cggcctcgcc gccttcgcgt ccgccgtgcc gcctccgccc aggaggtccg tgtgggccag
    15001 ggaggaacgc gcctcgatgc gggggaggta gtggcgggtc gccctggtga ccacggccgg
    15061 cagggcggcc cgtaccggct gggcgaggcg gagccagcgg gggtagtaga ccgccgtgct
    15121 gcggcgttcc accgcctggg cgaggcgggc cgccgcacgg tccggcgggt acacgtcccg
    15181 caccggccac ggcatgtgcc cgcgcagttc ctgcatcacg ccgtggcggt cggcgtcgtc
    15241 gatcaggtcg gtgcggatcc aggtgaggta gccgagaccg acggtcacgc cgaggtgcgc
    15301 gacctccgcg cgcagggagt gggcgaaggc ctccgcgccc gccttggagg cgcagtaggc
    15361 gctcatcatc ggggcggcgc cgatggccgc gagggaggcg acctggaggt aatggccctt
    15421 ggtcgccgtg aggtcgggca ggaaggtgcg ggcggtgttc gcgctgccgg tgaggttgac
    15481 gtcgacgatc cgcccccacc gcgccgggtc ggagtcggcg aacagccctg cgtccgccac
    15541 ggccgcgttg gcgacgacga cggacggtgt gccgagcccg gtccgtaccg cgtccgccgc
    15601 ctgctccagc gccgcgtcgt ccgtgacgtc gacctcgtac gcgagggcgg gggcgggcag
    15661 gtcgtcggcg agccgccgca gccggtcgcc ctcgtggccg agcagcgcca cccgcatgcc
    15721 gcgtgcggcg agttcgcggg cgaggcctgc gccgatgccg cgcgcggccc ccgtgaccac
    15781 ggcggtgcgt ccgcccagcg ggccgtcgct catcccccgt ccccgccggt gatctgcgga
    15841 tcgacgtccg ggcgggcggt gtggtgcggg tgacccgcgg tcctgcgggc ctccttcatc
    15901 tccgcctcga agagatggtc gcggccgtcg gccagctcct ccaccgcggc ctgctccagc
    15961 tcccggaacg gccggtagta cgtgtggtcg tacgcctcga cgatctggaa cgtccagtgg
    16021 ccggggatga cgttgcggcc cagcacctgg gtgcggacgg cctccgccca gtccgggtgt
    16081 ccggccttgt gcagcagttc cacggcccgg tcgagctcca ggtcggcggt gccggtgagc
    16141 tggtggaagc tgtagaggtg gccgcgggcc cgctcggtgg tctccagtgc cttcgacagc
    16201 gatcccagcg cctcgaccgt ctcgtcgctc aggccctccg ggcgctggtg ccgacggtcg
    16261 gggctgtcgt cgggccgtcc gttccgtccg ctcatcgtct cgcctccttc tggggtcggt
    16321 cgtccgtcgg gccgggggac ggccggacgg ggttcacgcc gggcgcccgc cccggtcggg
    16381 ctgccggtgt ccggtgcggt cgcggtgggc cagcagccgc tgggcggcgg ccagaccggg
    16441 cgcgaaggac gggcgcagcg cggcccgggc ggcgttggcg ccgggcgcgc cgtgcacgcc
    16501 gccgcccggg tgggcgccgg cggaggccag gtacaggccc ttgacggggg tctcggaacg
    16561 cccggtgccg ggggcgggcc ggaagaagag ctgctggtgc atggcggcgg tgccgccgtt
    16621 gatggcgccg ccgtgcaggt tgcggtcgag gttctggagc gtgggcgggg cgaggatccg
    16681 ccgggcccgg acgcggtcgc ggaagccggg cgcgaagcgc tccacatggg cctcgacgcg
    16741 gtcggccatg cggtcctgct cgtccttgtc ccaggagccg gtgatcccgt cgtcgcccgc
    16801 gtccccgacg acccggtgcg ggacatgggt ataggcccag gcggactcgg tccctgccgg
    16861 ggagcgggtc gggtcggagg tggtcatctg cccgaacagg gagaacgggc ggtcgggcac
    16921 ccggcccatg gcgagctggg cggcgaagcg ggtgagttcg tcgagcccgt cggcgagatg
    16981 cacggtcccg gctcctgcgg cctgctcgca ctgccacggc accggcccgt ccagcgccca
    17041 gtcgaccttg aaggtggcga agtcccactg gaagcgctcc aggtcggaca gcagctgccg
    17101 gggcaggtcc tcgggggcga cgagttcgcc gtagagggcg gggacggaca cgtcggcgag
    17161 gacggcacgc cgggcgggga cggtctcccc gtcggcgagg cgtacggcga ccgcgcgccc
    17221 gtcgcggacg acgacgcgtt ccacgtgccg cccgcaccgc agcgctcccc cacgtgactc
    17281 caggcgccgc acgagggcgt cggtgagggc gcccgccccg ccgaccggta cggggaagcc
    17341 gtaggtctgt ccgagcatgg acatcagcca gccgaagccg ccgctgccgg cggcctcggg
    17401 tgcgaggtcg gcgtgcaggg cgttgcccgc gagcagcagc ccgccgccct cgccgcggaa
    17461 ctcctcctcc gccatgcgcc gcaccggcag cacgagggtg cgcgccatgc gcagcccgcc
    17521 ggtgccgcgc agccgtacgg cgagccgcag cccggagcgg accggcggga acggcgtgaa
    17581 cagggcgtcc agcaggtcgg gacgcagggt gtcccacatg gagtgcagcc ggcgccaggc
    17641 gtcgccgtcc ccgggcgcga aggtgtcgag ggagtccgcg gtgacgtcga cgtcgcggtc
    17701 caggatcgcg cagcggccgt cgctcagggg gtgggcgacg acgtgcgggg cgtggctcca
    17761 gcgcagtccg tgctcctcca ggccgagccc ggagacgacc ggggatgcgg cggcgagcgg
    17821 atagaaggag ctgaacaggt cgttggcgaa gtcggggtgg acgccgtggt cgtgacgcac
    17881 ggcgccgccg ggttcgggct gttcctccag gaccgtgacg ctccagccgg cgtcggcgag
    17941 caggttcgcc gcgaccaggc cgttgggccc cgcgccgatg acgacggcgt cagccacggg
    18001 cgcctcccgc gtcgggctcc ggcggcacga tctggccgag cggccggcgc tcctccgtct
    18061 cggcggcctc ggtctcgacg aggtgcgcga gccgggcgag catggcgcgg tggcggatct
    18121 ggatgagcgc ctcgactccc acgttgtgca ggaagccgcc cgccccgcgc agggggtgtt
    18181 cgtccacctt gacgaggcac cagtcacccc agggctgcac ctcgatggcg atgcgggcgg
    18241 tgcccagcgg gccggcgttg gcctccagtt ccagcacctc gccggggacg cagcgccgga
    18301 cgaccgtctc gttgtgcagc ttcagcgggc cgacgggcac ctcgtagcgg atggcggagc
    18361 cgagctgcgg ccagtggccg cgcaccggct tcgactcgga cgtccccacc acccagtccg
    18421 cgtagcgggt gccgtcctcc agcacggacc acacggtccg cgggtcggtg cggatcaagc
    18481 gatgacggac cgccactgtt gcctcctgtg tccctgggca ccaccggtca gctctgagtg
    18541 ccccgtctga ccgccgtcaa ccaggaggcg cggccggacg ggtcaggcgg cggggcgggt
    18601 gggggccagc gcccagcgga tgcccgcggt gacggcggtg ccgagcgggc ggacgcacag
    18661 gccttcggcg ggcaggcggg gcacccgcag ctcgcgggac gcccacggcg gcagccgggg
    18721 caaggcgttc gcggcgagga cgccggacgg cagggggggg gggagtgggg aggggggggg
    18781 caggcgccgg gaacgcggcg gcggcagggg ggccgggggg gcgggcgagc ccgcgcggga
    18841 ggggggccga cccgtcgcga gcgggggccg cgttccgggc gggggacctg ttcgcccgcg
    18901 ccgaccacgc cctcggccca cgcgcccagg ccgacacggt cctcgccgtc cgccgcgccc
    18961 aggccgtgtg gccgccgctg gagcgcctgc tgcccgtacc caccgccctc gacctgaccg
    19021 acggggaact acgcgatctg ctcggcggcg cggccggccg gctggccggg cacggcatcg
    19081 acgtcacctg gcccaagacg tccaccggtg cgctcaccgc ccgcgcggtg gccggcgccg
    19141 accggatgcc gcccgccgac ctgcgctcct tcttcggcgg cgacggcacc gtcgacctgc
    19201 gctggcgcct cgaactggac ggcgaccccc tcaccgacga cgaagcggcc accgtcgccg
    19261 acggcggggc cgtcgcccgg ctgcgcggcc gctggatcct cgtcgacgcc ggcatcgccc
    19321 gcaaggcccg cgaccgccgg ctgccgccgc tcaccgccat cgaggcgctc gccgtcgccc
    19381 tcaccggcca caccgacatc ggcggcgaac gcgtgcgggt ggcgcccagc gcctggctgg
    19441 acgccctgcg ccgcgccctc gccgaccccg acggcggcga cggagcggtg gaccagcccg
    19501 cccgcctgac cgccaccctg cgcgactacc agctgcgcgg actgcgctgg atggaccgca
    19561 tgacctccct cggcctcggc ggctgcctcg ccgacgacat gggcctgggc aagaccatcc
    19621 agctgatctc gctgcacctg ctgcgccagg aacgccccga ggaccgcggc cccaccctcg
    19681 tggtctgccc cgcctccctg ctgggcaact gggaacgcga agtgggccgc ttcgcgccgg
    19741 gcaccccggt acgccgccac cacggccccg gccgcaccct ggacggcgcc gacgagggct
    19801 tcgtcctcac cacgtacggc accatgcgcc tggacgccgc ccggctcggc gcacacacct
    19861 ggggcctggt cgtcgccgac gaggcccagc acgtgaagaa cccccactcc tccaccgcca
    19921 aggccctgcg gcagatcggc gcccgcgccc gcatcgccct caccggcacc ccggtggaga
    19981 acaacctctc cgaactctgg gccgtcctcg actggaccac gcccggactc ctcggcaccc
    20041 accgccggtt ccgcacccgc tggatcgccc gcgtcgaggc cgaacgcgtc ctcgccgcga
    20101 acggtgacgg cgaacagcac accgcccgcc tcctgtcgga gctggtacgg ccgttcctgc
    20161 tgcgccgccg caagaccgac ccgggcatcg cacccgaact gccgcccaag accgagacgg
    20221 accggccggt cgcgctcacc gccgaacagg acaccctcta ccgcaagcag gtggagacgg
    20281 tgatgggcga gatccgcgcc ggcgcggcga gatccgcgcc ggcgcgggcg gcatcgcccg
    20341 cagcggcctg gtgctgaagc tgctcaccgg cctgaagcag atctgcaacc accccgccca
    20401 gttcctcaag gaggaccagg ccccgctcac cggccgctcc gggaaactgg aactgctcga
    20461 cgaactcctc gccaccatca ccgccgaggg cggcgccgcc ctgatcttca cccagtacgt
    20521 caccatggcc cgcctcctcg aacgccacct gcgcgaccgc ggcacccccg ccgccctgct
    20581 gcacggcggc accccggtgg ccaggcgtga ggaactcgta cggcgtttcc aggacggcga
    20641 gttccccgtc ttcctgctgt cgctgaaggc ggccggcacc gggctgaacc tcacccgcgc
    20701 cgaccacgtc gtgcactacg accgctggtg gaacccggcg gtcgaggcgc aggccaccga
    20761 ccgcgcccac cgcatcggcc agacccggcc cgtccaggtg caccggctga tcgccgaggg
    20821 caccgtcgag gaccgcatcg cggccctgct ggaggcgaag aaggaactgg ccgactcagt
    20881 cctcggctcg ggcgagcagg ccctgaccga gctgagcaac gacgagctgg ccaacctggt
    20941 ggaactgagg agcatggcat gagcgaggca cagcgcagcg gcgcacgggg cttccccgcc
    21001 ttcgcggcac gccggggcgg ccgcgcccgc ggccagtcct tctgggccgc gcagtgggcc
    21061 ggggccgtgg aggacgtctg gccggaggag ggacccctga aaaagggccg ctccttcgcc
    21121 cgcaccggcc gcatcggccc gatcacggtc agccccggcc gggtggccgc ggagatgtac
    21181 gggggagagg agacgtgcac gacgcggctg acgctgaccg tgctggacga cgacgcgtgg
    21241 gacctgctct gggagaagac cgccgaccgc ccggccgagg ccgaggcgct gctggccggc
    21301 gacctccccg aggacctgct ggaggccgtc gaggacgccc gggtgaacat gctgcccggc
    21361 tacggcgacc tcgacgccga ctgcgactgc gacggtctcg accacccctg cccgcacgcc
    21421 accgccctcg cctaccagct gtcctggctg ctggacgccg acccctggct gctgctcctg
    21481 atccgcggcc gcgccgccgg ggaggcggtg gaggagctca agtcggcgct gctgctgcgg
    21541 gcgttggccg gcggcgagga ggagaacgac ctgacgtcca ggcgggtcgg gcgggcgcgg
    21601 cggctgctgc tggaggggtg gccgccgagc gacgtcgcgg ccgccgccgg cttctacgac
    21661 caggcccacc tgacccggca cttccgccgg ctggtggggg tcactccggg acgctaccgg
    21721 gcgacggacg cagcaggtgc gtgaacgcgt ccaggttgcg cgtcgactcg ccccgcgaga
    21781 cgcgccatgc gtactccttg cggatcgcgg aggcgaagcc cagctccagc agggtgttga
    21841 agctgccgtc ggcggcctcc aggacctgcc cgagcagccg gtcgagttcc tcgggggtga
    21901 tcgcgggcag cggcaggcgg ccggtgacgt agatgtcgcc gagcgggtcg acggcgtaac
    21961 tcacgccgaa cagcttgagg ttgcgctcca ggagccagcg gtggacgccg gtctcgttct
    22021 cgtcggggtg gcggatgacg aaggcgttga gggacagggt gtgccggccg acgatcaggg
    22081 agaccgtcgt ggacagcttg cgggtgccgg ggagtttcac cacgtagttc ccgggcgccg
    22141 ggctctccca ctccagctcg gcgtccttca gcacgccctc gacgatccgt gccgcccgct
    22201 gctccgcttc cgtgtcagcc atggtgggag cgtacgtgac ggcggtgggc gtgggtcgcg
    22261 gccgtgtaca cgtcggccgt ggcggcggcc gcggtgtccc agccgaagga ctgggcgtgc
    22321 cgggcggcgg cctcgcccat gcgtgcggcg agctccggcc ggtcggcgag gtcgcgcagg
    22381 acgcgcgcgt aggcggccgg gtcgtggccc tggatcagga agccggtctc ctcgtcgcgc
    22441 acggcgaccg ggaggcctcc gacggccgcg gcgagcaccg gggtgccgga cgcctgcgcc
    22501 tctatggcga ccaacccgaa cgactcgctg tacgacggca tgaccagcac ggacgcggcg
    22561 cggaaccagt ccgcgagctc ctcctgcccg accggcgggt ggaagtggac gacatcggcg
    22621 atgccgagcc gggcggcgag cttctgcagc ccttccggct tggcgaggcc gctgccgctg
    22681 gggcctccga cgacgggcac gcagacgcgg gagcgcagct cgggccggtc ggcgagcagc
    22741 acggccaccg cgcgcagcag cacgtcgggt gccttgaggg gctggatacg gccggcgaag
    22801 agcgggatca gcgcgtccct cggcagcccc aggcgggcgc gggcggcggc gcggccgtcg
    22861 gcggggcgga agcggccgag gttcacgccg gggtggacga cggcgacctt ggcggggtcg
    22921 gcggcgtagt ggtggacgag ctcgccggcc tcctcggtgg tgttggcgat cagccggtcc
    22981 gcggcggcga cgatctgggt ctcgccgatc acgcgggcgg cgggctcggg tgtgtcgccg
    23041 tcggcgaggt tggcgttctt gaccttggcc atggtgtgca tggcgtgcac cagggggacg
    23101 ccccagcgct gggcggccag ccagccgaca tggccggaga gccagtagtg ggagtggacc
    23161 aggtcgtagt ggccgggacg gtgcccggcc caggcctgca tcacgccgtg ggtgaaggcg
    23221 cacagctggg cgggcaggtc ctccttggcc agtccctcgt aagggccggc gtcgacgtgc
    23281 cggacgagga cgccgggcgc gagctcgacg acgggcggga gggcggccgt ggtggcccgg
    23341 gtgaagatct ccacctcgat gttgatcgcg gcgagccgct gggccagctc cacgatgtag
    23401 acgttcatgc cgcccgcgtc gccggtgccc ggctg
//
