LOCUS       NZ_RAII01000001        26697 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3305486
            Orig. end                         :: 3332183
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26697
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26697
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26697
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16697](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16697)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(171..566)
                     /locus_tag="EBH12_RS15505"
     CDS             complement(171..566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993204.1"
                     /locus_tag="EBH12_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF302 domain-containing protein"
                     /protein_id="WP_114872947.1"
                     /transl_table=11
                     /translation="MAYDRTVRLTDTDFGTAVTAVRRALADQGFGVLTEIDVRATLKAK
                     LDHDMEDYLILGACNPPLAQRALEADRSIGLLLPCNVVVRRDGDHALVQALDPGTMVTL
                     TGLDALTPVADEATARLDAALSSLSAA"
     gene            753..>971
                     /locus_tag="EBH12_RS15510"
                     /pseudo=""
     CDS             753..>971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027250.1"
                     /locus_tag="EBH12_RS15510"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFFVDTLEFEGLGNRSYLAGGARGAVVVDPPRDIDQVIAAAAKRG
                     VRIAYVAETHVHNDYVTGGLELARVTGA"
     gene            <1121..1380
                     /locus_tag="EBH12_RS15520"
                     /pseudo=""
     CDS             <1121..1380
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565994.1"
                     /locus_tag="EBH12_RS15520"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="TSUP family transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="LAFEMRAAVGTSLLVITANSLASLATRSGAAVSLDWAVIGPFIAT
                     AVLGAWTANASPRRSPDPACNASSPSSCWPWPPSCSPTR"
     gene            complement(1406..1684)
                     /locus_tag="EBH12_RS15525"
     CDS             complement(1406..1684)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358257.1"
                     /locus_tag="EBH12_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_048456497.1"
                     /transl_table=11
                     /translation="MELDMAAEELKSVLNRLRRAQGQIAGIIKMIEEGRDCEDVITQLA
                     AVSRALDRAGFAIIATGLQHCMAEEGQVDGDRDRMRARLEKLFLSLA"
     gene            complement(<2006..3324)
                     /locus_tag="EBH12_RS15530"
                     /pseudo=""
     CDS             complement(<2006..3324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031791.1"
                     /locus_tag="EBH12_RS15530"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="SMI1/KNR4 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLTENTVPGNADADWRTFLPRWSGEWADALPDDEAARRSRWLGFP
                     PASEERIAAMEKRLGRRMPPSYRSFLQVTDGWRHAGGFVWLLAGTADARWHDNASGLAD
                     LFEEYLEEDAEPEERREAGVWRRGLQLDVESDATYVLLDPEDVDDDGEWAVYTWASWRA
                     DAPERYPDFRAFMEAMFREFHSLRSHRAGRGPEFVNATTRELDARVEDARRDALRGDWE
                     RALKTLDEAKGYGRPRAAGLGDQIRRLLGLTYMVYFPGLVTDPRYASELLPPLVAEHAA
                     RSHDDAVLTNHLRGADEALMSRARAILDQVRAGTYRYTAPGPFGAAVDRARELSRRGDT
                     DQAWRALIDALPLWQPLGPDHLAPLGWVTDPLLGPLLTPERSRAFLSTPRGGPAGRGVL
                     PGTRPGPAGPGPTGGPGQAPDARPTASSQWTW"
     gene            3496..3741
                     /locus_tag="EBH12_RS15535"
     CDS             3496..3741
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134529.1"
                     /locus_tag="EBH12_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5133 domain-containing protein"
                     /protein_id="WP_048456498.1"
                     /transl_table=11
                     /translation="MIMPAEKELRAVLARFAQARIEHDVLPTGRTSRALEDATYTLCVI
                     TGSRTVEQALRAADALLDQYTAGRAGLRREDETLAA"
     gene            complement(3774..4289)
                     /locus_tag="EBH12_RS15540"
     CDS             complement(3774..4289)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014794.4"
                     /locus_tag="EBH12_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_114872946.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.2e-24, bitscore:
                     84.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANALPQAIGAQAAAGRRRQVVAPCGDGGLGMLLGDLITLRHLRL
                     PVKVVVLDKGTLSFVELEMKAGGILKYGTDLDDLGFAAVARAAGIAGVRADRAGELDDA
                     LREAFVHDGPAVVDARMASQELSPPPHLTYDEVKGFSLFVTRTVLSGEGNELLEPAKTN
                     VHELPLPH"
     gene            complement(4178..4630)
                     /locus_tag="EBH12_RS35690"
     CDS             complement(4178..4630)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EBH12_RS35690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_196421279.1"
                     /transl_table=11
                     /translation="MLNDAERVTILGGAGCEGCHDEVMALAGREKPAGGFADRLTQHYR
                     RVRAHLDAPAEARPHDAPMRPQHVAAAVDRPAEGDTIFAADVGTPTVWAARHLTMNGHR
                     QLIGSFNQASWPTRCRRPSARRRPRAGGGRWWHRAGTAGSACCWAT"
     gene            complement(4874..5275)
                     /locus_tag="EBH12_RS15550"
     CDS             complement(4874..5275)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026182.4"
                     /locus_tag="EBH12_RS15550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tautomerase family protein"
                     /protein_id="WP_114872944.1"
                     /transl_table=11
                     /translation="MPLYTCTCVQGSLPSDVKDRLAAEITSIHADLNGVPPDYVNVVFA
                     ETPQENVYVGGRPGTPLLINGWARRGHPQVSTTRLALAIAEAASRTSGIPREHVMVVIL
                     DSAARSAVEAGRILPDPGQEAEWLAAGRS"
     misc_feature    complement(5428..5442)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.04"
                     /tool="antismash"
     gene            5525..6127
                     /locus_tag="EBH12_RS15555"
     CDS             5525..6127
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526903.1"
                     /locus_tag="EBH12_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_048456500.1"
                     /transl_table=11
                     /translation="MTRARDLALVAADPRDRTIVEQGDLSLALAGAELIDLLDAEALTL
                     DGTLLVPAGPAPAGDRLLSEAAQWLADGGPGETVDDWLWRRGRDLAGRYRTVLEEEGLV
                     EPERRSRNPLRREHTAPADPSAARAAEERRSSGEPVLGALAAAAGLTEQGGEAFDGLDD
                     ERTTVLAAVLQAVTELAGERQRRTIEAAAFDNIWRGD"
     gene            6210..6581
                     /locus_tag="EBH12_RS15560"
     CDS             6210..6581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523313.1"
                     /locus_tag="EBH12_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_241563189.1"
                     /transl_table=11
                     /translation="MDTPACDAGGGDTGRHPAQCDQTPATGYFPSGHTATATVAYGTAT
                     LLLLPLLGSPAVRRGLIALCALLVLGASYGLVRRGYHWPLDVVGSWCLGTMLLTGVVLV
                     SRSSRRTSVGTPSRRSGPS"
     gene            complement(6520..8325)
                     /locus_tag="EBH12_RS15565"
     CDS             complement(6520..8325)
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657524.1"
                     /locus_tag="EBH12_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 18 protein"
                     /protein_id="WP_121740391.1"
                     /transl_table=11
                     /translation="MTAVSLGLPEVPATLAVRRRSRQIQVGSVAVGGDAPVSVQSMTTT
                     RTSDIGATAGATVTSPVHSGASALKATPAGSDNARCAQTVTVKPDSAYTLSGYVRGAYV
                     YLGASGTGTTDVSTWTQSAPDWQKLTTTFRTGPSTTRVTIYTHGWYGTGAYHADDITLV
                     GPGGETGQPPAPPTGLTASGATSTSVALSWSPAAGATSYAVYRDGARIRTVTGTSTTVT
                     GLSPSTAYAFQVAALNDAGESARSATVTATTSAPDSGGGDSGLPEHALVGYLHASFANG
                     SGYTRLADVPDSWDVIDLAFGEPTSVTSGDIRFERCPATECPGVESDAEFKAAIRAKQA
                     AGKKVLISIGGQNGQVRLTTTAARDTFVSSVSRIIDEYGLDGLDIDFEGHSLSLDTGDT
                     DFRNPKTPVIVNLISALKTLKAKYGDDFVLTMAPETFFVQLGHQFYGSGPWGGQDPRAG
                     AYLPVIHALRDDLTLLHVQDYNSGPIMGLDGQYHSMGGAGFHIAMTDMLLTGFPVAGDA
                     NRVFPPLRPDQVAIGMPATVNAGNGHVPPAEVVKTLDCLTRNTDCGSYRTHGTWPSLRG
                     LMTWSINWDRFGGWEFQRTFDGYFG"
     gene            complement(8332..9354)
                     /gene="hpnH"
                     /locus_tag="EBH12_RS15570"
     CDS             complement(8332..9354)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386169.1"
                     /locus_tag="EBH12_RS15570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_048460834.1"
                     /sec_met_domain="PF04055 (E-value: 1.5e-16, bitscore: 59.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 7.3e-08, bitscore: 30.8,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIKVATYLAEQKLRRRDKFPLIVELEPLFACNLKCEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIARQLVARRKYVF
                     LCTNALLMRKKMDKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTVVEVLNYLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FRKAFSGGNRRRWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEDTDWDKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAMRETVSSNRE
                     "
     gene            complement(9360..10001)
                     /locus_tag="EBH12_RS15575"
     CDS             complement(9360..10001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431357.1"
                     /locus_tag="EBH12_RS15575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_114875432.1"
                     /transl_table=11
                     /translation="MNGRPAPAPLLIACALGIEQFALRRRERTTPGGPVTVLRTGMGPA
                     AAERSVTRVLADPALHGAAVLATGFCAGLAPGMHPGDLVVAEETRDPRGTVPCVGTELL
                     VKELMRAVPGRTVHTGPLTGSDHVVHGHERSDLLATGAIAVDMESAATLLSAVRAAERP
                     VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFYEWHRSLLLPRR"
     gene            complement(10001..12040)
                     /gene="shc"
                     /locus_tag="EBH12_RS15580"
     CDS             complement(10001..12040)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527747.1"
                     /locus_tag="EBH12_RS15580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_114875431.1"
                     /sec_met_domain="T2TS (E-value: 1.1e-148, bitscore: 494.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGAASPSRLTAASEHDTDSPGAAGVPDIAARAVRRAT
                     DLLLSRQSDEGWWKGDLETNVTMDAEDLLLRQFLGIRDEDTTRAAALFIRGEQREDGTW
                     ATFFGGPGDLSATVEAYVALRLAGDAPEAEHMAKASAWIREQGGIAASRVFTRIWLALF
                     GWWKWQDLPELPPELIWFPTWVPLNIYDFGCWARQTIVPLTIVSAERPVRPAPFPLDEL
                     HADPANPNPPRPLAPATTWDGAFQRLDRGLHKLRRAVPRRLRRAAMNTAARWIIERQEN
                     DGCWGGIQPPAVYSVIALHLLGYDLNHPVMRAGLDSLDRFALWREDGARMIEACQSPVW
                     DTCLATIALADAGVPADHPALVKAADWMLGEQVVRPGDWSVRRPHLPPGGWAFEFHNDN
                     YPDIDDTAEVVLALRRVRHHDPERLDNAVGRGVRWNLGMQSRNGAWGAFDVDNTSPFPN
                     RLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAQDPRTRRGVEWLLAEQELDGSWFGRWG
                     VNYIYGTGSVVPALTAAGLPTSHPAIRRAVAWLEKVQNDDGGWGEDLRSYSYVKEWSGK
                     GASTASQTAWALMALLAAGERDSEAVERGVAWLADTQREDGSWDEPYFTGTGFPWDFSI
                     NYHLYRQVFPLTALGRYVHGEPFAAKPAEVPAGSAQALADAKGS"
     misc_feature    12146..12161
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    complement(12149..12164)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(12157..13221)
                     /locus_tag="EBH12_RS15585"
     CDS             complement(12157..13221)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972234.1"
                     /locus_tag="EBH12_RS15585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_078895345.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1e-57, bitscore:
                     194.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPASQAARRTAVDVSALLERGRTLATPVLRAAVDRLAPPMDTVA
                     AYHFGWIDAQGRPADGDGGKAVRPALAVLSAEVTGAAGETGVPGAVAVELVHNFSLLHD
                     DLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTRASR
                     ALIDGQAQDISYEHRDRVSVEECLEMEGNKTGALLACASSIGAVLGGADERTADALERY
                     GHHLGLAFQAVDDLLGIWGDPESTGKQTWSDLRQRKKSLPVVAALAADGPAATRLGEIL
                     AADAKSSDFANFSEEEFAARAALIEEAGGREWTAEEARRQHTIAIEALDVVDMPDRVRE
                     QFTALADFVVVRKR"
     gene            complement(13293..14723)
                     /gene="hpnE"
                     /locus_tag="EBH12_RS15590"
     CDS             complement(13293..14723)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133315.1"
                     /locus_tag="EBH12_RS15590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_114875430.1"
                     /sec_met_domain="DAO (E-value: 4.1e-09, bitscore: 35.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHGTRSEGAPHTDGPVPPGRHAVVVGGGLAGTTAALALADAGVR
                     VTLLEGRPRLGGLAFSFKRGDLTVDNGQHVYLRCCTAYRWFLDRLGGAGLAPLQDRLDV
                     PVVDAARPEGRRLGRLRRDPLPVPLHLGRSLAAYPHLSLADRARVGRAALALKGLDLDD
                     PALDEQDFGSWLAAHGQSPRAVEALWDLVGVATLNAVAGDSSLALAAMVFKTGLLSDPG
                     AADIGWARVPLGDLHDRLAREALDAAGVRTATRTRVSSVRADGDGGWSVDIPGETLRAD
                     AVVLAVPQREAYDLLPAGALDAPDRLLGIDTAPILNVHVVYDRTVLTRPFFAALGTPVQ
                     WVFDRTHASGLRHGQYLALSQSVAHDDIDAPVADLRERYLPELERLLPRARGAEVLDFF
                     VTRERTATFVPAPGVGRLRPGARTKAPGLYLAGAWTATGWPATMESAVRSGVGAADAAL
                     GALGRPRPRHLFALEEAA"
     gene            complement(14839..15789)
                     /gene="hpnD"
                     /locus_tag="EBH12_RS15595"
     CDS             complement(14839..15789)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994383.1"
                     /locus_tag="EBH12_RS15595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_048460829.1"
                     /sec_met_domain="phytoene_synt (E-value: 9.6e-57, bitscore:
                     190.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.9e-70,
                     bitscore: 235.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTVESQPSASAPVLAAYSYCETVTGQQARNFAYGIRLLPTPKR
                     RAMSALYAFSRRVDDIGDGPLPEDVKAARLEDTRALLTRIREGAVEEDDTDPVAVALSH
                     AAAHFPIPLGGLDELIDGVQMDLRGETYETWDDLKVYCRCVAGSIGRLSLGVFGTEPGA
                     RGVERASEYADTLGLALQLTNILRDVREDAENGRTYLPADDLAKFGCADGFAGPTPPQG
                     SDFAGLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLR
                     GRVSLPGREKAYVAVRGLSGLDTRHVARRTVGRRD"
     gene            complement(15786..16697)
                     /gene="hpnC"
                     /locus_tag="EBH12_RS15600"
     CDS             complement(15786..16697)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042802.1"
                     /locus_tag="EBH12_RS15600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_121740713.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.5e-35, bitscore:
                     119.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 8.7e-37,
                     bitscore: 125.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAGRARPGDLERATLDKAAAENFPVAPFFLPRAWRDDLMAVYG
                     FARLVDDIGDGDLAPGGADARALGVPEDKAGDRLTLLDALEADLHRVFDPTGPAPRHPL
                     LLRLERTVRRRALTPEPFLGLIAANRQDQLVTRYETYDDLLAYCELSANPVGRLVLAAT
                     GTATPERIRRSDAICTALQIVEHLQDVAEDLGRDRIYVPAADMKRFHVQEADLAEPTAG
                     ASVRALVAFQAQRALDLLDEGAPLVGSVRGRLRLLLAGFVAGGRAAVRAIAAADHDVLP
                     GPPKPGTLQLLREAGVTLRGKG"
     gene            complement(17059..17838)
                     /locus_tag="EBH12_RS15605"
     CDS             complement(17059..17838)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330378.1"
                     /locus_tag="EBH12_RS15605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_048460828.1"
                     /transl_table=11
                     /translation="MADDKTGARVPTVIADDLHIVYRVNGTRSGKGSATAALSRILKRG
                     EERGVRKVHAVRGVSFVAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAERGKVYTDGQPS
                     LLGVNAALMNDLTGERNIILGGLAMGMSREEIKERYQDIVDFSGINEKGDFITLPMRTY
                     SSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQKRSEARIRELRKEAGTVFLVSHNN
                     KSIRDTCDRVLWLERGELRMDGPTDEVLREYEKFTGK"
     gene            complement(17831..18766)
                     /locus_tag="EBH12_RS15610"
     CDS             complement(17831..18766)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964854.1"
                     /locus_tag="EBH12_RS15610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_048460827.1"
                     /transl_table=11
                     /translation="MSETTHDGTVAVGAPVSPDEGLPAAELAAKYGLSVSGARPSLGEY
                     VRQLWGRRHFILAFSQAKLTAQYSKAKLGQLWQVATPLLNAAVYFFIFGLLLGARRGIP
                     SDVYVPFLVTGVFVFTFTQSSVLAGVRAISGNLGLVRALHFPRASLPISFALQQLQQLL
                     FSMIVLVVIMVAFRSYPDLSWLLVVPALGLQFVFNTGLALIFARMGSKTPDLAQLMPFV
                     LRTWMYASGVMFSIPAMLEDKNVPSWVADVLQWNPAAVYMDLVRYALIDKYDSTYLPPH
                     IWAFGLGWAVLAGVVGFVYFWKAEERYGRG"
     gene            complement(18863..19747)
                     /locus_tag="EBH12_RS15615"
     CDS             complement(18863..19747)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983096.1"
                     /locus_tag="EBH12_RS15615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_048460826.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.8e-12,
                     bitscore: 46.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAGMKVGAVVITMGNRPDELRALLDSVAKQDGDPVEVVVVGNGS
                     PVPDVPEGVKTVELPENLGIPGGRNVGIEAFGPSGRDVDILLFLDDDGLLAHTDTAELC
                     RKAFAEDPSLGIISFRIADPDTGVTQRRHVPRLRASDPMRSSRVTTFLGGANAVRTQVL
                     AEVGGLPDEFFYAHEETDLAWRALDAGWMIDYRSDMVLYHPTTAPSRHAVYHRMVARNR
                     VWLARRNLPAPLVPVYLGVWLLLTLLRRPSGSALKAWFGGFKEGWTSPCGPRRPMKWRT
                     VWRLTRLGRPPVI"
     gene            complement(19744..20487)
                     /locus_tag="EBH12_RS15620"
     CDS             complement(19744..20487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676198.1"
                     /locus_tag="EBH12_RS15620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_078895344.1"
                     /transl_table=11
                     /translation="MHPAGVKDRRSGEHWMGRLYMREVSLRVDRYLVNTRVTPNQLTYL
                     MTLCGVLAAPALLVPGITGAVLGVVAVQLYLLLDCVDGEIARWRKQYSLAGVYMDRVGA
                     YLTDAAVLVGLGLRAADLWGTGRIDWLWAFLGTLAALGAILIKAETDLVGVARHQNGMP
                     PVKESASEPRSSGMALARKAAAALKFHRLILGIEASLLILLLAILDSARGDLFFTRLGT
                     AVLAGIALLQTLLHLVSVLVSSRLK"
     gene            complement(20501..21517)
                     /locus_tag="EBH12_RS15625"
     CDS             complement(20501..21517)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020135426.1"
                     /locus_tag="EBH12_RS15625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_121740392.1"
                     /sec_met_domain="Fe-ADH (E-value: 9.3e-20, bitscore: 69.4,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 5.1e-07, bitscore:
                     27.8, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPGALDDLACVLADERISQSGRLAIAVSGGSGARLRDRVAPSLP
                     GADWFEVGGGTIDDAVRLAGAIQGGRYDAVVGLGGGKIIDCAKFASARVGLPLVAVATN
                     LAHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLNVIREAPVRFVRSGIGDVVSNISAV
                     ADWELSHRVNGEKVDGLAAAMARQAGEAVLRHPGGVDDDSFLQVLAEALVLTGISMSVS
                     GDSRPSSGACHEINHAFDLLYPQRAAAHGEQCGLGAAFAMYLRGAHEESAAMAEVLRRH
                     GLPVLPEEIGFSVDEFVRVVEYAPETRPGRFTILEHLALTTEQIKDVYADYVKAIGS"
     gene            complement(21549..22301)
                     /locus_tag="EBH12_RS15630"
     CDS             complement(21549..22301)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="EBH12_RS15630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_114873743.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.3e-10, bitscore:
                     39.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGAEGDPDAVTVLDLTLG
                     NFAEIGLTEVGVVVGYRKEAVYERQAALEAKYGLKLTLIDNDKAEEWNNAYSLWCARDA
                     LKDGVILANGDTVHPVSVERTLLDARGDGRQIILALDTVKRLADEEMKVVVDPEKGMRR
                     ITKLMDPAEATGEYIGVTLIEGGAAEALADALKATFERDPQLYYEDGYQELVNRGFRID
                     VAPIGDVRWVEIDNHDDLARGREIVAGR"
     gene            complement(22383..26450)
                     /locus_tag="EBH12_RS15635"
     CDS             complement(22383..26450)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019985580.1"
                     /locus_tag="EBH12_RS15635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rne/Rng family ribonuclease"
                     /protein_id="WP_241563191.1"
                     /transl_table=11
                     /translation="MVRRAAAPAGAPASAEAAETVVPAAQPASEAASPAPEPAADTTED
                     AAPRRTRRRATRTVTAPASAADTGAADETAAAPESAETSAEPAADTTEDAAPRRTRRRA
                     TRTVTAPAPAADTGAVDETAAAPGNTETPAEPAAAATEDAAPRRTRRRAARTVTAPAAE
                     TAAETPAEPEAEEPAAEETAPAAAGTAAEPAADVAEDAAPRRSRRRASRRASAPAGAPA
                     AEATAEAVAALGDDETEQAAPTTEEAPVTENDKQDETPAEAPAAQAPAEEGGPRRRRRV
                     VRKAAAGFAEPARSARGAEAEDKDDAPRRPARPAVAVFQPPVFTEPRFQTPERAAAEAA
                     AGVAESAEPEEETEELPEEQPAASRRRRRRKGASDEPEAAAPAAAEETSEANAEEAPDQ
                     AEDRADSDEGDDHDDQESSGSRRRRRRGGRRRRRGESADADSGEQQDDDTEAAERAGTE
                     QSARDAEDTDGQSDEDAEEREETDDNGGSSSSRRRRRRRRRAGDSGGEPEPSADDPERT
                     VVKVREPRPPREKGAEPSDEVQSIKGSTRLEAKKQRRREGREQGRRRVPIITEAEFLAR
                     REAVERVMVVRQHGDRTQIGVLEDGVLVEHYVNKEQATSYVGNVYLGKVQNVLPSMEAA
                     FIDIGKGRNAVLYAGEVNFDALGMSGGPRRIESALKSGQPVLVQVTKDPIGHKGARLTS
                     QVSLPGRYLVYVPEGSMTGISRKLPDTERSRLKTILKKIVPEDAGVIVRTAAEGASEDE
                     LRRDVERLQAQWEEIKKKSKNGGTAPTLLYGEPDMTVRVVRDIFNEDFSKVIVSGDEAW
                     GTVHGYVSHVAPDLADRLQRWTSEVDVFATYRIDEQLAKALDRKVWLPSGGSLVIDRTE
                     AMVVIDVNTGKFTGQGGNLEETVTRNNLEAAEEIVRQLRLRDLGGIIVIDFIDMVLESN
                     RDLVLRRLLECLGRDRTKHQVAEVTSLGLVQMTRKRVGQGLLESFSETCVHCNGRGVIV
                     HLDQPSFSGGGKRRKRARAGAADQPHEHEAAVETPEQEAEAESETPAEVAAEAAEPAAL
                     PSPEFTPDEELYSSAAEAEAAASRGRTRRRASRRASAPAGSPQRESAKGGRKQAEERAE
                     EAPAAEETRAVPTAQDVTATEEARRPVQPESAAEALAEPAAAEDVVVPQAEEAAPKGRT
                     RRRATRKATAPAGSPAGAEAAVVTVAESARTEEAPKAEETPAEAAVPEAAPEASSPARP
                     RRRAVRKPSTSTASEDTAVVVLPSVPADEQKRAEEPAAEPEAAEPVEGAEGAEEAAPAK
                     KAARKTAKKATAKKAATKKTTTAKKTAAKKTTTAAKKTTAKKSTAKKATTKKTAAAEQQ
                     APSSVTAAADES"
ORIGIN
        1 cctgaaactc tccgctccgg ccaggtgagg acacccgcgg cggagcacct ccccgtggcc
       61 ctgccgtcct ccccggttcc gtggccggcg gactgccgcc gtacaccggc cctggcacac
      121 gtggccaccg gccgggccct gtcgcgacgg tgcccccggg tccgggtggg tcaggcggcg
      181 gacagggaac tcaaggccgc gtccaggcgg gcggtggcct cgtcggcgac gggcgtgagg
      241 gcgtcgagtc cggtgagggt gaccatggtg cccgggtcga gagcctggac gagcgcgtgg
      301 tcgccgtcgc gacggacgac gacgttgcag ggcagaagca gtccgatgga gcggtcggcc
      361 tccagcgccc gctgggccag gggcgggttg caggcgccca ggatcaagta gtcctccatg
      421 tcatggtcga gcttggcctt cagggtggcc cgcacgtcga tctcggtgag gacgccgaac
      481 ccctggtcgg ccagggcccg gcggacagcg gtgacggcag tgccgaagtc cgtgtcggtc
      541 aggcggacgg tgcggtcgta agccacggtg cgctgatccc ttcgatgctg aatgcctggt
      601 tgccttgata ccccgcctgg tacccgccgc ggtgaacgca ataccggacg agccatccgg
      661 acggagaccg gagaaacccc ctaggtatct ctgtcagggt gagcgaacca gataccgtcc
      721 ggggtataca gcattctgga ggagccgcag ccgtgttctt cgtcgacacc ctggaattcg
      781 agggcctggg caaccgcagc tacctggccg gcggcgcccg cggcgcggtg gtcgtcgatc
      841 cgccgcgcga catcgaccag gtgatcgccg cagcggcgaa gcgcggggtg cgcatcgcgt
      901 atgtggcgga gacccatgtg cacaacgact acgtcaccgg cggcctggag ctggcccggg
      961 tgaccggcgc ctcctatcaa ggcccgcact cgcaccggcg acggcgccgc cgtactgctc
     1021 gacgtgcgcg agacgcagga gtggagcgcc gggcacgcgc ccggcgccgt ccacctgccc
     1081 ctgcccctgt cccggctgga ggccggcgcc gccctgccgc ctggccttcg agatgcgggc
     1141 cgccgtcggc accagcctgc tggtcatcac ggccaactcc ctggcctcgc tcgccacccg
     1201 ctcgggcgcc gccgtctccc tcgactgggc ggtgatcggc cccttcatcg ccaccgccgt
     1261 cctgggcgcc tggacggcaa acgcctcgcc gcgaaggtct ccggaccctg cctgcaacgc
     1321 gtcttcgccg tcgtcctgct ggccgtggcc gccttcatgc tcgccgacgc ggtgacgtga
     1381 gacgccgccc gggcgggggc cgcgctcagg ccagcgagag gaacagcttc tccagccggg
     1441 cacgcatccg gtcccggtcg ccgtccacct ggccctcctc ggccatgcag tgctgcaacc
     1501 ccgtcgcgat gatcgcgaag ccggcccggt ccagggcccg ggagaccgcc gcgagctgcg
     1561 tgatcacgtc ctcgcagtcc cgcccctcct cgatcatctt gatgatcccc gcgatctggc
     1621 cctgcgcccg ccgcagccgg ttgagcacgc tcttcagctc ctcggccgcc atgtccagtt
     1681 ccacacatcc tccttcattc ataccccttg gggtatgtta gcccgttcgg tgcttctccc
     1741 ggacgaaaag acgaagagca acctcacgca catgagcacc ccctcgtcgt catcggtccc
     1801 gcccggaccg ccgagcactc gaaaacctac gccgcgagca cgccgtggcc gccgccggtc
     1861 tcaggaaacg gacggaccgc atccatgcca ccgtcctcgg cagcgggccg accggtcacg
     1921 tgggcacccg cggacagcgg cgggatcccg cagcgcccat cgcaggcgtg ccgagccccg
     1981 agtccggcgc gtcctcgtcg cccggacgtc cgggcagggc ctcgggcgtc accatgtcca
     2041 ctgcgacgaa gcggtaggcc gtgcgtccgg tgcctgtccg ggtccgccgg tcggcccagg
     2101 tccggcgggt ccgggccggg tgcccgggag gacgcctcgt ccggccggac cacccctcgg
     2161 ggtggacaga aatgcacggc ttcgttccgg cgtcagcaac gggccgagga gcggatcggt
     2221 gacccagccg aggggggcca ggtgatccgg gcccaagggc tgccacaggg gcagggcgtc
     2281 gatcagggcg cgccatgcct ggtcggtgtc gccccggcgg gatagttcgc gtgcccggtc
     2341 gaccgccgcg ccgaagggac cgggggccgt gtaccggtac gtgccggcgc gtacctggtc
     2401 cagtatcgcc ctggcgcggg acatcaaggc ttcgtcggca ccccgcaggt ggttcgtcag
     2461 gacggcgtcg tcgtgggaac gggcggcgtg ctcggcgacg aggggcggca ggagctcgga
     2521 ggcgtacctc gggtcggtca ccaggcccgg gaagtacacc atgtacgtga ggccgagcag
     2581 gcggcggatc tggtcgccca ggccggcggc ccgcggtctg ccgtacccct tggcctcgtc
     2641 cagcgtcttc agggcccttt cccagtcacc gcgcagcgcg tcccggcggg catcctccac
     2701 ccgggcgtcc agctctcgcg tggtggcgtt gacgaactcc ggccctctgc ccgcgcggtg
     2761 ggagcggagg ctgtggaact cgcggaacat cgcctccatg aacgcccgga agtccggata
     2821 ccgctccggt gcgtccgcgc gccaactcgc ccacgtgtac acggcccatt cgccgtcgtc
     2881 gtccacgtcc tccggatcca gcaggacgta cgtcgcgtcg gactccacgt cgagctggag
     2941 gccgcgccgc cagacacccg cctcccgccg ttcctccggt tcggcgtcct cctccaggta
     3001 ctcctcgaac aggtcggcca gtcccgacgc gttgtcgtgc cagcgagcgt ccgccgttcc
     3061 cgccagcagc cacacgaagc cgcccgcgtg ccgccagccg tcggtgacct ggaggaagga
     3121 gcggtacgac ggcggcatgc gccggcccag acgcttctcc atcgccgcga tccgctcctc
     3181 ggacgcgggc gggaagccca gccaccgcga ccgccgcgcc gcctcgtcgt ccggcagggc
     3241 gtccgcccac tcgccgctcc agcgcggcag gaaggtccgc cagtcggcgt ccgcgttccc
     3301 cgggaccgtg ttctccgtca gcatgcgccg atgctgtcac ccgccactga caccccctac
     3361 gacaccgact ggcgcaggcg ccatcggcac ccgtgtacgc cactgacgac ccgacaggca
     3421 tagagctctc cccacggggc aatcggaagc ctggcgcccc accgggtgcc ctgcacgagg
     3481 ggagacggag cgatcatgat catgccggcg gagaaggagc ttcgggcggt gctggcgcgg
     3541 ttcgcgcagg cgcggatcga gcacgacgtg ctgcccaccg gccgcaccag ccgtgcgctc
     3601 gaggacgcca cctacacgct gtgcgtgatc accggctccc gtaccgtcga gcaggccctg
     3661 cgcgccgccg acgccctgct cgaccagtac acggccggcc gtgccggtct ccgccgggag
     3721 gacgagacgc tcgccgcatg agcagccgtc ggcgcgggcg gcacgagcaa ctctcagtgc
     3781 ggcagcggta gttcgtgcac gttggtcttc gccggttcca gcagctcgtt cccctcgccc
     3841 gacagcaccg tgcgcgtgac gaacagcgag aagcccttta cctcgtcgta ggtgagatgc
     3901 ggcggcgggg acagttcctg gctcgccatg cgggcgtcga ccacggccgg accgtcgtgg
     3961 acgaacgcct cccgcagcgc gtcgtcgagt tcgcccgccc ggtcggcccg cacgccggcg
     4021 atgccggcgg cgcgggcgac ggccgcgaag ccgaggtcgt ccaggtcggt gccgtacttc
     4081 aggatgccgc ccgccttcat ctccagctcg acgaacgaca gtgtgccctt gtcgaggacg
     4141 acgaccttca ccggcagccg cagatggcgc agcgtgatca ggtcgcccag cagcatgccg
     4201 agcccgccgt ccccgcacgg tgccaccacc tgccgcctcc tgcccgcggc cgcctgcgcg
     4261 ccgatggcct gcggcaacgc gttggccatg atgcctggtt gaaggatccg atcagctggc
     4321 ggtgtccgtt catggtgagg tgccgcgccg cccacaccgt gggtgtgccg acgtccgccg
     4381 cgaagatcgt gtcgccctcc gccggccggt ccaccgccgc cgccacgtgc tgcggacgca
     4441 tcggcgcgtc gtgcggccgc gcctcggcgg gggcgtccag atgcgcccgc acccgccggt
     4501 agtgctgggt cagcctgtcg gcgaagccgc cggccggctt ctcgcggccg gccagcgcca
     4561 tgacctcgtc gtggcagccc tcacagcccg cgccgccgag gatcgtcacc cgttctgcgt
     4621 cgttcagcac gccggccgcc tcggcgatgt ctcgcggtcg ggcgtcaccc gcgaccgcgc
     4681 cctgcggacc gggtgcgtgt aggggcccgg gtcggtgagc cggcgagcag catgtcgccg
     4741 gggaccacca gcacggacac cccgcaccgc tcgacggtgg tccgcggaaa gtcggaaagg
     4801 gtgcgtcagg aagggaggac tgcggtcgcc cggggaggaa cggaggtcgc cgaggaaggg
     4861 cccggcggtc gcctcaactg cggcccgcgg cgagccactc cgcctcctga cccggatcgg
     4921 gcaggatgcg gcccgcctcc acggcggagc gcgcggcgct gtcgaggatc acgaccatga
     4981 cgtgctcccg cgggatgccg gacgtacggg acgcggcctc cgcgatcgcc agggccagcc
     5041 gggtcgtcga gacctgcgga tgtccgcgcc gcgcccagcc gttgatcagc aggggagtgc
     5101 ccgggcggcc gccgacgtag acgttctcct gaggcgtctc cgcgaagacg acgttgacgt
     5161 agtcgggcgg gacgccgttg aggtcggcgt ggatcgaggt gatctcggcg gccagtctgt
     5221 ccttgacgtc ggacggcagg gaaccctgga cacaggtgca ggtgtagagc ggcatgggtc
     5281 gtcccggaga tgggggatgg ggtggcccag cgaggggagg acacaggtcg gtgaggacac
     5341 aggtcggtga gggcgcggtt gtcggcggcc gaggcgtgtg gaaggcactt cgccgccgga
     5401 cgtccagcat cacccatccg ggggagcttc gcagctcggg aaggggggaa gggcgggacg
     5461 cgccgcgcgg gcccgggtgt gcgaccgtag aggtgacggc ctcccgtccg caccggagtt
     5521 gaccatgacc agagcgcgtg acctggccct cgtggccgcc gacccgcggg acaggaccat
     5581 agtggagcag ggcgacctgt cgctcgccct cgcgggggcg gagctgatcg acctcctcga
     5641 cgccgaggcc ctcaccctcg acggcacgct cctggtcccc gcagggcccg cgccggccgg
     5701 cgaccgcctg ctgtccgagg cagcgcagtg gctggcggac ggcggaccgg gcgagaccgt
     5761 cgacgactgg ctctggcgcc ggggccgcga cctcgccggg cgttaccgga cagtcctgga
     5821 ggaggaggga ctcgtcgagc ccgagcggcg gagccgcaac ccgctgcggc gggagcacac
     5881 cgcaccggcc gacccgtcgg cggcccgggc ggcggaggag cgccgctcgt cgggcgagcc
     5941 cgtgctcggc gccctcgcgg ccgccgccgg actcaccgag cagggcggcg aggcgttcga
     6001 cgggctcgac gacgagcgga cgacggtgct ggcggcggtg ctccaggcgg tcacggagct
     6061 tgccggtgag cggcagcgcc gtaccatcga ggccgctgcc ttcgacaaca tctggcgcgg
     6121 cgactgaccg tccggcgcgg cgaccgaccg tcgcccgccc gcaggcgtgc ggccgtcccg
     6181 tgttgccgcc cccgtgcacc ggtggtggga tggacactcc cgcgtgcgac gcgggaggag
     6241 gtgacaccgg acgacatccc gcccagtgcg atcagacccc ggcgaccggc tacttcccct
     6301 ccggccacac ggccacggcg acggtcgcgt acggcacggc gaccctgctg ctcctcccgc
     6361 tgctcgggtc accggccgtc cgccggggtc tgatcgcact gtgcgccctg ctggtcctgg
     6421 gcgcgtcgta cgggctggtg cgccggggct accactggcc gctggacgtg gtggggagct
     6481 ggtgcctcgg cacgatgctg ctgaccggcg tggtgctcgt cagccgaagt agccgtcgaa
     6541 cgtccgttgg aactcccagc cgccgaagcg gtcccagttg atcgaccagg tcatcagtcc
     6601 ccgcagggac ggccaggtgc cgtgggtccg gtaggagccg cagtcggtgt tcctcgtcag
     6661 gcagtcgagg gtcttgacga cctccgccgg gggcacgtga ccgttgcccg cgttgaccgt
     6721 ggcaggcatg ccgatggcga cctggtcggg gcgcagcggc gggaagacgc ggttcgcgtc
     6781 gcccgcgacc gggaagccgg tgagcagcat gtcggtcatc gcgatgtgga agccggcgcc
     6841 gcccatggag tggtactggc cgtccaggcc catgatcggg ccggagttgt agtcctggac
     6901 gtgcagcagg gtgaggtcgt cgcgcagggc gtggatgacg ggcaggtagg cgcccgcgcg
     6961 cgggtcctgg ccgccccagg gcccactgcc gtagaactgg tggccgagct ggacgaagaa
     7021 ggtctccggg gccatggtca ggacgaagtc gtcgccgtac ttcgccttca gcgtcttcag
     7081 ggcggagatc aggttgacga tcaccggggt cttcgggttc ctgaagtcgg tgtcgccggt
     7141 gtccagggag agggagtggc cctcgaagtc gatgtcgagg ccgtcgagtc cgtactcgtc
     7201 gatgatgcgg gagacggagc tgacgaaggt gtcgcgggcc gcggtcgtcg tgagccggac
     7261 ctggccgttc tggccgccga tcgagatcag caccttcttg cccgccgcct gcttggccct
     7321 gatcgccgcc ttgaactcgg cgtcgctctc cacgccgggg cactccgtcg ccgggcagcg
     7381 ctcgaagcgg atgtcgccgg aagtgacgga ggtgggctcg ccgaaggcca ggtcgatgac
     7441 gtcccagctg tcggggacgt cggcgagccg ggtgtaaccg gagccgttgg cgaagctcgc
     7501 gtggaggtag ccgaccagag cgtgctccgg gagaccggag tcgccgccgc cggagtcggg
     7561 cgccgaggtc gtcgcggtga cggtcgccga gcgggccgac tcccccgcgt cgttgagggc
     7621 cgccacctgg aacgcgtacg ccgtcgaggg ggacagtccg gtgacggtgg tggaggtgcc
     7681 ggtgacggtg cggatccgcg cgccgtcgcg gtagacggcg tacgaggtgg cgcccgcggc
     7741 cggtgaccag gacagcgcga cgctggtgga ggtcgcgccg gacgcggtga ggccggtcgg
     7801 cggggcgggc ggctgccctg tctcgccgcc ggggccgacg agggtgatgt cgtcggcgtg
     7861 gtaggcgccg gtgccgtacc agccgtgggt gtagatcgtg acgcgggtgg tggaggggcc
     7921 ggtgcggaag gtggtggtga gcttctgcca gtcgggggcg gactgggtcc aggtggagac
     7981 gtcggtggtg ccggtgccgc tcgcgccgag gtacacgtag gcgccgcgga cgtagccgga
     8041 gagggtgtag gcggagtcgg gcttcacggt gaccgtctgg gcgcagcggg cgttgtccga
     8101 gccggccggg gtggccttca gggcggaggc gccgctgtgg acgggtgagg tgacggtggc
     8161 gccggccgtc gcgccgatgt ccgacgtgcg cgtggtcgtc atcgactgca ccgacaccgg
     8221 ggcgtccccg cccaccgcca cggagccgac ctggatctgc cggctcctcc ggcgcaccgc
     8281 gagcgtggcc gggacctcgg ggaggcccag ggagactgcg gtcatctgtg gtcactccct
     8341 gttcgacgag acggtctcgc gcatggcgcg cagggactcc ttcagggagc ccatggtggc
     8401 gaggacggcg gtgggctcgt aaccgcagtg cgccatgcag ttggcgcagc gcgggtcctt
     8461 gccgcggccg tacttgtccc agtcggtgtc ctcgatgagc tcccggtagg tcggcacgta
     8521 gccgtcgctc atcaggtagc aggggcgctg ccagccgaac agggagtagt tggggatcgc
     8581 ccaggcggtg cacgggaagt ccaccttgcc ctcgaggaag tcgaggaaca gcggggagtg
     8641 gttgagccgc cagcgccggc ggttgccgcc ggagaaggcc ttcctgaaca gctcccgggt
     8701 ctgctccacg cccaggaagt gctcctggtc gggcgccttc tcgtaggcgt aggcgggcga
     8761 gatcatcatc tcgtcgacct tgaggtcgtc gttgaggtag ttgagcacct cgacgacggt
     8821 ctgcggggtg tcggtgttga agaacgtcga gttggtggtg acccggaagc cgcgccgctt
     8881 ggcctccttg atggcctcca cggcctcgtc gaacacgccc tccttggcga cggactcgtc
     8941 gtgccgctcc cgtagcccgt cgatgtgcac ggcgaaggcg aagtacggcg acggggtgaa
     9001 cttgtccatc ttcttgcgca tcagcagcgc gttggtgcac aggaagacgt acttccggcg
     9061 ggccaccagc tgacgcgcga tctcgtcgat ctgggggtgc atcaggggtt cgccgccggc
     9121 gatcgacacc atgggcgccc cggactccag tacggcgccg acggcctgcg cgacgggcat
     9181 gcgctgcttg agcacaccgg ccggatgctg gatctttccg catccctcgc acttgaggtt
     9241 gcaggcgaag agcggttcca gttcgacgat gagcgggaac ttgtcccgcc tgcggagctt
     9301 ctgttcggcc aagtatgtag cgaccttgat ggactgacgc agcggcatgg ccatctggct
     9361 cacctcctgg ggagcagcaa ggaacggtgc cattcataga aagccgggag tacggaacga
     9421 aggacacgga aagccgatat tccaccgcgg accgtgccga tgcggacgag ttcgtgttca
     9481 ggagcgtcca cgaccacccg gacggccgca accgggcgct cggccgcgcg gacggcgctc
     9541 aggagcgtgg cggccgactc catgtccacc gcgatcgcgc cggtggcgag caggtcggag
     9601 cgttcgtggc cgtggacgac gtggtcggat ccggtgaggg ggccggtgtg gacggtgcgt
     9661 ccgggcaccg cgcgcatcag ctccttcacc agcagttcgg tgccgacgca cggcacggtg
     9721 ccgcgtgggt cccgggtctc ctcggcgacg accaggtcgc cggggtgcat gccgggggcg
     9781 aggcccgcgc agaagccggt ggcgaggacg gcggccccgt gcagcgccgg gtcggcgagc
     9841 acccgggtga cggaccgctc ggccgccgcc ggtcccatgc cggtgcgcag cacggtgacc
     9901 ggcccgcccg gggtggtgcg ctcccgcctg cgcagcgcga actgttcgat gccgagcgcg
     9961 caggcgatca gcagcggggc gggggcgggc cggccgttca tcagctgccc ttggcgtcgg
    10021 cgagcgcctg cgcggagccc gccggcacct cggccggctt cgcggcgaac ggctcgccgt
    10081 ggacgtaccg gccgagcgcg gtgagcggga acacctgccg gtagaggtgg tagttgatgg
    10141 agaagtccca cgggaagccg gtgccggtga agtacggctc gtcccaggag ccgtcctccc
    10201 gctgggtgtc cgccagccag gcgacgcccc gttcgaccgc ctcggagtcc cgctcccccg
    10261 ccgcgagcag cgccatcagc gcccaggcgg tctgggaggc ggtggaggcg cccttgccgc
    10321 tccactcctt gacgtagctg taggagcgca ggtcctcgcc ccagccgccg tcgtcgttct
    10381 gcaccttctc cagccaggcc acggcccgcc ggatcgccgg gtgggacgtg gggaggccgg
    10441 ccgcggtcag ggcggggacc acggagccgg tgccgtagat gtagttgacg ccccagcggc
    10501 cgaaccacga gccgtccagt tcctgttcgg cgaggagcca ctccacgccg cgccgggtgc
    10561 gcgggtcctg ggcgagccct tcgacggcga gcatctccac gacgtgcgcg gtgacgtcgg
    10621 ccgacggcgg gtcgatgacc tcgccgaagt cgcagaacgg cagccggttg gggaacgggc
    10681 tggtgttgtc gacgtcgaag gcgccccagg ctccgttcct cgactgcatg ccgaggttcc
    10741 agcgcacccc gcgcccgacg gcgttgtcca gccgctccgg gtcgtggtgt ctgacccggc
    10801 gcagcgcgag gaccacctcg gcggtgtcgt cgatgtcggg gtagttgtcg ttgtggaact
    10861 cgaacgccca gccgcccggc gggagatggg gccggcgcac ggaccagtcg ccgggccgca
    10921 ccacctgctc gcccagcatc cagtcggcgg ccttgaccag ggccgggtgg tcggcgggca
    10981 cgcccgcgtc ggccagcgcg atggtggcga ggcaggtgtc ccacaccggg gactggcagg
    11041 cctcgatcat ccgggcgccg tcctcgcgcc acagggcgaa gcggtccagg gagtccagac
    11101 cggcacgcat caccgggtgg ttcaggtcgt agccgagcag gtgcagggcg atgaccgagt
    11161 acacggcggg gggctggatg ccgccccagc agccgtcgtt ctcctgccgt tcgatgatcc
    11221 agcgggcggc ggtgttcatc gcggcccggc gcagccggcg cgggacggcc cggcgcagct
    11281 tgtgcaggcc cctgtcgagc cgctggaagg cgccgtccca ggtggtcgcg ggggcgagcg
    11341 gtcggggagg gttggggttc gccgggtcgg cgtgcagctc gtccagcggg aacggggctg
    11401 ggcgcaccgg ccgctcggcg gagacgatgg tgagcggcac gatggtctgc cgcgcccagc
    11461 agccgaagtc gtagatgttg agcggcaccc aggtggggaa ccagatcagc tcgggcggca
    11521 gttcgggcag gtcctgccac ttccaccagc cgaacagggc cagccagatg cgggtgaaga
    11581 cccgggacgc ggcgatgccg ccctgctccc ggatccaggc cgaggctttc gccatgtgct
    11641 cggcttcggg ggcgtcgccc gccagccgca gcgcgacgta cgcctcgacg gtggcggaga
    11701 gatcgccggg gccgccgaag aaggtggccc aggtgccgtc ctcgcgctgc tccccgcgga
    11761 tgaacagggc ggcggcccgg gtggtgtcct cgtcgcggat gccgaggaac tgacgcagca
    11821 gcaggtcctc ggcgtccatc gtgacgttgg tctcgaggtc gcccttccac cagccctcgt
    11881 cgctctgacg ggacagcagg aggtcggtgg cgcgccgtac ggcgcgggcg gcgatgtcgg
    11941 gtaccccggc cgccccgggg ctgtcggtgt cgtgttcgct ggccgcggtg agccgggacg
    12001 gcgaggccgc cccggtgctt ccgtcggtcg tcgctgtcat ggcttcccct tcgtgcagtc
    12061 ctgcaagtgg tgcatctgct gtgggtccgc cgtcggccgg tgggggtgct ccccaccggt
    12121 ccggcgacta cgcgagggct attcgaccga tagtgatcat ctctttcgta cgacgacgaa
    12181 gtccgcgagc gccgtgaact gttcccgcac ccggtcgggc atgtccacga cgtcgagggc
    12241 ctcgatggcg atggtgtgct ggcgtcgtgc ctcctcggcg gtccactcac ggccgccggc
    12301 ctcctcgatg agggcggcac gggccgcgaa ctcctcctcg gagaagttcg cgaagtcgct
    12361 gctcttggcg tcggcggcga ggatctcgcc gagccgggtg gcggccgggc cgtccgcggc
    12421 gagcgcggcc acgaccggga gggacttctt gcgctggcgc aggtcgctcc aggtctgctt
    12481 gccggtggac tccgggtcgc cccagatgcc gagcaggtcg tcgacggcct ggaaggcgag
    12541 gcccaggtgg tggccgtagc gctccagggc gtcggcggtg cgctcgtcgg cgccgccgag
    12601 gaccgcgccg atggagctgg cgcaggcgag cagggcgccg gtcttgttgc cctccatctc
    12661 caggcactcc tcgacgctga cccggtcgcg gtgctcgtag gagatgtcct gggcctggcc
    12721 gtcgatcagc gcgcggctgg cccgggtgag gcggcgtgtg gcgcggcccg cctcgacggt
    12781 gccgagctcc agcagcacct cgttggccag ggcgaacagg gcgtcaccga ccaggatggc
    12841 ctgggcggga ccgtgcacct tccagacggt gtcgcggtgc cggcgctgtt cgtcgccgtc
    12901 catcaggtcg tcgtgcagca gcgagaagtt gtggaccagc tcgacggcga ccgcgccggg
    12961 cacgccggtc tccccagccg cgccggtgac ctcggcggac agcacggcga gggcggggcg
    13021 cacggccttg ccgccgtcgc cgtccgcggg gcggccctgg gcgtcgatcc agccgaagtg
    13081 gtaggcggcg accgtgtcca tgggaggtgc caggcggtcg acggccgccc gcagtaccgg
    13141 cgtggccagg gtccggccgc gctccaggag cgcggacacg tccaccgcgg tccttcgagc
    13201 ggcctgcgag gccgggggca cagtgggcac agtctctcct cttgttgcgg taccgggggt
    13261 gcgggggctc gccgcgccgc tccgctgcag catcaggcgg cctcctcgag cgcgaagagg
    13321 tggcgcgggc ggggccggcc gagggcgccg agcgcggcgt ccgccgcgcc gacgccgctg
    13381 cggaccgcac tctccatggt cgcgggccac cccgtggcgg tccacgctcc ggccaggtag
    13441 aggccgggtg ccttggtgcg ggcgccgggc ctgaggcgtc cgacgccggg ggcgggaacg
    13501 aaggtcgcgg tgcgctcccg ggtgacgaag aagtcgagga cctcggcgcc gcgggcgcgc
    13561 ggcagcagcc gctccagttc gggcaggtac cgctcgcgca ggtcggccac gggcgcgtcg
    13621 atgtcgtcgt gggcgaccga ctgggacagc gccaggtact ggccgtggcg cagtccggaa
    13681 gcgtgggtgc ggtcgaagac ccactgcacg ggggtgccga gcgcggcgaa gaagggccgg
    13741 gtgagcaccg tgcggtcgta gacgacgtgc acgttgagga tgggggcggt gtcgatgccg
    13801 agcagccggt ccggggcgtc gagcgcgccc gcgggcagca ggtcgtacgc ctcgcgctgg
    13861 ggcacggcca ggacgacggc gtcggcgcgg agcgtctcgc cggggatgtc gacgctccag
    13921 ccgccgtccc cgtcggcgcg cacggagctg acgcgggtgc gggtcgcggt gcgtacgccg
    13981 gcggcgtcga gggcctcacg ggcgagccgg tcgtgcaggt cgccgagcgg cacacgggcc
    14041 cagccgatgt cggcggcgcc ggggtcggac agcaggccgg tcttgaacac catcgcggcg
    14101 agcgccagcg acgagtcgcc ggcgacggcg ttgagggtgg cgacgccgac caggtcccac
    14161 agtgcttcga cggcgcgcgg ggactggccg tgggcggcga gccagctgcc gaagtcctgc
    14221 tcgtccaggg cgggatcgtc gaggtcgagg cccttcagcg cgagggcggc acggcccacc
    14281 ctcgcccggt cggcgagcga caggtgggga tacgcggcga ggctgcggcc gaggtggaga
    14341 ggcaccggca gagggtcgcg ccgcagccgt cccagccgcc ggccctcggg gcgggccgcg
    14401 tcgaccacgg gcacgtcgag gcggtcctgc agcggggcga gaccggctcc cccgaggcgg
    14461 tcgaggaacc agcggtaggc ggtgcagcag cgcaggtaga cgtgctggcc gttgtcgacg
    14521 gtcaggtcgc cgcgcttgaa ggagaaggcg agtccgccca ggcggggccg cccttcgagc
    14581 agggtgacgc gcactccggc gtcggcgagg gcgagggcgg cggtggtgcc ggccagtccg
    14641 ccgccgacca cgacggcatg gcgtcccggc gggaccggac cgtccgtgtg cggggccccc
    14701 tcggagcgtg tgccgtggct catgcgccct cccccggcct gccgggcgcg acaggtgcgc
    14761 ggccggccgt ctcggtgagg gacgcgggga cgcggcggag ggttgcacgc cgctttccgt
    14821 tcgggtacgg ggagtccatc agtcgcgcct cccgacggtg cgccgggcga cgtgccgggt
    14881 gtcgagaccg gacaggccgc gcaccgccac gtacgccttt tcccgtccgg gcagggagac
    14941 ccggccgcgc agcacggcct cgggatcgcg ctcgatgcgg tccaggagac ggcggtagat
    15001 gccggccatg gcggcgacgc aggcgccgct gcgccggtcg agcatgggga gcagccggta
    15061 gccctcggcg aagagggcgc gggccctgcg cacctcgaag tgcaccaggc ccgcgaagtc
    15121 cgagccctgg ggcggtgtgg gtccggcgaa gccgtcggcg cagccgaact tggcgaggtc
    15181 gtcggccggc aggtaggtgc gcccgttctc ggcgtcctcg cggacgtcgc gcaggatgtt
    15241 ggtgagctgg agcgccaggc ccagcgtgtc ggcgtactcg gaggcgcgtt ccacaccgcg
    15301 cgcgccgggc tcggtgccga acacgccgag cgagagccgt ccgatggagc ccgcgacgca
    15361 gcggcagtag accttcaggt cgtcccaggt ctcgtacgtc tcgccgcgca ggtccatctg
    15421 gacgccgtcg atgagttcgt ccaggccgcc gagcgggatc gggaagtgcg ccgcggcgtg
    15481 ggagagggcg accgcgaccg ggtcggtgtc gtcctcctcg accgcgccct cgcggatccg
    15541 ggtgagcagc gcgcgggtgt cctcgagacg ggctgccttg acgtcctcgg ggagcggtcc
    15601 gtcgccgatg tcgtcgaccc gccgggagaa cgcgtacagg gccgacatgg cgcgccgctt
    15661 gggcgtcggc agcagccgga tgccgtaggc gaagttgcgt gcctgctggc cggtgacggt
    15721 ctcgcagtag ctgtaggcgg cgagtaccgg tgcggacgcg gatggctggg actccacggt
    15781 ccggatcacc cctttcctcg cagagtcacg cccgcctcgc gcagcagctg cagcgtgccg
    15841 ggcttgggcg ggccgggaag tacgtcgtgg tcggcggccg cgatcgcgcg gacggccgcc
    15901 cttcctcccg ccacgaaccc cgcgagcagg agtctgagcc ggccccggac gctgcccacc
    15961 aggggtgcgc cctcgtccag caggtcgagg gcgcgctgcg cctggaacgc gacgagcgcg
    16021 cgcaccgagg cgccggcggt gggctcggcg aggtcggcct cctgcacgtg gaaacgtttc
    16081 atgtccgcgg cgggcacgta gatgcggtcg cggccgaggt cctcggcgac gtcctgaagg
    16141 tgctcgacga tctgcagggc ggtgcagatc gcgtcggagc ggcggatgcg ctccggtgtg
    16201 gcggtcccgg tggcggcgag cacgaggcgg ccgaccgggt tggccgacag ctcgcagtag
    16261 gcgagcaggt cgtcgtaggt ctcgtagcgc gtgacgagct ggtcctggcg gttcgcggcg
    16321 atcagcccga ggaacggctc gggggtcagc gcgcggcggc ggaccgtgcg ctccaggcgg
    16381 agcagcaggg ggtgacgggg cgccgggccc gtcgggtcga acacgcggtg aagatcggct
    16441 tccagggcgt ccagcagggt gaggcggtcg ccggccttgt cctcggggac gccgagggcg
    16501 cgggcgtcgg ccccgccggg ggcgaggtcg ccgtcgccga tgtcgtcgac cagacgggcg
    16561 aagccgtaga cggccatgag gtcgtcgcgc caggccctgg gcaggaagaa gggcgccacc
    16621 gggaagttct cggcggcggc cttgtcgagg gtggcccgtt cgaggtcgcc ggggcgcgcc
    16681 cggccggcgg cggtcatcgc ggactgcccg gggagaggac ggcgcatgct gagttcagcc
    16741 ggggagtctc cgaagccatt gccgtcacat ctcccgttct acactgctga cccaattcac
    16801 actatttcgg acacgccgcc caggcgtcca cccgacggcg ccgaggaatg gtgtcgggca
    16861 ttatggccct gattgccgcc tttcgcggac cggtacagct tacgttgtac aacgcgccgt
    16921 tcctcgacgg gggtcttccg tgctccacga caacacatcg tccggcgtca ggcttccgcc
    16981 gtgcgcgggg agttgacgca tcttttgcag acgcgggacc ccgccggacc gttccggcgg
    17041 ggccttgggc gaaacgggct acttgccggt gaacttctcg tactcgcgga gcacctcgtc
    17101 cgtcggcccg tccatgcgca gctcgccgcg ctccagccac agcacccggt cgcaggtgtc
    17161 gcggatggac ttgttgttgt ggctgaccag gaacaccgtc ccggcctcct tgcgcagctc
    17221 gcggatgcgg gcctcggagc gcttctggaa cttccggtcg ccggtggcca gcgcctcgtc
    17281 gatcatcagg acgtcgtggt ccttggcggc ggcgatggag aagcgcaggc gggcggccat
    17341 gccggaggag taggtgcgca tcggcagggt gatgaagtcg cccttctcgt tgatcccgga
    17401 gaagtcgacg atgtcctggt agcgctcctt gatctcctcg cgggacatgc ccatcgcgag
    17461 cccgccgagg atgatgttcc gctcgccggt gaggtcgttc atcagggccg cgttcacgcc
    17521 gagcagggac ggctggccgt cggtgtagac cttgccgcgc tcggcgggca gcagtccggc
    17581 gatggcgcgc agcagggtcg acttgccgga gccgttggac ccgatcaggc cgatggcctc
    17641 gccgcggtag gccacgaagg acaccccgcg cacggcgtgc accttgcgca cgccccgctc
    17701 ctcgccgcgc ttgaggatcc ggctgagcgc cgcggtggcg ctgcccttgc ccgaccgggt
    17761 gccgttcacg cggtagacga tgtgcaggtc gtccgcgatg acggtgggca cccgggcgcc
    17821 cgtcttgtcg tcagccacgg ccgtacctct cctctgcctt ccagaagtag acgaagccga
    17881 ccacgccggc gagcaccgcc cagcccagcc cgaacgccca gatgtgcggc ggcaggtagg
    17941 tcgagtcgta cttgtcgatc agcgcgtatc gcaccaggtc catgtagacc gcggccgggt
    18001 tccactggag tacgtccgcc acccaggacg gcacgttctt gtcctccagc atggccggga
    18061 tggagaacat cacgccggac gcgtacatcc aggtccgcag cacgaacggc atcagctgcg
    18121 ccaggtcggg ggtcttgctg cccatccgcg cgaagatcag cgcgaggccg gtgttgaaga
    18181 cgaactgcag ccccagtgcc ggcaccacca gcagccacga caggtccgga tagctccgga
    18241 acgccaccat gatgacgacc aggacgatca tcgagaagag cagctgctgg agctgctgga
    18301 gcgcgaacga gatcggcagc gacgcccgcg ggaagtgcag cgcccgcacc aaccccaggt
    18361 tccccgagat cgcccggaca ccggccagca ccgagctctg cgtgaaggtg aacacgaaca
    18421 cgcccgtcac gaggaacggc acgtagacgt cgctcgggat gccgcgccgg gccccgagca
    18481 gcaggccgaa gatgaagaag tacacggccg cgttcagcag cggcgtcgcg acctgccaga
    18541 gctgccccag cttcgccttg ctgtactggg cggtcagctt ggcctgcgag aaggccagga
    18601 tgaagtgccg ccgtccccac agctgacgga cgtactcgcc gagggacggg cgggcgccgc
    18661 tgacggacag cccgtacttc gcggccagct cggccgccgg aaggccctcg tcgggcgaca
    18721 cgggcgcgcc gaccgcgacc gtgccgtcgt gcgtagtctc actcacgggt ggattaactt
    18781 tcgtcctcga tgtgcggggc ccgcgcgggc ctgccaggag ccggggagcg ggtaggggcc
    18841 ggatccccgg actcgaagct tgtcagatca ccgggggccg gcccagtcgg gtcagccgcc
    18901 acaccgtacg ccacttcatg gggcgacggg gcccgcaggg cgaggtccag ccctccttga
    18961 agccgccgaa ccacgccttg agggcggagc ccgaggggcg gcgcaggagg gtgaggagca
    19021 gccagacgcc caggtacacc gggacgagcg gggcgggcag gttgcgccgg gcgagccaga
    19081 cgcggttgcg ggccaccatg cggtggtaca ccgcgtgccg cgagggggcg gtcgtcgggt
    19141 ggtacagcac catgtccgac cggtagtcga tcatccagcc ggcgtcgagg gcacgccagg
    19201 ccaggtcggt ctcctcgtgg gcgtagaaga actcgtccgg cagtccgccg acctccgcga
    19261 ggacctgggt gcgcaccgcg ttggcaccgc cgaggaacgt ggtcacgcgg gaggagcgca
    19321 tcgggtcgga ggcacgcagc cggggcacgt gccggcgctg ggtgacgccg gtgtccggat
    19381 cggcgatgcg gaagctgatg atgccgagcg aggggtcctc ggcgaacgcc ttccggcaca
    19441 gctcggcggt gtcggtgtgc gcgagcaggc cgtcgtcgtc gaggaagagc aggatgtcga
    19501 cgtcccggcc gctgggcccg aaggcctcga tgccgacgtt gcgcccgccg ggaatgccca
    19561 ggttctcggg cagctcgacg gtcttgacgc cctcggggac gtcgggcacg ggcgagccgt
    19621 tgccgacgac cacgacctcg acggggtcgc cgtcctgttt ggcgacggag tcgagcaggg
    19681 cccgcagttc gtcggggcgg ttgcccatgg tgatgaccac cgcgccgacc ttcatgcccg
    19741 cgttcacttc agcctgctcg agacgaggac ggacacgagg tgcagcagcg tctgcagcag
    19801 ggcgatgccc gcgaggacgg cggtgccgag gcgggtgaag aacaggtcgc cccgggcgga
    19861 gtcgaggatc gcgaggagca ggatcagcag ggacgcctct atgcccagga tcagccggtg
    19921 gaacttcagg gcggcggcgg ccttgcgggc gagcgccatg ccggaggagc gcggctcgga
    19981 ggcggactcc ttcaccgggg gcatgccgtt ctggtggcgg gcgacaccga ccaggtcggt
    20041 ctccgccttg atgagtatcg cgcccagcgc ggcgagggtc ccgaggaagg cccacagcca
    20101 gtcgatgcgg ccggtgcccc acaggtcggc ggcgcgcagg ccgaggccga ccagcacggc
    20161 ggcgtcggtc aggtaggcgc cgacgcggtc catgtagacg ccggcgaggg agtactgctt
    20221 gcgccagcgg gcgatctcgc cgtcgacgca gtcgagcagc aggtacagct ggaccgcgac
    20281 caccccgagg accgcccccg tgatgccggg caccaggagc gcgggggccg cgaggacacc
    20341 gcagagggtc atcagatacg tgagctggtt gggggtgacc cgggtgttca ccaggtagcg
    20401 gtcgacccgc agggacacct cgcgcatgta gaggcgtccc atccagtgct caccgctgcg
    20461 ccggtccttg acccccgcgg ggtgcacgac cggacggagt tcagctaccg atggccttga
    20521 catagtcggc gtagacgtcc ttgatctgtt cggtggtcag ggcgaggtgt tcgaggatgg
    20581 tgaagcggcc ggggcgggtc tcgggggcgt actcgacgac gcggacgaac tcgtcgacgg
    20641 agaacccgat ctcctcgggg agcaccggca gcccgtgccg gcgcagcacc tcggccatgg
    20701 ccgccgactc ctcgtgcgcg ccgcgcaggt acatcgcgaa ggcggcgccc agtccgcact
    20761 gctcgccgtg ggcggcggcg cgctgcgggt agagcaggtc gaaggcgtgg ttgatctcgt
    20821 ggcaggcgcc ggaggagggc cgggagtcgc cggacacgga catcgagatg ccggtgagca
    20881 ccagggcctc ggcgagcacc tggaggaagc tgtcgtcgtc gacgccgccc gggtgccgga
    20941 gcacggcctc gccggcctgg cgggccatgg ctgcggcgag tccgtcgacc ttctcgccgt
    21001 tgacgcggtg ggacagctcc cagtcggcga cggcggagat gttcgagacg acgtcgccga
    21061 tgcccgagcg gacgaaccgg accggggcct cgcggatgac gttgaggtcg atcacgaccg
    21121 cgatcgggtt gggcacgccg taggagccgc gtcccgcgtc gttgtcgagg gtggcgaccg
    21181 gcgagcacag gccgtcgtgc gccaggttgg tggcgaccgc gaccaggggc aggccgacgc
    21241 gcgccgaggc gaacttggcg cagtcgatga tcttcccgcc gccgaggccg acgaccgcgt
    21301 cgtaacggcc gccctggatg gcgccggcca gccggaccgc gtcgtcgatg gtgccgccgc
    21361 cgacctcgaa ccagtcggcg ccgggcagcg acggcgcgac gcggtcgcgc agccgggcgc
    21421 cggagccgcc gctgacggcg atggcgagcc ggccggactg cgagatgcgc tcgtccgcga
    21481 ggacgcaggc caggtcgtcg agggcgccgg ggcggatgtc gacgacgacc ggcgtgcgcc
    21541 cgcgccgctc agcgaccggc gacgatctcc cgtccgcggg cgaggtcgtc gtggttgtcg
    21601 atctcgaccc accggacgtc gccgatcggc gccacgtcga tccggaagcc ccggttcacc
    21661 agctcctggt agccgtcctc gtagtacagc tgcgggtccc gctcgaacgt cgccttcagc
    21721 gcgtccgcca gggcctcggc cgcaccgccc tcgatcagcg tcacaccgat gtactcgccc
    21781 gtcgcctccg ccgggtccat cagcttcgtg atccgccgca tccccttctc cgggtcgacg
    21841 acgaccttca tctcctcgtc ggcgagccgc ttcaccgtgt ccagcgccag gatgatctgc
    21901 ctgccgtcac cccgcgcgtc cagcagcgtc cgctccaccg acaccggatg caccgtgtca
    21961 ccgttggcga ggatcacacc gtccttcagg gcgtcccgcg cacaccacag cgagtaggcg
    22021 ttgttccact cctccgcctt gtcgttgtcg atgagcgtca gcttcagccc gtacttcgcc
    22081 tccagcgccg cctgccgctc gtacacggcc tccttgcggt agccgaccac gacacccacc
    22141 tcggtcagcc cgatctccgc gaagttgccg agcgtcaggt ccaggacggt cacggcgtcc
    22201 gggtcgccct ccgcgcccac cggcaccagg gccttgggga gcgtgtcggt gtacgggcgc
    22261 agacgccggc cggcgccggc cgcgagcacg aggcctatca tcgcggtcgt tctccttcag
    22321 ggactggaaa agcgtgtggc cctgccccgc agggggacag gaccacacag cgtagacgct
    22381 ggtcagctct cgtcggccgc ggccgtgacg gaggagggcg cctgctgctc cgcagcggcc
    22441 gtcttcttcg tcgtggcctt cttcgccgtc gacttcttgg cggtggtctt cttcgccgcc
    22501 gtcgtcgtct tcttggctgc cgtcttcttg gccgtcgtcg tcttcttcgt ggcggccttc
    22561 ttcgccgtgg ccttcttggc cgtcttgcgg gcggccttct tggccggagc ggcctcctcg
    22621 gcaccctcgg caccctcgac gggctcggcg gcctccggct cggcggcggg ctcctcggcg
    22681 cgcttctgct cgtccgccgg gacggacggc aggaccacga cggccgtgtc ctcggacgcg
    22741 gtcgaggtgc tcggcttgcg caccgcgcga cgccgcggcc gggccgggga ggacgcctcg
    22801 ggcgcggcct ccgggacggc ggcctcggcc ggggtctcct cggccttcgg cgcctcctcc
    22861 gtcctcgcgg actcggcgac ggtcaccacc gcggcctcgg cgcccgccgg ggaaccggcc
    22921 ggcgcggtcg ccttgcgggt ggcccggcgg cgggtgcggc ccttcggagc ggcctcctcg
    22981 gcctgcggca ccacgacgtc ctcggcggcg gccggctcgg ccagcgcctc ggcggccgac
    23041 tcgggctgca cgggacgccg cgcctcctcg gtggccgtca cgtcctgcgc cgtggggacg
    23101 gcccgcgtct cctcggcggc gggcgcctcc tcggcgcgct cctcggcctg cttgcggccg
    23161 cccttggcgc tctcacgctg cggggagccc gcgggcgcgg aggcccgacg gctcgcccgg
    23221 cggcgcgtac ggccccggga cgcggcggcc tccgcctcgg cggcgctgct gtacagctcc
    23281 tcgtccggcg tgaactcggg cgacggcagc gcggccggct cggccgcctc ggcggcgacc
    23341 tcggccggcg tctccgactc ggcctcggcc tcctgctcgg gcgtctccac ggcggcctcg
    23401 tgctcgtgcg gctggtccgc cgcaccggcc cgggcgcgct tgcggcgctt gccgccgccg
    23461 gagaaggacg gctggtcgag gtggacgatg acaccacggc cgttgcagtg gacgcaggtc
    23521 tcggagaacg actccagcag gccctggccg acccgcttgc gggtcatctg gaccaggccc
    23581 agcgaggtca cctcggcgac ctggtgcttg gtgcggtccc ggcccaggca ctccagcaga
    23641 cggcgcagca ccaggtcccg gttggactcc agcaccatgt cgatgaagtc gatgacgatg
    23701 atgccgccga ggtcgcgcag ccgcagctgg cgcacgatct cctcggccgc ctccaggttg
    23761 ttcctggtga ccgtctcctc gaggttgccg ccctgaccgg tgaacttgcc ggtgttgacg
    23821 tcgatgacga ccatcgcctc ggtccggtcg atcaccagcg aaccgccgct gggcagccag
    23881 accttgcggt ccagcgcctt ggcgagctgc tcgtcgatcc ggtacgtggc gaagacgtcg
    23941 acctcgctgg tccaccgctg cagacggtcg gccaggtcgg gcgcgacgtg ggagacgtag
    24001 ccgtggacgg tcccccaggc ctcgtcaccg ctgacgatga ccttggagaa gtcctcgttg
    24061 aagatgtccc ggacgacgcg gacggtcatg tccggctcgc cgtacagcag cgtcggggcg
    24121 gtgccgccgt tcttggactt cttcttgatc tcctcccact gcgcctggag acgctcgacg
    24181 tcacggcgca gctcgtcctc gctcgcgccc tcggcggcgg tgcgcacgat gacgcccgcg
    24241 tcctcgggga cgatcttctt gaggatggtc ttcagccggg accgctcggt gtcgggcagc
    24301 ttgcggctga tgccggtcat cgaaccctcg ggcacgtaca cgaggtagcg gcccgggagg
    24361 gagacctggc tggtgaggcg ggcgcccttg tggccgatcg ggtccttggt gacctggacc
    24421 agcaccggct gcccggactt cagcgcggac tcgatgcggc gcggaccgcc ggacatgccg
    24481 agcgcgtcga agttgacctc gccggcgtag agcacggcgt tgcggccctt gccgatgtcg
    24541 atgaaggcgg cctccatcga cggcagcacg ttctgcacct tgcccaggta cacgttgccg
    24601 acgtacgagg tggcctgctc cttgttgacg tagtgctcga cgagcacgcc gtcctccagg
    24661 acgccgatct gcgtgcggtc gccgtgctgg cggaccacca tcacgcgctc gacggcctcg
    24721 cggcgggcca ggaactcggc ctcggtgatg atcggcacgc gccggcggcc ctgctcgcgg
    24781 ccctcgcggc ggcgctgctt cttggcctcc agacgggtcg agcccttgat ggactgcacc
    24841 tcgtcggacg gctcggcacc cttttcccgc gggggacggg gctcgcggac cttgacgacg
    24901 gtgcgctcgg ggtcgtcggc ggacggctcg ggctcaccgc cgctgtcccc ggcgcggcga
    24961 cgacggcgac gacggcgacg gctgctgctg gagccgccgt tgtcgtcggt ctcctcgcgc
    25021 tcctcggcgt cctcgtcgct ctgtccgtcg gtgtcctcgg cgtcccgcgc ggactgctcg
    25081 gtcccggccc gctctgcggc ttcggtgtcg tcgtcctgct gctcgccgct gtcggcgtcg
    25141 gcggactcgc cacggcggcg acgacggccg ccacggcgac ggcggcggcg cgaaccggac
    25201 gactcctggt cgtcgtggtc gtcgccctcg tcgctgtcgg cccggtcctc ggcctgatcg
    25261 ggggcttcct cggcgttggc ctcggaggtc tcctcggcgg cggccggcgc ggcggcctcg
    25321 ggctcgtcgg aggcgccctt gcggcgacgg cgacggcggg aggcggcggg ctgctcctcc
    25381 gggagctcct cggtctcctc ctccggctcc gcgctctcgg cgactccggc ggcggcctcg
    25441 gcggcggccc gctccggggt ctggaagcgg ggctcggtga acaccggcgg ctggaacacg
    25501 gcgacggcgg gacgcgcggg acggcgcggg gcgtcgtcct tgtcctcggc ctcggcgccg
    25561 cgggcggagc gcgcgggctc ggcgaacccg gcggcggcct tgcggacgac gcgccggcgg
    25621 cggcgcgggc cgccctcctc ggcgggggcc tgcgcagcgg gcgcctcggc gggggtctcg
    25681 tcctgcttgt cgttctccgt caccggggcc tcctcggtgg tcggggcggc ctgctcggtc
    25741 tcgtcgtcgc ccagtgcggc gacggcctcc gccgtcgctt cggcggcggg agcaccggcg
    25801 ggcgcggacg cgcgccgaga ggcacggcgg cgggagcggc gcggggcggc gtcctcggcg
    25861 acgtcggctg cgggctcggc ggccgtgccg gcggcggccg gggcggtctc ttccgcagcg
    25921 ggctcctccg cctccggctc ggcgggggtc tcggccgcgg tctcggccgc cggggcggtc
    25981 acggtgcgcg cggcacggcg ccgggtgcgg cgcggagcag cgtcctccgt cgcggcggcg
    26041 gccggctcgg ccggggtctc ggtgttcccg ggggccgcgg cggtctcgtc gacggccccg
    26101 gtgtcggcag ccggcgccgg agcggtcacg gtgcgcgtgg cacggcgccg ggtgcggcgc
    26161 ggagcagcgt cctccgtggt gtcggcggcc ggctcggccg aggtctcggc gctctcgggc
    26221 gctgcggcgg tctcgtccgc ggccccggtg tcggcggccg acgccggagc ggtcacggtg
    26281 cgcgtggcac ggcgccgggt gcggcgcgga gcagcgtcct ccgtggtgtc ggcggccggc
    26341 tcgggcgccg gggaggcggc ctcggacgcg ggctgcgccg cggggacgac ggtctcggcg
    26401 gcctccgctg acgccggtgc tccggcgggc gcggccgcgc ggcggaccac acggcgacgc
    26461 cgggccgcgg gggccccggt ctcctcctgg gtgtcggtcg cgccctcggc gggcaggggc
    26521 gtctccgccg gttcggcggg cgcctccgcg gccggtatgg ccgacgtgac ggtctccgcc
    26581 gtgctgcctt cggcggcggc gggcgggccc gccgcggccg caggccccgc ggagcacggc
    26641 ggcggggaag ccggggccgg cgtcggcgac ctcgatgcgg cacttctcgc cgtccag
//
