LOCUS       NZ_RAII01000001        22934 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2934595
            Orig. end                         :: 2957529
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22934
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="11"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22934
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22934
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12934](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12934)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            202..690
                     /locus_tag="EBH12_RS13675"
     CDS             202..690
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975371.1"
                     /locus_tag="EBH12_RS13675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phage holin family protein"
                     /protein_id="WP_048456981.1"
                     /transl_table=11
                     /translation="MSAPDGSPVGAERSIGQLFATATAEMSALVHDEIALAKAQLRQDV
                     KRGATSGGAFMAAGVLLLFSLPMLNFALAYGIRTWSGWNLAVCFLLSFAANCLVAGLLA
                     LIGVVFAKKAKKGRGPQKVAASVKETAGVLQKAKPHPRPALPAHRGPEAIEAVARSSS"
     gene            687..1637
                     /locus_tag="EBH12_RS13680"
     CDS             687..1637
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (45-298). E-value:
                     9.9e-27. Score: 86.0. Matches aSDomain:
                     nrpspksdomains_EBH12_RS13680_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134538.1"
                     /locus_tag="EBH12_RS13680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_114873987.1"
                     /sec_met_domain="PF00561 (E-value: 7.2e-20, bitscore: 70.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5e-22, bitscore:
                     78.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDPATPSAQPASVVRLDLPDAPGLVHRDVAANGARFHIAELGDG
                     PLVLLLHGFPQFWWTWRHQLTALADAGFRAVAMDLRGVGGSDRTPRGYDPANLALDITG
                     VIRSLGEPDAALVGHDLGGYLAWTAAAMRPKLVRRLAVSSMPHPRRWRSSMLADARQTA
                     AQSHIWGFQRPWIPERRLTADDGAMVARLVQEWSGPQPPDEKVLETYRRAMCIPSTAHC
                     SIEPYRWMVRSLARPDGIQFNRRMKRPVRVPTLHLHGSLDPVVRTRSAAGSGQYVEAPY
                     RWRLFDGLGHFPHEEDPVAFSTELINWLKDPEPDR"
     aSDomain        822..1580
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS13680_Abhydrolase_1.1"
                     /evalue="9.90E-27"
                     /label="EBH12_RS13680_Abhydrolase_1.1"
                     /locus_tag="EBH12_RS13680"
                     /protein_end="298"
                     /protein_start="45"
                     /score="86.0"
                     /tool="antismash"
                     /translation="PLVLLLHGFPQFWWTWRHQLTALADAGFRAVAMDLRGVGGSDRTP
                     RGYDPANLALDITGVIRSLGEPDAALVGHDLGGYLAWTAAAMRPKLVRRLAVSSMPHPR
                     RWRSSMLADARQTAAQSHIWGFQRPWIPERRLTADDGAMVARLVQEWSGPQPPDEKVLE
                     TYRRAMCIPSTAHCSIEPYRWMVRSLARPDGIQFNRRMKRPVRVPTLHLHGSLDPVVRT
                     RSAAGSGQYVEAPYRWRLFDGLGHFPHEEDP"
     gene            1738..1920
                     /locus_tag="EBH12_RS36405"
     CDS             1738..1920
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015658867.1"
                     /locus_tag="EBH12_RS36405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_078492825.1"
                     /transl_table=11
                     /translation="MGWTHDYSDASRNRRSASGVGSHQRGGAPQMAATDLRVGIPRILR
                     RRARWVSVRLRHPRG"
     gene            complement(1967..3166)
                     /locus_tag="EBH12_RS13690"
     CDS             complement(1967..3166)
                     /EC_number="3.4.21.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825250.1"
                     /locus_tag="EBH12_RS13690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarP family serine protease"
                     /protein_id="WP_114873988.1"
                     /transl_table=11
                     /translation="MNVLDILLLVAAVWFAVVGYRQGFVVGILSVVGFLGGGLIAVYTL
                     PVIWDAMTDNSEVGTTAAVVAVVVVIVCASVGQALTTHLGNKLRRYITWSPARALDATG
                     GALVNVVAMLLVAWLIGSALAGTTLPTLGKEVRGSKVLLGVSRALPDQADIWFADFSSV
                     LAQNGFPQVFSPFANEPITDVRPPDPALAGSPVAARAQRSIVKVTGTATSCGKVLEGTG
                     FVFDDRRVMTNAHVVGGVDEPVVQIGGEGRTYDATVVLYDWKRDIAVLDVPDMDAPALR
                     FATEDAGGGDSAIVAGFPENGAYDVRAARLRGRITANGPDIYHRGTVRRDVYSLFATVR
                     QGNSGGPLLTPEGEVYGVIFAKSLDDAQTGYALTVDEIREDIARGRSAAQEVDSDKCAL
                     "
     gene            complement(3212..3955)
                     /locus_tag="EBH12_RS13695"
     CDS             complement(3212..3955)
                     /EC_number="3.6.1.55"
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003986 - acetyl-CoA hydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008413 - 8-oxo-7,8-dihydroguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_function="GO:0010945 - coenzyme A diphosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0035539 - 8-oxo-7,8-dihydrodeoxyguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0015938 - coenzyme A catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132550.1"
                     /locus_tag="EBH12_RS13695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CoA pyrophosphatase"
                     /protein_id="WP_121740710.1"
                     /transl_table=11
                     /translation="MTGVSDIRVTSGTQGGPVALSRDGLPAWLSPVVRAAETVRPTQLS
                     RFLPPADGSGRQSAVLILFGDGTRAVERCEEDGRGPQLLLMERASSLRSHAGQPSFPGG
                     ALDPEDGDPQGEGPLRAALREAEEETGLDPSGVQLFGVLPRLYIPVSGFVVTPVLGWWR
                     EPTPVGVVDPNETARVFTVPVADLTHPDNRATAIHPSGFHGPAFLVESALVWGFTAGVI
                     DRLLHFAGWERPWDRDKQVPLDWRA"
     misc_feature    complement(3927..3942)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            4140..5249
                     /locus_tag="EBH12_RS13700"
     CDS             4140..5249
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138882.1"
                     /locus_tag="EBH12_RS13700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_241563143.1"
                     /sec_met_domain="p450 (E-value: 3.2e-20, bitscore: 71.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRNDLTGYDEVMRCLRDRAVSADRVRPLMDAVPQGAREDAERAF
                     SILSRWMVFNDPPQHRRLRQVFQEAFAARAVARYSAFTEKVTRAVLTRKAAPGHSGDLM
                     SDVAKPLPALVFARWLGIPPTDGPSFWYWNARVADLVLGTAQEESEYRASLQALVSLED
                     YLGALVERRRAEPGDDLISQVLAEGRVGDTVSEQEFVGMLTQMAFAGGETTSNLIANTV
                     LALHTRPGQLAAVRDEPDLAQGAVEETLRLDGPSKMSIRTAAQDLELGGHTLRAGDRVF
                     LVTAAANRDPARFPDPGRFDVTRSGATHLGFGFGAHFCIGAALARLVAVCAVRTLVCER
                     PGLALADPARLSWQPSLLNRSLTALPVHY"
     gene            5286..6533
                     /locus_tag="EBH12_RS13705"
     CDS             5286..6533
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827427.1"
                     /locus_tag="EBH12_RS13705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_114872595.1"
                     /transl_table=11
                     /translation="MATTLAADRPRLWEPARHRSFRLLWTGQALSLLGDGFSVVAFSWI
                     TLSLTGSTLTLGYVLAFQAVPRALLTLVGGTLGDTWSTRTLMVASSWTRSALMAAVGIA
                     GLTGHLTVWMLCAAAAAFGAVDAFFQPARVSILPSVVDKELLAPANALLGAGARTAAVL
                     GPAVGGTVIALTQAPVAFLVDAVCFALCGLCVARIRTRPRTDAPKAAPEEKGPSLGARI
                     REGVTFTLRDPRLRTIVALDTAVNFCYAGPFTVGFATLADQVLRGGSATLGVLNGALAG
                     GAVLGTLVGGAVGGRPRVGLLVAGLAGWLGAGMAVLGLAQNTPVVIATVLAMGFAIGYQ
                     GVFGLSWIQRNIPQDVLTRVVSVDMVLGYAAAPLSLILCGALAGTGHLALFGVVAAVLA
                     VTGLAVLGSRAVREMR"
     gene            complement(6551..9466)
                     /locus_tag="EBH12_RS13710"
     CDS             complement(6551..9466)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827428.1"
                     /locus_tag="EBH12_RS13710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_121740372.1"
                     /transl_table=11
                     /translation="MRSHTPYLIGRDLQLTQLERSLADARQGMGSVVFLVGEAGVGKSR
                     LAAEAVGQAVSSGMRVLRGRSSTTGPAVPFRPLTEALMSLFRGGDPMDDLALGPYRAVL
                     GRLIPDWDTGERDGSSMVILGEAVLRLLIAAGRGQGQLLLLEDLHDADPETLGVLEYLV
                     DNLACTPVLLVATVRTDISDALDLAQSARRRGAATVVELPPLSRPQVHEVIAAQLGVDS
                     PGDVPAEVLDRLWEDSAGSPYLVEELLQSMIGSGTLVQGPGGWRAVGDLRRDVPSTLAR
                     GILRRIDRLGAQGLTLMSAAAVLGRRFPLSVLQRVTGVDDRTLLGHLHAGVAARLVVPD
                     EPAPDWYSFRHSPTLKALFTHMTPGRRAELARRGAQAVEELHPALEGDWCALAAGLRCE
                     AGDRVEAGLLYADAGGRALAAGALNSAVTLLSRAESLLAEGGDPQARAAALENLLPALA
                     EAGDFARAFDLVDDLHALGGEGLSPVRLATLHARLAKVAHTAGRWSDGNRQVLRAREVL
                     ASTPDEATEAAVDVTAAYLALDTPGPDRTQHAEKLARSAADTAERHGLPIVACQAWELL
                     ATVARERDPQESEAMLGQAMSAAERHRLPLQRMYAATRMGGNAWLAEGDTGGLLSAREE
                     ALRLGSVNIVHTVDGILVLDAVLRGRDDVARCTAAECLAVVRRLRLAPAVRYVVMAQAT
                     LEAHRGDRQAMEATLAAFTEWDGAGSQEEPLTRGLAGAFCALLEENRELAREELAAVQA
                     MEADNPSTYHLGGTHGLGLLLDVLEGEADRARHAEITATAMARMRWNRQFVHLAEAVLL
                     GREGAGADAAAAVERALAAAEPYPLAQHLGLRLIADAAHQDGWGDPVSWLRRAEHHFHE
                     RDIAAVTGACRAGLRRLGAPVHQHRSGTSGIPEQLRTQGVTVREFDVFRLLAERLSNKD
                     IADRLFISPRTAEKHIASLITKTGAANRADLCARSAALRSG"
     gene            complement(9651..9866)
                     /locus_tag="EBH12_RS13715"
     CDS             complement(9651..9866)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991555.1"
                     /locus_tag="EBH12_RS13715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048460598.1"
                     /transl_table=11
                     /translation="MDQHLAATDSAEFTAVESAETAHTEQDVVGGITLSGRNRACARAR
                     VLAGMVLTSGIVITLSSLDTSVSAPN"
     misc_feature    complement(9951..9966)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(10001..12934)
                     /locus_tag="EBH12_RS13720"
     CDS             complement(10001..12934)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EBH12_RS13720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_241563144.1"
                     /sec_met_domain="DUF4135 (E-value: 2.2e-95, bitscore:
                     318.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.5e-21, bitscore:
                     75.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGATAAALAAEPAERLAERAVEPDWASYAEQVLAHASEGLPEVE
                     VGGEGPDAFAPAVRPLVAMAAARLADRTAGVPDAEATVWRDAFTCRLTHQLVRLAARTL
                     AQELHRARRSRRLAGAGPRERFASFVAAAGTRRGLSDLFTAYPVLARMLSRTALDATEA
                     TAELVARFRSDRADLVAALLDGRTPGRLVRVDLGRGDAHQGNRSVAILHFADGRRLVHK
                     PRPLDQHALLDDLVSWLNAKVPGLGLRTPRTLRRESHGWLEFVEHRWCSSVTETDTFYR
                     RQGALLALLYAVDGADMHYENVIAYGDQPVLVDAETLLHTGLGQALTAGADPAADALAA
                     SVHRTCLLPHLLIGEHGALDISALGRDTDGTFPGEGLRWEDSGLDTMRAVRGPLASPAA
                     QNHPLPHGTSLSVTDHRAALLEGFRVAYAAIVAHRGELVGQDGPLTRWGDRPARLIARA
                     TRLYATLLEESTHPALLGNALAREGVFAVLWSESAQDPARERLTEHETAALWRGDVPFF
                     THRPTGTAVIADDGARVPDLLPVAAVTAVREKIGRMDEVDCLDQEWVISATLAVRGASS
                     PPDRPRSELAPALMPPVAPDPSRLLAAACGIADEIAARAVRGGARTNWIGLERVSGDHW
                     AVLPMGAGLAQGYCGVALFLAHTEALTGSGRYGAAAREAVRPLPALLKALAEDPELSEA
                     AGPGAYDGLGGIVYALVRLAGLLDEGLRACMPDALTALGHAAVACADSGLAQGRAGALA
                     ASVAAYEATGDPAALRLADQVADLLPQALGEGPVTRAVVGSGLPSSAGFADGAAGIAWA
                     LRRYAGHRPERAARAECTAVALLDSGAQHGDPADLSWSHGLAGRAVAGLPNPVEPPDDA
                     SLFEASVRLADAPIGPDLSLAQGVLGRLEALTVLAEQGDSTARSALRRHTGHVLALVEA
                     QGHRCATPDHVPSPGLLTGLAGIGYGLLRLAHPGTVPSVLLLHHPDH"
     gene            complement(13358..13753)
                     /locus_tag="EBH12_RS13725"
     CDS             complement(13358..13753)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527830.1"
                     /locus_tag="EBH12_RS13725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048460811.1"
                     /transl_table=11
                     /translation="MTTQQETRPSAATKPVRWAADAVAAMREGARLRLDYSARSLWSVD
                     RMIEDIRRESAPYAAVELVLRGFGAYAGEVIVRQAGAEWWASGGDHWVRTPDGRLWDPI
                     DEARRCYTQDGSLRLLCRDATTGARPD"
     gene            complement(13903..14481)
                     /locus_tag="EBH12_RS13730"
     CDS             complement(13903..14481)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527831.1"
                     /locus_tag="EBH12_RS13730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048460812.1"
                     /transl_table=11
                     /translation="MSLEELIAQADERGLAVSGVACLDRCVPLLGGDDEALRPLWGTLA
                     GGPSDGDWGEVLQQTREKLDAAAGEAAGGGAGEAAELARGMLATAPLDRSGTALRQWAD
                     GCSAGALRIHLLLDGGGDAEVTDLTAARREGRTDGLSPLLAAELRRQTAVLELVAAHGA
                     AALRSALEVSTEGRRVLRAAVSRRSRRDA"
     gene            complement(14589..15095)
                     /locus_tag="EBH12_RS13735"
     CDS             complement(14589..15095)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527832.1"
                     /locus_tag="EBH12_RS13735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_048460813.1"
                     /transl_table=11
                     /translation="MGYWGYFVVGRAERPLTGLDALAGAAGELTLRTEAPDGWQVWELP
                     GREGELGSMKELAKETGAPALFGYVMAGECVAVEAASPESGVWTACLGRDAMAGYLDGR
                     QEGLTVDDYFLEPADAAERAVFWAEEAGREVAAEDVLEVLTADPGPMAENGFFRLLDRL
                     RVVPE"
     gene            complement(15207..16757)
                     /locus_tag="EBH12_RS13740"
     CDS             complement(15207..16757)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133437.1"
                     /locus_tag="EBH12_RS13740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 20 protein"
                     /protein_id="WP_114874614.1"
                     /transl_table=11
                     /translation="MAVGALVVASGVGLGLWASNDDGGPAAAPSSPSPTPSPTRSYPLS
                     EAPRTIPAVREHTAERGPGWRPVPGHRVVVSDPALADEGRLTARELGLTYAGEKDDERP
                     GDVRLELNRDSGADPESYTLTVRGGRVTVSGPEEAGVFYGTRTLKQEIRGAGAAPEGVV
                     RDEPAKPRRGMMLDIARKHYDAGWIEDRVRELGDLKYNEIGLHFSDDQGFRIESDSHPE
                     IVSDDHLTKAQVQKIVELAESRHITVVPEIDSPGHLGAVIDAHPDLQLRTANGEAVRGA
                     IDIANPESARIVDDLLDEYAGLFPGDRWHLGGDEYQALVVPDPEAAFPGLATAAREKYG
                     SGATVEDLTTGWLNDRAATVRAHDRVPRAWNDGFFSGGSVQADEDIRVAYWTGKEIGAR
                     KPAEYLAEGREVINYNDEFLYYVLGEPLTFVYPTGERIYEQWTPRVLRGIEPVPARYDR
                     QILGGSFAIWGDLPRSQTQEQVAAGIRMPLRALAQKLWDADEPTLSWAEFRALAGRLG"
     gene            16985..17590
                     /locus_tag="EBH12_RS13745"
     CDS             16985..17590
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113897.1"
                     /locus_tag="EBH12_RS13745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
                     decarboxylase"
                     /protein_id="WP_241563145.1"
                     /transl_table=11
                     /translation="MTSQLSQHPPTTLTRRPRGATLPAHRLPELPGRVAIPEQSRGTPG
                     TPPPPEWFNDAPGPDAERVLLSCLHSPRWARLLAGHRPYPDTASLLAAADEAAYDLPPE
                     EIAEALASERLPSLPEDTYSAAHTALNAAHAAYEAKFGHVFVLCLDGVPEDEVLDRVLE
                     NIRSRLANDPEDEHQTTRDQLRLLARERLTNTLRGAGL"
     misc_feature    17706..17721
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.41"
                     /tool="antismash"
     gene            17854..18234
                     /gene="sdhC"
                     /locus_tag="EBH12_RS13750"
     CDS             17854..18234
                     /GO_component="GO:0045282 - plasma membrane succinate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0000104 - succinate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdhC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574684.1"
                     /locus_tag="EBH12_RS13750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="succinate dehydrogenase, cytochrome b556 subunit"
                     /protein_id="WP_078895343.1"
                     /transl_table=11
                     /translation="MPAGTLYRGREGMWSWVAHRVTGVLIFFFLFVHVLDTALVRVSPQ
                     AYDDVVATYKTPIVALLEYGLVAAILFHALNGLRVIAVDFWIKGARYQKQMLWTVVAVW
                     IVLMLGAIYPVLGHAARELFGS"
     gene            18240..18722
                     /locus_tag="EBH12_RS13755"
     CDS             18240..18722
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674540.1"
                     /locus_tag="EBH12_RS13755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="succinate dehydrogenase hydrophobic membrane
                     anchor subunit"
                     /protein_id="WP_048460817.1"
                     /transl_table=11
                     /translation="MSTTETSASGVGPVEGASLYSVDNPAPVIEPPRKRTKKTPKSTRG
                     NFELAAWLFMRLSGVVLVVLVIGHLLIQLVLDGGVSKIGFAFVAGRWASPFWQVWDLAM
                     LWLAMLHGANGLRTVINDYAERPNTRLWLKGLLYTATVFTILLGTLVIFTFDPNIR"
     gene            18831..20585
                     /gene="sdhA"
                     /locus_tag="EBH12_RS13760"
     CDS             18831..20585
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /GO_process="GO:0022900 - electron transport chain
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005313121.1"
                     /locus_tag="EBH12_RS13760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="succinate dehydrogenase flavoprotein subunit"
                     /protein_id="WP_048460818.1"
                     /transl_table=11
                     /translation="MKIHKYDTVIVGAGGAGMRAAIESTKRSRTAVLTKLYPTRSHTGA
                     AQGGMAAALANVEEDNWEWHTFDTVKGGDYLVDQDAAEILAKEAIDSVLDLEKMGLPFN
                     RTPNGTIDQRRFGGHSRNHGEAPVRRSCYAADRTGHMILQTLYQNCVKEGVEFFNEFYV
                     LDQLITEVDGVKKSSGVVAYELATGEIHVFQAKSVIYASGGTGKFFKVTSNAHTLTGDG
                     QAAVYRRGLPLEDMEFFQFHPTGIWRMGILLTEGARGEGGILRNKDGERFMEKYAPVMK
                     DLASRDVVSRSIYTEIREGRGCGPEGDHVYLDLTHLPPEQLDAKLPDITEFARTYLGIE
                     PYTDPIPIQPTAHYAMGGIPTNVKGEVLADNTTVVPGLYAAGEVACVSVHGANRLGTNS
                     LLDINVFGKRAGIAAAEYAQTADFVELPEDPESLVVGQIERLRSSTGNERVAELRRELQ
                     ETMDANVMVFRTEQTIKTAVEKIAELRERYKNVAIQDKGKRFNTDLLEAVELGNLLDLA
                     EVMAVSALARKESRGGHYREDYPNRDDVNFMRHTMAYREVGADGTETVRLDYKPVVQTR
                     YQPMERKY"
     gene            20585..21364
                     /locus_tag="EBH12_RS13765"
     CDS             20585..21364
                     /EC_number="1.3.5.1"
                     /GO_function="GO:0008177 - succinate dehydrogenase
                     (quinone) activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019066874.1"
                     /locus_tag="EBH12_RS13765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="succinate dehydrogenase iron-sulfur subunit"
                     /protein_id="WP_048460819.1"
                     /transl_table=11
                     /translation="MATPVLDKADAAGSPEPGFADSPYITVTLRIRRFNPEISAEATWE
                     DFQLEIDPKERVLDALHKIKWDLDGTLTFRRSCAHGICGSDAMRINGKNRLACKTLIKD
                     INPEKPITVEAIKGLTVLKDLVVDMEPFFQAYRDVMPFLITKDTNEPTRERLQSAEDRE
                     RFDDTTKCILCAACTSSCPVFWNDGQYFGPAAIVNAHRFIFDSRDEAGEQRLEILNDKD
                     GVWRCRTTFNCTDACPRGIEVTKAIAEVKRALITRRY"
     CDS             complement(21358..21591)
                     /gene="allorf_2955953_2956186"
                     /locus_tag="allorf_2955953_2956186"
                     /protein_id="allorf_2955953_2956186"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSGTDRIAWLPPSGPAAGRASSRGAVPSGARAPDGHTAWCGRTTR
                     GQWRQHAVTAKRPRARLRVGDGPSGWYGAVPQ"
     CDS_motif       complement(21517..21591)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSGTDRIAWLPPSGPAAGRASSRGA"
                     /locus_tag="allorf_2955953_2956186_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21358..21516)
                     /prepeptide="core"
                     /locus_tag="allorf_2955953_2956186_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.50"
                     /molecular_weight="5545.1"
                     /monoisotopic_mass="5541.9"
                     /core_sequence="VPSGARAPDGHTAWCGRTTRGQWRQHAVTAKRPRARLRVGDGP
                     SGWYGAVPQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSGTDRIAWLPPSGPAAGRASSRGA"
                     /leader_location="[21516:21591](-)"
                     /alternative_weights="5563.1"
                     /alternative_weights="5581.2"
                     /alternative_weights="5599.2"
                     /alternative_weights="5617.2"
                     /alternative_weights="5635.2"
     CDS             21495..21725
                     /gene="allorf_2956090_2956320"
                     /locus_tag="allorf_2956090_2956320"
                     /protein_id="allorf_2956090_2956320"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPVHQRGRHRGTMPGRRRDRRVGAMRSGPCLTRSPAPGAFALRWP
                     PPILGRVLPGPDVAGEAPVRCVPARLPAGPR"
     CDS_motif       21495..21566
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPVHQRGRHRGTMPGRRRDRRVGA"
                     /locus_tag="allorf_2956090_2956320_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21567..21725
                     /prepeptide="core"
                     /locus_tag="allorf_2956090_2956320_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.90"
                     /molecular_weight="5344.3"
                     /monoisotopic_mass="5340.9"
                     /core_sequence="MRSGPCLTRSPAPGAFALRWPPPILGRVLPGPDVAGEAPVRCV
                     PARLPAGPR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPVHQRGRHRGTMPGRRRDRRVGA"
                     /leader_location="[21494:21566](+)"
                     /alternative_weights="5362.3"
     misc_feature    22414..22429
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.84"
                     /tool="antismash"
ORIGIN
        1 cctggagaag aaggccgccg agcaccggcg gctcgccaag gagaaggccg ccgcacgcga
       61 cgcgcttgca caactgccgg gcggggcagg cgatcggcac gacggtccgg catgatctga
      121 cgggacggta caaacgaacg ggaccgtccc gcgcaggcac gacggacgta cgcgaggcgt
      181 acggagaaga gggagaccgc gatgagcgca cccgacggca gcccggtcgg cgccgaacgc
      241 agcatcggcc agttgttcgc cacggcgacg gcggagatgt cggcgctggt gcacgacgag
      301 atcgcgctgg cgaaggcgca gctcaggcag gacgtgaagc ggggcgcgac cagcggcggc
      361 gcgttcatgg cggcgggcgt gctgctgttg ttctccctgc cgatgctgaa cttcgcgctc
      421 gcctacggca tccgcacgtg gagcggctgg aacctggcgg tgtgcttcct gctgtccttc
      481 gcggcgaact gcctcgtcgc cgggctcctc gccctcatcg gcgtcgtctt cgccaagaag
      541 gccaagaagg gccgcggccc gcagaaggtc gccgcctcgg tgaaggagac ggccggcgtg
      601 ctgcagaagg ccaagccgca cccgcgtccg gccctccccg cgcaccgtgg ccccgaggcc
      661 atcgaggctg tggcacgctc gtcctcatga cggaccccgc cactccttcg gcgcaacctg
      721 catcggtcgt acgcctggac ctcccggacg ccccgggact cgtccaccgg gacgtcgccg
      781 ccaacggcgc ccgcttccac atcgcggagc tgggcgacgg cccgctggtg ctgctgctgc
      841 acggcttccc ccagttctgg tggacctggc ggcaccagct cacggcgctc gccgacgccg
      901 ggttccgggc cgtcgccatg gacctgcggg gcgtaggtgg cagcgaccgc accccgcgcg
      961 gctacgaccc ggccaacctc gcgctggaca tcaccggcgt gatccgctct ctgggcgagc
     1021 cggacgccgc gctcgtcggc cacgacctgg gcggctacct cgcctggacg gccgcggcga
     1081 tgcgccccaa gctcgtccgt cggctagcgg tgtcctcgat gccgcacccg cggcgctggc
     1141 gctcctcgat gctcgccgac gcccggcaga cggccgccca gtcgcacatc tggggcttcc
     1201 agcggccctg gatcccggag cgccggctca ccgcggacga cggggcgatg gtggcgcggc
     1261 tcgtccagga gtggtcgggg ccgcagccgc ccgacgagaa ggtcctggag acctaccggc
     1321 gggccatgtg cattccgtcc acggcgcact gctccatcga gccgtaccgg tggatggtgc
     1381 ggtcgctggc ccgcccggac ggcatccagt tcaaccgcag gatgaagcgc ccggtgcggg
     1441 tgccgacgct gcatctgcac ggctcgctgg acccggtggt gcgcacgcgc agcgcggcgg
     1501 gttcggggca gtacgtcgag gcgccgtacc gctggcggct gttcgacggg ctggggcact
     1561 tcccgcacga ggaggacccg gtggccttct cgaccgagct gatcaactgg ctgaaggatc
     1621 ccgagccgga ccggtgacgg gtcgaccggc catacgaacg ccaattgcct ggcgcatagg
     1681 ccaattggcg gcccctcagg cggttatcga ccttggggca ggggcacacg tccgggtatg
     1741 ggctggacgc acgactacag tgacgcaagc cgcaatcgcc gctcggcgag cggtgtgggc
     1801 tcccaccagc gaggcggtgc accacagatg gcagctacgg atctcagggt cggcatcccg
     1861 cgcattctcc gccgccgtgc gcgctgggta tcggtccggc tccgtcaccc gcggggctga
     1921 cggtccgacc ggccgttcct gacgtcccgg cagctccggt ttccgctcag agcgcgcact
     1981 tgtcgctgtc cacctcctgg gcggcgctgc ggcccctggc gatgtcctcg cggatctcgt
     2041 ccacggtcag cgcgtatccc gtctgggcgt cgtccagcga cttcgcgaag atgacgccgt
     2101 agacctcgcc ctcgggggtg aggagcgggc cgccggagtt gccctgacgg accgtcgcga
     2161 acagcgagta cacgtcgcgg cgcaccgtgc cgcggtggta gatgtcgggg ccgttggccg
     2221 tgatgcgccc ccgcagccgt gccgcgcgaa cgtcgtacgc gccgttctcc gggaagccgg
     2281 cgacgatcgc gctgtccccg ccgcccgcgt cctcggtggc gaaccggagc gcgggcgcgt
     2341 ccatgtcggg cacgtcgagc acggcgatgt cgcgcttcca gtcgtacagg acgaccgtgg
     2401 cgtcgtacgt gcggccctcg ccgcctatct gcacgaccgg ctcgtcgacg ccgcccacca
     2461 catgggcgtt ggtcatgacg cgccggtcgt cgaagacgaa gccggtgccc tccaggacct
     2521 tgccgcagct cgtcgccgtg cccgtcacct tgacgatgga gcgctgcgcg cgggcggcga
     2581 cggggctgcc cgcgagcgcc gggtcgggcg gacggacgtc cgtgatgggc tcgttggcga
     2641 acgggctgaa gacctgcggg aagccgttct gagcgaggac ggacgagaag tcggcgaacc
     2701 agatgtccgc ctggtccggc agtgcgcggg agacgccgag caggaccttg gagccgcgca
     2761 cctccttgcc gagcgtcggc agcgtcgtcc cggcgagggc ggagccgatc agccaggcga
     2821 ccaggagcat cgcgacgacg ttgacgaggg ccccgccggt ggcgtcgagg gcgcgggccg
     2881 gggaccaggt gatgtaccgg cgcagcttgt tgcccagatg ggtggtcagg gcctggccca
     2941 cggaggcgca gactatgacg accacgaccg ccacgacggc ggcggtggtg cccacctcgg
     3001 agttgtccgt catcgcgtcc cagatgacgg gcagcgtgta gacggcgatg aggccgcccc
     3061 cgaggaatcc gaccaccgac aggatgccga cgacgaagcc ctgtcggtat ccgaccacgg
     3121 cgaaccacac ggctgccacc agcagcagga tgtccagcac gttcaccgat tcccgcctcg
     3181 cctcgtccta cgcagcacgg cgcccaccct gtcacgccct ccagtccagc gggacctgct
     3241 tgtcccgatc ccaggggcgc tcccagcccg cgaagtgcag caaccggtcg atgacccccg
     3301 cggtgaaccc ccacacgagg gccgattcga ccaggaacgc gggcccgtgg aagccgctgg
     3361 ggtggatcgc ggtcgcacgg ttgtccgggt gggtgagatc ggccacgggc acggtgaaca
     3421 cccgcgccgt ctcgttcgga tcgacgacgc cgaccggggt gggctcgcgc caccagccga
     3481 gcacgggcgt cacgacgaag ccgctgacag ggatgtagag cctcggcagc acgccgaaga
     3541 gctgcacgcc ggacgggtcg agcccggtct cctcctcggc ctcgcgcagc gccgcccgca
     3601 gcggtccttc accctgcggg tcgccgtcct cggggtcgag ggcgccgccc gggaaggacg
     3661 gctgcccggc gtgcgagcgc agcgaactgg cccgctccat gagcagcagc tgggggcccc
     3721 ggccgtcctc ctcgcagcgc tcgaccgcgc gcgtgccgtc accgaagagg atcaggacgg
     3781 cggactggcg gcccgagccg tccgcgggcg gcaggaagcg gctcagctgt gtgggccgga
     3841 ccgtctcggc ggcgcggacc acagggctca gccacgcggg cagcccgtcc ctgctcaggg
     3901 ccaccgggcc cccctgcgtc ccactcgtga ccctgatgtc actcaccccc gtcatctcca
     3961 cccccgtccc acagaggcca acgcgcgacg ctcccgagat cgttccgggg cacgcgaggg
     4021 ctcccggcct gccctcatcc ggcccccagc ggcggggccg ctctgccccc ggcgtccaga
     4081 tatgcctgcg gaggcctcag ccgctggggg ccggatgagg gcaggccggg agccctcgcg
     4141 tgccccggaa cgatctcacc ggctacgacg aggtcatgcg ctgcctgcgc gaccgcgccg
     4201 tctccgccga ccgggtccgc cccctgatgg acgccgtgcc gcaaggggcc cgcgaggacg
     4261 cggagcgcgc cttctccatc ctctcccgct ggatggtctt caacgacccg ccccagcacc
     4321 gccggctgcg ccaggtcttc caggaggcct tcgccgcccg cgccgtcgcc cgctacagcg
     4381 ccttcaccga gaaggtcacc agggccgtcc tcacccgcaa agccgctccc ggccacagcg
     4441 gcgacctcat gtccgacgtg gccaaaccgc tgcccgccct cgtcttcgcc cgctggctcg
     4501 gcatcccgcc caccgacggc ccctccttct ggtactggaa cgcccgcgtc gccgacctcg
     4561 tgctcggcac cgcccaggag gagagcgagt accgggcctc cctccaagca ctggtgagcc
     4621 tggaggacta cctcggcgcg ctcgtcgaac ggcggcgcgc cgagcccggc gacgacctca
     4681 tcagccaggt cctcgccgag ggccgcgtcg gcgacaccgt cagcgagcag gagttcgtcg
     4741 gcatgctcac ccagatggct ttcgccggcg gggagaccac cagcaacctc atcgccaaca
     4801 ccgtcctggc cctgcacacc cgccccggcc agctcgccgc cgtccgcgac gaaccggacc
     4861 tggcccaggg cgccgtggag gagaccctgc gcctggacgg gccgtcgaag atgtccatcc
     4921 gcaccgccgc ccaggacctc gaactcggcg gccacaccct gcgcgcgggc gaccgggtct
     4981 tcctcgtcac cgccgccgcc aaccgcgacc ccgcccgctt ccccgacccg ggccgcttcg
     5041 acgtcacccg cagcggcgcg acccacctcg gcttcggctt cggcgcccac ttctgcatcg
     5101 gcgccgcgct cgcccgcctc gtcgccgtgt gcgccgtgcg cacgctcgtc tgcgagcggc
     5161 ccggcctggc cctcgccgac cccgcacggc tctcctggca accgtccctg ctcaaccgca
     5221 gcctcaccgc cctgcccgtc cactactgac cggaccgcac acgccccccg aagagaggca
     5281 cccccatggc cacgaccctc gccgcggacc gcccgcggct gtgggagccc gcccggcacc
     5341 gttccttccg cctgctgtgg acggggcagg cgctttccct gctcggcgac ggattcagcg
     5401 tcgtcgcctt ctcctggatc accctgagcc tgaccggctc caccctcacc ctgggctacg
     5461 tcctggcctt ccaggccgtg ccccgcgccc tgctcaccct ggtcggcggc accctcggtg
     5521 acacctggtc cacccgcacc ctcatggtgg cctccagctg gacccgcagt gccctgatgg
     5581 ccgccgtcgg catcgccgga ctcaccggac acctcaccgt gtggatgctg tgcgcggcgg
     5641 ccgccgcctt cggcgccgtc gacgccttct tccagcccgc ccgcgtctcc atccttccgt
     5701 cggtcgtcga caaggaactg ctcgccccgg ccaacgccct gctcggtgcc ggcgcgcgta
     5761 ccgccgccgt cctcggcccc gccgtcggcg gcacggtcat cgccctcacc caggcgccgg
     5821 tcgccttcct cgtcgacgcc gtctgcttcg cgctgtgcgg actgtgcgtc gcccgcatcc
     5881 gcacccgccc ccggaccgac gcgcccaagg ccgcgccgga ggagaagggg ccctccctcg
     5941 gcgcccgcat ccgcgaaggc gtcaccttca ctctgcgcga cccgcgtctg cggaccatcg
     6001 tcgccctcga caccgcggtc aacttctgtt acgcgggccc cttcacggtc ggcttcgcca
     6061 ccctcgccga ccaggtgctg cgcggcggct cggccaccct cggcgtcctc aacggcgccc
     6121 tggccggtgg agcggtcctc ggcaccctcg tcggcggggc ggtcggcgga cggccccgcg
     6181 tcggtctcct tgtcgccggc ctcgccggct ggctgggcgc cggaatggcc gtcctcggcc
     6241 tcgcccagaa caccccggtc gtcatcgcga ccgtcctcgc catgggcttc gccatcggct
     6301 accagggcgt gttcggactt agctggatcc agcgcaacat cccgcaggac gtcctcaccc
     6361 gtgtcgtctc ggtcgacatg gtcctcggtt acgccgccgc ccccctgtcg ctgatcctgt
     6421 gcggcgccct ggccgggacg ggacacctcg ccctgttcgg ggtcgtggcc gcggtcctcg
     6481 cggtcaccgg gctcgcggtg ctcgggtccc gggcggtgcg ggagatgcgc tgaacccgcc
     6541 ctcggcccgt tcagcccgag cgcagggcgg ccgaccgcgc gcacaggtcc gcgcggttgg
     6601 ccgcccccgt cttggtgatc aggctggcga tgtgcttctc cgccgtccgg ggcgagatga
     6661 acagccgatc cgcgatgtcc ttgttgctga gccgctccgc aagcagccgg aacacgtcga
     6721 actcccggac cgtcacccct tgcgtgcgca actgctcggg aatgccactg gtgccgctgc
     6781 ggtgctggtg caccggggcg cccagacggc gcagccccgc ccggcaggcg ccggtgacgg
     6841 ccgcgatgtc ccgctcgtgg aagtggtgtt cggcgcgccg cagccagctc accggatcgc
     6901 cccagccgtc ctggtgcgcg gcgtccgcga tcagccgcag ccccaggtgc tgggccagcg
     6961 gatacggctc cgccgccgcc agcgcccgct ccacggcggc cgccgcgtcc gcgccggccc
     7021 cctcccggcc cagcaggacg gcctcggcga ggtggacgaa ctgccggttc cagcgcatgc
     7081 gggccatcgc cgtcgccgtg atctccgcgt gccgggcccg gtcggcttca ccctccagca
     7141 cgtccagcag gagccccagt ccgtgggtgc cgccgagatg gtaggtggag gggttgtccg
     7201 cctccatggc ctgcaccgcc gccagttcct cgcgcgccag ctcccggttc tcctcgagca
     7261 gcgcgcagaa cgcgcccgcc aggcccctgg tgagcggctc ctcctgcgaa ccggccccgt
     7321 cccactcggt gaacgccgcc agcgtcgcct ccatggcctg ccggtcaccg cggtgggcct
     7381 ccagcgtggc ctgcgccatc accacgtacc gcacggccgg ggccagccgc agccggcgca
     7441 cgacggccag gcactccgcg gcggtgcaac gcgccacgtc gtcccgaccg cgcagcacgg
     7501 cgtccaggac gaggatgccg tcgacggtgt gcacgatgtt caccgagccc agccgcaacg
     7561 cctcctcacg ggccgacagc agcccgccgg tgtcgccctc ggccagccag gcgttgccgc
     7621 ccatgcgggt cgccgcgtac atgcgctgca acggcagccg gtgccgctcg gctgcggaca
     7681 tcgcctgtcc gagcatggcc tccgactcct gcggatcccg ctcgcgcgcg accgtggcga
     7741 gcagttccca cgcctggcag gcgacgatcg gcagcccgtg gcgctcggcc gtgtcggcgg
     7801 cggaacgcgc cagcttctcc gcgtgctggg tccggtcggg gccgggcgtg tccagggcga
     7861 ggtaggcggc ggtgacgtcc acggccgcct cggtggcctc gtcgggggtg cttgccagca
     7921 cctcgcgggc gcggaggacc tgccggttgc cgtcgctcca ccgccccgcc gtgtgcgcca
     7981 ccttggccag ccgggcgtgc agcgtcgcca gccgtacggg gctcagccct tctccgccga
     8041 gcgcgtgcag gtcgtcgacc aggtcgaagg cgcgcgcgaa gtcaccggcc tcggcgagcg
     8101 cggggagcag gttctccagg gcggcggccc gcgcctgcgg atcgcccccc tcggcgagca
     8161 gtgactcggc ccggctgagc agggtcaccg ccgagttcag ggcgcccgcg gccagggcgc
     8221 gaccaccggc gtcggcatag agcagtcccg cctcgacccg gtcgccggcc tcgcagcgca
     8281 gaccggccgc cagcgcacac cagtcgccct ccagtgccgg gtgcagctct tccacggcct
     8341 gggcgccccg tcgggccagc tccgcgcgcc ggcccggcgt catgtgggtg aacaaggcct
     8401 tcagcgtggg ggagtggcgg aaggagtacc agtcgggcgc gggttcgtcg gggaccacca
     8461 ggcgggcggc gacaccggcg tggagatggc cgagcagggt ccggtcgtcg accccggtga
     8521 cacgctggag caccgagagc gggaaacggc ggcccaggac cgcggcggcc gacatcagcg
     8581 tcagcccctg tgcgccgagc cggtcgatcc ggcgcaggat gccgcgcgcc agcgttgagg
     8641 gaacgtcacg gcgcagatca ccgacggcac gccagccacc gggaccctgc accagggtgc
     8701 ccgagccgat catggactgg agcagttcct cgacgaggta agggctgccc gcactgtcct
     8761 cccacagtcg gtcgaggacc tcggcgggga cgtcgccggg gctgtccaca ccgagctggg
     8821 cggcgatcac ctcgtgcacc tgcggccggg acagcggcgg cagttccacc acggtggcgg
     8881 ccccgcgacg gcgggccgac tgcgcgaggt ccagcgcgtc gctgatgtcg gtgcgcaccg
     8941 tcgccaccag gagcacgggc gtgcaggcca ggttgtcgac caggtactcc agaacgccga
     9001 gcgtctcggg gtcggcgtcg tgcagatcct ccaggaggag cagctgcccc tggccgcgac
     9061 cggccgcgat gagcagccgc agcacggcct cgccgagaat gaccatggaa ctgccgtcgc
     9121 gttccccggt gtcccagtcc gggatcagcc gccccagcac cgcgcggtag gggccgagcg
     9181 cgaggtcgtc catggggtcg ccgccgcgga acagcgacat cagcgcctcg gtgagcggcc
     9241 ggaacggtac ggcgggaccg gtggtgctgc tccggccgcg cagcacccgc atcccggagc
     9301 ttacggcctg gcccaccgcc tccgccgcga gccgggattt gccgaccccg gcctcgccga
     9361 ccaggaagac gacgctgccc atgccctgcc tggcgtcggc cagggagcgc tcgagctggg
     9421 tgagttggag gtcccgcccg atcaggtaag gggtatggga gcgcatgagc gctgatgata
     9481 atcggccgag tcggccgggg gcaggtcgcg ccgggccgag atctcctcca cgtgcgctgc
     9541 ggggaggcgg gtgggtgcgc gacggctgcg ggcgaccgtc cggcaacgcc gcggcgcggg
     9601 cccgctgtgg cgggcccgcg ccatcacgcg gaacggctgc cgaatgccgg tcagttgggg
     9661 gcggagaccg aggtgtccag gctgctcagc gtgatgacga tgccgctggt gaggaccatg
     9721 ccggccagca cacgggcgcg ggcgcaggcg cggttgcgac cggagagggt gatgccgccc
     9781 acgacgtcct gctcggtgtg cgcggtctcg gcggactcga cggcggtgaa ctcggcggag
     9841 tcggtggcgg cgaggtgctg gtccatgacg gtggtccctt ctggtgtccc gtgtgggcgc
     9901 gcgggttcgg atccggggag gtgccgtggt gctgacgagc gcgggtgcga gtgatgcggg
     9961 tgtgacgggt ggagcgagtg gcacggaagg tgcgggcggg tcagtggtcc gggtggtgca
    10021 ggagcaggac cgacgggacg gtcccggggt gggccaggcg gagcagtccg tagccgatgc
    10081 cggcgaggcc ggtcagcagg ccgggggagg ggacgtggtc gggggtggcg cagcggtggc
    10141 cctgtgcctc gacgagggcg aggacgtgac cggtgtgccg tcgcagcgcc gaacgggccg
    10201 tgctgtcgcc ctgctctgcc aggacggtca gggcctccag ccggccgagg acgccctggg
    10261 cgaggctgag gtcgggaccg atgggcgcgt ccgcgagccg cacagaggct tcgaacaggc
    10321 ttgcgtcgtc cggcggttcg accgggttcg gcagcccggc gacggcccgt ccggccagcc
    10381 cgtgcgacca ggacaggtcc gccggatcgc cgtgctgcgc accggagtcc agcagggcga
    10441 cggccgtgca ctcggcgcgg gcggcgcgct cggggcggtg gcccgcgtag cgccgcagcg
    10501 cccaggcgat gccggcggcg ccgtcggcga aaccggcgga cgacgggagg ccggaaccga
    10561 ccacggcgcg cgtgaccggg ccctccccga gcgcctgcgg cagcaggtcc gcgacctggt
    10621 ccgccagccg cagcgccgcc ggatcaccgg tggcctcgta cgcggcgacc gaggcggcca
    10681 gggctcccgc ccgcccctgg gccagaccgg agtcggcgca ggccaccgcc gcgtgcccca
    10741 gggcggtgag cgcgtccggc atacacgccc gcagtccctc gtcgaggagc cccgccagcc
    10801 ggaccagggc gtacacgatc ccgccgagtc cgtcgtaggc gccggggccg gcggcctcgc
    10861 tcagctcggg gtcctcggcg agcgccttga gcagggccgg cagcgggcgc accgcctcgc
    10921 gggccgccgc gccgtagcgt cccgagccgg tgagcgcctc ggtgtgggcg aggaacaggg
    10981 cgactccgca gtagccctgg gccaggcccg cccccatcgg caggacggcc cagtggtcgc
    11041 ccgacacccg ctccagaccg atccagttgg ttcgggcgcc gccgcggacc gcgcgggccg
    11101 cgatctcgtc ggcgatcccg caggcggcgg ccagcagccg ggacgggtcc ggcgccaccg
    11161 gcggcatgag ggccggtgcg agctccgacc gggggcggtc cggcggggaa ctcgccccgc
    11221 gcaccgcgag ggtggccgag atgacccact cctggtcgag gcagtcgacc tcgtccatac
    11281 ggccgatctt ctcgcgcacc gcggtcacgg cggccaccgg cagaaggtcg ggcacgcggg
    11341 caccgtcgtc ggcgatcacg gccgtgccgg tgggccggtg ggtgaagaag gggacgtcac
    11401 cgcgccacag cgccgccgtc tcgtgctcgg tgagccgctc gcgtgccggg tcctgcgcgg
    11461 actccgacca cagcaccgcg aacacccctt cccgcgccag ggcgttgccc agcagtgcgg
    11521 ggtgggtgga ctcctccagc agggtggcgt acagccgggt cgcgcgggcg atgagccggg
    11581 ccggacggtc gccccagcgg gtcaacgggc cgtcctggcc gaccagttcg ccgcggtggg
    11641 cgacgatcgc cgcgtaggcg acgcggaacc cctccagcag ggccgccctg tggtcggtga
    11701 cggagaggga agtgccgtga ggcagcgggt ggttctgggc ggcggggctg gccagcggcc
    11761 cgcgcaccgc ccgcatcgtg tccagtccgc tgtcctccca gcgcaggccc tcgccgggga
    11821 aggtgccgtc ggtgtcccgg ccgagcgcgg agatgtccag cgcgccgtgc tccccgatga
    11881 gcaggtgcgg gagcaggcag gtgcggtgga cggaggcggc cagcgcgtcc gccgccgggt
    11941 cggcgcccgc cgtgagggcc tggccgagac cggtgtgcag cagcgtctcg gcgtccacca
    12001 ggaccggctg gtcaccgtac gcgatgacgt tctcgtagtg catgtcggcg ccgtccaccg
    12061 cgtagagcag ggccagcagg gcgccttggc ggcggtagaa ggtgtcggtc tccgtcaccg
    12121 aggagcacca gcggtgctcg acgaactcca gccagccgtg ggactcccgg cgcagcgtgc
    12181 gcggggtgcg cagtcccaga ccggggacct tcgcgttgag ccaggagacc aggtcgtcga
    12241 ggagggcgtg ctggtccagc ggacggggct tgtggacgag gcggcggccg tccgcgaagt
    12301 gcaggatcgc caccgaccgg ttgccctggt gagcgtcgcc gcggccgagg tcgacgcgga
    12361 ccagccggcc cggcgtccgg ccgtcgagga gagcggcgac caggtccgcg cggtcggacc
    12421 ggaagcgggc gacgagctcg gccgtggcct ctgtcgcgtc cagcgcggtc cggctcagca
    12481 tccgcgccag gaccgggtag gcggtgaaca ggtccgacag cccgcgccgg gtgccggccg
    12541 ccgcgacgaa ggaggcgaac cgctcgcgcg ggccggcgcc cgccaggcgc cgggagcgcc
    12601 gggcccggtg cagctcctgg gccagcgtgc gggcggcgag ccggaccagc tggtgggtca
    12661 gacggcaggt gaacgcgtcc cgccacacgg tggcctcggc gtccgggacg ccggccgtcc
    12721 ggtccgcgag gcgggcggcg gccatggcga ccagggggcg cacggccggc gcgaacgcgt
    12781 cgggaccctc gccgccgacc tcgacctccg gcagcccttc ggacgcatgg gccagcacct
    12841 gctccgcgta cgacgcccag tcgggctcga cggcccgctc cgccagacgc tccgcgggct
    12901 cggcggccag ggccgccgcc gtggcgccgt ccacacccag ccggtccagc cggagggcga
    12961 agccctccgc gtcgccgacc gtccagggca gcggcccggc ggcgccggtc gcggcggccg
    13021 gcccggggag cccggcggcg ggcggccggc ccggggagcc cgggggcggc gagccgctct
    13081 gcgagggtca gcgccggggc ccaccaggcg gtggggagtc cggtgctccg ggaggtcggg
    13141 aggctggcgg tgtcggtcac gggaaaaagg tcccagacct cccgcgcccc ccacatgggt
    13201 aaccgtcccc catatccccc agcgacctca gcgtgcggga cggccaaagt gtcacaggtc
    13261 aacccacgtc ccaggactct cacggccccc gcacgccacg gcgacccacc accccgggac
    13321 accccccgga cacccttgga agccggcccg gcggggctca gtccggccgg gcccccgtcg
    13381 tcgcgtcccg gcacaggagc cggagtgagc cgtcctgggt gtagcagcgg cgggcctcgt
    13441 cgatggggtc ccagaggcgg ccgtcgggag tgcggaccca gtggtcgccg ccggaggccc
    13501 accactcggc gccggcctgg cgcacgatca cctcgcccgc gtaggccccg aagccccgta
    13561 gcaccagctc cacggcggcg tacggggccg actcgcggcg gatgtcctcg atcatccggt
    13621 cgacgctcca cagactgcgc gccgaatagt cgaggcgcag ccgtgcgccc tcgcgcatcg
    13681 ccgccaccgc gtccgccgcc cagcggaccg gcttcgtcgc cgccgagggc ctggtctcct
    13741 gctgtgtcgt cacagtcgtc gcagtcgtca cactctggag agcgctgcgg cgaagcgttt
    13801 cgtcaccccg atcccgcggt tccccacaac gggtgcacga ccgccccagg acgctcacag
    13861 ggccctcgcc gtatgtcccg gacccgggac ccgagagggc tctcaggcat cccgtcggct
    13921 gcggcgcgag accgccgcgc gcagcacccg gcgcccctcc gtggacacct ccagcgcgct
    13981 gcgcagtgcg gccgctccgt gggcggcgac gagttccagg acggcggtct gccgccgcag
    14041 ttcggcggcg agcagcggcg acagcccgtc cgtgcggccc tcacggcggg cggccgtcag
    14101 gtcggtgacc tcggcgtcgc cgccgccgtc cagcagcagg tggatccgca gcgcgccggc
    14161 cgagcacccg tcggcccact gccgcagcgc cgtcccggac cggtccaggg gggcggtggc
    14221 gagcatgccc cgcgccagct ccgccgcctc gccggcgccg ccgcccgcgg cttcgcccgc
    14281 cgccgcgtcc agcttctcgc gcgtctgctg gagcacctcg ccccagtcgc cgtcggaggg
    14341 acccccggcg agggtgcccc acagcggccg cagcgcctcg tcgtcaccgc ccagcagcgg
    14401 cacgcaccga tccaaacaag ccaccccgct gacggccagt ccgcgctcgt cggcctgtgc
    14461 gatcagttcc tccaggctca tccacgcctc cctctgcggg ttccgcaggc cccctgatga
    14521 ggccttgacg ggcgtcgtcc ctcacggagc ccgcatttcc ccttactgcg tgcgacaagc
    14581 cgggagtgtc actcgggcac cacgcgcaac cggtcgagca gccggaagaa accgttttca
    14641 gccatcggtc cggggtcggc ggtcagcact tccaggacgt cctcggcggc gacctcgcgc
    14701 ccggcctcct cggcccagaa gacggcccgc tcggcggcgt cggccggttc caggaagtag
    14761 tcgtcgacgg tgaggccctc ctgacgcccg tcgaggtacc cggccatcgc gtcccggccg
    14821 aggcaggccg tccacacccc gctctcgggg gacgcggcct ccacggccac gcactcgccg
    14881 gccatcacgt agccgaacag cgcgggcgcg cccgtctcct tcgccagttc cttcatgctg
    14941 cccagctcgc cctcgcggcc cggcagttcc cacacctgcc agccgtccgg ggcctccgtg
    15001 cgcagggtca gctccccggc cgcaccggcc agcgcgtcca gtccggtcag cggccgctcc
    15061 gcgcggccca cgacgaaata accccagtag cccatgtgcc ggtgttcccc ccgcatgtcg
    15121 gttcccggcc cggcgtgccg agccgtcggc tcgcccagaa caccaccaca gccgtacggg
    15181 ggttcgcagg cgttcgcggc aatccgtcag ccgagccggc ccgccagggc gcggaactcg
    15241 gcccaggaca gcgtgggttc gtccgcgtcc cacagtttct gggcgagggc cctcagcggc
    15301 atccggatgc cggccgcgac ctgctcctgg gtctgggagc ggggcaggtc gccccagatg
    15361 gcgaaggagc cgccgaggat ctgccggtcg taccgggcgg ggacgggctc gatgccgcgc
    15421 agcacccgcg gggtccactg ctcgtagatg cgctcgccgg tcgggtagac gaaggtgagc
    15481 ggctcgccga ggacgtagta aaggaactcg tcgttgtagt tgatcacctc gcggccctcg
    15541 gccaggtact cggcgggctt gcgcgcgccg atctccttgc cggtccagta ggcgacccgg
    15601 atgtcctcgt cggcctggac ggacccgccg gagaagaagc cgtcgttcca ggcgcggggg
    15661 acgcggtcgt gggcgcggac ggtggcggcg cggtcgttga gccagccggt ggtgaggtcc
    15721 tcgacggtgg cgccggagcc gtacttctcg cgggccgcgg tggcgagtcc ggggaaggcc
    15781 gcctcggggt cggggacgac gagggcctgg tactcgtcac cgccgaggtg ccaccggtcg
    15841 ccggggaaga ggccggcgta ctcgtccagc aggtcgtcga cgatccgggc ggactccggg
    15901 ttcgcgatgt cgatggcgcc gcgcaccgcc tccccgttcg ccgtgcgcag ctggaggtcg
    15961 gggtgggcgt cgatgacggc gccgaggtgg ccgggtgagt cgatctcggg gacgacggtg
    16021 atgtgccggc tctccgcgag ttcgacgatc ttttggacct gcgccttggt gaggtggtcg
    16081 tcggacacga tctccggatg cgagtcggac tcgatgcgga agccctggtc gtcggagaag
    16141 tgcagaccga tctcgttgta cttcaggtcg cccagctcgc ggacgcggtc ctcgatccag
    16201 ccggcgtcgt agtgcttgcg cgcgatgtcc agcatcatgc cgcgccgcgg cttggcgggt
    16261 tcgtcgcgca ccacgccctc gggggcggcg ccggccccgc gtatctcctg cttgagggtg
    16321 cgggtgccgt agaagacgcc cgcctcctcc ggcccgctga cggtgacccg cccgccgcgc
    16381 acggtcaggg tgtacgactc cgggtcggcg ccggagtcgc ggttcagctc caggcgcacg
    16441 tcgccgggcc gctcgtcgtc cttctccccc gcgtacgtca ggcccagctc cctcgcggtc
    16501 agccggccct cgtcggcgag cgccgggtcg gacacgacca cccggtgccc cgggacgggc
    16561 cgccagccgg ggccgcgctc cgcggtgtgc tcgcgcacgg cgggtatggt ccggggcgcc
    16621 tcggacagcg ggtagctgcg ggtggggctc ggcgtcggcg acggcgagga gggggcggcc
    16681 gccggaccgc cgtcgtcgtt cgaggcccac aggccgaggc ccacgccgga ggccaccacc
    16741 agcgccccca cggccaccgc gacggcggtg accctccgcc gcctcgccgt cgcctccgcg
    16801 ccgggaccgc gcctgcgctg accgtgctgc ctgcgctgac cgtgctgcct gtggtgcctg
    16861 tgccgactca ccctgccaac gtacgacccg ttcgggtgag aagcgtccac atgccgttct
    16921 caaactctgc cgtccgggtg aaatgggggt accgatcgga cacgtctcgg actcactcga
    16981 taacgtgacg tcacaactct cacagcatcc gccaacgaca ctcacgcgac gcccacgagg
    17041 agccacgctg cctgcgcacc gactcccaga gctccccggc cgagtcgcca tacccgaaca
    17101 gtcccgcggc acgcccggaa ccccgccccc gccggagtgg ttcaacgacg ctcccgggcc
    17161 ggacgccgaa cgcgtcctgc tgtcctgcct gcacagcccc cgctgggccc gcctgctggc
    17221 cggccaccgc ccctaccccg acacggcgtc cctcctggcc gccgcggacg aggcggcgta
    17281 cgacctcccc ccggaggaga tcgccgaggc cctggcctcc gagcgcctgc cctcgctccc
    17341 cgaggacacc tactcggccg cccacaccgc cctgaacgcc gcccacgcgg cctacgaggc
    17401 caagttcggc cacgtcttcg tcctctgcct ggacggcgtc cccgaggacg aggtcctcga
    17461 ccgcgtcctg gagaacatcc ggtcacgatt ggcgaacgat cccgaggacg agcaccagac
    17521 caccagggac caactccgcc tgctcgccag ggagcgcctg accaacaccc tcaggggcgc
    17581 ggggctgtga cgatgtgcga ctccgccgcg tgagcgcgag cagcccccac accaccgcac
    17641 ccggcaaatg accgcaaacg ccccacatct gtagccgcgt ccacaccaca ggcccccttt
    17701 tcgggtgcaa gtttgatcac accggcaggc cccccgtaag cgccgcaggc aaccgtcgct
    17761 accatgctgg gggccggtgg accgtacccg gccgggcccg accgacaagg aaagccggcg
    17821 cggccccaat ccccgctccc ggaggaaatt tccgtgccgg ctggaacgct gtaccgcggc
    17881 cgggaaggaa tgtggtcctg ggtggctcac cgagtcaccg gcgtcctcat cttcttcttc
    17941 ctgttcgttc acgtgctgga caccgctctc gtgcgggtgt ccccgcaggc ctacgacgac
    18001 gtcgtggcca cgtacaagac gccgatcgtc gcgctgctgg agtacggcct cgtcgccgcc
    18061 atcctcttcc acgcgctcaa cggcctgcgt gtcatcgccg tcgacttctg gatcaagggc
    18121 gcccggtacc agaagcagat gctctggacc gtcgtcgccg tgtggatcgt gctgatgctc
    18181 ggggcgatct accccgtcct cggccacgcc gctcgtgaac tgttcgggag ctgacgcaga
    18241 tgtccacgac tgaaacctcc gcctcgggcg tcggccccgt cgaaggcgcc tcgctgtact
    18301 ccgtcgacaa cccggcgccg gtcatcgagc cgccgcgcaa gcggaccaag aagaccccga
    18361 agagcacccg cggcaacttc gagctggccg cgtggctgtt catgcgcctg tccggtgtcg
    18421 tcctggtcgt gctggtcatc ggccacctgc tgatccagct ggtgctggac ggcggtgtct
    18481 ccaagatcgg cttcgccttc gtggcgggcc gctgggcgag ccccttctgg caggtctggg
    18541 acctggcgat gctgtggctg gcgatgctgc acggcgccaa cggcctgcgc acggtcatca
    18601 acgactacgc cgagcggccg aacacccgcc tgtggttgaa gggcctgctc tacacggcca
    18661 cggtgttcac catcctgctg ggcacgctgg tgatcttcac cttcgacccg aacatccgct
    18721 aggcacgggg ctgcgagaat catgctgcat ttcccggagg acaacccccg gacccccggc
    18781 ggatgctcgc accaccgtct ccgacaaagc cccgcagtga ggcgagatca gtgaagatcc
    18841 acaagtacga cacagtcatc gtcggcgccg gtggcgccgg tatgcgcgcc gccatcgagt
    18901 cgacgaagcg cagccgcacc gccgtgctga ccaagctcta ccccacccgc tcccacacgg
    18961 gcgccgcgca gggcggcatg gccgccgcgc tggccaacgt ggaggaggac aactgggagt
    19021 ggcacacctt cgacacggtc aagggcggtg actacctggt cgaccaggac gccgccgaga
    19081 tcctggcgaa ggaggccatc gactccgtcc tcgacctgga gaagatgggc ctgccgttca
    19141 accgcacccc gaacggcacc atcgaccagc gccgcttcgg cggccactcc cgcaaccacg
    19201 gcgaggcccc ggtccgccgg tcctgctacg ccgcggaccg caccggccac atgatcctcc
    19261 agacgctgta ccagaactgc gtcaaggagg gcgtggagtt cttcaacgag ttctacgtcc
    19321 tggaccagct gatcaccgag gtcgacggcg tcaagaagtc gtccggcgtc gtggcgtacg
    19381 agctggcgac cggcgagatc cacgtcttcc aggcgaagtc cgtgatctac gcgtccggcg
    19441 gcaccggcaa gttcttcaag gtgacgtcga acgcgcacac gctgaccggt gacggccagg
    19501 ccgccgtgta ccgccggggt ctgccgctgg aggacatgga gttcttccag ttccacccga
    19561 ccggcatctg gcgcatgggc atcctgctca cggagggcgc ccgcggtgag ggcggcatcc
    19621 tgcgcaacaa ggacggcgag cgcttcatgg agaagtacgc gcccgtcatg aaggacctcg
    19681 cctcgcgcga cgtcgtctcc cgctccatct acacggagat ccgcgagggc cgcggctgcg
    19741 gtcccgaggg cgaccacgtc tacctggacc tcacgcacct cccgccggag cagctggacg
    19801 ccaagctgcc cgacatcacg gagttcgcgc ggacctacct cggcatcgag ccctacacgg
    19861 acccgatccc gatccagccc accgcgcact acgcgatggg cggcatcccc accaacgtca
    19921 agggtgaggt cctcgcggac aacaccacgg tcgtccccgg tctgtacgcg gccggcgagg
    19981 tggcctgcgt gtcggtgcac ggcgccaacc gtctgggcac caactcgctg ctggacatca
    20041 acgtgttcgg caagcgggcc ggcatcgcgg cggcggagta cgcgcagacc gcggacttcg
    20101 tcgagctgcc ggaggacccg gagtccctcg tggtcggcca gatcgagcgg ctgcggtcct
    20161 ccaccggcaa cgagcgggtg gccgagctgc gccgcgagct gcaggagacc atggacgcga
    20221 acgtcatggt gttccgcacc gagcagacca tcaagacggc ggtcgagaag atcgccgagc
    20281 tgcgcgagcg ctacaagaac gtcgccatcc aggacaaggg caagcggttc aacaccgacc
    20341 tgctggaggc cgtcgagctg ggcaacctgc tggacctggc cgaggtcatg gccgtgtccg
    20401 cgctggcccg caaggagtcc cgcggcggtc actaccgcga ggactacccg aaccgcgacg
    20461 acgtcaactt catgcgccac acgatggcgt accgcgaggt cggcgccgac ggcaccgaga
    20521 ccgtccgtct ggactacaag ccggtcgtcc agacccgcta ccagccgatg gagcgtaagt
    20581 actgatggct acccccgtac tggacaaggc ggacgcggcc ggctcccccg agcccggctt
    20641 cgccgactcc ccctacatca ccgtcaccct gcggatccgc cggttcaacc cggagatctc
    20701 cgcggaggcg acctgggaag acttccagct ggagatcgac cccaaggagc gtgtcctcga
    20761 cgcgctgcac aagatcaagt gggatctgga cggcaccctg accttccgcc gttcctgcgc
    20821 ccacggcatc tgcggctccg acgccatgcg gatcaacggc aagaaccgcc tggcgtgcaa
    20881 gacgctgatc aaggacatca accccgagaa gccgatcacg gtcgaggcca tcaagggcct
    20941 gacggtcctc aaggacctgg tcgtggacat ggagccgttc ttccaggcgt accgggacgt
    21001 gatgcccttc ctgatcacga aggacaccaa cgagccgacg cgtgagcggc tccagtccgc
    21061 cgaggaccgc gagcgcttcg acgacacgac caagtgcatc ctgtgcgccg cgtgcacctc
    21121 gtcgtgcccg gtgttctgga acgacggcca gtacttcggc ccggccgcga tcgtcaacgc
    21181 gcaccgcttc atcttcgact cgcgtgacga ggccggcgag cagcgcctgg agatcctcaa
    21241 cgacaaggac ggcgtgtggc gttgccgcac cacgttcaac tgcacggacg cctgcccgcg
    21301 cggtatcgag gtcaccaagg cgatcgccga ggtgaagcgc gcgctcatca cgcgccgcta
    21361 ctgaggcacg gcgccgtacc accccgaggg cccgtctccg acccggagac gggccctcgg
    21421 gcgtttcgcg gtgaccgcgt gctggcgcca ctgcccgcgt gtagtgcgtc cgcaccaggc
    21481 cgtgtgcccg tccggtgccc gtgcaccaga ggggacggca ccgcgggacg atgcccggcc
    21541 ggcggcggga ccggagggtg ggagccatgc gatccggtcc gtgcctgaca cgctcccccg
    21601 cccccggcgc cttcgcgctc cggtggccgc cccctatcct gggccgcgtg ctgccaggtc
    21661 cggacgtcgc gggtgaggca ccggtccggt gcgtcccggc gcggctcccg gcgggcccgc
    21721 ggtgaacccg gtggtgacgc gtaccggcac ccgccggtgg cgggaagggg cggtcgtcgc
    21781 ggccgcgttc gtggtctgcc tgctcggggg gaccgtgcgg gtcgaggaca cgctcaccgc
    21841 gccgccgccg gcctcctggc tgctcgccct ggtgtcctgc gccgtactgc ccgcgcggca
    21901 ccggcgcccc ctggctgtgc tggccttcac caccgcggcc ggtgtcgccg cccagcctct
    21961 cggcctgttg ctgagtccgc ttctgatcgc acccgccctc gtcgccgcct acgcctgcac
    22021 gctgcacgtg cccggcgaac ggcgtgcggc gggcgccgtg gcgctggccg ccgtggcgct
    22081 gctggccggg tccggtccac tggccgggga cctctcctgg cgggacgcga gccggatggc
    22141 gacggtggtg gcggcgccgc tgctggcggg gctgatcggg cacgcggtgc ggacccggcg
    22201 ggcgtatctc gcggccgtgg aggagcgcgc gcggcgggcc gaggagagca gggagctgga
    22261 ggcgcgacgg cgggtcgcgg aggagcgggt gcggatcgcc cgcgagctgc acgacctggt
    22321 ggcgcaccag atcacgctgg ccaacgcgca ggccacggtc gccgcccact tcttcgacag
    22381 ccgcccggag cagacccgcg tgagcctgcg cgaactcgtc gagaccaccg ggcacgccct
    22441 cgacgaactg cgcgccacgg tcgggttgtt gcggcagacc ggggacacgg ccgcgcccga
    22501 cgggcccgcg cccgggctgg accggctgcc ggacctgctg gagtccttcc ggcgggccgg
    22561 gctggaggtg tcggtgcgtg aggagggcgc ggcgcgggcg ctgccgccgg gcgtggacct
    22621 cacggcgtac cggatcgtgc aggaggctct gaccaacgtg accaagcacg cggcgggccg
    22681 tggcgcccgg gtgggactcg actggggcgg cgggcggctg accgtcaccg tgtccgacga
    22741 cgggggcgct gcggccgggc cgcccgccct gtcggaccgg ccgcccgggt acgggctgat
    22801 cggcatgcgg gagcgcgccg ccgcggtggg cggggagctg acggcgggtc cgcgcccgga
    22861 ggggggcttc ctggtgaccg cccggctgcc cctgccgccc gtaagggaat cggcgacggc
    22921 cgacgaggaa ggac
//
