LOCUS       NZ_RAII01000001        21086 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2137690
            Orig. end                         :: 2158776
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    9..24
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.17"
                     /tool="antismash"
     gene            159..923
                     /locus_tag="EBH12_RS09805"
     CDS             159..923
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="EBH12_RS09805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_048455690.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEGGTAVRTARVPKYYRLKKHLLDMTETAPPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDLGYITADDRLAGLLDITTGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLTKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDRDGQPVEWVRSVYRGDRYKFVARLKRPQD"
     gene            1172..1393
                     /locus_tag="EBH12_RS09810"
     CDS             1172..1393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522900.1"
                     /locus_tag="EBH12_RS09810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_086701687.1"
                     /transl_table=11
                     /translation="MRVVIGLCLLAPFVAMLWVGSYAKTDPVVIGIPFFYWYQMLWVLI
                     STVLTMIAYKLWQRDQRARSATKGGAEQ"
     gene            1390..3018
                     /locus_tag="EBH12_RS09815"
     CDS             1390..3018
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="EBH12_RS09815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_114874774.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFLFFFVLVTVMGFLAARWRKAANEHTLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFIKDLPLLLAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFASAQEAYSETNPATGAPRGSLVPGEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVQNGQLAIPQLFENMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPKQETAVSKIVSLLVKVGAL
                     AFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALIGGWAVGMIYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVINVLVTVVLTFVMRAVKAPEGVDETEP
                     RDYTADAGDPGVQVELPPATAGSAH"
     gene            3098..3601
                     /locus_tag="EBH12_RS09820"
     CDS             3098..3601
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="EBH12_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_048455693.1"
                     /transl_table=11
                     /translation="MDIVIRPATPGEHAELGEITAQAYLGDGLLDFGESDTYLGELRDV
                     GKRAAAAEVLAAVADGTLLGGVTFVPGPGPMADIAEPGEAEMRMLAVSPAHRGRGAGEA
                     LVRACADRARALGRTRMVLSTQRTMHSAHRVYERLGFTRAPGRDWNPLPELDDIMLLVY
                     ELTL"
     misc_feature    3649..3663
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.73"
                     /tool="antismash"
     regulatory      3661..3822
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    3680..3694
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    3688..3701
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(3885..3896)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            3947..6304
                     /locus_tag="EBH12_RS09825"
     CDS             3947..6304
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444560.1"
                     /locus_tag="EBH12_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_107080803.1"
                     /transl_table=11
                     /translation="MTIAPADPASATRVTEESDGPGAALLRTLTQLTADLPDTDAGRVA
                     AAALRGRSAAADEAELRDLATEAAAGLISEDPAYSRLAARLLTLGIRAEAASQGVTSFT
                     GSVAAGHREGLIGDRTAAFVRLHAARLDSLVDTDADDRFGYFGLRTLHSRYLLRHPVTR
                     KVVETPQHFLLRVACGLAEDESERALEDVAALYGLMSRLDYLPSSPTLFNSGTRHPQMS
                     SCYLLDSPKDELDSLYERYHQIARLSKHAGGIGLSFSRVRARGSLIRGTNGHSNGIVPF
                     LKTLDASVAAVNQGGRRKGAAAVYLETWHADIEEFLELRDNTGEDARRTHNLNLAHWVP
                     DEFMRRVADDAQWSLFSPVDVPELADLWGEEFDAAYRAAEAKGLARRTLPARELYGRMM
                     RTLAQTGNGWMTFKDTANRTANQTAEPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNL
                     AAFAGPDGMDWERLDAAVRTAVTFLDRVVDINFYPTEEASRSNSRWRPVGLGVMGLQDV
                     FFRLRMPFDSPEAKALSTRIAERIMLAAYETSAGLAERHGPLPAWERTRTARGVLHPDH
                     YGVELAWPERWEALRTRIAATGLRNALLLAIAPTATIASIAGVYECIEPQVSNLFKRET
                     LSGEFLQVNSYLVEDLKRLGVWDARTREALREANGSVQDFAWIPEDVRRLYRTAWEIPQ
                     RGLIDLAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPATRIA
                     RAARAAVPVQQPADPEAVACSLENPESCEACQ"
     gene            6361..7317
                     /locus_tag="EBH12_RS09830"
     CDS             6361..7317
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142309.1"
                     /locus_tag="EBH12_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_234309788.1"
                     /transl_table=11
                     /translation="MRYPDFYERYRDAIKNTWHVEEVDLHSDVADLAKLTPEEQHLIGR
                     LVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPD
                     DRAAAFAAVENIPSIREKAEFCFRWMDSVEKIDRLESQADRRRFLLNLICFAACIEGLF
                     FYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVVDTVRKEEPELFDEELGR
                     QVTDMLREAVEAELQFARDLCGDGLPGMNTASMRQYLECVADQRLVRLGFAPVYGSENP
                     FSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(7337..7558)
                     /locus_tag="EBH12_RS09835"
     CDS             complement(7337..7558)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134746.1"
                     /locus_tag="EBH12_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_063837933.1"
                     /transl_table=11
                     /translation="MNTTQTEALIAMVAVLGLFVLMVAPAVIGILRDRRIDRQIRRAEA
                     APVTEPPDTRAASRPEHRAASHHHARAA"
     misc_feature    complement(7619..7633)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.9"
                     /tool="antismash"
     gene            7652..8614
                     /locus_tag="EBH12_RS09840"
     CDS             7652..8614
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700022.1"
                     /locus_tag="EBH12_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_114874772.1"
                     /transl_table=11
                     /translation="MLRNVAAVLLDGVNPFELGVVCEVFGIDRSDDGLPVYDFAVASAE
                     GPAVRTSTGFTLQTEHGPERLETADLITVPAGASYAARKFPPEMLDALRRAVDRGARVL
                     SVCSGVFVLAAAGLLEGRRAAVHWKHAEELSRRYPHLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANRIARRMVVPPHRDGGQAQYIERPLPEPGGDSVAGVLVWME
                     QHLDEEVTVEQLAARALMSPRTFARRFQQETGTTPYRWILRQRVLLAQHLLERTDETVD
                     AIAGRTGFGNAAALRHHFVRAVGTTPQSYRRAFRGPEAA"
     gene            complement(8637..10004)
                     /locus_tag="EBH12_RS09845"
     CDS             complement(8637..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190553.1"
                     /locus_tag="EBH12_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_114874771.1"
                     /sec_met_domain="p450 (E-value: 1.4e-71, bitscore: 240.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVRPEDATATAEPPVAGGAVPLLGHGWRLVRDPLAFLSQLR
                     DHGDVVRLKLGPKTVYAVTTPALTGAVALSPDYIIAGPLWESLESLLGKEGVATANGTL
                     HRRQRRTIQPAFRLDAIPAYGPIMAEEAYELVERWRDAGGVLDITYESFRAAVRVAARC
                     LMRGGYMDAHADRICADLTTLFAGMYQRMVVPLGPLYKVPLPANREFNRALADLHVLVD
                     EIVADRRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVIAILTPGAETVGSTVMSLL
                     LVLTEHPELGDKIRDEVKSVVGDRRVTFDDVRRLTYTANVVTETLRLYPAVWILTRRAV
                     ADTELGGYRIPKGADLIYSPYAVQRDRRSYERNEDFDPDRWLPERSKDVPKYAMSPFSV
                     GNRKCPSDHFSMAELTLITAVVAHAYRFEQAPDSDPRPRIGITLRPRRLMLRARPR"
     gene            complement(10001..11086)
                     /gene="cyc1"
                     /locus_tag="EBH12_RS09850"
     CDS             complement(10001..11086)
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="EBH12_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_114876143.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-65, bitscore: 220.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALSHGSTSTPTTIAVPPALSLPVIEAAFPRQLHPYWPKLQRET
                     RAWLLEKRLMTPEKVEEYADGLCYTDLMAGYYIGAPDDVLQAIADYSAWFFVWDDRHDR
                     DIVHGRPESWRRLKDLLHSALDRPGDHLGHTDPVVAGLADSVRRLHAFLPDTWNARFSR
                     HFHAVIEAYDREFHNRTEGIVPTVEEYLELRRLTFAHRIWTDLLEPSAGYELPDAVRKN
                     PAYRKPALLSQEFAAWYNDLCSLPKEIAGNEVHNLGISLVTHEGMTLEEAIADVRRRVE
                     ECISEFLDAEEAALRFADRLDDGTVGGKETSAAVRACVGNMRNWFSSVYWFHHESGRYR
                     VDSWDDRSTPPYVDNATEGEK"
     misc_feature    complement(10202..10204)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11207..11222
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            complement(11303..11953)
                     /gene="def"
                     /locus_tag="EBH12_RS09855"
     CDS             complement(11303..11953)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="EBH12_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide deformylase"
                     /protein_id="WP_048455698.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVIDTEDCEKREAEWRERGTSRPIT
                     VVGNPVLHKECKDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCPDD
                     EGLRHVGVVCNPQLVELPAEKRRLDDSSEGCLSVPTAYAPLPRPDYAEVTGQDEKGNPI
                     RVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKAALKQMAENEPRYPVVAND"
     gene            complement(12076..13056)
                     /locus_tag="EBH12_RS09860"
     CDS             complement(12076..13056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="EBH12_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat domain-containing
                     protein"
                     /protein_id="WP_048455762.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRDTGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGPATDSGEPLGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERSTAAGHTYPVFDEIELWAPSPVPTWVVLLEAASEADRD
                     ALEQLASDAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGIAAPAALVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            complement(13213..14475)
                     /locus_tag="EBH12_RS09865"
     CDS             complement(13213..14475)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522889.1"
                     /locus_tag="EBH12_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HD domain-containing protein"
                     /protein_id="WP_196421240.1"
                     /transl_table=11
                     /translation="MRPRAHTVPLHTVVHLCAAVLAAGSLGTTLYHGVEDRSVALAFGT
                     LVAVGELTRRGGRGIREPAPVAAAGSLAYALLGEVAGRPAGHGAAQVVTVVLAASLLGS
                     VPHVGRGDGPALDPVTRRVLTVGFVAVCFHPLHARGAFDDFSGPGHALLLLVLLTLTAL
                     CDAVLAAALAHSRTGWPFPPLLRDELRAVPGIGAAVVATGAVMALGAAVVGLWALPVFS
                     VPLLLAQLSHRRYTAVRATYRQTIASLARATEIAGCTPHGHSRRVAALSQAVGRDLGLT
                     EPELTVLEYAALMHDIGQLSLVDPVPEGATAGLPPAEQRRIALLGGAVVRQTGVDPRVA
                     GIVERQADPHAEQPLAARIVRVVNAYDEKCREGGPGGPLTALEELRLKAAGEYAPEVVE
                     ALARVLSRDTEGTREQMDRSW"
     gene            complement(14472..15851)
                     /locus_tag="EBH12_RS09870"
     CDS             complement(14472..15851)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134738.1"
                     /locus_tag="EBH12_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_114874770.1"
                     /transl_table=11
                     /translation="MEALPARARVHLVGVTLLGLCCLLPLTGVPRPGVLSSLPDPRVPW
                     WPVVLLAALYAGCERLARSRLVAGPHPGGTFHPVLLAGAFLLPPTAAALVALPGALLLP
                     VEHGPRLARRLWRTGRLVVAVWAAGLVHLKTGGRDAVAHCDMPGALATGGAAVLAFCLV
                     LTLLDGGVLVPAPGGLPRGRPVAAWWRLFLGSLAPLTVHGLAGLMMALLWRSPYGPVAA
                     LLVLLPMCVSWWAFAQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGRASMLIARE
                     LGMDDERVETLRFAGILHDVGKLGVPTRLLTKNGPLTPEERRVIELHPEYGHEMVRGIS
                     FLGEARAAVLHHHERLDGTGYPYGLAGGQIPESARVVAVADAFDAMTSTRSYSRARPVP
                     VALEELERCAGTHFDPRMVKALVTAIGRTGWHPAVTADEPRRTAVPGPAGHVTGRPGAR
                     R"
     misc_feature    complement(15840..15842)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15993..16295)
                     /gene="rsrA"
                     /locus_tag="EBH12_RS09875"
     CDS             complement(15993..16295)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326971.1"
                     /locus_tag="EBH12_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_048455700.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEILDHLYEFLDREMPDADCRKFEHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPGDLRSKVMGRIDLIRSGQNVPEQDVTTAPQES"
     gene            complement(16292..16978)
                     /gene="sigR"
                     /locus_tag="EBH12_RS09880"
     CDS             complement(16292..16978)
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="EBH12_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_033272060.1"
                     /transl_table=11
                     /translation="MGPVPGTDAGTEHGQAEQPEGQGDTRAESTAERSARFERDALEFL
                     DQMYSAALRMTRNPADAEDLVQETYAKAYGSFHQFREGTNLKAWLYRILTNTFINSYRK
                     KQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIA
                     VYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGESNE
                     AKGSGS"
     misc_feature    complement(16941..16956)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.19"
                     /tool="antismash"
     misc_feature    17034..17048
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     gene            complement(17238..17921)
                     /locus_tag="EBH12_RS09885"
     CDS             complement(17238..17921)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674889.1"
                     /locus_tag="EBH12_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_114874769.1"
                     /transl_table=11
                     /translation="MTPDSDVTPESDVTPESDVTTETITTDAGDARITWHHAGRPRLVL
                     AVSHGAGGGIEARDLAALAAVLPAHGVTVALVEQPWRVAGKKVAPAPKTLDTGWRGVWP
                     ALTRPGLPVVSGGRSAGARVACRTAVELGAHAVLALSFPLHPPGKPEKSRAGELLGAGV
                     PTLVVQGGNDPFGKPAEFPEGDHELVEVERADHGFAVPRRADLTQEEALHVITDAVVRW
                     TAGLR"
     gene            complement(17923..18738)
                     /locus_tag="EBH12_RS09890"
     CDS             complement(17923..18738)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="EBH12_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_114874768.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEVEKWEPEETLEADYNVAPTKEVYAVL
                     DRPLKDADDPRPVRQLRTLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFASRR
                     CILPADGYYEWVTGKQERDLEVEGKKKRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLP
                     DDHPRAWWVTCSVITTEAETSPLAVAPVDGPHTLAEIHPRMPLMLTSDRWDAWLDPSRT
                     DPEDLRGLLAPPEPGLMRAYPVTTAVSNVRNNGPELLKELAAPEEGTLF"
     gene            18799..19521
                     /locus_tag="EBH12_RS09895"
     CDS             18799..19521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="EBH12_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_048455764.1"
                     /transl_table=11
                     /translation="MVSTASASLASLWDEVAGTQPDPDLWVVVATLVAALAVVVPQAPW
                     RIARNAITIAHEGGHGLVALLTGRTLTGIRLHSDTSGLTLSRGKPTGIGMILTAAAGYT
                     APPLLGLGGAALLGAGRITLLLWLATALLLAVLVMIRNAYGAVSVLVTGGTFVLVSWLA
                     GPQVQAAFAYAVVWFLLLGGVRPAFELQAKRRHGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSVCSLLGGGRWLLGL"
     gene            19608..20924
                     /gene="aroA"
                     /locus_tag="EBH12_RS09900"
     CDS             19608..20924
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522882.1"
                     /locus_tag="EBH12_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_114874767.1"
                     /transl_table=11
                     /translation="MAPNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGGLRAMGVEIEEGVGPDGTGEAWRVVPAGLRGPATVDVGNAG
                     TVMRFLPPVATLADGPVRFDGDPRSYERPLNGVIDALRRLGARIDDDDRGALPMTVHGG
                     GALDGGTVEVDASSSSQFVSALLLSAPRFNQGMEVRHTGATLPSMPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALITGGRMVIPDWPART
                     TQPGDRLREIFTEMGGSCELTEYGLVFTGSGTVHGIDVDLGEVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYEDHRM
                     ATAGAIIGLAVDGVQIENVATTAKTLPDFPELWTGMLGA"
ORIGIN
        1 ccaccgcccg tggtctggac catcactggt cacaggggta tacaaaaggg atcacggagc
       61 gtgcgagggg ccgtcccccg cccggagccg tgccacgatg tcagccgcgg ccgacggtct
      121 gtcggccgct tcggcagccg gagccgggaa ggcagagcat gagcaccgac gtcagcagtg
      181 cggagaacga gggtgggacc gcggtccgta cggcgcgcgt gcccaagtac taccggctga
      241 agaaacacct gctcgacatg accgagaccg cgccccccgg cacgccggtc ccgcccgagc
      301 gcaccctggc ggccgagttc gacacctccc gcaccaccgt gcgccaggcg ctccaggaac
      361 tggtggtcga gggccgtctg gagcggatcc agggcaaggg caccttcgtc gccaagccca
      421 aggtgtccca ggcgctccag ctcacctcgt acaccgagga catgcgcgcg cagggtctgg
      481 agccgacctc gcagctcctc gacctcgggt acatcacggc cgacgaccgg ctggccggcc
      541 tgctcgacat caccaccggc ggccgcgtcc tgcgcatcga gcggctgcgc atggccaacg
      601 gcgagcccat ggccatcgag accacccacc tcagcgccaa acgcttcccg gcgctgcgcc
      661 gcagcctgac caagtacacc tccctctaca cggccctcgc cgaggtgtac gacgtccatc
      721 tcgcggaggc cgaggagacc atcgagacgt ccctggccac gccacgcgag gcgggcctgc
      781 tcggcaccga cgtgggcctg ccgatgctga tgctgtcccg gcactcgctg gaccgggacg
      841 ggcagcccgt ggagtgggtg cggtcggtgt accggggcga ccggtacaag ttcgtcgcgc
      901 gcctcaagcg cccccaggac tgagaccgta cggcggcggg acggcgcgcc acgcgaccgc
      961 atatcccgac agagcgggtg gttgacagga ttttcgttgc tgttgccttg cggttgcgct
     1021 gctgctgcat accgcccctc ttacgggggg ttacgaccgc cccgcgccct cacctacatt
     1081 gccgcgagcc aacgtcggcg atcagtgagg ggacgggagc cgtctgatgt cgcacagccc
     1141 gcaaacaaca ccagggccgg tggtgacgcc catgcgcgtc gtcatcggcc tctgtctgct
     1201 cgcaccattc gtcgccatgc tctgggtcgg gtcctacgcc aagaccgacc cggtggtcat
     1261 cggcatcccg ttcttctact ggtaccagat gctgtgggtg ctgatctcga ccgtgctgac
     1321 gatgatcgcg tacaagctct ggcagcgtga ccagcgcgcc cgctcggcca cgaagggcgg
     1381 tgcggagcag tgaacgacgg cgtgaacggc gtggcactcg ccgtcttcct cttcttcttc
     1441 gtgctcgtca ccgtgatggg cttcctggcc gcgcgctggc gcaaggcggc gaacgagcac
     1501 accctcgacg aatggggcct gggcgggcgg tcgttcggca cctgggtcac ctggttcctg
     1561 ctcggcggcg acctgtacac cgcgtacacc ttcgtggccg tcccggcggc catctacgcg
     1621 gcgggcgcgg ccggcttctt cgcggtgccg tacacgatcc tcgtgtaccc gctgatcttc
     1681 accttcctgc cccggctgtg gtcggtgtcg cacaagcacg gctatgtgac gacctccgac
     1741 ttcgtacgcg ggcggttcgg ctcgaagggg ctgtcgctgg ccgtcgcggt caccggcatc
     1801 ctggcgacga tgccgtacat cgcgctgcag ctggtcggca tccaggccgt gctggacgtg
     1861 atgggcgtcg gcggcggcga gaacaccaac tggttcatca aggacctgcc gctgctcctc
     1921 gccttcggtg tgctggccgc gtacacctac tcgtcggggc tgcgggcgcc cgcgctgatc
     1981 gcgttcgtca aggacacgct gatctacatc gtgatcgctg tggcgatcat ctacatcccg
     2041 atcaagctgg gcgggttcga cgagatcttc gcctccgcgc aggaggcgta cagcgagacc
     2101 aacccggcca cgggcgcgcc gcgcggctcg ctggtgccgg gcgaggcggg ccagtggacg
     2161 tacgccacac tggcgctggg ttcggcgctc gcgctgttca tgtacccgca ctcgatcacc
     2221 gcgacgctgt cctcgcgcag ccgtgaggtg atccgccgca acaccacgat cctgccgctg
     2281 tattcgctga tgctgggcct gctggcgctg ctcgggttca tggcgatcgc ggccggggtg
     2341 aaggtgcaga acggccagct ggccatcccg cagctgttcg agaacatgtt cccggactgg
     2401 tttgccggtg tggccttcgc ggcgatcggc atcggcgcgc tggtgccggc ggcgatcatg
     2461 tcgatcgcgg cggcgaacct gttcacccgc aacatctaca aggacttcat caagccggac
     2521 gcgacgccca agcaggagac cgcggtctcc aagatcgtgt ccctgctggt gaaggtgggc
     2581 gcgctggcct tcgtcctgac catggacaag accgtcgcga tcaacttcca gctgctgggc
     2641 ggcatctgga tcctgcagac cttcccggcg ctggtgggcg gcctgttcac ccgctggttc
     2701 caccgctggg cgctgatcgg cggctgggcg gtcggcatga tctacggcac ggtcgccgcg
     2761 tacggggtgg cgtcgccgac gcagaagcac ttcggcggct ccgccaagga gatcccgggc
     2821 atcggggaga tcggctacat cggtctcacc gccttcgtga tcaacgtgct ggtcacggtc
     2881 gtcctgacct tcgtcatgcg ggcggtcaag gcgccggagg gcgtcgacga gaccgagccg
     2941 cgggactaca cggcggacgc cggcgacccg ggcgtgcagg tggagcttcc gccggccacg
     3001 gcgggcagcg cgcactgacg ccgtcgcgca cagggcagcg ggccgccggt ggaaaaccgg
     3061 cggcccgctg tcgttcccgt acggcagact cccccgcatg gacatcgtca tccggccggc
     3121 gacgcccggc gagcacgcgg aactcggtga gatcaccgcg caggcctatc tcggcgacgg
     3181 actgctggac ttcggggagt ccgacaccta cctcggcgag ctgcgggacg tgggcaaacg
     3241 ggcggcggcc gccgaggtcc tggccgccgt ggcggacggc acgctgctgg gcggggtgac
     3301 cttcgtgccg ggccccggtc ccatggccga catcgcggag cccggcgagg cggagatgcg
     3361 gatgctggcc gtctcccccg cccaccgcgg ccggggcgcc ggcgaggccc tggtgcgcgc
     3421 ctgtgccgac cgggcgcgag cgctcggccg cacgcggatg gtcctgtcca cgcagcgcac
     3481 gatgcactcc gcgcaccggg tgtacgagcg gctgggcttc acgcgcgccc ccgggcggga
     3541 ctggaacccg ctgccggagt tggacgacat catgctgctc gtctacgaac tgacgctctg
     3601 acggctccgc acggcccttc cgcccggccg caccctcacc ccagcgcgac acaacatatg
     3661 ggtctgtcag cgacacccgg cacaagatgt atgctcatgc tcgctgtcgc cgcaggggaa
     3721 tccggtgcga atccggaact gtcccgcaac ggtgtaccca tgcctgccca cgggcgcgca
     3781 cgggagtcag tccgaggacc tgccgacagt gcgcccggcc cttccggtcc gggtgccctg
     3841 acgtccgggc ctcgcggaat gggccggtgg acgcgacgcc gcgtgcgttc gtgtgctgcc
     3901 ccctgcgctc ttcgaggccc ccgtgccgag cgagggagag ccacacgtga ccatcgcgcc
     3961 agccgatccg gcttcagcga cccgcgtgac cgaggagagc gacggccccg gggccgcgct
     4021 gctgcggacc ctgacccagc tgaccgcaga cctgcccgac accgacgccg gccgggtggc
     4081 cgccgccgcg ctgcgcggcc ggtccgccgc cgccgacgag gcggagctgc gggacctggc
     4141 caccgaggcg gcggccgggc tgatctccga ggaccccgcc tactcccggc tcgccgcccg
     4201 gctgctcacc ctcggcatcc gcgccgaggc cgcctcgcag ggcgtcacct cgttcaccgg
     4261 ctcggtggcc gccggtcacc gggagggcct gatcggcgac cgcaccgccg cgttcgtccg
     4321 gctccacgcg gcccggctgg actcgctggt cgacacggac gccgacgacc ggttcggcta
     4381 cttcggcctg cgcaccctgc acagccgcta cctgctgcgc cacccggtca cccgcaaggt
     4441 cgtcgagacg ccccagcact tcctgctgcg ggtcgcctgc gggctcgccg aggacgagag
     4501 cgagcgggcg ctggaggacg tcgccgcgct gtacgggctg atgagccggc tggactacct
     4561 gccctcctcc cccacgctgt tcaactccgg cacccgccac ccgcagatgt cgtcctgcta
     4621 cctcctggac tcccccaagg acgagctgga ctccctctac gagcgctacc accagatcgc
     4681 ccgcctctcg aagcacgccg gcggcatcgg cctgtccttc tcccgcgtcc gcgcccgggg
     4741 ttcgctgatc cgcggcacca acgggcactc caacggcatc gtcccgttcc tgaagacgct
     4801 ggacgcatcg gtcgccgccg tgaaccaggg cggccggcgc aagggcgccg ccgcggtcta
     4861 cctggagacc tggcacgcgg acatcgagga gttcctcgag ctgcgcgaca acaccggtga
     4921 ggacgcccgc cgtacgcaca acctgaacct ggcgcactgg gtgccggacg agttcatgcg
     4981 ccgggtcgcc gacgacgcgc agtggtcgct gttctccccg gtggacgtgc ccgaactggc
     5041 cgacctgtgg ggcgaggagt tcgacgccgc ctaccgggcc gccgaggcga agggcctggc
     5101 ccgcaggacg cttccggcgc gcgagctgta cggccggatg atgcgcaccc tcgcgcagac
     5161 cggcaacggc tggatgacct tcaaggacac cgccaaccgc accgccaacc agaccgccga
     5221 gccgggccac gtcgtccact cctccaacct gtgcacggag atcctggagg tcaccgacga
     5281 cggggagacg gcggtctgca acctcggttc ggtcaacctc gcggccttcg ccggcccgga
     5341 cggcatggac tgggagcgcc tggacgcggc ggtccgcacc gccgtgacgt tcctggaccg
     5401 ggtggtcgac atcaacttct acccgaccga ggaggcgtcc cggtccaaca gccggtggcg
     5461 ccccgtgggc ctgggcgtga tggggctgca ggacgtgttc ttccggctgc ggatgccgtt
     5521 cgactccccc gaggcgaagg cgctgtccac ccggatcgcc gagcgcatca tgctcgccgc
     5581 gtacgagacg tccgccggtc tggccgagcg gcacggcccg ctgcccgcct gggagaggac
     5641 ccgcaccgcg cggggcgtgc tgcaccccga ccactacggc gtcgagctcg cctggccgga
     5701 gcgctgggag gcgctgcgga cccggatcgc cgcgacgggc ctgcgcaacg cgctgctgct
     5761 ggcgatcgct cccaccgcga ccatcgcgtc gatcgcgggc gtgtacgagt gcatcgagcc
     5821 gcaggtgtcc aacctgttca agcgcgagac gctgtccggg gagttcctcc aggtcaactc
     5881 gtacctggtg gaggacctca agcggctcgg cgtgtgggac gcgcgcaccc gtgaggcgct
     5941 gcgcgaggcg aacggctcgg tgcaggactt cgcgtggatc cccgaggacg tacggcggct
     6001 gtaccgcacg gcgtgggaga tcccgcagcg cggcctgatc gacctggccg ccgccaggac
     6061 cccgttcctc gaccaggcgc agtcgctcaa cctgttcctg gagacgccga ccatcgggaa
     6121 gctctcctcg atgtacgcat acgcctggaa gcaggggctc aagaccacct actacctgcg
     6181 ctcccgtccg gcgacccgga tcgcccgcgc ggcccgcgcc gccgtccccg tccagcagcc
     6241 ggccgacccc gaggccgtcg cctgctccct cgagaacccc gaatcctgcg aggcctgcca
     6301 gtgaccacca gcacgaccaa gaacctgctc gaccccggct tcgagctgac cctgcgcccc
     6361 atgcgctacc cggacttcta cgagcgctac cgggacgcga tcaagaacac ctggcacgtc
     6421 gaggaggtgg acctgcactc ggacgtcgcc gatctggcga agctgacgcc cgaggagcag
     6481 catctgatcg gccggctcgt ggcgttcttc gccaccggcg actcgatcgt ggcgaacaac
     6541 ctggtgctga cgctgtacaa gcacatcaac tcgcccgagg cgcggctgta cctgtcgcgg
     6601 cagctgttcg aggaggccgt gcacgtccag ttctacctga ccctgctgga cacctacctg
     6661 cccgatccgg acgaccgtgc ggcggccttc gcggcggtgg agaacatccc gtccatccgg
     6721 gagaaggccg agttctgctt ccggtggatg gactcggtgg agaagatcga ccggctggag
     6781 tcgcaggccg accggcgccg cttcctgctg aacctgatct gcttcgcggc ctgcatcgag
     6841 ggcctgttct tctacggtgc gttcgcctac gtctactggt tccgcagccg gggcctgctg
     6901 cacggcctgg cgaccggcac caactgggtg ttccgcgacg agacgatgca catgagcttc
     6961 gccttcgacg tggtggacac cgtgcgcaag gaggagccgg agctgttcga cgaggagctc
     7021 gggcggcagg tcaccgacat gctgcgcgag gccgtcgagg cggagctgca gttcgcccgt
     7081 gacctgtgcg gggacgggct gcccggcatg aacaccgcgt cgatgcggca gtacctggag
     7141 tgcgtcgccg accagcgtct ggtgcggctg ggcttcgcgc cggtgtacgg ctcggagaac
     7201 ccgttctcct tcatggagct gcagggcgtg caggagctga ccaacttctt cgagcgccgt
     7261 ccgtccgcgt accaggtcgc cgtggagggc acggtcgacc tggacgagga cttctagggc
     7321 ccgggccggg gccgtctcac gccgcccgtg cgtggtggtg cgaggcggcc cggtgctccg
     7381 ggcgggacgc ggcccgtgta tcgggcggtt cggtgacggg cgccgcctcg gcccgccgga
     7441 tctgccggtc gatgcggcgg tcgcgcagga tgccgatcac ggcgggcgcg accatgagga
     7501 cgaacaggcc gagaacggcc accatcgcga tcagtgcttc tgtctgcgtc gtgttcatgg
     7561 acaccactgt ggcgccggac actcctgacc gggagtggca ggactgccgt acaccctcga
     7621 tttactgcca atggcgaggc acactggagt catgctccgg aatgtggcgg ccgtcctgct
     7681 cgacggcgtg aatccgttcg aactcggcgt ggtctgcgag gtcttcggca tcgaccgcag
     7741 cgacgacggg ctgccggtgt acgacttcgc cgtcgcctcg gcggaggggc cggcggtgcg
     7801 caccagcacc ggcttcacgc tccagaccga gcacggcccg gagcggctgg agacggccga
     7861 cctgatcacc gtgcccgccg gcgcctccta cgccgcccgg aagttcccgc ccgagatgct
     7921 ggacgcgctg cgccgggccg tggaccgggg cgcgcgcgtg ctgagcgtgt gctccggggt
     7981 gttcgtgctg gccgccgccg ggctgctgga ggggcggcgg gccgcggtgc actggaagca
     8041 cgcggaggag ctgagccgcc gctatccgca tctgacggtc gagcccgacg tgctctacgt
     8101 cgacgaggac ccggtgatca cctcagcggg caccgccgcg ggcatcgacg cctgtctgca
     8161 cctggtacgc aaggaacagg gcccggaggt ggccaaccgg atcgcccgcc ggatggtggt
     8221 ccccccgcac cgcgacggcg ggcaggccca gtacatcgag cgtccgctgc cggagcccgg
     8281 gggcgactcg gtcgccgggg tgctggtgtg gatggagcag catctcgacg aggaggtcac
     8341 cgtcgagcag ctcgccgccc gcgccctcat gtcgccgcgc accttcgccc gccgcttcca
     8401 gcaggagacc ggcaccacgc cctaccgctg gatcctgcgc cagcgggtgc tgctggccca
     8461 gcacctgctg gagcggacgg acgagacggt ggacgcgatc gcgggccgca ccggcttcgg
     8521 caacgcggcc gcgctgcgcc accacttcgt gcgcgcggtc gggaccaccc cgcagtccta
     8581 ccggcgcgcg ttccggggcc cggaggccgc ctgaccgcgc gccggacggc gggacgtcag
     8641 cggggccgcg cccgcagcat cagccggcgg ggccgcagcg tgatgccgat gcggggccgg
     8701 gggtcggagt ccggcgcctg ctcgaagcgg taggcgtggg cgaccacggc ggtgatgagc
     8761 gtgagctccg ccatggagaa gtggtcgctg ggacacttcc ggttgcccac gctgaacggg
     8821 ctcatcgcgt acttgggcac gtccttggac cgctccggga gccagcggtc cgggtcgaag
     8881 tcttcgttcc gctcgtacga ccgccggtcg cgctggacgg cgtacgggct gtagatgagg
     8941 tccgcgccct tcggaatgcg gtaaccgccg agttccgtgt cggcaaccgc gcggcgggtc
     9001 aatatccata cggccggata cagccgcagg gtctccgtga cgacattcgc ggtgtacgtc
     9061 agccgacgca cgtcgtcgaa tgtgacccgg cggtcgccga ccacggattt cacctcgtcg
     9121 cggatcttgt caccgagttc cgggtgctcg gtgagaacca ggaggagtga catgaccgtg
     9181 gatccgacgg tttcggcgcc gggggtcagg atggcgatga cctgatcatg gatctcctgt
     9241 tccccgatgg ggtcaccatt gtcgtccttc gcctccagca aagccgtcag caaatcgtcc
     9301 ggtttttgac cgctcgcccg tcggtcggcg acgatctcgt cgaccaggac atgcaaatcg
     9361 gccagtgcgc ggttgaattc ccgattggcc ggaagcggaa ccttgtagag cggtccgagc
     9421 ggcaccacca tgcgctggta catccccgcg aacagggtgg tgaggtcggc gcatatgcga
     9481 tcggcgtggg cgtccatgta gccgccgcgc atcaggcagc gggcggcgac ccgcacggcc
     9541 gcgcggaacg actcgtaggt gatgtccagc accccgcccg cgtcccgcca gcgctccacg
     9601 agctcgtagg cctcctccgc catgatcggg ccgtaggcgg ggatcgcgtc gagccggaac
     9661 gccggctgga tggtgcgccg ctggcggcgg tgcagcgtgc cgttggcggt ggccacgccc
     9721 tccttgccga gcaggctctc cagcgactcc cacaggggcc cggcgatgat gtagtccggg
     9781 ctgagcgcca ccgctccggt gagggcgggg gtggtgacgg cgtagacggt cttgggaccc
     9841 agtttcaggc gcaccacgtc gccgtggtcg cgcagctggg acaggaaggc cagcgggtcg
     9901 cgcaccaggc gccagccgtg gccgaggagc gggacggcgc cgcccgccac aggcggctcg
     9961 gccgtcgcgg tggcgtcctc cgggcgtacg gactcgacgg tcatttctca ccttccgttg
    10021 cgttgtcgac gtacgggggc gtggaccggt cgtcccagct gtcgacccgg taccggccgg
    10081 actcgtggtg gaaccagtag acggaactga accagttccg catgttgccg acgcaggcgc
    10141 gcacggcggc gctcgtctcc tttccgccca ccgtcccgtc gtcgagccgg tcggcgaacc
    10201 gtaatgccgc ctcttccgcg tccaggaatt cgctgatgca ttcctcgacg cggcgccgca
    10261 cgtcggcgat cgcctcttcg agggtcattc cctcgtgggt gacgagactg ataccgagat
    10321 tgtgcacctc gtttccggcg atttccttgg gcagcgaaca gaggtcgttg taccaggcgg
    10381 cgaattcctg actgagcagc gccggtttcc gataggccgg gttcttccgc accgcgtccg
    10441 ggagttcgta ccccgcgctc ggttccagaa ggtccgtcca gatccggtgc gcgaacgtga
    10501 ggcggcgcag ttcgaggtat tcctcgacgg tcgggacgat gccttcggtg cggttgtgga
    10561 actcccggtc gtacgcctcg atcacggcgt ggaagtggcg cgagaaccgc gcgttccagg
    10621 tgtccggaag gaacgcgtgg agccgccgca cactgtcggc gaggcccgcg accacggggt
    10681 ccgtgtggcc caggtggtca ccggggcggt cgagggcgct gtgcagcagg tccttcagcc
    10741 gccgccagga ttcgggccgg ccgtgcacga tgtcgcgatc gtgacggtcg tcccagacga
    10801 agaaccaggc gctgtagtcc gctatcgcct ggaggacgtc gtcgggcgcg ccgatgtagt
    10861 agcccgccat gaggtccgtg tagcacaggc cgtcggcata ttcctccacc ttctccggcg
    10921 tcatgagccg cttttcgagc agccatgccc gggtctccct ctggagcttc ggccaatacg
    10981 ggtggagttg ccggggaaac gccgcctcga tcaccggaag agacagcgcc ggtggaactg
    11041 cgatggtggt cggtgtcgac gtggagccgt gtgacaaagc atgcacgaac attcccctct
    11101 cagccgccag ttgagcgccc gccccccgag ccgggcgtac gccgtgcgta tccccgtacc
    11161 tccattcagc accacaactg accgttctgg gaacggattt gcttctttca ctccttttgg
    11221 atgcgcacag acgaacggcg cccgtccggg atgtgccgga tcgggcgccg tgcgcgtgat
    11281 gtgaagggag ccgtgagggc ggtcagtcgt tggcgaccac gggatagcgc ggctcgttct
    11341 cggccatctg cttgagcgcg gccttacgct cgcgcttcga cagacggtcg atgtacaggt
    11401 agccgtacag gtgatccgtc tcgtgctgga ggcagcgcgc gaagtagccc gtcccgcgta
    11461 cccggatcgg gttgcccttc tcgtcctgac cggtcacctc ggcgtagtcg ggccggggca
    11521 gcggcgcgta cgcggtgggc accgacaggc agccctcgct gctgtcgtcc agccggcgct
    11581 tctcggcggg cagttcgacc agctgggggt tgcagaccac accgacgtgg cgcaggcctt
    11641 cgtcgtcggg gcagtcgtag acgaagacct tcaggtcgac accgatctgg ttggcggcca
    11701 gacccacgcc ctcggcggtg cgctggctgg cgaacatgtc ggcgacgagc tgctggaact
    11761 cctcgccgaa gtccgtgacg tccttgcact ccttgtgcag caccgggttg ccgaccacgg
    11821 tgatcgggcg cgaggtgccg cgctcccgcc actcggcctc gcgcttctcg cagtcctccg
    11881 tgtcgatgac gtagccctcg tcgtcgacgg ggagcacgcc cgcgtgctgc tgatcggtgt
    11941 cctgctgagc catgaccgac gtgtgccttc ctgagatgac cgagaatgct gtgacaaggg
    12001 taagtgcagc gcccctcgaa ggggcgcggg gaactgcgcg ctcagccccc acggcccccg
    12061 cacccggcga cggtgctagc aaacctcttc gagatcccgc caatccctgg aatcaggact
    12121 gtcagcgacc cacccgtcca acaacccccg caccaaagcc gcaggcgcgg caatcccgca
    12181 ctccctctcc ggcacccaca actgcccgtc cgtccgatgc cccaacggcc cgggatgccc
    12241 cggctcactg tgatcgtgag gatcgagatg ctccccgtcc ccctcgtcgg acggcatccg
    12301 tgactccgag cacatccggc acaggagccg caccgacgac gaccagtcct cggccgcgaa
    12361 cccggcgtcg gaggcgagct gttccagcgc gtcccggtcg gcctcggacg cggcctccag
    12421 cagcaccacc caggtcggca ccggcgaggg cgcccacaac tcgatctcgt cgaacaccgg
    12481 gtaggtgtgc ccggctgcgg tgctccgctc gccgtgcggc accccgtcgt gcagcacgac
    12541 ctcgccccag cggcgtccgg aggacggcag cgggatggac agcacctcga tgcgggcggg
    12601 gtcgagccgc cgcccccaca ccacttcggc ctccccttcc ggtgacagcc gtacggccgc
    12661 gctgcccagg tccatgccga gaggctcgcc cgagtcggtc gctggtcccg gcaccttgag
    12721 cccgtacgcc tgccaggcac ggcgggccag cggccagtcc tggagggcgg tggcggcgat
    12781 gcccacgttc caccagtcgg gcgccccggt gtcgcggtcg agcagggcga cggcacgcag
    12841 cccggccgcg cgcgcctgct cccagtcgtg ccggaacttg tgcagcagcg cgaggttgaa
    12901 ccaggactcc gacagccagg gctccagatc ggcggcccgc gtcagcagcg cgcccgcgtc
    12961 ctcgtaccgg ccgtcgccga tgagcgtgaa cgcgcggtcc gtggcctgcc gccaggaggc
    13021 ggagggccgg tgacgtccct tgccgaagat cctcacgatt cccgcctgcc agttccgttc
    13081 ggtgggccgg ccgcagcggt cggcaccccc ggccaccctc tccttcgcat ccaaccacgt
    13141 acggccgcga gggcgctcat tacccatggg ttacccagct ctgccgggaa ccagaccgcc
    13201 cggtccgccc tctcaccacg accggtccat ctgctcacgc gtcccctccg tgtcccggga
    13261 cagaaccctg gccaaggcct cgacgacctc cggcgcgtac tccccggcgg ccttgagccg
    13321 cagttcctcc agcgcggtca gcggcccccc gggccctcct tccctgcact tctcgtcgta
    13381 cgcgttcacc acccggacga tacgggcggc gagcggctgc tcggcgtgcg ggtcggcctg
    13441 gcgttcgacg atcccggcga cccgggggtc caccccggtc tgccgcacca ccgcgccgcc
    13501 caggagcgcg atgcgccgct gctcggcggg cggcagtccc gcggtggcgc cctcgggcac
    13561 cgggtccacg aggctgagct gcccgatgtc gtgcatcagt gccgcgtact ccagcacggt
    13621 cagctccggc tcggtcagcc cgaggtcccg gcccaccgcc tggctgagcg cggcgacccg
    13681 gcgcgagtgc ccgtgcgggg tgcacccggc gatctcggtg gcgcgcgcga gggacgcgat
    13741 ggtctgccgg taggtggcgc gcaccgccgt gtacctccgg tgggacagct gcgcgagcag
    13801 cagcggcacg gagaacaccg gcagcgccca cagccccacg accgccgcgc ccagcgccat
    13861 caccgcgccg gtcgcgacga cggcggcgcc gatgccgggc acggcccgca gttcgtcgcg
    13921 cagcagcggc gggaagggcc agccggtgcg ggagtgagcc agcgcggcgg ctagcaccgc
    13981 gtcgcacagc gcggtcaggg tcagcaggac gagcagcagc agcgcgtgtc ccggcccgct
    14041 gaagtcgtcg aacgcgcccc gggcgtgcag cgggtggaag cacacggcga cgaagccgac
    14101 ggtcagcacc ctgcgggtca ccgggtccag ggcgggcccg tcgccgcgtc cgacatgcgg
    14161 gacgctgccg agcagcgacg cggcgagcac cacggtgacg acctgggcgg cgccgtgccc
    14221 ggcgggccgc cccgcgacct cgccgagcag cgcgtacgcc agcgatcctg ccgcggccac
    14281 cggcgcgggc tcccggatcc cccggccgcc ccgccgggtg agctcgccga ccgcgacgag
    14341 cgtgccgaag gcgagggcga cggagcggtc ctcgacgccg tggtaaaggg tcgtgcccag
    14401 cgacccggcc gcgaggaccg cggcgcacag atgcacgacg gtgtgcagcg ggacggtgtg
    14461 cgcgcggggc ctcaccggcg cgccccggga cggccggtga cgtgtccggc aggaccgggc
    14521 acggccgtcc gccgcggctc gtcggcggtc accgcggggt gccagccggt acggccgatc
    14581 gcggtgacga gcgccttcac catccgcggg tcgaagtgcg tgcccgcgca ccgctccagc
    14641 tcctccagcg ccaccggcac cgggcgcgcc ctgctgtagc tgcgggtgga ggtcatcgcg
    14701 tcgaaggcgt cggcgaccgc gaccactcgc gcggactccg ggatctgacc tcccgccagc
    14761 ccgtaggggt agccggtgcc gtcgaggcgc tcgtggtggt gcagcacggc ggcgcgggcc
    14821 tcgccgagga aggagatgcc gcgcaccatt tcgtgcccgt actcggggtg cagttcgatg
    14881 acccgccgct cctcgggggt gagcgggccg ttcttggtga gcagccgggt gggcacgccc
    14941 agcttgccga cgtcgtgcag gatgcccgcg aagcgcagcg tctcgacccg ctcgtcgtcc
    15001 atgccgagtt cgcgcgcgat cagcatggag gcgcggccga cgcgctcgct gtggccgcgc
    15061 gtgtagccgt ccttgatgtc gacggcctgc accagcgcgc ggatcgtggc ctggtgggcg
    15121 gcgcgctccc ggtggtactg ggcgaacgcc caccacgaga cgcacatcgg cagcagcacc
    15181 agcagtgccg cgaccggccc gtaggggctg cgccacagca gggccatcat cagtccggcc
    15241 aggccgtgca cggtgagcgg cgccagggag ccgaggaaca gccgccacca ggcggccacc
    15301 ggacggccgc gcggcagacc accgggggcg ggcaccagga cgccgccgtc gagcagggtg
    15361 aggacgaggc agaacgccag cacggcggcg ccccccgtgg cgagggcgcc cggcatgtcg
    15421 cagtgcgcca ccgcgtcgcg gccgccggtc ttcagatgga ccaggccggc ggcccacacg
    15481 gcgacgacga gccggcccgt gcgccacagc cggcgcgcga gacgcgggcc gtgttcgacg
    15541 gggagcagca gtgccccggg cagcgcgacg agggcggcgg cggtgggtgg cagcaggaag
    15601 gcccccgcga gcagcacggg gtggaaggtg ccgccggggt gcggtcccgc gacgaggcgg
    15661 gaccgggcga gacgctcgca gcccgcgtac agggcggcga gcaggacgac cggccaccag
    15721 gggacgcgcg ggtcgggcag ggacgacagc accccgggcc gggggacgcc cgtcagaggg
    15781 agcagacagc acagtcccag cagggtgacg ccgacgagat ggacccgggc ccgcgccggt
    15841 aacgcctcca tgagcccctc ccccgaccgt gccgcgcgcg ccttccgtcg cccgccggct
    15901 tctggagcct aggacggggg agggcgccgc cgcgggcgga ccgcccgcgg attagcacaa
    15961 tcgggtgacg cggcccagtg ggtggggagg tgtcaggact cctgcggagc ggtcgtgacg
    16021 tcctgctcgg gcacgttctg gccggagcgg atcaggtcga tccggcccat gaccttcgag
    16081 cgcaggtcgc cgggcacgtc gtcctgcccg caacaccgct tcacgagctt cttgaccgcc
    16141 tgctccagcc cgtacttctc caggcagggc gagcactcct cgaagtggtg ctcgaacttc
    16201 cggcagtcgg catccggcat ctcacggtcg aggaactcgt agagatgatc gaggatttcg
    16261 ctgcaatccg tctcgtgcgg ctctccgcag ctcatgaccc cgagcctttc gcttcgttcg
    16321 actctccggc accggccggg accagtccgc gctcgcgcgc gtagtcctcg agcatgccgc
    16381 gcagctggcg acgtccccgg tgaaggcggg acatcaccgt tccgatgggt gtccccatga
    16441 tgtcggcgat ctccttgtag gcaaagccct cgacatcggc gagatagacc gcgatgcgga
    16501 actcctccgg gatcgcctgc agggcttcct tcacgtccga gtccggcagg tggtccagcg
    16561 cctgcgactc ggcggagcgc agacccgtgg acatgtgcga ctcggcgcgc gcgagctgcc
    16621 agtcctcgat ctcctcggcc gcggagcgct ggggttcgcg ctgcttcttg cggtacgagt
    16681 tgatgaaggt gttggtgagg atccggtaca gccacgcctt gaggttggtg ccctcgcgga
    16741 actggtggaa ggacccgtac gccttggcgt aggtctcctg caccaggtcc tcggcgtcgg
    16801 ccgggttgcg cgtcatgcgc agcgcggccg agtacatctg gtcgaggaac tcgagcgcgt
    16861 cccgttcgaa gcgcgcgctg cgctccgctg tcgactccgc gcgcgtgtcg ccctggccct
    16921 cgggctgctc cgcctggccg tgttcggtcc ctgcgtcggt accgggaacc ggacccacct
    16981 cctcaagtgt cgtcgtgaga ccgagaccgg cctcacccga atcggaggat agacgacgat
    17041 ccggtccgcc cgccgcccga atcggggcgg tcttggccgc gtgcagcacc gtccagtcga
    17101 ggtcggcgcg ggcgctgcgg ctcgggcaga acgtggaacc catgcggtgg acttcctctc
    17161 ctacggcggc ggtgccgttc gaccggcacg tacgcacccc acaacagcgg gggcggtccg
    17221 cgcattcccg gcgcccgtca gcggaggccc gccgtccacc gcacgaccgc gtccgtgatg
    17281 acgtggagcg cctcctcctg cgtgaggtcc gcccgcctgg gcacggcgaa gccgtggtcg
    17341 gcccgctcca cctccaccag ctcgtggtca ccctcgggga actcggcggg tttcccgaag
    17401 gggtcgttgc cgccctggac gacgagcgtg gggacgcccg cgccgagcag ttccccggcg
    17461 cgggacttct ccggcttgcc cggcgggtgc agcgggaagc tcagcgcgag cacggcgtgc
    17521 gcgcccagtt cgacggcggt gcggcaggcg acgcgggcgc cggcgctgcg tccgccggag
    17581 accaccggca gaccgggcct cgtcagcgcg ggccagacgc cgcgccagcc ggtgtccagg
    17641 gtcttcggcg ccggggcgac cttcttcccg gccacccgcc agggctgctc gacgagggcg
    17701 acggtcacgc cgtgcgcggg gaggacggcg gcgagcgcgg cgaggtcgcg ggcctcgatg
    17761 ccgccgcccg cgccgtgact cacggcgagg acgaggcgcg gccgcccggc gtggtgccag
    17821 gtgatgcggg cgtcgccggc gtccgtggtg atcgtctcgg tggtgacgtc ggactcgggt
    17881 gtcacatcgg actcgggtgt cacgtcggaa tcgggtgtca cgtcagaaga gtgtgccctc
    17941 ttccggagcg gccagctcct tcagcagctc cggaccgttg ttgcggacgt tgctgacggc
    18001 ggtggtgacc gggtaggcgc gcatcaggcc gggctccggc ggggcgagca gcccgcgcag
    18061 gtcctctggg tcggtgcggg aggggtcgag ccaggcgtcc cagcggtccg aggtgagcat
    18121 cagcggcatc cgcgggtgga tctcggccag cgtgtgcggg ccgtccaccg gggccacggc
    18181 cagcgggctc gtctccgcct ccgtggtgat cacggagcag gtcacccacc aggcccgcgg
    18241 gtggtcgtcg ggcagcgtgc ggtcgcgcca gaactcgtac agtccggcca tcgcgaagac
    18301 cgagccgtcg gccggggtga cgaagtaggg ctgcttgcgg ggccgcttct tcttgccctc
    18361 gacctccagg tcgcgctcct gcttgccggt gacccactcg tagtagccgt cggcggggag
    18421 gatgcagcgg cgggaggcga aggcacggcg gtacgacggc ttctcgtgga cggtctccgc
    18481 gcgcgcgttg atcatccgtg cgccgccctc gggggtcttg gaccaggagg gcaccagtcc
    18541 ccacttcagc gtgcgcagct gccgaaccgg gcgggggtcg tccgcgtcct tcagaggacg
    18601 gtcgaggacg gcgtagacct ccttggtcgg cgccacgttg tagtcggcct ccagggtctc
    18661 ctcgggctcc cacttctcga cctcgaagat cccggcgaga tcctcgggcc tccgactcgc
    18721 tgcataccgt ccgcacatac gtgcaacact gccagactcc gcacgcgcac agggagcgat
    18781 ccaacacaca tgacgagcat ggtcagcacc gcgtccgcgt ccctcgcctc cctctgggac
    18841 gaggtcgcgg gcacccagcc cgacccggac ctgtgggtgg tcgtcgcgac cctggtggcg
    18901 gccctcgccg tggtggtgcc gcaggcgccc tggcggatcg cacggaacgc gatcaccatc
    18961 gcgcacgagg gcgggcacgg tctggtggca ctgctcaccg gccgcaccct gaccggcata
    19021 cgcctccact ccgacaccag cggcctgacc ctcagccgcg gcaagccgac cggcatcggc
    19081 atgatcctca cggccgccgc cggctatacc gctcccccgc tgctgggcct cggcggggcg
    19141 gcgctgctcg gcgcgggacg catcacgctg ctgctgtggc tggccaccgc gctgctgctg
    19201 gcggtgctgg tgatgatccg caacgcctac ggtgcggtgt cggtgctggt caccgggggc
    19261 acgttcgtgc tggtgtcgtg gctcgcggga ccgcaggtgc aggcggcgtt cgcgtacgcc
    19321 gtggtgtggt tcctgctgct gggcggggtg cgtccggcgt tcgagctcca ggccaagcgg
    19381 cggcacgggg gcgccgggga ctcggacgcg gaccagttgt cccggctgac gcacgtgccg
    19441 gcggggctgt ggctgttcct cttccacgcg gtgtcggtgt gctcgttgct gggcgggggg
    19501 cgctggctgc tgggtctgtg accgggcggg ccggcgggtg accgggcggt gttccgcctg
    19561 gcgggcacgg aacggccggg ctcctcacct ccttataaag tggccccatg gccccgaatc
    19621 ccacgcacac cgccctctgg cccgccccgc acgcgagcgg agccgtcgac gcgacggtcc
    19681 acgtgcccgg gtccaagtcg gtcaccaacc gcgctctcgt cctcgccgcc ctcgcctccg
    19741 agccgggctg gctgcgccgc ccccttcgct cgcgcgacac gctgctgatg gcgggcgggc
    19801 tgcgcgcgat gggcgtggag atcgaggagg gcgtcggtcc cgacgggacg ggcgaggcct
    19861 ggcgtgtggt gccggccggt ctgcgcggcc cggccacggt ggacgtgggc aacgcgggca
    19921 cggtgatgcg cttcctgcct ccggtggcca ccctggcgga cggcccggtg cgcttcgacg
    19981 gcgacccgcg gtcctacgag cgtcccctga acggcgtcat cgacgcgctg cgccggctgg
    20041 gcgcccggat cgacgacgac gaccggggcg cgctgccgat gacggtgcac ggcgggggcg
    20101 cgctggacgg tggcacggtc gaggtggacg cctcctcgtc gtcacagttc gtcagcgccc
    20161 tgctgctgtc ggcgccgcgc ttcaaccagg gcatggaggt gcggcacacc ggcgcgacgc
    20221 tgccgtcgat gccgcacatc cggatgacgg tcgacatgct ccgcgcggtc ggcgcccagg
    20281 tcgacacccc cgagtcgggc ggcgagccga acgtctggcg ggtcaccccg ggcgccctgc
    20341 tcggccggga cctgacgatc gagccggacc tgtccaacgc gcagccgttc ctcgcggccg
    20401 cgctgatcac cggcggcagg atggtcatcc ccgactggcc cgcgcgcacc acccagcccg
    20461 gcgaccggct gcgggagatc ttcaccgaga tgggcggctc ctgcgagctg accgagtacg
    20521 ggctggtctt caccggctcc ggcacggtgc acggcatcga cgtggacctc ggcgaggtgg
    20581 gcgagctgac gccgggcatc gcggcggtcg cggccctcgc ggactccccg tcgaccctgc
    20641 ggggcgtggc ccatctgcgg ctgcacgaga cggaccggct ggccgcgctc accaaggaga
    20701 tcaacgagct gggcggcgac gtcaccgaga cggccgacgg cctgcacatc cgcccgcgcc
    20761 ggctgcacgg cggggtcttc cacacctacg aggaccaccg catggccacc gccggtgcga
    20821 tcatcggcct ggcggtcgac ggtgtgcaga tcgagaacgt ggcgaccacg gcgaagaccc
    20881 tgccggactt ccccgagctg tggaccggga tgctcggggc ataggggttc acgatgcgcc
    20941 gctacggcaa gcacaccgac gaggacgaca tccgctcccg ccccaaccgc aagggcaacc
    21001 ggccgcgcac ccacatcagg cccaagcacg aggacgccgc cgagggcatg gtgctcacgg
    21061 tcgaccgggg ccggctgacc tgcctc
//
