LOCUS       NZ_RAII01000001        25183 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1358444
            Orig. end                         :: 1383627
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25183
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25183
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25183
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15183](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15183)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(11..22)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.3"
                     /tool="antismash"
     misc_feature    140..154
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.08"
                     /tool="antismash"
     misc_feature    complement(142..153)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.84"
                     /tool="antismash"
     misc_feature    147..160
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            complement(302..1501)
                     /locus_tag="EBH12_RS37260"
     CDS             complement(302..1501)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006134534.1"
                     /locus_tag="EBH12_RS37260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional class I SAM-dependent
                     methyltransferase/NUDIX hydrolase"
                     /protein_id="WP_114872981.1"
                     /sec_met_domain="PCMT (E-value: 8.6e-05, bitscore: 21.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAEDTNTRAWQIYGRRQLAHAHTPPVPDRLDWTPWEGVGPGAEV
                     FGDLTGRRVLDIGSGAGHHAVHLAQAHGAHVTGIELSPTQHERAVSAHADVDGVEFVHA
                     DVTEYLAGAEPFDAAYAIGTLAFIDPHRSLPALRDGLRPGAPLVLSLLHTDLHGRGPSR
                     EVAPREEMILLRDDPPLPTQMWVLAPQLWEDLLTEYGFRVEAVGLFPHPDESASVVQQL
                     IRARRLPDRPARVSSRPRSTRAPAAHAAVGVGAILLGEQGILLGRHRHGTLELPGGSVE
                     AGESFEDAVIRELTEETGLVAHVEDVGLLGTLVDHVEDVLRVTVGALVHAWQGQPATQP
                     DESVGDWAWYPLDQLPHGLFVCSAQILTGWRPDLPIDHPPAHFTRFASGPVATPGNGPI
                     "
     gene            complement(1530..1733)
                     /locus_tag="EBH12_RS36180"
     CDS             complement(1530..1733)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EBH12_RS36180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_241563062.1"
                     /transl_table=11
                     /translation="MGLVFDGGRLTADQLDRIRLDPAEHDMWAVHDLATWQELMAPRAF
                     ARLDAVERARRGEGPAYLITHT"
     gene            complement(1775..2434)
                     /locus_tag="EBH12_RS06165"
     CDS             complement(1775..2434)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="EBH12_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_241563063.1"
                     /transl_table=11
                     /translation="MSDDTQQAISGVPSPAGADVAPEHHMHLLGRYYRQVEAGRKTIEV
                     RVATPNKLAVAVGDTVVFHDRDTGRELDVIVERIIPYPSFEDLLRSEDTARIDPGAPPG
                     ELLAALRGIYPPAKEALGVLALAFGHRPARPGRPMPMTAEEYARTVPHHTVYGCLYIRD
                     EHDRPIQLRSVYGSRLWQFPGGNLDAPGEDPLRTARREAIEETGLELALDTHRRCS"
     gene            complement(2568..3758)
                     /locus_tag="EBH12_RS36185"
     CDS             complement(2568..3758)
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016805 - dipeptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700236.1"
                     /locus_tag="EBH12_RS36185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M15 family metallopeptidase"
                     /protein_id="WP_241563064.1"
                     /transl_table=11
                     /translation="MVLRGNSASGKSSVAQGLRDHYGRGLAIVGQDVIRRNVLREHDTA
                     RGANIALLGRIACEALNAGFHVVLEGILYADRYGHMITSLVRDHRGVSHCYYLNVPLQA
                     TLVRHASKEDAAYLAHVTDSHLASWYRELDLLPDGLETVIPADSTLQDTVARILRETEL
                     APASPIPPPYKPSQGDAMNPLVLMSDPRVAAIPVRECGEPLVDVRDHGFRVDPRKHDPL
                     GAFAHVREGVLARLEHARSLLPAGTDLLFIEGYRPLTLQQRYFTEYRDELAAAHPDWTP
                     EQLHQGTSRYVSPPEIAPHSAGAAVDVTLVDQDGHELDLGTRVNASPEESDGACFTHAP
                     NLSDLARHHRTLLLTAMEGAGFTNYGTEFWHFSVADRYDALMRQEPHARYGPTELP"
     gene            complement(3830..4588)
                     /locus_tag="EBH12_RS06180"
     CDS             complement(3830..4588)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="EBH12_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_241563065.1"
                     /transl_table=11
                     /translation="MRRELDEEAGLSIAGLTPFGTEYASDDAGRTVPIAIYAGRWNGDP
                     RDLHLTEGVMLAWFAPDDLDRLRIAPTTRDLVRRHAAGLPTSTAPQSGLAPQEERRASP
                     HGAVLNVIGVHLYLERPDGTVLLGLRHPDSAFAPSTWHVLAGHCEQESAVACLIREAQE
                     EAGLHIERQDVELVHVVHHIDKAGDQPRMGLFFRARAWSGEPELREPDKCTQWRFWDPA
                     TLPDNLVPYTRVAIGKIQNGELYSETGWPA"
     gene            complement(4597..5507)
                     /locus_tag="EBH12_RS06185"
                     /pseudo=""
     CDS             complement(4597..5507)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046761.1"
                     /locus_tag="EBH12_RS06185"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVGRGELTDATWERIAPLLPGVDGRGRPWRDHRQVINGVLWRLRT
                     GAPWRDLPERYGPWQTAYERFARWEADGTWARLLEQVQVRDDSVGAVEWTVSVDSTISR
                     AH"
     misc_feature    complement(5514..5528)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.08"
                     /tool="antismash"
     gene            complement(5519..6244)
                     /locus_tag="EBH12_RS06190"
     CDS             complement(5519..6244)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389173.1"
                     /locus_tag="EBH12_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_114872980.1"
                     /transl_table=11
                     /translation="MPLSHDHIRTTVETYLARHPHEREQLGVLLDALKRPTDIASRTTF
                     TGHVTCGAIVLDPLGRVLHVLHLASGKALAPGGHAEPSDESLAGTALRELHEETGIPPQ
                     EVTPWPGYETMPFDIDIHDIDTNPGKGEPDHRHFDLRFLFRLHATNEVEVRLQEEEVGG
                     IEWRPVDRAASPSLREKLRKLPLQVEPETTNASALIYNDRGEYLLHLRDYFPGEIWEPG
                     MWSLLGGGREPQDATLGPV"
     misc_feature    complement(6222..6238)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.08"
                     /tool="antismash"
     misc_feature    6682..6691
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(6709..8649)
                     /locus_tag="EBH12_RS06200"
     CDS             complement(6709..8649)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008416914.1"
                     /locus_tag="EBH12_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_114872979.1"
                     /transl_table=11
                     /translation="MTSAVTQDQPPQPPKGTVPDDETQQASVREEEYLYRDESRLQAGS
                     QLTSRTMARRLPSLVRRSVQMAWRVDRGATVGLLVCQIGTGVLAALGLLAVTGTITALI
                     SAGDITERLWDAAPQLAVIAASTGLRALLGITVIWLTGRLRPVLGRAAELTMIEAALGA
                     ELAANNKPGYNDAYDIADRGAQVTPDLVEEAQDVLAATATLAAGATVLTVLHPLLLPLL
                     FLACLPQAAAYVRSARVLYLAGLETSGRRRMLGKLRWHMAYQESSEEMRACLAGPFLIG
                     RYRRLAASVNAAERKAANTGAWMGLAGAVAGGIASTAVWAALLWLLASGRMSLAAGGGA
                     VFALQTATGSVRGIINGGARLVRTGWYVQDWQNFLDNAHGQAMTDSRGTALVAAAPERF
                     EVRDVTYRYDGAPKDSLSNVSLHVRRGEIVALVGENGSGKTTLSRLLCGLLLPTEGDVA
                     WDHASTADLDPWRSWEHVALVPQKFTYLPLTMRDNITFGQGDTSDAALLAACQASGAAE
                     MLPGLRSGLNTLLTSEWFGGQQLSGGQWQRLVLTRAFHRKAALLVMDEPTAALDARAEH
                     RIFAGLRELAKDRAILLITHRLSNVAIADRIIVLDEGRIVQEGTYAQLTQQPGLFRTLW
                     ELQRRMSGDTS"
     gene            complement(8884..9996)
                     /locus_tag="EBH12_RS06205"
     CDS             complement(8884..9996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="EBH12_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_114872978.1"
                     /transl_table=11
                     /translation="MIPAIASRIPLVRRTKAPALPLKERINHLTGLTVAPAGASHHELV
                     ARACGVLNYAALIASDVGLPRLAEDLCWRQHQVFVNAGRLSGRVAVMSLMPLVNLARLE
                     TRAGHGELAYSLLHCLNDAARHRNKTDIDGRTVDLSTLTGTDEDHRAVCQELYVTLLVD
                     GARALAQIGRWTEAADAMAQHRGIGKRLLDGRQIKIMALMEQGLDQQARDLIDTTQPAE
                     PWEDAVALLLHAHCRTTDAPVPEADLDRTLNAAAQLLAHPDPPTAAFQTRTGLSALELD
                     RAGRHTAQILDALLSVARLDAYAARDALHHPNARSALGDQATNALTAVIAAAGLGAGAL
                     SAHDHEALTSAVGNAERELEGLLQADPDPG"
     gene            complement(10001..12046)
                     /gene="fxlM"
                     /locus_tag="EBH12_RS06210"
     CDS             complement(10001..12046)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="EBH12_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_114872977.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-15, bitscore:
                     55.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.7e-40, bitscore: 137.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDDENLPIPPATSWWHASVSFPAPHAGAARAVATALSGRRFHF
                     LRKDAGVRLRTEQPVPDLLDQLVADRVITGWTGGMYEPETHAFGGPEAMAVAHDMFCAD
                     SPAALAETGTPGVRERSVMLLSAMIREAGLDPFEAGDVYAQWAALRPPVTPPQGLALEQ
                     AVSAMRRLMNADAALRPDAEAGWAERVAAFEDAGRRLRRLAADGRLIRGIRGVIAHHAI
                     FAFNRAGVPADAQAATAWLGRHVAFSTGEGADVSTRKSASAEPSLPRMETTMTPVTDPN
                     QLREALAQRLAESGHLRSQAAIDAFRTTDRHAFLPGVDLESAYKEDAVPIKHDEDGEMI
                     SCISAPSIVATQLEQLGAQPGHKVLEAGAATGYNAALLGKIVSPGGQVWTLDVDQDLVA
                     GASKHLAVAGVDNATAVMADGAAGLPEHAPYDRIIFTVGAGDVPVKILDQLAPGGRLVL
                     PMRIRGSISRSFAFERDGETWKTVSCEMATFIPLRKGVCDDVYTLVPMAGEGNVRLETF
                     SEQDVDRDALCTVLDQQQTKLYTGVKFRQGSAWEWLYLYLACVLPNGLSRLPGQRPGFT
                     PHFGWGSMAALDGGSLAYLTIREGEDEQGRYWEVGVIGHGEDGAGLAERVVSETRAWDA
                     SGGNDAPEPGFRMAVADSRDRLTADDARFVVDKPYSRLVVDWARKG"
     gene            complement(12077..13147)
                     /locus_tag="EBH12_RS06215"
     CDS             complement(12077..13147)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326267.1"
                     /locus_tag="EBH12_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_114872976.1"
                     /sec_met_domain="LANC_like (E-value: 7.6e-29, bitscore:
                     99.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTVSRTQDLSEGALGMALLDIERRDLAAARRHLAQATVRGVS
                     TGSNASLFHGAPALEFVLARAHAAGDAVRSAVDRVVDARLAAAYRRQAAGVLPHLAEWD
                     LIRGLTGLAALLLTRRPIAPRLPDVLACLVVLAHPARGDGRMLPGWWSPVGPDGKEMAG
                     GHGNNGMAHGIAGPLAVLSLALRAGVSVPGQEEAVGTFATWLDRHGAHYWSTAAHLDAD
                     QPPKAEPARQSWCYGQPGIARAQQLAALALDDPARRRAAEDTVATILTDPLHLARITDS
                     TLCHGWAGLLTLTRAVAADSPAPARFTLIIQDLHRRLAADWERLPKPGLMEGRAGAQLA
                     LHATDTTGWTRALLFT"
     gene            complement(13144..15183)
                     /locus_tag="EBH12_RS06220"
     CDS             complement(13144..15183)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="EBH12_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_241563066.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.5e-19,
                     bitscore: 67.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-103,
                     bitscore: 343.7, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRHRPSMYEAVGQAMLRATVHMTEPVMPPWPTRTAPAEEWRAWL
                     STVWSDTAFRRTVSQASPRLSEQVQAIIDGRTPKVRRMRRAALSTARYAIRYARRSTPY
                     GLFAGVAPLDFAQAASVRIGDEHQAVARPESVSLEEMLSTWESDAARMADTEVCVNTLI
                     QQRDQHIYVPSEGDAEFRLALSPALRLVLDLARSPIGYRQLSDKLAAEFPAVSGTARDR
                     LLGELLRVRLLRSSLRAPATVADPTDVLPPAARARAAGLRTACDLRLDADVQLPAQVLT
                     EVETAATVLARLVTHPNGTPTWRRWIEQFSERYGENTAVPVEAATDPDRGVGFPAGFIT
                     ASEPPRPMLQRDRLLLELAGTAAAEGSRTVAVTGAMIEELEAAAGDQPQDLAPHLELAV
                     QVHATSVPALDRGDFRLRVLTVSRSAGSMTGRFWHLFPGTETAYANLPTVDPQAELAQF
                     SFHAGRVPADLLTRAPQALPRVVSVGEFRRPAPHVLFPRDLSVTVTDGRPQLVESATGK
                     PLELLAPTAINFLWNNYTPPMARFLAEISRAVSPQVTWFDWGAAWALPFTPALTYRRTI
                     LAAARWKIRSSVLPSRTAPLQQWADQLRAWRARFRVPERVLLAEDDQQLPLDLSRDVDL
                     DLLRAHVDASPFGIATLHEAPPPDAEGWIGGRAHSIVVPLARRS"
     misc_feature    complement(13936..13938)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14434..14436)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14464..14715)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EBH12_RS06220_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-21"
                     /identifier="RREFam001.1"
                     /label="EBH12_RS06220"
                     /locus_tag="EBH12_RS06220"
                     /protein_end="240"
                     /protein_start="156"
                     /score="67.6"
                     /tool="antismash"
                     /translation="VCVNTLIQQRDQHIYVPSEGDAEFRLALSPALRLVLDLARSPIGY
                     RQLSDKLAAEFPAVSGTARDRLLGELLRVRLLRSSLRAP"
     gene            complement(15272..15460)
                     /locus_tag="EBH12_RS06225"
     CDS             complement(15272..15460)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="EBH12_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_030862011.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.6e-15, bitscore:
                     55.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVQTERPTAPVQSDLATTTEADPFGLDITFIEGTPATETVLMC
                     STGDTCGSSCPSACTTS"
     CDS_motif       complement(15341..15460)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVQTERPTAPVQSDLATTTEADPFGLDITFIEGTPATE"
                     /locus_tag="EBH12_RS06225_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15272..15340)
                     /prepeptide="core"
                     /locus_tag="EBH12_RS06225_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-9.90"
                     /molecular_weight="1932.2"
                     /monoisotopic_mass="1930.8"
                     /core_sequence="TVLMCSTGDTCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVQTERPTAPVQSDLATTTEADPFGLDITFIEGTPATE"
                     /leader_location="[15340:15460](-)"
                     /alternative_weights="1950.2"
                     /alternative_weights="1968.2"
                     /alternative_weights="1986.2"
                     /alternative_weights="2004.2"
                     /alternative_weights="2022.3"
                     /alternative_weights="2040.3"
     gene            complement(15591..16058)
                     /locus_tag="EBH12_RS06230"
     CDS             complement(15591..16058)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491161.1"
                     /locus_tag="EBH12_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6082 family protein"
                     /protein_id="WP_114872975.1"
                     /transl_table=11
                     /translation="MKLTTAVLAAGTAVAFTTAVVGAARLKQDARHQTERNEAVLARNQ
                     LDWLAQMSTTPDLTKLWTPEGMDVEEYMQLLKANQLICMLSLRDRLGFVRSGHLPWYAA
                     QLMESDVCRRYWRRFGDLRAQEAEGDERAEQFTRVLDKAAKNHPQARPAAA"
     misc_feature    16072..16086
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.98"
                     /tool="antismash"
     misc_feature    complement(16078..16094)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    16080..16092
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            complement(16131..16625)
                     /locus_tag="EBH12_RS36190"
     CDS             complement(16131..16625)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143023.1"
                     /locus_tag="EBH12_RS36190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6624 domain-containing protein"
                     /protein_id="WP_121740281.1"
                     /transl_table=11
                     /translation="MPSHLSRRNVLLAGAAAGSALALSAAPAHAHRRPHRPFGRHGSPS
                     ARVTATTLYVHPRGAGDFTGAAILLERAVKSGDALIQHWAHLHDRALINNRHQQEYGTQ
                     LLLQADGIELCPLRAPESVDERRAGVGLPPIAVALESVRRRYTSDRHAEEAPAVALARA
                     A"
     gene            complement(16715..18046)
                     /locus_tag="EBH12_RS06240"
     CDS             complement(16715..18046)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976940.1"
                     /locus_tag="EBH12_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide lyase family 1 protein"
                     /protein_id="WP_121740282.1"
                     /transl_table=11
                     /translation="MNVHVWHGHARGAGVLAGCTVLVLALTGTAAQAHTPAHAHRDPAR
                     QTLPAGDGWASYGSGTTGGAAAEAAHVRTVTDWAQFTAALAEGGDAPRIIKVKGTIDAV
                     ADGCDALAVPGYDFDAYLETYAPGTWGLERDLTDEPDDSPEGLRRASAAHQDAVIKVNV
                     PSDTTIIGVGRDAAIKGASLQIKDVDNVIVRNLTLESPVDCFPQWDPTDGDRGNWNSEY
                     DTVVVHGATHVWLDHNTFTDGAHPDSAAPTHFGMLYQQHDGELDIVKGANHVTASWNVF
                     TEHDKTILIGNSDSESTAVGDRGRLKATFHHNLFEDLTERTPRVRFGQVDVYNNHFVAG
                     SGYGYSFGVGKESQLVAEHNAFTLPRGISPAKVLKRWNDSPLTARHNLVNGRPVDLIAV
                     HNAEIPEETLRSGAGWTPALRKAVHPAWAVPALVGLGAGAGRLR"
     gene            complement(18078..>18287)
                     /locus_tag="EBH12_RS06245"
                     /pseudo=""
     CDS             complement(18078..>18287)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004989710.1"
                     /locus_tag="EBH12_RS06245"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="rhamnogalacturonan acetylesterase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LRGPEATQAYFNWTDTKQDTTHFSPTGAIAVARLVARELPRIRVL
                     APHDVRRPAEEIPSSWITWPGAAA"
     misc_feature    complement(18238..18251)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(18363..19724)
                     /locus_tag="EBH12_RS06250"
     CDS             complement(18363..19724)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522180.1"
                     /locus_tag="EBH12_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_114873433.1"
                     /transl_table=11
                     /translation="MKISILGRSTGRGRRGRSAAAVALGAVLALTATACGDDGSGGAGA
                     EGDGKGKIVFWDNNGGVRTDIWKEIIADFEKANPDIEVQYVGIASTEYQSKVDTAIQGG
                     GMPDVGGISASMLAGFAAQGALEPLDERLEGSSLNGKLNKDMIESLRAAGGGDDQLYSV
                     PTSANNGVLYYRTDMFEKAGLEEPATWDRFFEAAEKLTDKGSNRFGYTIRGGAGSIAQA
                     LDAMYGQSGITSFWDSTGKKTTVNDPKNVQALEKYAALFKKVTPAADLNNDFTKMVAQW
                     DSGEIGMLNHNLGSYQDHVKALGVEKFRGIPQPVGPGGKRVQVSNPVDGIGLFKSSKNK
                     DAAWKFIEFAASAESNSKFNESAGQVPAHADAAKDAWIAKAEPTKLAADALSDGSTTIV
                     QLPYYLPDWNTVSKADNEPNFQKVLLGDMSAKAFLDGLAEQLNEAQAEWDEQMG"
     gene            complement(19721..21319)
                     /locus_tag="EBH12_RS06255"
     CDS             complement(19721..21319)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522181.1"
                     /locus_tag="EBH12_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase 43 family protein"
                     /protein_id="WP_114873434.1"
                     /transl_table=11
                     /translation="MSAAPDDPVYRNPVLDADWSDPDVIRVGDDFYLTASSFGRVPGLP
                     LLHSRDLVNWTLVGHALHRLEPEGEFAVPRHDCGVWAPSLRHHDGRFWIFWGDPDQGIF
                     QVNAPEIRGPWTRPHLVKAGKGLIDPCPLWDDETGEAYLVHAWARSRSGVKNRLTGHRM
                     HPHGTELLDEGKVIVDGDRLPGWFTLEGPKLYRHDGWFWILAPAGGVETGWQGAFRSRA
                     FFGPYEEKVVLEQKDTDVNGPHQGGWVRTPSGEDWFLHFQQRGAYGRVVHLQPMRWDGG
                     GGWPVIGDHGAPVAEHRRPDLPAQPSAAPATDDDFPGGRPGRQWQWTANPRDGWATHHF
                     ADGLRLTCVRTPDAHDLRALPNVLTQRLPGAPCTVEVDLRLDDGEPGARAGLAVLGDAY
                     SWIGLERGPDGAVGLVHRFAETSAMGAPPTPSGQWGRERDAAPPRPAPGGRARLRVDIG
                     AGARCRFSYDTGDDAGDGAGEGFRPSGQVFAATPWRWVGALLGLVALAPTGQGHAGTAT
                     FTQFRIRIQEKRADR"
     gene            complement(21316..22161)
                     /locus_tag="EBH12_RS06260"
     CDS             complement(21316..22161)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132728.1"
                     /locus_tag="EBH12_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PmoA family protein"
                     /protein_id="WP_114873435.1"
                     /transl_table=11
                     /translation="MTGNDSVVLRVAGRPVARYVTRPELPARLSPRPYLHPVTTLAGTA
                     VTELSPADHAHHLGVGVAVPDVEGFNFWGGRTYVRDRGPTELDNHGAQRHTAYHRREAD
                     GFTEELRWTAAPGELLRERRTVTATALTDGAWALDLTFALTNVSGRPLSVGSPATNGRP
                     GAAYGGFFWRARKEDTEPEVFTAAADGTDAVHGRTADWVALAGSTWTLVLAAATEATRR
                     DPWFVRTEEYPGVGSSLAHDARLPVPPGETVERRVVTVVADGRLGREDAGALVTKAVTA
                     "
     gene            complement(22158..23342)
                     /locus_tag="EBH12_RS06265"
     CDS             complement(22158..23342)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004932890.1"
                     /locus_tag="EBH12_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_234309873.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.4e-11, bitscore:
                     43.8, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 5.1e-10,
                     bitscore: 38.0, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPRTMTRTPLPVVLAGARGHGRRHVDNIRRLAAKGLVRLAGIC
                     ELTPLTEDEFGGELPEQSADLGALLDSTGARAAVICTPIPTHTALALTAAERGVHLLLE
                     KPPAPSYAAFRRMADGVAAAGVACQIGFQSLGSHAVPAIRDLIAEGAVGRVTGIGGAGA
                     WVRPEAYFRRAPWAGRRRLDGADVVDGALTNPLAHAVATALALAGSTRAEDVAGIETEL
                     LRANDIESDDTSCVRVTTVQGGSVTVAATLCAERADEPYVVVHGTSGRITFWYKQDRVL
                     LQRADHGPEELRFDRTDLLENLVAHLRDGTELLVTPDDTGAFMQVVEAIRTAPDPEPLP
                     DDAWRRVPGEDRRVVPGIDALVAAAADRLCLYSELGAPWARPAHHHLPEEVSTR"
     gene            complement(23339..>24160)
                     /locus_tag="EBH12_RS06270"
                     /pseudo=""
     CDS             complement(23339..>24160)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976934.1"
                     /locus_tag="EBH12_RS06270"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="RRRSWDEAPRWQIYLPLGIYLVFTLIPFYWILLFALRPAGSTSLV
                     PWPMTTAHFEKVWTDRGFGTFFQNSVLVGVATLFMTTLVALAGGYALARFDFRVKRGFM
                     LALLCSQFVPGALLLVPLFEIFAELRMINSLGSVIIAETVFQLPLSMILLSNFIKNVPY
                     SLEEAAWVDGCDRFRAFRVVVLPLLRPGLIAVGSFAFVHSWNHFLFALMFLNNQEKQTV
                     PVGLNTLMSADSVDLGALAAGGIIAAVPVVIVFAFIQKWLITGFSAGAVKG"
     gene            <24193..24681
                     /locus_tag="EBH12_RS06275"
                     /pseudo=""
     CDS             <24193..24681
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131458.1"
                     /locus_tag="EBH12_RS06275"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="AGMSPAALYIHYKTKEELLHRISRIGHEKALDILRTASRGEGTAT
                     ERLADAVSSFVRWHARGRTTARVVQYELDSLGPDARAEIVGLRRQVDAEVRGIVEDGVR
                     SGEFDVPDVPGTTLAVLSLCIDVARWFNVDGPRTPEEVGALYADLVLRMVGAENAGTA"
     misc_feature    24237..24251
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.04"
                     /tool="antismash"
     gene            complement(24678..25139)
                     /locus_tag="EBH12_RS06280"
     CDS             complement(24678..25139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570401.1"
                     /locus_tag="EBH12_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MaoC family dehydratase"
                     /protein_id="WP_048459097.1"
                     /transl_table=11
                     /translation="MAEPRIFTSVDDLKAAVGEQLGYTDWLEIDQKRIDLFAEATGDHQ
                     WIHVDPEKAAAGPFGTTIAHGYLTLSLLPLFGPQLLSVEGVRMGVNYGTNKVRFPAPVP
                     VGSRLRATARISAVDEVSGGVQVATAFTVEREGGDKPVCVAESVARYYL"
     misc_feature    25134..25144
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
ORIGIN
        1 tgaacggctc gacagcgttt tccagcacgc ccgcacgctc tgaaccacac ccatagccgc
       61 agggacttcg aggatctcgc gcgcagcacc agccgctacc gtccaggacg gcaacctcat
      121 cccatcacga gcccgaagtt ggagatcttt ttcccaagaa gatctggaag gacggaggcc
      181 cttcccgcgc gccctcgtgc tcctcggcga atacccagag ttccgcgagt acacccgcgc
      241 ccactttgtc tccttcgacg ggaaggctga ggtggcgcga caggtacgtc ggtgccggcg
      301 ttcagattgg gccgttgccc ggcgtggcca ctggtccgga tgcgaaacgc gtgaagtgcg
      361 cgggcgggtg gtcgatgggc aagtcgggtc gccagccggt gaggatctgg gcgctgcaca
      421 cgaacaggcc gtgggggagc tgatcgagcg ggtaccacgc ccagtcgccg acgctctcgt
      481 ccggctgtgt ggccggctgc ccttgccagg cgtggacgag cgcgccgacg gtgacccgca
      541 ggacatcttc gacgtggtcg acgagcgtgc ccaggagccc tacgtcctcg acgtgagcga
      601 ccagcccggt ctcctcggtg agttcgcgga tcaccgcgtc ttcgaaggat tccccggcct
      661 ccacactgcc gccgggcagt tcgagggtgc cgtggcggtg ccggcccagc aggatgccct
      721 gctcgccgag caggatcgct ccgacgccga cggccgcgtg ggcggccggg gctcgggtgc
      781 tgcgggggcg gctggagacg cgcgccggcc ggtcgggcag gcgccgggcg cggatgagct
      841 gctggacgac cgaggcgctc tcgtcggggt gcgggaacag gccgacggcc tcgacacgga
      901 agccgtactc ggtgagcagg tcctcccaca gctgcggtgc cagaacccac atctgcgtcg
      961 gcaggggcgg gtcgtcgcgc agcaggatca tctcctcgcg cggcgccact tccctggacg
     1021 ggccgcggcc gtgcaggtcg gtgtgcagga gcgagaggac cagaggagcg ccgggacgca
     1081 gtccgtcgcg cagtgccggc agcgagcggt gcgggtcgat gaaggcgagc gtcccgatcg
     1141 cgtacgcggc gtcgaacggc tcggctccgg ccaggtactc ggtcacgtcc gcgtgcacga
     1201 actcaacgcc gtccacgtcc gcgtgggcgg agacggcacg ttcatgctgg gtgggggaca
     1261 gctcgatgcc ggtgacatgg gctccgtgag cctgggcgag atggacggcg tggtgaccgg
     1321 ccccggagcc gatgtccagg acgcggcggc cggtgaggtc accgaagact tctgctcccg
     1381 gtccgactcc ttcccagggc gtccagtcga gccggtcggg gacgggcggg gtgtgggcgt
     1441 gggccagttg gcgccggccg tagatctgcc aggcccgggt gttggtgtcc tcggcgggca
     1501 cggttgcctc ctgggtggag tgttgggggt caggtgtgtg tgatcaggta ggcggggccc
     1561 tcgccgcgcc gggctcgttc gacggcgtcg aggcgggcga aggcgcgcgg cgccatcagc
     1621 tcctgccagg tggcgaggtc gtggacggcc cacatgtcgt gctcggcggg atcgaggcgg
     1681 atccggtcga gctggtcggc ggtcagccgg cctccgtcga agacgagccc caccttgttc
     1741 agcggcagcc ggggtccggc gtgcaggaag tgcgtcagga gcagcggcga tgtgtgtcta
     1801 gagcgagttc gaggccggtc tcctcgatgg cctcgcgccg ggcggtccgc agggggtcct
     1861 cgcccggggc gtccaggttg ccgcccggga actgccagag tcgtgagccg tagaccgagc
     1921 ggagctggat gggccggtcg tgctcgtcgc ggatgtagag gcagccgtac accgtgtggt
     1981 gggggacggt ccgcgcgtac tcctcggccg tcatcggcat ggggcgtccg ggccgggcag
     2041 ggcggtggcc gaacgcgagg gcgagaacgc cgagggcctc cttggccggc gggtagatgc
     2101 cgcggagggc ggcgagcagc tcgccgggcg gcgcgcccgg gtcgatgcgc gcggtgtcct
     2161 ccgagcggag caggtcttcg aaggaggggt aggggatgat tcgctccacg atgacgtcga
     2221 gttcccgccc ggtgtcccgg tcgtggaaga cgaccgtgtc gccgaccgcg acggcgagct
     2281 tgttcggggt ggccaccctc acttcgatcg tcttgcggcc tgcttccacc tgccggtagt
     2341 accgcccgag caggtgcatg tggtgctcgg gcgcgacgtc tgcgcccgct gggcttggga
     2401 cgcctgaaat cgcctgctgg gtgtcgtcag acattcgtgc ctccgttcga tgcgttccgt
     2461 ccgtcgcggt cgtggagtcg cgaccgtcca cggagcggtg gccgcgttcc tgcctgcctg
     2521 gctgggggcg gatgcgtggc gaggaagtgg acgagtccgc tgccgtgcta aggcagttcg
     2581 gtcggtccgt agcgcgcgtg cggctcctgc cgcatcagcg cgtcgtaccg gtctgccacc
     2641 gagaagtgcc agaactccgt cccatagttc gtaaaacccg cgccctccat ggcagtgagc
     2701 agcagcgtgc gatggtggcg cgcgagatcg ctgaggttcg gagcatgcgt gaagcaggcc
     2761 ccgtcgctct cctccgggga ggcattgaca cgggtgccga gatcgagttc gtggccgtcc
     2821 tggtcgacga gggtcacgtc cacggccgcg cccgcggagt gaggcgcgat ctctggcggc
     2881 gacacgtacc ggctggtgcc ctggtgcagc tgctcaggtg tccagtcagg gtgggcggcg
     2941 gccagctcgt cgcggtactc ggtgaagtag cgctgctgga gggtaagcgg ccggtatccc
     3001 tcgatgaaca gcaggtcggt gccggcgggc aggagcgagc gggcatgctc cagccgggcc
     3061 aggacgccct cgcggacgtg ggcgaacgcg cccagaggat cgtgcttgcg ggggtcgacg
     3121 cggaatccgt ggtctcgcac gtcgacgagg ggttccccgc actcacgcac cgggatcgcg
     3181 gcgacgcgcg gatcggacat caacaccaga gggttcatcg cgtctccctg cgacggcttg
     3241 tacggcggcg ggatggggga ggcgggggcc agctcggtct cgcgcaggat gcgcgcgacg
     3301 gtgtcctgca gggtgctgtc ggccgggatc acggtctcca gaccgtcggg cagcagatcc
     3361 agctcgcggt accaggaggc gaggtggctg tcggtgacgt gcgccaggta tgcggcatcc
     3421 tccttcgacg cgtgccggac caacgtcgct tgcagcggca cgttgaggta gtagcagtgg
     3481 gagacgccgc ggtggtcccg gacgagcgac gtgatcatgt ggccgtagcg gtcggcgtac
     3541 aggatccctt cgagcaccac gtgaaagccg gcgttcagcg cttcgcatgc gatcctgccc
     3601 agcagggcga tgttggcgcc gcgcgcggtg tcgtgttccc ggagcacgtt ccggcggatc
     3661 acgtcctggc cgacgatcgc gagtccgcgg ccgtagtgat ctcgcagacc ctgggccaca
     3721 ctcgacttgc ctgacgccga gtttccgcgg agcaccacga ggcgggtgtc cgcacggccg
     3781 accgcagtcg cagtgggtgc acggcggtgt gtgccgttgg gggtgctggt catgcgggcc
     3841 agcccgtctc gctgtacagc tccccgttct ggatctttcc gatggccacc cgggtgtagg
     3901 ggacgaggtt gtcggggaga gtggcggggt cccagaatct ccactgggtg cacttgtccg
     3961 gctcacgcag ttctggctcg ccgctccagg cgcgggcgcg gaagaacagg cccatccggg
     4021 gttggtcccc ggccttgtcg atgtggtgga cgacgtggac gagttcgacg tcctggcgct
     4081 cgatgtgcag gccggcttcc tcctgtgcct ccctgatcag gcaggcgacg gcgctctcct
     4141 gctcgcaatg gccggccagg acgtgccagg tggacggcgc gaacgcggag tcggggtggc
     4201 gcagcccgag cagcaccgtc ccgtcaggcc gctccagata gaggtggacg ccgatgacgt
     4261 tgaggaccgc gccgtgcggc gaagcccggc gctcctcctg cggtgcgagc ccgctctgcg
     4321 gcgcggtgct ggtggggagg ccggcggcgt ggcgccgtac gaggtcgcgg gtggtgggtg
     4381 cgatacgcag gcggtcgagg tcgtcgggag cgaaccaggc cagcatcacc ccttccgtca
     4441 ggtggaggtc acgagggtcg ccgttccagc gcccggcata gatggcgatg ggcacggtcc
     4501 tgccggcgtc gtccgaggcg tactcggtgc cgaacggggt taggccggcg atgctgaggc
     4561 cggcttcctc gtccagctca cgtcgcaccg tgtgttctag ggcctgtctg acaaaggatc
     4621 ttggttgggt tcgcggagcc agaggatgag tgaggcgagg tggactccgg ccttgtagcg
     4681 ggtggcgagt ttgtcgaagc gggtggcgat cgcgcggaac tgcttgaggc ggttgaagca
     4741 gcgctcgacc acgttgcggg ccttgtaaag ctcacggttg aaggccggcg gcctgccgcc
     4801 ggccttccct cgccgcaggc ggttggcctt ctggtccgcc cgctccggga tcaccgcccg
     4861 gatgcctctg cgtcgcaggg actggcggat cgcccgggac gaatacgcct tgtccgcgac
     4921 gaccgcatcg ggcctgaggc gggggcgccc ggcgccggtc cggggcactc tcagatcgtc
     4981 catgaccgtg tcgaagacgg tggagtcgtt gacgttgccg ggcgtgacga cgacagccag
     5041 gggcaggccc cggccgtcgc aggcgaggtg gatcttggtg gtcagcccgc cgcgggaccg
     5101 gcccagcgcc tggccagccg acggacatgc cggatcttcc agttcgtccc ccgccgccgc
     5161 ccctttttgc gggcaccagc ggcgtgctaa tgagcccggc tgatcgtgga gtcgaccgac
     5221 accgtccact ccacggctcc gacggagtcg tcgcgaacct ggacctgctc gagcaggcga
     5281 gcccaggttc cgtccgcctc ccagcgggcg aaccgttcat aggccgtctg ccacggccca
     5341 tagcgttccg gcaggtcacg ccacggagcc cccgtccgca accgccacaa caccccattg
     5401 atcacctgcc ggtgatcccg ccacggacga ccccgtccgt caacacccgg cagcaggggc
     5461 gctatccgct cccacgtcgc atccgtcagc tcaccccgac ccaccacaag atcaattatc
     5521 agacaggtcc tagggtggcg tcctggggct ctcggccgcc gcccagcagg gaccacatgc
     5581 ccggctccca gatttcgccg gggaagtagt cgcgcaggtg gagcaggtac tcgccgcggt
     5641 cgttgtaaat cagggcggag gcgttggtcg tctccggttc gacctggagc gggagtttgc
     5701 ggagtttctc gcgcagggaa ggggaggccg ctcggtccac gggccgccac tcgatgccgc
     5761 cgacctcctc ttcctgcagc ctcacctcca cctcgttcgt ggcgtgcagg cggaagagga
     5821 accggaggtc gaagtgtcgg tggtcgggtt cgcctttgcc cgggtttgtg tcgatgtcgt
     5881 ggatgtcgat gtcgaacggc atcgtctcgt agccgggcca cggcgtgacc tcctggggcg
     5941 ggattccggt ctcctcgtgc agctcccgta gcgccgtccc ggccagggac tcatctgagg
     6001 gctcggcgtg tccgccgggg gcgagagcct tcccgcttgc caggtggagc acgtgcagga
     6061 cgcggccgag cgggtcgagg acgatcgcgc cgcaggtgac atgtccggtg aaggtagtgc
     6121 ggctggcgat gtcggtggga cgtttaaggg catccaaaag gacgccgagc tgctcgcgct
     6181 cgtgagggtg gcgcgcgaga taggtctcga cggtggtgcg gatgtggtcg tgcgacaacg
     6241 gcatggggct acctacctca gagggcgtgg agcgggacgg gtcggggcag ggttcgggtc
     6301 agctcagccg catcccctcc gccgggacct ccttgatggc ggcggcgcgg gcgacgggca
     6361 ggccccacca cttgcgtgcg gtgtccaccg cgagctgggc ttgccgtgcg ccgggtgggc
     6421 cccagcccgg caggaacggc tgcctgggtg ggtgtggcga ggaggcgggt tcggcaggtg
     6481 acgtgcgggt gtttgccggg ttcgacgacg cttccgggca gtagccatga gtcgtcctcg
     6541 tggtaggtgg gatgcaccag caggacccgg ctgacttcgg tagccggtgg agtcgtcacg
     6601 acagtccttc ggggttggtg cggcgggttc ggacgtcggg cgaagggagc attgggagcg
     6661 ggttggtgtc tctgactggc agaaggcggc ctcgcgcgaa cggggtgatc aggaggtgtc
     6721 gccgctcatc cggcgttgca gttcccacag ggtccggaag agccctggct gctgggtgag
     6781 ctgggcgtag gtgccttcct ggacgatccg gccctcgtcc aggacgatga tccggtcggc
     6841 aatggccacg ttgctcaggc gatgagtgat cagcaggatg gcgcggtcct tggccagttc
     6901 gcgcaatccg gcgaagatcc ggtgctcggc gcgggcgtcg agggcggccg tgggctcgtc
     6961 catcaccagc agcgccgcct tccggtggaa cgcgcgggtg aggaccaggc gttgccactg
     7021 cccgccggag agctgctgac cgccgaacca ctcgctggtc agtagcgtgt tcaggccgga
     7081 gcgcaggccc ggcagcatct ctgccgcgcc ggacgcctgg caggcggcga gcagggccgc
     7141 gtcgctggtg tcgccctggc cgaaggtgat gttgtcgcgc atcgtcagcg gcaggtaggt
     7201 gaacttctgc ggcaccagcg cgacatgctc ccacgatcgc cacgggtcca ggtccgcggt
     7261 ggaggcgtgg tcccaggcca cgtcgccctc ggtgggcagc agcagtccgc acagcaggcg
     7321 cgagagggtc gtcttgccgg agccgttctc cccgaccagc gccacgatct ccccgcgccg
     7381 cacgtgcagg gagacgttgc tcaggctgtc cttgggggcg ccgtcgtagc ggtaagtgac
     7441 gtcgcggacc tcgaagcgct ccggggccgc ggccacgagg gcggtgccgc gggagtcggt
     7501 catggcctgg ccgtgggcgt tgtcgaggaa gttctgccag tcctggacgt accagccggt
     7561 gcgcacgagg cgggctccgc cgttgatgat gccgcgcacc gagccggtgg cggtctggag
     7621 ggcgaagacg gcgccgccgc cggccgccag gctcatccgg ccggaggcca ggagccacag
     7681 cagcgctgcc cacaccgcgg tcgaggcgat gccgccggcc acggctccgg ccagacccat
     7741 ccaggcgccg gtgttggcgg ccttgcgctc ggcggcgttg accgaggcgg ccagccgccg
     7801 gtaccgcccg atcaggaagg gaccggccag gcaggcgcgc atctcctcgc tggactcctg
     7861 ataggccatg tgccagcgca gcttgcccag catgcggcgc cgcccggagg tctccagccc
     7921 ggcgaggtag agcacgcggg cggagcggac gtaggcggcg gcctgcggca ggcacgcgag
     7981 gaagagaagg gggaggagca gggggtgcag gacggtcagg acggtggcgc cggccgcgag
     8041 cgtggcggtc gccgcgagga catcttgggc ttcttcgacg aggtcggggg tgacctgggc
     8101 tccgcggtcg gcgatgtcgt aggcgtcgtt gtagccgggc ttgttgttgg cggccagttc
     8161 cgcgccgagc gcggcctcga tcatcgttag ttccgcggcc cggccgagga ccgggcgcag
     8221 ccgtccggtc agccagatga cggtgatgcc cagcagcgcg cgcaggcccg tggaggcggc
     8281 gatgacggcc agctgtgggg cggcgtccca cagccgctcc gtgatgtcac ctgcggagat
     8341 cagggcggtg atcgtgcccg tgacggccag gaggccgagg gccgcgagga cgccggttcc
     8401 gatctggcac accagcaggc cgacggtcgc accgcggtcc acgcgccagg ccatctgcac
     8461 cgagcgccgc acgagcgagg gcaggcgccg tgccatggtg cgggaggtca gctgcgagcc
     8521 ggcctggagc cttgactcgt cgcggtagag gtactcctcc tctcgaacac tggcctgttg
     8581 cgtctcgtcg tccggcacgg ttcctttggg tggttgcggc ggctggtcct gcgtaacggc
     8641 cgaggtcatc gttcccccta ggacggtcgc tgcggctgag tcgtgaggtc taacgacgct
     8701 gctgcgatat cgaacacacg tcattcggtc gtgctgtgaa gcctgctgtt ccctgcgtct
     8761 gcggacctcg caggcgcccg atccctggtc tggcttggag tggctgcggg caggaaatgg
     8821 ccgaaacgcc gacaccgcca aaccgtgtgg gcggtaagcc ggggcaccac gggttggccc
     8881 ctcctatccg ggatccggat cggcctgcag cagcccttcc agttccctct cggcgttgcc
     8941 gaccgcgctt gtcagggctt cgtggtcgtg tgcggacagg gcgccggctc ccagtccggc
     9001 cgcggcgatc accgcggtca gcgcgtttgt cgcctggtcg cccaaggctg accgggcgtt
     9061 ggggtgatgc agagcgtctc gtgctgcgta ggcgtcgagt cgggcgacgc tgaggagggc
     9121 gtcgagtatc tgggcggtat ggcgtccagc acggtccagc tccagggctg acaggcccgt
     9181 ccgggtctgg aaagcggcgg tcggcggatc ggggtgggca aggagctggg cggctgcatt
     9241 cagggtgcgg tcgaggtcgg cttcggggac gggggcgtct gtggttcggc agtgggcgtg
     9301 caggaggagg gcgacggcgt cttcccaggg ctcggcgggc tgggtggtgt cgatcaggtc
     9361 gcgggcctgc tgatccaggc cctgttccat gagggccatg attttgatct gtcggccgtc
     9421 gaggagccgt ttgccgatgc cgcggtgctg ggccatggca tcggcggcct cggtccaccg
     9481 cccgatctgg gcgagggcgc gggcgccgtc cacgagcagg gtgacgtaca gctcctggca
     9541 taccgcacgg tggtcctcgt ccgtgccggt cagggtcgag aggtcgacgg tgcgaccgtc
     9601 gatgtcggtc ttgttccggt gccgggcggc gtcgttgagg cagtgcaaca agctgtaggc
     9661 gagttcgccg tggcctgcgc gggtctccag ccgggcgagg ttgacgagcg gcatcagcga
     9721 catgacggcg acccgtccgc tgaggcgtcc ggcgttgacg aagacctggt gctggcgcca
     9781 gcacagatcc tcggccaggc ggggcaggcc gacgtcggag gcgatgagcg ccgcgtagtt
     9841 gaggaccccg caggcgcggg ccaccagttc gtggtggctc gcacctgcgg gcgcgacggt
     9901 cagcccggtg aggtggttga tgcgctcctt caaggggagc gcgggtgcct tggtgcggcg
     9961 gaccaggggg atgcggctgg ctatcgcggg gatcatcggc tcagcccttg cgcgcccagt
    10021 cgacgaccag tcgactgtag ggcttgtcga cgacgaagcg ggcgtcgtca gccgtcagcc
    10081 ggtcacgtga gtccgcgacg gccatccgga agcccggttc gggggcgtcg ttgccgccgc
    10141 tggcgtccca ggcgcgggtc tcgctcacca cacgctcggc aaggccggcg ccgtcctcgc
    10201 cgtggccgat cacgccgacc tcccagtacc ggccctgctc gtcctcgccc tcgcggatgg
    10261 tcaggtacgc gagcgatccg ccgtcgaggg cggccatgga gccccacccg aagtgcgggg
    10321 tgaacccggg gcgctggccc ggcaggcggg agaggccgtt gggcagcacg caggccagat
    10381 acaggtacag ccactcccag gccgagccct ggcggaactt caccccggtg tagagcttgg
    10441 tctgctgctg gtcgaggacg gtacacaggg cgtcgcggtc gacgtcctgc tcgctgaacg
    10501 tctccaggcg cacgttgccc tcgccggcca tcggcacgag ggtgtagacg tcgtcgcaga
    10561 cgcccttgcg cagcgggatg aaggtggcca tctcgcagga gacggtcttc cacgtctccc
    10621 cgtcgcgttc gaaggcgaag gagcgggaga tgctgccgcg gatgcgcatc ggcagaacca
    10681 gacgtccgcc gggggcgagc tggtcgagga tcttcacggg gacatcgccg gcgccgacgg
    10741 tgaagatgat ccggtcgtag ggagcgtgct cgggcagccc ggccgcgccg tcggccatca
    10801 ccgcggtggc gttgtcgacg cccgccacgg caaggtgctt gctcgcgccg gcgacgaggt
    10861 cctggtcgac gtcgagcgtc cacacctgcc cgccggggga gacgatcttg ccgaggagag
    10921 cggcgttgta gccggtggcg gctccggctt ccaggacctt gtgacccggc tgggcgccga
    10981 gttgttcgag ctgggtggcg acgatggacg gcgcggagat gcaggagatc atctccccgt
    11041 cctcgtcgtg cttgatcggg accgcgtcct ccttgtacgc gctctccagg tcgacgccgg
    11101 gcaggaaggc gtgccgatcg gtggtgcgga aggcgtcgat ggccgcctgg ctgcgcaaat
    11161 ggccgctttc ggcgagccgt tgggcgaggg cttcgcgcag ctggttgggg tcggttacgg
    11221 gtgtcatggt ggtctccatt cgagggaggc taggttccgc ggaggcggac ttgcgggtag
    11281 acacgtcagc tccttctccg gtggagaagg cgacgtgacg accgagccac gcggtggctg
    11341 cctgcgcgtc ggcaggcacg cccgcacggt tgaacgcgaa gatcgcgtga tgggcgatga
    11401 cgccccggat tccgcgtatc agtcggccgt cggcggcgag ccggcgcaga cggcggccgg
    11461 cgtcctcgaa cgcggcgacg cgctcggccc agccggcctc cgcgtcgggg cgcagggcgg
    11521 cgtccgcgtt catcagccgc cgcatcgcgg aaacggcctg ttcgagggcg aggccctggg
    11581 gcggggtgac ggggggacgc agggcggccc actgggcgta cacgtctccg gcttcgaacg
    11641 ggtccagccc ggcctcgcgg atcatcgcgg acagcagcat cacgctgcgc tcgcggacgc
    11701 cgggggtgcc ggtctcggcg agcgcggccg ggctgtcggc gcagaacatg tcgtgcgcga
    11761 cggccatggc ttcgggaccg ccgaaggcat gggtctccgg ctcgtacatc ccgcccgtcc
    11821 aaccggtgat cacgcggtcg gcgacgagct ggtccagcag gtcaggcacg ggctgttcgg
    11881 tgcgtaggcg cacgccggcg tccttgcgca ggaagtggaa gcggcgaccg gacagcgcgg
    11941 tcgccacggc ccgggcggcg cccgcgtgcg gggcgggaaa ggacacggag gcgtgccacc
    12001 aggacgtggc cggagggatc ggcaggttct cgtcgtcgaa gtccatgaga agtcatctcc
    12061 ttgcgaggcg gcagggtcag gtgaacagga gggcgcgggt ccagccggtg gtgtcggtgg
    12121 cgtgcagggc gagttgggct ccggcgcggc cttccatgag cccgggtttg ggcaggcgct
    12181 cccagtcggc ggccagccgt cggtgcaggt cctggatgat gagggtgaag cgtgcgggtg
    12241 cggggctgtc agcggcgacc gcgcgggtga gggtcagtag gccggcccag ccgtggcaga
    12301 gggtcgagtc ggtgatgcgg gcgaggtgca gcgggtcggt caggatggtc gcgacggtgt
    12361 cctcggccgc ccgacggcgg gcggggtcat cgagggcgag cgcggcgagc tgctgagcgc
    12421 gggcgatgcc gggctggccg tagcaccagg actggcgggc cggttccgcc ttgggcggct
    12481 ggtcggcgtc caggtgtgct gcggtggacc agtagtgggc gccgtgccgg tcgagccagg
    12541 tcgcgaacgt gccgacggcc tcctcctgtc cggggacgct gacgccggcg cgcagggcga
    12601 gggagagcac ggccaggggc cccgcgatgc cgtgggccat gccgttgttg ccgtgcccgc
    12661 cggccatttc ctttccgtcc gggccgaccg gcgaccacca cccgggcagc atccggccgt
    12721 caccgcgggc ggggtgcgcg agcacgacga ggcaggcgag cacgtcgggc agccggggcg
    12781 cgatcgggcg gcgggtcagc agtagtgcgg cgagtccggt caggccgcgg atgaggtccc
    12841 attcggcgag gtggggcagc acgccggccg cctgacggcg gtaggcggcg gcgagccggg
    12901 cgtccacgac gcggtcgacg gccgagcgga cggcgtcacc agctgcgtgg gcgcgggcca
    12961 ggacgaactc cagagcgggt gcgccgtgga agagactggc gttgctgccg gtactcaccc
    13021 cccgaacggt ggcctgggcg aggtggcggc gggcggcggc caggtcccgg cgctcgatgt
    13081 cgagcagggc catccccaga gcaccctcgg acaggtcctg cgtacgggac acggtcgtcg
    13141 tggtcatgag cgcctggcca gggggacgac gatgctgtgg gcccggccgc cgatccaccc
    13201 ctcggcgtcc ggcgggggcg cttcatgcag ggtggcgatg ccgaaggggc tggcgtccac
    13261 gtgcgcgcgc aggaggtcca gatcgacgtc gcggctgagg tcgaggggca gctgctggtc
    13321 gtcctctgcg agcaggaccc gctccggcac ccggaaccga gcacgccagg cgcggagttg
    13381 atccgcccac tgctgaagtg gtgcggtacg ggacggcagc acgctgcttc ggatcttcca
    13441 ccgcgcggcg gcgaggatgg tgcgtcggta agtgagggcc ggggtgaagg gcagggccca
    13501 ggcggcgccc cagtcgaacc aggtcacctg cggggagacg gcccggctga tctcggcgag
    13561 gaagcgggcc atcggcgggg tgtagttgtt ccacaggaag ttgatggcgg tgggagccag
    13621 cagctccagc ggcttacccg tcgcggactc cacgagctgg ggacggccgt ccgtgacggt
    13681 gaccgacagg tcgcggggga agaggacgtg cggggcgggg cggcggaact cgccgacgct
    13741 gacgacgcgg ggcagggcct ggggcgcgcg ggtgagcagg tcggccggca cccgcccggc
    13801 gtggaaggag aactgagcga gttccgcctg cggatcgacg gtgggcaggt tcgcgtacgc
    13861 cgtctcggtg ccggggaaca ggtgccagaa ccgtccggtc atcgaaccgg ccgagcggga
    13921 gaccgtcagc acgcgtaacc ggaaatcgcc ccggtccagg gccggaacgg aggtggcgtg
    13981 gacctgcacg gccagttcga ggtggggcgc caagtcctgg ggctggtcgc cggccgctgc
    14041 ctccagttcc tcgatcatcg ccccggtcac cgcgacggtg cggctgcctt cggcggcggc
    14101 ggtaccggcc agctccagca gcagacggtc acgctgcaac atcggtcgag gcggttcact
    14161 tgccgtgatg aacccggccg ggaaccccac tccccggtcg gggtccgtgg ccgcttccac
    14221 cggcaccgca gtgttctcgc cgtagcgctc ggagaactgc tcgatccacc gccgccaggt
    14281 cggtgtcccg ttcggatggg tgaccaggcg ggccagcacg gtcgccgcgg tctccacttc
    14341 ggtcagcacc tgcgcgggca gctgcacatc ggcgtccagc cgcagatcgc acgcggtccg
    14401 caggccggct gcccgagcgc gtgctgcggg cggtaaaaca tcggtggggt cggcgacggt
    14461 ggcgggcgcg cgcagcgagg agcgcaacaa ccgcacccgc agcagttcac cgagtagccg
    14521 gtcgcgcgcg gtgccgctca cggcggggaa ctccgcggcc agcttgtcgg acaactgacg
    14581 gtacccgatc ggtgatcggg ccaggtcgag tacgagacgc agtgccgggc tgagggcgag
    14641 gcggaactcg gcgtcgccct cggacggtac gtagatgtgc tggtcgcgct gttggatcag
    14701 ggtgttgacg cagacctcgg tgtcggccat gcgtgcagcg tcgctctccc aggtgctgag
    14761 catctcctcg agactgaccg actcggggcg cgccacagcc tggtgctcgt cgccgatgcg
    14821 gacggatgcg gcctgggcga agtcgagcgg ggcgacgccg gcgaacaggc cgtaaggggt
    14881 ggagcggcgt gcgtagcgga ttgcgtagcg ggcggtggac agtgccgccc ggcgcatccg
    14941 gcgcaccttc ggtgtgcggc cgtcgatgat ggcctgcacc tgctcggaga ggcgagggct
    15001 cgcctgcgac acggtccggc ggaaggcggt gtcggaccag accgtgctca gccacgcgcg
    15061 ccactcttcc gcaggcgccg tgcgcgtcgg ccagggcggc atgacgggtt cggtcatgtg
    15121 taccgtggcg cgcagcatgg cctgccccac agcctcgtac atgctgggcc ggtgccgtgt
    15181 catcaacgct ctcctcaact tctacgttgg cgggcgggac gggccggaca gggagaaccc
    15241 cgtccggccc gcattgccgg ggactcccgg cttacgaggt ggtgcaggcg ctggggcagg
    15301 agctgccgca ggtgtcgccc gtgctgcaca tcaggaccgt ctcggtcgcc ggcgtgccct
    15361 cgatgaaggt gatgtcgagt ccgaacgggt cggcctcggt ggtggttgcc aggtccgact
    15421 gcacgggggc ggtcggcctc tccgtctgca cggcggtcat gcttgcctcc tagtggcgat
    15481 gggtggtgcg ggatcccggg acccggtcgg ggcccggagc ttggtgccag acggtggcgg
    15541 gcgaagacac cgcctgggcc aggacgtttg ggagtcggtg tttggtgtcg tcaggctgct
    15601 gcgggccgtg cctgcgggtg gttcttcgcg gccttgtcca gcacccgggt gaattgctcg
    15661 gcgcgctcgt cgccttcggc ttcctgcgcg cggaggtcgc cgaaccggcg ccagtatcgt
    15721 cggcagacgt cgctttccat gagctgcgcg gcgtaccacg gcaggtgccc ggaacgaacg
    15781 aagccgaggc ggtcgcgcag gctgagcatg cagatgagct ggttggcctt caacagctgc
    15841 atgtactcct cgacgtccat gccctcgggc gtccagagct tggtgagatc gggggtggtg
    15901 gacatctggg ccagccagtc gagctggttc cgggcgagga ccgcctcgtt gcgttcggtc
    15961 tggtggcgtg cgtcctgctt gagccgggcg gctccgacca cggcggtggt gaaggcgacg
    16021 gcggtgcctg cagcgaggac ggccgtggtg agcttcatag ggaacggtcc tttctgaatg
    16081 tgaagttgtg acgagcgtcc ggctggtgag gttttcgggg ttccgcttct tcatgcggct
    16141 cttgcaagcg cgacggccgg ggcttcttcg gcatgacgat ccgaggtgta ccggcgacgg
    16201 accgattcca gggcgacagc gatgggcggc aacccgacgc cggcccttcg ctcgtccact
    16261 gattcaggcg cgcgcagcgg gcacagttcg atgccgtcgg cttgaaggag gagttgggtg
    16321 ccgtactcct gctggtgcct gttgttgatc aaagcgcggt cgtgcaggtg cgcccagtgc
    16381 tggatgagtg catcgccaga cttgaccgca cgctccaaga ggatggccgc gccggtgaag
    16441 tcgcccgcgc cgcgcgggtg gacgtacagg gtggtggcgg tgacccgcgc ggagggcgag
    16501 ccgtggcggc cgaaggggcg gtgcggacgg cggtgggcgt gggcgggtgc ggcggacagg
    16561 gccagggcgg agccggccgc ggcgccggcc agcaggacgt tcctccggga caggtgcgaa
    16621 ggcatgcggg tgctccttgg ggggacttgg ggggtgagcc ggtgcggtcc gcagtggggg
    16681 cggaccgcac cggcggcctc ggacggcgtg cgggtcagcg gaggcggccc gcgcccgcgc
    16741 cgaggccgac cagggcgggc acggcccagg cggggtgcac ggccttgcgc agggcgggcg
    16801 tccagccggc gccggagcgc agggtctcct cggggatctc cgcgttgtgc acggcgatca
    16861 ggtcgaccgg ccggccgttg accaggttgt gccgggcggt gaggggcgag tcgttccagc
    16921 gcttgaggac cttcgcgggg ctgatccccc ggggcagggt gaacgcgttg tgctcggcga
    16981 cgagctggga ctccttgccc acgccgaagc tgtagccgta cccggagccg gccacgaagt
    17041 ggttgttgta gacgtctacc tgcccgaacc ggacgcgggg ggtgcgctcg gtgaggtcct
    17101 cgaacaggtt gtggtggaag gtcgccttca gtctgccccg gtcgcccacg gcggtggact
    17161 cgctgtcgct gttgccgatg aggatcgtct tgtcgtgctc ggtgaagacg ttccaggagg
    17221 cggtgacgtg gttggcgccc ttgacgatgt ccagctcgcc gtcgtgctgc tggtagagca
    17281 tgccgaagtg ggtgggtgcg gcgctgtcgg gatgcgcgcc gtcggtgaac gtgttgtggt
    17341 ccagccacac atgggtggcc ccgtgcacga cgacggtgtc gtactcgctg ttccagttgc
    17401 cgcggtcgcc gtcggtgggg tcccactgcg ggaagcagtc gacggggctc tccagggtga
    17461 ggttgcggac gatgacgttg tcgacgtcct tgatctggag gctggcgccc ttgatcgcgg
    17521 cgtcgcgtcc cacaccgatg atcgtggtgt cggaggggac gttcaccttg atgaccgcgt
    17581 cctggtgggc ggcggaggcg cggcgcagcc cttcggggct gtcgtcgggc tcgtcggtga
    17641 ggtcacgctc caggccccag gtcccggggg cgtacgtctc caggtaggcg tcgaagtcgt
    17701 agccggggac ggcgagcgcg tcgcagccgt cggcgacggc gtcgatggtg cccttcacct
    17761 tgatgatcct cggggcgtcc ccgccctccg cgagggccgc ggtgaactgg gcccagtcgg
    17821 tcacggtacg gacgtgcgcg gcctcggcgg cggcgcctcc ggtggtgccc gagccgtagg
    17881 acgcccagcc gtcgcccgcg gggagggtct ggcgggcggg gtcgcgatgc gcgtgcgcgg
    17941 gggtgtgggc ctgggcggcg gtaccggtca gggccagcac gaggacggtg cagccggcca
    18001 gcacgccggc tcctctggca tgcccatgcc atacgtgaac gttcatggtg cggctctcct
    18061 gttcgtggtc cagggggtta cgcggcggcc cccggccagg tgatccacga cgacgggatc
    18121 tcctcggccg gccgccgtac gtcgtgcggc gcgagcaccc ggatgcgcgg cagctcccgg
    18181 gcgaccagcc gtgccacggc gatcgcgccc gtcggtgaga aatgcgtggt gtcctgcttg
    18241 gtgtcggtcc agttgaagta cgcctgcgtc gcctcgggcc ccctcagggg cgcggggaac
    18301 tgcgcacccc tgagggggac ggtccgcagc ggaagaacaa cggaccgccc ccgaacccgg
    18361 aatcacccca tctgctcgtc ccactcggcc tgagcctcgt tcagctgctc ggcgagcccg
    18421 tccaggaagg ccttcgcgct catgtccccc agcagcacct tctggaagtt cggctcgttg
    18481 tccgccttcg agacggtgtt ccagtccggc aggtagtacg gcagctgcac gatggtcgtg
    18541 gacccgtcgc tcagcgcgtc ggccgccagc ttcgtcggct ccgccttcgc gatccacgcg
    18601 tccttcgccg cgtccgcgtg cgccggcacc tgtcccgccg actcgttgaa cttcgagttg
    18661 gactccgccg acgcggcgaa ctcgatgaac ttccaggccg cgtccttgtt cttggagctc
    18721 ttgaacaggc cgatgccgtc gaccgggttg gagacctgca cccgcttgcc gccggggccg
    18781 accggctgcg ggatgccccg gaacttctcc acgcccagcg ccttcacgtg gtcctggtag
    18841 gaacccaggt tgtggttgag catcccgatc tcgcccgagt cccactgcgc gaccatcttg
    18901 gtgaagtcgt tgttgaggtc ggcggcgggc gtgaccttct tgaacagggc cgcgtacttc
    18961 tccagggcct gcacgttctt cgggtcgttg accgtggtct tcttgccggt ggagtcccag
    19021 aacgaggtga tgccggactg cccgtacatc gcgtcgaggg cctgggctat ggagccggcg
    19081 ccgccgcgga tggtgtagcc gaagcggttg ctgcccttgt cggtgagctt ctccgcggcc
    19141 tcgaagaagc ggtcccaggt ggccggctcc tccagtcccg ccttctcgaa catgtcggtg
    19201 cggtagtaca ggacgccgtt gttggcggag gtcggcacgg agtacagctg gtcgtccccg
    19261 ccgccggccg cgcgcagcga ctcgatcatg tccttgttga gcttgccgtt gagcgacgag
    19321 ccctccagcc gctcgtccag cggctcgagc gcgccctggg cggcgaagcc cgcgagcatc
    19381 gaggcgctga tgcctcccac gtccggcatg ccgccgccct ggatggcggt gtccaccttg
    19441 gactggtact cggtggaggc gatgccgacg tactggacct cgatgtccgg gttggccttc
    19501 tcgaagtcgg cgatgatctc cttccagatg tcggtgcgga caccgccgtt gttgtcccag
    19561 aagacgatct tccccttgcc gtcgccctcg gcgcccgcgc cgccgctgcc gtcgtccccg
    19621 caggcggtgg cggtcagcgc gaggaccgct cccagcgcga cggccgccgc cgacctgccg
    19681 cgacgccctc tgcccgtgct tcttccgaga atgctgatct tcatcggtcg gctctcttct
    19741 cctggatgcg gatcctgaac tgcgtgaacg tggcggtacc ggcgtgtccc tgaccggtgg
    19801 gcgccagggc gaccaggccg agcagagcac cgacccagcg ccagggagtc gcggcgaaga
    19861 cctgaccgga ggggcggaag ccctccccgg cgccgtctcc ggcgtcgtcc cccgtgtcgt
    19921 acgagaagcg gcagcgcgcg ccggcgccga tgtcgacgcg cagccgggcc cggccgcccg
    19981 gggcggggcg cgggggtgcg gcgtcccgtt ccctccccca ctgccccgaa ggcgtgggag
    20041 gcgcccccat ggcggacgtc tcggcgaacc ggtgcacgag cccgacggcg ccgtccgggc
    20101 cgcgctcgag cccgatccag ctgtaggcgt caccgaggac cgcgagtccg gcgcgcgccc
    20161 cgggttcgcc gtcgtcgagc cgcaggtcca cctcgacggt gcacggggcg ccgggcagcc
    20221 gctgggtgag gacgttgggc agggcgcgca ggtcgtgcgc gtcgggggtg cggacgcagg
    20281 tgaggcgcag cccgtcggcg aagtggtggg tggcccagcc gtcccggggg ttggcggtcc
    20341 actgccactg gcggccgggg cgtccgccgg ggaagtcgtc gtcggtggcg ggcgcggcgg
    20401 acggctgcgc cggcaggtcc ggacggcggt gctcggcgac gggcgcgccg tggtccccga
    20461 tcaccggcca gcctccccca ccgtcccacc gcatcggctg gaggtggacg acccggccgt
    20521 aggcgccgcg ctgctggaag tgcaggaacc agtcctcgcc ggacggggtg cgtacccagc
    20581 cgccctggtg cgggccgttg acgtcggtgt ccttctgctc caggaccacc ttctcctcgt
    20641 acgggccgaa gaaggcgcgg gagcggaagg cgccctgcca gccggtctcc actcccccgg
    20701 cgggggcgag gatccagaac cagccgtcgt gccggtagag cttgggccct tccagggtga
    20761 accagccggg gaggcggtcg ccgtcgacga tcaccttgcc ctcgtcgagg agttcggtgc
    20821 cgtgcgggtg catccggtgg ccggtgaggc ggttcttgac gccggagcgg gacctggccc
    20881 aggcgtgcac gaggtacgcc tcgccggtct cgtcgtccca cagcgggcag gggtcgatca
    20941 gccccttgcc ggccttgacc aggtgcgggc gggtccaggg gccccggatc tcgggggcgt
    21001 tgacctggaa gatcccctgg tcggggtcgc cccagaagat ccagaagcgg ccgtcgtggt
    21061 ggcgcaggga cggcgcccac accccgcagt cgtgccgggg caccgcgaac tcgccctcgg
    21121 gttcgaggcg gtgcagggcg tggccgacca gggtccagtt gaccaggtcg cgggagtgca
    21181 gcaggggcag tccggggacg cggccgaagc tggacgcggt gaggtagaag tcgtcgccga
    21241 cgcggatcac gtcggggtcg gaccagtcgg cgtcgaggac ggggttgcgg tagacggggt
    21301 cgtcgggggc ggcgctcatg cggtcaccgc cttcgtgacc agggcgccgg catcctcacg
    21361 gccgagccgg ccgtcggcga cgacggtgac gacccggcgc tccaccgtct ccccgggcgg
    21421 gacgggcagc cgcgcgtcgt gcgcgaggga ggagccgacg cccgggtact cctcggtgcg
    21481 cacgaaccag gggtctcggc gggtcgcctc cgtggccgcg gcgaggacga gggtccacgt
    21541 ggagccggcc agggcgaccc agtcggcggt ccgtccgtgc acggcgtcgg tgccgtcggc
    21601 cgccgcggtg aacacctcgg gctccgtgtc ctccttgcgg gcccgccaga agaagccccc
    21661 gtaggcggcg ccggggcggc cgttggtggc ggggctgccg acggacagcg ggcgaccgct
    21721 gacgttggtg agggcgaagg tcaggtccag ggcccaggcg ccgtcggtga gggcggtcgc
    21781 ggtgaccgtg cgccgttcgc gcagcagttc gccgggcgcg gccgtccagc gcagttcctc
    21841 ggtgaagccg tcggcctcgc gccggtggta cgcggtgtgc cgctgggcgc cgtggttgtc
    21901 cagctcggtg ggaccgcggt cgcggacgta ggtgcgtccg ccccagaagt tgaacccctc
    21961 gacgtcggga acggcgacac cgacgccgag gtggtgtgcg tggtcggcgg ggctcagctc
    22021 ggtgaccgcc gtgccggcca gggtggtgac ggggtgcagg tagggccgcg gggagagccg
    22081 ggccggcagt tccggccggg tgacgtaccg ggcgacgggc cggccggcga cgcgcagcac
    22141 cacggagtcg ttgccggtca tcgggtgctc acctcttccg gcagatggtg gtgggcgggc
    22201 cgggcccagg gggcgcccag ctcggagtag aggcacaggc ggtccgccgc ggccgcgacc
    22261 agggcgtcga tgccgggcac cacccggcgg tcctcgccgg ggacacggcg ccaggcgtcg
    22321 tcgggcagcg gctccgggtc gggggcggtg cggatcgcct cgacgacctg catgaaggcg
    22381 ccggtgtcgt cgggggtgac cagcagctcg gtgccgtcac ggaggtgggc gacgaggttc
    22441 tccagcaggt cggtgcggtc gaagcgcagt tcctcgggac cgtggtccgc gcgctggagc
    22501 aggacgcggt cctgcttgta ccagaaggtg atgcggccgc tggtgccgtg caccaccacg
    22561 tacggctcgt cggcccgctc cgcgcacagg gtggcggcga cggtgaccga gccgccctgg
    22621 acggtggtga cgcggacgca ggaggtgtcg tcggactcga tgtcgttggc gcgcagcagc
    22681 tcggtctcga tgcctgcgac gtcctcggcg cgggtgctcc cggcgagcgc gagggcggtg
    22741 gcgacggcgt gcgcgagggg attggtgagc gccccgtcga ccacgtcggc gccgtcgagg
    22801 cgccggcggc ccgcccaggg cgcgcggcgg aagtacgcct cggggcgcac ccaggcgccg
    22861 gccccgccga tgcccgtgac ccggccgacg gcgccttcgg cgatcaggtc gcggatcgcg
    22921 ggcacggcgt gcgagccgag cgactggaag ccgatctggc aggccacccc ggccgcggcg
    22981 accccgtccg ccatccgccg gaacgcggcg tacgagggcg ccgggggctt ctcgaggagc
    23041 aggtgcacgc cccgttcggc ggcggtgagc gcgagggcgg tgtgggtggg gatgggggtg
    23101 cagatcaccg cggcacgggc gccggtggag tcgaggagcg cgccgaggtc ggcggactgc
    23161 tcggggagtt cgccgccgaa ctcgtcctcg gtgagcgggg tgagctcgca gatgccggcg
    23221 agccgtacca ggcccttcgc tgcgaggcgg cggatgttgt ccacgtgccg gcggccgtga
    23281 ccgcgggcgc cggccaggac aacgggcagc ggggtgcggg tcatcgtccg gggggcgctc
    23341 atcccttcac cgcccccgcg ctgaagccgg tgatcagcca cttctggatg aaggcgaaca
    23401 cgatcacgac ggggacggcc gcgatgatgc cgccggcggc gagcgcgccg aggtcgacgc
    23461 tgtccgcgct catcagcgtg ttgagaccga cggggacggt ctgcttctcc tggttgttga
    23521 ggaacatcag ggcgaacagg aagtggttcc aggagtgcac gaaggcgaag gagccgacgg
    23581 cgatcaggcc gggccgcagc agcggcagga cgaccacccg gaacgcccgg aaccggtcgc
    23641 agccgtcgac ccaggcggcc tcctccagcg agtagggcac gttcttgatg aagttgctga
    23701 gcaggatcat cgacagcggc agctggaaca ccgtctcggc gatgatgacg ctgcccaggg
    23761 agttgatcat ccgcagctcg gcgaagatct cgaacagcgg gaccagcagc agcgcgccgg
    23821 gcacgaactg cgagcagagc agcgcgagca tgaagccgcg cttgacccgg aagtcgaacc
    23881 gggcgagcgc gtagccgccg gccagggcca ccagggtggt catgaacagg gtggcgacgc
    23941 cgacgaggac gctgttctgg aagaaggtgc cgaagccgcg gtccgtccac accttctcga
    24001 agtgggcggt ggtcatcggc cagggcacga gcgaggtgga gccggccgga cgcagcgcga
    24061 acagcaggat ccagtagaag gggatgaggg tgaagacgag gtagatgccg agtggcaggt
    24121 agatctgcca gcggggcgcc tcgtcccagg accggcgccg cgtcgtgggc cggggcggct
    24181 cggggacggc ccgccggcat gagcccggcc gcgctctaca tccactacaa gaccaaggaa
    24241 gagctgctcc accgcatcag ccgcatcgga cacgagaagg cgctggacat cctgcgcacc
    24301 gcgtcccgcg gcgagggcac cgcgaccgag cggctcgccg acgcggtcag ctcgttcgtc
    24361 cgctggcacg cgcgaggccg tacgaccgcc agggtcgtgc agtacgagct cgactcgctg
    24421 ggcccggacg cccgcgcgga gatcgtcggc ctgcgccgcc aggtcgacgc cgaggtgcgg
    24481 gggatcgtcg aggacggcgt ccgctcgggc gagttcgacg tccccgacgt gccgggcacc
    24541 acgctcgccg tgctgtccct gtgcatcgac gtggcccgct ggttcaacgt cgacgggccc
    24601 cgcaccccgg aggaggtcgg cgcactctac gccgacctcg tgctccgcat ggtgggggcc
    24661 gagaacgccg gaaccgccta gaggtagtac cgggccaccg actccgccac gcacaccggc
    24721 ttgtcgccgc cctcgcgctc cacggtgaag gcggtggcga cctggacgcc gcccgagacc
    24781 tcgtccacgg cgctgatcct cgccgtggcg cgcaggcgcg agcccaccgg tacgggggcc
    24841 gggaagcgca ccttgttcgt gccgtagttg acgcccatcc tcacgccctc gacggacagc
    24901 agttgcgggc cgaacagcgg cagcagcgac agcgtcagat agccgtgcgc gatggtcgtg
    24961 ccgaacgggc ccgccgcggc cttctccggg tccacgtgga tccactggtg gtcaccggtg
    25021 gcctcggcga acaggtcgat ccgcttctgg tcgatctcca gccagtcggt gtaccccagc
    25081 tgctcgccca ccgccgcctt caggtcgtcg acggacgtga agatcctcgg ctctgccatg
    25141 tcccggcctc tcgcgtcacg tagtcgcagg cgcatccgcg tgc
//
