LOCUS       NZ_RAII01000001        22157 bp    DNA     linear   CON 15-MAY-2024
DEFINITION  Streptomyces sp. E1N211 s-211_S3_L001_R1_001, whole genome shotgun
            sequence.
ACCESSION   NZ_RAII01000001
VERSION     NZ_RAII01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. E1N211
  ORGANISM  Streptomyces sp. E1N211
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7318313)
  AUTHORS   Vicente,C.M., Thibessard,A., Lorenzi,J.N., Benhadj,M., Hotel,L.,
            Gacemi-Kirane,D., Lespinet,O., Leblond,P. and Aigle,B.
  TITLE     Comparative Genomics among Closely Related Streptomyces Strains
            Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
  JOURNAL   Antibiotics (Basel) 7 (4), 86 (2018)
   PUBMED   30279346
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7318313)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2018) Dynamique des Genomes et Adaptation
            Microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Genomics Workbench v. 6.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003671735.1-RS_2024_05_15
            Annotation Date                   :: 05/15/2024 02:33:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,941
            CDSs (total)                      :: 6,866
            Genes (coding)                    :: 6,131
            CDSs (with protein)               :: 6,131
            Genes (RNA)                       :: 75
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 736
            CDSs (without protein)            :: 735
            Pseudo Genes (ambiguous residues) :: 0 of 736
            Pseudo Genes (frameshifted)       :: 138 of 736
            Pseudo Genes (incomplete)         :: 673 of 736
            Pseudo Genes (internal stop)      :: 17 of 736
            Pseudo Genes (multiple problems)  :: 87 of 736
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:49:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 324307
            Orig. end                         :: 346464
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RAII01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22157
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22157
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22157
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12157](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12157
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            767..1000
                     /locus_tag="EBH12_RS01405"
     CDS             767..1000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521329.1"
                     /locus_tag="EBH12_RS01405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_114875566.1"
                     /transl_table=11
                     /translation="MTSTTGTTGTTGTACPYCGWPDHAEPFQVVSRHATAAGSTVWTRC
                     GCGSLQVRAVDARGMRVMSRSRPADVPAPGGR"
     gene            1107..2297
                     /locus_tag="EBH12_RS01410"
     CDS             1107..2297
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823503.1"
                     /locus_tag="EBH12_RS01410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_114875565.1"
                     /transl_table=11
                     /translation="MDVRRLPLSGVTVVTVEQAVAAPYATRQLADLGARVIKVERPGEG
                     DFARRYDTTVHGTSSYFVWINRSKESLTLDLKEPRGLEILHELLADADVFVQNLAPGAA
                     GRLGLGADDLAGRHPRLIPCAISGWGTTGPWADRKAYDLLVQCQTGLVSLTGTPGETAR
                     TGISVADIAAGMYAYSGVLTALYTRATTGEVHPVEVSLFEALAEWMGQPAYYTRYGGTQ
                     PPRLGTQHATIAPYGTFRAADGREVLFSIQNEREWAALCREFLGRPELTDDPRFATSSD
                     RVAHRDDLNAVVAERCARDDAEELLKDLEAIGIACAGVNDVAAFLDHPVLAARGRWREI
                     RVPGGTAEALLPPADLAGLPARMDPVPAVGEHTEAILRALGRTPGDIEALRADGVI"
     gene            complement(2537..3184)
                     /locus_tag="EBH12_RS01415"
     CDS             complement(2537..3184)
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979745.1"
                     /locus_tag="EBH12_RS01415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="WP_048454976.1"
                     /transl_table=11
                     /translation="MRFRDRRQAGRELAGRLRERQDAGDLADPLVLALPRGGVAVAAEV
                     AEALGAPLDVLVVRKIGAPRHEEYGVGAMADDGVPVFDEDALRGLGLTRDDLAPVVERE
                     RTELARRERLYRPGRPAPDPRGRTVVVVDDGLATGSTARAALRALRARDPARLVLAVPV
                     ASPEGAAALRPETDDLIALHEPAAFMAVGQWYDEFDQLTDEEVLEALRVRRR"
     gene            3299..3754
                     /locus_tag="EBH12_RS01420"
     CDS             3299..3754
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131693.1"
                     /locus_tag="EBH12_RS01420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="archease"
                     /protein_id="WP_048454977.1"
                     /transl_table=11
                     /translation="MVGDTGEPGQAPRRDRSGHRSVAQEDDVRIEAWAASREHCLAEAV
                     VAMVECFADVSGVRPTGVDRIRLAEGSDDDLLAALLDEILYRLEAYGEVPVDVEADEAE
                     GGLDVRLAVAGLADVRVTGEVPTDVGWDDLRLSPGPYGWSCAVTVDG"
     gene            complement(3771..4196)
                     /locus_tag="EBH12_RS01425"
     CDS             complement(3771..4196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027424.1"
                     /locus_tag="EBH12_RS01425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /protein_id="WP_114875563.1"
                     /transl_table=11
                     /translation="MTTRVRDVMSAHTTSVEPMTSLTRAARLMREQNVGDVLVAYDCDL
                     FGVLTDRDIVLRGVAEGHDPEATNVGSICTRPPLVTLEPDDTTDHAVELMREHAVRRLP
                     VVEHGGCPVGVVSLGDLAAEEDPHSALADISRARPTH"
     gene            4373..5623
                     /locus_tag="EBH12_RS01430"
     CDS             4373..5623
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521334.1"
                     /locus_tag="EBH12_RS01430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_114875562.1"
                     /transl_table=11
                     /translation="MDGRRSAAWRFGWLWTAYGVSAFGTRFAFDAFALVALLVLHAGPA
                     QVSLLAAVGPAVGAVLSVPLGPWVEYRRKRPVMIATDLVRCAVLLSVPLAYALDALTVA
                     QLLVVSVTVAAADITFQAAVGAYVKDVVPRQGLLRANGRLESTTWTATMLGPPLGGAAI
                     GLFGPVTTVVADAVSYLLSAGALGAAGGGERRPERPDPRPRLRAGDLLDGWRYILRSPD
                     LRPLFLNTVLVNGLIMASSPLLVVLMVGPLGFAPWQYGLAFAVPCLGGLAGARLSRRLV
                     ARFGERRVLRVAGTLRACWSVGLACVVPGVAGLALVIVIEFGLITSMGVFNPVFSTRRL
                     ERTPADRVVRTLSAWSATSKASIAVLTALWGLLASFTGPRTAIALAGALLLATPLLLPR
                     RLDEARRDQDSEAEAKA"
     gene            complement(5636..5983)
                     /locus_tag="EBH12_RS01435"
     CDS             complement(5636..5983)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545939.1"
                     /locus_tag="EBH12_RS01435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_048454980.1"
                     /transl_table=11
                     /translation="MTVRRVVPNLHSENPERHGEFYGLLGLEEVMDHGWIMTLASPSNP
                     TAQVSVMTGDRTAPAHPDISVEVDDVDAVYEAVRESGAEIVHPLRDEEWGVRRFFVRDP
                     DGRVVNVLSHR"
     gene            complement(6142..6264)
                     /locus_tag="EBH12_RS37235"
     CDS             complement(6142..6264)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EBH12_RS37235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_274595019.1"
                     /transl_table=11
                     /translation="MRSAEEVRRDTEAYGTTVPAGLWADPRGEGLLDARAPLPA"
     misc_feature    6339..6353
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.74"
                     /tool="antismash"
     gene            complement(6370..7107)
                     /locus_tag="EBH12_RS01445"
     CDS             complement(6370..7107)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-179). E-value: 1.5e-18. Score:
                     59.3. Matches aSDomain:
                     nrpspksdomains_EBH12_RS01445_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669731.1"
                     /locus_tag="EBH12_RS01445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_114875561.1"
                     /sec_met_domain="adh_short (E-value: 5.7e-35, bitscore:
                     119.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTVQDKVIAITGASSGIGEATARLLAGRGARLVLGARREDRLNA
                     VVDGITAHGGTAAGVVVDVTRREDLRRLTDTALERYGRLDVLVSNAGTMAVSPFDELRQ
                     DDWDAMVATHVTGLLNGIGAALPVFRRQGTGHFVNVSSTAARVIKSPQAVYAATKAAVH
                     VISEGLRQESGPGLRVTVVSPGFTHTEGVGKGASPEAAAAMTKTRDEIAMPPSAVASAI
                     GYAIEQPAGVDVGEIVVRPTAQA"
     aSDomain        complement(6571..7086)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EBH12_RS01445_PKS_KR.1"
                     /evalue="1.50E-18"
                     /label="EBH12_RS01445_PKS_KR.1"
                     /locus_tag="EBH12_RS01445"
                     /protein_end="179"
                     /protein_start="7"
                     /score="59.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIAITGASSGIGEATARLLAGRGARLVLGARREDRLNAVVDGITA
                     HGGTAAGVVVDVTRREDLRRLTDTALERYGRLDVLVSNAGTMAVSPFDELRQDDWDAMV
                     ATHVTGLLNGIGAALPVFRRQGTGHFVNVSSTAARVIKSPQAVYAATKAAVHVISEGLR
                     QESGPGLRV"
     CDS_motif       complement(6991..7077)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EBH12_RS01445_0001"
                     /evalue="1.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="EBH12_RS01445"
                     /protein_end="39"
                     /protein_start="10"
                     /score="14.4"
                     /tool="antismash"
                     /translation="ITGASSGIGEATARLLAGRGARLVLGARR"
     gene            7244..7819
                     /locus_tag="EBH12_RS01450"
     CDS             7244..7819
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982033.1"
                     /locus_tag="EBH12_RS01450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_114875560.1"
                     /transl_table=11
                     /translation="MADQAPRPLRADAQRNREKILTSAAHVFSTEGLTTHMDRIAKEAG
                     VGSATLYRNFPTREALVEAVYRNEVAQLCGSVPSLLERHPPEEALRAWTRLFLDYVTTK
                     HGMIDALRAIAATGANPYGNSRQLIHTAVGTLMDACAAAGVIRTDVPASDIGAALEGIA
                     LTSAGPGRREQAERLLDLILDGLTVRRG"
     gene            complement(7833..8423)
                     /locus_tag="EBH12_RS01455"
     CDS             complement(7833..8423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979764.1"
                     /locus_tag="EBH12_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside adenylyltransferase
                     domain-containing protein"
                     /protein_id="WP_121740222.1"
                     /transl_table=11
                     /translation="MGAPRGGGGEALPCPAAGLELVVYPADFAARPSGEAGYLLDLNTG
                     PSLPERVSDDPADASDFWYVIDRSVAHQAGLPLYGAPAREVIAAPDRTTVLAALRASVR
                     EHADGDGHLADNRVLNGCRATVHCRTGHWFAKRRAGEIVAASEPAFEPLVAEALRSFER
                     PRAEAAVLPAGDVRALLAWVAARVEEAAEGAGV"
     gene            <8567..8686
                     /locus_tag="EBH12_RS01460"
                     /pseudo=""
     CDS             <8567..8686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981896.1"
                     /locus_tag="EBH12_RS01460"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="QPPRTAEMWQLLIRGLVPVTRRARYLSLAARLEREPAPL"
     gene            8727..9905
                     /locus_tag="EBH12_RS01465"
     CDS             8727..9905
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523405.1"
                     /locus_tag="EBH12_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_114875099.1"
                     /transl_table=11
                     /translation="MPDTPAGPVIVADEPGTFPYGVLAERHPAILRQVAADTPYGPEQR
                     RALDALLVNCTEGAVTPLPAGAHDRDRWAAWGMDDHAGRSWHDVPWLWSESWFYRQLLQ
                     AVRYFEPGPWQGVDPFRPAKLAELDAPATDEELAALDALDDLPEDERARALLHGSLWGN
                     RADLGFRMSAEGAEETAAVPALVADDGERLWSLLDGSPDGTLCLVADNAGRELVPDLLL
                     IAHLLAQGRVTRAVLHVKPHPYYVSDATTADVLDAVRRLTAAKGAAGAYGHALRAALTD
                     GRLELRAHPFSCAPLPYADMPDDLRADFAEATLTVLKGDLNYRRLVGDRYWPPTTPFAG
                     VTAYFPGAVAALRTLKSDVITGLAPETEAALDAEESGRWRTSGTHALIQVRT"
     gene            10001..12157
                     /gene="cyc2"
                     /locus_tag="EBH12_RS01470"
     CDS             10001..12157
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523404.1"
                     /locus_tag="EBH12_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_114875100.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-79, bitscore: 266.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPHPARLNPHVDQARAHSTAWAREMGMLEGSGVW
                     EQADLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLEKYKRTQDRVGGKAH
                     LDRLPLFMPLEPGTPVPEPENPVEAGLADLWARTVPAMSTDWRRRFAVATEHLLNESLW
                     ELSNINGGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPAAVAGTRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQKAADLVNDVLTSRLHQFEHTAF
                     TEVPAVALENGLTSPETAAVAAYAKGLQDWQSGGHEWHMRSSRYMNENARPGASWQSVT
                     GPGTSAADVGALLARAASERLRPYRHVPYRKVGPSVVPEIRMPFPLSLSPALEGSRRHL
                     LEWSHRMGILGEGVWDEDKLASCDLPLCAAGLDPDATQEQLDLASGWLAFGTYGDDYYP
                     LVHGHRRDLAAARLTTARLSACMPLDGEEVPLPANAMERSLIDLWARTTAGMTPEQRRP
                     LRTAVDTMTESWVWELSNQIQNRVPDPVDYLEMRRATFGSDLTLGLCRAGHGPAVPPEV
                     YRTGPVRSLENAAIDFACLLNDVFSYQKEIEFEGEMHNAVLVVQNFFGIDYATALPVVA
                     DLMNQRMRQFEHVVEHGLPVVYDDFQLSEEARAVMRGYVTDLQNWMAGILNWHRSVDRY
                     KDEYLSGRVHGFLPHRSPAPPVLV"
     gene            12200..12646
                     /locus_tag="EBH12_RS01475"
     CDS             12200..12646
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535578.1"
                     /locus_tag="EBH12_RS01475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_121740223.1"
                     /transl_table=11
                     /translation="MPGAHAGPRPDPAPAVPEEPPAGRPAGRRAAAGLALLLTGAALGV
                     LAAAWAGPAPASGPALSARLGVEVTDAGRPGALVVGVQNPGPGHTAGLREGDLLLAVGA
                     TRVGTAADLAREVFRIPPGTPVRLTVRHPTGGYQQLTAVPGILT"
     gene            13345..14472
                     /locus_tag="EBH12_RS01480"
     CDS             13345..14472
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="EBH12_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_121740224.1"
                     /transl_table=11
                     /translation="MTGTAPVPFTADDYKDRMDRAARQAADAGLAGLLVAPGPDLVWLT
                     GYAPPAVTERLTLLVLAAGREPVLVVPTLEAPDAEKATGAPALALRDWTDGKDPYALTA
                     ALLDDRGRFGVSDNAWALHLLGLQQVLPGTSYVSLTDALPMLRAVKDAAELERLAAAGA
                     AADAAFEEIRNVRFSGRPESEVAADLAALLRRFGHSQVDFTIVASGPNGANPHHEAGDR
                     RIGRGDMVVLDFGGLKDGYGSDTSRTVHVGEPTEEERRVHDLVREAQEAGFRAVRPGAA
                     CQDVDRAARAVIADAGYGEYFVHRTGHGIGVTTHEPPYMIEGEERPLVPGMCFSVEPGV
                     YLPGRFGVRIEDIVTVTEDGGRRLNDTERGMVIVD"
     gene            14538..15488
                     /locus_tag="EBH12_RS01485"
     CDS             14538..15488
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523401.1"
                     /locus_tag="EBH12_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_121740225.1"
                     /sec_met_domain="APH (E-value: 1.9e-20, bitscore: 72.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTVDTVRRLARSLLEDSGHGTAASAAALDVRLAGDGADP
                     TTWLVGTRYVLHLAPDRATGVRWRRELRLREVVRPHVSVALPVGVAQGEWAPGLPCTLE
                     TRLPGGTAEENTVSAVGETDLAGLLTGLHQVPVRQAEALGVPRVPPRSLETLRRAAGEA
                     VELLDKADEFEAARLRQFTQAATVQLAAQAGSVVLVHHALTGGNLVVGVDGRVRGVLGW
                     DTAVVGDPAEDIAGLARAVGAPAAVRAATLAGYGARPCLRGLWLARCDCVIHLAEALVH
                     NATASLPLLRTRLRRAWEPIMLERVTDLRDSDAAP"
     gene            complement(15547..17292)
                     /gene="treZ"
                     /locus_tag="EBH12_RS01490"
     CDS             complement(15547..17292)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034231.1"
                     /locus_tag="EBH12_RS01490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_114875101.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.2e-11, bitscore:
                     41.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQAGRVTLRCDGVTRAMERDPEREGWWRGEAEAHDGSR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHDRFEWSAEWTGRPLPGAVLYEMHVGTY
                     TREGTFDAAAERLGHLADLGVTHVELMPVCPFPGRHGWGYEGVSLWAVHEPYGGPEGLK
                     RFVDRAHGLGLGVVLDVVHNHLGPSGNYLPQFGPYFTDTHHTPWGVAVNLDAPGSDEVR
                     AYLVESALAWLRDHRIDGLRLDAVHALVDTRARHFLEELSQAVDELAADTGRPLFLIAE
                     SDLNDPRVITPRDRGGLGIHAQWNDDFHHALHTALTGESQGYYADFARAPLAAVAKTLT
                     GGFFHDGTYSSFRGRHHGRPLDRTRVAAHRLLGYSQTHDQVGNRAQGDRLSALVSPGLL
                     ACAAALTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELAKAVSQGRRREFAAHGWAEQ
                     DVPDPQDPATRDRSCLDWSEREREPHARMLAWYGQLLAVRREQPDLTDPDLADTKVAYD
                     EDRRWLAFRRGDVRVAVNLGAEPADIPLGSREARVLAAWEPVDVPGADGLLRLPGESAV
                     VLLQE"
     misc_feature    complement(17466..17484)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            17513..18064
                     /locus_tag="EBH12_RS01495"
     CDS             17513..18064
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="EBH12_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_048455536.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDAERDKALSVLRDGVAKGRLSHDTFIRRME
                     LALVARRADELTALTADLPRESRLSRVVFGSVEAVSGFTVRLRRAWRAEKLPKLLLPHP
                     AHGHPLRIGRDPASGLRLTHETVSRVHAELTRQGGLWVLRDLGSTNGTTVNGRRVVGAA
                     VVREGDQVGFGRIVYRLSVN"
     gene            <18129..18588
                     /locus_tag="EBH12_RS01500"
                     /pseudo=""
     CDS             <18129..18588
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523398.1"
                     /locus_tag="EBH12_RS01500"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RPYVAGVPDADRLLAPVEDHLLVCPGLADAWDSDRGTILCVRCRP
                     "
     gene            18585..19010
                     /locus_tag="EBH12_RS01505"
     CDS             18585..19010
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071457.1"
                     /locus_tag="EBH12_RS01505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_048455535.1"
                     /transl_table=11
                     /translation="MTHTSVKTVGAGLSAAALLLLAGATPAAHADTSPEPGNWLMLSVS
                     HGEAPAAGAEGGTLLRCDPPGGGHPHAEEACAQLSAADGRITTLPAENTLCPMIHAPVT
                     AHAEGVWRDRPVTWSETFPNTCALRAHTGALFALDGT"
     gene            complement(19363..20619)
                     /locus_tag="EBH12_RS01510"
     CDS             complement(19363..20619)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700049.1"
                     /locus_tag="EBH12_RS01510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_121740226.1"
                     /transl_table=11
                     /translation="MGPLRESRYPTVAELVFSARALAIQWPGLCVLRQVGVSRGGRPLH
                     LLSVGRARHAVLVVAGAHANEPAGNGTLLALARRTLLERELRDGVSWHFLLCADPDGAS
                     LHVTPAPRSLYDYHLGFFRPAGHEQPEWAPSVLPADRLPPETRALTGVIDELRPFLQVS
                     LHGTDLGGSWVQLTRDVPGLAEPFAKSAAELHIPVETGASDAAGWPASGPGVHVMPAPE
                     AAPAYPSLSDDARHSTWHHAHRYGGLTAVVEVPMWASDLVDDPAPHPAPDTAMHALAER
                     LLRDADAVRHVLEDVRPGPPPTEADGPLLRAAAWVLELVPGLAADLVRTPPADGTRAYV
                     GSVDAFARRVPLRAAAMLRRALRDAGAQAAARLDHLVAHWSDAFATRFRARWVPVRHQV
                     EHQSRTVVAAARQARAGLM"
ORIGIN
        1 atcacctgga gccggcacgg actctccggc accggggcga tccacggctc gtgcgccgcc
       61 tcggccaggt cgacccgctc ccgcccggcc agcacgtgcg cgtccggcac caccaggtcg
      121 aacgggtcgt ccagcaaggg cttctggtcg aaccgcgtgt cactcatagg cgggttgtgc
      181 ggggtggact ccaccacggc cagatcggcg gcgccctcga agagcaggtc gaaaatggcc
      241 ggaacgaccg cctccgtgat ccggaccgac agccgcggat gccgctcgcc gagccgggcc
      301 gccaacggcg cgagcagcac cgagacggcc accgggaacc cggtcacccg cagcaccccg
      361 gcggggtcgc cgtggtcggc gcgcagatcc agctcggcct ggtcccagcg ggcctggatg
      421 gcgtcggcgt gcgcgagcag gctctcggcg gccggggtga ggcgcacccc gcgcccctgg
      481 ggttccagca ggtcgacgcc gaggtcgcgg gcgagctggc ggatctgctg ggaggcggcg
      541 gagggcgtga agtgcagggc gcgggcggcc gcggtgaccg tgccgtagtg ggcgaccgct
      601 ctcaggacgt ggagccggcg caggtcaatc atgaagctaa cgcttcacgg tcgtgtgcac
      661 aaagtcaacc tggacgtgaa cataaccgtc ggcgcactct tgatgtgccg cgaccgacag
      721 caggcacacg agtcacgtca agcacgtggg aatccaagga gtcgccatga ccagcacgac
      781 cggcaccacg gggacgaccg gcaccgcctg cccctactgc gggtggccgg accacgcgga
      841 gccgttccag gtcgtctcgc ggcacgccac cgcggcgggc agcacggtgt ggacgcgctg
      901 cggctgcggg tcgctccagg tgcgcgcggt ggacgcgcgc ggcatgcgcg tcatgtcccg
      961 cagccgcccc gccgacgtgc cggcgccggg cgggcggtga ggggaggcgt tgacaggcgg
     1021 ttcgccctgg tcgtactaat cgcgtagtga tcgcgtaccg gccgagggag gccggcgacc
     1081 gacgcacccg ggtgcggaca ggaggcgtgg acgtgcggag actccccttg tccggtgtga
     1141 cggtggtgac ggtggagcag gcggtggccg cgccctacgc cacccggcag ctggccgacc
     1201 tcggcgcccg ggtgatcaag gtggagcggc cgggcgaggg cgacttcgcc cggcgctacg
     1261 acaccaccgt gcacggcacg tccagctact tcgtgtggat caaccgctcg aaggagtccc
     1321 tcaccctcga cctgaaagag ccgcgcggcc tggagatcct gcacgaactg ctggcggacg
     1381 ccgacgtgtt cgtgcagaac ctcgccccgg gcgcggccgg ccggctcggg ctgggcgcgg
     1441 acgacctggc cggccgccat ccgcggctca tcccctgcgc gatctccggc tggggcacga
     1501 cagggccgtg ggccgaccgc aaggcgtacg acctgctcgt gcagtgccag acgggcctgg
     1561 tgtcgctcac cggcaccccc ggggagaccg cccgcacggg catctccgtc gccgacatcg
     1621 ccgccgggat gtacgcgtac agcggtgtcc tcaccgccct ctacacgcgc gccaccaccg
     1681 gcgaggtgca ccccgtcgag gtgtccctgt tcgaggcgct cgcggagtgg atggggcagc
     1741 ccgcctacta cacccggtac ggcggcaccc agccgccccg gctgggcacc cagcacgcga
     1801 cgatcgcccc gtacggaacg ttccgggcgg cggacgggcg cgaggtgctg ttctccatcc
     1861 agaacgaacg cgagtgggca gcgctgtgcc gggagttcct cggccggccc gagctgacgg
     1921 acgaccctcg gttcgcgacg agttcggacc gtgtcgcgca ccgggacgac ctgaacgcgg
     1981 tcgtggccga gcggtgcgcc cgtgacgacg cggaggagct gctgaaggac ctggaggcga
     2041 tcggcatcgc ctgcgcgggg gtgaacgacg tcgcggcgtt cctcgaccat ccggtgctgg
     2101 cggcgcgcgg ccggtggcgt gagatcaggg tgccgggcgg cacggcggag gcgctcctcc
     2161 cacccgccga cctcgcggga ctcccggccc gcatggaccc ggtgccggcg gtgggcgagc
     2221 atacggaagc gatcctgcgc gccctgggcc gcacacccgg ggacatcgag gcgctgcggg
     2281 cggacggggt gatctgagcc gggcgcgcac cggcgggtgg atcccccggg actcgaggct
     2341 ctcgcctcgg tcccccacgg ttcggggcct ccgcgcggga cccgccgacc cggcgcacga
     2401 tgcccgcggc acgcgcgcca ccgcgcggag cgatccggcg tctgcacgcc accgggccgc
     2461 gcccgtcacc tcggcgggca cgggcggccg ccccggccgg gcccggagtc cgggcggcgg
     2521 acggcgtcgg ggagggctac cgccggcgta cgcgcagtgc ttccaggacc tcctcgtccg
     2581 tcagctggtc gaactcgtcg taccactggc cgacggccat gaacgcggcc ggttcgtgga
     2641 gggcgatcag gtcgtcggtc tcggggcgga gggccgcggc gccctccggg gaggcgaccg
     2701 ggacggccag gaccagacgg gcggggtcac gggcgcggag ggcgcgcagg gcggcgcggg
     2761 ccgtggagcc ggtggccagg ccgtcgtcga cgacgaccac cgtgcggccg cgcgggtcgg
     2821 gcgcgggcct gcccggccgg tagagccgtt cgcgccgggc cagctccgtg cgttcccgtt
     2881 cgacgacggg agcgaggtcg tcccgcgtca gccccaggcc gcgcagggcg tcctcgtcga
     2941 acacgggcac cccgtcgtcg gccatggcgc cgacgccgta ctcctcgtgg cggggcgcgc
     3001 cgatcttgcg gacgacgagg acgtcgaggg gcgcgccgag cgcctcggcg acctcggcgg
     3061 cgacggcgac gccgccgcgg ggcagcgcca ggacgagggg gtcggccagg tcgccggcgt
     3121 cctgcctctc ccgcagccgg ccggccagtt cgcggccggc ctgccggcga tcacggaacc
     3181 gcatgacggg ccctccctcc gagcggtcac gaccggtcgg cacccgcgta ccccctcgcc
     3241 cggtgcacga agcaccgccg cggggcatgg ggtgcgtgcg cccgggcagt cgtggtgcat
     3301 ggtcggtgac acgggtgagc cgggtcaggc gccgcggcgg gaccgcagcg ggcaccgctc
     3361 ggtggcgcag gaggacgacg tacgcatcga ggcctgggcg gcgagccgcg agcactgcct
     3421 ggccgaggcg gtggtggcga tggtggagtg cttcgccgac gtgtccggcg tgagaccgac
     3481 cggggtggac cgcatccggc tggccgaggg gagcgacgac gacctgctgg ccgcgctgct
     3541 cgacgagatc ctgtaccggc tggaggcgta cggcgaggtg ccggtggacg tggaggccga
     3601 cgaggccgag ggcggtctgg acgtgcggct cgcggtggcg gggctggcgg acgtgcgggt
     3661 caccggggag gtgccgacgg acgtcggctg ggacgacctg cggctgtcgc cgggcccgta
     3721 cggctggtcg tgcgcggtga ccgtggacgg ctgagcttcg acggccccgt tcagtgggtc
     3781 ggccgggcgc ggctgatgtc cgcgagcgcg gagtgcggat cctcctcggc ggcgaggtcg
     3841 ccgaggctga ccacgcccac ggggcagccg ccgtgctcca cgacgggcag ccgccgcacg
     3901 gcgtgttccc gcatcagctc gacggcgtgg tcggtcgtgt cgtccggttc gagcgtcacc
     3961 agcggcgggc gggtgcatat cgagccgacg ttcgtggcct cggggtcgtg cccctcggcg
     4021 acgccccgca gcacgatgtc gcggtcggtg agcacgccga acaggtcgca gtcgtaggcg
     4081 acgaggacgt caccgacgtt ctgctcgcgc atcagccgcg ccgcccgcgt cagcgaggtc
     4141 atcggctcga cggaggtcgt gtgcgcggac atcacgtcgc gtacgcgcgt ggtcatgggc
     4201 gcctcccggt gcgtggtcac ggtcgcgggt gcggtcgcgg gcctcccctg cgggccgcgt
     4261 agcccgccgc gccgggagta aaccggtccg gtttgcccgc ggcggcccgg ctcgcttgga
     4321 tgggccggtc cccggcggcg gccggggctc ggccggtgtg agcggggggc tggtggacgg
     4381 gcggcggtcg gcggcgtggc ggttcgggtg gctgtggacg gcgtacgggg tcagcgcctt
     4441 cggcacgcgg ttcgcgttcg acgcgttcgc gctggtcgcc ctgctggtgc tgcacgccgg
     4501 tccggcccag gtgtcgctgc tggcggcggt cggtcccgcg gtcggcgcgg tgctgtcggt
     4561 gccgctcggg ccctgggtcg agtaccgccg caaacgcccg gtgatgatcg cgacggacct
     4621 cgtccggtgc gcggtgctgc tgagcgtgcc tctcgcgtac gccctcgacg cgctcaccgt
     4681 ggcgcagctg ctggtggtgt cggtgacggt ggcggcggcc gacatcacgt tccaggcggc
     4741 cgtcggcgcg tacgtgaagg acgtcgtgcc gcggcagggg ctgctgcgcg cgaacgggcg
     4801 gctggagtcg acgacgtgga ccgcgaccat gctgggaccg ccgctgggcg gtgcggcgat
     4861 cggcctcttc ggtccggtga cgacggtggt cgccgacgcc gtgagctatc tgctgtcggc
     4921 cggtgcgctg ggcgcggcgg gcggcggcga gcgccgtccc gaacggcccg acccgcggcc
     4981 ccggctgcgg gcgggcgacc tgctcgacgg gtggcggtac atcctgcgca gccctgacct
     5041 gcgtccgctg tttctcaaca cggtgctggt caacggcctg atcatggcgt cgtcgccgct
     5101 gctggtcgtg ctgatggtcg gcccgctggg cttcgccccg tggcagtacg ggctggcgtt
     5161 cgcggtgccg tgtctgggcg ggctggccgg cgcgcggctg tcgcggcggc tggtggcgcg
     5221 gttcggggag cggcgggtgc tccgggtcgc ggggacgctg cgggcgtgct ggtcggtcgg
     5281 gcttgcgtgc gtggtgccgg gggtggcggg tctggccctg gtgatcgtga tcgagttcgg
     5341 tctgatcacg agcatgggcg tgttcaaccc ggtgttctcg acgcgccggc tggaacggac
     5401 gccggcggac cgggtggtcc gcacgctgtc ggcgtggtcg gcgaccagca aggcgtcgat
     5461 cgccgtgctg acggcgctct ggggcctgct ggcgagcttc accggccccc gcacggccat
     5521 cgctctcgcg ggcgccctcc tcctggccac cccgttgctg ctcccccgcc gcctcgacga
     5581 ggcgcgccgg gaccaggaca gcgaggcgga ggccaaagcc taggcgaggc cttgttcagc
     5641 ggtggctgag gacgttgacc acgcggccgt cggggtcgcg gacgaagaag cggcggacgc
     5701 cccactcctc gtcccgcaac gggtggacga tctccgcgcc gctctcccgg acggcctcgt
     5761 acacggcgtc cacgtcgtcc acctcgacac tgatgtcggg gtgggccggc gccgtcctgt
     5821 cgccggtcat cacgctgacc tgcgccgtcg ggttggacgg ggacgccagc gtcatgatcc
     5881 agccgtggtc catgacctct tcgaggccca gcaggccgta gaactccccg tgcctttccg
     5941 ggttctccga gtggaggttg ggcacgactc ggcggacggt catcgacggc tccctcggtt
     6001 ctgccgggtc caccgggcgg cggtcatgga acgcatgcgc cgcaccgcgc ggcgtcgggt
     6061 ggcggccctc ctcaggctag ccgtcccgcg gtcgaggcgg ccggagacga cgcccggcgc
     6121 gcgggcagtg agggcggcgg cctacgcggg caggggcgcc cgcgcgtcca gcaggccctc
     6181 gccccgcggg tccgcccaca gcccggccgg caccgtcgtg ccgtacgcct ccgtgtcacg
     6241 ccgtacctcc tcggcggacc gcatgccgac gatgacgccc gcgacgacgg ggtgcccggt
     6301 cgacgcccgg aatcacagga gccggttccg cttccggcgg gagttccgtt ccggccgccc
     6361 accgcacggt cacgcctgtg cagtgggccg tacgacgatc tcgccgacgt cgactccggc
     6421 gggctgctcg atcgcgtagc cgatggcgga ggcgacggct gaggggggca tcgcgatctc
     6481 gtcgcgcgtt ttggtcatcg cggcggcggc ctcggggctt gcgcccttgc cgacgccctc
     6541 ggtgtgggtg aagccgggtg acacgacggt gacccgcaga ccggggccgg actcctggcg
     6601 cagcccttcg gagatgacgt gcacggccgc cttggtggcc gcgtagacgg cctggggcga
     6661 cttgatgacg cgggcggcgg tggaactgac gttgacgaaa tgtcccgtac cctggcggcg
     6721 gaagacgggg agggccgcgc cgatgccgtt gagcaggccc gtgacatgcg tggcgaccat
     6781 ggcgtcccag tcgtcctgac gaagttcgtc gaacggggag acggccatgg tgcccgcgtt
     6841 ggagacgagg acgtcgaggc ggccgtaccg ctccagcgcg gtgtcggtga ggcggcgcag
     6901 gtcctcacgg cgggtgacgt cgacgacgac gccggcggcg gtccctccat gggccgtgat
     6961 gccatccacc acggcgttca gccggtcctc gcgccgggct ccgagcacca accgggcgcc
     7021 ccgcccggcg aggaggcgcg cggtcgcctc gccgatgccg ctgctggcgc ccgtgatcgc
     7081 gatgaccttg tcctggacgg tcggcatggt cgggttcctt ccctgaggtg tccgcgggtc
     7141 gtcgcgtgac ctacggtgaa agcggagaca tccccgcttc ctgcccaaac taagtgggga
     7201 cctccccact tagcaagcct ccccgggaag gaatgccgac gagatggccg accaggcgcc
     7261 ccgaccgctg cgcgccgacg cgcagcgcaa cagggagaag atcctcacct ccgccgccca
     7321 cgtgttcagc acggaggggc tgaccacgca catggaccgg atcgccaagg aggcgggcgt
     7381 gggcagcgcg acgctgtacc gcaacttccc cacccgggag gcgctggtgg aggcggtcta
     7441 ccgcaacgag gtggcccagc tctgcggctc cgtcccgtcc ctgctggagc ggcacccgcc
     7501 cgaggaggcg ctgcgcgcgt ggacgcggct cttcctggac tacgtcacca ccaagcacgg
     7561 catgatcgac gccctgcgcg ccatcgcggc gacgggcgcc aacccctacg gcaacagccg
     7621 gcagttgatc cacaccgccg tgggcacgct catggacgcg tgcgcggcgg ccggcgtgat
     7681 ccgcaccgac gtccccgctt cggacatcgg cgccgcactg gagggcatcg ccctcacctc
     7741 ggcgggaccc ggccggcggg agcaggcgga gcggctgctc gacctgatac tggacggtct
     7801 cacggtgcgc cggggctgag gggcgctcgg gctcagaccc cggcgccctc ggccgcctcc
     7861 tcgacgcgtg cggccaccca ggccagcaac gcccgcacgt cgccggcggg cagtacggcc
     7921 gcctccgcgc gagggcgttc gaagctgcgc agcgcctcgg cgaccaaagg ctcgaaggcc
     7981 ggctcggacg cggcgacgat ctctcccgcc cggcgcttgg cgaaccagtg gccggtacgg
     8041 cagtggacgg tggcgcggca gccgttgagc acccggttgt cggccaggtg cccgtccccg
     8101 tcggcgtgtt cgcgcacaga ggcgcggagc gctgcgagca ccgtggtccg gtccggggcg
     8161 gcgatcacct cccgcgccgg cgcgccgtac agcgggagtc cggcctggtg ggcgacggaa
     8221 cggtcgatga cataccagaa gtcggacgcg tccgcggggt cgtcactgac gcgttcgggc
     8281 agggacggtc cggtgttgag gtccagcagg tagcccgcct cacccgacgg gcgggcggcg
     8341 aagtcggccg gatagacgac cagttcgagg ccggcggcgg ggcagggcag cgcctcgccc
     8401 cccccccccc gaggcgcccc cacgctgtcg gcccgcgggc gcgccccccc ggaggagggc
     8461 gccgcccccc ccgcgccccc gacaccgcgt cgcccccccc cccccgcgtc tgcctcttcg
     8521 cgcccccccg gggtcgccgc ccgcccccgc cacccccccc cccccccagc ccccccgcac
     8581 cgccgagatg tggcagctcc tcatccgcgg cctggtcccc gtcacccgcc gcgcccgcta
     8641 cctgtccctc gccgcccggc tggaacggga gcccgccccg ctgtgacgcc cggcgcgcgg
     8701 gcgcccggcg ggttacggtg agacccatgc ccgacacccc cgccggtccc gtgatcgtcg
     8761 ccgacgagcc cggcaccttc ccgtacggcg tgctggccga gcgtcacccc gcgatcctcc
     8821 gccaggtcgc cgccgacacc ccctacggcc ccgagcagcg ccgcgcgctc gacgccctgc
     8881 tggtgaactg caccgagggc gccgtcaccc ccctgcccgc cggcgcccac gaccgcgacc
     8941 gctgggccgc ttggggcatg gacgaccacg ccggccgctc ctggcacgac gtgccctggc
     9001 tgtggtccga gagctggttc taccgccaac tgctgcaggc cgtccgctac ttcgagcccg
     9061 gtccctggca gggcgtcgac cccttccgcc ccgccaagct cgccgagctc gacgcgcccg
     9121 ccacggacga ggaactcgcc gcgctcgacg ccctcgacga cctccccgag gacgaacgcg
     9181 cccgcgccct gctgcacggc tccctctggg gcaaccgcgc cgacctggga ttccgcatgt
     9241 ccgccgaggg cgccgaggag accgccgccg tccccgccct cgtcgccgac gacggcgagc
     9301 gcctgtggtc cctgctcgac ggttccccgg acggcaccct ctgcctggtc gccgacaacg
     9361 ccggccgtga actcgtcccc gacctgctgc tgatcgccca cctgctcgcc caagggcgtg
     9421 tcacccgggc cgttctgcac gtcaaaccgc acccgtacta cgtctccgac gccaccaccg
     9481 ccgacgtcct cgacgccgta cgccgcctca ccgccgccaa gggcgccgcc ggggcgtacg
     9541 gacacgccct gcgcgccgcc ctcaccgacg gccggctcga actgcgcgcc cacccgttct
     9601 cgtgcgcgcc cctgccctac gccgacatgc cggacgacct gcgcgccgac ttcgcggagg
     9661 ccaccctcac cgtcctcaag ggcgacctca actaccgccg tctcgtgggc gaccggtact
     9721 ggcccccgac caccccgttc gccggcgtca ccgcctactt cccgggcgcg gtcgccgccc
     9781 tgcgcaccct caagtccgac gtgatcaccg gcctcgcccc ggagacggag gcggcgctgg
     9841 acgcggagga gagcgggcgc tggcgcacga gcggcaccca cgcgctgatc caggtacgga
     9901 cctgagccac ccgactcccg tttccgcacg gtttcacgcg aaggtgtgat caccgggcgg
     9961 gccgcggatg cggccggagc ggcacgggta gcccccggcc atgacgcagc ccttcgaact
    10021 cccgcacttc tacatgccgc accccgcgcg cctcaatccg cacgtggacc aggcccgggc
    10081 ccactccacg gcctgggcgc gcgagatggg catgctggag ggcagcgggg tctgggagca
    10141 ggccgacctc gacgcgcacg actacggcct gctctgcgcc tacacgcacc ccgactgcga
    10201 cggccccgcg ctgtccctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggag aagtacaagc gcacccagga ccgcgtcggc ggcaaggccc acctggaccg
    10321 gctgccgctg ttcatgccgc tggagccggg gacgcccgtg ccggagccgg agaacccggt
    10381 cgaggcgggc ctcgccgacc tgtgggcgcg gaccgtgccg gcgatgtcca ccgactggcg
    10441 ccgccggttc gccgtcgcca ccgagcacct cctcaacgag tccctgtggg agctgtccaa
    10501 catcaacggg gggcggatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgccccc tggtcggccg ggctcgtcga gtacgccacc gccgaggtgc cggccgccgt
    10621 cgccgggacc cgtccgctac gggtgctcat ggagacgttc tccgacgccg tgcacctgcg
    10681 caacgacctg ttctcctacc agcgggaggt cgaggacgag ggagagctca gcaacggcgt
    10741 gctcgtcctg gagaccttct tcggctgcac cactcagaag gccgccgacc tcgtcaacga
    10801 cgtcctcacc tcgcggctgc accagttcga gcacaccgcg ttcaccgagg tgcccgccgt
    10861 cgccctggag aacgggctca cttcgcccga gaccgcggcc gtcgccgcat acgcgaaggg
    10921 gctgcaggac tggcagtccg gcggccacga atggcacatg cgctccagcc gctacatgaa
    10981 cgagaacgcc cggcccggcg cctcctggca gtctgtcacc ggccccggca cgtccgccgc
    11041 cgacgtcggc gcgctgctcg cccgcgccgc ctcggagcgg ctgcgcccct accggcacgt
    11101 gccgtaccgg aaggtcggac cgtcggtcgt cccggagatt cggatgccgt tcccgctgtc
    11161 cctcagcccg gccctcgagg gctcccggcg gcatctgctg gagtggtcgc accgcatggg
    11221 catcctcggt gagggcgtct gggacgagga caagctcgcc agttgcgacc tgcccctgtg
    11281 cgcggccggc ttggacccgg acgccaccca ggagcagctc gacctcgcct ccggctggct
    11341 ggccttcggc acctacggcg acgactacta cccgctggtc cacggccacc gccgcgacct
    11401 ggccgccgcc cggctcacca ccgcccggct gtccgcctgc atgccgctgg acggcgagga
    11461 ggtgcccctg ccggccaacg cgatggagcg gtccctgatc gacctgtggg cccgcaccac
    11521 ggccgggatg acgcccgagc agcgccgccc gctgcggacg gccgtcgaca cgatgaccga
    11581 gtcgtgggtg tgggagctgt ccaaccagat ccagaaccgc gtcccggacc ccgtggacta
    11641 cctggagatg cgccgcgcca ccttcggctc cgacctcacg ctcggcctgt gccgcgccgg
    11701 acacggcccc gcggtcccgc cggaggtgta ccgcacgggt ccggtgcgct ccctggagaa
    11761 cgcggcgatc gacttcgcct gcctgctcaa cgacgtgttc tcgtaccaga aggagatcga
    11821 gttcgagggg gagatgcaca acgcggtcct cgtcgtgcag aacttcttcg gcatcgacta
    11881 cgcgaccgcg ctgcccgtgg tcgcggacct gatgaaccag cgcatgcgac agttcgagca
    11941 tgtcgtcgag cacggacttc ccgtcgtcta cgacgacttc cagctctccg aggaggcgcg
    12001 ggcggtcatg cggggctatg tgaccgacct gcagaactgg atggcgggca tcctcaactg
    12061 gcaccgcagc gtggaccggt acaaggacga gtacctgtcc gggcgggtgc acggcttcct
    12121 gccgcaccgg tccccggcgc ccccagtcct cgtctgacgg cgggccgccg tggaatcccc
    12181 cgcgctccgc ccccggccga tgcccggcgc ccacgccgga ccgcggccgg accccgctcc
    12241 cgccgtcccc gaggagccgc ccgccgggcg cccggcgggc cggcgggcgg cggcggggct
    12301 ggccctgctg ctgaccggag ccgccctggg cgtcctggcc gccgcgtggg ccggccccgc
    12361 cccggcgtcc gggccggccc tctccgcccg gctcggggtg gaggtgaccg acgccggccg
    12421 gccgggcgcc ctggtggtcg gggtgcagaa ccccggcccc ggacacacgg ccggcctccg
    12481 cgagggcgac ctgctgctcg ccgtcggcgc cacccgcgtc ggcacggcag cggacctggc
    12541 ccgcgaggtc ttccgcatcc caccgggcac ccccgtccgc ctgaccgtcc ggcatcccac
    12601 gggcggctac cagcagctga cggcggttcc cgggatcctc acgtagcgcg gccgcgaggc
    12661 gcgggtcccg cggcggcggc cggccgcgcg cgtgtctcgc ccacgggaac tgggagccgt
    12721 gccgtcgcct gcggacaccg gtgcacgcag gacggacggg gagagtgggc gcacgcggca
    12781 tgtcgtccgc gggctgtccg gtgccacacg gcttgccgcg tgcctgccgg acgcggcgac
    12841 gtccgtgggc cagggcctcc gtgcgcccac ccctcacggg cggcgccgcc ggtgcgctgt
    12901 gtgcccgtcg gcggcgatgt gcgggacggg catgtccggc ttgcctggcg tgccgagcgt
    12961 ccggtgagcc gtccggtgct cctggtggca cggtgtgcct ggccgggctg tccgggaggg
    13021 cgctccggct tcccgggtgg cggtgacagc cctgccgcgg cgcgtggcgc gtccggcggg
    13081 cgctgtgggt ggcgaccggc gtggggccgg ggcggagcgc cccgcgtgca cgccggtgcg
    13141 cggcgggggt gcggcccgtg aaagcgcggc tttgcaggcg ccccggggcg tccgaccccc
    13201 gcgccgtacc ggaaggggtg caggcgatcc cgcctccgca cggggtgact gcgggggcaa
    13261 ccccggcaac cggctcgcgc cgtacccgtt cggcgggcag gatgctgccc gtagccccga
    13321 cgtccgccct tgggaggcac ccggatgacc ggcaccgcgc ccgtgccctt cactgccgac
    13381 gactacaagg accgtatgga ccgggcggcg cggcaggccg ccgacgccgg gctcgccggg
    13441 ctgctcgtcg cgccgggccc ggacctggtg tggctcaccg ggtacgcgcc gcccgccgtc
    13501 accgagcggc tcaccctgct ggtcctggcc gccggccggg aacccgtcct cgtcgtcccc
    13561 accctggagg ccccggacgc cgagaaggcc accggcgcgc ccgccctcgc cctgcgcgac
    13621 tggaccgacg gcaaggaccc ctacgccctc accgccgccc tcctcgacga ccgggggcgg
    13681 ttcggcgtca gcgacaacgc ctgggcgctg cacctgctgg gactccagca ggtgctcccc
    13741 ggcacctcgt acgtctccct caccgacgcg ctgccgatgc tgcgcgccgt gaaggacgcc
    13801 gcggagctgg agcggctcgc cgcggccggc gccgccgcgg acgccgcgtt cgaggagatc
    13861 aggaacgtcc gcttctccgg ccgtccggag tccgaggtgg ccgccgacct cgccgcgctg
    13921 ctgcgccgct tcggccactc ccaggtcgac ttcaccatcg tcgcctccgg ccccaacggc
    13981 gccaacccgc accacgaggc cggcgaccgc cgtatcgggc gcggcgacat ggtcgtcctc
    14041 gacttcggcg gcctgaagga cggctacggt tccgacacct cccgcacggt gcacgtcggt
    14101 gagcccaccg aggaggagcg ccgggtgcac gacctggtgc gcgaggcgca ggaggccggc
    14161 ttccgcgcgg tgcggccggg cgcggcctgc caggacgtcg accgggcggc ccgcgcggtc
    14221 atcgccgacg ccgggtacgg cgagtacttc gtccaccgca ccgggcacgg catcggcgtc
    14281 accacccacg agccgccgta catgatcgag ggcgaggagc ggccgctcgt ccccggcatg
    14341 tgtttctccg tcgagccggg cgtctacctg ccgggtcggt tcggggtgcg gatcgaggac
    14401 atcgtgaccg tcacggagga cggcggacgg cggctgaacg acacggagcg ggggatggtg
    14461 atagtcgact gagcggcacc gaccggcccc tcggccccgt ccccaccctg cctctcccga
    14521 acggctacgg cgcgaccatg acccaggcac cgacacccac cgttgacacc gtccgccgac
    14581 tggcccggtc cctgctcgag gacagcgggc acggcacggc cgcgtccgcc gccgccctcg
    14641 acgtgcggct cgcgggcgac ggcgccgacc ccaccacctg gctggtcggc acccggtacg
    14701 tgctgcacct cgccccggac cgcgcgaccg gcgtgcggtg gcgccgcgag ctgcgactgc
    14761 gcgaggtggt gcgcccgcac gtgtccgtgg cgctgcccgt cggggtggcg cagggcgagt
    14821 gggcgcccgg cctgccgtgc acgctggaga cccggctgcc cggcggcacg gcggaggaga
    14881 acaccgtgtc cgccgtcggc gagaccgacc tggcgggcct gctcaccggg ctgcaccagg
    14941 tgccggtacg gcaggccgag gcgctgggcg tgccccgcgt gccgccgcgc tcgctggaga
    15001 ccctgcggcg ggcggccggg gaagccgtcg aactgctcga caaggccgac gagttcgagg
    15061 cggcgcggct gcgccagttc acccaggccg cgacggtgca gctcgccgcg caggccggct
    15121 cggtggtgct ggtgcaccac gccctcacgg gcggcaacct ggtcgtcggc gtggacggcc
    15181 gggtgagggg ggtgctcggc tgggacacgg cggtggtcgg cgacccggcc gaggacatcg
    15241 cgggtctggc ccgcgccgtc ggcgcccccg cggccgtccg cgcggccacg ctggcgggct
    15301 acggcgcccg cccctgtctg cgcggcctgt ggctggcccg ctgcgactgc gtcatccacc
    15361 tcgccgaggc gctcgtccac aacgccacgg cgtccctgcc gctgctccgc acccgcctcc
    15421 gccgcgcctg ggagcccatc atgctggaac gcgtcaccga cctccgggac agcgacgcgg
    15481 cgccgtgacg cggcgcaccg cgggcgtccc ggggcgcgga gcgggcggac ccgccccgcg
    15541 cccgcctcac tcctggagca gcaccaccgc cgactccccg ggcagccgca gcagaccgtc
    15601 cgcgcccggc acgtccaccg gctcccacgc cgccaggacg cgggcctcgc gggagcccag
    15661 ggggatgtcg gcaggttcgg cgcccaggtt cacggccacg cggacgtcgc cgcggcggaa
    15721 ggccagccag cgccggtcct cgtcgtaggc caccttggtg tcggcgaggt ccgggtcggt
    15781 gaggtcgggc tgctcgcggc gcaccgcgag gagctgcccg taccaggcca gcatccgcgc
    15841 gtgcggctcc cgctcacgct cggaccagtc caggcaggag cggtcgcggg tggccgggtc
    15901 ctgcgggtcg gggacgtcct gctccgccca cccgtgcgcc gcgaactccc gccgccgccc
    15961 ctggctgacc gccttcgcga gctccggatc ggtgtggtcg gtgaagaact gccacggcgt
    16021 gcccgccgcc cactcctcgc ccatgaacag catcggggtg aacggcgcgg tcagtgtcag
    16081 cgccgccgcg caggccagca ggccggggga gaccagcgcg gacagccggt cgccctgggc
    16141 ccggttgccc acctggtcgt gcgtctggct gtagcccagc agccggtgcg cggccacgcg
    16201 ggtgcggtcg agcggacgcc cgtggtgccg gccgcggaag ctggagtagg tgccgtcgtg
    16261 gaagaagccc ccggtgagcg tcttggccac ggccgccagc ggggcgcgtg cgaagtcggc
    16321 gtagtagccc tgcgactcgc ccgtcagggc ggtgtgcagg gcgtggtgga agtcgtcgtt
    16381 ccactgggcg tggatgccga ggccgccccg gtcgcgcggg gtgatgaccc gcgggtcgtt
    16441 gaggtcggac tcggcgatca ggaacagcgg ccggccggtg tcggcggcca gctcgtccac
    16501 ggcctgcgac agctcctcca ggaagtggcg cgcgcgggtg tccaccagcg cgtgcaccgc
    16561 gtcgagacgc agcccgtcga tccggtggtc gcgcagccac gccagcgcgc tctccacgag
    16621 gtacgcgcgc acctcgtccg agccgggcgc gtccaggttg accgccacgc cccacggcgt
    16681 gtggtgcgtg tcggtgaagt acgggccgaa ctgcggcagg tagttgcccg acgggcccag
    16741 gtggttgtgc accacgtcca ggacgacgcc gagccccagc ccgtgcgccc ggtcgacgaa
    16801 ccgtttcagc ccctcgggcc cgccgtacgg ctcgtgcacg gcccacagcg agacgccctc
    16861 gtacccccag ccgtgccggc cggggaaggg gcacaccggc atcaactcca cgtgggtgac
    16921 gcccaggtcg gcgaggtggc cgagccgttc ggcggcggcg tcgaaggtgc cctcgcgggt
    16981 gtaggtgccg acgtgcatct cgtacagcac cgcgccgggc agcgggcgtc cggtccattc
    17041 ggcgctccac tcgaagcggt cgtggtcgac gacggcgctg agcccgtcgg ggccgtcggg
    17101 ctggcggcgc gacctcgggt ccggcagcac cggaccgtcg tccagggcga agccgtaccg
    17161 ggagccgtcg tgcgcctcgg cctccccccg ccaccacccc tcccgctcgg gatcgcgctc
    17221 catcgcgcgc gtgacgccgt cgcaccggag cgtcactcgg ccggcctgtg gtgcccacac
    17281 ctcgaactgc acggacggtt ccccttcgtc tgctcaccgt gatgaagcgc ctccatcgtg
    17341 cggcatcgga gatcaatacg ccgggggatc cgccgttttg cggcgggtgt cgcccgaggt
    17401 gtgcgtgccg gggccgtggg gggagcgggc gtaccccctc acaggcgggg gcctgtcctc
    17461 cgtttacggg gtttctggac agctcgccct cggctgcccg acaatcgacc gcgtgacgtc
    17521 gtccttcgag ttctccacgt accccgcgcg gctctccgac gcggagcgcg acaaggcgct
    17581 gagtgtgctg cgggacggcg tcgccaaggg ccgcctctcc cacgacacgt tcatccggcg
    17641 catggaactg gcgctcgtgg cgcggcgcgc cgacgaactc accgcgctca ccgccgacct
    17701 cccgcgcgag agccgtctct cgcgcgtggt gttcggctcg gtggaggcgg tctccgggtt
    17761 caccgtgcgg ctgcgccgtg cctggcgggc cgagaagctg ccgaagctgc tgctgccgca
    17821 ccccgcgcac ggacacccgc tgcggatagg gcgcgacccg gccagcggac tgcggctcac
    17881 ccacgagacg gtctcccgcg tgcacgccga actcacccgt cagggcggcc tgtgggtgct
    17941 gcgcgacctc ggctccacca acggcacaac ggtgaacggc cgtcgggtgg tcggcgcggc
    18001 cgtggtccgc gagggggacc aggtgggttt cggccggatc gtttaccgtc tctccgtcaa
    18061 ctgacgggcg cacacatctc gttgggccgt acgtgtatac atctcgtcgg gcatgagggt
    18121 gttgacgccg cccgtacgtc gcgggcgtgc ccgacgcgga ccggctgctc gccccggtcg
    18181 aggaccacct cctggtctgc ccgggcctcg cggacgcctg ggactccgac cgcgggacga
    18241 ttctgtgcgt ccgctgccgc ccatgacggc cgcccgcccg gccgagctgc gcctcgtggg
    18301 aaggcgcctc gcctgcgcac cgccggtctg ccgcaccagc tcgtcacccg cgccggacac
    18361 gacccggccg acgcgctgcc cgtgctgaac cggctgacgg acgcgcgtcg cgcggacctc
    18421 cgggacacgc tcggcgcccg ctggatcccc gtggaccgcc aggcggagta ccaggcccgg
    18481 gtgatccgcg ccgtgtgcgc cccggccgta cggaggacac ccggagcctc ccgttcgggt
    18541 gagccgggct ggggtcccgg gcccgccgtg ccgatgcacc gggaatgacg cacacctcag
    18601 tgaagacggt aggggcgggg ctgtccgccg ccgccctcct cctgctcgcc ggcgcgacgc
    18661 ccgccgccca cgcggacacc tcgccggaac ccgggaactg gctgatgctc agcgtgagtc
    18721 acggggaggc cccggcggcc ggggcggagg gcggcacgct gctgcggtgc gacccgcccg
    18781 gcggcggcca cccgcacgcg gaggaggcct gcgcgcaact gtcggccgcg gacggccgca
    18841 tcaccaccct ccccgcggag aacaccctct gcccgatgat ccacgccccg gtgacggccc
    18901 acgcggaggg cgtgtggcgc gaccgcccgg tcacctggtc ggagaccttc ccgaacacct
    18961 gcgccctgcg tgcccacacg ggggcgctgt tcgcgctcga cgggacgtga gacgcagggt
    19021 gccgtccggc gggcgcggga ggacaccccg gccggcgggc ggccccgggg tgagggggag
    19081 ctgaccctga cggcgagtga ggccacccgg ggcgccgccc gacgccgggg ccctggggcg
    19141 tcggacagcc gacagcccgc cctgctgtcc ggctcgcgcc gggtgcttcg gcgctccttg
    19201 ttgggatggc cggggcgggg ttgacggtgt ctgcatgggg catggtgttc ggccgtgagg
    19261 gtcgggtggc cgggagtcct gagggcggcg ccccgcaccg gagggggcgg gacggctgcc
    19321 ccgcgtcccg accggccggg gcggcgtgcc gccccggccc cctcacatca gccccgcccg
    19381 cgcctgccgt gccgccgcca ccaccgtgcg cgactggtgt tccacctggt ggcggaccgg
    19441 gacccagcgg gcgcggaagc gggtggcgaa ggcgtcgctc cagtgggcga ccaggtggtc
    19501 caggcgggcc gccgcctggg cgccggcgtc gcgcagcgcg cgccgcagca tcgccgccgc
    19561 ccgcagcggc acgcggcgcg cgaaggcgtc cacgctgccg acgtaggcgc gggtgccgtc
    19621 cgcgggaggg gtgcggacca ggtcggcggc cagtcccggc accagctcga gcacccaggc
    19681 ggccgcccgc agcagcggac cgtcggcctc ggtgggcggc ggccccggcc gtacgtcctc
    19741 cagcacgtgc cgcaccgcgt ccgcgtcccg cagcagccgt tccgcgagcg cgtgcatcgc
    19801 ggtgtccggc gccgggtgcg gggccgggtc gtcgaccagg tcactcgccc acatcggtac
    19861 ctcgaccacc gcggtcagac cgccgtaccg gtgcgcgtgg tgccaggtgc tgtgccgggc
    19921 gtcgtcgctc aggctcggat aggccggggc cgcctccggc gcgggcatca cgtgcacgcc
    19981 gggacccgac gcgggccagc ccgccgcgtc cgaggcgccc gtctcgacgg ggatgtgcag
    20041 ctcggccgcc gacttggcga acggctccgc gagcccgggc acgtcccgcg tcaactgcac
    20101 ccagctgccg cccagatccg tgccgtgcag ggacacctgg aggaacggcc gcagctcgtc
    20161 gatcaccccg gtcagcgccc gcgtctccgg gggcagccgg tcggcgggca gcaccgaggg
    20221 cgcccactcc ggctgctcgt ggcctgccgg gcggaagaag cccaggtggt agtcgtacag
    20281 gctgcgcggc gcgggcgtga cgtgcaggct cgccccgtcg gggtccgcgc acagcaggaa
    20341 gtgccaggag acgccgtcgc gcagctcccg ctcgagcagg gtccgccggg ccagcgccag
    20401 cagcgtcccg ttgcccgcgg gctcgttggc gtgggcgccg gccacgacca ggacggcgtg
    20461 ccgggcgcgt cccacggaca gcaggtgcag cggccgcccc ccgcgggaca cccccacctg
    20521 ccgcagcaca cacagccccg gccactggat cgccagcgcc cgggcggaga agaccagttc
    20581 ggccaccgtc ggataacgcg actcccgcag cggacccacc ccccgtcacc gcccgcactc
    20641 gcactgcgca gtaccccacg gccgggagac ggtgtcaagg gcggtgcggg ggagccgcca
    20701 gggggcgctc agaggcacac cgcggccctc ttcccgcacg tcggccgtcc cgagcccgcc
    20761 acgcgtcccg cgggtccgca ccggccgtgc ggcgaccgcg caccgtcctg cacagcgccc
    20821 ctgcggtcgg aaccaccgtc acccgggcac ccgcggtcgg aaccaccgtc acccgggcac
    20881 ccgctccagc agcaccaccg gcgacgcggc gaacagctcc tccacccgca cgtccccctc
    20941 gaactcccgc cccgacgcac ggacatcggc ccaccgcccc gggggcagcg gcaaccgggt
    21001 gtcgccccag ccgccggcct ccgcgagacg cagcgagagg cgggtcaccg ccgtgaccac
    21061 cgcgccggag cgggcgaacg ccaggcagtg gtccgccgcc ggaccctcgg ccgtcagcgg
    21121 ctcgtacgac gccgtcgtgc cgaagacgtc cggccgccgc gcccgcagcg ccagcgccgc
    21181 ccgggtcacg gcctccttct ccccgccgtc cccgctgtca ccgccgtcct tgccgaaccg
    21241 cgggggccgc cggttgtccg ggtcgaccag cgcccggtac tcgcgctcag tgccctggta
    21301 gaggtcgggc acgcccggca tcgtcaggtg cacaagcgcc gcgcccagca cgttcgcccg
    21361 gatgtgcggc tccagcgcct cccgcagctc cgcgaccttc cgccccggca ccccgcacgg
    21421 acccgccgtc acgaaccgtg ccaccgcctc ctcgtacggc ggttcctgct ccgtccagct
    21481 ggtgaacagg cccgcctcgc gcacatgctt cagcagcgcc gaccgcaccc gctcctcctc
    21541 ggcggggccg agcccgaaca ccgtctgcca ggccgcccac gccgtctgcc cgtcgggcac
    21601 cgcctcttcg gcgcgggacg cctcggcgac gacgtccgcc cagcgctccg ggcactcggt
    21661 gagcacgtgc agcgccgccc gcacgtccgc gctgcgcttg gcgtcgtgcg tggacagcac
    21721 cgtcccggtg gccggccagt cgcgctgcac gcgcgcgcag tacgcgtgga agcgcaccgg
    21781 gtccaccgcg gggtcgcccg gctcgccgcc cacctccgtc gccgacagca gcggcacgta
    21841 gcggtagaac gccgtgtcct ccacggactt ggcccgcagc gccgacgccg tctgcgcgaa
    21901 ccgcgtacgg aactcgacgt acgcgggccc gtccccgtac cgcccgagca gcaggtcccg
    21961 tacgacgtcg accgcgcccg cctcctccgg gacggcgaac gcgcgccgtg cctcggccgc
    22021 ggcctcctcg gtcaccaccg tggccgcgtc ctcgggggag tagggccggt acacctccag
    22081 ccgcaccagc agctcggtca gcgcggtgcg cagcgcccag ggcgcacggt cccgcagcgc
    22141 ggtctcgggg gcggtcg
//
