LOCUS       NZ_RCDD01000007        17942 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Actinokineospora cianjurensis strain DSM 45657 Ga0180969_107, whole
            genome shotgun sequence.
ACCESSION   NZ_RCDD01000007
VERSION     NZ_RCDD01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora cianjurensis
  ORGANISM  Actinokineospora cianjurensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 270086)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 270086)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003663795.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:08:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,669
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,552
            CDSs (with protein)               :: 6,552
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 10 of 54
            Pseudo Genes (incomplete)         :: 50 of 54
            Pseudo Genes (internal stop)      :: 2 of 54
            Pseudo Genes (multiple problems)  :: 7 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 252144
            Orig. end                         :: 270086
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RCDD01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17942
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..17942
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17942
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:15175](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15175
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    460..475
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.24"
                     /tool="antismash"
     gene            complement(547..759)
                     /locus_tag="CLV68_RS29610"
                     /old_locus_tag="CLV68_5995"
     CDS             complement(547..759)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5995"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_246010173.1"
                     /transl_table=11
                     /translation="MLKWRLAAPKGADPAGDWFEVGFIKHSDGVTYTVMRKSQEPGGTV
                     LVYTPMEREACLAGAEDGAFDGPWQ"
     gene            1209..2354
                     /locus_tag="CLV68_RS29615"
                     /old_locus_tag="CLV68_5996"
     CDS             1209..2354
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5996"
                     /product="DUF932 domain-containing protein"
                     /protein_id="WP_121394298.1"
                     /transl_table=11
                     /translation="MTTTELAPFTRRPRLSIESLIAKLRAQDSRKQDMVVPAHKMRVTP
                     EGLLELDEPRITSNGVSDTSHFQLTGTFDSGIAGKLKVPANYLARMREYNQLPLLADNV
                     NTWLAMEPNRPFLVRTFQGDDDQPGVGRALLSDSYGIRDNLPLLMAVLEGIADRGAEVE
                     ITGELTDRRMIVKIVAPRVTTEATDLLRFYRSPFTGRTGADNPVVAAGVVLTNSELGFG
                     ASTITPQFTVQICTNGLTVTKDAMRTIHNGTKLEHGVIQYSEETTKRELATATSRARDA
                     VRTFLNVDYMVRKLNEIAGKAHVDVIDPEATIQHVGKIVGYTGEQQNRILAHFIRGADT
                     TAGGVLHAVTSAAQTLVDADAAYELERTGLRALEVAASYQR"
     gene            2461..2940
                     /locus_tag="CLV68_RS29620"
                     /old_locus_tag="CLV68_5997"
     CDS             2461..2940
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5997"
                     /product="hypothetical protein"
                     /protein_id="WP_121394299.1"
                     /transl_table=11
                     /translation="MSAFLVDVEHIDALLTAGLVYGRDRSPLTWYYPMPESGQPEDLSV
                     LAHQLSPASAGRIGAMLLAENVRSVNHAHQRDQWEPPYLFQELPGQPDPVVVLKAISCL
                     QNQSCEHPGWPDSEAYAFLDALHRMTVTQLPGWRELSNSAWPIQDRLIFDHPRPA"
     gene            3049..3237
                     /locus_tag="CLV68_RS29625"
                     /old_locus_tag="CLV68_5998"
     CDS             3049..3237
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5998"
                     /product="hypothetical protein"
                     /protein_id="WP_121394300.1"
                     /transl_table=11
                     /translation="MSATTLKSVSRNPLNLWRDPATNHVMGDGQIEWCGLRIYCTCARW
                     YAEHEGYLLECGSRNCR"
     misc_feature    3205..3207
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3431..3781
                     /locus_tag="CLV68_RS29630"
                     /old_locus_tag="CLV68_5999"
     CDS             3431..3781
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5999"
                     /product="hypothetical protein"
                     /protein_id="WP_121394301.1"
                     /transl_table=11
                     /translation="MPSAPSRSTHTALTRESSITEPKRIDPPDCGCTDCLTGYSRPLSP
                     WGDDDQFAALLHGQADNATGVELADLHLVLNPAGRESFGQFLSTELRAGRLVSRPRIEG
                     KALSRVLGDLVD"
     misc_feature    complement(3467..3482)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            3803..4597
                     /locus_tag="CLV68_RS29635"
                     /old_locus_tag="CLV68_6000"
     CDS             3803..4597
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6000"
                     /product="hypothetical protein"
                     /protein_id="WP_121394302.1"
                     /transl_table=11
                     /translation="MPGAELAWHAAGVDATKFTARHRETAWLPADDLSGVGASEGVIIR
                     AAKLDLGPTKAAAETGRDRRVELGLLTGDAAGLTPLAPVDEHALAELAASAGDRGEQDG
                     GDAELPEVLALLADALAEDERGIASTAEMAARIGWDARTLGEALRRSSVSAPRPPRQRV
                     SGAKHPVSVQSIDTIIAAIVDHGGWARTGVPMACAGHRSSRTPLDQRRCMLCGLAGCAG
                     RPAHPANPHNPAVRGRVQRSSGRSQLCTTITLVLGSWPCLTR"
     gene            complement(4519..4878)
                     /locus_tag="CLV68_RS29640"
                     /old_locus_tag="CLV68_6001"
     CDS             complement(4519..4878)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6001"
                     /product="hypothetical protein"
                     /protein_id="WP_121394303.1"
                     /transl_table=11
                     /translation="MTQAEVKTTKPNVVHQAIDLKRCEGVWTCDDLSELVPDVPVRRRF
                     PTMAALLDDVFRHVAERELYHMKRDGSAEIVIMLLEPTFEVLAKNIRFRYLVKHGQDPN
                     TKVIVVQSWLRPLER"
     gene            complement(5031..5156)
                     /locus_tag="CLV68_RS35825"
                     /old_locus_tag="CLV68_6002"
     CDS             complement(5031..5156)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS35825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6002"
                     /product="hypothetical protein"
                     /protein_id="WP_281274712.1"
                     /transl_table=11
                     /translation="MPTRWAEKLPARRHRARLLCQRHADLMLGTRDPGQADEQHE"
     gene            complement(5224..5556)
                     /locus_tag="CLV68_RS29650"
                     /old_locus_tag="CLV68_6003"
     CDS             complement(5224..5556)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6003"
                     /product="hypothetical protein"
                     /protein_id="WP_121394305.1"
                     /transl_table=11
                     /translation="MTSRLELDLPAGNDTLPFTDLAGFVDHVRAAGANADTPVVAVAAE
                     QDESILIALRVELDGLAARPATIAVDRADIKDLLTEIDDNDGDTRSHQQTVRELRQRLT
                     GLALGS"
     gene            complement(5614..6945)
                     /locus_tag="CLV68_RS35830"
                     /old_locus_tag="CLV68_6004"
     CDS             complement(5614..6945)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS35830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6004"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_121394306.1"
                     /transl_table=11
                     /translation="MSGEPNDLLRAAREAANMTQGQLAELANTQVEQATGTAGAMDADY
                     IGKLERGIHRWPNRQYRAALRQALHRSSDGDLGFFSTRSRAATVESPRPPHDGGDDVER
                     KTFLRVLTGSVAGMAFADPLGAFVATALPGTPPRRVGQAEVDQVRHLARMFATQDHLFG
                     SGLSAEAVVTQLSTSAQLLHGRVATELVRQRLFSAVADLADIAGGMCFDAGDHAKAERC
                     FRFGVGAATEAGDWAMRGKALSGLANLAVHQGRPDDALSFAETALVRADRLTPVVKAVM
                     HTRHARALGLAGPHRETDCLTATGQAQDAFARTGGDEPDWIAYYGPAHLERDLGRALLH
                     LAVNGGDHTAAQAHLVAAIDRFPQQQSRGKTLAMANLAHLTMARDDPNHAATLGHNALD
                     DLGPIRSDRVFEALRQLRIAGRRHRTIPAVRELNARIDRALKPA"
     misc_feature    complement(6550..6552)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7276..7641
                     /locus_tag="CLV68_RS29660"
                     /old_locus_tag="CLV68_6005"
     CDS             7276..7641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010312388.1"
                     /locus_tag="CLV68_RS29660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6005"
                     /product="hypothetical protein"
                     /protein_id="WP_121394307.1"
                     /transl_table=11
                     /translation="MDEARTPITEADAVSHYPELAHLVGVRDAGWVFRPLHDQHDQLMG
                     LAGSRSVDQYTDAIYLFDRSHVIAARVQAEEYGGGCVWMRDGTDVAEVVTDLLGLPELG
                     APGAPSLVISQSLLWAP"
     gene            7793..9721
                     /gene="fxlM"
                     /locus_tag="CLV68_RS29665"
                     /old_locus_tag="CLV68_6006"
     CDS             7793..9721
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="CLV68_RS29665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6006"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_246010174.1"
                     /sec_met_domain="PCMT (E-value: 1.8e-42, bitscore: 139.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFALFASIVVAACLAGFGGRLARDVLRQRRSRAAAIRLALRYSPA
                     PVVMGRHDGHSDEAVSVADLLIRAAEQGRALRLNWSVNDTDPHGLATPTADDWPTGVLP
                     RIEDDMPDPRTTGPSLSCPVASRAASRIRCGRCRSRPTPTCWTASCEACGGWSDQLGCR
                     GAPAHCETATADPGAEGGVWSMLLPPLGCAAQLSVRARPSPPTRARPQTGGNRLEENWK
                     SDRVNTLRDDSSVADATSTPDELRAAMVAEMRRQGDFSSSEVEAAFARVPRHLFAPNET
                     AEAAYRRNDIVERKYDADGLVTSSVSAPWLQATMLEQAELRPGMRVLEIGSGGYNAALI
                     AELVGETGQVTTLDIDAEIVERSRRCLDAAGYPHVAVILGDGEHAAPGRAPFDRIIVTA
                     GAWDIPPAWIDQLAQDGRIVVPLRVRGLERSFVLARDGEHLVSTGHRLCGFVSMQGEGA
                     NRERLTLLRGEEVALRIDGENPADPEGLRAALDMPRVEVWSGVEVGGFEPFHEMDLWLA
                     SQAEHFALLVAQQSARDSGLVSPGTRMGAKTVIDGATFAYRAHRPTSPDRSSFEFGVYA
                     HGPDAQRLAEDYAELIRAWDRDHRHGPGAHIDVWPAGTPDADLPHGRVIDKQHTRVSIS
                     WPQDSAS"
     misc_feature    complement(7803..7818)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.55"
                     /tool="antismash"
     misc_feature    complement(9749..9763)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     gene            9766..9921
                     /locus_tag="CLV68_RS29670"
                     /old_locus_tag="CLV68_6007"
     CDS             9766..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="CLV68_RS29670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6007"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_121394308.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.5e-15, bitscore:
                     50.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAQLTPTNGSALDLDLTIVESAPVIPALMGNTDDNCGSSCQSAC
                     SNSDCE"
     CDS_motif       9766..9849
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTAQLTPTNGSALDLDLTIVESAPVIPA"
                     /locus_tag="CLV68_RS29670_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9850..9921
                     /prepeptide="core"
                     /locus_tag="CLV68_RS29670_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-2.60"
                     /molecular_weight="2233.3"
                     /monoisotopic_mass="2231.8"
                     /core_sequence="LMGNTDDNCGSSCQSACSNSDCE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAQLTPTNGSALDLDLTIVESAPVIPA"
                     /leader_location="[9765:9849](+)"
                     /alternative_weights="2251.3"
                     /alternative_weights="2269.3"
     gene            10001..13072
                     /locus_tag="CLV68_RS29675"
                     /old_locus_tag="CLV68_6008"
     CDS             10001..13072
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="CLV68_RS29675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6008"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_170224664.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-183, bitscore:
                     604.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.9e-18,
                     bitscore: 58.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.5e-35, bitscore:
                     114.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRALDAAIVRTAAHPANLTVPPWPDLTADRAGQVSGWRDWLERV
                     WAITTFADAVTDASPVLARQARRVIDGHELRARQVRRTVVSTLRYLLRATGRATPFGLF
                     AGIAPARFGTLTTVAHSGVPRLVARVDGGWLAAVITRLEACDPLRQRLSVAVTDVRWLR
                     DGRLITGLRQAPGAATGQQPAEVSLRHTPAIDLIVEAAGKPILVAELADTVAAKFPATP
                     HPAIDDVLAHLITERVLISNLRPPMTTADPLAHLLAQLNRVDADQFPQARPIVQDLREI
                     AALLAQHNAAPAPGVRETVTAAMTRVAAVERPLMVDLRGDLALTLAQMVTREAERAATA
                     LSRLTPHPFGSPVWRDYHSRFLERHGVGAAIGVLDLIHPGTGLGFPAGYRDSLLDRPAT
                     GLTERDTRLIALAQRAALARTVEVTVDETLLTDLETQDRATAAAQPHTELAFRLHAATP
                     AAVDRGEFTLVVAGVFRAAGATTGRVLDLLDTADQQRITDVYAGLPTVRDGALRAQMSC
                     PPLFAATENVARHPAVLANTLPISEHRAPTTGRVDLDDLVVVGDPHRLVLWSQSQQRPV
                     EPALFSAVEFTNFTHPLARFLAELPTARTATCAAFAWGPAATQLPFLPRLRNGRTVLAV
                     ARWIVTAADLPGPAPTWPEWVDGVGRWRERAMVPDTVFLGSTDQRLPLNLTEPAHLRLL
                     RDAIDRHGRATLHEAPTSSELGWIGGHAHEIIVPLAATSAPAPARTMPVHPIDPDHGHL
                     PGAGRWLYAKLFAHPDRHTAVLGHLPTLLSTWDTPPPWWFLPYRDPDHHLRLRVRLTTP
                     DEFGQAARRVGDWAARLRGLGLISGLQLDTYQPETGRFGPAAAMAAAEAAFAEDSAAAL
                     AQREHRTVVSAADPLAVTAASLVDITASFLGDIAAGMRWLTDHLTTDSAPAPDRRIHTQ
                     ATRLSDPTDEWAALRAQPGSAELIGTWQRRSTALAAYRAILTTAGISPDTVLGSLLHLH
                     CLRANGINPDTERVCHRLARAAALSWTARTRGTQ"
     aSDomain        10484..10738
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CLV68_RS29675_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-18"
                     /identifier="RREFam001.1"
                     /label="CLV68_RS29675"
                     /locus_tag="CLV68_RS29675"
                     /protein_end="246"
                     /protein_start="161"
                     /score="58.5"
                     /tool="antismash"
                     /translation="LRDGRLITGLRQAPGAATGQQPAEVSLRHTPAIDLIVEAAGKPIL
                     VAELADTVAAKFPATPHPAIDDVLAHLITERVLISNLRPP"
     gene            13069..14298
                     /locus_tag="CLV68_RS29680"
                     /old_locus_tag="CLV68_6009"
     CDS             13069..14298
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007024582.1"
                     /locus_tag="CLV68_RS29680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6009"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_121394310.1"
                     /sec_met_domain="LANC_like (E-value: 4.7e-44, bitscore:
                     144.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPRTVEDIVDQLARDLADPATVSTERNQHRPVPQSLANGAAGI
                     ALLHAERARTGHGDPATAHAWLAAATADGVDAGPQASLFYGAPALAFAVHAIADGTDTY
                     QRARTTLHHATAALTRARLDQAHARIDRGEPPALAEFDLLRGLTGIGAYHLRVDPHSET
                     AADVVAYLVRLTEPLPGGNGLPGWWSDLAPTGRPSPNFPHGHGNFGLAHGIAGPLALLA
                     LAKLRGLTVAGHTDAIDRILTWLDTWTQHSETGPWWPRTITPDDIDRGSPGDTLPGQPS
                     WCYGTPGLARAQQLAAIATGDTRRQADAENALLACLSDPAQLDRITGIGLCHGAVGLLH
                     ITARAASDATSTVLASHLPDLTERLLAALERDEAGSELLDGRTGAALALHAAITGTTPA
                     TRWDTCLLLA"
     gene            14321..15175
                     /locus_tag="CLV68_RS29685"
                     /old_locus_tag="CLV68_6010"
     CDS             14321..15175
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007024581.1"
                     /locus_tag="CLV68_RS29685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6010"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_121394311.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.7e-41, bitscore:
                     135.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAGLDIDTGPDDTGWAQVAVRIDDYATAEHVGTTHLGPLMASAE
                     HAGLITCWWFVRKNPYWRLRWRPVPGTAHEANHVVQRALDTLRGKGIIAETTATIYEPE
                     IHAFGGEKAMDLAHRLFHADSTHLLDHLAGDRGRGPSPGEKRRELTVLLCSNLMRAAGQ
                     DWYEQGDIWARVADNRPLPASTSADQVHAAVAGLQRLMTVDASPTSPLLQPGGSLAHVT
                     GWATAFDTAGQHLGRLARAGTLRRGVRAVLAHHVLFHWNRLGLPHDTQALIAHTAKTVV
                     LGT"
     gene            complement(15373..16134)
                     /locus_tag="CLV68_RS29690"
                     /old_locus_tag="CLV68_6011"
     CDS             complement(15373..16134)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025022.4"
                     /locus_tag="CLV68_RS29690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6011"
                     /product="PIN domain-containing protein"
                     /protein_id="WP_211346810.1"
                     /transl_table=11
                     /translation="MSRRVPDSYARRLLTELDAIESAFADVLSVSAIVDVDPNRGGRGS
                     GMVFIGFAMWGWAPSSETLEADRMALLRRVRDWGPRYRLLFPHPTPTMSKRLDKNTELL
                     ESWLVRKSGEHDVPSTMEEAAQLLGEAVADVRSLADLFPADEYAVRLAVDTNTLIDNPD
                     LAVHVATPGGKYMVRLLPVVLRELDDLKRGGKTQDLREAAKRAERRLKGLRTNGDASVG
                     VRVAGGGWRVTCVPCSSTSNPTTTVSRRGST"
     gene            16209..17168
                     /locus_tag="CLV68_RS29695"
                     /old_locus_tag="CLV68_6012"
     CDS             16209..17168
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS29695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_6012"
                     /product="hypothetical protein"
                     /protein_id="WP_211346811.1"
                     /transl_table=11
                     /translation="MARSDQTLLIRTRTLPDTAGAATSGGFGSWATAQRVAPCHGTANM
                     ILLFSDTLTEETSLYAFLTESAAQLGAPLVRVADGRTPFEVYWHSRFLGNSRLAPCSKI
                     LKQQLARRWLEVNGDPRTATLYVGIDAGETRRIPGVRAGWAPWTVQFPLTDEPELTKEA
                     MLAVARGLGLTPPAASQKGFAHANCGGLCVRGGQAHWRRRLVRHPDRFADYEHREQEFR
                     AEFGDVAILKEQRDRVVRPLPLTELRRRPQPTCTIARAAPAKAGTRLHWCAGTGEPAVA
                     CTKVTAATSIPPRGTALTARSAGTPGPPRGEAAPRHAA"
     gene            17344..17712
                     /locus_tag="CLV68_RS29700"
                     /old_locus_tag="CLV68_6013"
     CDS             17344..17712
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017148.4"
                     /locus_tag="CLV68_RS29700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_6013"
                     /product="DUF732 domain-containing protein"
                     /protein_id="WP_170224665.1"
                     /transl_table=11
                     /translation="MALRSRALAVAAVAAFSGVALSSCGLRSPRQEPAPDLTVADVLYL
                     TELRPADVELKTPDASVDYTRAGRDTCASLEKSKSVPAVAKPLASSFYPDEASVIIVAA
                     IHNYCPQHVGLLALPGRA"
ORIGIN
        1 acggtcatcg gcgccccgtg accgttaacg ctcgaccgcc tgggccaatt gaggcgcgct
       61 gcgattcaaa tcatgtgatt tgaatcgttc tcatgatgcc cttcttcgtc catcagccag
      121 ttgcgtgaac gtagcgatct acgtcatcct gaacaggctt cgagtgtcgg gtccgcactg
      181 agaccgcgcg ttgaaccatc cagctagggt gggactgtgg cttcgggtca acctctacct
      241 gcacatccac accgagcatc tgaccgagcc gacgacctcc ctggcacggc cgtggcgcgg
      301 cacgctggcg taaacgggga cgccgaaacg gctgcacgcg gtggcggagc aggagctgcg
      361 gcgtacatgg gccatcaagg ttccgaagta gcggcatcgg cccgaggctc ggcgactgcc
      421 gagcagcccg aggaatcccc atcgagatcg cacgactcaa ctgggcttga ccagtagcta
      481 cgccctggac acggctgcgc ccgtcctgct gaaggctggg cgcagccgtt tctgctgctg
      541 tgccacctac tgccaggggc cgtcgaacgc gccatcctcc gcgccggcga ggcacgcctc
      601 ccgctccatc ggtgtgtaga ccagcaccgt gccccccggc tcctgggact tgcgcatcac
      661 ggtgtaggtg acgccatcgg agtgcttgat gaagcccacc tcgaaccagt cgcccgcagg
      721 gtcggcgccc ttcggagcag cgagccgcca cttcagcacc tcgacagatt caggtgacct
      781 cgaatctgct ccttgtcgtc atcgctgcgg tggcttgctc atttgcccag ttgtactcag
      841 gcacgcccgt gagctcgcgc aggcgtgcat cgcccgccga gacggtgctt gaccccgctc
      901 ggtgggtggc agtcgcgaac tctggaccac cgggccaggc tgcgcccgat gcgccgctgc
      961 ccgcgccgac acgggtgaga cgagaccagc ccctccgggg tcgcgctccg cgcgatctca
     1021 cgccggtcgg gcgagcgcgg acgccccggc cgtcctggcc ggcggcccgg acgagccgca
     1081 ccccacccac aactgggcgg ggccagcatc accacggcga cataccgcga cgaccgcgac
     1141 cgccgtgcag cccctccctc gggtccgcca aaacccgagg tcaccaccaa cgaaggagtc
     1201 ccagcgcgat gaccaccacc gagctcgcgc cgttcacccg ccgcccccgg ttgtcgatcg
     1261 agtccctgat cgccaagctg cgcgcgcagg acagccgaaa gcaggacatg gtcgtgcccg
     1321 cccacaagat gagggtcacc ccggaaggtc tgctggagct cgacgagccc aggatcacct
     1381 ccaacggggt cagcgacacc tcgcacttcc agctgaccgg cacgttcgac agcggcatcg
     1441 cgggcaagct caaggtgccc gccaactacc tcgcccggat gcgcgagtac aaccagctcc
     1501 cgctgctggc cgacaacgtc aacacctggc tggccatgga gcccaaccgg cccttcctgg
     1561 tccgcacctt ccagggcgat gacgaccagc cgggcgtcgg ccgggccctg ctcagcgact
     1621 cctacggcat ccgggacaac ctcccgctgc tgatggcggt gctggagggc atcgccgacc
     1681 gcggcgcgga ggtggagatc accggagaac tcaccgaccg gcggatgatc gtcaagatcg
     1741 tcgcgccgcg ggtgaccacc gaggccaccg acctgctgcg gttctaccgc tcgccgttca
     1801 ccggccgcac cggcgccgac aacccggtgg tggccgccgg ggtggtgctg accaactcgg
     1861 agctcggctt cggcgcgtcc accatcaccc cgcagttcac cgtccagatc tgcaccaacg
     1921 gcctgaccgt caccaaggac gccatgcgca cgatccacaa cggcaccaag ctggagcacg
     1981 gcgtcatcca gtactccgag gagaccacca agcgcgagct ggccaccgcc acctcgcggg
     2041 cccgcgacgc cgtccgcacc ttcctcaacg tcgactacat ggtccgcaag ctcaacgaga
     2101 tcgcgggcaa ggcccacgtc gacgtgatcg accccgaggc caccatccag cacgtcggca
     2161 agatcgtcgg ctacaccggc gagcagcaga accggatcct cgcccacttc atccgcggcg
     2221 cggacaccac cgccggcggc gttctgcacg cggtcaccag cgcggcccag accctcgtcg
     2281 acgccgacgc cgcctacgag ttggagcgca ccggcctgcg cgccctggag gtcgcggcct
     2341 cctaccagcg atgagacaca ggtgccggcc gggggagcgc ccggctggca ctccaccgcc
     2401 cgttgttcct gtccacgctg cgtcgcagcg ccctcacccc gcccaggagg gccacttgcc
     2461 atgtccgcat tcctcgtcga cgtcgagcac atcgacgccc tgctcaccgc cgggctcgtc
     2521 tacggccgcg acagaagccc tctgacgtgg tactacccga tgcccgagag tggccagccc
     2581 gaggacctgt ccgtgcttgc ccaccagctg agcccggcct ccgccggccg gatcggcgcg
     2641 atgctgctcg ccgaaaacgt gcgcagcgtc aaccacgcgc accagcgtga ccagtgggaa
     2701 ccgccctacc tgttccaaga actgccgggc cagccggacc cggtcgtggt gctcaaggcg
     2761 atctcctgcc tgcagaacca gtcgtgcgag caccccggct ggcccgacag cgaggcgtac
     2821 gccttcctcg acgccctgca ccgcatgacc gtcacgcagt tgcccggatg gcgagaactg
     2881 agcaactccg cctggccgat ccaggaccgg ctgatcttcg accatccccg cccggcgtga
     2941 acccgttgtg cgccagccgc gccagaacga ctggcgcaca acgggacccg actccaccac
     3001 cccggccagc gcacccggcg gtccacacgc agcgaggagg tccattcgat gtccgccacc
     3061 accctcaagt ccgtgtcgcg caacccactc aacctgtggc gcgatccggc caccaaccac
     3121 gtgatgggcg acggccaaat cgagtggtgt ggcctgcgca tctactgcac ctgcgcccgc
     3181 tggtacgccg agcacgaggg ctacttactt gaatgcggct cccgtaactg ccggtgacgg
     3241 ctgagccgtg tccggcagcg ccgtgacgct cgctcgatgc ctcgacctga ccggccccag
     3301 cgcatgccca aacgcccggc acctggcctg ccgcggccgc gtggaccggt gatgccagca
     3361 gacccggccg aggccgtcaa gtccgcgccg ctgcgcggtc ggctgcgccg agcctgggac
     3421 tgcctcggcc gtgccttctg cgccctcccg gtccacgcac accgcgctga ccagggagtc
     3481 atccatcacc gagccgaaac gaatcgaccc gccggactgc ggctgcaccg actgcctcac
     3541 cggctacagc cgccccctga gcccgtgggg agacgacgac cagttcgccg cgctgctgca
     3601 cggccaggcc gacaacgcga ccggcgtcga actggcggac ctgcacctgg tcctcaaccc
     3661 ggcaggccgc gagagcttcg gtcagttcct gagcaccgag ctgcgcgccg ggcgcctcgt
     3721 gtccaggcca cgaatcgaag gcaaggcgct cagccgcgtc ctcggtgacc tcgtcgactg
     3781 accaatccct caacgccgtc gcgtgccggg tgccgagctc gcctggcacg cggccggggt
     3841 cgacgccacc aagttcaccg cccgccaccg cgaaaccgcc tggctccccg ccgacgacct
     3901 ctccggcgtc ggcgcctccg agggcgtcat cattcgggcc gcgaaactcg acctcggccc
     3961 caccaaagcc gccgccgaga ccggcaggga ccgccgagtc gaacttgggc tgctcaccgg
     4021 cgacgcggcc gggctcaccc cgctcgctcc ggtcgacgaa cacgccctcg ccgaactggc
     4081 ggccagcgcc ggagaccggg gtgaacagga cggtggggac gcggagcttc ccgaggtgct
     4141 ggcgttgctg gccgatgcgc tcgcggagga cgagcgtggc atcgcgtcca ccgccgagat
     4201 ggccgcgcgg atcggttggg acgcaaggac tctcggcgaa gccctccgcc ggtccagtgt
     4261 gtccgcgccc cgcccgccga gacagcgggt cagcggggcg aaacacccgg tgtccgtgca
     4321 gagcatcgac acgatcatcg ccgcgatcgt cgatcacggc gggtgggccc gcacgggtgt
     4381 gccgatggcc tgtgcggggc accgcagcag ccggacaccc cttgatcagc gcagatgcat
     4441 gttgtgcggg ttggcggggt gtgcgggtcg accggcacac cccgccaacc cgcacaaccc
     4501 cgcggtgcgc ggccgtgttc aacgctcgag cggacgcagc cagctttgca cgacgatcac
     4561 cttggtgttg gggtcctggc cgtgcttgac caggtagcgg aagcggatgt tcttggccag
     4621 cacctcgaac gtcggctcca gcaacatgat cacgatctcg gcggacccat cccgcttcat
     4681 gtggtatagc tcccgctcgg cgacatggcg gaacacgtcg tccagcaggg cggccatggt
     4741 cgggaaccgc cgccggaccg gcacatccgg gacgagttcg gacaggtcgt cgcaggtcca
     4801 gacgccctcg cagcgcttga ggtcgatcgc ctggtgcacg acgttcggtt tggtggtctt
     4861 cacctcggcc tgggtcaccg ggccgacccg gccaggtcgt gcatgagctc gtgttcgcgc
     4921 agcgccccct gctgtacgta gcggtgtcgc ttaggctctg cttgagactt cctgcgcctg
     4981 aaccaaccca tgtcgatcag ccgggcagag gagcctgtgc cctgtgacgg tcactcatgc
     5041 tgttcgtcgg cctggccggg gtcgcgggtg ccgagcatga ggtcggcgtg ccgctggcac
     5101 agcagccggg cacgatggcg gcgggcgggc agtttctccg cccaacgggt gggcatcccg
     5161 cacatccagc accgcccacc ccgggcgggc agccggtgga ccccgtgctc ggccatccgg
     5221 ggctcaggac cccagggcga gtccggtcag ccgttgccgc agctcgcgca ctgtctgctg
     5281 gtgggatcgg gtgtcgccgt cgttgtcgtc gatctcggtg agcaggtcct tgatgtcggc
     5341 gcggtcgacg gcgatggtgg cgggccgggc ggccaggccg tcgagttcga cgcgcagcgc
     5401 gatcaggatg gactcgtcct gctcggcggc gacggccacg accggggtgt cggcgttggc
     5461 tccggcggcg cggacgtggt cgacgaatcc cgccaggtcg gtgaagggca gggtgtcgtt
     5521 tccggcgggg agatcgagtt ccagacgtga ggtcatggcc agcgactcaa gttggtgcca
     5581 ccgacgccgg ccgggatcga cggtgtggcg cggttatgcc ggtttgaggg cgcggtcgat
     5641 gcgcgcgttg agttcccgta ccgctgggat cgtgcggtgg cggcgtccgg cgatccgcag
     5701 ttgccgcaat gcctcgaaga cccggtcgga gcggatgggg ccgaggtcgt cgagggcgtt
     5761 gtgcccgagg gtggcggcgt ggttcgggtc gtcgcgggcc atggtgaggt gggcgaggtt
     5821 ggccatggcc agggtcttgc ctcgcgactg ttgctggggg aaccggtcga tcgcggcgac
     5881 gaggtgggcc tgggcggcgg tgtggtcgcc gccgttgacc gccaggtgca gcagggcacg
     5941 cccaaggtcg cgttcgaggt gggctggacc gtagtaggcg atccagtccg gttcgtcccc
     6001 gccggtgcgg gcgaaggcgt cctgggcttg gccggtggcg gtgaggcagt cggtttcgcg
     6061 gtggggcccg gcgaggccga gggcgcgggc gtggcgggtg tgcatgacgg ccttgaccac
     6121 gggggtgagc cggtctgcgc gcacgagggc ggtctcggcg aagctgagcg cgtcgtcggg
     6181 gcgcccctgg tgcacggcga ggttggccag cccggagagc gctttgccgc gcatggccca
     6241 gtcaccggcc tcggtggcgg cgccaacccc gaaccggaag cagcgttcgg ctttcgcgtg
     6301 atctccggcg tcgaagcaca tgccgccggc gatgtcggcg aggtcggcca ccgcggagaa
     6361 caggcgttgg cgcaccagtt cggtggcgac gcggccgtgc agcagctgcg cggaggtgga
     6421 cagctgggtg accacggcct cggcggacag gccgctgccg aagaggtggt cctgggtggc
     6481 gaacatgcgg gcgaggtggc gcacctggtc gacctcggcc tgaccgaccc ggcgtggtgg
     6541 tgtgccgggt aacgctgtgg cgacgaacgc gccgagtgga tcggcgaagg ccatcccggc
     6601 gaccgagccg gtcagcaccc gcaggaaggt cttgcgttcc acgtcgtcac ctccatcgtg
     6661 cggcgggcga ggtgattcca cggtagcggc gcgggagcgg gtactgaaga agcccagatc
     6721 gccatcgctg gaccggtgca gtgcctgccg cagggcggcc cggtactggc ggttgggcca
     6781 gcggtggatg ccgcgttcga gcttgccgat gtagtcggcg tccatcgccc ccgcagtgcc
     6841 ggtcgcctgc tctacctggg tgttcgccag ctccgcgagc tgaccttggg tcatgttggc
     6901 ggcttcgcgg gcggcccgca gcaggtcgtt cggttcgccg gacacctgtc atccctccgc
     6961 gacgactcga ctgcccagcg tagctctccc tctggggaaa cgcgggttcc tgcggctaat
     7021 cctccgccca atcctccggg cccgacctgg tcaatccgcc gggtgcagcc ggtcttgatc
     7081 tccgtgttcg gctcggttcc ggctgccgcc cgtgctgggc aggctcgact gcggggcgcc
     7141 tggtgtcggt gcgagaccgg ccggacgagc ttcccccggg tcctgcccgc gagggtgggg
     7201 caggcaggac ggtcggaccc gatcgttccc ggcaccgggt gcccaccgac tgccgacgtg
     7261 ctggggggac ctgtcgtgga cgaggcgagg acaccgatca ccgaggccga cgcggtgagc
     7321 cactaccccg agcttgctca cctggtgggc gttcgtgacg cgggctgggt gttccggccg
     7381 ctgcacgacc agcacgacca gctgatgggg ttggccggga gccggtcggt ggaccagtac
     7441 accgacgcga tctacctgtt cgaccgctcc cacgtcatcg ccgcccgcgt ccaggccgag
     7501 gagtacggcg gcggctgcgt gtggatgcgc gacggcaccg acgtcgccga ggtcgtcacc
     7561 gacctgctcg gcctgcccga gctcggcgca cccggtgccc cgagcctggt catcagccag
     7621 tccctgctgt gggcgccgtg atgcgcgcct cgatcgggcc gtgttctcag ctgaggagtt
     7681 cgtcgtgagc accctcgcgt gggcggaagt cgtcgcggcg gccacgttcg cggtgcgatt
     7741 ggcctgctgg tggcccgacc gctgccgtcc tgccgaacca cggccgtgac ctgtgttcgc
     7801 cctgttcgcc agcatcgtcg tggccgcctg cctggccggg ttcggcgggc ggctggcccg
     7861 cgatgtcttg cgccaacgcc ggagccgggc cgcggccatc cggctggccc tgcggtacag
     7921 cccggcaccg gtcgtcatgg gccgacatga cgggcacagc gacgaggccg tctccgtggc
     7981 cgacctgctg atccgcgccg ccgagcaggg ccgcgccctg cgcctgaact ggtcggtgaa
     8041 cgacaccgac ccgcacgggc tggccacgcc caccgccgac gactggccca ccggagtact
     8101 gcccaggatc gaggacgaca tgccagaccc ccgcaccacc ggcccgtcgc tgagctgccc
     8161 cgtcgcgagc cgggcagcat cccggatccg ctgcggccgg tgccgatcca gaccgacccc
     8221 gacctgctgg accgcgtcat gcgaggcatg cggcggctgg agtgaccaac tgggttgtcg
     8281 gggtgctcca gcacactgcg agaccgccac ggccgatcct ggcgccgagg gaggagtgtg
     8341 gtcgatgttg ttgccgccct tgggatgcgc cgcgcagctc tcggtgcgcg cccgtccgtc
     8401 gccgcccaca cgggcgaggc cacagaccgg cggaaaccga cttgaggaga actggaagag
     8461 tgaccgagtg aacacactcc gagatgacag cagcgtcgcc gacgcgacca gcacgccgga
     8521 cgagctgcgg gcggcgatgg tcgccgagat gcggcggcag ggcgacttca gcagctccga
     8581 ggtggaggcc gcgttcgccc gcgtaccccg gcacctgttc gccccgaacg agacggccga
     8641 ggccgcctac cggcgcaatg acatcgtcga gcgcaagtac gacgccgacg ggctggtgac
     8701 cagctcggtg tcggcgccgt ggttgcaggc cacgatgctc gagcaggccg agctgcggcc
     8761 ggggatgcgg gtgctggaga tcggctcggg cggctacaac gccgcgctga tcgccgagtt
     8821 ggtcggcgag accgggcagg tcaccaccct ggacatcgac gccgagatcg tcgagcggtc
     8881 gcggcgctgc ctggacgcgg ccggataccc gcacgtcgcg gtgatcctcg gtgacggcga
     8941 gcacgccgca cccggtcggg ccccgtttga ccggatcatc gtcaccgccg gggcctggga
     9001 catccccccg gcctggatcg accagctcgc gcaggacggc cggatcgtcg tcccgctgcg
     9061 ggtccggggg ctggagcgct cgttcgtcct ggcccgcgac ggcgagcacc tggtgagcac
     9121 cgggcaccgg ctgtgcgggt tcgtgtcgat gcagggcgag ggcgccaacc gggagcggct
     9181 gaccctgctg cgcggggagg aggtcgcgct gcgcatcgac ggcgagaacc ccgccgatcc
     9241 cgagggcctg cgcgcagccc tggacatgcc cagagtcgag gtgtggtccg gcgtcgaggt
     9301 cggcgggttc gagccgttcc acgagatgga cctgtggctg gccagccagg ccgagcactt
     9361 cgcgctgctg gtcgcgcagc agtccgcccg cgacagcggc ctggtctcgc ccggaacccg
     9421 gatgggcgcc aagaccgtca tcgacggcgc gaccttcgcc taccgcgccc accggcccac
     9481 ctcgccggac cgcagcagct tcgagttcgg cgtctacgcc cacggtcccg acgcgcagcg
     9541 cttggccgag gactacgccg agctcatccg cgcctgggac cgcgaccacc gccacggccc
     9601 cggcgcccac atcgacgtct ggcccgccgg taccccggac gccgacctcc cgcacggccg
     9661 cgtgatcgac aagcagcaca cccgcgtctc gatctcctgg ccgcaggact ccgcgtcctg
     9721 accgccaggc ccagcagaaa cccaaccctg gaaaggaaag tcggcatgac cgcacagctc
     9781 actcccacca acggttcggc tctcgacctg gacctgacca tcgtcgagtc cgccccggtg
     9841 atcccggcgc tgatgggcaa caccgacgac aactgcggct cctcctgcca gagcgcctgc
     9901 tccaacagcg actgcgagta gccacgagac cggcggccgg tagcgggcac ccagcacggg
     9961 cccgccgccg gccgttcccg cgcctggaag gagcttgccg gtgtatcgcg cactcgacgc
    10021 ggcgatcgtg cgcaccgccg cacaccccgc gaacctgacc gttccgccgt ggccggacct
    10081 gaccgccgac cgggccgggc aagtcagcgg gtggcgggac tggctggagc gggtctgggc
    10141 gatcacgacg ttcgccgacg cggtgaccga cgccagcccc gtgttggccc gccaggcccg
    10201 ccgggtgatc gacggccacg agcttcgggc ccggcaggtg cgccgcacgg tcgtctcgac
    10261 cctgcgctac ctgctgcgcg ccaccggccg ggccaccccg ttcgggttgt tcgccgggat
    10321 cgcccccgcc cgcttcggca ccctcaccac ggtcgcgcac agcggcgtcc cccgcctggt
    10381 cgcgcgggtc gacggcggct ggctcgccgc ggtgatcacc cggctggagg cgtgcgaccc
    10441 gctgcggcag cgcctgtccg tcgcggtcac cgacgtgcgc tggctgcgtg acgggcgcct
    10501 gatcaccggg ttgcgccaag cccccggcgc cgccaccggc cagcagcccg ccgaggtgtc
    10561 actgcgccac acccccgcga tcgacctcat cgtggaggcg gccggaaaac ccatcctggt
    10621 cgcggagctg gccgacacgg tggccgccaa gttccccgca acaccgcacc cggcgatcga
    10681 cgatgtgctc gcgcacctga tcaccgaacg ggtgctgatc agcaacctcc gcccgcccat
    10741 gaccaccgcg gacccgctcg cgcacctgct cgcgcagctc aaccgggtgg atgccgacca
    10801 gttcccgcag gcccgaccga tcgtgcagga cctgcgcgag atcgccgccc tgctcgccca
    10861 gcacaacgcc gccccggcac ccggtgtgcg cgagaccgtg accgccgcga tgacgcgagt
    10921 cgcggccgtc gagcggccgc tgatggtcga ccttcgcggc gacctcgccc tgaccttggc
    10981 ccagatggtc acgcgggaag ccgaacgcgc agccacggcg ctgagcagac tgaccccgca
    11041 cccattcggg tcgccggtct ggcgcgacta ccactcccgc ttcctggagc gtcatggtgt
    11101 cggtgccgcg atcggcgtcc tggacctcat ccaccccggc accggactcg ggttccccgc
    11161 cggataccgc gactccctcc tcgatcggcc cgccacgggg ctgaccgagc gggacacccg
    11221 cctgatcgcg ctggcccagc gggccgccct ggcccgcacc gtcgaggtca ccgtcgacga
    11281 gaccctgctg accgacttgg agacccagga ccgggcgacc gcggcggcgc agccgcacac
    11341 cgagctggcg ttccgcctgc acgccgcgac cccggccgcc gtcgaccgag gcgagttcac
    11401 cctcgtcgtc gccggagtgt tccgcgccgc aggggccacc accggccgcg tcctggacct
    11461 actcgacacc gccgaccagc agcgcatcac cgacgtctac gccgggctgc ccacggtccg
    11521 cgatggggcg ctgcgcgccc agatgtcctg cccgccgctg ttcgccgcga ccgagaacgt
    11581 cgcccgccac cccgccgtgc tggccaacac gctgccgatc agcgaacacc gcgcccccac
    11641 caccgggcgg gtggacctgg acgacctggt cgtggtcggc gacccgcacc gcctcgtcct
    11701 ctggtcacag tcccagcagc ggcctgtcga gcccgcgttg ttcagcgcgg tcgagttcac
    11761 caacttcacc cacccgctcg cccggttcct ggccgagctc cccaccgcgc gcaccgcgac
    11821 ctgcgccgcg ttcgcctggg ggcctgccgc gacccagctg ccgttcctgc cccgcctacg
    11881 caacggccgc accgtcctgg ccgtcgcccg ctggatcgtc accgccgccg acctgcccgg
    11941 accggccccg acctggcctg agtgggtcga cggggtgggc cgctggcgcg agcgcgcgat
    12001 ggtcccggac acggtgttcc tcggcagcac cgaccaacgg ctgcccctga acctcaccga
    12061 acccgcccac ctgcggctgc tgcgcgacgc catcgatcgg cacggacgcg ccaccctcca
    12121 cgaagccccc accagcagcg agctcggctg gatcggcgga cacgcccacg agatcatcgt
    12181 cccgctcgcc gccacctccg cacccgcacc agcccgcacc atgccggtgc acccgatcga
    12241 cccagaccac ggacatctgc ccggagccgg gcggtggctg tacgcgaagc tcttcgccca
    12301 ccccgaccgg cacaccgccg tcctcggcca cctcccgacc ctgctgtcca cgtgggacac
    12361 accgccgccg tggtggttcc tgccctaccg cgaccccgac caccacctgc gcctacgggt
    12421 ccggctcacc acacccgacg agttcggcca ggccgcccga cgcgtcggcg actgggccgc
    12481 gcgcctgcgc gggctcggcc tgatcagcgg cctgcaactg gacacctacc agcccgagac
    12541 cggccgtttc ggccctgccg ccgcgatggc cgccgccgag gcggcgttcg ccgaggactc
    12601 cgcagccgct ctcgcacaac gcgaacaccg gaccgtggtg agcgcggccg acccgctggc
    12661 ggtcaccgcc gcgagcctgg tcgacatcac cgcgtcgttc ctcggcgaca tcgcggccgg
    12721 gatgcgctgg ctgaccgacc acctcaccac cgactccgcc ccggcacccg accggcgcat
    12781 ccacacccaa gccacccgcc tcagcgaccc aaccgacgag tgggccgcgc tccgggcaca
    12841 gcccggcagc gccgagctga tcggcacctg gcagcggcgc agcaccgcac tggccgctta
    12901 ccgggcaatc ctcaccacgg ccgggatctc cccggacacg gtcctcgggt cgctgctgca
    12961 cctgcattgc ctgcgcgcca acggaatcaa tcccgacacc gaacgcgtct gccaccggct
    13021 cgcccgcgcc gcagccctga gctggaccgc ccgaacccga ggaacccaat gacccagccg
    13081 cggaccgtcg aggacatcgt cgaccagctc gcgcgagacc tggccgaccc ggccactgtg
    13141 tccaccgagc gcaaccagca ccggccggtg ccgcagtcgc tggccaacgg tgccgcaggc
    13201 atcgccctgc tgcacgccga acgagcccgc accggccacg gcgaccccgc caccgcccac
    13261 gcctggctcg ccgccgcgac cgccgacggc gtcgacgccg ggccacaggc cagcctgttc
    13321 tacggcgccc ccgcgctggc cttcgccgtc cacgccatcg ccgacggcac cgacacctac
    13381 caacgcgccc gcaccaccct gcaccacgca accgccgccc tcacccgcgc ccgcctggac
    13441 caggcacacg cgcgcatcga ccgaggcgaa cccccagccc tggccgagtt cgacctgctc
    13501 cgcggcctca cgggaatcgg cgcctaccac ctgcgcgtcg acccacacag cgagaccgcc
    13561 gccgacgtcg tggcctacct cgtccggctc accgaacccc tccccggcgg caacgggctg
    13621 cccggctggt ggagcgacct ggcgcccacc ggccgcccct ccccgaactt cccgcacggt
    13681 cacgggaact tcggtctcgc ccacggcatc gccggtccgc tggccctgct cgcgctcgcc
    13741 aagctccggg gtctgaccgt cgccgggcac accgacgcga tcgaccggat cctcacctgg
    13801 ctcgacacct ggacccagca cagcgagacg gggccgtggt ggccccggac gatcaccccc
    13861 gacgacatcg accgcggcag ccccggcgac accctgcccg ggcagccgtc ctggtgctac
    13921 ggcacgccag ggctggctcg cgcccaacaa ctcgccgcga tcgccaccgg cgacacccgc
    13981 cgccaggccg acgcggagaa cgcgctgctc gcgtgcctga gcgaccccgc ccagctcgac
    14041 cggatcaccg gcatcgggct ctgccacggc gcggtcggcc tgctccacat caccgcccgc
    14101 gcagcctccg acgccaccag caccgtcctg gcctcccacc tgcccgacct caccgaacgg
    14161 ctactcgcgg ccctggaacg ggacgaggcg ggcagtgaac tgctcgacgg ccgcaccggg
    14221 gccgccctcg ccctgcacgc cgcgatcacc ggcaccaccc cagccacccg ctgggacacc
    14281 tgcctcctgc tcgcctgaca ccgacacaag gggacacgac atgggcgccg gcctcgacat
    14341 cgacaccgga cccgacgaca ccggttgggc tcaggtggcc gtgcggatcg acgactacgc
    14401 cactgccgaa cacgttggca ccactcacct gggcccgctc atggcctccg ccgaacacgc
    14461 cgggctcatc acctgctggt ggttcgtccg gaagaacccg tactggcgac tgcgctggcg
    14521 accggtcccc ggcaccgcac acgaggcgaa ccatgtcgtc cagcgagcac tggacaccct
    14581 gcggggcaag ggaatcatcg ccgagacgac cgcgacgatc tacgaacccg agatccacgc
    14641 gttcggcggc gagaaggcca tggacctcgc ccaccgtctc ttccacgccg acagcacgca
    14701 cctgctcgac catctcgccg gtgaccgcgg ccgcggcccg agccctggtg agaagcggag
    14761 ggagctgacc gtgctgctgt gcagcaacct catgcgcgcc gccggacagg actggtacga
    14821 acaaggcgac atctgggccc gcgtcgccga caaccggccg ctgccagcca gcacctcggc
    14881 cgaccaggtc catgccgccg tggccggcct ccagcggctg atgaccgtcg acgccagccc
    14941 gaccagccca ctgctgcagc ccggcggctc cctggcccac gtcaccggct gggccaccgc
    15001 gttcgacaca gccggacagc atcttggccg tctggcccgc gccgggacgc tccgacgagg
    15061 cgtgcgggcc gtcctggccc accacgtgct cttccactgg aaccggctcg gcctgcccca
    15121 cgacacccaa gccctgatcg cgcacaccgc caagaccgtc gtcctcggca cgtgagcgcg
    15181 atcaggccag ccggtgccgg gcacgcgagc gcaactgcac ccaggactgg ttagggcagc
    15241 tcgatgaacg gcatcccgac agccaccagc ttggtctgca ggttgatgtc gctcgtcgcg
    15301 acgtacagca cggatcccgg atgtcggact gcagaagcaa gctggacgcc acgaaccggt
    15361 cgtccggcac ggtcaggtcg agccacgacg ggagacggtc gttgttgggt tcgacgtact
    15421 cgaacacggc acacacgtca cccgccaccc gccacccgcc acccggacgc cgacgctcgc
    15481 gtcgccgttc gtccgcaggc ccttgagccg cctctcggcg cgcttggcgg cctcgcgcag
    15541 gtcctgggtc ttgcctccgc gtttcaggtc gtcgagctcg cggagcacaa ccggcagcag
    15601 gcgcaccatg tacttgccgc cgggcgtggc cacgtgcacg gccaggtccg ggttgtcgat
    15661 cagcgtgttg gtgtcgaccg cgagccggac ggcgtactcg tcggcaggga aaaggtcggc
    15721 cagactgcga acatcagcca cagcctcacc gagcagctga gccgcctcct ccatcgtgga
    15781 cgggacatcg tgctcgccgg acttcctgac cagccacgac tccaagagct cggtgttctt
    15841 gtcgagccgc ttgctcatcg tcggagtcgg gtgcgggaac agcaggcgat accgcggccc
    15901 ccagtcgcgg actcggcgca gcaacgccat ccgatccgcc tcaagcgtct ccgaactcgg
    15961 tgcccaaccc cacatcgcga acccgatgaa caccatgccg ctgccgcgcc cgccgcggtt
    16021 cggatcgaca tcgacgatcg ccgacaccga gagcacgtcc gcgaaggcgg actcgatcgc
    16081 gtccagctcc gtcaggagac gccgcgcgta ggagtcagga acacgtcggc tcaccgatcc
    16141 agccacaaca gctcccctcg taacagaact ccggcgggaa acgagacaca tggctccgcg
    16201 acacaggctt ggcgcgcagc gaccaaaccc tcctgatcag gacacgaacc cttcctgaca
    16261 cggccggtgc ggcgacaagt ggcggcttcg gcagctgggc caccgcccag cgcgtcgccc
    16321 cctgccacgg caccgccaac atgatcttgc tgttcagtga cacgctgacc gaagaaacca
    16381 gcctctacgc gttcctcacc gagtccgccg cccaactcgg tgccccgctg gtgcgcgttg
    16441 cggacggccg gaccccgttc gaggtctact ggcactcccg gttcctgggc aattcccggc
    16501 tcgccccgtg ctcgaagatc ctcaagcagc agctggcccg tcgctggctg gaggtcaacg
    16561 gcgacccgcg cacggccacc ttgtacgtcg gcatcgacgc gggcgaaacc cgccgcatcc
    16621 ccggcgtccg cgccgggtgg gcgccgtgga ccgtgcagtt cccgctgacc gacgagccgg
    16681 aactgaccaa ggaggcgatg ctcgcagtgg ctcgtgggct cggcctgacc ccgcccgcgg
    16741 cctctcagaa gggcttcgcc cacgcgaact gcggcggcct gtgcgtgcgc ggcggccagg
    16801 cccactggcg gcgccggctc gtgcgccacc ccgacaggtt cgccgactac gaacaccgcg
    16861 agcaggagtt ccgcgccgag ttcggcgacg tcgcgatcct caaggaacag cgcgaccgcg
    16921 tggtgcgccc gctgccgctg accgagctgc gccgccgccc gcagccgacc tgtaccattg
    16981 cccgagctgc gccagcgaag gctggtacgc ggcttcactg gtgtgccggt actggcgagc
    17041 ctgctgtggc ctgtaccaag gttaccgcag ctacgtcgat cccgcctcgc ggaaccgcgt
    17101 tgactgcgcg gtctgccggg acgcctggac caccgcgtgg cgaggccgcg ccgaggcatg
    17161 cggcctgacc acgtccggtt ccgcctggtt gtcggccgcg tggacgcccg aagggcagca
    17221 gacccaccca ggacggtcaa ggccgtgccg ctgcgcggtc ggcttcgccg agccctgacc
    17281 gtcccgatcg gtcccgctgg gcgtgcgccc gtccacgcac caccagcacc caggaggcac
    17341 cgggtggccc ttcgttcccg agccctcgcc gtcgcggccg tcgccgcgtt ctccggcgtc
    17401 gccctgtcca gctgcggcct gcggtctccc aggcaggaac ccgccccgga tctgaccgtc
    17461 gccgacgtcc tgtacctcac cgagctgcgc cccgccgacg tcgagctgaa gacaccggac
    17521 gcatccgtcg actacacgcg tgccggccgg gacacctgcg cctcgctgga gaagagcaag
    17581 agcgttccgg ctgtggcgaa gcccctggcc agcagcttct acccggacga ggccagcgtg
    17641 atcatcgtgg ccgcgatcca caactactgc ccgcagcacg tcgggctcct ggctcttccc
    17701 ggccgcgcct gaccacctga atgagcgggg ctcgcgcgct tcccccagcg cggcccgctc
    17761 gaggcccggc cgggcgctgc caccctctgg cgcccggccg ggcctttcgt ccacccgccg
    17821 cactccctca accaggagga agacatggag gcttattcag gacgccgccc gccagcggtt
    17881 ggatgatcgc cagggtgggg taagcgaaat gagcggcggt ccgtttgaga gaatctggtt
    17941 ac
//
