LOCUS       NZ_RCDD01000006        22485 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Actinokineospora cianjurensis strain DSM 45657 Ga0180969_106, whole
            genome shotgun sequence.
ACCESSION   NZ_RCDD01000006
VERSION     NZ_RCDD01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora cianjurensis
  ORGANISM  Actinokineospora cianjurensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 308804)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 308804)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003663795.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:08:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,669
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,552
            CDSs (with protein)               :: 6,552
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 10 of 54
            Pseudo Genes (incomplete)         :: 50 of 54
            Pseudo Genes (internal stop)      :: 2 of 54
            Pseudo Genes (multiple problems)  :: 7 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 34381
            Orig. end                         :: 56866
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RCDD01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22485
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22485
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22485
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12485]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12485
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            281..2035
                     /locus_tag="CLV68_RS27365"
                     /old_locus_tag="CLV68_5535"
     CDS             281..2035
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (35-286). E-value:
                     4.3e-23. Score: 74.1. Matches aSDomain:
                     nrpspksdomains_CLV68_RS27365_Abhydrolase_1.1"
                     /NRPS_PKS="Domain: PKS_KR (323-480). E-value: 3e-10. Score:
                     32.3. Matches aSDomain:
                     nrpspksdomains_CLV68_RS27365_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683248.1"
                     /locus_tag="CLV68_RS27365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5535"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_121393793.1"
                     /sec_met_domain="PF00561 (E-value: 2.9e-17, bitscore: 57.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1e-14, bitscore:
                     49.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.8e-32, bitscore:
                     106.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASEPRHLPPTGPRRRTVGTDDVDLAVFSEGDPASPTILLVHGFP
                     DTHRLWDGLAERLVGDYHVVRYDVRGAGESTAPRKTAAYRTELLAEDLFAVADAVSPNR
                     PVHVVAHDWGSIQAWAAVTAPRAKTRIASFTSVSGPHLDHIGQWTRRRLTHPTPANLVQ
                     VATQLAHSWYIAAFHLPVLPALAWRTVIGPRWGGILRRVEGVDSTPAPTIGTDAANGVR
                     LYRANMLTSAAKPAPGPTEVPVQVVLPTRDRFVTAALAEDLERWVPRLWRRRIVAGHWV
                     PLSHPEALARMVEDFVEHVSGAPMTRSLQRARAGRAEGFTNRLVVVTGAGKGIGRATAH
                     AFAARGAEVVVADVDIEAARRTAAEIGPAAYPYLVDVSDADAVRAFAEDITDQHGTPDV
                     VVNNAGIGMAGPFLATTARDWQRITDVNLLGVVNGCREFGALMAEAGEGGHIVNISSAA
                     AYTPSRSLSAYAASKAAVLALSDCVRAEFVDHGIGVTAVCPGVVATDITNTTTFTGADD
                     LEQQRMRQKATKAYARRGFTPDRVAEEIVRAVDHGTPVVAVTPEAKLARFGSRFAPGLM
                     RRVARLIG"
     aSDomain        386..1138
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV68_RS27365_Abhydrolase_1.1"
                     /evalue="4.30E-23"
                     /label="CLV68_RS27365_Abhydrolase_1.1"
                     /locus_tag="CLV68_RS27365"
                     /protein_end="286"
                     /protein_start="35"
                     /score="74.1"
                     /tool="antismash"
                     /translation="PTILLVHGFPDTHRLWDGLAERLVGDYHVVRYDVRGAGESTAPRK
                     TAAYRTELLAEDLFAVADAVSPNRPVHVVAHDWGSIQAWAAVTAPRAKTRIASFTSVSG
                     PHLDHIGQWTRRRLTHPTPANLVQVATQLAHSWYIAAFHLPVLPALAWRTVIGPRWGGI
                     LRRVEGVDSTPAPTIGTDAANGVRLYRANMLTSAAKPAPGPTEVPVQVVLPTRDRFVTA
                     ALAEDLERWVPRLWRRRIVAGHWVPLSHP"
     aSDomain        1250..1720
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV68_RS27365_PKS_KR.1"
                     /evalue="3.00E-10"
                     /label="CLV68_RS27365_PKS_KR.1"
                     /locus_tag="CLV68_RS27365"
                     /protein_end="480"
                     /protein_start="323"
                     /score="32.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVVVTGAGKGIGRATAHAFAARGAEVVVADVDIEAARRTAAEIGP
                     AAYPYLVDVSDADAVRAFAEDITDQHGTPDVVVNNAGIGMAGPFLATTARDWQRITDVN
                     LLGVVNGCREFGALMAEAGEGGHIVNISSAAAYTPSRSLSAYAASKAAVLALS"
     CDS_motif       1256..1333
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV68_RS27365_0001"
                     /evalue="1.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="CLV68_RS27365"
                     /protein_end="351"
                     /protein_start="325"
                     /score="14.7"
                     /tool="antismash"
                     /translation="VVTGAGKGIGRATAHAFAARGAEVVV"
     misc_feature    1709..1711
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2040..2426)
                     /locus_tag="CLV68_RS27370"
                     /old_locus_tag="CLV68_5536"
     CDS             complement(2040..2426)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS27370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5536"
                     /product="hypothetical protein"
                     /protein_id="WP_121393794.1"
                     /transl_table=11
                     /translation="MRALMSWLMCLVGVAVVAFGAFRAWYEDRVGTTLPLSDLFSGVTR
                     ESAPVLGSLTLPLAIGALLAVVGMFRAKGILQLGGIILAATMVVWVVRAREVVDLGDLQ
                     VGAWNALFGSLLVLAAGILRPGRL"
     gene            complement(2501..3310)
                     /locus_tag="CLV68_RS27375"
                     /old_locus_tag="CLV68_5537"
     CDS             complement(2501..3310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007025348.1"
                     /locus_tag="CLV68_RS27375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5537"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_121393795.1"
                     /transl_table=11
                     /translation="MRSTSNPAFRNLPQGGYAGFQPQAQGYQHQGYPPGYGSPSAPAGT
                     GDRPMTVDDVVTKTAVTLGVAVVVGVITAVLVLGKDLSPYPPMIIGALVGLVISLVIIF
                     KKTPSPALVLTYSAAEGLFLGAITGVFEMFVPGIAFQAILGTALVFITMLVVYKTGAVK
                     VTPKLTKWIIGATVGAAGLMLVNLVLSMFGVNMGIRDAGPLGIGISLLFIGIAAFNFLL
                     DFDMADQMIRSGTPSKFAWYVAFGLMTTLVWLYLEILRLLYMLQSSD"
     gene            3728..5200
                     /locus_tag="CLV68_RS27380"
                     /old_locus_tag="CLV68_5538"
     CDS             3728..5200
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006239309.1"
                     /locus_tag="CLV68_RS27380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5538"
                     /product="prealbumin-like fold domain-containing protein"
                     /protein_id="WP_211346790.1"
                     /transl_table=11
                     /translation="MRRSTLGARLTSAVATVATLSAALLVVGASPAAADYQKGLGVGVA
                     PQPYRGAPPTSTEDWLGSYVVGGKQVWCVKFAFKEPDTNEVYQPGDVLKTKYGDALSPT
                     QAADISYLLLRYAETKDATEAAALAHLLHQWTAAPRSPADLNPATNGFRTIAYDIAFHD
                     RELAQKAPAVVQAVGRLRADATANHGPWTTALTKPTKPQVIGTADTWTAEVRGAGGSGV
                     GKVPVKVVLTDATSGGKTELTATTKDNGGPIALEVVPTGPKPSVSISLLAPADQPVVQH
                     TVKDGTQSVVSTGGEKQLKAAADTTAVTAPGAVSVAKVDEKTGQGIASVSLKVTGADKT
                     TPAVGQDGKPLVGADGKPLVVVTGADGKAAVPNLRTPQEVCVTEVAAPPGYEQSFDPAK
                     PPSACGKLEPGKTLELRLVNKPNVPTVPQTIPAGDGPTNAAAVVDESGPSVGLLVALGA
                     LLLFAGGAGTALWRKGRGPVVVGRRMRKDWGH"
     misc_feature    3797..3799
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5207..5971
                     /locus_tag="CLV68_RS27385"
                     /old_locus_tag="CLV68_5539"
     CDS             5207..5971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683244.1"
                     /locus_tag="CLV68_RS27385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5539"
                     /product="class F sortase"
                     /protein_id="WP_121393796.1"
                     /transl_table=11
                     /translation="MARRSSTLAPPAVAGGAGVLVLLVCGLTFASPTPVQGLPLPAQPG
                     LQLTAIRKAAADSDAALAGLRSQIKPKPAEPTTTAPARPPQPTATQPPTQAQPAPPAPP
                     RQAAGQRPGTLRLAKGGTATLVRKELGPDATLPVPSGVREATWWGAGLDAPAGASVFAG
                     HVNWKGATGPFAELWSSRVGDLVSVVDDKGTQWRYRVTQVETVGKHDLPARAEEFFGQT
                     GPHRVVLVTCGGQWVGGADGYESNRVVVAVPA"
     gene            6086..7213
                     /locus_tag="CLV68_RS27390"
                     /old_locus_tag="CLV68_5540"
     CDS             6086..7213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683243.1"
                     /locus_tag="CLV68_RS27390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5540"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_121393797.1"
                     /transl_table=11
                     /translation="MSTRRRWEFIVVGAAVVLAFVVLVFVGTVRPQQHGQVREPEPHPQ
                     ASAGPPKWMRKLNPGEKPPQFVLFSFDGAGSHEHWQKFLPLARSVNAHFSGFLSGIYML
                     TDAQKAEYTGPGHKPGRASIGFGGSAEDVRALIGDLNTAVDQGNEVGTHYNGHFCHGSE
                     PSVGRWDTAQWNSELDQFFAFVDRGRAMGLKVDPKTIKGGRTPCLEGDFDVLLPVLARR
                     GMTYDTSQVSDGLAWPTTQHGVWEFAMPSVRVPGLKYKKTIMMDYNLWYLLNKAKDEPA
                     RAAEFTGVVFDTYERAYQAAFDGNRAPVVVGNHFNTWSGGAFTAATEKFMGSVCAKPET
                     VCATYSEVVEWLGLQDPAVLDAFRKMPNAQIAQPS"
     misc_feature    7239..7252
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.78"
                     /tool="antismash"
     misc_feature    complement(7242..7257)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    7245..7260
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.53"
                     /tool="antismash"
     gene            7304..8263
                     /locus_tag="CLV68_RS27395"
                     /old_locus_tag="CLV68_5541"
     CDS             7304..8263
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073109.1"
                     /locus_tag="CLV68_RS27395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5541"
                     /product="ATP-binding protein"
                     /protein_id="WP_121393798.1"
                     /transl_table=11
                     /translation="MKIAFVGKGGSGKTTLASLFLRHLAAETPAPPLLGIDADINQHLA
                     AALGAGDDHQQPTLGEHMSVIKDHLRGDNPRVHSAGDMIKTTPPGRGSRLIGIDDDNPL
                     YTRFVRVVDGVRLAATGPFTESDLGVSCYHSKVGAVELLLNHMVDGAGEYAVVDMTAGA
                     DSFASGLFTRFDVTFLVCEPTLRSVGVYRQYLDYARDFDVRVAVVGNKVIDADDVAFLR
                     QHVGADLLTWIGRSDHVRAAERGDIRPVEQLEPANRDALRSMRALVDGVEQDWPKFHRQ
                     TVEFHLRNATAWANGRAGRDLADQVDPGFVPGPVSLAG"
     gene            8403..9275
                     /locus_tag="CLV68_RS27400"
                     /old_locus_tag="CLV68_5542"
     CDS             8403..9275
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS27400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5542"
                     /product="DivIVA domain-containing protein"
                     /protein_id="WP_170224618.1"
                     /transl_table=11
                     /translation="MGPQQDHPEFGVSRHGYDRTQVKRYLGTLAEQHAATTAERDEARA
                     RTEELDGQLQLARREIAALTERLDKIGNAAAASSAPNAAERAARAVATAEAQAAEITAR
                     AEAAADTAWSAAEAASTALRDRYRALMADVEKRHTELHEAHEQLMSDTRAKVEDMTTAA
                     TARQRTTDDQAERDRQRVEQQFQQELTTRRTDLDTEITTARATATAEATRVVQTATDEA
                     AKRIATATSQVERLTALREQLAGRLRGTSELLTQSTHLLEPLAAESEMDELAANAPTAK
                     NLPIPQKTS"
     gene            complement(10001..11011)
                     /locus_tag="CLV68_RS35805"
                     /old_locus_tag="CLV68_5543"
     CDS             complement(10001..11011)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644035.1"
                     /locus_tag="CLV68_RS35805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5543"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_121393800.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.3e-57, bitscore:
                     187.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPGIEQLLAESRTAVLPALRAAVDSLPPAMRRIACYHFGWLDVC
                     GLPVSGDSGKMVRSALTLLSAQAVGGDPVDAVPAAVAIELVHNFSLLHDDIMDGDRTRR
                     HRGTAWAVFGVPTALLAGDALWALALRVLAAGPHADRALPQLTEALWRLMDGQSADADF
                     PHRRTVTVAECEAMAAGKTGAVMACATALGALFGGASAHRVALLRDMGEHLGMAFQLVD
                     DVLGIWGDPETMGKPGADLVHRKKSLPVVAALNSGTVAGAELAAVYLDVEGELSSAEQV
                     RVAGLISSAGGREWALSEAERHLALAAAALAEASPVGVAAESLGVLADHLAHRER"
     misc_feature    complement(11147..11161)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
     misc_feature    11148..11162
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
     misc_feature    11168..11182
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.89"
                     /tool="antismash"
     misc_feature    complement(11378..11393)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    11386..11399
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.84"
                     /tool="antismash"
     misc_feature    complement(11407..11420)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.12"
                     /tool="antismash"
     gene            11412..12485
                     /locus_tag="CLV68_RS27410"
                     /old_locus_tag="CLV68_5544"
     CDS             11412..12485
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="CLV68_RS27410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5544"
                     /product="terpene synthase family protein"
                     /protein_id="WP_147460184.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-45, bitscore: 151.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNSPHPGAGLRYGMTYRLPALPTRCPLAVHPDAAATAPRVEAWL
                     RPYLVDYFGESEQDSPVTGHYLRQDLHRWGALCMPHTRSDRFFTQQLWMNAAALLDDAF
                     SAPWLREQSARDRLARQLCAAVEGTPGGATPLARLLGDVHAMLLPTAGALRERLVQVGT
                     SVVVDNANQHDIGEFDDLDAYLGSSRRVNAYGYWILTLAEWALGVDLGGLVDEDPLVRK
                     ACALAIDHWILVNDLYSFAKEIEEGEKINAVWVLLGQGAPLQEALDAIAARAVATEERF
                     IATRDKISRGPLRRRDDLARFLAEVGHMITGNLRHARESSRYHGDGHRVADDLAGNPVA
                     EQRTLVRLGTVHQPLAD"
     gene            complement(12482..12964)
                     /locus_tag="CLV68_RS27415"
                     /old_locus_tag="CLV68_5545"
     CDS             complement(12482..12964)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950488.1"
                     /locus_tag="CLV68_RS27415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5545"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_170224619.1"
                     /transl_table=11
                     /translation="MTTEESPGIDVLDARLLLLLTDEPRLGVLECSRRLGVARGTVQAR
                     MDRLERRGVLTGFPPAVDLAAMGYGLTAFAVLEIAQGKRGEVATRLHAIPEVCEVHATT
                     GEGDLLVRMVAQNNADLQRVIDRVVNVEWVRRTSTSIALSTPIPTRVRPLLEREVR"
     misc_feature    12926..12940
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    complement(13038..13054)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.63"
                     /tool="antismash"
     gene            13116..14318
                     /gene="hppD"
                     /locus_tag="CLV68_RS27420"
                     /old_locus_tag="CLV68_5546"
     CDS             13116..14318
                     /EC_number="1.13.11.27"
                     /GO_function="GO:0003868 - 4-hydroxyphenylpyruvate
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0006559 - L-phenylalanine catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006572 - tyrosine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hppD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950489.1"
                     /locus_tag="CLV68_RS27420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5546"
                     /product="4-hydroxyphenylpyruvate dioxygenase"
                     /protein_id="WP_092779865.1"
                     /transl_table=11
                     /translation="MTGTLNRGDQGMDEVSFDQLRQLVGLVEYDESKDPFPVRAMDAVV
                     FVVGNATQTALFYQAAFGMTQVAYSGPETGNRDHKSYVLKSGSARFVIKGGVDPKSPLL
                     DHQRAHGDGVVDLALEVTDVDKCLAHARAQGAIVLEEAHDVTDEHGTIRVGAIATYGKT
                     RHSLIDRSRYNGVYLPGYVEKAGAYKKPEGAPKRIFQAVDHCVGNVELGKMDYWVDWYN
                     RVMGFVNMAEFVGDDIATEYSALMSKVVANGNHRVKFPLNEPAIAKKKSQIDEYLEFYG
                     GPGCQHIALATNDIIATVTAMRAAGVEFLDVPDSYYEDPELRERIGNVRVPIEQLKEHA
                     ILVDRDEDGYLLQIFTKPTGDRPTVFYEMIERHGSLGFGKGNFKALFEAIEREQDRRGN
                     L"
     gene            14445..14696
                     /locus_tag="CLV68_RS27425"
                     /old_locus_tag="CLV68_5547"
     CDS             14445..14696
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013673132.1"
                     /locus_tag="CLV68_RS27425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5547"
                     /product="hypothetical protein"
                     /protein_id="WP_143073539.1"
                     /transl_table=11
                     /translation="MATSRRAMPLAGAAAAALVLAGVAVFTVSNAGCASAGEFVQRGQG
                     LELVGGCVDPADLPPASSTPTVGTNPGSAVERFHQVSP"
     gene            complement(14767..15924)
                     /locus_tag="CLV68_RS27430"
                     /old_locus_tag="CLV68_5548"
     CDS             complement(14767..15924)
                     /EC_number="2.5.1.48"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466185.1"
                     /locus_tag="CLV68_RS27430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5548"
                     /product="cystathionine gamma-synthase"
                     /protein_id="WP_121393802.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.4e-12,
                     bitscore: 41.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADETSRWGFETRAIHAGQEPDPRTGSVIVPIYATSTFAQDGVGG
                     VREGGYEYSRSANPTRTALEQALAALEGGKHGLAFASGLAASDVALRSMTRPGDHVILG
                     NDAYGGTFRLLDKVLTQWGVEYTSVDLSDLTATRAALRPTTKVIWSETPTNPLLGIADI
                     AALAAVAAEGGAKLVIDNTFATPYLQSPLGLGADVVLHSTTKYLGGHSDVVGGALITSD
                     DDLRDKFAFLRNAAGAVPSPFDAWLVLRGAKTLALRMERHSDNAERIVEALLNHPKVTK
                     VYYPGLPEHPGHEVAAKQMRRFGGMVSFSVAGGEEAALAVAARTKLFILAESLGGIESL
                     IEHPGKMTHASTTGSPLQIAGDILRLSVGIEDGTDLVNDLLKALD"
     misc_feature    15919..15929
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(15964..15978)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.21"
                     /tool="antismash"
     misc_feature    15965..15979
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.93"
                     /tool="antismash"
     misc_feature    15973..15987
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            complement(16074..16592)
                     /locus_tag="CLV68_RS27435"
                     /old_locus_tag="CLV68_5549"
     CDS             complement(16074..16592)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS27435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_5549"
                     /product="hypothetical protein"
                     /protein_id="WP_121393803.1"
                     /transl_table=11
                     /translation="MNYQAPYQQQGYYPQFQQAAPGSPATAVVAGLGALGIAAGIGGSS
                     AYFVAEVPYASDVFELPAGLQSLVIGRLVLAALALIGAVMLFARRRAGVPVVAITAVLG
                     VASLPLEPFVSELLRGIGLGIGDYFQALTEFNDTYTILLAVGAIAGILAFFFAVLPSTG
                     RWLRGAARY"
     gene            complement(16681..17949)
                     /locus_tag="CLV68_RS27440"
                     /old_locus_tag="CLV68_5550"
     CDS             complement(16681..17949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156023.1"
                     /locus_tag="CLV68_RS27440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5550"
                     /product="hypothetical protein"
                     /protein_id="WP_121393804.1"
                     /transl_table=11
                     /translation="MSAPQPPNQPWQGGQPQQWPGQPGQDQPPYGQQPGGYPPPQPHYA
                     PPPGDTTGADGVERTQAIRPGQTPPGGEEEGVDRTQVVRPGQGDATQMVPPGSVSQSPP
                     YAPPPSAADQASPPGGFHQPYGQQQPPQQQYGQPGGFGQQQQGYGQQQPGGYPGQPGGF
                     AQQSGLGGAPGAGGQGQNTGMIALIVLGAVAVLGLIALIMSISLMSNISTISGLCGDVR
                     GLGGVASSYCPSGFNTFLSFVQIAGAAVAIAGAVLLALKKNLNIAHLLVAGGGGGLVVA
                     AILNGATFSFVGQIMTPLVFGLLIAGAGALAFFPQTKDYLLGSSPLSSLSSGSGGPGAG
                     GPGGFGQPHQQQGFGQQQPPQQYGQPGGFGQQQPPQQQYGQPPQGQQPGFPPPQQGYGQ
                     QPPPPPPGGFGQQPPGGQPPQQW"
     gene            complement(18069..19448)
                     /locus_tag="CLV68_RS27445"
                     /old_locus_tag="CLV68_5551"
     CDS             complement(18069..19448)
                     /EC_number="4.2.1.22"
                     /GO_function="GO:0004122 - cystathionine beta-synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019344 - cysteine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229841.1"
                     /locus_tag="CLV68_RS27445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5551"
                     /product="cystathionine beta-synthase"
                     /protein_id="WP_121394019.1"
                     /sec_met_domain="PALP (E-value: 1.2e-70, bitscore: 232.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVEHIFDLVGDTPLVRLNTLADGLAPTVLAKVEYFNPGGSVKD
                     RIALRMVEAAEASGELRPGGTIVEPTSGNTGVGLAMVAQRKGYKCVFVCPDKVSEDKRN
                     VLKAYGAEVVVCPTAVAPEHPDSYYNVSDRLVREIEGAWKPNQYANRENPASHYHSTGP
                     ELWRQTEGKITHFVAGVGTGGTISGTGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYL
                     VEGVGEDFWPETYDRSVADEIIAVSDSESFEVTRRLAREEAMLVGGSCGMAAAAALRLA
                     KRLGPDDVVVVLLPDGGRGYLSKVFNDSWMAQYGFLPPEHSGATVGDVLRRKSASGTTI
                     PDFVHAHPTETVADAVAILREFGVSQMPVVNAEPPVMAAEVVGAVNERDLLDALFTGKA
                     ALADRLDRHMSGPLPTIGAGEQVSVAMTALTDADGALVLVDGKPAGVVTRQDLLGFLAG
                     R"
     gene            19616..20428
                     /locus_tag="CLV68_RS27450"
                     /old_locus_tag="CLV68_5552"
     CDS             19616..20428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683239.1"
                     /locus_tag="CLV68_RS27450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5552"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_121393805.1"
                     /transl_table=11
                     /translation="MLWIRGLWVAAVAAGSVGGLSGAAYTLLQSQSRQARSIIGVPRDL
                     PFNADGCYWPDGTGPGQVADALTFGIFGDSTAAGLGAESPEALPGVQLARGLAEESGRP
                     VRLTTYAVVGSRSTHLADQVDRALLDPPRAAVVMVGGNDVTARLGVAACAELLGEQVRR
                     LVAAGTGVVVGTCPDLGTVRPIPQPLRSLAQRWSLALGRAQARALVGSGAAVVPMTLVS
                     RHFARRPDELFSPDRFHPNGAGYGLAAGVILAPLCAVAGVCHSAVTPG"
     misc_feature    20000..20002
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20514..21734
                     /locus_tag="CLV68_RS27455"
                     /old_locus_tag="CLV68_5553"
     CDS             20514..21734
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="CLV68_RS27455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5553"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_121393806.1"
                     /transl_table=11
                     /translation="MPEAVIVSAVRSPIGRAGKGSLVDIRPDDLTAQMVRAALDRVPAL
                     DPTDIDDLMLGCGLPGGEQGNNIGRIVSVLLGYDFLPGCTVTRYCASSLQTTRMALHAI
                     KAGEGEVFISAGVETVSRFAKGSSDSWPDTHNPIFAEAEARTAAVAESGADEWHDPRLD
                     GRVPNAYLAMGQTAENLALAKGITREEMDHFGVRSQNRAEQAIKDGFWAREITPVTLPD
                     GRVVETDDGPRAGVNYEKTATLQPVFRPDGRVTAGNCCPLNDGAAALVIMSDRKAAELG
                     LTPLARIVATGVSGLSPEIMGRGPVEASRRALAIAGLSISDIDLVEINEAFAAQVIPSA
                     RELGVDDDKLNVNGGAIAVGHPFGMTGARIATTLINSLQWHDKQFGLETMCVGGGQGMA
                     MVLERLS"
     gene            complement(21923..22417)
                     /gene="greA"
                     /locus_tag="CLV68_RS27460"
                     /old_locus_tag="CLV68_5554"
     CDS             complement(21923..22417)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0070063 - RNA polymerase binding [Evidence
                     IEA]"
                     /GO_process="GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /gene="greA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466179.1"
                     /locus_tag="CLV68_RS27460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_5554"
                     /product="transcription elongation factor GreA"
                     /protein_id="WP_092780077.1"
                     /transl_table=11
                     /translation="MTVSDTQVTWLTQEAYNRLKNELDELIENRPVIAQKINTSREEGD
                     LKENGGYHAAREEQGQQEARIRHLQELLRGAKVGEAPANDGIAEPGMVLTVRYDGDDDE
                     EVFLLATREEGGEGELEVYSPESPLGRALLGAKEGETREYDLPNGKTQKVTLTKAVPYG
                     G"
ORIGIN
        1 tccgcaggta cgtgctcgac cccaagggcc cggactggct gcccagcggc gacgagctgc
       61 cgcacttcgc cgacgtcatc tcccggctgc acccgctggt gatgtccgcg gtcggcgccg
      121 cggtcgaccg gtcggcgagc cgggtcatcc ccgaggtcat cggcgaccgg ttgatcgccc
      181 tggccgagcg ggccaggggc cgggcggaat gacacccttg cagcgtgaca acggcgattg
      241 taacgttcgc cattgtcaag aacccgggtg aggagccgcc atggccagcg aaccgcgcca
      301 cctgcccccc accgggcccc gccgccgcac cgtcggcacc gacgacgtcg acctggccgt
      361 cttcagcgag ggcgacccgg cgtcgcccac gatcctgctg gtgcacggct tccccgacac
      421 ccaccgcctc tgggacggcc tggccgaacg cctggtgggc gactaccacg tcgtccgcta
      481 cgacgtgcgc ggcgctggcg agtcgaccgc cccgcgcaag accgccgcgt accggaccga
      541 gttgctggcc gaggacctgt tcgccgtcgc cgacgcggtc agcccgaacc gcccggtgca
      601 cgtcgtcgcg cacgactggg gttccatcca ggcgtgggcc gcggtcaccg cgccgcgcgc
      661 caagaccagg atcgcgtcgt tcacctcggt ctccgggcct cacctcgacc acatcggcca
      721 gtggacccgc cgcaggctca cccaccccac cccggccaac ctggtgcagg tcgccaccca
      781 gctcgcgcac tcctggtaca tcgccgcgtt ccacctcccc gtgctgcccg ccctcgcctg
      841 gcgcaccgtg atcggccccc gctggggcgg catcctgcgc cgggtcgagg gtgtcgactc
      901 gacccccgcg ccgacgatcg gcaccgacgc ggccaacggc gtgcgcctct accgcgcgaa
      961 catgctcacc agcgctgcca agcccgcgcc cggcccgacc gaggtgcccg tccaggtcgt
     1021 gctccccacg cgggacaggt tcgtcaccgc ggcactcgcc gaggacctgg agcgctgggt
     1081 cccccggctg tggcggcgcc ggatcgtcgc cgggcactgg gttccgctgt cgcacccgga
     1141 agccctggcg cgcatggtcg aggacttcgt ggagcacgtc tccggcgccc cgatgacgcg
     1201 cagcctgcaa cgggcccgcg cgggccgtgc agagggtttc accaaccggc tcgtggtggt
     1261 gacgggcgcg ggcaagggca tcggtagggc taccgcgcac gcgtttgcgg ctagaggagc
     1321 cgaagttgtg gtcgccgacg tcgacatcga ggccgcgcgt cgcactgctg cggagatcgg
     1381 accggccgct tacccgtacc tggtcgatgt gtctgacgcc gacgccgtgc gcgcgttcgc
     1441 cgaggacatc accgaccagc acggcacccc cgacgtcgtg gtcaacaacg ccgggatcgg
     1501 catggcgggc ccgttcctgg ccacgaccgc gcgcgactgg cagcggatca ccgacgtcaa
     1561 cctgctcggc gtcgtcaacg gctgccgcga gttcggcgcg ctgatggccg aggcggggga
     1621 gggcggccac atcgtcaaca tctcctcggc cgccgcatac acccctagcc gctccctctc
     1681 cgcttacgcg gcaagcaaag cagcggtgtt agcgctatcg gactgcgttc gcgctgagtt
     1741 cgtcgaccac ggcatcggtg tcacggcagt ctgtcccggt gttgtggcta ccgacatcac
     1801 gaacacgacc acgttcaccg gcgccgacga cctggagcag caacggatgc ggcagaaggc
     1861 gacaaaggct tacgcgcgcc gcggattcac cccggaccgg gtcgccgagg agatcgtccg
     1921 cgccgtcgac cacggcaccc cggtcgtcgc cgtcaccccg gaggccaagt tggcccgctt
     1981 cgggtcccgg ttcgcccccg gcttgatgcg ccgcgtcgcc aggctgatcg gctgatccct
     2041 cagagcctgc ccggccgaag gatccccgcc gccaacacca acaggctgcc gaacagcgcg
     2101 ttccaggcgc ccacctgaag atcacccagg tcgaccactt cgcgcgcccg caccacccac
     2161 acgaccatgg tcgcggccag gatgatcccg cccaactgca ggatcccctt ggcgcggaac
     2221 atccccacca ccgcgagcaa cgccccgatc gccagcggca gggtcaacga ccccagcacc
     2281 ggcgcgctct ccctggtgac cccgctgaac aggtccgaca acggcagcgt ggtgcccacc
     2341 cggtcctcgt accacgcccg gaacgcgccg aaggcgacca cggccacccc gaccaggcac
     2401 atcagccacg acatcagtgc gcgcacgaga tcgactctaa ggccaaacaa gaggggcgcc
     2461 caaccggccg gttgggcgcc cctgtcgtgc tggcgggtga tcagtcgctg ctctgcagca
     2521 tgtagagcag gcgcaggatc tccaggtaca gccagaccag ggtggtcatc aggccgaagg
     2581 cgacgtacca ggcgaacttc gacggggtgc cggagcggat catctggtcg gccatgtcga
     2641 agtcgagcag gaagttgaac gcggcgatgc cgatgaacag caggctgatg ccgatgccca
     2701 gcggtccggc gtcgcggatg cccatgttca cgccgaacat cgacagcacc aggttgacca
     2761 gcatcagacc ggcggcgccg acggtggccc cgatgatcca cttggtcagc ttcggggtga
     2821 ccttgaccgc gccggtcttg tagaccacca gcatcgtgat gaacaccagc gccgtgccca
     2881 ggatggcctg gaacgcgata ccggggacga acatctcgaa aacgccggtg atggcaccga
     2941 ggaacaggcc ctcggcagcg gagtaggtca gcacgagcgc ggggctcggg gtcttcttga
     3001 agatgatgac gagcgagatg accaggccga cgagcgcgcc gatgatcatc ggcgggtacg
     3061 ggctgaggtc cttgccgagc acgagcaccg cggtgatgac gcccaccacg acggcgacgc
     3121 cgagggtgac cgcggtcttg gtgaccacgt cgtcgacggt catcgggcgg tcgccggtgc
     3181 ccgctggcgc gctggggctg ccgtacccgg gcgggtagcc ctggtgctgg tagccctggg
     3241 cctggggctg gaagcccgcg taaccgccct gcggcaggtt gcggaacgcg gggttgctgg
     3301 tagaacgcac ctgatcctcc tgggcctgga tggcgcctgc tgacggtcaa cgatcgaccc
     3361 ggccgaccgg ttcccgctgg gtaaaaccca ctttacccac attcggcgca acgcagggca
     3421 ggcaccgccg attcccgcac ggcacaccga gcgtgaccgt ccaggcgcac actacgccgt
     3481 ccggtacccc acatgccgcc cgacctcggc gccgacctgc gggaacgccg cagggtaacc
     3541 atgatcaact ccactgggtt ggcggattgc ccggtgcccc gcccacccag caggctcgca
     3601 cggaaggtgc gcgccccggt ccccatccgc tctcccccgc ggcgggccgc accgccagag
     3661 cagttccccg cacttcaagc gccgacggcc gtgcgctgcc ccggcgcggc aaggagccga
     3721 ccgaaccatg cggcgatcca cactcggtgc ccggctgacc tctgcggtgg cgacggtggc
     3781 caccctgtcg gcggcgttac tcgtcgtcgg cgcctcaccg gccgcagccg actaccagaa
     3841 gggcctcggt gtcggggtgg ccccccagcc gtaccggggc gcgccgccca cctcgacgga
     3901 ggactggctc gggtcctacg tcgtcggcgg caagcaggtc tggtgcgtca agttcgcctt
     3961 caaggaaccc gacaccaacg aggtctacca accgggcgac gtgctcaaga ccaagtacgg
     4021 cgacgccctg tccccgaccc aggccgcgga catctcctac ctgctgctgc gctacgccga
     4081 gaccaaggac gccaccgagg ccgccgccct ggcgcacctg ctgcaccagt ggaccgcggc
     4141 cccgcgcagc ccggccgacc tgaacccggc gaccaacggg ttccgcacca tcgcctacga
     4201 catcgccttc cacgaccgcg aactcgccca gaaggccccg gccgtggtgc aggccgtcgg
     4261 caggctgcgg gccgacgcca ccgccaacca cggcccgtgg acgacggcgc tgaccaagcc
     4321 gaccaagccg caggtcatcg gcaccgcgga cacctggacc gccgaggtgc gcggcgcggg
     4381 cggcagcggc gtcggcaagg tcccggtcaa ggtcgtgctg accgacgcga cctccggcgg
     4441 caagaccgag ctgaccgcga ccaccaagga caacggcgga cccatcgcgc tggaggtcgt
     4501 gccgaccggg ccgaagccgt cggtgtcgat ctcccttctc gcgcctgccg accagccggt
     4561 cgtgcagcac acggtcaagg acggcaccca gagcgtcgtg tccaccggcg gtgagaagca
     4621 gctcaaggcg gcagccgaca ccaccgccgt caccgcgccc ggcgccgtct cggtggccaa
     4681 ggtcgacgag aagaccgggc agggcatcgc ctcggtgtcg ttgaaggtca ccggcgccga
     4741 caagaccacc ccggccgtcg gccaggacgg caagcccctc gtcggcgcgg acggcaagcc
     4801 gctggtcgtg gtgaccggcg cggacggcaa ggcagcggtg ccgaacctgc gcaccccgca
     4861 ggaggtctgc gtcaccgagg tcgccgcgcc gcccggctac gagcagtcct tcgacccggc
     4921 caagccgccg tcggcgtgcg ggaagctcga accgggcaag acgctggaac tgcggctggt
     4981 caacaagccc aacgtgccga ccgtcccgca gaccatcccc gcgggcgacg gtccgaccaa
     5041 cgccgcggcc gtggtcgacg agtccggccc gtccgtcggc ctgctcgtcg ccctcggcgc
     5101 gctgctgctg ttcgcgggcg gcgcgggtac cgccctgtgg cgcaagggcc gcggtccggt
     5161 cgtggtcggg cgccgcatgc gcaaggactg ggggcactga cccggcatgg ctcgccgtag
     5221 ctcgacgctc gccccacccg ccgtcgcggg tggggcgggc gtgctcgtgc tcctggtctg
     5281 cgggctgacc ttcgcctcgc cgacaccggt gcagggcctc ccgctgcccg cccagccggg
     5341 cctgcagctc accgccatcc gcaaggccgc cgccgacagc gacgccgccc tggccgggct
     5401 gcggtcgcag atcaagccga aacccgccga accgaccacg accgcaccag cgcgaccgcc
     5461 gcagccgacc gccacccagc cacccaccca ggcccagccc gccccgcccg caccgccgcg
     5521 ccaggccgcc gggcagcgcc ccggcacgct ccggctcgcc aagggcggca ccgcgaccct
     5581 ggtgcgcaag gaactgggcc cggacgccac gctgccggtc ccgagcgggg tcagggaggc
     5641 cacctggtgg ggcgccggtc tcgacgcccc agcgggcgcg tcggtgttcg ccgggcacgt
     5701 caactggaag ggcgccaccg ggccgttcgc cgagctgtgg agctcccggg tcggcgacct
     5761 cgtctcggtc gtcgacgaca agggcaccca gtggcgctac cgggtgaccc aggtggagac
     5821 ggtcggcaag cacgacctgc cagccagggc cgaggagttc ttcgggcaga ccgggccgca
     5881 ccgggtcgtc ctcgtcacct gcggcggcca gtgggtcggc ggggcggacg gctacgagtc
     5941 gaaccgggtg gtcgtcgccg tcccggcctg agccacccgc gcgggccacg tccgggggac
     6001 accgggtggc aacgcgtcat cggcacgcgc gtcccttctc aggggaagcg gcaattcggg
     6061 gagcggtggc aggggaggga cgcgaatgtc gaccaggagg cgttgggagt tcatcgtcgt
     6121 cggggcggcg gtggtcctgg cattcgtcgt cctcgtcttc gtcggcaccg tccgaccgca
     6181 acagcacggg caggtgcgcg aaccggaacc gcacccgcag gcatccgccg gaccgccgaa
     6241 gtggatgcgg aagctgaacc cgggcgagaa accgccgcag ttcgtgctgt tctcgttcga
     6301 cggcgccgga tcgcacgagc actggcagaa gttcttgcca cttgccagaa gcgtgaacgc
     6361 gcatttctcc gggttcctgt ccgggatcta catgctgacc gacgcgcaga aggcggagta
     6421 caccggaccc ggccacaaac ccggtcgcgc gtcgatcgga ttcggcggat cggccgagga
     6481 cgtgcgcgcg ttgatcggcg acctcaacac cgccgtcgac cagggcaacg aggtcggcac
     6541 ccactacaac gggcacttct gccacgggtc cgagcccagc gtcggccggt gggacaccgc
     6601 gcagtggaac tccgagctgg accagttctt cgcgttcgtc gaccgcggta gagcgatggg
     6661 cctcaaggtc gacccgaaga ccatcaaggg cggccggaca ccgtgcctgg agggcgactt
     6721 cgacgtgctg ctgccggttc tggcgcggcg cggcatgacc tacgacacca gccaggtctc
     6781 ggatggactc gcctggccca cgacacagca cggggtgtgg gaatttgcca tgccctcggt
     6841 tcgggtgccg gggctgaagt acaagaagac aatcatgatg gactacaacc tctggtacct
     6901 gctcaacaag gccaaggacg aacccgcgcg ggccgcggag ttcaccgggg tggtgttcga
     6961 cacctacgaa cgcgcctacc aggccgcttt cgacgggaac agggcgccgg tggtggtggg
     7021 caaccacttc aacacctggt ccggcggcgc gttcaccgcg gcgacggaga agttcatggg
     7081 gtcggtgtgc gcgaaaccgg agacggtgtg cgccacctac tccgaggtcg tggaatggct
     7141 gggcctgcag gacccggcgg tgctcgacgc gttccggaaa atgccgaacg cgcagatcgc
     7201 ccaaccgagc tgatcacatt cgggtggtcc tgcttgcgtt ggataatgat aaccgatacc
     7261 agtagtgggg tcagatccac ccggagcaca cccggagacc cccgtgaaga tcgccttcgt
     7321 cggcaagggc ggcagcggca agaccacgct ggcgtcgttg ttcctgcgcc acctcgccgc
     7381 ggaaaccccc gcgccgcccc tgctcggcat cgacgccgac atcaaccagc acctggccgc
     7441 cgcactcggt gccggggacg accaccagca gcccaccctc ggtgagcaca tgtcggtcat
     7501 caaggaccac ctgcgcggcg acaacccgcg ggtgcactcg gcgggcgaca tgatcaagac
     7561 gaccccgccc ggccgcggct cgcggttgat cgggatcgac gacgacaacc cgctctacac
     7621 ccggttcgtc cgcgtggtcg acggcgtccg gctggccgcc accgggccgt tcaccgagtc
     7681 cgacctcggg gtgtcctgct accactcgaa ggtcggcgcg gtcgagctgc tgctcaacca
     7741 catggtcgac ggcgcgggag aatacgcggt ggtcgacatg accgcggggg ccgattcgtt
     7801 cgcctccggg ctgttcaccc gattcgatgt caccttcctg gtgtgcgagc ccacgctgcg
     7861 cagcgtcggg gtgtaccgcc agtacctcga ctacgcgcgc gacttcgacg tgcgggtcgc
     7921 ggtggtcggc aacaaggtca tcgatgccga cgacgtcgcc ttcctgcgcc agcacgtcgg
     7981 tgccgacctg ctcacctgga tcggccgctc cgaccacgtc cgcgcggcag aacgcggcga
     8041 catccggccg gtcgagcagc tcgaaccggc caaccgcgac gcgctgcgct cgatgcgcgc
     8101 cctggtcgac ggggtcgagc aggactggcc gaagttccac cggcagaccg tggagttcca
     8161 cctgcgcaac gccaccgcgt gggccaacgg ccgcgcgggc cgcgacctgg ccgaccaggt
     8221 cgaccccggg ttcgtgccgg gaccggtgtc gctggcgggc tagcggaggg ggtcaacggt
     8281 tcccggcagg caggtgccca cgtggcatcc cggggctgtt gtgccccctc tgcggggtga
     8341 tgtgtcaccc ggtcgagcgg ccttcatgtt gccgccggtg gcctcgcggg tacggtcgtc
     8401 ccatgggccc ccagcaggat caccccgagt tcggcgtgtc gcggcacggc tacgaccgga
     8461 cccaggtgaa gcggtacctc ggcaccctcg ccgagcagca cgcggcgacc accgccgagc
     8521 gcgacgaggc acgggcgcgc accgaggagt tggacggcca gctgcagctg gccaggcgcg
     8581 agatcgccgc cctcaccgaa cgcctcgaca agatcggcaa cgccgccgcc gcgtcctcgg
     8641 cccccaacgc cgccgaacgc gccgcccgcg ccgtcgccac cgccgaggcc caggccgcgg
     8701 agatcaccgc ccgcgccgag gccgccgccg acaccgcgtg gtccgccgcc gaggccgcct
     8761 ccaccgccct gcgcgaccgc taccgcgcac tgatggccga cgtggagaag cgccacaccg
     8821 aactgcacga ggcccacgaa cagctcatgt ccgacacccg cgccaaggtc gaggacatga
     8881 ccaccgccgc gacggcccgc caacgcacca ccgacgacca ggccgaacgc gaccgccagc
     8941 gcgtggaaca gcagttccag caggaactca ccacccgccg caccgacctc gacaccgaga
     9001 tcaccacggc ccgcgccacc gccaccgccg aagccacccg agtggtccag accgccaccg
     9061 acgaagccgc caagcgcatc gccacggcca ccagccaggt agaacgcctc accgccctcc
     9121 gcgaacaact agcgggtcgc ctgcgcggca cctcggaact gctaacccaa agcacccacc
     9181 tcctagaacc cctggccgca gagtccgaaa tggacgaact agccgccaac gcccccaccg
     9241 ccaagaacct ccccatcccc cagaaaacca gctaacccca cccctccgcc ccaccccacc
     9301 actcggcgcc ccacccctcc ctcggcgccc ccgcccccgc ccccgccgct caagatcaac
     9361 tccgctccgg gggcccaccc tcccggggcc cggggcccca tctctgaacc tatcgccccc
     9421 gccgatctgt caatagggct tggccggggg ctgtggatgg ttgccggggt tgtggacaag
     9481 tccccgggct gaacgatcgc cggcccatag cggccggccc aagccgggtg aacacttggc
     9541 gacggcggtc tccacccggc cttcacgatc gttggccccc acgcgccccc gaacaacgtt
     9601 ggccgaccac gcgctcctcg gagtcgctgg tgccaaccca gctcgatggg gcggacttgt
     9661 tttgtgtggg ggaggactgc ccgtagcgtc gttcgcggac agggccatgc ttttcggccc
     9721 ctgctttgcg gtcctgccac gggtagttca ggggccccgc gcaaaacaag ttcgccgcat
     9781 cgagcaaagc tcgaaactcg cgccaggcca atgccgaagg cgaggcgttg atcatcgacg
     9841 gcgaagccga gcaagagagc cggacacccc tcagctcaag atcaaacccg ccacagcagc
     9901 ccccgataca cagcttaccg accagcaccg acaaaacggt cagagtgagc agtcaccctg
     9961 tggacaaccc accccctgcg gaaacccacc agcacccccc tcaccgctcc cgatgcgcca
    10021 agtgatccgc caacaccccc aagctctccg ccgccacccc caccggcgac gcctccgcca
    10081 acgccgcagc agccaacgcc aaatgccgct cagcctcaga aagcgcccac tcccgccccc
    10141 cagccgaact gatcaacccc gccacccgaa cctgctcagc agaagaaagc tcaccctcca
    10201 catccaggta cacagcagcc aactcagccc cagcaacagt tcccgagttc aacgcagcca
    10261 ccaccggcag cgacttcttg cggtgcacca gatccgcccc cggcttcccc atcgtctcgg
    10321 gatcgcccca gatccccagc acgtcatcaa ccagctggaa agccatcccc aggtgctcgc
    10381 ccatgtcgcg cagcagggcc acccggtgag cagaagcgcc gccgaagagg gcgcccaggg
    10441 cggtggcgca ggccatgacg gcgccggttt ttccggcggc catggcttcg cactcggcca
    10501 cggtgaccgt gcggcggtgc gggaagtcgg cgtcggcgct ctggccgtcc atgaggcgcc
    10561 acagggcttc ggtgagttgg ggcagggcgc ggtcggcgtg ggggcccgcg gcgaggacgc
    10621 gcagggccag ggcccacagg gcgtcgcccg ccagcagggc ggtggggacg ccgaacaccg
    10681 cccaggccgt gccccggtgc ctgcgggtgc ggtcgccgtc catgatgtcg tcgtgcagca
    10741 acgagaagtt gtgcaccagt tcgatcgcca ccgccgcggg caccgcgtcg accgggtcgc
    10801 cgccgaccgc ctgggctgac aacagggtca gcgcggagcg caccatcttg ccgctgtcgc
    10861 cgctgaccgg caggccgcag acatccagcc agccgaagtg gtagcacgct atccgcctca
    10921 tggcaggcgg gagcgagtcg acggcggcac gcagcgcagg cagcaccgcg gtgcggctct
    10981 cggcaagcag ctgctcgata ccgggaccca ttcctcgcgc tttctccgtc gacctcgatg
    11041 gcggcccctg aatgatcccg tgcacctgca cacccgccgg tgatcttttc gggtgatctc
    11101 ggtgccacca cacccccgca cggcccaacc ccggccgcgc accgtggtgg gagcgctgcc
    11161 gcacaggtga aacccattca cactcgggtg acgtgccgcc cacgcatcag tggttaagga
    11221 agcaacgacc acggaccgcc cgcagccgcg gcgtccgggt ccgacacgat caccggtgtg
    11281 gcccaacgcg ctcatgcaca cggtgacgcc cgtgcgtccg cacaggtgaa ccgctgcggc
    11341 atccgcatga gccggatgga gcgaaacaat ccaccgcgtt tacaattgaa ctattaaatg
    11401 gaggagttgg tgtgaaaaat tccccccacc caggcgccgg actccgttac ggaatgacct
    11461 accggctgcc cgcgctgccc acccggtgcc cgctcgcggt gcacccggac gccgcggcca
    11521 ccgcgccgcg ggtcgaggcg tggttgcggc cgtacctggt cgactacttc ggggagtccg
    11581 aacaggacag tccggtcacc ggccactacc tccgccagga cctgcaccgc tggggcgcgc
    11641 tgtgcatgcc gcacaccagg tcggaccggt tcttcaccca acagctgtgg atgaacgccg
    11701 ccgcgctgct cgacgacgcc ttctccgcgc cgtggctgcg cgagcagtcc gccagggacc
    11761 ggctcgcccg ccagttgtgc gcggccgtcg agggaacccc cggtggcgcg accccgctgg
    11821 cccgactcct cggtgacgtc cacgccatgc tgctgcccac cgcgggcgcg ctgcgcgagc
    11881 gcttggtcca ggtcggcacg agcgtggtcg tcgacaacgc caaccagcac gacatcgggg
    11941 agttcgacga cctcgacgcc tacctcggct ccagcaggcg cgtgaacgcc tacgggtact
    12001 ggatcctcac cctcgccgag tgggcgctcg gcgtcgacct cggtggcctc gtcgacgagg
    12061 acccgttggt gcgcaaggcg tgcgcgctcg ccatcgacca ctggatcctg gtcaacgacc
    12121 tctactcctt cgccaaggag atcgaggagg gcgagaagat caacgccgtc tgggtcctgt
    12181 tgggacaggg cgcgccgctg caggaggcgc tcgacgccat cgccgcccgc gcggtggcca
    12241 ccgaggagcg gttcatcgcc accagggaca agatctcccg cggcccgctg cgccgccgcg
    12301 acgacctcgc ccggttcctg gccgaggtcg gccacatgat caccggcaac ctccggcacg
    12361 cccgcgagag cagtcgctac cacggcgatg gccaccgggt ggccgacgac ctggcgggca
    12421 accccgtcgc cgagcagcgg accctggtcc ggctgggcac ggtgcaccag ccgctggccg
    12481 actagcggac ctcgcgctcc agcagcggcc ggacccgggt ggggatcggc gtggacagcg
    12541 cgatcgaggt cgacgtccgg cgcacccact cgacgttgac cacccggtcg atcacccgct
    12601 gcaggtcggc gttgttctgc gcgaccatcc gcaccagcag gtcgccctcg ccggtggtgg
    12661 cgtgcacctc gcacacctcg gggatggcgt gcagccgggt ggcgacctcg ccgcgcttgc
    12721 cctgggcgat ctccagcacg gcgaacgcgg tcagcccgta gcccatcgcg gccaggtcga
    12781 ccgcgggcgg gaacccggtg agcaccccgc gcctctccag ccggtccatc cgcgcttgca
    12841 ccgtgccgcg cgcgacgccg agcctgcgcg agcactccag cacccccaac cggggttcgt
    12901 cggtgagcag cagcagcagt cgggcatcga gcacgtcgat cccgggactt tcctcggtcg
    12961 tcacgtctct ccttgagcag agtgttcagt ttgccagaca cgcatggtga caccctagtc
    13021 atcttgtcca gtgatcttcg caagtgttgc gcaggatgca ctggggtacc catgctgcgt
    13081 cagcaggtgc aggacgcaaa cgcaggagga acgccatgac gggcacgctc aaccgcggtg
    13141 accagggcat ggacgaggtg agcttcgacc agctccgcca gctcgtcggc ctcgtcgagt
    13201 acgacgagag caaggacccg ttcccggtgc gcgccatgga cgccgtcgtc ttcgtggtcg
    13261 gcaacgccac ccagaccgcg ctgttctacc aggccgcgtt cggcatgacc caggtcgcgt
    13321 actccggtcc cgagaccggc aaccgcgacc acaagtccta cgtgctcaag tccggctccg
    13381 cccgcttcgt catcaagggc ggcgtcgacc ccaagagccc gctgctcgac caccagcgcg
    13441 cgcacggcga cggcgtcgtc gacctcgccc tcgaggtcac cgacgtggac aagtgcctgg
    13501 cgcacgcccg cgcccagggc gcgatcgtgc tcgaggaggc gcacgacgtc accgacgagc
    13561 acggcaccat ccgcgtcggc gccatcgcga cctacggcaa gacccggcac agcctgatcg
    13621 accgctcccg ctacaacggc gtctacctgc ccggctacgt cgagaaggcc ggtgcgtaca
    13681 agaagcccga gggcgccccg aagcgcatct tccaggccgt cgaccactgc gtcggcaacg
    13741 tcgagctcgg caagatggac tactgggtcg actggtacaa ccgcgtcatg ggcttcgtga
    13801 acatggcgga gttcgtcggc gacgacatcg ccaccgagta ctcggcgctg atgagcaagg
    13861 tggtcgccaa cggcaaccac cgggtgaagt tcccgctcaa cgagcccgcg atcgcgaaga
    13921 agaagtcgca gatcgacgag tacctggagt tctacggcgg ccccggctgc cagcacatcg
    13981 cgctggccac caacgacatc atcgccaccg tgaccgccat gcgcgccgcc ggtgtcgagt
    14041 tcctcgacgt gccggactcc tactacgagg acccggagct gcgcgagcgc atcggcaacg
    14101 tgcgggtgcc gatcgagcag ctcaaggagc acgccatcct ggtcgaccgg gacgaggacg
    14161 gctacctgct gcagatcttc accaagccca ccggcgaccg gccgaccgtg ttctacgaga
    14221 tgatcgagcg gcacggctcg ctcggcttcg gcaagggcaa cttcaaggcc ctgttcgagg
    14281 cgatcgagcg cgagcaggac cgccggggca acctgtaacc accagcgctg gtcgtggccc
    14341 ccgcccggat cccgggcggg ggccacactc agctactgct caggtgcggt ggcgggtggg
    14401 cgggtacgct cgcacccagg gcgatatcca cctcggggag aaccatggcc acctcacgca
    14461 gggcgatgcc actggcaggc gccgctgccg ccgcgctggt gctggccggg gtggccgtgt
    14521 tcaccgtcag caacgccggg tgcgccagcg cgggggagtt cgtgcagcgc ggccagggcc
    14581 tcgagctcgt cggcgggtgc gtcgaccccg ctgacctgcc gcccgcctcc agcacgccga
    14641 ccgtcggcac caacccgggc agcgccgtgg agcggttcca ccaggtcagc ccgtagcccg
    14701 aggttccgcg aaagaggccc gatccccact cgggggaccg ggcctcgttg tcgtccgggg
    14761 ggggggctag tccagggcct tgagcaggtc gttcaccagg tcggtgccgt cctcgatgcc
    14821 gaccgacagg cgcaggatgt cgcccgcgat ctgcagcggc gacccggtgg tgctggcgtg
    14881 cgtcatcttg ccggggtgct cgatgagcga ctcgatgccg ccgagcgact cggcgaggat
    14941 gaacagcttg gtgcgggcgg ccaccgcgag cgcggcctcc tcgccaccgg cgaccgagaa
    15001 cgacaccatc ccgccgaagc gccgcatctg cttggcggcg acctcgtggc cggggtgctc
    15061 gggcaggccg gggtagtaga ccttggtgac cttcgggtgg ttgagcagcg cctcgacgat
    15121 gcgctcggcg ttgtcgctgt gccgctccat ccgcagcgcc agcgtcttcg ccccgcgcag
    15181 caccagccac gcgtcgaacg ggctgggcac cgcgcccgcg gcgttgcgca ggaacgcgaa
    15241 cttgtcgcgc aggtcgtcgt cggaggtgat gagcgcgccg ccgaccacgt cggagtggcc
    15301 gccgaggtac ttggtggtcg agtgcagcac cacgtcggcg ccgaggccga gcggggactg
    15361 caggtacggg gtggcgaagg tgttgtcgat gaccagcttc gcgccgccct cggcggcgac
    15421 cgcggccagc gcggcgatgt cggcgatgcc cagcagcggg ttggtcggcg tctccgacca
    15481 gatgaccttg gtggtcgggc gcagcgcggc cctggtggcg gtcaggtcgg acaggtcgac
    15541 cgaggtgtac tcgacgcccc actgggtgag gaccttgtcg agcagccgga aggtgccgcc
    15601 gtaggcgtcg ttgcccagga tgacgtggtc gcccggcctg gtcatcgagc gcagcgccac
    15661 gtcggaggcg gcgaggccgg aggcgaaggc caggccgtgc ttgccgccct cgagcgcggc
    15721 gagcgcctgc tccagcgcgg tcctggtcgg gttggcgctg cgcgagtact cgtacccgcc
    15781 ctcgcgcacg ccgccgacgc cgtcctgggc gaaggtggag gtggcgtaga tgggcacgat
    15841 caccgagccg gtgcgcggat cgggttcttg tccagcgtgg atcgccctgg tctcgaaacc
    15901 ccagcgcgac gtctcgtctg ccatgtcccc caggttacgg ggaaccgccc aaccgaccac
    15961 catgtgggac cgttcccact atgaggaata tttcactgat cgagtgatga ctggtggtaa
    16021 ggccgtgcgg tacaagtccg cacggccccg atccaggtcc cgcctcgggt cgatcagtac
    16081 cgggccgcgc cgcgcagcca ccgaccggtg gacggcagca ccgcgaagaa gaaggccaga
    16141 atgcccgcga tagcgccgac ggcgagcaga atggtgtagg tgtcgttgaa ctcggtgagc
    16201 gcctggaaat agtcgccgat tccgagcccg atgccgcgca gcaattccga gacgaacggt
    16261 tccagcggca gcgaggcgac gccgagcacc gcggtgatcg cgaccaccgg cacccccgcc
    16321 ctgcgccgcg cgaacagcat caccgcgccg atcagggcca gcgccgcgag caccagcctg
    16381 ccgatgacca gcgactggag cccggccggg agttcgaaga catcactggc gtagggcacc
    16441 tcggccacga agtacgccga ggacccgccg atcccggccg cgatgccgag cgcgccgagt
    16501 ccggcgacga ccgccgtcgc cgggctgccc ggagccgcct gctggaattg cgggtagtag
    16561 ccctgctgct ggtacggcgc ctggtagttc acatttcccc ctcgcgtctt cctggacgac
    16621 cccaaagacg cggataggcc ccggcaggtt gccggggcct atcaactcag ttcgcgcgag
    16681 ctaccactgc tgcggcggct gcccaccggg cggctgctgg ccgaacccgc cgggcggggg
    16741 cggcgggggc tgctgcccgt agccctgctg cggcgggggg aacccgggct gctggccctg
    16801 cggcggctgg ccgtactgct gctgcggggg ctgctgctgg ccgaacccac ccggctggcc
    16861 gtactgctgc ggcggctgct gctggccgaa gccctgctgc tggtgcggct ggccgaaccc
    16921 gccgggacca ccggcaccgg ggccaccgga accgctgctg agcgagctga gcggcgaact
    16981 gccgagcagg tagtccttgg tctgcgggaa gaacgccagc gcaccggcac cggcgatgag
    17041 caggccgaac accagcgggg tcatgatctg gccgacgaag ctgaaggtcg cgccgttgag
    17101 gatcgcggcg accaccaggc cgccaccgcc gcccgcgacg agcaggtggg cgatgttcag
    17161 gttcttcttc agcgccagca ggaccgcgcc cgcgatcgcc acggccgcgc ccgcgatctg
    17221 gacgaacgac aggaacgtgt tgaacccgct cgggcagtag ctcgacgcca ccccgccgag
    17281 cccgcgcacg tcaccgcaga ggccgctgat ggtggagatg ttcgacatca gcgagatgct
    17341 catgatcagc gcgatcaggc cgagcaccgc gacggcgccg agcacgatca gcgcgatcat
    17401 gccggtgttc tggccctgac cacccgcgcc aggcgcgccg ccgagaccgg actgctgggc
    17461 gaaaccaccc ggctggccgg ggtagccgcc gggctgctgc tggccgtaac cctgctgctg
    17521 ctggccgaac ccaccgggct ggccgtactg ctgctggggc ggctgctgct ggccgtaggg
    17581 ctggtggaac ccaccggggg gcgacgcctg gtcggcggcg ctgggcggcg gggcgtaggg
    17641 cggcgactgc gagacggagc cgggcggcac catctgcgtc gcgtcaccct ggccggggcg
    17701 cacgacctgc gtgcggtcga cgccctcctc ctccccaccg ggaggggtct gacccgggcg
    17761 gatggcctgc gtccgctcga cgccgtcggc gccggtggtg tcaccgggtg gtggcgcgta
    17821 atgcggctgc ggcggggggt acccgcccgg ctgctggccg tacggcggct ggtcctgacc
    17881 gggttgacca ggccactgct ggggctgacc gccctgccat ggctggttcg gcggctgggg
    17941 agcactcatc gggtttccca ccccttttga cctggactat cagttggcaa atcagctaac
    18001 tctgcgggta acgctatcgg actcgatatc cgggcgcggt tcgcggctcg cggggtgacc
    18061 atagggcgtc agcgcccggc caggaagccc aggagatctt gcctggtcac cacacccgcg
    18121 ggcttgccgt cgaccagcac cagcgcgccg tcggcgtcgg tgagcgcggt catcgccacc
    18181 gacacctgct caccagcgcc gatggtgggc agcgggccgg acatgtgccg gtcgagccgg
    18241 tcggccagcg cggccttgcc ggtgaacagc gcgtcgagca ggtcgcgctc gttgaccgcg
    18301 ccgaccacct cggccgccat caccggcggc tcggcgttga ccaccggcat ctggctcacg
    18361 ccgaactcgc gcaggatggc caccgcgtcg gcgaccgtct cggtcgggtg ggcgtgcacg
    18421 aagtcgggga tcgtggtgcc cgaggcgctc ttgcggcgca gcacgtcacc gacggtggcg
    18481 ccggagtgct caggcggcag gaagccgtac tgggccatcc acgagtcgtt gaacaccttc
    18541 gacaggtagc cgcggccgcc gtcgggcagc agcaccacca ccacgtcgtc cgggccgagc
    18601 cgcttggcca gccgcagcgc ggcggccgcc gccatcccgc acgagccgcc gaccagcatg
    18661 gcctcctcgc gggccagcct gcgggtgacc tcgaaggact ccgagtccga caccgcgatg
    18721 atctcgtcgg cgaccgagcg gtcgtaggtc tccggccaga agtcctcgcc gacgccctcg
    18781 accaggtacg gcctgccggt gccgcccgag tagaccgaac cctccgggtc ggcgccgatg
    18841 acccgcacct tgccgccgga gacctccttg aggtagcggc cggtgccgga gatggtgccg
    18901 ccggtgccga cgcctgccac gaagtgcgtg atcttgccct cggtctgccg ccacagctcg
    18961 gggccggtcg agtggtagtg gctcgccggg ttctcccggt tggcgtactg gttcggcttc
    19021 cacgcgccct cgatctcgcg gaccagccgg tcggacacgt tgtagtagga gtccgggtgc
    19081 tcgggggcca ccgcggtcgg gcacaccacg acctcggcgc cgtacgcctt gagcacgttg
    19141 cgcttgtcct cgctgacctt gtccgggcag acgaacacgc acttgtagcc cttgcgctgg
    19201 gcgaccatgg ccaggccgac gccggtgttg cccgaggtgg gctcgacgat cgtgccgccg
    19261 gggcgcagct cgccggacgc ctcggccgcc tcgaccatgc gcagcgcgat ccggtccttc
    19321 acgctgccac ccgggttgaa gtactccacc ttcgccagca cggtcggggc gagcccgtcg
    19381 gccagggtgt tcagccgcac caggggcgtg tcaccgacga gatcaaagat gtgctcgacg
    19441 tactccaccg agggctcctt catggggtcg cgttaggggt tcgcgtcgtt gacctgctcg
    19501 tggggagcgt atcccggctc tagcgccggt gaagtaatcg ccgcgtttgg taaagaggag
    19561 gtcggcgggg gcgatagctc taagacagtc acctttggtc gaaggggggc aggcgatgct
    19621 gtggatccgt ggactctggg tggccgctgt ggcagcaggc tccgtgggcg gcctgtccgg
    19681 cgcggcgtac acgttgttgc agtcgcagtc ccgacaagcg cgcagcatca tcggtgtacc
    19741 tcgcgacctg ccgttcaacg cggacggctg ctactggccc gacggaaccg gccctgggca
    19801 ggtcgctgac gctcttacct tcggcatctt cggtgactcc accgccgcgg ggctgggcgc
    19861 tgagtcgccg gaagcgctac ctggcgtgca gctcgcaagg ggtctggccg aggagtcggg
    19921 tcgcccggtg cggctcacga cctacgcggt cgtcggctcc cgtagtaccc acctcgctga
    19981 ccaggtcgac cgcgcgctgt tagacccacc gcgggcggct gtggtcatgg tcggcggcaa
    20041 tgacgtgacg gctcggctcg gtgtggccgc gtgcgccgaa ctgcttggcg agcaggtccg
    20101 acggctggtc gcggctggca ccggtgtcgt cgtcggaacc tgccccgacc tgggcacggt
    20161 ccggccgatc ccgcagccgc tgcgctcgct ggcgcagcgg tggagcctgg ccctcggccg
    20221 tgcgcaggcc cgcgccctgg tcggcagcgg cgcggcggtg gtgcccatga ccctggtgtc
    20281 gcggcacttc gcccggcggc ccgacgagct gttcagcccg gaccggttcc accccaacgg
    20341 cgccgggtac gggctggcgg caggcgtgat cctcgcccca ctgtgcgcgg tggccggggt
    20401 gtgccacagt gcggtgacac ccggctgagc agcgtggctc cacgggtgga gttacctctc
    20461 ggtaacctca gcggtgtcgt gctggaccgg cctaccgcga aggagcaccc gccatgccag
    20521 aggcagtcat cgtctccgct gtccgctcgc cgatcggccg ggcgggcaag ggttccctgg
    20581 tcgacatccg accggacgac ctgaccgcgc agatggtccg cgccgcactg gaccgggtgc
    20641 ccgcgctcga ccccaccgac atcgacgacc tcatgctcgg ctgcggcctg cccggcggcg
    20701 agcagggcaa caacatcggc cggatcgtct cggtgctgct cggctacgac ttcctgcccg
    20761 gctgcaccgt cacccgctac tgcgcctcct cgctgcagac cacccgcatg gcgctgcacg
    20821 cgatcaaggc gggcgagggc gaggtgttca tctccgccgg ggtggagacc gtgtcgcgct
    20881 tcgccaaggg cagttccgac tcctggcccg acacccacaa cccgatcttc gccgaggccg
    20941 aggcgcgcac cgcggcggtc gccgagtccg gcgccgacga gtggcacgac ccgcggctgg
    21001 acggccgggt gcccaacgcc tacctcgcca tgggccagac cgcggagaac ctggcgctgg
    21061 ccaaggggat cacccgcgag gagatggacc acttcggcgt ccgctcgcag aaccgcgccg
    21121 agcaggcgat caaggacggc ttctgggcca gggagatcac gccggtcacc ctccccgacg
    21181 gccgcgtggt ggagaccgac gacgggccgc gcgccggggt gaactacgag aagaccgcga
    21241 ccctgcagcc ggtgttccga ccggacggtc gcgtcaccgc gggcaactgc tgcccgctca
    21301 acgacggcgc ggcggccctg gtgatcatgt ccgaccgcaa ggccgccgag ctggggctga
    21361 ccccgctggc caggatcgtc gccaccgggg tctccgggct gtcgccggag atcatgggcc
    21421 gcgggccggt cgaggcgtcc cggcgcgcgc tggccatcgc cggtctgtcc atctcggaca
    21481 tcgacctggt ggagatcaac gaggcgttcg ccgcccaggt catcccctcg gcgcgggaac
    21541 tgggcgtcga cgacgacaag ctcaacgtca acggcggcgc catcgcggtc ggccacccgt
    21601 tcggcatgac cggcgccagg atcgccacca cgctgatcaa ctcgctgcag tggcacgaca
    21661 agcagttcgg cctggagacc atgtgcgtcg gcggcggcca gggcatggcc atggtgttgg
    21721 agcggttgag ctagggctct gctgactccc tcccgccacc cgccccctca tccccacccg
    21781 gcatcgttcc cggcctggca ccgtcgcgcc ccgggtgcgt acccggcctg gcccgtcggg
    21841 tccgcgcggt tgtcctgaca caacgagaac ggccacccca tcggcacgtg gggtggccgt
    21901 tctcgttgtc gctggctggg gatcagccgc cgtacgggac cgccttggtc agggtgacct
    21961 tctgggtctt gccgttgggc aggtcgtact ccctggtctc gccctccttg gcgccgagca
    22021 gcgcgcggcc gagcggggac tcgggggagt agacctccag ctcgccctcg ccgccctcct
    22081 cgcgggtggc cagcaggaag acctcttcgt cgtcatcgcc gtcgtagcgg acggtcagca
    22141 ccatgcccgg ctcggcgatg ccgtcgttgg cgggcgcctc gcccaccttc gcgccgcgca
    22201 gcagttcctg gaggtggcgg atccgggcct cctgctggcc ctgctcctcg cgggcggcgt
    22261 ggtacccgcc gttctccttg aggtcaccct cctcgcggct ggtgttgatc ttctgcgcga
    22321 tgaccgggcg gttctcaatc agctcgtcga gctcgttctt gagccggttg taggcctcct
    22381 gggtcaacca ggtcacctgg gtgtcgctca cggtcaccaa ctcctcgtcg tactccgggc
    22441 ccgtggtcac aggccggcaa accaggcccg gtggtgcgcc cggaa
//
