LOCUS       NZ_RCDD01000002        12106 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Actinokineospora cianjurensis strain DSM 45657 Ga0180969_102, whole
            genome shotgun sequence.
ACCESSION   NZ_RCDD01000002
VERSION     NZ_RCDD01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora cianjurensis
  ORGANISM  Actinokineospora cianjurensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 1225445)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1225445)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003663795.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:08:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,669
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,552
            CDSs (with protein)               :: 6,552
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 10 of 54
            Pseudo Genes (incomplete)         :: 50 of 54
            Pseudo Genes (internal stop)      :: 2 of 54
            Pseudo Genes (multiple problems)  :: 7 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 990494
            Orig. end                         :: 1002600
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RCDD01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12106
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12106
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12106
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7106](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7106)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            457..831
                     /locus_tag="CLV68_RS18920"
                     /old_locus_tag="CLV68_3815"
     CDS             457..831
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686081.1"
                     /locus_tag="CLV68_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3815"
                     /product="DUF1844 domain-containing protein"
                     /protein_id="WP_092780448.1"
                     /transl_table=11
                     /translation="MNDASAAPGPATSDDTLDNARELADIPSVEVISRAAVMLMSAAAE
                     RLGLADEDPATSPRRDLDEARRLITALAGLVTASVEYLGPHAAPIRDGLQSLQKAFREY
                     SAFPDEPGQGPGEKFTGPVY"
     gene            913..2337
                     /locus_tag="CLV68_RS18925"
                     /old_locus_tag="CLV68_3816"
     CDS             913..2337
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1212:
                     sodium:dicarboxylate symporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686456.1"
                     /locus_tag="CLV68_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3816"
                     /product="cation:dicarboxylase symporter family
                     transporter"
                     /protein_id="WP_246009968.1"
                     /transl_table=11
                     /translation="MAGSAPIPPPHQAEPAERPRRRDRTHLLYLAVIAAVALGVLVGLL
                     FPATAKGLAPLGAAFVALVKMMISPIIFCTIVLGVGSVAKASRVGRVGGLALGYFLVMS
                     TVALGIGLLVGNLLHPGDGLRLTDAVRATGAAQVKGGESTTEFLLGLIPTSLLSSLTEG
                     QVLQTLLVALLVGFALQLMGPSGEPGLRGVGHVQRLVFRILAMIMWAAPIGAFGAIAAV
                     VGATGAGALKSLAVIMLGFYATCVLFVVVVLGLLLWAVTRLNVFSLLRYLGREFLLILS
                     TSSSEVALPRLIAKMEHLGVSKPVVGIAVPTGYSFNLDGTAIYLTMATLFVANATGSPL
                     SLGEQFSLLAFMIIAAKGAAGVSGAGLATLAGGLQSHRPDLVDGVGLIVGIDRFMSEAR
                     ALTNFAGNAVATVVIGAWTRELDHDRAVAVLAGRQPFDEATRPDAPGGDATRESPPSAA
                     PDSSARANARESAREA"
     gene            2454..3650
                     /locus_tag="CLV68_RS18930"
                     /old_locus_tag="CLV68_3817"
     CDS             2454..3650
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_3817"
                     /product="hypothetical protein"
                     /protein_id="WP_147460063.1"
                     /transl_table=11
                     /translation="MTSRWAFVAALATTGALLLRHPAPPGAVGGWGWLVPVAAIAALVA
                     LWRFPGRAWPWVLVVGGALSTADAVLWVDNWPLPAGVDEAVRLRVVSVVTSSAAVLLVL
                     GALGGAGRLLAVGHRAHGSALAGIAVGAYAVSGPLARSRFEPSIWDLVPFVAAGLAVAG
                     AAAAVLISRRDARAPAGPPWVLAAGVLAVAVSALPALDERLRLVSVVGLIVVGALTAVR
                     ATLEATALVVVAVVGIALVRAGIRLDGHPLGARPSLLAWVALVGGVLVFAALGLSAARA
                     LLFTVAATAAALVLPVFVGDGAGYALALLAVGVGLVVLSGAVAAERCGDAPLVVVVVLG
                     LVGAQAGPLGDLGLGNGLLDNNHPTWWVTLALVASAALVATGAALERYAPKSPTLVSV"
     gene            complement(3647..4888)
                     /locus_tag="CLV68_RS18935"
                     /old_locus_tag="CLV68_3818"
     CDS             complement(3647..4888)
                     /GO_function="GO:0016158 - 3-phytase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686458.1"
                     /locus_tag="CLV68_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3818"
                     /product="phytase"
                     /protein_id="WP_121392135.1"
                     /transl_table=11
                     /translation="MRTAAVVGSLVLIPLLALPAAAGLPEVRATVETQPYYDDEGADAD
                     DPAVWVDHARPERSRVVGTLKNGGLAVFDLRGAQVQHIATPPAPTPDAEAGRFNNVDVV
                     QGARVGRRVLDLAVVSDRGRDRIRVYAIDRAGVLTDVTTEAPPRAFSATEAEVDEQRTA
                     YGLTVVPDPDGGAPWVVVSRRHDTRLGVFRLADDGRGRVTYRRVDTVDLPAAFTVPGGT
                     WSPCLEPGEGPQVEGMVFDPTDGTLYAAQEDVGIWRIPVRAGHFGHPTLVDKVREFGRP
                     ATYDPATEECAFTGPPSPAAGRYLTADAEGLAIAYGKRGQKQLLASSQGDSTFVTYDIT
                     RGLPKHTGGFTIADSSTVDGVQHSDGAAVITTPLGRDYPHGLLVVHDGENSPGERESTN
                     FKFVRWERVPGSIR"
     misc_feature    complement(4835..4837)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5001..7106)
                     /locus_tag="CLV68_RS18940"
                     /old_locus_tag="CLV68_3819"
     CDS             complement(5001..7106)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="CLV68_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3819"
                     /product="YcaO-like family protein"
                     /protein_id="WP_121392136.1"
                     /sec_met_domain="YcaO (E-value: 1.5e-59, bitscore: 198.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGDTDNRIDDPTRVTPGRVASGATVDEPTQVTSRAGILSVDELT
                     QVTTTRALAAEVVAAVDAAAAVEAAAVRPARATSVQPAADAALPGDETTKMVVVPKVVE
                     APGERAVSVREWDRHLRDCLRQEFGPKVTVSGEPLVQGARLAVVRGEDPAFERRARVAK
                     LRVLTVTAADGVVELGPLAVPGEPGCAACARGRRLGAAAATVDERDPDATAVVRERDIP
                     AEAIAVVDQMLRAAVQGDKALVGYVVEVGSGEPLWHKVIPLPDCDLCGGADGIATVGIP
                     EDEDDPEALLQALAGWVDPLTGVIPWVSVSEPLTGGPYVGTAAPPHLVVGGEVRSMPIG
                     WGKGMTRHAAIVSAVGEAIERYSASLPDPDRVVWARAADLDGEVLDPREFPLYEPEQYA
                     ARGFPYVAYDRRIDHPWVRGSWLGTDKAVWVPAVFSYLAMGLLPEHLIAQGTSNGLAAG
                     TDADSAAVCATLELVERDAMMCAWLSGAKGRFVELDDTLDIEVADVVEALREAGPAVEV
                     YVLPTSAYGTTAIALAIGDGRRWPAISLGLGSDRSPRAAIRAAVLELAQTAPHLAALLR
                     DGHRAPRHAGEVREMLDHAAFYFPPARMEAFDRLRCGGTSRLADLPEPAFDTSVADLAG
                     HLGTAGIRVAVVDVTSADVATSPFRVVRAVSPDLQPISYGHGVHRAPVSRLRHRGAPIR
                     RLVHPIW"
     gene            complement(7096..7476)
                     /locus_tag="CLV68_RS18945"
                     /old_locus_tag="CLV68_3820"
     CDS             complement(7096..7476)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_3820"
                     /product="hypothetical protein"
                     /protein_id="WP_121392137.1"
                     /transl_table=11
                     /translation="MFETTELEARVVQPRRVTAASLALVDGGAGVRAWDGLKGITAPAD
                     FRLLSRGRHHARTDPGQRTGLGPHTGPGQRSGLGQATAVGRITGLGQATGLGQATGEQR
                     MRLAVVPTGRTGTDRRGPVRAG"
     gene            complement(7653..10505)
                     /gene="uvrA"
                     /locus_tag="CLV68_RS18950"
                     /old_locus_tag="CLV68_3821"
     CDS             complement(7653..10505)
                     /EC_number="3.1.25.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrA"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686461.1"
                     /locus_tag="CLV68_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3821"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_121392138.1"
                     /transl_table=11
                     /translation="MADRLVVRGAREHNLRGVDIDLPRDSLVVFTGLSGSGKSSLAFDT
                     IFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITE
                     VYDYLRLLYARAGKPHCPTCGEPISKQTPQQIVDQVLAMESGVRFQVLAPVVRGRKGEY
                     VDLFANLQTQGYSRALVDGAVHQLTDPPKLKKQEKHHISVIIDRLAVKASSKQRLTDSV
                     ETALRLADGLVELEFVDLPDNDPHRIRGFSEHLACPNGHPLGVEDLEPRSFSFNSPYGA
                     CPECTGIGVKKEVDPELVVPDDELSLADGAIAPWAGGQTAEYFVRLLTSLAETIGFRMD
                     TPWRRLTAKAQKAVLHGVSDQVHVRYKNRYGRERSYYAAYEGVIPFLERRQEQTDSEYM
                     REKYEGYMREVPCPSCRGTRLKPEILAVTLAHGTEGDKSIAEVSNMSIGECSAFLDGLK
                     LGRRESMIAGAVLKEIQARLRFLLDVGLDYLSLDRASGTLSGGEAQRIRLATQIGSGLV
                     GVLYVLDEPSIGLHQRDNHRLIETLTRLRDLGNTLIVVEHDEDTIRASDWVVDIGPGAG
                     EHGGKVVHSGTFKELLKNKESLTGAYLSGRSEIPMPAIRRAIDKKRQLTVVGAREHNLR
                     GIDVSFPLGALVSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRIKGLEHVDK
                     LVQVDQSPIGRTPRSNAATYTGVFDHMRKLFASTTEAKVRGYQPGRFSFNVKGGRCEAC
                     AGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTIAEILDMPIEEAAAFFEP
                     IKAIHRHLATLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGRTVYILDEPTT
                     GLHFEDIRKLLGVINGLVDKGNSVIVIEHNLDVIKGSDWIVDMGPEGGSGGGTVVAEGT
                     PEDVVKADGSYTGEFLAHVM"
     misc_feature    10490..10504
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            10914..>11612
                     /locus_tag="CLV68_RS18955"
                     /old_locus_tag="CLV68_3822"
                     /pseudo=""
     CDS             10914..>11612
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="CLV68_RS18955"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_3822"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVSNTSTSTTETAGAGTEQPGLPGQRRSDGVGRAQAAHQGVREA
                     WAVLHRVVADLPDPAFREPSLLPGWSRAHVVSHLARNADALVNLLTWARTGVEHPAYTS
                     RADRDADIEDGSTRVAQVIREDLYAACDRFHTAIARLGEGDWAAIVVHPSGRTLPAAEV
                     PELALFEAWNHLVDLDAGTGYADIPAGHLDRLLDLAVRPYRAHTDGLPLRLVADLPDGR
                     QRTWELAIATH"
ORIGIN
        1 tgcggacgat cccgacctgt tcgccgttgg gtccgacgag tcggacctcc ggcacgcgga
       61 tgcggtcgtt gatgcgtgtc tccgtgctga tggggcctcc ttggtccggt aatgctgtcc
      121 ggcggggcca cccgagaaga cgggaccacc ctgccggttg cgttccccgc ccgcccaggt
      181 gggcggacgt ggcacgtcca actcgcgacg tgcacggcac gtgaggtccc caaaaacagc
      241 tcggaccccg tggtgccagg tggcacgccg gggcccgctt ccaaccgatt gcccgacgac
      301 aggcgtcagg acacaccaca agaccaccgg gtcagaacct ggcggtccgc ggcaaccgga
      361 cccagctacc tcgcggtggc ctgggtggga gcgggggctc cactttgccg cccccgcgct
      421 gacgggggct ggtcgcacgt gcaagggtag cagaccatga acgacgcttc cgccgcaccc
      481 ggccccgcca cctcggacga caccctcgac aacgcgcgcg aactcgccga cattcccagc
      541 gtcgaggtga tcagccgggc cgcggtcatg ctgatgtccg ccgccgcgga gcggctcggc
      601 ctcgccgacg aggaccccgc caccagcccc cgccgcgacc tggacgaggc gcgcaggctg
      661 atcaccgcgc tggccgggtt ggtgaccgcc tcggtggagt acctcggccc gcacgccgcg
      721 ccgatccgcg acgggttgca gtcgctgcag aaggctttcc gcgagtactc cgcgttcccg
      781 gacgagccgg gccagggccc cggtgagaag ttcaccggac cggtctactg atcgcgaact
      841 ctacgaccac aagcgtgacc gcggccacac ccgggaggaa ggtggacccc ctggaccccc
      901 agggaggcag cagtggccgg ttccgccccg atcccacccc cgcaccaggc cgagcccgct
      961 gagcggccga ggcgacgcga ccgcacccac ctgctgtacc tggcggtgat cgcggccgtc
     1021 gcgctcggcg tgctggtcgg actgctgttc ccggccaccg ccaagggttt ggcgccgctg
     1081 ggcgcggcgt tcgtggcgct ggtcaagatg atgatcagcc ccatcatctt ctgcacgatc
     1141 gtgctgggcg tcggctcggt ggccaaggcg agccgggtcg gtcgggtcgg cgggctggcg
     1201 ctcggctact tcctggtgat gtcgacggtg gcgctgggca tcgggctgct ggtcggcaac
     1261 ctgctgcacc ccggcgacgg gctgcggctc accgacgcgg tgcgcgcgac cggtgcggcg
     1321 caggtcaagg gcggcgagtc gacaacggag ttcctgctcg ggctgatccc gacctcgctg
     1381 ctgtcgtcgt tgaccgaggg gcaggtgctg cagacgctcc tggttgccct gctggtcggg
     1441 ttcgcgctgc agttgatggg gccgtccggc gagccggggc tgcgcggggt cgggcacgtg
     1501 cagcggttgg tgttccggat cctggccatg atcatgtggg cggcaccgat cggcgcgttc
     1561 ggagcaatcg ccgcggtcgt tggggctacc ggcgccggag cgctcaagag cctcgcggtg
     1621 atcatgctgg ggttctatgc cacgtgcgtg ctgtttgtgg tggtagtgct gggtttgctg
     1681 ctgtgggcgg tgacgcggct caacgtcttt tccttgctgc gctacctagg ccgggagttc
     1741 ctgttgatcc tgtcgacgtc gtcgtcggag gtagcactac ctcggctgat cgcgaagatg
     1801 gagcatttgg gcgtcagcaa gccggtcgtg gggatcgcgg tgccgaccgg gtactcgttc
     1861 aacctcgacg ggaccgcgat ctacctgacc atggcgacgt tgttcgtggc caacgcgacc
     1921 gggtcgccgc tctcgctcgg cgagcagttc tcgttgctgg ccttcatgat catcgccgcg
     1981 aagggggcag ccggggtgag cggggccggg ctggcgacgc tggcgggcgg actccagtcg
     2041 caccggccgg acctggtgga cggggtcggg ctgatcgtgg gcatcgaccg gttcatgtcg
     2101 gaagcgcggg cgctgaccaa cttcgcgggc aacgcggtgg cgaccgtcgt gatcggggcg
     2161 tggacccggg agctcgacca cgaccgggcc gtcgcggtgc tcgcgggccg ccaaccgttt
     2221 gacgaggcga cccgaccgga cgcaccgggt ggtgacgcta cgcgggagtc accgccgagc
     2281 gccgcgcccg actcgtccgc acgggcgaac gcacgggaaa gcgcgcgtga ggcgtagcct
     2341 ggccgcgctg tcgttcgttg taccgcgtga gccgcccgcg accgatgccc ccggtgcggg
     2401 cggttcggcg tagcggccac ccggcgttgt tcgtgcgctg tacggtggcg atcatgacct
     2461 ctcggtgggc cttcgtcgcc gccctcgcca ccaccggcgc gctgctgctg cgccaccccg
     2521 cgccaccggg ggccgtgggc ggctggggct ggctggtccc ggtcgccgcg atcgccgcgc
     2581 tggtcgcgct gtggcggttc cccggccggg cgtggccgtg ggtgctggtg gtcggcggcg
     2641 cgctgagcac cgccgacgcc gtgctgtggg tggacaactg gccgttgccc gcgggggtcg
     2701 acgaggcggt ccggctgcgg gtggtgtcgg tggtgacgtc ctcggccgcg gtgttgctcg
     2761 tcttgggcgc tctcggcggt gcgggtcggc tgctcgcggt gggacatcgg gctcatgggt
     2821 cagcgttggc cgggatcgcg gtgggggcgt acgcggtgag tgggccgttg gcccggtcgc
     2881 ggttcgagcc ctctatctgg gacctggtgc cgttcgtggc ggcggggctc gctgtcgcgg
     2941 gggcggcggc cgcggtgctg atcagtcggc gggacgctcg ggcacccgcc ggaccgccct
     3001 gggttctcgc ggccggggtg ctggctgtgg cggtgagcgc gctgcccgcg ttggacgagc
     3061 ggctgcggct cgtgtcggtg gtggggctga tcgtcgtagg ggcgctgacg gcggtgcgtg
     3121 cgactttgga ggcgaccgcg ctggtcgtgg tcgcggtggt ggggatcgcg ttggtgcgcg
     3181 ccgggattcg cctcgatggg cacccgttgg gggcgcggcc gagtctgctc gcctgggtgg
     3241 ctctggtggg gggcgtgttg gttttcgctg ctcttgggct gagcgcggcg cgtgcgttgc
     3301 tgttcaccgt tgcggcgact gcggcggcgt tggtactacc cgtgttcgtt ggcgacggag
     3361 ccgggtatgc gttggcactg ctcgcggttg gtgtgggact ggttgtgctg tctggcgctg
     3421 ttgcggctga gcggtgcggt gacgcgccgt tggtggtggt tgtagtgctg gggctggtgg
     3481 gagcgcaggc tggacctttg ggggatctag ggctgggcaa cggtctgttg gacaacaacc
     3541 acccgacctg gtgggtgact ctggcgctgg tggcgtccgc ggcactcgtg gctaccggtg
     3601 cggccttgga gcgctatgcg ccgaagtcac ccaccctggt ctcggtctag cggatagagc
     3661 cggggactcg ctcccagcgg acgaacttga agttggtgct ctcgcgctcc cccgggctgt
     3721 tctcgccgtc gtggacgacg agcaggccgt gagggtagtc ccggccgagc ggggtggtga
     3781 tgacggcagc gccgtcactg tgctgcacgc cgtccactgt ggaggagtcg gcgatggtga
     3841 agccgccggt gtgcttcggg aggccgcggg tgatgtcgta ggtgacgaag gtgctgtcgc
     3901 cctggctgga ggctaggagc tgcttctggc ccctcttgcc gtaagcgatg gcgaggccct
     3961 cggcgtcagc ggtgaggtaa cggcctgcgg cgggggaagg cgggccggtg aaggcgcact
     4021 cctcggtggc cggatcgtag gtggcgggcc tgccgaactc gcggaccttg tcgaccaggg
     4081 tgggatggcc gaagtggccg gcgcgcacgg ggatccgcca gatgccgacg tcctcctggg
     4141 cggcgtagag ggtgccgtcg gtcgggtcga agaccatgcc ctcgacctgc ggcccctccc
     4201 ccggctccag gcacggcgac caggtgccgc ccgggacggt gaacgcggcg ggcaggtcga
     4261 ccgtgtcgac gcggcggtag gtgacgcgac cgcgaccgtc gtcggcgagg cggaacacac
     4321 cgagccgggt gtcgtggcgc ctgctgacga cgacccaggg cgcgccaccg tccggatccg
     4381 gcacgacggt gaggccgtag gcggtgcgct gctcgtcgac ctcggcctcg gtggcgctga
     4441 acgcccgcgg cggcgcctcg gtggtgacat cggtcaggac accggcgcgg tcgatcgcgt
     4501 agacccggat gcggtcccgc ccccggtcgg aaacgacggc gagatcgagc acccgccgcc
     4561 cgacccgggc accctgcacg acgtcgacgt tgttgaaccg ccccgcctcg gcgtccgggg
     4621 tcggcgcagg cggggtcgcg atgtgctgga cctgggcacc acgcaggtcg aacacggcga
     4681 gcccgccgtt cttgagcgtg ccgaccaccc gactccgctc cggccgagcg tgatcgaccc
     4741 acaccgccgg gtcgtcggcg tcagcaccct cgtcgtcgta gtagggctgc gtctccaccg
     4801 tcgccctgac ctcaggaagg ccggcggcgg cgggtaacgc gagcaacggg atcaagacca
     4861 aggagccgac aacggccgcg gtacgcatgc gcgaagatcc tgcccgccca ccctgtccac
     4921 ccggtgaaca ccgaaccacc agcccacgtg cgccagccgg cggatcaaca ccccgtcggt
     4981 gcccaagacc ggcgcccacg tcaccagatg gggtgcacca gtctgcggat gggggcgccg
     5041 cggtggcgga ggcgggagac gggggctcgg tggacgccgt ggccgtagct gatgggttgc
     5101 aggtccgggc tcacggcgcg gacgacgcgg aaggggctgg tggccacgtc ggcgctggtc
     5161 acgtcaacga cggctactcg gatgcccgcg gtgccgaggt ggccagccag gtcggcgacc
     5221 gaggtgtcga aagcgggttc ggggaggtcg gccaggcggg aggtgccgcc gcagcggagg
     5281 cggtcgaagg cttccatgcg cgcgggcggg aagtagaagg cggcgtggtc gagcatctcc
     5341 ctgacctcgc ccgcgtgccg gggggcgcgg tggccgtcgc gcaggagggc ggccaggtgg
     5401 ggggcggtct gggcgagttc gaggacggcg gcgcggatgg cggcgcgggg ggaccggtcg
     5461 gagccgaggc cgagggagat cgcgggccag cgcctgccgt cgccgatcgc gagggcgatg
     5521 gcggtggtgc cgtaggcgga ggtcggcagc acgtacacct cgaccgcggg gcccgcctcg
     5581 cgcagcgcct cgacgacgtc ggcgacctcg atgtcgaggg tgtcgtccag ttcgacgaac
     5641 cggcccttgg cgccggacag ccacgcgcac atcatcgcgt cgcgctcgac cagttcgagg
     5701 gtggcgcaca cggcggcgct atcggcgtcg gtgcccgcgg cgagtccgtt ggaggtgccc
     5761 tgggcgatca ggtgctcggg cagcaggccc atcgcgaggt agctgaacac cgcgggtacc
     5821 cagacagcct tgtctgtgcc gagccagcta ccgcgcaccc acgggtgatc gatgcgccgg
     5881 tcgtaggcaa cgtaagggaa gccgcgcgcc gcgtactgct ctggttcata gagggggaac
     5941 tcgcgcggat cgagcacttc cccgtcgagg tcagccgcac gcgcccacac caccctgtcc
     6001 gggtcaggca gggacgccga gtaccgctcg atggcctccc ctaccgccga cacgatcgcg
     6061 gcgtgcctgg tcatgccctt accccagccg atcggcatcg accggacctc gccgccgacc
     6121 actagatgcg gcggagccgc ggtgcctacg taggggccac cggtcagcgg ttcactcacc
     6181 gagacccacg ggatgacacc ggtaagaggg tcgacccaac cagccagcgc ctggagcaac
     6241 gcctcgggat cgtcctcgtc ctcggggatg ccgaccgtcg cgatgccgtc agcgccgccg
     6301 cacaggtcgc agtccggcag cgggatcacc ttgtgccaca gcggttcacc cgacccgacc
     6361 tcgacgacgt acccgacgag cgccttgtcg ccctgcaccg cggcccgcag catctggtcc
     6421 acgacggcga tcgcctcagc ggggatgtcg cgctcccgca ctaccgcggt ggcatcggga
     6481 tcgcgctcgt ccaccgtcgc cgcggccgcc ccgagccgcc tgcccctcgc gcacgccgca
     6541 caccccggct cccccggcac cgccaacggc ccgagctcca ccacgccgtc ggcggcggtc
     6601 acggtcaaca cccgcagctt cgcgacccgc gcgcgccgct cgaacgcggg atcctcaccg
     6661 cgcacgacgg caagccgcgc cccctgcacc aacggctcac cggacacggt gaccttcggc
     6721 ccgaactcct ggcgcaggca gtcccgcagg tgccggtccc actcccgcac gctcacggca
     6781 cgctcaccgg gcgcctcgac gaccttgggg acgaccacca tcttggtcgt ctcgtccccc
     6841 ggcagcgccg catcggcggc gggctgaaca gaggtagcgc gggcagggcg aacggcggca
     6901 gcctctacgg cggcggcagc gtcaacggcg gcgacgacct cggcggcgag tgcgcgcgtt
     6961 gtggtcacct gggtcagttc gtccacgctg aggatgcccg cccgtgaggt cacctgggtc
     7021 ggttcgtcca ctgtggcccc ggacgcgact cggcccgggg tcacccgcgt ggggtcgtcg
     7081 atgcggttgt ccgtgtcacc cggcacgcac tggcccccgg cggtcggtgc ccgtccgtcc
     7141 ggtcggcacg acggccagcc gcatgcgctg ctcaccagtg gcctgaccga gaccggttgc
     7201 ctggccgaga ccggttatcc gaccgacagc ggtggcctga ccgagaccgg aacgctggcc
     7261 gggaccggtg tgcgggccga gacccgtgcg ctgaccgggg tccgtgcggg cgtggtggcg
     7321 gccgcgggag agcaggcgga agtcggcggg ggcggtgatg cccttgaggc catcccacgc
     7381 gcgcacgccc gcgccgccgt cgacgagggc gagcgaggct gcggtgaccc ggcgcggctg
     7441 cacgactctg gcctcgagtt ccgttgtctc gaacactgct gtcctcctcg cacgacccgc
     7501 gacagcagtc gcggctacga ggtaggagtc agcatccgcg accgggatac accatgtcca
     7561 gatgtcgttt ccgctggtta ccgcacgtct ccgagtgaac tccggcggta gtcgccgccg
     7621 gtgacccagg ccaccggcgg cacccgtttc gatcacatca cgtgcgcgag gaactccccg
     7681 gtgtagctgc cgtcggcctt caccacgtcc tcgggtgtgc cctccgccac caccgtgccg
     7741 ccgccggagc cgccctcggg tcccatgtcg acgatccagt ccgaaccctt gatgacgtcc
     7801 aggttgtgct cgatgacgat caccgagttg cccttgtcga ccaggccgtt gatcacgccg
     7861 agcagcttgc ggatgtcctc gaagtgcagg ccggtggtgg gctcgtcgag gatgtagacg
     7921 gtgcggccgg tggagcgctt ctgcagctcg ctggccagtt tcacccgttg cgcctcgccg
     7981 ccggacaggg tcggcgcagg ctggccgagc cggacgtagc cgagacccac gtcgaccagg
     8041 gtcgccaggt gtcggtggat cgccttgatc ggctcgaaga aggcggccgc ctcctcgatc
     8101 ggcatgtcca ggatctcggc gatcgtcttg cccttgtagt gcacctccag ggtctcccgg
     8161 ttgtaccggg cgcccttgca cacctcgcac ggcacgtaca cgtccggcag gaagttcatc
     8221 tcgatcttga tggtgccgtc gccagcgcac gcctcgcagc ggccgccctt gacgttgaag
     8281 gagaaccggc ccggctggta gccgcggacc ttggcctccg tcgtcgaggc gaacagcttg
     8341 cgcatgtggt cgaacacgcc ggtgtaggtg gccgcgttgg accgcggggt gcggccgatc
     8401 ggcgactggt ccacctggac cagcttgtcc acgtgctcca ggcccttgat cctggtgtgc
     8461 ctgccgggca cctggcgggc gccgttgagc ttgttcgcca ggaccgtggc caggatgtcg
     8521 ttcaccagcg tgctcttacc cgaaccggag acaccggtga ccgacacgag cgcgcctagg
     8581 gggaacgaca cgtcgatacc gcgcaggttg tgctcacgcg cgccgacaac ggtcagctgc
     8641 cgcttcttgt cgatcgcgcg gcggatcgcg ggcatcggga tctcgctgcg gccggacagg
     8701 taggcgccgg tcagcgactc cttgttcttc agcagctcct tgaacgtgcc gctgtgcacg
     8761 accttgccgc cgtgctcgcc cgcgcccggt ccgatgtcga ccacccagtc cgaggcgcgg
     8821 atggtgtcct cgtcgtgctc gacgacgatc agcgtgttgc ccaggtcgcg cagccgggtc
     8881 agcgtctcga tcagccggtg gttgtcgcgc tggtgcaggc cgatcgaggg ctcgtcgagg
     8941 acgtagagca cgccgaccag gccggacccg atctgggtcg ccagccggat gcgctgcgcc
     9001 tcgccgccgg agagggtgcc ggaggcgcgg tcgagggaga ggtagtcgag gccgacgtcg
     9061 agcaggaacc ggagccgggc ctggatctcc ttgagcacgg cgcccgcgat catcgactcg
     9121 cgcctgccca gcttgagccc gtcgaggaac gccgagcact ccccgatgga catgttcgac
     9181 acctcggcga tggacttgtc gccctcggtg ccgtgcgcga gggtcaccgc gaggatctcc
     9241 ggcttgagcc gggtgccccg gcacgacggg cagggcacct cccgcatgta gccctcgtac
     9301 ttctcgcgca tgtactcgga gtcggtctgt tcctggcgcc gctcaaggaa cgggatcacg
     9361 ccctcgtacg cggcgtagta cgagcgctca cggccgtagc ggttcttgta gcggacgtgc
     9421 acctggtcgc ttaccccgtg cagcaccgct ttctgtgcct tcgcggtgag cctgcgccac
     9481 ggggtgtcca tccggaaccc gatggtctcg gccagcgagg tgagcagccg cacgaagtac
     9541 tccgcggtct gcccgcccgc ccagggcgcg atggcgccgt cggccagcga cagctcgtcg
     9601 tcggggacga ccagctccgg gtcgacctcc ttcttcacgc cgatgccggt gcactccggg
     9661 cacgcgccgt agggcgagtt gaacgagaac gacctcggct ccaggtcctc gacgccgagc
     9721 gggtggccgt tggggcaggc caggtgctcg gagaagccgc ggatgcggtg cgggtcgttg
     9781 tcgggcaggt cgacgaactc cagctcgacc aggccgtcgg ccagccgcag cgcggtctcg
     9841 accgagtcgg tcagccgctg cttggagctc gccttcaccg ccaaccggtc gatgatcacc
     9901 gagatgtggt gcttctcctg cttcttgagc ttcggcgggt cggtcagctg gtgcaccgcc
     9961 ccgtcgacca gcgcgcgcga gtagccctgg gtctgcaggt tcgcgaagag gtcgacgtac
    10021 tcgcccttgc ggccgcgcac gaccggggcg aggacctgga accggacccc cgactccatc
    10081 gccagcacct ggtcgacgat ctgctgcggg gtctgcttgc tgatcggctc accgcaggtc
    10141 gggcagtgcg gcttgcccgc gcgcgcgtag agcaggcgca ggtagtcgta gacctcggtg
    10201 atggtgccga cggtggaacg cgggttgcgg ctggtcgact tctggtcgat cgacaccgct
    10261 ggcgagaggc cctcgatgaa gtcgacgtcc ggcttgtcca tctggccgag gaactgcctg
    10321 gcgtaggccg agagcgactc gacgtagcgg cgctggccct cggcgaagat cgtgtcgaac
    10381 gcgaggctgg acttgcccga gccggagagc ccggtgaaca ccacgaggct gtcgcggggc
    10441 aggtcgatgt ccacgccgcg caggttgtgc tcccgggcgc cgcgaacgac gaggcggtcg
    10501 gccactgagg tcccttcggt agtgctgagc ggcggcgccg ggcgaacggc actggcgcac
    10561 tgctcatggg tcaactgctg gtgggtgtgt cactggtggg tcaactgctc gtgccatcgc
    10621 accgctgcgc gcggcccccg ccgcctcgcc cggtgtaccc gcggtcgtcg cggccgacgc
    10681 cacccggtgg cgtggaagca ccgggcacgg accgtgctcg acctgcggaa caaccctaga
    10741 gcgatggtta cggaagtggc gttggggatg ctagacgggg gcaccgacaa ttctcgcgga
    10801 ccgacctcgc ccgtgcaccc gcgacggagg tacccagcgg tagcggaccg gcttacgctg
    10861 gaggccggag cgcgttgctc cgatcacacc agcagcacca gtcgggggtg ggtatgaccg
    10921 tgtccaacac gtccacgagc acgaccgaga ccgctggagc cggcaccgaa cagcccggac
    10981 tgcctggtca gcgccgatcc gacggggtcg gccgggcgca ggccgcgcac cagggcgtcc
    11041 gcgaggcgtg ggcggtgctg caccgggtgg tggccgacct gcccgacccg gcgttccgcg
    11101 agcccagcct gctgcccggc tggagcaggg cgcacgtggt cagccacctc gcgcgcaacg
    11161 ccgacgcgct ggtcaacctg ctgacctggg cgcggaccgg ggtggagcac ccggcgtaca
    11221 ccagccgcgc cgaccgggac gccgacatcg aggacggctc gaccagggtc gcgcaggtga
    11281 tccgcgagga cctctacgcc gcgtgtgacc gattccacac cgccatcgct cgtctgggtg
    11341 agggcgactg ggccgcgatc gtcgtccacc cctccggccg gacgctgccc gcggcggagg
    11401 tccccgagct cgcgctgttc gaggcgtgga accacctggt cgacctggac gcgggcaccg
    11461 ggtacgccga catccccgcc ggtcacctcg accggctgct ggacctggcg gtccggccgt
    11521 accgggcgca caccgacggc ctcccgctgc ggctggtcgc ggacctgccg gacgggcgtc
    11581 agcgcacctg ggagctggcc atcgccaccc actcgagctc gcgggaggtc accgggcccg
    11641 cgcccgcggt cctggggtgg ctggcgggca ggtccgacgg cagcgggctg accgggacgc
    11701 cgccggagct gggctcctgg ggctgaggcc gggcgcgcag ccacgcccac gcggtcggcc
    11761 ccctggtggt gagccagcgg tgcgcgggct gctcgaccag cttggtgatc gcccagccga
    11821 gcagcagcgc catcgccacg caggccagca ggcgacccca cggtccgatg cccttgtcga
    11881 gcaggtacct ggccagcacg aagccgagct cctggtgcac gaggtacaca ccgaaggaga
    11941 tccccgcgag ccagcggatc ggcctgccca ggccgttgag gatcgcccag tccggcccgc
    12001 cggcggccgc gacgatgccc accaggacca caccgaaggc gatcgtggac ggggtgtcga
    12061 cgaagtagga gtgcgcgtcc tgggcgacga gcaccgcgac caggta
//
