LOCUS       NZ_RCDD01000001        10804 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Actinokineospora cianjurensis strain DSM 45657 Ga0180969_101, whole
            genome shotgun sequence.
ACCESSION   NZ_RCDD01000001
VERSION     NZ_RCDD01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora cianjurensis
  ORGANISM  Actinokineospora cianjurensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 3297612)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3297612)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3297612)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
REFERENCE   4  (bases 1 to 3297612)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003663795.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:08:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,669
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,552
            CDSs (with protein)               :: 6,552
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 10 of 54
            Pseudo Genes (incomplete)         :: 50 of 54
            Pseudo Genes (internal stop)      :: 2 of 54
            Pseudo Genes (multiple problems)  :: 7 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2418014
            Orig. end                         :: 2428818
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RCDD01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10804
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5804](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5804)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(35..3256)
                     /locus_tag="CLV68_RS11030"
                     /old_locus_tag="CLV68_2183"
     CDS             complement(35..3256)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="CLV68_RS11030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2183"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_147459936.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.2e-62, bitscore:
                     208.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIRTTAVLTSTTLVLGMALATTAQAAAEPSGGRAGSPAATVTLL
                     TGDKVLVGTDSGGTRRPAILPDARRAGVVFQTYTRGGHTYVFPSDALPLVLSGVLDRQL
                     FDVTALADAGYDDRRGDLPLIQTGPSTRSAGVRSVRELPVVGARALAADKAALADSWRS
                     LTAAGGKVWLDRKVEATLDRSTAQIGAPAAWQAGLTGAGVTVAVVDTGVDQTHPDLAGR
                     EVAERNFTDDPTTEDQVGHGTHVASTVAGGGAKYKGVAHGAKVIDAKVLSASGGGQLSW
                     IIAGVEWAVASGAKIVNLSLGGGDTPEVDPLEEAVNRLSAEKGTLFVISAGNSGPGAQT
                     VGTPGSADAALTVGSVERDDSVSPFSSRGPRVGDGAIKPDITAPGSGIVAAKAANGFIG
                     DEVEPGYVALSGTSMAAPHVAGAAALLAQQHPDWSGAQLKAVLTASAKPTAGAGAFAQG
                     SGRVDVARALTQSLTTTPGSVSLGTQLWPHQDDVAVTKDLTYRNSSATAVTLDVKVEGT
                     GPDGKPAPAGFFGVTPARVTVPAGGSATVEVTGDARVGTADGAYSGSVVASGPGQSLRT
                     PVALDREVESYDVRLRYLGPDGKPSKDWRTLAIGLGSDFFTGAVPDASGAVTLRLPKGS
                     YILDNLYEATGGKQDLRSLPYPAFEVKGATEVVVDARKTKPVKVTPPDPRVPLWVAVAG
                     YQVTTIEGYDIGIGIGGALFDGFSTGQIGPELPANVFIWSLSAVYYDAQANTGDFYNFA
                     WYQEKSVPTGFVRTVHRKDLATLRTKVGPSLPGSTSGRALFATSLTGRGGLLGVGRTFD
                     GDEVVEYVNAGTVQWEGSIFFGRRDQPEVDLYFVAEPVRSKAGQTHRNRVNFGVFGPAL
                     PRSAYPWAERDGDTLAFGIGLWGDGGGNAGSSAVTSAKTTLSRNGVKVGETADPGSGQF
                     TVPQGAANYRLETEATRDPAFGVSTKVSAAWTFRSDSRQTTVPLSTVRFHAPLRDDNSA
                     PVGRFTIPVSLQLENGSHVDPRNLSVNVSYDEGKTWRRAQVRGNELVLDHPRGATSVSL
                     QAKAEDGRGGTVQQTIIRAYLVNKH"
     gene            3546..4304
                     /locus_tag="CLV68_RS11035"
                     /old_locus_tag="CLV68_2184"
     CDS             3546..4304
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037170.4"
                     /locus_tag="CLV68_RS11035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2184"
                     /product="VOC family protein"
                     /protein_id="WP_121390255.1"
                     /transl_table=11
                     /translation="MVVRTTAWPVGTPCWVDLGTDVERAAAFYSALFGWRVEIGPAEFG
                     GYANCYVGEHPVAGLGPLQEGQASAWVTYLSTEDVTAGAAAIEAAGGQVVAPPMPIGAL
                     GAMTAAVDPTGAFFALWQSGTHTGSDLTAEPGSLVWADHLSADPAAAKAFYGSVLGHTY
                     REVRPDPHYSTAHLGEADEPVAGLGAAAPGTPPRWTVYFEVQDADAAVTKVIELGGSVQ
                     EGVTDTPHGRQAVVSDDQGARFVVNTSPES"
     gene            complement(4637..4969)
                     /locus_tag="CLV68_RS11040"
                     /old_locus_tag="CLV68_2185"
     CDS             complement(4637..4969)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684641.1"
                     /locus_tag="CLV68_RS11040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2185"
                     /product="hypothetical protein"
                     /protein_id="WP_121390256.1"
                     /transl_table=11
                     /translation="MSREDVAAAQGALLRAVLAGADVPPGFDAEVVRVEAAALLGKRRR
                     IVRDIDPETAGALGERFAELFADYARGNPRRSGSRFREDAAAFAEWAVEHGHLPRARRR
                     WWRKGR"
     gene            complement(5001..5804)
                     /locus_tag="CLV68_RS11045"
                     /old_locus_tag="CLV68_2186"
     CDS             complement(5001..5804)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684640.1"
                     /locus_tag="CLV68_RS11045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2186"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_121390257.1"
                     /sec_met_domain="DUF692 (E-value: 3.1e-79, bitscore: 263.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEHLGVGIGWRSEIDLTVERMLGVDFVEVVAENIHRDHLPESLR
                     VLRARGLPVLPHAVSLSLGGAEPLDTDRVEHLAAVADLLDAPLVSDHVCFVRAGGLDSG
                     HLMPVPRTRDALEVLVANVTEARSILGRPLALENIAALLEWPNAELTEARFLRELVERT
                     DCLLLVDVANMWANAKNLDADPVALLDGLPLERLAYVHVAGGMEVDGVYHDTHAHAVPQ
                     GVLDLLGELCDRVRPPGVLLERDDHYPADTVLADELAAIRAVVDR"
     gene            complement(5842..6738)
                     /locus_tag="CLV68_RS34675"
                     /old_locus_tag="CLV68_2187"
     CDS             complement(5842..6738)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="CLV68_RS34675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2187"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_121390258.1"
                     /transl_table=11
                     /translation="MDRPWGVSGPDFLRLYLVAIAFAALLAAAVRIKARGGRVEGQARL
                     SVEELAYLAGGARRVVELAITRLLDKGKLRATRDGRLSVVSGTKAGKRDDEVDAAVLRV
                     IQQRGHGSTWVLVSAVAGRGVVTAIGAALARQGLVVGGRRRWARRSALPMAVVAAVGVA
                     RWVGEVGGESEPGWLTLAVIGAIGLAVLIASVPVPERTYAGERVLRETRQARRTGSPTA
                     DQYVFTGSVGVVVFAGLAGHPDETVARFATASRTHSTADGSSGAYSAGCGGGDSGGHSG
                     GCGGGGGCGGCGGGGGV"
     misc_feature    complement(6830..6845)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            complement(6935..7357)
                     /gene="msrB"
                     /locus_tag="CLV68_RS11055"
                     /old_locus_tag="CLV68_2188"
     CDS             complement(6935..7357)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645129.1"
                     /locus_tag="CLV68_RS11055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2188"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_121390259.1"
                     /transl_table=11
                     /translation="MEPVVGATPRVVKSEQEWRAHLSAKEFAVLRQAGTEPAWTGEYTD
                     TKTVGVYRCRACGAELFRSDTKFESHCGWPSFFSPLAGESIVLREDRAHGMVRTEVLCA
                     SCHSHLGHVFEGEGYPTPTDQRFCINSVSLTLVPDA"
     gene            complement(7407..7739)
                     /locus_tag="CLV68_RS11060"
                     /old_locus_tag="CLV68_2189"
     CDS             complement(7407..7739)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671917.1"
                     /locus_tag="CLV68_RS11060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2189"
                     /product="hypothetical protein"
                     /protein_id="WP_246009757.1"
                     /transl_table=11
                     /translation="MAETGTFGDSEESGDAVRRARANRFHDDLVGLDPADQEAREFAEH
                     LDRVEQVRPSYTVEGYLGGVRDFAESANRLGGHYRLTAGILAALILLGVVVAAWDALVF
                     IAGVLF"
     gene            complement(7775..9028)
                     /gene="hisS"
                     /locus_tag="CLV68_RS11065"
                     /old_locus_tag="CLV68_2190"
     CDS             complement(7775..9028)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="CLV68_RS11065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2190"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_246009758.1"
                     /transl_table=11
                     /translation="MDNSPARGTRDLLPATVAVRDHVLARITEVYHRYGYQRIETPALE
                     GIDRLTGGQGGENEKLIYRVLRRGLDETVAADTALTDLVDLGLRYDLTVPLTRFYGANQ
                     ASLPQPFRSFQFGPVWRAERPQKGRYRQFYQCDIDLLGEETVLAEVELIEATTEALAAA
                     GLSGATVRVSDRRFLSALAASVGLPEPEWAGLFITLDKLDKIGWDGVRAELSGRGLDDA
                     AVDRLQASITDLQGGDQTTLDKRLLDALPGLPEQVVADLADTATALAGVDGLAWEFDPT
                     LVRGMGYYTGQIFEITHPASKGSIAGGGRYDRLIGRSLGREVPACGFSIGFERIVDLIE
                     GTTATDAVAVLYESDVPLPVVTATAREVRQGGRTASAVRRRGKFGAQLGKLQEWGFTSV
                     LHVKDAVTPPEERPLGER"
     gene            9118..10158
                     /locus_tag="CLV68_RS11070"
                     /old_locus_tag="CLV68_2191"
     CDS             9118..10158
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684635.1"
                     /locus_tag="CLV68_RS11070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2191"
                     /product="DNA polymerase domain-containing protein"
                     /protein_id="WP_121390261.1"
                     /transl_table=11
                     /translation="MAPAEEIEVGGRTVRVSNPDKPYFAELGIVKRQVVEYFLAVGPGI
                     LGALRERPTTLERWPGGVVEGAKLSTRADHTGDAFYQKRLPKGAPDYVESARITFPSGR
                     PADEVCPTELAVVAWAANLGTLTFHPWPVSRPDVDHPDQLRVDLDPQPGTDFADAVAIA
                     HEARDLLRSLDMDAFPKTSGGRGVHLYIPIEPRWTFVEARRALIALARELERRLPERVT
                     VNWWKEERGSRVFIDYNQMARDRTIASAYSIRPTPRALVSAPVTWDELGSVRPEDFSVL
                     TMPARFAEVGDLHAPVADHAYSLEPLLDMVARDERDHSLGDLPYPPEYPKMAGEPKRVQ
                     PSKARD"
     misc_feature    10434..10447
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            10530..10724
                     /locus_tag="CLV68_RS11075"
                     /old_locus_tag="CLV68_2192"
     CDS             10530..10724
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684633.1"
                     /locus_tag="CLV68_RS11075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_2192"
                     /product="hypothetical protein"
                     /protein_id="WP_121390262.1"
                     /transl_table=11
                     /translation="MSETYLVRYVGGPLDGRVDTLDGAPDDPRSTVTHVHLHGGPKIVH
                     HYDLEYALEYGCEYRVREP"
     misc_feature    10638..10640
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 aaaggggtgg accgccgcgt tcatccactg aggactagtg cttgttcacc aggtaggcgc
       61 ggatgatcgt ctgttggacc gtcccgcctc gcccgtcctc ggccttggcc tgcaacgaca
      121 ccgaggtggc gccgcgcggg tggtcgagta cgagttcgtt gccccggacc tgggccctgc
      181 gccaggtctt gccctcgtcg taggacacgt tcaccgacag gttgcgcggg tcgacgtggc
      241 tgccgttctc cagttgcagg gacaccggga tggtgaacct gccgaccggg gcggagttgt
      301 cgtcgcgcag cggggcgtgg aagcgcaccg tcgacagcgg aacggtcgtc tgccgggagt
      361 cggagcggaa cgtccaggcc gccgagacct tggtgctcac gccgaacgcc gggtcgcggg
      421 tcgcctcggt ttccagtcgg tagttcgccg ccccttgcgg cacggtgaac tggccgctgc
      481 cgggatcagc cgtctcgccg accttgaccc cgttgcgcga caacgtggtc ttggccgagg
      541 tgaccgcgct gctgcccgcg ttgcccccgc cgtcgcccca caggccgatg ccgaacgcga
      601 gggtgtcgcc gtcgcgctcg gcccacgggt aggcggagcg cggcagcgcg ggaccgaaca
      661 cgccgaagtt gacccggttg cggtgggtct gcccggcctt ggaccgcacg ggctcggcca
      721 cgaagtacag gtcgacctcg ggctggtcgc ggcggccgaa gaagatcgag ccctcccact
      781 gcacggtccc cgcgttgacg tactcgacga cctcgtcgcc gtcgaaggtg cgcccgacgc
      841 cgagcagccc gccgcgaccg gtcagcgacg tggcgaacag cgcgcgcccg ctggtgctcc
      901 ccggcagcga cggtccgacc ttcgtccgca gcgtcgccag gtccttgcgg tgcacggtcc
      961 tgacgaaccc ggtcggcacg gacttctcct ggtaccaggc gaagttgtag aagtcgcccg
     1021 tgttggcctg ggcgtcgtag tacaccgccg acagcgacca gatgaacacg ttcgcgggca
     1081 gttccgggcc gatctgcccg gtgctgaacc cgtcgaacag cgccccgccg atgccgatcc
     1141 cgatgtcgta gccctcgatc gtggtcacct ggtagcccgc gaccgccacc cacagcggga
     1201 ccctcgggtc cggcggcgtc accttcaccg gcttggtctt gcgggcgtcg acgacgacct
     1261 cggtcgcccc cttcacctcg aacgccgggt acggcaggct ccgcaggtcc tgcttgccgc
     1321 cggtcgcctc gtacaggttg tccaggatgt aggacccctt gggtaggcgg agcgtgaccg
     1381 cgcccgaggc gtccggcacg gcaccggtga agaagtcgga cccgaggccg atcgccagcg
     1441 tccgccagtc cttgctcggt ttgccgtccg gccccaggta gcgcagccgc acgtcgtagc
     1501 tctcgacctc ccggtccagc gcgaccggcg tgcgcagcga ctggccgggg cccgacgcga
     1561 cgacgctgcc ggagtacgcg ccgtccgcgg tgcccacccg ggcgtcaccg gtgacctcga
     1621 ccgtcgccga cccgcccgcg ggtacggtca ccctggccgg ggtgacgccg aagaacccgg
     1681 caggcgcggg cttgccgtcc ggcccggtcc cctcgacctt gacgtccagg gtcaccgcgg
     1741 tggcggagct gttgcggtag gtcaggtcct tggtgaccgc gacgtcgtcc tggtgcggcc
     1801 acagctgggt gccgaggctg accgagccgg gcgtggtggt caacgactgg gtcagcgccc
     1861 tggccacgtc gacccgaccc gaaccctggg cgaacgcgcc cgcaccggcg gtcggcttgg
     1921 ccgaggcggt cagcacggcc ttgagctgcg cgccgctcca gtccgggtgc tgctgggcca
     1981 gcaacgccgc ggcaccggcc acgtgcggcg cggccatcga ggtgcccgag agcgccacgt
     2041 agccgggctc gacctcgtcg ccgatgaacc cgttggcggc cttggcggcc acgatgccgg
     2101 agccgggcgc ggtgatgtcc ggcttgatcg cgccgtcacc gacgcgcggg ccgcggctgg
     2161 agaagggcga gaccgagtcg tcgcgctcca ccgagccgac ggtcagcgcc gcgtccgcgc
     2221 tgccgggggt gccgacggtc tgcgcgccgg ggccggagtt gccagccgag atgacgaaca
     2281 gcgtcccctt ctccgccgag agccggttga ccgcctcctc cagcgggtcc acctcggggg
     2341 tgtcgccgcc gccgaggctg aggttgacga tcttggcgcc cgaggccacc gcccactcga
     2401 cgcccgcgat gatccacgac agctggccgc cgccggaggc gctgagcacc ttcgcgtcga
     2461 tcaccttcgc cccgtgcgcg acgcccttgt acttggcgcc gccgcccgcg acggtcgacg
     2521 cgacgtgcgt gccgtgcccg acctggtcct cggtggtcgg gtcgtcggtg aagttgcgct
     2581 cggcgacctc gcggcccgcc aggtcggggt gggtctggtc gacgccggtg tcgacgaccg
     2641 cgaccgtcac gcctgcgccg gtgagcccgg cctgccaggc cgcgggggcg ccgatctgcg
     2701 cggtgctgcg gtccagggtg gcctcgacct tgcgatccag ccacaccttg ccgccagcgg
     2761 cggtcagcga gcgccaggag tcggccagcg cggccttgtc cgccgcgagc gccctggcgc
     2821 cgacgaccgg cagttcccgc accgaccgca cgccggcgga gcgggtgctc gggccggtct
     2881 ggatcagcgg caggtcgccg cgccggtcgt cgtagcccgc gtcggcgagc gcggtgacgt
     2941 cgaacagctg ccggtcgagc accccggaga gcaccagcgg cagcgcgtcg gacgggaaga
     3001 cgtaggtgtg gccgccgcgg gtgtaggtct ggaacacgac cccggcgcgg cgcgcgtcgg
     3061 gcaggatcgc cggtctcctg gtgccgccgg aatcggtgcc gacgagcacc ttgtcgccgg
     3121 tgaggagggt gacggtggcc gctgggctgc ccgcccggcc gccggacggc tcggccgccg
     3181 cctgggctgt cgtcgcgagc gccatgccca ggacgagcgt tgtcgaggtg agtaccgctg
     3241 tcgtgcggat tcgcatggga gtaccccggt ccttggtcgg agaaggggaa cactgaaggg
     3301 ccggatcacc ggcagtggaa aaggaatgtc gaatgtctgg ccccagtgcc gaagaagcta
     3361 tccagggccg accccggatc gcaatccgcc aagtgactga tcgccccgac cgcgaatagc
     3421 gcaccggcgg ttcccactgg ttgggaatgg tccacaggcg acaacgtggt caggtgccgg
     3481 tgcccggcgt tagcgtggcc cggtccgcgc caccggcgga cgagttgccc accaggaggt
     3541 accccatggt cgtccgcacc accgcgtggc ccgtcggcac cccgtgctgg gtcgatctcg
     3601 gcacggacgt cgagcgcgcc gccgcgttct actccgccct gttcggctgg cgggtcgaga
     3661 tcgggcctgc cgagttcggc ggctacgcga actgctacgt cggcgagcac ccggtcgccg
     3721 gtctcggtcc gctgcaagaa ggccaggcca gcgcctgggt cacctatctg tccactgagg
     3781 acgtgacggc gggcgcggcc gcgatcgagg ccgccggcgg ccaggtcgtc gcgccaccga
     3841 tgccgatcgg cgcactgggg gcgatgacgg cggcggtcga ccccaccggg gcgttcttcg
     3901 cgctctggca gtcgggcacg cacaccggct ccgacctcac cgccgaaccc ggctccctcg
     3961 tctgggccga ccacctcagc gccgacccgg cggcggcgaa agccttctac ggcagcgttc
     4021 tcggccacac ctaccgcgag gtccggcctg atccacacta ctcgacggcg cacctgggcg
     4081 aggcggacga gccggtcgcc ggactcggtg ccgccgcacc gggaaccccg ccgcgctgga
     4141 cggtgtactt cgaggtgcag gacgccgacg cggccgtgac caaggtcatc gagctgggcg
     4201 gttcggtgca ggagggggtg accgacaccc ctcacggcag gcaggcggtg gtgtccgacg
     4261 atcagggtgc gcggttcgtg gtgaacacct cacccgagtc ctgacccggg acgcggtggg
     4321 tggtggccgt accccagtag cggccgccac ccaccagccc ccggtcgcgt gcccctggcg
     4381 ccggtccgac ggcgaggagg tcgcgttgag caggtggatc ggttgccgcg ccccggtttc
     4441 cgggcgtgcg ggcaggcgga ggcaggtggt gtggtccatc gggtcgatgc tgccgagacc
     4501 gccacgagaa cccagggcac tgacgatgat cgtgtgcggc gcgcgttctc ggtagtaggc
     4561 cgcaccgggc agcaggggcc cgacgacggc ggttgcccga ccggcctggt gacgcccccg
     4621 agcaccacca ggccggtcac cgccccttcc gccaccagcg acgcctggcc cgcggcaggt
     4681 gcccgtgctc gaccgcccac tccgcgaaag cggccgcgtc ctcccggaat cgcgaaccgg
     4741 accgccgcgg attcccgcgc gcgtagtcgg cgaacaattc agcgaaccgc tccccgagcg
     4801 cccccgccgt ttccggatcg atgtcccgca caatccgccg ccgttttccc aacaacgccg
     4861 ccgcctccac ccgaaccacc tcggcgtcga atccgggcgg cacatccgcc cccgccagca
     4921 cagcccgcaa caacgccccc tgcgccgccg ccacgtcctc ccggctcacc tggtcacctc
     4981 ggagacggac ctgcggcggc tcatcggtcg accaccgcgc ggatcgcggc cagttcgtcg
     5041 gccagcacgg tgtcggcggg gtagtggtcg tcgcgttcga gcaggacgcc cggggggcgg
     5101 acgcggtcgc acagttcgcc gagcaggtcc aggacgccct gggggacggc gtgggcgtgt
     5161 gtgtcgtggt agacgccgtc cacctccatg ccgcccgcga cgtggacgta ggcgaggcgc
     5221 tccaacggga ggccgtcgag cagggctacc gggtcggcgt cgaggttctt ggcgttggcc
     5281 cacatgttgg ccacgtcgac cagcagcagg cagtcggtgc gctcgaccag ttcccgcagg
     5341 aaccgcgcct cggtcagctc cgcgttcggc cactccagca gcgcggcgat gttctccagc
     5401 gccagcggcc tgcccaggat cgacctcgcc tcggtcacgt tggccaccag cacctccagc
     5461 gcgtcgcggg tgcgcgggac cggcatcagg tgtccggagt ccagcccacc ggcgcgcacg
     5521 aagcacacgt ggtcgctgac cagcggcgcg tcgagcaggt cggccaccgc ggccaggtgc
     5581 tcgacccggt cggtgtcgag cggctcggcg ccgccgaggg acaaggagac ggcatggggg
     5641 agcaccggga gccccctcgc gcgcagcacg cgcagcgact ccgggaggtg gtcgcggtgg
     5701 atgttctccg cgacgacctc gacgaagtcg acccccagca tccgctcgac ggtcaggtcg
     5761 atctccgacc gccagccgat gcccactccc aagtgctcac ccatgccgtc atcctccccc
     5821 tacctcccca ccccggggcg tctagacacc tccaccgcct ccgcagcccc cacaaccccc
     5881 gccgcctccg cagcccccgc tgtggccgcc ggagtcaccg ccgccgcagc ccgccgagta
     5941 cgcgccggac gagccgtccg cggtgctgtg ggtgcgggaa gccgtcgcga agcgcgcgac
     6001 cgtctcgtcc gggtgcccgg ccaggcccgc gaacacgacc accccgacgg acccggtgaa
     6061 cacgtactgg tcggccgtcg ggctccccgt ccgcctggcc tgcctggtct cccgcagtac
     6121 ccgctcaccg gcgtaggtcc gctccggcac cggcaccgac gcgatgagca ccgccagccc
     6181 gatcgcgccg atgaccgcga gggtcagcca accgggctcg gactcaccgc cgacctcgcc
     6241 cacccagcgc gccacgccga ccgcggccac gaccgccatc ggcagcgccg agcgccgcgc
     6301 ccaccgccgc cgtcccccga cgaccaggcc ctggcgcgcc agcgccgcgc cgatcgccgt
     6361 caccacaccc cggcccgcca ccgccgacac cagcacccag gtcgacccgt gcccgcgctg
     6421 ctggatgacc cgcagcaccg cggcgtcgac ctcgtcgtcc cgcttgcccg ccttggtgcc
     6481 ggaaaccacc gacaaccggc cgtcgcgggt ggcccgcagc ttccccttgt ccagcagccg
     6541 ggtgatggcg agctccacca cccgccgcgc gccgcccgcg aggtaggcca gttcctccac
     6601 gctgagcctg gcctggccct cgaccctgcc gccgcgcgcc ttgatccgca cggcggcggc
     6661 gagcagtgcc gcgaacgcga tcgcgaccag gtacagccga aggaagtcag gccctgagac
     6721 accccatggt cgatccatct ctccccctac cccggggagc gcccaccctc ggctttcccc
     6781 tgtgtcccac cgggtttccg ctcccggtcg ctgaccatgc tcggggtcgt gtgaccggcg
     6841 gcacaagcgt gcttgagcaa gacttagggg taccgagggc tggatttagg cttcttgacc
     6901 ccgccttgat gtgacccgcg ggtaggggtg cggctcaggc gtcgggcacc agggtcagcg
     6961 acaccgagtt gatgcagaag cgctgatcgg tcggcgtcgg gtagccctcg ccctcgaaca
     7021 cgtggcccag gtggctgtgg caactcgcgc acagcacctc ggtgcgcacc atcccgtgcg
     7081 cgcggtcctc gcgcagcacg atgctctcgc ctgccagcgg cgagaagaac gacggccagc
     7141 cgcagtgcga ctcgaacttg gtgtcgctgc ggaacagctc ggcaccgcac gcgcggcacc
     7201 ggtacacccc gaccgtcttg gtgtcggtgt actcgccggt ccacgcgggc tcggtgcccg
     7261 cctggcgcag caccgcgaac tccttggccg acaggtgcgc gcgccactcc tgctcggact
     7321 tgaccacgcg cggggtcgcg ccgaccaccg gttccatagc cacttgtgcg ctcactcctc
     7381 actcacgggg gcagatcgcc gacgggtcag aacaggacgc ccgcgatgaa caccagggcg
     7441 tcccacgcgg cgaccaccac gcccaacaag atgagcgccg cgagtatgcc cgcggtcagc
     7501 cggtagtggc cgccgagccg gttggccgac tcggcgaagt cgcgcacccc gcccaggtag
     7561 ccctcgacgg tgtagctcgg gcggacctgc tcgacccggt ccaggtgctc ggcgaactcg
     7621 cgcgcctcct ggtcggcggg gtcgagaccg accaggtcgt cgtggaaccg gttcgcgcgg
     7681 gcgcggcgca ccgcgtcgcc ggactcctcc gagtccccga acgtccctgt ctcggccatg
     7741 tgtccacggt aacccggcgg tccagtgacc gggcttacct ctcgccgagt gggcgctcct
     7801 cggggggcgt caccgcgtcc ttgacgtgca gcacggaggt gaagccccac tcctgcagct
     7861 tgccgagctg cgcgccgaac ttgccgcgcc tgcgcaccgc cgacgccgtg cggccgccct
     7921 ggcgcacctc ccgcgcggtc gcggtgacca cgggcagtgg cacatcggac tcgtagagca
     7981 ccgcgacggc gtcggtggcc gtggtgccct cgatcaggtc cacgatccgc tcgaagccga
     8041 tggagaagcc gcaggcgggc acctcgcggc ccagcgaacg gccgatgagc ctgtcgtagc
     8101 gcccaccgcc cgcgatggag cccttgctcg ccgggtgggt gatctcgaag atctggccgg
     8161 tgtagtaccc catgccgcgc accagggtcg ggtcgaactc ccaggccagg ccgtccaccc
     8221 cggccagcgc ggtcgcggtg tcggcgaggt cggccaccac ctgctccggg agccccggca
     8281 gcgcgtcgag caggcgcttg tccagcgtcg tctggtcgcc gccctgcagg tcggtgatgc
     8341 tcgcctggag ccggtcgacc gcggcgtcgt cgaggccgcg gccggacagc tcggcgcgca
     8401 ccccgtccca gccgatcttg tcgagcttgt cgagggtgat gaacagcccg gcccactccg
     8461 gctccggcag ccctaccgag gcggcgagcg cggagaggaa ccggcggtcc gacacccgca
     8521 ccgtggcgcc gctcaggccg gcggcggcca gcgcctcggt cgtcgcctcg atcagctcga
     8581 cctcggccag cacggtctcc tcaccgagca ggtcgatgtc gcactggtag aactgccggt
     8641 agcggccctt ctgcgggcgc tccgcgcgcc acaccgggcc gaactggaac gaccggaacg
     8701 gctgcggcag gctcgcctgg ttcgcgccgt agaagcgggt cagcgggacc gtcaggtcgt
     8761 agcgcaggcc caggtcgacc aggtcggtca gcgccgtgtc ggcggcgacg gtctcgtcga
     8821 ggccgcggcg cagcacccgg tagatcagct tctcgttctc gccgccctgc ccgccggtga
     8881 gcctgtcgat gccctccagc gccggggtct cgatgcgctg gtagccgtac cggtggtaga
     8941 cctcggtgat cctcgccagg acgtggtcgc gcacggcgac ggtcgcgggc agcaggtcac
     9001 gggtgcccct ggcggggctg ttgtccatct tcaccggtgg tggtccttcg tcgtcgaggt
     9061 gtgaccacgt taccgagccg cgcgcgcggt tttccggccg cccgtaggct tggcggcatg
     9121 gcgccagcgg aggagatcga ggtcggcggg cggaccgtgc gggtgtccaa tccggacaag
     9181 ccgtacttcg ccgagctggg catcgtcaag cggcaggtgg tcgagtactt cctggcggtg
     9241 ggccccggca tcctcggcgc gctgcgtgag cgcccgacca cgctggagcg ctggccgggc
     9301 ggggtggtcg agggcgccaa gctctccacg cgcgccgacc acaccggcga cgccttctac
     9361 cagaagcggc tgcccaaggg cgcccccgac tacgtcgagt ccgcgcggat caccttcccc
     9421 agcggccgcc ccgccgacga ggtgtgcccc acggagctgg cggtggtcgc ctgggcggcg
     9481 aacctgggca ccctcacctt ccacccgtgg ccggtctccc gccccgacgt cgaccacccg
     9541 gaccagttgc gcgtcgacct cgacccgcag ccgggcaccg acttcgccga cgcggtcgcc
     9601 atcgcgcacg aggcgaggga cctgctgcgc tccctggaca tggacgcctt cccgaagacc
     9661 tccggcggcc gcggcgtgca cctctacatc ccgatcgaac cgcgctggac cttcgtcgag
     9721 gccaggcgcg cgctgatcgc cctggcccgc gagctggagc ggcggctgcc ggagcgggtc
     9781 acggtgaact ggtggaagga ggagcgcggc agccgcgtgt tcatcgacta caaccagatg
     9841 gcccgcgacc gcaccatcgc ctcggcgtac tcgatccgcc ccaccccccg cgccctggtg
     9901 tccgctcccg tgacctggga cgagctcggc tcggtccgcc ccgaggactt ctcggtgctg
     9961 accatgcccg cgcgcttcgc ggaggtgggc gatctgcacg cccccgtggc cgaccacgcc
    10021 tactccctcg aacccctcct cgacatggtc gcccgcgacg aacgcgacca ctccctcggc
    10081 gacctcccct atccccccga gtaccccaag atggcgggcg agcccaagcg cgtccagccc
    10141 tccaaggccc gcgactgacc cacggcgcct gcgggcccgg gtgaggcggt ctggtgccct
    10201 ggaccggaag tcggggccct cggcggtaac acccgttcgg gggcgaacga ccttccccgt
    10261 gacctcactg ggttgtcgcg ccgtttccgg gcgggggcgg cgggcgatcc cggtgggttg
    10321 gctccactgt ggtcgaacgc ggccacggcc gtccacaggg gtgcgcgtgc accgccgcgg
    10381 cagtccacga tacgcgggaa ccgccgtgcc cgcaccgatg ttgctccatc cggtggaccg
    10441 cgtccgatcc ggcggatccg gaccagccga aacgtcgccc gcagcactta cactgccccg
    10501 ataggcccga ggcggaaggg gacgaaccca tgtcggagac ctacctcgtc cgctacgtcg
    10561 gcggccccct cgacggccgc gtggacaccc tcgacggcgc cccggacgac ccccgctcca
    10621 cggtcaccca cgtccactta cacggcggcc cgaagatcgt gcaccactac gacctcgaat
    10681 acgccctcga atacggctgc gagtaccgcg tccgcgaacc ctgagtcctc acaggacaga
    10741 cccccgggcg gctactcgcg tggcccccac cgggcaggcc ccactgaaca ggctccactg
    10801 agca
//
