LOCUS       NZ_RCDD01000001        10399 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Actinokineospora cianjurensis strain DSM 45657 Ga0180969_101, whole
            genome shotgun sequence.
ACCESSION   NZ_RCDD01000001
VERSION     NZ_RCDD01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinokineospora cianjurensis
  ORGANISM  Actinokineospora cianjurensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Actinokineospora.
REFERENCE   1  (bases 1 to 3297612)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3297612)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3297612)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
REFERENCE   4  (bases 1 to 3297612)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003663795.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:08:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,669
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,552
            CDSs (with protein)               :: 6,552
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3, 1 (5S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 54
            CDSs (without protein)            :: 54
            Pseudo Genes (ambiguous residues) :: 0 of 54
            Pseudo Genes (frameshifted)       :: 10 of 54
            Pseudo Genes (incomplete)         :: 50 of 54
            Pseudo Genes (internal stop)      :: 2 of 54
            Pseudo Genes (multiple problems)  :: 7 of 54
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 267216
            Orig. end                         :: 277615
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RCDD01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5399)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    841..854
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            complement(895..3618)
                     /locus_tag="CLV68_RS01235"
                     /old_locus_tag="CLV68_0248"
     CDS             complement(895..3618)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="CLV68_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0248"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_170224022.1"
                     /transl_table=11
                     /translation="MGENTLVPGGPGLRGLLAMLLLEPNQVVSVEHVMDVLWDHEPPAT
                     ARTIVQGYVSRLRRWLSTVDPTRETRIQTTGPGYRLVVDEARIDVALARDLLAESRDRP
                     AGERAELLAMAQGLWRGPELSGIGGRVRAPELAELRLTVIEARVDADLELGRHDDVIGE
                     LAALVDTHPFREHLVGQFVLALYRCGRRAAALEIYQRFAHRAARELGLDPGPGLRELHS
                     RILRDDTTLLEQRPTPVITPRVGVLTPAQLPAAPPGFTGRDTELGWLDGIRDTADGTAP
                     AIAVLVGSAGVGKSALAVVWGTRAAADFPDGRLYASLRGFDPRHEPIEPAEVLARFLLA
                     LGVAAEHIPDDLAERAAFYRSLLAERRLLVLLDDARDSDQVRPLLPGGPGSMVLVTSRR
                     TLDGLVTHGAALRVLGTLPPEEAEAVIEHAAGPPADHERALRTRLARLCDHLPLALRIA
                     GARLVASPQWSLRELVGELADERTRLGALRVQDVDTGVRAALDLTVGGLDPVLAATLRQ
                     LGAVPGPTFGPHLLATMAGSSPEAARERLRGLAALFLVTESEPDVYGMHDLVRLYAREL
                     GADDLLPPVLRYYLVASDLCRRHLRAAADDIDYSEAEPEVPRPPVRGREDALAWFEREW
                     PNLVAAAEAGAKAGLHTQVWQLARMASEFRRVRSRRDDWEHVLRLGLDAAKAAGDRRGE
                     VLMRLSRCVLLTRFDQEHETVADAERAVAIATELRDSKLMAMGFNTVASALYGQRRYNE
                     ALAGYRKALELSGRAGYRLGEANLLNNIAQVHRNLGAPAEAVTPQAQAVAIFREVGDLG
                     FVGLALANLAELEHELNLPEAAEVHAKEAISLAEANGLDLTEAFAREVFARVLRDRGEI
                     AAARVELMLALELYRLVQSPAAQAVQAGLAALPTDV"
     misc_feature    3874..3889
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(4090..5001)
                     /gene="thpD"
                     /locus_tag="CLV68_RS01240"
                     /old_locus_tag="CLV68_0249"
     CDS             complement(4090..5001)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682488.1"
                     /locus_tag="CLV68_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0249"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_121388797.1"
                     /sec_met_domain="PhyH (E-value: 1.8e-31, bitscore: 107.5,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTTDTRHTRPVDRYPTRTAEPLAPFARTEPTVWGGRTGPIDPA
                     TLAAHDTHGYSRYDSLLSPAEVATFRAELDRLATDDAVRADERTVVERSSAEVRSIFEV
                     HRTSELIAELVRDPRVLDRARQVLGSEVSVHQSRVNYMPGFHGKGFYWHSDFETWHAED
                     GMPSPRAVSMSIALTDNYPFNGGLMVLPGSQRTFVPCVGETPAEHYKASLTEQEIGVPS
                     RAALSRLAAEHGVDQFTGTAGSALLFDSNLMHGSGNNITPFPRSNIFVVFNSVENALVE
                     PYAAAAPRPGFIAARSAEPLAR"
     gene            complement(5001..5399)
                     /locus_tag="CLV68_RS01245"
                     /old_locus_tag="CLV68_0250"
     CDS             complement(5001..5399)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947387.1"
                     /locus_tag="CLV68_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0250"
                     /product="ectoine synthase"
                     /protein_id="WP_121388798.1"
                     /sec_met_domain="ectoine_synt (E-value: 7e-51, bitscore:
                     168.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRTLAGITGTDRDVETEHWRSKRIVLAGDGVGFSVHETVLEPG
                     AVNDFWYANHIEAVFIVEGEGELLDKETGATHQLAPGSIYVLDGNERHQLRPRTRMRTL
                     CVFNPPVTGREVHDENGVYPLITEAQEG"
     gene            complement(5418..6674)
                     /gene="ectB"
                     /locus_tag="CLV68_RS01250"
                     /old_locus_tag="CLV68_0251"
     CDS             complement(5418..6674)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-357). E-value: 3.1e-71.
                     Score: 232.1. Matches aSDomain:
                     nrpspksdomains_CLV68_RS01250_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682486.1"
                     /locus_tag="CLV68_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0251"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_121388799.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1e-73, bitscore:
                     245.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFETLESEVRSYSRGWPVVFDRAVGSHLYDESGKSYVDFFAGA
                     GALNYGHNNPVLKQAVVDYIMRDGVTHALDMNTAAKRDFLETFRDVVLAPRELDYKVMF
                     PGPAGANAVEAALKLARKVTGRESIVNFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHA
                     TPMPFDNYLDGQVPDFLWFERLLADSGSGLNEPAAVIVETVQGEGGINAARVQWLRALA
                     DLCKRHGILLIVDDVQMGCGRTGPFFSFEVAGITPDIVCLSKSIGAFGFPMALTLMRPE
                     LDIWEPGEHNGTFRGVSPAFVAATEALRTYWTDDTLEKGTLAKGEQVERVMHGIADAHP
                     TAGLKVKGRGLARGLRFADGATAGAVCHAAFERGLVMETSGPDGEVAKVMPPLTITDDE
                     LDQGLGVLTESVAATLGRS"
     aSDomain        complement(5604..6608)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV68_RS01250_Aminotran_3.1"
                     /evalue="3.10E-71"
                     /label="CLV68_RS01250_Aminotran_3.1"
                     /locus_tag="CLV68_RS01250"
                     /protein_end="357"
                     /protein_start="22"
                     /score="232.1"
                     /tool="antismash"
                     /translation="DRAVGSHLYDESGKSYVDFFAGAGALNYGHNNPVLKQAVVDYIMR
                     DGVTHALDMNTAAKRDFLETFRDVVLAPRELDYKVMFPGPAGANAVEAALKLARKVTGR
                     ESIVNFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHATPMPFDNYLDGQVPDFLWFERL
                     LADSGSGLNEPAAVIVETVQGEGGINAARVQWLRALADLCKRHGILLIVDDVQMGCGRT
                     GPFFSFEVAGITPDIVCLSKSIGAFGFPMALTLMRPELDIWEPGEHNGTFRGVSPAFVA
                     ATEALRTYWTDDTLEKGTLAKGEQVERVMHGIADAHPTAGLKVKGRGLARGLRF"
     gene            complement(6721..7239)
                     /gene="ectA"
                     /locus_tag="CLV68_RS01255"
                     /old_locus_tag="CLV68_0252"
     CDS             complement(6721..7239)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682485.1"
                     /locus_tag="CLV68_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0252"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_121388800.1"
                     /transl_table=11
                     /translation="MSGETHDVLIAEPSTEDGSELWRIARDSHTLDLNSSYAYLLWCRD
                     FADTSAVAVVAGRPVGFVIGFVRPSEPDTVVVWQIAVDGDQRGKGLAGRLLDHLLDRLA
                     PRGVRHLETTITADNATSIALFGALARRRGALMRQADLFAADHFPDDHAAEDLYRIGPF
                     EPAARPVAV"
     gene            complement(7380..8423)
                     /gene="mgrA"
                     /locus_tag="CLV68_RS01260"
                     /old_locus_tag="CLV68_0253"
     CDS             complement(7380..8423)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0047834 - D-threo-aldose 1-dehydrogenase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="mgrA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155093.1"
                     /locus_tag="CLV68_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0253"
                     /product="L-glyceraldehyde 3-phosphate reductase"
                     /protein_id="WP_121388801.1"
                     /transl_table=11
                     /translation="MPFPAAPYRAEESRYDATAYRRTGRSGLRLPPVSLGLWHNFGDDR
                     PFDTGRAILRRAFDLGVTHFDLANNYGPPYGSAEANFGRVLAGDFKPYRDEIVVSTKAG
                     YDMWPGPYGEWGSRKYVLSSLDQSLTRLGLDYVDIFYSHRFDPDTPLEETVGALITAVE
                     QGKALYVGVSSYSPEATKRAAEILGGANIPLLIHQPSYSLLNRWIEPELLDTLDDLGAG
                     CIAFSPLGQGLLTDRYLDGIPEGSRASRESSLSPDFLSEQNLARVRGLDGIAKRRGQSL
                     AQLAIAWVLRDPRVTSALVGASSVGQLEANLAAVDAAPFTADELAEIDRYAVDSGIDLW
                     AQSREAG"
     gene            complement(8509..9096)
                     /locus_tag="CLV68_RS01265"
                     /old_locus_tag="CLV68_0254"
     CDS             complement(8509..9096)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV68_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV68_0254"
                     /product="hypothetical protein"
                     /protein_id="WP_121388802.1"
                     /transl_table=11
                     /translation="MAAFDDMVRRAAAGQPGALAVLRAELMTQPRAWLVDQLLATVAPS
                     SGYRPRPVELDERRLVEHTARFGSWDTTACLVGPPPPAGRLVDRECRTVHGEELLDEAK
                     DLLHALLAGDSGLTPIRRARLTLTVPDAKVAVFGFLRGTITRTPVGGGETALLVEYPEV
                     AADLVGDAVVAALRVVNGLELNEAVLYTRKAG"
     misc_feature    9085..9094
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(9158..9949)
                     /locus_tag="CLV68_RS01270"
                     /old_locus_tag="CLV68_0255"
     CDS             complement(9158..9949)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005162565.1"
                     /locus_tag="CLV68_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV68_0255"
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_121390879.1"
                     /sec_met_domain="PIG-L (E-value: 2.9e-29, bitscore: 99.8,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATLVTFHAHPDDECINCGGVMRKAADEGHRVVLVVATRGELGEV
                     DDGFLAPGEDLTSRRVAETHAAAEILGVSRVEFLGYTDSGMMGEPTNDTPGTFWTASVE
                     EAAERLAKILVEESADVLTTYDDNGGYGHPDHIQVHRVGKRAAELAGTSRVYQATANRD
                     DVREHMSAAAADAGADGADFGPQEEWEIGKPLDELTARVDVSAYVVAKRAAMRAHASQI
                     SEESFFLSMPDPVFAQAFGTEWFIRDGEGPGITETDIMAGL"
ORIGIN
        1 acgtggggtg ggccgaccgg ctcgccgaga tgatggcggc gcagcggccg gggttgcggt
       61 acgcgaacct ggcgctgcgc gggaggatgc tccagcagat catcgacgag caggtgccgg
      121 tggcgctcac cgcgcgcccc gacctggtca cgctgtgcgg cggcggcaac gacatcatca
      181 cgccgggcac cgacgtcgac gacgtggccg cgctgttcga gaccgcggtg gtcgcgctgc
      241 gcgaggcggg cagcgaggtc gtggtgttca ccggaccgga cccgaaggtg cagccgctga
      301 tccgccggtt ccgcggcaag gtcgccatct acaacggaca cctgcacgcg atcgccgagc
      361 ggcacggcgc caggctggtc gacctgtggt cgatgggcgt gctgcacgac cgcaggtcct
      421 ggtgcgacga ccggctgcac ttctccagcg agggccacca ccggatcgcg ttgcgcaccg
      481 ccgaggtgct cgacatggac gtggcgcagg actggcgcga gccgctgccc gtcgaggacc
      541 ggaaaccgtg gctgcggctg cggcaggacg acctcgcgtg gacgacgacg cacctgatcc
      601 cgtgggtgcg cagacagatc accggggagt ccctcggcga cggcctgcac cccaagcgcc
      661 cggaactggc gccggtccgc aaggacgacc gcaccgccgg ggtgtgagtg gacgtccgaa
      721 atggccgtcc acggcgacga agggcgacaa cgacgaccgg ccggctctcc ctcccccgag
      781 agcgccggcc ggtacgtcgg gccgcacccc cgtctcccgc cgcggccctg gatgaccgtg
      841 gtcaccctgc gcgcagaggg tgccggcctg cttcgcgcac cggctaagcg ttcgctaaac
      901 gtccgtcggc agcgccgcga gtccggcttg gacggcctgc gcggccggtg actggacgag
      961 ccggtagagc tccagggcca gcatcagctc caccctggcc gccgcgatct cgccgcggtc
     1021 gcgcagcacc ctggcgaaca cctcgcgggc gaacgcctcg gtgaggtcga gcccgttggc
     1081 ctccgcgagc gagatcgcct ccttggcgtg gacctcggcc gcctccggca ggttcagctc
     1141 gtgctccaat tcggccaggt tggccagcgc cagcccgacg aagccgagat cgcccacctc
     1201 gcggaagatc gcgaccgcct gcgcctgcgg ggtgacggcc tcggccgggg caccgaggtt
     1261 gcggtgcacc tgcgcgatgt tgttgagcag gttggcttcc ccgagccggt aaccggcgcg
     1321 accggacagc tccaacgcct tgcggtaacc ggccagtgcc tcgttgtagc ggcgctggcc
     1381 gtagagagcg ctcgccaccg tgttgaagcc catcgccatc agcttggagt cgcgcagttc
     1441 ggtcgcgatg gccacggcgc gctcggcgtc ggccaccgtc tcgtgctcct ggtcgaaccg
     1501 ggtgagcagc acgcaccggc tcagccgcat caggacctcg cccctgcggt cgcctgccgc
     1561 tttcgccgcg tcgagcccca ggcgcagcac gtgttcccag tcgtcgcggc gggagcggac
     1621 ccggcggaac tcgctcgcca tcctggccaa ctgccagacc tgggtgtgca ggcccgcttt
     1681 cgcgcccgcc tcggcggcgg cgaccaggtt cggccactcg cgctcgaacc aggcgagcgc
     1741 gtcctccctg ccgcgcaccg gtgggcgggg cacctccggt tccgcctcgg agtagtcgat
     1801 gtcgtccgcc gcggcgcgca agtgcctgcg gcacaggtcg gacgcgacca ggtagtagcg
     1861 cagcaccggt ggcagcaggt cgtcggcgcc cagttccctg gcgtagagcc gcaccaggtc
     1921 gtgcatgccg tagacgtccg gttcggactc ggtgaccagg aacagcgcgg ccagcccgcg
     1981 cagccgctcc ctggcggcct ccggcgagct cccggccatg gtggccaaca ggtgcgggcc
     2041 gaacgtcggc cccggcaccg cgccgagttg ccgcagcgtg gcggcgagca ccgggtcgag
     2101 cccgccgacg gtcaggtcga gcgcggcccg cacaccggtg tcgacgtcct gcacgcgcag
     2161 cgcgcccagc ctggttcgct cgtcggccaa ctcgccgacc agttcccgca gtgaccactg
     2221 tggactggcg accagccggg cgcccgcgat ccgcagcgcg agcgggaggt ggtcgcagag
     2281 ccgggcgagc ctggtgcgca gcgcgcgttc gtggtcggcg ggtggaccgg cggcgtgctc
     2341 gatgaccgcc tcggcctcct ccggcggaag ggttcccagc acccgcagcg cggcgccgtg
     2401 ggtcaccagg ccgtcgaggg tgcgcctgct ggtgaccagc accatggagc cgggcccgcc
     2461 gggcagcagc ggtcgcacct ggtcggagtc gcgggcgtcg tcgagcagca cgagcagcct
     2521 gcgctcggcc agcagcgagc ggtagaacgc ggcccgctcg gcgaggtcgt cggggatgtg
     2581 ctcggcggcg acacccaggg cgagcaggaa cctcgccagc acctcggcgg gctcgatcgg
     2641 ctcgtgcctc gggtcgaacc cgcgcaggga cgcgtagagc ctgccgtccg ggaagtccgc
     2701 ggcggcgcgg gttccccaca ccacggcgag cgcgctcttg ccgacgccag ccgagccgac
     2761 cagcacggcg atcgcgggcg cggtgccgtc cgcggtgtcg cggatgccgt ccagccagcc
     2821 gagttcggtg tcgcggccgg tgaaccccgg tggcgcggcg ggcagttgcg ccggggtgag
     2881 cacgccgacc cgcggggtga tcaccggtgt cgggcgctgt tcgagcaacg tggtgtcgtc
     2941 gcgcagtatc cggctgtgca gctcccgcag gccgggaccg gggtcgagac cgagttcgcg
     3001 ggcggcgcgg tgcgcgaagc gctggtagat ctccagtgcc gccgcgcgcc tgccgcagcg
     3061 gtagagcgcg aggacgaact gccccaccag gtgctcgcgg aacgggtggg tgtcgaccag
     3121 cgcggccaac tcgccgatga cgtcgtcgtg gcggccgagt tcgaggtcgg cgtcgacccg
     3181 cgcctcgatc acggtcagcc gcagctcggc cagttccggc gcgcggaccc ggccgccgat
     3241 gccggagagc tccggcccgc gccacagccc ctgggccatg gccagcagtt cggcgcgttc
     3301 acccgctggg cggtcgcgcg actcggcgag caggtcgcgg gccagcgcga catcgatgcg
     3361 cgcctcgtcg acgaccagcc ggtagccggg tccggtcgtc tggatcctgg tctcccgcgt
     3421 cggatccact gtggacagcc agcggcgcag cctggacacg tagccctgca cgatggtgcg
     3481 ggcggtggca ggcggctcgt ggtcccacag cacgtccatc acgtgctcga cggacacgac
     3541 ctggttcggc tccaacaaca gcatcgccag cagtccacgc aaaccgggcc cacccggcac
     3601 cagcgtgttc tcccccacca gcgcgcacac aggccccaat acgcaaaaac gcggtccgcc
     3661 ttgttccgga cgcgtgagcg cgacgtgcgc cactcggtac caccccccga tcggaccgac
     3721 tcccctaagc cggttcaagc gctcccgagg acaaacctag ggcgaaacag aacgcgcggg
     3781 cgcggttgtg gtggtagtca accggatggc ctaaccgtta tgggtcagcg ttatgaactg
     3841 atacccccgc tcaacggcag gggaatgggc cactcgccga gtgcggacac cgcacgcggg
     3901 gggcgggaac aggttcggcc ccgctgccac accgatcccg acttcggtgg gcgcggggcc
     3961 gtactccgcc gcagttggtc cacagcacgt cgggttcacc ccgagtggga accacgacca
     4021 gctcttgatc aaccggtggc agagcgtgcc ctgatggtaa cagatggatt acgcgtgatc
     4081 acgagcgggt caccgggcca gcggctccgc gctgcgcgcg gcgatgaaac cgggccgcgg
     4141 cgcggccgcg gcgtacggct cgaccagtgc gttctccacc gagttgaaaa cgacgaagat
     4201 gttcgagcgg gggaacggcg tgatgttgtt gcccgacccg tgcatcaggt tcgagtcgaa
     4261 cagcagcgcc gatcccgcgg ttccggtgaa ctggtcgaca ccgtgttccg cggcgagccg
     4321 ggagagcgcc gcgcggctcg ggacgccgat ctcctgttcg gtgagcgagg ctttgtagtg
     4381 ctccgcaggc gtctcgccga cgcacggcac gaaggtgcgc tgggaaccgg gcagcaccat
     4441 caacccgccg ttgaacgggt agttgtcggt gagcgcgatg gacatgctca ccgcgcgcgg
     4501 cgagggcatc ccgtcctcgg cgtgccaggt ctcgaagtcg gagtgccagt agaagccctt
     4561 gccgtggaag ccgggcatgt agttgacccg gctctggtgc accgacacct cggagcccag
     4621 cacctgccgc gcccggtcga gcaccctggg gtcgcgcacc agttcggcga tcagctcgct
     4681 ggtgcggtgc acctcgaaga tcgaccgcac ctcggcggac gagcgctcca cgaccgtgcg
     4741 ctcgtcggcg cgcaccgcgt cgtcggtggc caggcggtcg agttcggcgc ggaaggtggc
     4801 gacttcggcc gggctgagca ggctgtcgta acgggagtag ccgtgggtgt cgtgcgcggc
     4861 cagggtcgcc gggtcgatcg ggccggtgcg cccaccccac acggtgggtt ccgtgcgggc
     4921 aaagggggca aggggttcgg cggtcctggt cgggtaccgg tcaacggggc gggtgtgccg
     4981 ggtgtcggtg gtcagggtca tcagccctcc tgcgcttcgg tgatgagcgg gtagacgccg
     5041 ttctcgtcgt gcacctcccg gccggtgacc ggggggttga acacgcacag ggtgcgcatc
     5101 cgggtgcggg ggcgcagttg gtggcgctcg ttgccgtcga gcacgtagat ggagccgggc
     5161 gccaactggt gggtcgcgcc ggtttccttg tccagcagtt caccctcgcc ctcgacgatg
     5221 aacacggcct cgatgtggtt ggcgtaccag aagtcgttga ccgctcccgg ttccagcacc
     5281 gtctcgtgca ccgagaaccc gacgccgtca ccggccagga cgatgcgctt gctgcgccag
     5341 tgctcggtct cgacgtcgcg gtcggtgccg gtgatcccgg ccagcgtgcg gacgatcatg
     5401 ggttcctcct cgcggggtca gctccgaccc agggtggcgg cgacggactc ggtgaggacg
     5461 ccgaggccct ggtcgagttc gtcgtcggtg atggtcagcg gcggcatgac cttggcgacc
     5521 tcgccgtccg ggccggaggt ctccatcacc aggccgcgct cgaaagccgc gtggcacacc
     5581 gcgcccgcgg tggcaccgtc ggcgaagcgc agccccctgg ccagaccgcg gcccttgacc
     5641 ttgagcccgg cggtcgggtg cgcgtcggcg atgccgtgca tgacccgctc cacctgttcc
     5701 cccttggcca gcgtgccctt ctccagggtg tcgtcggtcc agtaggtgcg cagcgcctcg
     5761 gtggcggcga cgaacgccgg gctcacgccg cggaaggtgc cgttgtgctc gcccggctcc
     5821 cagatgtcga gctccgggcg catcagggtg agcgccatcg ggaagccgaa cgcgccgatg
     5881 gacttggaca ggcagacgat gtccggggtg atgcccgcga cctcgaagct gaagaacggt
     5941 ccggtgcggc cgcagcccat ctgcacgtcg tcgacgatca gcaggatccc gtgccgcttg
     6001 cacagatcgg ccagcgctcg caaccactgc acgcgcgcgg cgttgatgcc gccctcgccc
     6061 tgcacggtct ccacgatcac cgcggcgggc tcgttgaggc cgctgccgct gtcggcgagc
     6121 aggcgctcga accacaggaa gtcggggacc tggccgtcga ggtagttgtc gaacggcatc
     6181 ggggtggcgt gcaccagcgg gatgcccgcg ccgccgcgct tcatcgagtt gccggtgacc
     6241 gacagcgcgc cgagcgtcat gccgtggaag gcgttggtga agttgacgat cgactcgcgg
     6301 ccggtgacct tgcgggccag cttcaacgcg gcctcgaccg cgttggcgcc cgcggggccg
     6361 gggaacatca ccttgtagtc cagttcccgc ggcgcgagca cgacatcgcg gaaggtctcc
     6421 aggaagtcgc gcttggcggc ggtgttcatg tcgagggcgt gggtgacgcc gtcgcgcatg
     6481 atgtagtcca cgaccgcctg tttgagcacc gggttgttgt gcccgtagtt cagggcgccc
     6541 gcacccgcga agaagtccac ataggacttc ccggactcgt cgtagaggtg gctgccgacc
     6601 gcgcggtcga acacgaccgg ccagccgcgg ctgtagctgc ggacctcgga ctcgagggtc
     6661 tcgaacacac tcatcgggaa atctccctcc ccagcgggaa agtagggcaa gtggtgggcg
     6721 ctagaccgcg accggccgcg ccgcgggctc gaacggaccg atgcggtaga ggtcctcggc
     6781 ggcgtggtcg tcggggaagt ggtcggcggc gaacagatcg gcctggcgca tcagcgcccc
     6841 cctgcgcctg gccagtgcgc cgaacagcgc gatggacgtg gcgttgtcgg cggtgatggt
     6901 ggtctccagg tgccgcacgc cgcgcggggc caggcggtcg agcaggtggt cgagcagcct
     6961 gcccgcgagg cccttgccgc gctggtcgcc gtcgacggcg atctgccaca ccaccacggt
     7021 gtccggctcg ctcggccgga cgaaaccgat cacgaagccg accgggcggc ccgcgaccac
     7081 cgcgaccgcg gaggtgtcgg cgaagtcgcg gcaccagagc aggtaggcgt aagaggagtt
     7141 caggtcgagg gtgtgcgaat ctcgggcgat ccgccacagc tcggagccgt cctctgtgga
     7201 cggctcggcg atcaggacgt cgtgcgtttc cccggacata cccagggaac gtaacagcga
     7261 tgtttcgccg ggtgtggacg ggggaaaccg ctgccccgcc cgccacctgg ggtttcagcg
     7321 gatcaccggt gaggaggaca acaccgttgt tgtcctgcgc accgggatcg tgttagtgct
     7381 cagcccgcct cgcgcgactg cgcccacagg tcgatgccgg aatccaccgc gtaccggtcg
     7441 atctcggcca actcgtccgc ggtgaacggc gcggcgtcga ccgcggcgag gttggcctcc
     7501 agctggccga ccgagctggc gccgacgagt gccgaggtga ccctcgggtc gcgcagcacc
     7561 caggcgatgg ccagctgcgc caacgactgc ccgcgccgct tggcgatgcc gtcgagaccg
     7621 cgcaccctgg ccaggttctg ctcggagagg aagtcgggcg acagcgacga ctcgcggctg
     7681 gcgcgggacc cctcggggat gccgtcgagg taccggtcgg tgagcaggcc ctggccgagc
     7741 ggggagaacg cgatgcagcc cgcgccgagg tcgtcgaggg tgtcgagcag ctcgggctcg
     7801 atccaccggt tgagcagcga gtacgagggc tggtggatga gcagcgggat gttggcgccg
     7861 ccgaggatct ccgccgcgcg cttggtcgct tcaggcgagt acgacgacac gccgacgtag
     7921 agcgccttgc cctgctccac cgcggtgatc agcgcgccga ccgtctcctc cagcggggtg
     7981 tcggggtcga agcggtgcga gtagaagatg tcgacgtagt cgaggccgag cctggtcagc
     8041 gactggtcca aagaggacag tacgtacttg cgggaacccc actccccgta cggccccggc
     8101 cacatgtcgt agcccgcctt ggtggagacc acgatctcgt cgcggtaggg cttgaagtcg
     8161 cccgccagca cccggccgaa gttggcctcg gcgctgccgt agggcgggcc gtagttgttg
     8221 gccaggtcga agtgggtgac gccgaggtcg aacgcgcggc gcaggatggc ccggccggtg
     8281 tcgaacgggc ggtcgtcgcc gaagttgtgc cacaggccga gcgagaccgg cggcaaccgc
     8341 agaccgctgc gcccggtcct gcggtaggcg gtggcgtcgt agcggctctc ctcggcgcgg
     8401 tacggcgcgg ctgggaacgg catgggtctc ctcgggtcgc ggggcgctac cgggtgattc
     8461 tcgcccagca cgccgcacgg gcgccgatcg tgcctcgtgt gccgcggctc aaccggcttt
     8521 gcgggtgtag agcaccgcct cgttgagctc cagcccgttg accacccgca gcgcggccac
     8581 cacggcgtcg ccgaccaggt cggcggcgac ctccgggtac tcgaccagca gggccgtctc
     8641 gccgccgccg accggggtcc tggtgatggt gccgcgcagg aagccgaaca cggcgacctt
     8701 ggcgtcgggg acggtcaggg tgagccgggc gcggcggatc ggggtcagcc cgctgtcccc
     8761 cgccagcagc gcgtgcagca ggtctttcgc ctcgtcgagc aactcctcgc cgtgcacggt
     8821 gcggcactcg cggtcgacca gccgaccggc gggcggcggc ggcccgacca ggcacgcggt
     8881 ggtgtcccac gagccgaacc gggcggtgtg ctcgaccagg cgccgctcgt cgagctcgac
     8941 cgggcgcggc cggtagccgc tcgacggggc gacggtggcc agcagctggt cgaccagcca
     9001 ggcccgcggc tgggtcatca gctcggcgcg cagcaccgcg agcgcgccgg gctgccccgc
     9061 cgcggcccgg cggaccatgt cgtcgaaggc ggccacgacc gggaacgtaa gccgccccgg
     9121 cgcgccggga ccagcctcgt cacccgatgg tggggcctca gagaccggcc atgatgtcgg
     9181 tctcggtgat gccggggccc tcgccgtcgc ggatgaacca ctcggtgccg aacgcctggg
     9241 cgaagaccgg gtccggcatc gagaggaaga agctctcctc ggagatctgg ctggcgtgcg
     9301 cgcgcatcgc ggcccgcttg gccaccacgt acgccgagac gtcgacccgg gcggtcagct
     9361 cgtccagcgg cttgccgatc tcccactcct cctgcgggcc gaagtccgca ccatcggccc
     9421 cggcgtccgc ggcggcggcg ctcatgtgct cgcggacgtc gtcgcggttg gcggtggcct
     9481 ggtacaccct gctcgtcccg gccagctcgg cggcgcgctt gccgacccgg tgcacctgga
     9541 tgtggtcggg gtggccgtag ccgccgttgt cgtcgtaggt ggtgagcacg tcggccgact
     9601 cctcgacgag gatcttggcc agccgctcgg ccgcctcctc gaccgaggcg gtccagaagg
     9661 tgccgggggt gtcgttggtc ggctcgccca tcatcccgga gtcggtgtag ccgaggaact
     9721 ccacacggga cacaccgagg atctcggcgg ccgcgtgcgt ctcggcgacc ctgcgggagg
     9781 tgaggtcctc gcccggcgcg aggaagccgt cgtccacctc gccgagctcg ccgcgggtcg
     9841 cgaccaccag gacgacgcgg tggccctcgt cggcggcttt gcgcatgacg ccaccgcagt
     9901 tgatgcactc gtcgtcgggg tgggcgtgga aggtcaccag tgttgccatg agcaccaagg
     9961 tacccatggc gaccgacaca ccggcgggtc agccgatggc gacgcgctca gctgatggcg
    10021 acgcgctgcg gcagggctac ctgctcgacc ggcgcctcgt ccgggctgcc gtgcaggatc
    10081 gagtcgagga tctcgccgac ccggacggcc gtggcggaca ggagtgtcgc ggtgagaccg
    10141 tggctgtgct ccgcgccctg caagtagatg cccgcggtca cgttggcggc ggtgcgcacc
    10201 cggtaatccc ggccgacgac cggtaaccct gccgcgtcac gctcacacac ggcggcagcg
    10261 cggccgagga ggtcgaacgg gtcggccgga cggaaaccgg tggcgtagac gaccgcgtcg
    10321 cactccaaga cctcggtctc gccggtcggc aggaactcga cggtggcgta gacggcctcg
    10381 tcggtctcgc gggtgtagg
//
