LOCUS       NZ_CP032698            10390 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7445410
            Orig. end                         :: 7455800
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10390
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="32"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10390
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10390
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5390](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5390)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    404..419
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    1016..1030
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(1018..1029)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            complement(1183..1851)
                     /locus_tag="DWB77_RS33125"
                     /old_locus_tag="DWB77_06685"
     CDS             complement(1183..1851)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146145.1"
                     /locus_tag="DWB77_RS33125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06685"
                     /product="transcriptional regulator"
                     /protein_id="WP_120725893.1"
                     /transl_table=11
                     /translation="MTRQTRTAQEIIAATSADLAPSADDNRLVPLVEAGTAPRAALAQL
                     ALEQRHIIAADRRAFTHLAERSGRGTACAEFFGMLAEGEALALERLGAYESACGLTPET
                     IGQYRPAAGCQAYPAYVAWLALNGEPPGVALALTANFAAWGGSCSRLAVALRARYGFDD
                     EACGFFDFFASPAPELERRAVAAVASGSDDEHGEGVGGGAHYGRLLQRYESMFWNTLAP
                     "
     gene            complement(1985..3103)
                     /locus_tag="DWB77_RS33130"
                     /old_locus_tag="DWB77_06686"
     CDS             complement(1985..3103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605631.1"
                     /locus_tag="DWB77_RS33130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06686"
                     /product="hypothetical protein"
                     /protein_id="WP_120725895.1"
                     /transl_table=11
                     /translation="MHLILLSAWTALWFAVVEPNGGFSWHYLRAGGELIYQGPSGDGTG
                     GLNLYAHHPELQMGPVSFLTAGLFNPFPERTGQFLAALLMSVLGLVIVVLAGRSAAWYF
                     LGTGTNHQRLRQRVLIAGLAFIPMWIEVSVRFGHLDDVLALFFTALAVRSVTRDSAVGT
                     GVWLALAMDSKPTAVTFAALLFALPRHQWLRAGLWCAAVLAVAWAPFFLSNPHSMSAAG
                     FAIPNQPASALRWLGVADAETPGWDRPAQAALGLLLGAVAVWRGRWAAVVLLGANARIV
                     LDPSVYTYYTASVLLGTLLWDVIGQRRLVPWWSWLALLTLYGSVFAVPHDAARGLIRLA
                     FVLVSTAYVLLWPQRDRTRDRRRRQRSPSVAG"
     misc_feature    3285..3300
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.39"
                     /tool="antismash"
     gene            3295..4095
                     /locus_tag="DWB77_RS33135"
                     /old_locus_tag="DWB77_06687"
     CDS             3295..4095
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985882.1"
                     /locus_tag="DWB77_RS33135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06687"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_174248661.1"
                     /transl_table=11
                     /translation="MTEDNGYLLDNRRTEAGERFEALSALFDGSTFRHLDALGLGAGQQ
                     VWEVGAGGPSVPLGLARRVGPEERVLATDLDTGWLGGVTLPDCVEVRRHDVGRDEAPSG
                     TFDFVHARLVLVHVGDRDRALRTMAAALRPGGVLFVEDADPALQPLLCPDEYGPEQERA
                     NRLRRGFRELLAERGADLSYGRKLPRLLRELGLEEVEADAYFPVTSPAGAVLEAATVRQ
                     VRDQLVERGLADDEEIERHLASVAAGRLDLATSPMISAWGRRPS"
     gene            complement(4124..4951)
                     /locus_tag="DWB77_RS33140"
                     /old_locus_tag="DWB77_06688"
     CDS             complement(4124..4951)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="DWB77_RS33140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06688"
                     /product="tyrosinase family protein"
                     /protein_id="WP_120725897.1"
                     /transl_table=11
                     /translation="MAVRKNQADLTAAEKRRLIDALLQLKRDGRYDTFVRTHNAFIMSD
                     TDTGDRVGHRSPSFLPWHRRFLIEFEQALQSVDASVTVPYWDWTVDRTPAASLWAADFL
                     GGTGRSRDGQVMDGPFAFEAANWPVNVRVDGRTYLRRALGAAVAQLPTRAEVDGVLAMA
                     TYDMAPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGASPNDPVFWMHHAFVDKL
                     WSQWQARHPRSPYLPAAGTRDVVDLHDTMRPWNNVTPADMLDHTRYYTYDTAA"
     gene            complement(5001..5390)
                     /locus_tag="DWB77_RS33145"
                     /old_locus_tag="DWB77_06689"
     CDS             complement(5001..5390)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514978.1"
                     /locus_tag="DWB77_RS33145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06689"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_120728517.1"
                     /sec_met_domain="melC (E-value: 3.9e-45, bitscore: 152.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRPSEPSRPTRRQAIGVTAGTLTALALASSAHAAPLSTRPASDA
                     AHDAPEAFDEVFQGRRIQGLPGAGHMHHGGGYSVRIDGQELHVMRNADGTWISVVNHYE
                     TFATPRAVARAAVVELQGAALVPLV"
     gene            5916..7421
                     /locus_tag="DWB77_RS33150"
                     /old_locus_tag="DWB77_06690"
     CDS             5916..7421
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059132.1"
                     /locus_tag="DWB77_RS33150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06690"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_120725899.1"
                     /transl_table=11
                     /translation="MHDVVIVGAGPVGLFLACELGLAGCSVLVLEREPQPQSPFKAEPF
                     GMRGLSGASVGAFYRRGLLPQLLSASGMSEDPGAPTASPLRGAGHFAGMMLDPARIDVD
                     SLPYWLPSPAPRSLRTHLEAVETVLSERASGLGVDIRYGVAVTDVTQNERGAVAHAGGH
                     TYPARWLVGCDGGRSTVRKLAGFPFEGTEPQFTGYSMQVTVAVPEKLDFGFHLTPQGMY
                     LRLLPGHLAMMDFDGGAFDRSRQPTLDHLQSVLRRVSGTDVTLSEVQLATTFTDRAMQA
                     TTYRQGRVLLAGDAAHIHSPLGGQGLNLGIGDAMNLGWKLAATVRGHAPQGLLDTYTRE
                     RRPVGAAVLDWSRAQVAVMRPGPYAQAVQGVVRDLIGTRDGTTYVFERISGAWIRYDLG
                     GEHPLVGRDAPDLHLEDGSRLGDLMGDGRGVVLDFSAEQSLRPAAKNRESRLRYVAGAA
                     RNDLGLGAVLVRPDGVVVWADGRTPDRPAFEAAVSEWFGDPES"
     misc_feature    6105..6107
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7551..8642)
                     /locus_tag="DWB77_RS33155"
                     /old_locus_tag="DWB77_06691"
     CDS             complement(7551..8642)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712508.1"
                     /locus_tag="DWB77_RS33155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06691"
                     /product="phosphatidylinositol-specific phospholipase C
                     domain-containing protein"
                     /protein_id="WP_120725901.1"
                     /transl_table=11
                     /translation="MSDPRPRRFTPRPRTTLLGALAACLALASAGAGGSASAAGPETLP
                     LSGATVSGLHNTYDPAAFPYLARALDTGTSMIELDVWDDFITKEWKVSHSNPLGNSNNC
                     VNATTPAQLYTGGANKNLESCLDDIRVWLSAHPGHPPLVVKLEMKAGFQATYGMGPDKL
                     DQTIADHLGPAVFRPADLLAKPGGGQYATLDEAANAGNWPSREALAGKVMLEVIPGTVE
                     EGNPTDTLWTDVEYARHLRDLAAAGRTARAQVFPAVHNAQAGDPRSRYADASIRPWFVV
                     FDGDAATYLNGTVDTAWYDTHHYFLVMTDAQNVAPALDDKNPSPADARARVARLAAAHA
                     SVASNDWNALPEIQSLVLPRGVG"
     gene            complement(8843..9289)
                     /locus_tag="DWB77_RS33160"
                     /old_locus_tag="DWB77_06692"
     CDS             complement(8843..9289)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430726.1"
                     /locus_tag="DWB77_RS33160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06692"
                     /product="subtilase-type protease inhibitor"
                     /protein_id="WP_120725903.1"
                     /transl_table=11
                     /translation="MRKIAAVSAVTVALLANGLVGTGLGSATAAPAGAMKPMSLYPPSA
                     LVISVEPGTGNEGASVQRAVTLNCTPTPSGTHPAPAAACAELRGVQGNFSALAASGGPR
                     LCTKIWQPVTVRADGVWNGQRINYVQTYANSCMKAAGSEAVFNF"
     misc_feature    9421..9434
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.27"
                     /tool="antismash"
     misc_feature    complement(9515..9529)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.09"
                     /tool="antismash"
     misc_feature    10140..10155
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.11"
                     /tool="antismash"
     misc_feature    10177..10195
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.12"
                     /tool="antismash"
ORIGIN
        1 gaacccccgg ccggcgttgt acaccgcgtt cgtggccgcg gcgtccaggt ggttcggcgt
       61 gacgcgggtg ccttccaggt cgagcggatg gtcgcgcagc gcggcccgca gccgctcgta
      121 ggacgccttg gcctcggcgg gggtgcggcc ctggtggtag gtcgcgtcgt tcttcgccag
      181 ccacggcagg aagtcgccct cgaaccggcg ctggaagctg agcggctggc ccaccaggaa
      241 cgcctcccag ccgcgcgtca agtccaccgt gctgtccagc acgacccgct cgacgcggcg
      301 cgggaactcg gtcgcgtagt acgccccgag gacggtggcg taggagggcc cgtagtagga
      361 gattttgtcc gcgccgagca gcgcgcggta caggtccatg tcgtgcaccg cctggtcgga
      421 ggtgatgtac ggcagcagcc cgcccgagtg gcgctcgcag tccgccacga agtcacgggc
      481 ccggtcgaac gtggcacgga tcgcgggtgc cgagcggtcc cgcagatcgc cgctggagaa
      541 gaaggcgtcg accgtggcct ggtccgagca gaccacgttg gtgctggccc cgaccccgcg
      601 ctggtcgaag ctgacgatgt cgtaggcggc cgcgagtttg gggctcaggc gggccaggtt
      661 cgccgggcgc ttgtacccgg acgagccggg cccgcccgcc gccatcatga gcacgccacg
      721 cttcgtggcc gggtcggtcg cccggtgccg cgacacctgg atgctgaggc cgggcccggc
      781 gctcgggtgg taccagtccc ggggcacggc catggtggcg cactccaagg tggtggacac
      841 gcacggctgc cagtcgaggt gctggaggcg gtagcggtcg ggcacggacg cggtggcggt
      901 ggtggcggcg ctcgccgccg tgccgggcag cgccgcggtg gcgagcagcc cgcacgcgac
      961 ggccgcggcc catcgggccg gcttcctgaa caactgcatg gatctgtctc cccgttggga
     1021 ttcgttttcc cggtggtgcg tcggtcgtat cgatcgtcca ccgcccccac cccccgtctc
     1081 gatcccgcca ccaccccgat cgggggtggt acgtgtgcca ccccgaaggt ggcccagggg
     1141 tgacgacgcg cggcccggcg cccatcgcca cccgcccggc cgtcagggcg cgagggtgtt
     1201 ccagaacatc gactcgtacc tctggagcag ccggccgtag tgcgcgccgc cgcccacgcc
     1261 ctcaccgtgc tcgtcgtccg agccgctggc gacggccgcc accgccctgc gctccagttc
     1321 cggggcgggc gacgcgaaga agtcgaagaa gccgcacgcc tcgtcgtcga agccgtaccg
     1381 ggcccgcagc gccacggcca ggcgagagca agagccgccc caggcagcga agttggcggt
     1441 cagggcaagc gccacgcccg gcggctcccc gttcagcgcc agccacgcca catacgccgg
     1501 ataggcctga cagcccgccg cgggccggta ctgcccgatg gtttccggcg tgagcccgca
     1561 ggcgctctcg tacgccccga gccgttcgag cgccagcgcc tcgccctcgg cgagcatgcc
     1621 gaagaactcc gcgcacgccg tgccgcggcc cgagcgttcg gccaggtgcg tgaaggcgcg
     1681 gcggtcggcg gcgatgatgt ggcgctgctc cagggcgagt tgggcgagtg cggcccgtgg
     1741 cgccgtgccg gcctcgacga gcggcacgag gcggttgtcg tccgccgagg gggcgaggtc
     1801 cgcggaggtc gccgcgatga tctcctgggc cgtacgcgtc tgacgagtca tgggggaccc
     1861 tcttcgcagg tctggcggtg cggtcccggc cagcgtctca cgcgacgccg cccgccatct
     1921 gacggtccgt cggcgtggcc cgcgggcgtc cggtcgtcga cgcaccggcc ggtgcggccc
     1981 tccgtcaccc ggcgacggac ggagagcgct gccttcgtct gcggtcacgg gtcctgtcgc
     2041 gctgcggcca cagcaggacg tacgccgtgg acacgagcac gaaggccagc cggatcaggc
     2101 cccgcgccgc gtcgtgcggc accgcgaaca cgctcccgta caacgtcagc agggccagcc
     2161 agctccacca cgggaccagt ctgcgctgcc cgatcacatc ccacagcagg gtgccgagca
     2221 gcacggacgc cgtgtagtac gtgtagacgc tggggtccag gacgatccgc gcgttcgcgc
     2281 cgagcagcac caccgcggcc caccgccccc gccacaccgc gacggccccg agcagcaggc
     2341 cgagcgccgc ctgcgcgggc cggtcccaac ccggtgtctc cgcgtcggcc acccccagcc
     2401 agcgcagcgc ggacgcgggc tggttgggta tcgcgaaacc ggcggccgac atcgagtgcg
     2461 ggttgctgag gaagaacggc gcccaggcga cggcgagcac cgcggcacac cacagccccg
     2521 cccgcaacca ctggtggcgg ggcagcgcga agagcagcgc ggcgaacgtc accgccgtcg
     2581 gcttggaatc catcgcgagc gccagccaca ccccggtgcc caccgcactg tcacgggtca
     2641 ccgagcgcac cgcgagcgcg gtgaagaaca gggcgaggac gtcgtcgaga tggccgaagc
     2701 gcaccgacac ctcgatccac atggggatga aggcgagccc cgcgatcagg acccgctgcc
     2761 gcagccgctg gtggttggtg ccggtgccca ggaagtacca ggcggcgctg cgcccggcga
     2821 gcaccacgat caccaggccg agcaccgaca tcaggagcgc cgcgaggaac tggccggtcc
     2881 gctcggggaa cgggttgaac agtcccgccg tcaggaagct gacgggaccc atctggagct
     2941 cggggtggtg ggcgtatagg ttgagtccgc cggtgccgtc accggagggg ccctggtaga
     3001 tgagctcgcc gccggcccgc agatagtgcc aggaaaagcc gccgttgggt tccacgacgg
     3061 cgaaccagag cgcggtccag gcggagagca ggatcagatg catcctctga ctgatggccg
     3121 gcacgtgtgt tcagctcctg tttccctgcc cgatgcgaat gacgttccgt ggagcgcgcg
     3181 ggggccccgg ggaaagatgt catgcggcgc aggttcgttc tcacacgggg ccacatgtgc
     3241 cactcgccac acgccgccgg gcccgaaggg tcggccgctg ccatgatgag gatcatgacc
     3301 gaggacaacg gatacctcct ggacaaccgg cggaccgagg cgggcgagcg cttcgaggcc
     3361 ctctccgccc tcttcgacgg ctcgacgttc cgccacctcg acgccctggg cctcggcgcc
     3421 gggcaacagg tgtgggaggt gggcgccggc ggcccgtccg tgccgctcgg cctggccagg
     3481 cgggtggggc ccgaggagcg ggtgctcgcc accgacctcg acaccggatg gctcggcggg
     3541 gtcacgctgc cggactgcgt cgaggtccgg cggcacgacg tcggccggga cgaggcgcct
     3601 tcgggcacct tcgacttcgt ccacgcgcgt ctggtcctgg tccatgtcgg cgaccgggac
     3661 cgcgccctgc gcaccatggc cgcggcgctg cgccccggcg gcgtcctgtt cgtcgaggac
     3721 gccgaccccg cgctccagcc gctgctctgc cccgacgagt acggccccga acaggaacgc
     3781 gccaaccggc tgcgccgggg cttcagggaa ctcctcgccg aacgcggcgc cgatctgtcc
     3841 tacggtcgca aactcccgcg cctgctaagg gagttgggcc ttgaggaggt ggaggccgac
     3901 gcgtacttcc cggtcacctc gccggccggc gcggtcctcg aagcggcgac cgtgcgccag
     3961 gtcagggacc aactcgtcga gcggggactg gcggacgacg aggagatcga gcgccatctg
     4021 gcgagcgtcg ccgccggccg cctcgacctg gcgacctcgc ccatgatctc cgcatggggc
     4081 cgccgcccga gctgagcacg cgggcggcgg cgcggatcgg cggctaggcc gccgtgtcgt
     4141 aggtgtagta gcgggtgtgg tcgagcatgt ccgccggggt cacgttgttc cacggccgca
     4201 tcgtgtcgtg cagatcgacc acgtcccgcg tccccgccgc cggcagatac ggcgagcgcg
     4261 ggtgcctggc ctgccactgc gaccagagct tgtcgacgaa cgcgtggtgc atccagaaca
     4321 ccgggtcgtt gggcgaggcc cccgtcgcca tctggccgcc gacccagacg tggacgcggt
     4381 tgtgcagatt gaccccgcgc cagccctcca gatggttgcg gaagccgtcg gatgcgctgt
     4441 tccagggcgc catgtcgtac gtcgccatgg cgaggacgcc gtcgacctcg gctcgggtcg
     4501 gcagctgggc gacggcggcg ccgagcgcgc ggcgcagata agtgcggccg tccacacgga
     4561 cgttgaccgg ccagttggcc gcctcgaacg cgaacggacc gtccatcacc tggccgtcgc
     4621 ggctgcgccc ggtgccgccg aggaagtcgg ccgcccacag gctggcggcc ggggtgcggt
     4681 cgaccgtcca gtcccagtac ggcacggtga ccgacgcgtc gacggactgg agggcctgct
     4741 cgaactcgat gaggaatctg cggtgccacg gcaggaagga cggcgagcgg tggccgaccc
     4801 ggtcgccggt gtcggtgtcg ctcatgatga aggcgttgtg ggtacgcacg aaggtgtcgt
     4861 accgtccgtc gcgcttcagc tggagcagcg cgtcgatcag acggcgcttc tcggcggcgg
     4921 tgaggtccgc ctggttcttg cgaacggcca tggctgtgct cctggttggg ctggatacgg
     4981 gcggggcggc ggcgtgcgga tcagacgagg gggaccaggg cggcgccctg gagctcgacc
     5041 acggcggcac gcgcgacggc gcggggcgtg gcgaacgtct cgtagtggtt cacgacgctg
     5101 atccaggtgc cgtcggcgtt ccgcatcaca tgcagttctt ggccgtctat ccgcacggag
     5161 tagccgccgc cgtgatgcat gtgcccggcg ccgggcaggc cctgtatgcg gcgcccctgg
     5221 aagacctcgt cgaaggcctc gggcgcgtcg tgcgccgcgt ccgaggcggg gcgggtgctc
     5281 aggggggcgg cgtgggcgct gctcgcgagg gcgagtgcgg tgagggtgcc ggcggtgacg
     5341 ccgatggcct ggcggcgggt gggtcgggac ggttcggacg gtcgaggcat cgcaatcccc
     5401 agggtggtgc ggtcggttgg cgcgcacgcg agcaccggga aacagtcgac cggcctggtc
     5461 acggccgtgc tgcccggcga agctgtgcgc ctccatccct accggcaggg ggcggttcgc
     5521 aagaaggggc gggcaattgg ttggccgcta tgcggacatg tccagattcg aagtgcagtg
     5581 ttcaatgacg gggatcttgt cggcggggcc gcgtcagcgg gccgggcgtg aagattctcc
     5641 ctgaaatatg ccagtagcgt gaagatcttg ttgcgttgac gtgtcccatg tgtccggcct
     5701 cacgcggaaa aggtgaccgg aaacgcccgt ccgtcctccc gggtgcgggc gttggtgaac
     5761 acccccgacg cagggcgcta ccaggagcga tcgagggggc aaggcctggg tgtcggcgct
     5821 ctgtcgggcg ctgtcggcgc ggtgtcggtg gggctcggca ccgtgggaga ggtccggccg
     5881 ggtgcccacc cggccgcgct gtgaagggaa ctctcatgca tgacgtagtg atcgttgggg
     5941 ccggcccggt cggtctgttc ctcgcttgcg agctcggcct cgcgggctgt tcggtcctgg
     6001 tgctggagcg cgagccccaa ccccaatccc cgttcaaggc cgagccgttc gggatgaggg
     6061 gcctgtccgg ggcgtcggtc ggggccttct accgccgggg gctgttaccc caactgctgt
     6121 ccgcctccgg catgtccgag gatcccggcg ctcccaccgc ctcgcccctg cgcggggcgg
     6181 gccacttcgc gggcatgatg ctcgacccgg cccggatcga cgtcgactcg ctgccctatt
     6241 ggctgcccag cccggcgccg cggagtctgc ggacccacct cgaagcggtc gagacggtgc
     6301 tgtccgagcg ggcgtccggg ctcggggtgg acatccggta cggggtcgcg gtcacggacg
     6361 tgacccagaa cgagcggggc gcggtggccc acgccggcgg acacacgtat ccggcgcgct
     6421 ggctcgttgg ctgtgacggc ggacgcagca cggtgcgcaa gctcgccggc ttcccattcg
     6481 agggaaccga gccgcagttc accggctact cgatgcaggt caccgtcgcc gtcccggaga
     6541 agctggactt cggattccat ctgacgccgc agggcatgta cctccggctc ctgccgggac
     6601 acctcgccat gatggacttc gacggcggcg ccttcgaccg ctcgcggcag cccaccctcg
     6661 accacctcca gtcggtactg cgccgtgtct cgggcaccga tgtgacgctg agcgaggtcc
     6721 agctcgcgac caccttcacc gatcgggcca tgcaggcgac gacctaccgg caaggacgcg
     6781 tgctgctcgc gggggacgcc gcccacatcc actccccgct cggcgggcag ggactcaacc
     6841 tcggcatcgg cgacgccatg aacctgggct ggaagctcgc ggcgaccgtg cgcggacacg
     6901 cgccgcaggg gctcctcgac acctacaccc gcgagcgccg tcccgtcggc gcggcggtgc
     6961 tcgactggtc gcgcgcccag gtggcggtga tgcgaccggg cccgtacgcc caggcggtcc
     7021 agggcgtggt gcgcgatctg atcggcaccc gcgacgggac gacctatgtg ttcgagcgga
     7081 tatcgggagc gtggatccgc tacgacctgg gcggtgagca tccgctggtc ggccgggacg
     7141 cgccggacct ccacctggag gacggcagcc gcctgggcga cctgatgggc gacggtcgtg
     7201 gcgtggtgct cgacttcagt gccgagcaat ccctgcggcc cgcggcgaag aaccgggaga
     7261 gccggctgcg gtacgtggcc ggcgcggccc ggaacgacct cgggctcggc gccgtgctgg
     7321 tccggcccga cggcgtggtc gtctgggcgg acggtcgcac accggaccgc ccggcgttcg
     7381 aggcggccgt cagcgagtgg ttcggcgacc cggagagctg atgagcagtc aggagccttg
     7441 gcgcgccggc cgccttcaac tgccttgttc ctggccctat ttcggccacc ctctcgcggt
     7501 tccttgccgg aaggcgggcc ggccgggggc caccccggcc ggcccagccg tcagcccacg
     7561 ccgcggggca gcacgagcga ctggatctcg gggagggcgt tccagtcgtt cgaggccaca
     7621 ctggcgtggg cggcggcgag ccgggccacc cgggcccggg cgtccgccgg tgacgggttc
     7681 ttgtcgtcga gggccggcgc cacgttctgg gcgtcggtca tgaccaggaa atagtggtgg
     7741 gtgtcgtacc aggcggtgtc gaccgtgccg ttcagatacg tcgccgcgtc gccgtcgaag
     7801 accacgaacc acgggcggat cgaggcatcg gcgtatcgtg aacgggggtc ccccgcctgg
     7861 gcgttgtgga cggcggggaa gacctgggcc cgcgccgtac ggcccgccgc cgcgaggtcg
     7921 cgcagatggc gcgcgtactc gacgtccgtc cacagcgtgt cggtggggtt gccctcctcg
     7981 accgtgccgg ggatcacttc gagcatcacc ttgcccgcga gtgcctcacg gctcggccag
     8041 ttgcccgcgt tcgccgcctc gtcgagcgtg gcgtactgac cgccgcccgg cttggcgagc
     8101 agatcggccg ggcggaagac cgccgggccc agatggtcgg cgatcgtctg gtcgagcttg
     8161 tcgggaccca tgccgtacgt ggcctggaac ccggccttca tctccagctt gacgacgagc
     8221 ggcggatggc cggggtgggc ggagagccag acgcgtatgt cgtccagaca gctctccagg
     8281 ttcttgttcg caccgccggt gtagagctgg gcgggggtgg tggcgttgac gcagttgttg
     8341 ctgttgccca gcgggttgga gtggctgacc ttccactcct tggtgatgaa gtcgtcccac
     8401 acgtcgagct cgatcatcga ggtgccggtg tcgagggccc gggccagata ggggaaggcg
     8461 gccgggtcgt aggtgttgtg cagtccggag acggtggccc cggacagggg cagggtctcg
     8521 ggccccgccg cggacgcgct gccgccggcg cccgccgagg cgagggcgag gcaagcggcg
     8581 agcgcgccga gcagggtggt gcgcggccgg ggggtgaatc gtctgggccg gggatccgac
     8641 acgggtcctc ctaggggggt gacactccgt caggacgctg tcatcgccga gtgaagcgac
     8701 gaagacatgt caagtaacac gaggtggatt cctcctgtca ccccccgcgg ccggatcggc
     8761 cgcgcgtgat gccggtgcgc tcgcccttca ggcgaacccg gcacggtgga cggcgcgttg
     8821 aggccgtccc ggcgggagcc gcctagaagt tgaagacagc ctcggaaccg gcggccttca
     8881 tgcaggagtt ggcgtaggtc tgtacgtagt tgatccgctg gccgttccac acgccgtccg
     8941 cccggacggt gaccggctgc cagatcttcg tacacagacg ggggcctccg ctcgcggcga
     9001 gagcactgaa gttgccctgg acgccgcgga gttcggcaca cgcggcggcg ggtgccgggt
     9061 gggtgccgga gggggtgggg gtgcagttga gggtgaccgc gcgctgcacg gaggcaccct
     9121 cgttgccggt tccgggctcg acgctgatca ccagcgccga cggcgggtag aggctcatcg
     9181 gcttcatcgc gccggccggg gccgcggtcg cactgccgag cccggtgccg acgagaccgt
     9241 tcgccaacag ggcgacggtg acggcactga ctgctgcgat cttccgcatt tcgaacactc
     9301 ctggggttgg attccggaga acgaacagga gtctctaccg ctctgaacct ctccgcgcaa
     9361 cgaaccggac acattcggtc acatgtagtc acgtaccgaa gccgtgtcgg cgcaggcggg
     9421 cgcatggaca cgcaggtcgc cgcgcccgcc aaggtcggcc aaaagaaagg catgatgtcg
     9481 ggtgtgaggt cgaattcaag gcaatcgcaa aacgaattct gggaatctta ggccgaattg
     9541 aggactggtc agttcgcgcg gactcggcgg ggcacccgga gcgggtcccg ggattcgatc
     9601 ttcgcggggc taggatcccg gcatggagct tcgacagctg cggtacttcg tcgccgtggt
     9661 ggaggaggcc aacttcaccc gggccgcggc ccgtctgcat gtggcccagc ccggcgtcag
     9721 cgcgcagatc cgccagttgg agcgcgagct cggccagcgc ctgctcgacc gcgccggcgg
     9781 ctcgatcacc cccaccgagg cgggcgaggc ggtactgccg cacgcgcggg ccgcgctcgc
     9841 cgccgtcgag gcggtgcgcg acaccgtgga cgagttcagc ggactgctgc gcggacacgt
     9901 cacgatcggc gtggtctccg gcgccgtcac ccaggacttc gacatcgcac tggcgctcgc
     9961 cgacttccac gacgcccacc ccgaggtcga gatcacgctc accgaggaca cctcggaccg
    10021 gatgcgggcg gcgctgctcg cgggccggct cgacatcgcc ctgatcggcc tcgcgcacga
    10081 ggcgctcccg gtgggcctct cgctcgacgt ggtggtcgac gagcccctgg tggcggccgt
    10141 cgccgagggc gaccccctgc tcacccccgg ccgcaccgag gtcacgctcg ccgaactggc
    10201 gagccgcccg ctcatcggcc tgccgcgcgg cagcgggatc cgcgcggtcc tcgacggggc
    10261 ctgcgcgcag gccggaatcc gcccgcgcgt cgccttcgag gccgcctcgc cccagctcct
    10321 ggcccggctc gccgcgcgcg gcctcggcgt ggccgtcctt cccgcacccg gcgccgacgc
    10381 cccgccgggc
//
