LOCUS       NZ_CP032698            21074 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7415181
            Orig. end                         :: 7436255
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="31"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(393..1685)
                     /gene="paaK"
                     /locus_tag="DWB77_RS32995"
                     /old_locus_tag="DWB77_06658"
     CDS             complement(393..1685)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (81-332). E-value: 3.4e-24.
                     Score: 77.1. Matches aSDomain:
                     nrpspksdomains_DWB77_RS32995_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060733.1"
                     /locus_tag="DWB77_RS32995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06658"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_120725854.1"
                     /sec_met_domain="AMP-binding (E-value: 4e-27, bitscore:
                     93.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAELDEAERLSRPELQALQLERLRASLRHAYDNVAFYREAFDKA
                     GVRPQDCHSLADLARFPFTAKSDLRDHYPFGMFAVPESEIRRIHASSGTTGRPTVVGYT
                     QRDLDTWADVVARSIRAAGGRPGHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGM
                     TARQVQLIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRSTSLEVGIFGAEPWTEEMRRE
                     IEERFAIDAVDIYGLSEVMGPGVAQECVETKDGLHIWEDHFYPEIVDPLTGEVLPDGER
                     GELVFTSLTKEAMPVIRYRTRDLTRLLPGTARIFRRMEKVTGRSDDLIILRGVNLFPTQ
                     VEEIVLRTPGVAPHFQLRLTRQGRLDALTVRVEARAGLAPEQREAAARSIVAAVKDGIG
                     VSVEVEVVDPETIERSVGKFKRIVDLRQERS"
     aSDomain        complement(690..1442)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS32995_AMP-binding.1"
                     /evalue="3.40E-24"
                     /label="DWB77_RS32995_AMP-binding.1"
                     /locus_tag="DWB77_RS32995"
                     /protein_end="332"
                     /protein_start="81"
                     /score="77.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ESEIRRIHASSGTTGRPTVVGYTQRDLDTWADVVARSIRAAGGRP
                     GHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDFRPEIIMVTPSY
                     MLTLLDEFERQGVDPRSTSLEVGIFGAEPWTEEMRREIEERFAIDAVDIYGLSEVMGPG
                     VAQECVETKDGLHIWEDHFYPEIVDPLTGEVLPDGERGELVFTSLTKEAMPVIRYRTRD
                     LTRLLPGTARIFRRMEKVTGRSDDLIILR"
     misc_feature    complement(1684..1698)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    1685..1699
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            1905..3419
                     /locus_tag="DWB77_RS33000"
                     /old_locus_tag="DWB77_06659"
     CDS             1905..3419
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-264). E-value:
                     5.8e-30. Score: 96.6. Matches aSDomain:
                     nrpspksdomains_DWB77_RS33000_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060732.1"
                     /locus_tag="DWB77_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06659"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_120725855.1"
                     /sec_met_domain="PF00561 (E-value: 6.9e-26, bitscore: 90.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.9e-18, bitscore:
                     65.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKFTTYDGTRLAYHLRGTGEPLLCVPGGAMRASQYLGELGGLAA
                     HRRLVLLDLRGTGDSEIPDDPSSYRCDRQVADIEALRAHLGLDRIDLLGHSAGSNLAML
                     YAAAHPDRVARLALITPTPWALGMPPTPEERLAAARLRKDEPWFEEAYAAYAAELAGQP
                     PQAEYEALLYGRWDAAAKAHADAAERQCNDAAADVFWSDGAFDPAATRAAMAQLDAPVL
                     VLAGEWDGGPCPELAARAAACFADGQLQVQPSSGHFPWLDDPGAFTRTVAAFLDPDVRT
                     VTVDGVRLAYRVRGDEWAPPVVLVHGRGGDSRDWEVIAERLAATRRVYALDLRGHGLSD
                     WPGGYSFEAFRDDLRGFLTQLGLNGADLVAHSMGGAAAALLAEDEPGFIGRLVLEETPP
                     LFPLKPPRGPMERPAGELGFDWAVVPAIDAQLNDPDPSWRGRFAAIAVPTLVVAGGPTS
                     HVDQKKVAWMASRIPDARLVTIDAGHLVHTERPAAFLDALDAFGIK"
     aSDomain        1968..2696
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS33000_Abhydrolase_1.1"
                     /evalue="5.80E-30"
                     /label="DWB77_RS33000_Abhydrolase_1.1"
                     /locus_tag="DWB77_RS33000"
                     /protein_end="264"
                     /protein_start="21"
                     /score="96.6"
                     /tool="antismash"
                     /translation="PLLCVPGGAMRASQYLGELGGLAAHRRLVLLDLRGTGDSEIPDDP
                     SSYRCDRQVADIEALRAHLGLDRIDLLGHSAGSNLAMLYAAAHPDRVARLALITPTPWA
                     LGMPPTPEERLAAARLRKDEPWFEEAYAAYAAELAGQPPQAEYEALLYGRWDAAAKAHA
                     DAAERQCNDAAADVFWSDGAFDPAATRAAMAQLDAPVLVLAGEWDGGPCPELAARAAAC
                     FADGQLQVQPSSGHFPWLDDP"
     CDS_motif       2178..2222
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS33000_0001"
                     /evalue="1.70E-03"
                     /label="NRPS-te1"
                     /locus_tag="DWB77_RS33000"
                     /protein_end="106"
                     /protein_start="91"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LLGHSAGSNLAMLYA"
     gene            complement(3412..5142)
                     /locus_tag="DWB77_RS33005"
                     /old_locus_tag="DWB77_06660"
     CDS             complement(3412..5142)
                     /NRPS_PKS="Domain: AMP-binding (8-466). E-value: 3.7e-66.
                     Score: 215.3. Matches aSDomain:
                     nrpspksdomains_DWB77_RS33005_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530284.1"
                     /locus_tag="DWB77_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06660"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_120728508.1"
                     /sec_met_domain="AMP-binding (E-value: 9.2e-69, bitscore:
                     230.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALVYLDHPGTGAERRLTYRQLDTAA
                     NRLAHHLIDAGLKPGEHLGLHLYNGVEYLQTVLAALKARLVPVNVNYRYVEEELAYLYQ
                     DADLAALVFDTEFSPRVAGALTQARKLRHLIRVGAAEGGAGAVEDGVGSAEGGAGSAEG
                     GAGSAEGGARVAGAVAFTEAEASGSPERGFGPRSGDDLFIIYTGGTTGLPKGVMWRQED
                     LFFAGLFGGDPAGEPVKRPEELAERVAKGGAGLTFFPAPPLMHGTSTLTSFVAFDYGQR
                     VVIHRKYVPEEVLRTIEKEKVTSVSLVGDAMLRPLIDALHGPLKGTDLSSLFSVSSSGA
                     IMSQTVRDQLQELVPGALILNNFGSSESGSNGKATDDSGPEKGFRLEVNDRTRVVDPVT
                     HEMVAVGEPGRLAQRGHVPLGYYNDPVKTAETFFQRGTERWVLLGDMATVDEDGIVTVL
                     GRGSQCINTGGEKVYPEEVEQALKSHPDVYDALVAGVPDPTWGSHVAAVVQVRAGAARP
                     TLETIQTHCRTRLAGYKVPRQLVIAPAIQRSPSGKADYRWARSVACEADTEEGGGAALT
                     "
     aSDomain        complement(3745..5118)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS33005_AMP-binding.1"
                     /evalue="3.70E-66"
                     /label="DWB77_RS33005_AMP-binding.1"
                     /locus_tag="DWB77_RS33005"
                     /protein_end="466"
                     /protein_start="8"
                     /score="215.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALVYLDHPGTGAERRLTYRQLDTAANRLAHHLI
                     DAGLKPGEHLGLHLYNGVEYLQTVLAALKARLVPVNVNYRYVEEELAYLYQDADLAALV
                     FDTEFSPRVAGALTQARKLRHLIRVGAAEGGAGAVEDGVGSAEGGAGSAEGGAGSAEGG
                     ARVAGAVAFTEAEASGSPERGFGPRSGDDLFIIYTGGTTGLPKGVMWRQEDLFFAGLFG
                     GDPAGEPVKRPEELAERVAKGGAGLTFFPAPPLMHGTSTLTSFVAFDYGQRVVIHRKYV
                     PEEVLRTIEKEKVTSVSLVGDAMLRPLIDALHGPLKGTDLSSLFSVSSSGAIMSQTVRD
                     QLQELVPGALILNNFGSSESGSNGKATDDSGPEKGFRLEVNDRTRVVDPVTHEMVAVGE
                     PGRLAQRGHVPLGYYNDPVKTAETFFQRGTERWVLLGDMATVDEDGIVTVLGRGSQCIN
                     "
     CDS_motif       complement(3847..3894)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS33005_0002"
                     /evalue="3.90E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="DWB77_RS33005"
                     /protein_end="432"
                     /protein_start="416"
                     /score="12.9"
                     /tool="antismash"
                     /translation="VPLGYYNDPVKTAETF"
     CDS_motif       complement(4489..4539)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS33005_0001"
                     /evalue="5.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="DWB77_RS33005"
                     /protein_end="218"
                     /protein_start="201"
                     /score="19.0"
                     /tool="antismash"
                     /translation="FIIYTGGTTGLPKGVMW"
     misc_feature    complement(5233..5247)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.63"
                     /tool="antismash"
     misc_feature    complement(5235..5251)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(5237..5252)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     gene            5307..6107
                     /locus_tag="DWB77_RS33010"
                     /old_locus_tag="DWB77_06661"
     CDS             5307..6107
                     /NRPS_PKS="Domain: ECH (9-257). E-value: 1.2e-51. Score:
                     167.3. Matches aSDomain:
                     nrpspksdomains_DWB77_RS33010_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="DWB77_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06661"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_120725856.1"
                     /transl_table=11
                     /translation="MGGTEHLTVQREGATLVLTLNRPEAKNALSLPLLVGLYDGWLEAD
                     ADDSIRSIVLTGAGGDFCAGMDLKALAGGGMAGDHYRDRLTADPDLHWKAMLRHHRPRK
                     PVIAAVEGYCVAGGTEILQGTDIRVAGAGATFGLFEVKRGLFPIGGSTVRLQRQIPRTH
                     ALEMLLTGRPYSAEEAVRIGLIGRVVPDGTALDVALRIASEINACGPLAVEAVKECVYA
                     TASMGEAEGLALELERGWPVFATEDAKEGAAAFAAKRVPVFRRG"
     aSDomain        5334..6077
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS33010_ECH.1"
                     /evalue="1.20E-51"
                     /label="DWB77_RS33010_ECH.1"
                     /locus_tag="DWB77_RS33010"
                     /protein_end="257"
                     /protein_start="9"
                     /score="167.3"
                     /tool="antismash"
                     /translation="QREGATLVLTLNRPEAKNALSLPLLVGLYDGWLEADADDSIRSIV
                     LTGAGGDFCAGMDLKALAGGGMAGDHYRDRLTADPDLHWKAMLRHHRPRKPVIAAVEGY
                     CVAGGTEILQGTDIRVAGAGATFGLFEVKRGLFPIGGSTVRLQRQIPRTHALEMLLTGR
                     PYSAEEAVRIGLIGRVVPDGTALDVALRIASEINACGPLAVEAVKECVYATASMGEAEG
                     LALELERGWPVFATEDAKEGAAAFAA"
     gene            6362..7321
                     /locus_tag="DWB77_RS33015"
                     /old_locus_tag="DWB77_06662"
     CDS             6362..7321
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379352.1"
                     /locus_tag="DWB77_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06662"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_120725858.1"
                     /transl_table=11
                     /translation="MAGSAATEVLRAPLVVEFPFTRSLGPVQSAFLTGLRERVVLGVRT
                     GDGRVLVPPVEYDPVTAEEIRELVEVAPAGTVTTWAWNPAPRRGQPLERPFAWVLVKLD
                     GADTSLLHALDAPGPDAVHSGMRVRVRWAQDRTGAITDIACFEPDDGGEEAQPCGHSGE
                     FEDAVTGIVAPARLDYTYSPGRAQSAYINALSARKTVGERCPDCRKVYVPPRGACPTCG
                     VATEERVEVGPAGTVTTYCIVNIKAKNLDIEVPYVYAHIALDGAGLALHGRIGGIPYDQ
                     VRMGLRVEPVWSEGGRYPDHYRPTGEPDADYETYKELI"
     misc_feature    6405..6422
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.68"
                     /tool="antismash"
     gene            7321..8382
                     /locus_tag="DWB77_RS33020"
                     /old_locus_tag="DWB77_06663"
     CDS             7321..8382
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884001.1"
                     /locus_tag="DWB77_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06663"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_120725860.1"
                     /transl_table=11
                     /translation="MAPTGPGRDVAIVAFAQSDHRRRTDELSEVELLMPVLHQVLDATG
                     LKTSDIGFTCSGSSDYLAGRAFSFTMALDGVGAWPPISESHVEMDGAWALYEAWVKILT
                     GEADTALVYGYGKSSPGEVRDVLTRQLDPYYVAPLWPDSVSLAALQAQALIDAGDTDET
                     ALASIAGRSRAAATANSHAQVRGSRAQGEYVVRPLRTGDCPPIGDGAAAVILAAGDRAR
                     DLCARPAWIRGMDHRIEAHSLGVRDLTDSPSTRLAAERAGFFERPVDTAELHAPFTSQE
                     VVLRKALRLGEDVSVNPSGGALAANPVMAAGLLRLGEAAARIHRGDSDRALAHATSGPC
                     LQQNLVAVLEGES"
     gene            8379..9545
                     /locus_tag="DWB77_RS33025"
                     /old_locus_tag="DWB77_06664"
     CDS             8379..9545
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057880.1"
                     /locus_tag="DWB77_RS33025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06664"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_120725862.1"
                     /transl_table=11
                     /translation="MSKEPVAVVGVGQTKHVAARHDVSIAGLVREAAQRALEDAELTWA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVASNLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFTQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHLHEHDITLEKVQASPMLWDPIRYSETCPSSDGACAMVLTDRA
                     GAARSPRPAAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQAGIADPRREIDAVE
                     MYVPFSWYEPMWLENLGFAAEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGLAGEHQVAGARKALGHAYGGGSQFFAMWLVGAEPPAR"
     gene            9686..9922
                     /locus_tag="DWB77_RS33030"
                     /old_locus_tag="DWB77_06665"
     CDS             9686..9922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019883999.1"
                     /locus_tag="DWB77_RS33030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06665"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_120728510.1"
                     /transl_table=11
                     /translation="MGTLAGHTRSGWEKPELDLSKAEWRSSSQGAGDVQIAFVEGFIAM
                     RNSASPGSPPLIFSPAEWRAFVINARDGEFDLT"
     gene            complement(10001..11074)
                     /locus_tag="DWB77_RS33035"
                     /old_locus_tag="DWB77_06666"
     CDS             complement(10001..11074)
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041624.1"
                     /locus_tag="DWB77_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06666"
                     /product="isoafricanol synthase"
                     /protein_id="WP_120725864.1"
                     /sec_met_domain="T1TS (E-value: 7.9e-86, bitscore: 287.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSTGRVRSARTRTGLVDIPFPARRHPRHELARRHTLDWLYEFGM
                     LAGEQATAEYDAMGLERLMAYFYPDASDAHLALATDLNAWFFVFDDQFDGPLGKRPDVV
                     VRQIDTVLRTMSDEPPVPGEATNRLAESFRDLWQRVTAGTPLLWQDRFRAHWREYLTAY
                     HWEALNRTRNGTLTLPLFLRGRRDSIGVQPCLDLVERCGGYTLPRELHEGAPLAEMRVI
                     TADVVIFVNDMVSVDKELAAGDVNNSVIILLRQEMCSVDQAVRRVAAMANSRIARFQEL
                     TVELAAQLDTTELPERVRAQVDDYVDGMRALMSGNLAWSLETARYGEAGIAAVSEGRQR
                     PWAQLFPEQASGEREGA"
     misc_feature    complement(10316..10318)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11335..14193
                     /locus_tag="DWB77_RS33040"
                     /old_locus_tag="DWB77_06667"
     CDS             11335..14193
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173679.1"
                     /locus_tag="DWB77_RS33040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06667"
                     /product="AAA family ATPase"
                     /protein_id="WP_281280099.1"
                     /transl_table=11
                     /translation="MWRRREVGAERRAGEGSAANGGLLAIAGSAGLGKTTLVAEVRRKA
                     AARGCTLLAARGSEQEEGVAFHVVRQLVQPVLAATSEAEHRKILGSWYDIVAPAVGLVA
                     GQSGVSPDPQGVRDGLDWLVTRFAVQYAPVVLVVDDAHWADEETLAWLSSFALRAGDLP
                     LLIVVAYRPEELPRHAAEFRRLAMRHGSRPLDLSPFTPAAVSDLVRGVLGDGGDELFAR
                     ECWALTAGNPYEAVELVARIRDRGIKPQYANAGELRELASAVRGSGLIERLERLGPSAV
                     RLTWAVAVLGTDADREMAAGVAGLGAEEMADAVERLRDARILAGPTEGSNRLDFFHPLV
                     GTAVYRAIPAAMRVAMHGQAAFAVTEAGLGATAAARHILEMHPDNDRWAVRQLRSAARD
                     YLRAGAPDAARRCLSRALREPPALEERAEVLYELGCSALLNEPATTVNHLRAALEEPEL
                     APELRESVTYRLAQALAHTDRMAEAAALVAAEAKHSSNARTRLRMQAETFQWNAFRADE
                     EDSPTRSRSLARLAEHLTVRGKAERYILGLRAWDAMVRGEPAETALRYAEEALEGGLPW
                     TDDNWGFEVPVLVALTFMYCDQPGRADELFTQGIADCERKGWRGAHLSFGLTLLGYIKF
                     HRGRLAEAEDLVHSGLRIADRVGQQIPAQWFALGILIEILLARGRVQEAQELSDAYNYG
                     QVVPNAVVYPDSETVYSELLLARGLRTDAEERLRAVGRRLEPRGMRNPMWCPWRPLLAQ
                     TIAHTDPGEAAEIAQEGVEIARRFGTPGAIGRALHAAAKVASGADSLSLMSEAVRQLER
                     SPAAYELAQALIDHGAMLSRAGLPQDAADLLMRGLESAALCGADALAARAREELAASGL
                     RPLQLRAVDSDSLTSQEKAVAERAAQGWENRRIAEDLGIKERTVELLLSGAFRKLGTDR
                     GGLAGLLPHQTRGSGVRGVPGP"
     misc_feature    complement(11378..11392)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            14325..14825
                     /locus_tag="DWB77_RS33045"
                     /old_locus_tag="DWB77_06668"
     CDS             14325..14825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="DWB77_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06668"
                     /product="hypothetical protein"
                     /protein_id="WP_120725868.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPAREMAEGQVPFEVAQLLVALENDESIEVVGSEDM
                     PVMQGDNLLIVRRLKLSESRISCVQFDRSDNVLVTIASWDRPITDDLYALLKPLPAELF
                     QQG"
     misc_feature    14998..15013
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.76"
                     /tool="antismash"
     gene            15139..16467
                     /locus_tag="DWB77_RS33050"
                     /old_locus_tag="DWB77_06669"
     CDS             15139..16467
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102934.1"
                     /locus_tag="DWB77_RS33050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06669"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_120725870.1"
                     /transl_table=11
                     /translation="MTSKQRIRLALAAATAGALGLALAPASPASAAGPDTECPRTLTCD
                     WVPAAYQQTGDPADKKTYGNYDVSDRPGTNKIKYIVLHDTEETFATTLKIFQDPKRAAS
                     AHYVVRSSDGHVTQMVKTKDVAWQAGNWYINSDSIGIEQEGYATAGAAWYTPEMYRSTA
                     ALVRYLAAKYDIPLDRQHILGHDNVPPTTAAGTAGMHWDPGPYWDWNHFMSLLGRPTQQ
                     TGRPGGQLVTVDPVFKKNLQAFRDCEKNVDLPAAPSSAVPLYTQPSTDAPLFADPGLHP
                     PGTPGTNCANDWGSKISAAQQAVVAERRPGWTAIWWYGQEAWFQSPAHTRTTTPTAGYV
                     VRPKPGLTDVPVYGTAYPAAGDYPGDFTAPRVSTPLAYTIKAGQSYPGGAPTPSGYFYA
                     PTIDSSYPYDHTYFPGSIRYVTVQIGHRIAFVKASDVDVVRAR"
     gene            complement(16541..17671)
                     /locus_tag="DWB77_RS33055"
                     /old_locus_tag="DWB77_06670"
     CDS             complement(16541..17671)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="DWB77_RS33055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06670"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_120725871.1"
                     /sec_met_domain="APH (E-value: 1.8e-16, bitscore: 59.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSTPPRPHRPLGAGGGPYLDPTHAGSAYGASRMPRRSG
                     TGTQPLSGRIDLSGPQGAQLRIAIASVQRICPEFNPVQVLRHSGRSVLIVGTTGRTTAV
                     AKCLLDHSPAWAERFRHEIAAYRAFVRHRPPVRVPRLIAADPDNCTLVIERMPGRAAAL
                     TRHPVEAPPRADVRAALGAIARVNAWRPPAEMFGRPLDYAPRISRYHELGLFTDRDLSD
                     LQKLVHGLALSGRVDWQFSHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWAVL
                     GEAPMERRRISQAAQLAGPASRDAFLVNLMLVLTREIRTYETAVQRTMRDAAPASAAQN
                     PPGVPSAGEQQRLLLRRLHDDCALARRAVRAAVGTR"
     misc_feature    complement(17348..17350)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17726..17740)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            17905..19398
                     /locus_tag="DWB77_RS33060"
                     /old_locus_tag="DWB77_06671"
     CDS             17905..19398
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524494.1"
                     /locus_tag="DWB77_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06671"
                     /product="hypothetical protein"
                     /protein_id="WP_120725873.1"
                     /transl_table=11
                     /translation="MSGQPNTRLNDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGETPRDPVPRVLAALFTERLGRVVTIEDLGFDRHGRAGKRNDVRNPKNPDGV
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALATGSVLSSAMHDWLHTDPVLSADAPR
                     LHDPLHADPAGFDRYEAAPIGSQEIDALERSVDVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDIGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPGEALDLMKLAKSGSGEETLPRTRAMLHTIEAWAQASLGRGQA
                     MRRTLGEAEELFVSDKGDVPPPSWMQMFDEADLHGMQALAFRTLAEHDPAAATIAQHHA
                     KQALELRVGGRQRSKIFDYISLASACFIADDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTSQYAGYGKIQDLREEIQLALPQAPVKRSRVADI"
     gene            complement(19488..20921)
                     /locus_tag="DWB77_RS33065"
                     /old_locus_tag="DWB77_06672"
     CDS             complement(19488..20921)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474388.1"
                     /locus_tag="DWB77_RS33065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_06672"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_120725875.1"
                     /transl_table=11
                     /translation="MPSHLFADRPAPQPPERGTVDALITQTRRLRGGVDAVRRDAFVDD
                     DDAQARWQRALCDLAVHQLDDLGAHLDQLRDGPTAEEQDATTLAVESSFGNGPDAPGPL
                     SRVGSAEWNLLTDAVSWSEELFQIFGRSPESGGMSLDELPTMVVDEDQALLTTMVTGAL
                     VDGRPIDGEFRIVRPDSTITTLHMMGEPVLDADGCTASMWAVLRDVSELRRSQRAVRES
                     RDRLQRQRRIARTEHRLAVELQEAVLPPWRGSLRLPHGGPGALDIAAHYLPSSASDLIG
                     GGWYDALELPGGASLLTVGDLTGHGVTATGGMAMLLGALRGMAVAGIGPGPLMGHLNQL
                     LETTVQPALGSAVCCRYEPARRRLVWSGAGHPAPLLFRGGTGRALGASGGVLLGATHGA
                     AYDQAEATLHAGDLLVLHTDGLTRRAACDDGDQRRLLALAPLFDGGRTAQDCVRMIVEE
                     FGEHEREDDACVLVARIGS"
     misc_feature    complement(20034..20036)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gcggtgcgcg acgccgaggg ctacttcacc gtcgtcgacc gggtgaagga cgtcatcaac
       61 tccggcggcg tactgatcgc ctcgcgccag gtcgaggacg tgctgtacac gcatccggcc
      121 gtcgccgagg ccgccgtggt ggggctgccc gacgagcgct ggatcgaggc ggtcaccgcg
      181 ttcgtcgtac ggcggggcga ggtgagcgag gccgcactca tcgaccacgc ccgccggtca
      241 ctggccggct tcaagacccc caaacgggtg cggttcgtgg acgaactgcc ccggaacgcc
      301 agcggaaaga tcctcaagcg cgaactgcgc cggttcgcct gaacacccgg gcgaggcaag
      361 ggagttgagg tctccggagg tccccacctc tgtcaactcc tctcctgccg caggtcgacg
      421 atgcgtttga acttgcccac cgaacgctcg atggtctcgg ggtcgacgac ctccacctcc
      481 accgagaccc cgatgccgtc cttgaccgcc gcgacgatcg agcgggcagc cgcctcgcgc
      541 tgctccggcg ccaggcccgc ccgcgcctcc acccgtaccg tcagcgcgtc gagccggccc
      601 tgccgggtca gcctgagctg gaagtgcggg gcgacgccgg gcgtgcgcag cacgatctcc
      661 tcgacctggg tggggaagag attcaccccg cgcagaatga tcaggtcgtc gctgcgcccg
      721 gtcaccttct ccatccgccg aaagatccgg gccgtgccgg gcagaagccg cgtcaagtcc
      781 cgcgtccggt aacggatcac cggcatcgct tccttggtga gcgaggtgaa gaccagctcg
      841 ccccgctctc cgtccggcag cacctcaccg gtgagcggat ccacgatctc cggatagaag
      901 tggtcctccc agatgtgcag cccgtccttg gtctccacgc attcctgcgc gacaccgggg
      961 cccatcacct cggagagccc gtagatgtcg accgcgtcga tcgcgaaccg ctcctcgatc
     1021 tcgcggcgca tctcctcggt ccacggctcg gcgccgaaga tgccgacctc gagcgaggtg
     1081 gagcgcggat cgacgccctg ccgctcgaat tcgtcgagca gcgtcagcat gtaggacggc
     1141 gtcaccatga tgatctcggg gcggaagtcc tggatgagct gcacctgacg ggccgtcatg
     1201 ccgccggagg cggggatcac cgtgcagccc agtcgctcgg ccccgtagtg cgcgccgagc
     1261 ccgccggtga acaggccgta tccgtacgcc acatgcacct tgtggccggg gcgtccgccc
     1321 gcggcgcgga tcgaccgggc caccacgtcc gcccaggtgt ccaggtcacg ctgggtgtag
     1381 ccgacgacgg tcggccggcc cgtggtgccg ctggaggcgt ggatgcggcg gatctcgctc
     1441 tcggggaccg cgaacatccc gaacgggtag tggtcgcgca gatccgactt cgcggtgaag
     1501 gggaagcggg ccagatcggc gagcgagtga cagtcctgtg ggcggacccc cgccttgtcg
     1561 aaggcctccc ggtagaacgc cacgttgtcg taggcatggc gcagcgaggc ccgcagccgc
     1621 tcgagctgaa gggcctggag ctccggccgg ctcagccgct cggcctcgtc cagctcagct
     1681 gccatgggtg cgctcccgtc ctcgccccac ccgcgaaggg tgacgaaatc ggacgaccga
     1741 tcattcggtc gatctgttcc cggatcagta attcaccagc cccaggggtg cgtcaaggcc
     1801 tgtggacaac ccgcgacgaa ccctcggacc gatcgccggt ccaagatcgc gccgtgagcg
     1861 aaaggcgttg ccgcgcccgg cggacggctg tgaggatcgc agtcatgccg aagttcacga
     1921 cgtacgacgg aacccgactc gcctaccatc tgcgaggcac gggcgaaccc ctgctctgcg
     1981 tgccgggcgg cgcgatgcgc gcctcgcagt acctcggaga gctgggcggc ctcgccgccc
     2041 accgccggct ggtcctgctc gatctgcgcg gcacgggcga ctcggagata ccggacgacc
     2101 cctcgtccta ccgctgcgac cggcaggtgg ccgacatcga ggcgctccgc gcccacctgg
     2161 gcctcgaccg gatcgatctg ctcggccact cggcgggcag caacctggcg atgctgtacg
     2221 cggccgccca ccccgaccgg gttgcccgcc tcgcgctgat caccccgacc ccctgggccc
     2281 tcggtatgcc gccgacgccc gaggagcggc tcgccgcggc ccggctgcgc aaggacgagc
     2341 cgtggttcga ggaggcgtac gcggcctacg cggcggagct cgccgggcag ccgccgcagg
     2401 cggagtacga ggcgctcctc tacggccggt gggacgcggc ggccaaggcg cacgcggacg
     2461 ccgctgagcg gcagtgcaac gacgcggcgg cggacgtctt ctggagcgac ggcgccttcg
     2521 accccgcggc cacccgtgcc gccatggccc aactcgacgc cccggtcctc gtgctggccg
     2581 gtgagtggga cggcggcccc tgcccggagc tggcggccag ggccgcggcc tgcttcgccg
     2641 acggacagct ccaagtccag ccgtcttccg gtcacttccc ctggctcgac gacccgggcg
     2701 ccttcacccg taccgtggcc gccttcctcg acccggacgt ccgcacggtc accgtcgacg
     2761 gggtgcggct cgcctaccgc gtccggggtg acgagtgggc gccgcccgtg gtcctcgtgc
     2821 acggccgggg cggcgacagc cgggactggg aggtgatcgc cgaacggctc gcggccaccc
     2881 gccgggtgta cgccctcgac ctgcgcggcc acggcctgag cgactggccg ggcggctact
     2941 ccttcgaggc tttccgcgac gacctccgtg gcttcctcac ccaactcggc ctgaacgggg
     3001 ctgacttggt ggctcattcc atgggcggcg cggccgcggc gctgctcgcc gaggacgagc
     3061 ccggcttcat cggccgtctc gtcctggagg agaccccgcc gctcttcccc ctgaagccgc
     3121 cgcgcggtcc catggagcgc cccgccggtg agctcggctt cgactgggcc gtggtgcccg
     3181 cgatcgacgc ccagttgaac gaccccgacc cgtcgtggcg cggccggttc gccgccatcg
     3241 cggtccccac cctggtcgtg gcgggcggcc cgaccagcca tgtcgaccag aagaaggtgg
     3301 cctggatggc ctcgcgcata ccggacgccc gcctcgtcac catcgacgcg ggccatctcg
     3361 tgcacaccga gcggcccgcc gccttcctgg acgcgctcga cgcgttcggc atcaagtgag
     3421 cgccgctccg cccccttctt cggtgtccgc ctcacaggcg accgaccgcg cccagcggta
     3481 gtccgccttc ccgctcggtg agcgctggat ggcgggggcg atcaccagtt ggcgcggcac
     3541 cttgtaaccg gccagccggg tgcggcagtg cgtctggatc gtttcgagcg tgggccgcgc
     3601 cgcaccggca cggacctgga ccactgccgc cacatggctg ccccaggtgg ggtcgggcac
     3661 cccggccacc agcgcgtcgt acacgtccgg atgcgacttg agggcctgct cgacctcctc
     3721 cgggtagacc ttctcgccgc cggtgttgat gcactgcgag ccgcgcccga ggaccgtgac
     3781 gatgccgtcc tcgtccacgg tcgccatgtc gccgagcagc acccagcgtt cggtgccccg
     3841 ctggaagaag gtctcggcgg tcttcaccgg gtcgttgtag tagccgagcg gcacatgtcc
     3901 gcgctgggcc agccgccccg gctcgccgac cgccaccatc tcgtgcgtca ccggatccac
     3961 cacccgggta cggtcgttga cctccagacg gaagcccttc tccggacccg agtcgtcggt
     4021 cgccttgccg ttggaacccg actcggagga gccgaagttg ttgaggatca gcgcgcccgg
     4081 aaccagctcc tgaagctggt cgcggaccgt ctgcgacatg atcgcaccgg acgaggagac
     4141 gctgaacagc gaggagaggt cggtcccctt gagcggaccg tgcagggcgt cgatcagtgg
     4201 ccgcagcatc gcgtcgccca ccagggacac actggtcacc ttctccttct cgatcgtacg
     4261 gagcacctcc tcgggcacgt acttgcggtg gatgaccacc cgctggccgt agtcgaaggc
     4321 gacgaacgag gtgagcgtcg aggtgccgtg catcagcggg ggagcgggga agaaggtcag
     4381 gcccgcgccg cccttggcga cccgctcggc cagttcctcg ggccgtttca ccggctcgcc
     4441 cgccgggtcg ccgccgaaca acccggcgaa gaacaggtct tcctgacgcc acatcacgcc
     4501 cttcggcaag ccggtggtgc cgccggtgta gatgatgaac aggtcgtcac cggagcgcgg
     4561 cccgaagccc cgctcgggtg atcccgacgc ctcggcctcg gtgaaggcga ccgccccggc
     4621 gaccctcgcg ccgccctcgg ccgaccccgc gccgccctcg gccgaccccg cgccgccctc
     4681 ggccgacccc acaccgtcct cgacggcccc cgccccgccc tcggcggccc ccacccggat
     4741 cagatgccgc agctttcggg cctgcgtgag cgcgcccgcc acccgggggg agaactcggt
     4801 gtcgaacacc agcgccgcga gatccgcgtc ctgataaaga taggccaact cctcttccac
     4861 ataacggtag ttgacgttga ccgggaccag gcgcgccttc agcgcggcca ggacggtctg
     4921 gaggtactcg acgccgttgt agaggtgcag gcccaggtgc tcgccgggct tgagccccgc
     4981 gtcgatcagg tggtgcgcga gccggttggc cgccgtgtcc aactggcggt aggtcaacct
     5041 gcgttcggcg cccgttccgg gatggtcgag gtagacgagg gcttcgcggt ccgggaccac
     5101 gtcgacgacg gactcgaaca ggtcggcaag gttgtactcc accattcctc ctgacaccgg
     5161 ccccgactga ctgggggtca tcagagcaaa gccgcgcaga actgggaagg gcgtcgccga
     5221 agaaatctga ctgactgtca gaaaactatt gaactggcac ctcccctact gcaacctgtt
     5281 ctaggtcttg agacgggagg acggcaatgg gtggtacgga acacctcacc gtgcagcgcg
     5341 aaggcgccac gctggtgctc accctcaacc ggccggaagc gaagaacgcg ctctcgcttc
     5401 cgctgttggt ggggctctac gacggctggc tggaggccga cgccgacgac tcgatccgct
     5461 cgatcgtcct caccggcgcg ggcggcgact tctgcgcggg catggacctc aaggccctcg
     5521 cgggcggggg catggcgggc gaccactacc gggaccgcct caccgccgac cccgatctgc
     5581 actggaaggc gatgctgcgc caccaccgcc cccgcaaacc ggtgatcgcc gcggtcgagg
     5641 ggtactgcgt ggccgggggc accgagatcc tccagggcac cgacatccgc gtcgccgggg
     5701 ccggggcgac gttcgggctc ttcgaggtga agcgcgggct ctttcccatc ggggggtcca
     5761 cggtgcggct ccagcggcag atcccgcgga cccacgccct ggagatgctg ctcacggggc
     5821 ggccgtacag cgccgaggag gccgtgcgga tcgggctgat cgggcgggtg gtgccggacg
     5881 gtacggcgct cgacgtggcc cttcggatcg cctcggagat caacgcgtgt gggccgttgg
     5941 cggtggaggc ggtcaaggag tgtgtgtacg ccacggcgtc catgggggag gcggaggggc
     6001 tggcgctgga gttggagcgg gggtggccgg tgttcgcgac ggaggatgcg aaggaggggg
     6061 cggcggcgtt tgccgcgaag cgggtgcctg tgtttcggcg ggggtgagga ttccccaccc
     6121 cgccccttcc cgaaaccctc cgggggctcg gtcgggtgcg ggccggtggt cgatcccggg
     6181 gctccgcccc ggaccccgtt cgcgccttga cggcgctcgt cctcaaacgc cggacgggct
     6241 gtaggtggcc ccagtcggcc cgagggccca gacgacggac gagttgtagg tggccccagc
     6301 cgactcgaag gcccaaaccg ccggacgggc tgtaggtggc cccgaattta ggagttggat
     6361 catggcagga tctgccgcga ccgaggtgtt gcgtgcgccg cttgttgttg agtttccgtt
     6421 cacccggtcc ctcgggcccg ttcagagtgc cttccttacg gggctgcgcg agcgggtcgt
     6481 gctcggggtg cggacggggg acgggcgggt gctcgtgccg cccgtcgagt acgaccccgt
     6541 caccgcggag gagatccgcg agctcgtcga ggtcgcgccc gccggcaccg tgaccacctg
     6601 ggcctggaac ccggccccgc gccgcggcca gcccctggag cggcccttcg cctgggtgct
     6661 cgtcaagctg gacggggccg acacctcgct cctgcacgcc ctggacgcgc cggggcccga
     6721 cgccgtgcac agtgggatgc gggtccgcgt ccgctgggcg caggaccgca cgggcgccat
     6781 cacggacatc gcctgcttcg aaccggacga cggtggggag gaggcccaac cctgcggtca
     6841 cagcggggag ttcgaagacg ccgtcaccgg catcgtcgcg cccgcccggc tcgactacac
     6901 ctacagcccc ggccgcgccc agtccgcgta catcaacgcg ctgtccgccc ggaagaccgt
     6961 cggcgagcgc tgcccggact gccgcaaggt gtacgttccg ccgcgcggcg cctgcccgac
     7021 ctgcggggtc gccaccgagg agcgggtcga ggtcgggccg gccgggaccg tcaccacgta
     7081 ctgcatcgtc aacatcaagg cgaagaacct cgacatcgaa gtgccctacg tctacgcgca
     7141 catcgcgctc gacggcgccg gcctcgccct gcacgggcgg atcggcggaa tcccgtacga
     7201 ccaggtgcgg atggggctgc gggtcgaacc ggtgtggagc gagggcggcc gctaccccga
     7261 ccactaccgg cccaccggcg aacccgacgc cgactacgag acgtacaagg agctgatctg
     7321 atggcgccca ccggacccgg ccgggacgtg gcgatcgtcg ccttcgcgca gagcgaccac
     7381 cggcgccgca ccgacgagct gtccgaggtc gaactcctca tgccggtgct gcaccaggtc
     7441 ctcgacgcga ccggcctcaa gaccagcgac atcggcttca cctgctccgg ctccagcgac
     7501 tacctcgccg gacgcgcctt ctccttcacc atggcgctcg acggcgtcgg agcctggccg
     7561 cccatctccg aatcgcacgt ggagatggac ggggcctggg ccctgtacga ggcctgggtg
     7621 aagatcctca ccggcgaggc cgacaccgcg ctcgtctacg gatacggcaa gtcctcgccc
     7681 ggtgaggtgc gcgatgtgct gacccgtcag ctcgacccct actacgtggc gcccctgtgg
     7741 cccgactccg tctcgctcgc cgccctccag gcgcaggccc tcatcgacgc gggcgacacc
     7801 gacgagacgg cgctcgcctc gatcgccggg cgcagccggg ccgctgccac cgccaactcc
     7861 catgcgcagg tgcgtggttc gcgtgcccag ggcgagtacg tggtgcgtcc gctgcgcacc
     7921 ggggactgcc cgcccatcgg ggacggcgcg gccgccgtga tcctcgcggc cggggaccgg
     7981 gcgcgcgacc tgtgcgcgcg gcccgcctgg atccgcggca tggaccaccg catcgaggcc
     8041 cacagcctcg gcgtgcgcga cctcaccgac tcgccgtcca cccgcctcgc cgccgaacgg
     8101 gccggtttct tcgaacggcc ggtggacacc gccgagttgc acgcgccctt cacctcgcag
     8161 gaggtggtcc tgcgcaaggc gctacggctc ggcgaggacg tcagcgtcaa cccgtccgga
     8221 ggcgcgctcg cggcgaaccc cgtgatggcc gccgggctgc tgcggctcgg cgaagccgcc
     8281 gcccgcatcc acagaggcga ctccgaccgt gcactcgcgc acgccacgtc cggcccctgc
     8341 ctgcaacaga acctggtcgc cgtcctggag ggggagtcat gagcaaggaa cccgtggccg
     8401 tcgtcggcgt cggccagacc aagcacgtgg ccgcccggca cgacgtgtcc atcgccggac
     8461 tcgtccgcga ggccgcccaa cgagccctcg aagacgccga gttgacgtgg gccgacatcg
     8521 acgccgtcgt catcggcaag gcgcccgact tcttcgaggg cgtcatgatg cccgagctct
     8581 acctcgccga cgccctcggc gcggtcggca agcccatgct gcgggtgcac acggcgggct
     8641 ccgtcggcgg ctcgaccgcc ctcgtcgcct ccaacctggt cgccgcccgc gtccaccgca
     8701 cggtgctcac cctcgccttc gagaagcagt ccgagtccaa cgccatgtgg ggcctgtccc
     8761 tgcccgtgcc cttcacccag ccgctgctcg cgggcgccgg cgggttcttc gcgccccacg
     8821 tacgggccta tatgcggcgc accggcgccc ccgacaccgt gggctccctc gtcgcgtaca
     8881 aggatcggcg caacgccctc aagaacccct acgcccatct gcacgagcac gacatcaccc
     8941 tggagaaggt gcaggcctca cccatgctgt gggacccgat ccgctactcc gagacctgcc
     9001 cgtcctccga cggggcctgc gcgatggtcc tcaccgaccg ggcgggcgcc gcccgttcgc
     9061 cccgccccgc ggcctgggtc cacggcggcg ccatgcgcag cgagccgacc ctgttcgccg
     9121 gcaaggactt cgtgtcgccc caggcgggca aggactgcgc ggccgacgtc taccggcagg
     9181 cgggcatcgc cgacccgcgc cgcgagatcg acgccgtcga gatgtacgtc ccgttctcct
     9241 ggtacgagcc gatgtggctg gagaacctgg gcttcgccgc cgagggcgag ggctggaagc
     9301 tcaccgaggc cggcgtcacc gaactggacg gcgacctgcc cgtcaacccc tcgggcggcg
     9361 tcctgtccac caaccccatc ggcgcctccg gcatgatccg cttcgccgag gccgccctcc
     9421 aggtgcgcgg tctggccggg gaacaccagg tggcgggggc ccgcaaggcg ctcggccacg
     9481 cctatggtgg cggatcccag ttcttcgcga tgtggctggt cggcgccgaa ccacccgccc
     9541 gttgaggaca ccgggcgagg ggcgggcccg gtaccgcttc cgcggcctgt ccgtcccccc
     9601 gcgcgatcgc tagtgtggcc cccggacgac agcaccgggg aggagcacgg acgtggccga
     9661 caccaccatc accacccagc acaccttggg gacccttgcg gggcacaccc gttccggctg
     9721 ggagaagccg gagctcgatc tcagcaaggc cgaatggcgg tcgagcagtc agggggcggg
     9781 agatgtccag atcgccttcg tcgaaggctt catcgccatg cgcaacagcg ccagccccgg
     9841 cagcccaccc ctgatcttca gtcccgccga atggcgggcc ttcgtgatca acgcgcgtga
     9901 cggcgagttc gacctgacct agccgggccg gagcacggcg gtgcgcgcct ccggttccgc
     9961 caccgcgcgg tggcggcccg gacgcgcgca ctgccggcct ctacgcgccc tcgcgctccc
    10021 cggaagcctg ctcggggaag agttgggccc acggccgctg acggccctcg ctgaccgcgg
    10081 cgatgcccgc ctcgccgtac cgcgccgtct ccagggacca ggccaggttc ccgctcatca
    10141 gggcgcgcat gccgtcgacg taatcgtcca cctgggcccg cactcgctcg ggaagctcgg
    10201 tcgtgtcgag ctgcgcggcg agctcgaccg tcagctcctg gaagcgtgcg atccgggagt
    10261 tggccatggc ggccacccgg cgcaccgcct gatcgacgga gcacatctcc tgccgtaaca
    10321 gaatgatgac gctgttgttc acatcgcccg ccgccagctc cttgtccacg gacaccatgt
    10381 cgttgacgaa gatcaccaca tcggcggtga tcacccgcat ctcggccagc ggcgccccct
    10441 cgtgcaactc cctgggcagc gtgtaacccc cgcagcgctc caccaggtcg agacagggct
    10501 gcacccctat ggagtcccgg cggccgcgta ggaagagagg cagggtcaac gtgccgttgc
    10561 gggtccggtt cagggcctcc cagtgatatg ccgtcagata ctcgcgccag tgcgcccgga
    10621 agcggtcctg ccacaggagc ggggtgcccg cggtcacccg ctgccacaga tcacgaaaac
    10681 tttcggccag ccggttcgtg gcttcgcccg gcaccggcgg ctcgtcgctc atggtgcgca
    10741 agaccgtatc gatctgacgc accaccacgt cgggccgctt cccgagcggc ccgtcgaact
    10801 ggtcgtcgaa gacgaagaac caggcgttga ggtccgtcgc cagggcgaga tgcgcgtccg
    10861 aggcgtccgg atagaagtac gccatcagcc gttccaggcc catcgcgtcg tattcggccg
    10921 tcgcctgctc tccggccaac atgccgaact cgtacagcca gtccagcgtg tgccgccggg
    10981 ccagctcgtg ccggggatgc cgacgagccg gaaagggaat gtcgacgagc cccgtccgcg
    11041 tccgggccga ccggactctg ccagtgctgc ccatacggca ccgcctcctt agtactccgt
    11101 acgtcgttca atcatcaagg ggaggtgggc cggtgaccag tcgcatcacg ccggagcccg
    11161 acagcgcacc gggggcgtac gtggtccctc ctggcgcccc tcggggacaa tccgagccca
    11221 accgcccatg aattcagcca acttaacgag tcaaggagaa gacggaagta ggttattcat
    11281 gtcacggtac gtgtccgggg cgtaggctcg gtgctactgc cagaagggga accgctgtgg
    11341 cggagacgag aggtcggggc ggagcgccgc gccggagagg ggagcgctgc caacggcggc
    11401 ctgctcgcca tcgccggatc ggccggcctg ggcaagacca ccctcgtggc cgaagtgcgg
    11461 cgcaaagccg ccgcccgtgg ctgcaccctg ctggccgccc gcggcagcga gcaggaggag
    11521 ggcgtcgcct tccacgtcgt acgccagctc gtacaaccgg tgctggccgc gaccagcgag
    11581 gccgaacacc gcaagatact gggcagttgg tacgacatcg tcgcacccgc cgtcggcctg
    11641 gtcgcgggac agagcggggt ctcgcccgac ccccagggcg tgcgggacgg cctcgactgg
    11701 ctcgtcaccc gcttcgccgt ccagtacgcg cccgtggtgc tggtggtcga cgacgcgcac
    11761 tgggcggacg aggagaccct cgcctggctc agctcgttcg cgctgcgcgc cggcgatctg
    11821 cccctgctga tcgtcgtcgc ctaccgaccc gaggaactcc cgcgccacgc cgccgagttc
    11881 cgccggctcg ccatgcggca cggctcgcgc ccgctcgacc tgtcaccgtt caccccggcc
    11941 gccgtcagcg acctggtgcg cggcgtgctc ggcgacggcg gcgacgaact gttcgcccgc
    12001 gaatgctggg cgctgaccgc gggcaacccc tacgaggccg tcgaactcgt cgccaggatc
    12061 cgtgaccgag gcatcaagcc gcagtacgcc aacgccggcg aactgcgcga actggcctcc
    12121 gccgtacgcg gcagcggact catcgagcgc ctggagcgac tcggcccctc cgcggtacgg
    12181 ctcacctggg ccgtcgccgt gctcggcacc gacgccgacc gggagatggc ggccggcgtc
    12241 gccggactgg gcgccgagga gatggccgac gccgtcgagc ggctgcgcga cgcccgcatc
    12301 ctggccgggc cgaccgaggg ctccaaccgg ctcgacttct tccacccact cgtcggcacc
    12361 gccgtctacc gggccatccc cgcggccatg cgggtcgcga tgcacggtca ggccgccttc
    12421 gcggtcaccg aggccggact cggcgccacc gccgcggccc ggcacatcct ggaaatgcat
    12481 cccgacaacg accgctgggc cgtccgccaa ctgcgctccg ccgcccgcga ctacctgcgc
    12541 gccggcgccc ccgacgcggc ccggcgctgt ctgtcccgcg ccctgcgcga accacccgcg
    12601 ctcgaagaac gcgccgaggt gctctacgaa ctgggctgct cggcgctcct gaacgagccc
    12661 gccaccaccg tcaaccacct cagggccgcc ctcgaagaac ccgaactcgc cccggaactg
    12721 cgcgaatccg tcacctaccg gctcgcccag gcactggccc acaccgaccg catggcggag
    12781 gccgccgccc tcgtggccgc cgaggccaaa cactcctcca acgcccgcac ccggctccgc
    12841 atgcaggccg agacgttcca gtggaacgcg ttccgcgccg acgaggagga ctcgccgacc
    12901 cgctcgcgca gcctggcccg gctcgccgag cacctcaccg tccggggcaa ggccgagcgc
    12961 tacatcctgg gcctgcgcgc ctgggacgcg atggtgcgcg gcgagcccgc cgagaccgcc
    13021 cttcgctacg ccgaggaggc gctggagggc gggctgccct ggaccgacga caactggggc
    13081 ttcgaggtgc ccgtcctggt cgcgctcacc ttcatgtact gcgaccagcc cggccgggcc
    13141 gacgaactgt tcacccaggg catcgccgac tgcgagcgca agggctggcg cggcgcccac
    13201 ctctccttcg gcctgacgct gctgggctac atcaagttcc accgcggccg gctcgccgag
    13261 gccgaggacc tcgtccacag cggcctgcgc atcgccgacc gggtcggcca gcagatcccc
    13321 gcccagtggt tcgcgctcgg catcctcatc gagatcctgc tcgcccgcgg ccgggtgcag
    13381 gaggcgcagg aactgtccga cgcctacaac tacggccagg tcgttcccaa cgccgtcgtc
    13441 taccccgact ccgagaccgt ctacagcgaa ctcctgctcg cccgggggct gcgcaccgac
    13501 gccgaggagc ggctgcgcgc ggtcggtcgc cggctcgaac cgcgcgggat gcgcaacccc
    13561 atgtggtgcc cgtggcggcc gctcctggcc cagacgatcg cccacaccga ccccggcgag
    13621 gccgccgaga tcgcgcagga aggggtcgag atcgcccgtc gcttcggcac ccccggcgcc
    13681 atcggccgag ccctgcacgc ggcggcgaag gtcgcctccg gcgccgacag cctgtccctg
    13741 atgtccgagg ccgtccggca actcgaacgg tccccggccg cctacgagct ggcgcaggcc
    13801 ctgatcgacc acggcgcgat gctcagccgc gccgggctgc cccaggacgc cgcggacctc
    13861 ctgatgcgcg gcctggagag cgccgcgctg tgcggggccg acgcgctggc ggcgcgggcc
    13921 cgcgaggaac tcgccgcctc cggtctgcgc ccgctccagc tgcgggccgt ggactcggac
    13981 tcgctgacct cgcaggagaa ggcggtggca gagcgggccg cccagggctg ggagaaccgg
    14041 cgcatcgcgg aagacctcgg catcaaggag cgcaccgtgg agctcctgct ctccggcgcc
    14101 ttccgcaagc tgggcaccga ccgcggcggt ctggccgggc tgctgcccca ccagacgcgg
    14161 ggctccggcg tccggggcgt ccccggtccc tgaggccacg ccacccggcc ccggcccccc
    14221 gagccacacg gcaggggggg ggccggggcc gcgctccgcg tcgacccgcc cagggccccg
    14281 ggcccggctc cggcggggcg ccgcgggcac gtaccattga cggcatgtcc ttcctccgcc
    14341 gccgcagcgc cgccactccc gcgggcccgg acttcgatgt cctggccatg gacccgggtg
    14401 actggcccgg caacctgggt gccggtctgc tgcccgcccc cgacggcagc tgccagggtg
    14461 tcttcctgcg ctacgacctg ttcggcggcc gtggccccgc gatgatcatc ggcaatctgc
    14521 cggagggatc cccggcccgc gagatggccg agggccaggt ccccttcgag gtggcgcagc
    14581 tcctggtggc gctggagaac gacgagtcga tcgaggtcgt cggctccgag gacatgccgg
    14641 tgatgcaggg cgacaacctg ctgatcgtgc gccgcctcaa gctctccgaa agccgcatct
    14701 cctgcgtgca gttcgaccgc agcgacaacg tcctggtcac gatcgccagt tgggaccggc
    14761 ccatcaccga tgacctgtat gccctgctga agccgctgcc cgcggagctc ttccagcagg
    14821 gctgagcggc acaccggcga tcggccccac ggcccggcac cttccgtccg aggtgccggg
    14881 ccgtttcgtg tcccgagccg cctcatgtcc caaaccgctt catgtcccga gccgtcaacc
    14941 gggcccgccc cggcggccgt tgacccctcg cgccaacggc aggtcgggcg ccccgccaga
    15001 ggtctcgtcc actgacacaa gtcgctttgt gcgacgacta cttgacgaag cgtcattctg
    15061 ggtcacagtg tgtccccgcg cggaccgacg cgtcgcacgg cgagagaacc caccgcaccc
    15121 cggcaagaag ggctgtccat gacgtccaag cagaggatca gactcgcgct cgcggcggcg
    15181 acggccggcg ccctgggcct cgccctggcc cccgcctccc cggcgagcgc ggcggggccg
    15241 gacaccgagt gcccccgcac cctcacctgc gactgggttc cggcggccta ccagcagacc
    15301 ggcgatcccg ccgacaagaa gacgtacggc aattacgacg tctcggaccg cccgggcacc
    15361 aacaagatca agtacatcgt cctgcacgac accgaggaga ccttcgcgac caccctgaag
    15421 atcttccagg accctaagcg ggccgcctcc gcgcactacg tggtgcggtc gagcgacggg
    15481 cacgtcaccc agatggtgaa gaccaaggac gtcgcctggc aggccggcaa ctggtacatc
    15541 aactccgact ccatcggcat cgagcaggag ggctacgcca ccgccggcgc cgcttggtac
    15601 accccggaga tgtaccgctc gacggcggcg ctggtgcgct acctcgccgc caagtacgac
    15661 atcccgctcg accgccagca catcctgggc cacgacaacg tgccgcccac caccgcggcc
    15721 ggcacggcgg gcatgcactg ggatccgggg ccttactggg actggaacca cttcatgtcc
    15781 ctgctgggcc ggcccaccca gcagaccggt cgccccggcg gtcaactggt caccgtggac
    15841 ccggtgttca agaagaacct ccaggccttc cgggactgcg agaagaacgt ggacctgccc
    15901 gcggcgccct ccagcgcggt cccgctgtac acccaaccct ccaccgacgc cccgctgttc
    15961 gccgaccccg ggctccaccc gccgggcacg cccggaacca actgcgccaa cgactggggc
    16021 agcaagatca gcgccgctca gcaggccgtg gtggccgaac gcaggcccgg ctggaccgcg
    16081 atctggtggt acgggcagga ggcctggttc cagagccccg cccacacccg caccaccacc
    16141 ccgaccgcgg gctatgtcgt acgccccaag ccgggcctca ccgatgtgcc ggtctacgga
    16201 accgcctatc cggcggccgg tgactacccg ggtgacttca cggccccgcg ggtgagcacc
    16261 ccgctcgcct acaccatcaa ggccggccag tcctaccccg gcggagcgcc gacaccctcc
    16321 ggctacttct acgcccccac catcgactcg tcatacccct acgaccacac gtacttcccc
    16381 ggcagcatcc gctatgtgac ggtgcagatc ggccaccgga tcgccttcgt caaggcctcc
    16441 gacgtggacg tcgtccgcgc gcgctagccg catgacagcg cgccgcgcgc ccagtgtgtc
    16501 ggcactgggc gcgcggcgcg cttccccctc ggaccggtcg tcagcgggtg ccgaccgccg
    16561 cccgcacggc acgccgcgcc agcgcgcagt cgtcgtgcag cctgcgcagc agcagccgct
    16621 gctgttcccc cgcggacggc acgcccggcg ggttctgcgc cgcgctcgcc ggcgccgcgt
    16681 cacgcatggt gcgctgcacc gccgtctcgt acgtccggat ctcccgggtc agtacgagca
    16741 tcaggttcac caggaacgcg tcccgcgacg cgggccccgc cagctgggcg gcctggctga
    16801 tccgccgccg ctccatcggg gcctccccga gcaccgccca cagcgtcgcc aggtcgtatc
    16861 ccggcagata ccagcccgcg tgctcccagt cgaccaggac cgggccggtg ggcgagagca
    16921 ggatgttgga caggagcgcg tcgccgtgcg agaactgcca gtcgacccgg cccgagaggg
    16981 ccagaccgtg caccagcttc tgaaggtcac tcagatcccg gtcggtgaac aggccgagct
    17041 cgtggtagcg gctgatgcgt ggcgcgtagt ccaggggcct gccgaacatc tcggcaggcg
    17101 gccgccaggc gttgacgcgg gcgatcgcac cgagggcggc ccggacatcg gcacgcggcg
    17161 gagcctcgac gggatgtcgg gtgagggccg cggcccggcc cggcatccgc tcgatcacca
    17221 gggtgcagtt gtcggggtcg gcggcgatca gtcgcggcac ccgtaccggc ggacgatgcc
    17281 ggacgaacgc gcgatatgca gctatttcgt gccggaaccg ctcggcccag gccggcgagt
    17341 ggtccagtaa acacttggcg acggccgtcg tccgtcctgt cgtgccgacg atcagcacgg
    17401 agcgtccgct gtgccgcaac acctgcaccg ggttgaactc gggacagatc cgctgcaccg
    17461 aggcgatcgc gatgcgcagt tgggcgccct gggggccgga gaggtcgatt cttccgctca
    17521 gcggctgcgt gcccgttccg gatcggcgcg gcatccggct cgcgccgtag gccgatcccg
    17581 cgtgggtggg gtccagatac ggtccgccac ccgctcccag aggtcggtgc ggccggggcg
    17641 gcgtggacac ggaggacgat gctgtgtaca tgggggtgac agatcccttc gtgtgccgac
    17701 aagttgcgtg cgctacccgc cccggtggcc gagccgcacc ctggggaatg aggtccggcc
    17761 cccgggtcgg ggtggcgctc tcttacctga cacccggccg cgggtggcac accatctggc
    17821 gtgccctggc gaaccctggc gaatagtcgc gccgcatctg acaggggatt actgtcaact
    17881 cagccgagaa cctgggggct tgacgtgagc ggacaaccca acacccgcct gaacgacctg
    17941 ttcggcctcg ccggatggtc caagggtgaa ctcgcgagaa tggtgaaccg gcaggcggcg
    18001 gccatgggcc acccccaact ggctaccgac acctcgcggg tgaggcgttg gatcgacatg
    18061 ggggagaccc cgcgcgatcc ggtgccccgg gtgctggcgg cgctgttcac cgagcggctc
    18121 ggccgtgtcg tgaccatcga ggacctcggg ttcgaccggc acgggcgcgc tggaaagcgg
    18181 aacgacgtca ggaatcccaa gaatccggac ggcgttccgt gggcgcccga acggacggca
    18241 gcggtcctca ccgaattcac gggaatggac ctcatgctca accgacgcgg tctggtgggc
    18301 gcgggcgccg cgctcgccac cggctcagta ctcagcagcg ccatgcacga ctggctgcac
    18361 accgaccccg tactctcggc cgacgccccc cgcctccacg accccctgca cgccgatccc
    18421 gccgggttcg accgctatga ggccgccccc atcggatcgc aggagatcga cgcgctggag
    18481 cgctccgtcg acgtcttccg cgcctgggac gcctcccggg gtggcggact ccagcgcaag
    18541 gcggtggtgg gccagctcaa cgaggtgggc ggcatgctcg cctaccgcca ccccgaccac
    18601 ctccagcggc gcctgtgggg cgtcgccgcc aatctggccg tcctcgcggg ctggatgtcg
    18661 cacgacatcg gcctggagcc gaccgcccag aagtacttcg tcatcgccgc ccacgcggcc
    18721 cgtgagggcg gcgaccgccc ccgcgccggc gaagccctct cccgggccgc ccgccagatg
    18781 gtccacctgg gccggccagg cgaggccctc gacctcatga agctcgccaa gtccggctcg
    18841 ggcgaggaga ccctgccgcg cacccgggcc atgctgcaca ccatcgaggc ctgggcgcag
    18901 gcgtcgctgg ggcgcggcca ggcgatgcgg cgcacgctcg gtgaggcgga ggaactcttc
    18961 gtctccgaca agggcgatgt gccgccgccc agttggatgc agatgttcga cgaggcggat
    19021 ctgcacggca tgcaggcgct ggccttccgt acgctggccg agcacgatcc cgccgcggcc
    19081 accatcgcgc agcaccacgc caaacaggcc ctggagctgc gggtgggcgg ccgtcaacgc
    19141 tcgaagatct tcgactacat ctcgctggcc tcggcctgct tcatcgccga cgaccccgaa
    19201 caggcggacc gctatgcccg cctggcgctg gtgtcgatgg gggagacctc ctcgcaccgc
    19261 acctgggacc ggctgcgcga gatgtaccgg ctcaccagtc agtacgccgg gtacggcaag
    19321 atccaggatc tgcgggagga gatccaactg gccctgcctc aggcgccggt gaagcggagc
    19381 cgggtcgcgg acatctagaa gtccggccct tgcggccggc ggttgctcac gaggcctgtg
    19441 ccagtaagcc agtagccagt aggcctgtgt gtgcgaagcc ccgggcgtca ggacccgata
    19501 cgggccacca gcacacaggc gtcgtcctca cgctcgtgct cgccgaactc ctcgacgatc
    19561 atccgtacgc agtcctgggc tgtacggcca ccgtcgaaga gcggggcgag tgcgagcagt
    19621 cggcgctggt cgccgtcgtc gcaggcggcg cgccgggtca gtccgtcggt gtgcaggacg
    19681 agcagatcgc ccgcgtgcaa ggtggcctcg gcctggtcgt aggcggcccc gtgcgtggcg
    19741 ccgagcagga ccccgcccga tgcgccgagc gcccgtcccg tcccgccgcg gaacagcagc
    19801 ggggctgggt ggccggcccc ggaccagacg agcctgcgcc gggcgggctc gtaacggcaa
    19861 cagaccgcgc tgcccagggc gggctgcacg gtcgtttcca ggagctggtt gagatgtccc
    19921 atcagggggc cgggcccgat gcccgcgacg gccatgccgc gcagcgcacc gagcagcatc
    19981 gccatgccgc cggtcgccgt cactccgtgg cccgtcagat cgccgacggt cagtaaggag
    20041 gcgccacccg ggagttcgag cgcgtcgtac cagccgccgc cgatgaggtc gctggccgag
    20101 gacggcagat agtgcgcggc gatgtcgagc gcgccggggc cgccgtgcgg gagcctgagg
    20161 gagccgcgcc acggcggcag cacggcctcc tgcaactcga ccgcgagacg gtgctcggtc
    20221 cgcgcgatcc ggcgctggcg ctggaggcgg tcgcggctct cccgcacggc gcgctggctg
    20281 cgccgcagct cgctcacatc gcgcagcacg gcccacatcg aagcggtgca gccgtcggcg
    20341 tcgagcaccg gctcgcccat catgtggagc gtggtgatcg tgctgtcggg ccgcacgatg
    20401 cggaactcgc cgtcgatggg cctgccgtcc accagggcgc ccgtcaccat cgtggtgagc
    20461 agggcctggt cctcgtcgac caccatggtg ggcagttcgt cgagcgacat gccgccgctc
    20521 tcgggggagc ggccgaagat ctggaagagc tcctcggacc agctcaccgc gtcggtgagc
    20581 agattccact cggcgctgcc gacccggctg agcgggccgg gggcgtccgg gccattgccg
    20641 aaggagctct cgacggcgag cgtcgtcgcg tcctgttcct cggcggtcgg accgtcgcgc
    20701 aactggtcca agtgcgcgcc caggtcgtcg agttgatgga ccgccagatc gcacagagcg
    20761 cgctgccagc gggcctgggc gtcgtcgtcg tccacgaagg cgtcgcggcg caccgcgtcc
    20821 acgcccccgc gcagcctgcg ggtctgcgtg atcagtgcgt cgaccgtgcc ccgctcgggc
    20881 ggttggggag cgggacggtc cgcgaacaga tgggacggca tgacgttctc cgatgcgacc
    20941 gcggtagagc ctggtctggc gaagtggacc ggttacgact cttgcacagg gagcgatgcc
    21001 ccgtaaggga tttggcaaca ctcgatacgg tggtgctcgt gacatatgcc aacggcgacc
    21061 ggtttcggcg tccc
//
