LOCUS       NZ_CP032698            10528 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4823540
            Orig. end                         :: 4834068
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10528
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="24"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10528
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10528
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5528](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5528
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    147..162
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.68"
                     /tool="antismash"
     misc_feature    complement(1055..1068)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.65"
                     /tool="antismash"
     gene            1357..1596
                     /locus_tag="DWB77_RS21480"
                     /old_locus_tag="DWB77_04334"
     CDS             1357..1596
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746416.1"
                     /locus_tag="DWB77_RS21480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04334"
                     /product="chaplin"
                     /protein_id="WP_120722790.1"
                     /transl_table=11
                     /translation="MSRTAKALVMSTAAIATIAGGAGVAAADAGAQGAATNSPGVLSGN
                     LLQVPVHVPVNVCGNTVNVIALLNPAFGNTCVNK"
     gene            1752..2645
                     /locus_tag="DWB77_RS38470"
                     /old_locus_tag="DWB77_04335"
     CDS             1752..2645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382606.1"
                     /locus_tag="DWB77_RS38470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04335"
                     /product="hypothetical protein"
                     /protein_id="WP_216826859.1"
                     /transl_table=11
                     /translation="MRARTPRRLAAVALSTAIVIATAGAAAAEGVQPPRPVAAEAAVPG
                     SDEVLQQVKVLADLGGVLKPVTDLLTAALGGKSPAEITALASGATSALDAAKSATPAAL
                     VPAKPATPANPALPATPDKPATPANPAAVPATPANPATPANPALPATPAKPATPANPAL
                     PATPANPATPANPAAPAAPATSVRPVMPAAPVTPTSPALSALPLSGQPQAAGPVDVRAD
                     AVAVLKKSVDDLVKAVTSAKADGVVPAATSVVTGLVGLVVATLVGAGLPVPSLPGLPQP
                     PKSPAGSLPAAPGLPA"
     gene            2847..3146
                     /locus_tag="DWB77_RS21490"
                     /old_locus_tag="DWB77_04336"
     CDS             2847..3146
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325462.1"
                     /locus_tag="DWB77_RS21490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04336"
                     /product="hypothetical protein"
                     /protein_id="WP_342777986.1"
                     /transl_table=11
                     /translation="MKVAAAVAGSLAVMGAAAPAFAAGGTPPMPPMSLNGGLDSLTNAA
                     SHAQLADAAPVNTSALDPKSDGSVLHAVTSAAHDLNKSHGGSGSGRMLGGLPIG"
     misc_feature    complement(3412..3424)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            3458..3958
                     /locus_tag="DWB77_RS21495"
                     /old_locus_tag="DWB77_04337"
     CDS             3458..3958
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003505.1"
                     /locus_tag="DWB77_RS21495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04337"
                     /product="DUF5949 family protein"
                     /protein_id="WP_120722792.1"
                     /transl_table=11
                     /translation="MTSASSAVQPSRAALLGSLIVIAWSGEHPDESGDMPFLMAYPLGD
                     GVQGPEGAEVAARAFLEEIGMPPGSVVDQSHGGSFPLTLIVQAGRAVLTLPTMTAQCPA
                     PPEWLAAAERRGTVQFIFATRSWPEAVPGVAVTDEQLRAFAGDEATITTAGHCLLPIRR
                     LRG"
     gene            3995..4645
                     /locus_tag="DWB77_RS21500"
                     /old_locus_tag="DWB77_04338"
     CDS             3995..4645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003506.1"
                     /locus_tag="DWB77_RS21500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04338"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_120722793.1"
                     /transl_table=11
                     /translation="MPFHGTLQEPAPLTDSSGPPPPPSTAFGAGRGFARLVVLTGAAGL
                     LASWVITLDEFELLRNPDFVPGCSLNPVISCGTIMKSAQASVFGFPNPMLGLVAYGIVC
                     CVGMSLLGGGRFGRWYWLALNAGAAFGVVFVGWLQFESLYRINALCLWCCLAWVATIVL
                     FWRVTHLNVINGALPAPGWARELSAEFGWAVPVVHIGVVAMLILTRWWDFWTR"
     gene            5001..5528
                     /locus_tag="DWB77_RS21505"
                     /old_locus_tag="DWB77_04339"
     CDS             5001..5528
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116481.1"
                     /locus_tag="DWB77_RS21505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04339"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_120722794.1"
                     /sec_met_domain="melC (E-value: 7.4e-33, bitscore: 112.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDAPHFWSARRTGRTRLRSRAPEPTGPGAPPPRTAWRTARRGLL
                     RALFASAAVAFTGAALSRIPSAAPAGATGPGPTARVPESMLFDEMHAGHRIQGRALQAD
                     GSEVAVFVDDRRLMLMRRADGTYLSAVDHYESYATAREAARAAAAELGRARLAAVPVHA
                     GHEGGAVRGVHA"
     gene            5512..6381
                     /locus_tag="DWB77_RS21510"
                     /old_locus_tag="DWB77_04340"
     CDS             5512..6381
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071025.1"
                     /locus_tag="DWB77_RS21510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04340"
                     /product="tyrosinase family protein"
                     /protein_id="WP_120722795.1"
                     /transl_table=11
                     /translation="MVYTRKNQRNLTSAERKAFVNAVLELKRRGTYDAFARTHIDFYVS
                     DGDRGLRVAHMAPSFLPWHRRFLLEFERALQKVDPRVTVPYWDWTRDSSAASSLWGDDF
                     MGGNGRRGDLQVMTGPFAHAHGHWDITVNVTDERFLTRDLGRPKNPIKLPTAADVAQAL
                     ADPVYDVSPWNSMSGTGFRNKLEGWTKASGDARFRTHNQVHRWIGGIMLGGAAVNDPVF
                     WLHHAFVDSLWSRWQAAHPKSKRYLPDVPPPLGDLQHGRVAALHDPMPPWNVAPAALLD
                     HSRIYRYA"
     gene            complement(6489..6764)
                     /locus_tag="DWB77_RS21515"
                     /old_locus_tag="DWB77_04341"
     CDS             complement(6489..6764)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116479.1"
                     /locus_tag="DWB77_RS21515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04341"
                     /product="chaplin"
                     /protein_id="WP_120722796.1"
                     /transl_table=11
                     /translation="MSRIAKTAAVVAGAGAMALAGAGMAAADAGAEAVASNSPGVLSGN
                     LVQVPVHIPVNLCGNTVDVIGLLNPVFGNTCVNDSHLLHHHGGYGG"
     gene            complement(6915..7244)
                     /locus_tag="DWB77_RS21520"
                     /old_locus_tag="DWB77_04342"
     CDS             complement(6915..7244)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS21520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_04342"
                     /product="hypothetical protein"
                     /protein_id="WP_120722797.1"
                     /transl_table=11
                     /translation="MYKLSGSAARAALVTGLVSALGTGYAAHATDRPGAAPPPASAPHT
                     APHTAPHAPGGAPVRPGAAPPTLADTGADANATLLGALSVGAVVTGAAAVALSRRSSRG
                     RYGEE"
     misc_feature    complement(7284..7299)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            complement(7407..8411)
                     /locus_tag="DWB77_RS21525"
                     /old_locus_tag="DWB77_04343"
     CDS             complement(7407..8411)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976086.1"
                     /locus_tag="DWB77_RS21525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04343"
                     /product="glycosyl hydrolase"
                     /protein_id="WP_246033599.1"
                     /transl_table=11
                     /translation="MRRASGTGPGRRRASNAASSWKAALCALVLLLSALVQPPGDRTRG
                     PMPTGARTAAGVFTGSDGDGIVKLAAVEKWRGQGRLRAGHTYLPGDTWSGIEGPPRLLA
                     PWARWRHERTDRVFVLNVPMLAPNEAGLPDAEVRGLLGQGARGAFDGHFTALAERLVAL
                     RLADTNVVLGWEMNGVTYTHRCAPDPASWRAYWRRVVTAMRSVAGQHFRFDFAPNRGRD
                     AVAWTECYPGDAFVDIVGMDSYDQPAGMSFREQVEEPYGLRAQVDFAARHGKPVSYPEW
                     GLFRNGDDAPYVRGMTAWFRRYRPVYQTLTDYCPHGVWECPDHPEAAHAYRAR"
     gene            complement(8420..8647)
                     /locus_tag="DWB77_RS21530"
                     /old_locus_tag="DWB77_04344"
     CDS             complement(8420..8647)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS21530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_04344"
                     /product="hypothetical protein"
                     /protein_id="WP_120722798.1"
                     /transl_table=11
                     /translation="MNTQRRLRAATAAASLLLLAAPGVAAADTGAGQGSVSEYGQPKVL
                     GGRGEIAETLTAGVAMFGGTLQPDGASGAH"
     gene            complement(8706..9986)
                     /locus_tag="DWB77_RS21535"
                     /old_locus_tag="DWB77_04345"
     CDS             complement(8706..9986)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845752.1"
                     /locus_tag="DWB77_RS21535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_04345"
                     /product="cytochrome P450"
                     /protein_id="WP_120722799.1"
                     /sec_met_domain="p450 (E-value: 6.6e-18, bitscore: 63.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHTRTIPAPSDACADLANPAFWKLPAAQRLARFTELRHEPRPVF
                     FTERPSTPRRAEQGFYALVRHADVLKASRLPRVFASAPGVTSPEPARWVRTLFGDSMVN
                     LDGADHARLRRIVQQAFTPRLLAATETHIRELAVRIVDDMVAERPDEFVSSVASRMSFE
                     VICAMLGVPDADRRRIARQIDRASEHAGVRRGLGARLMSPGKGLRALARMELTVARLGR
                     ERRRHPTGDLISALVCADVEGQALTYRQLGSFFSLLLVAGVETTRNAIAHALVLLTRNP
                     DQLALLTDDFDRYADGAVDEIVRHSTPIIQFRRTVTTRYTLSGHTFLPGDKVMLLYASA
                     NRDASVFTDPDVFDITRDPNPHLGYGGGGPHYCLGAHLARLEIKAVLRELLTRPLAVRA
                     LGEPELGTSNFDHRVRRQYFTFDAAKP"
     gene            complement(10063..10341)
                     /locus_tag="DWB77_RS21540"
                     /old_locus_tag="DWB77_04346"
     CDS             complement(10063..10341)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS21540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_04346"
                     /product="hypothetical protein"
                     /protein_id="WP_120722800.1"
                     /transl_table=11
                     /translation="MNVRRYLAAAAAGTAIAAALSPAAHALDLGNTLSKAATTTSAAGA
                     QVKPVAESAVGDKLGKKVTAVKNGVKAGTDAVKAAKDAVKAGRELMS"
ORIGIN
        1 cgccgggcac cgcatggcgt acgtcctgcc aggcccggag cagcacgtcc tggcccttct
       61 ggcgacagag ccgcccgaca cagaccacca ggggcgcgtc cgtcgcggcc cgcgccgtcc
      121 caggggcgcg gtagaggtcg aggtcgacgc cgttggggat caccgcgaac gacgcgagga
      181 ccccggcgcg ttccccggtg gcccgctcgc cctcgctgac gcacaccacc cgcgaggtcc
      241 accgcaccgc ggcccgctcc caactccgcg acaggcgctc ggtgatgccg cccaccgcct
      301 cgaacgacca ggcgtgcggc tggaagacgg tcggcacccg gccccgcgcc gcgagccggg
      361 cggcgacccc ggccttggcg ctgtgcgcgt ggatcacatc ggggcgtacg cgccggatga
      421 ggcgggccgc gcgcagcgtc tcgccgagca gcgcggggcc cggcgagcgg gtggcccgcc
      481 aggggaccac ccgggcgccc aggcgcgaca gttcggtgct caacgggcct ccctcggggc
      541 atgccacggt gacccggaat ccactgcgca gctggtcccg taccaagtcc gtgacgactc
      601 gggctacgcc cccctcaacg ggctgaacca ggtgcaggac actcaagtcg tgcgcgggcg
      661 gcccatcggg tccgccgggg gcgttggctc tcgtgggcat gcgcggtcac tccggtcctg
      721 gcgctcgaaa tgaaagctgg acaaagatgc tgcgggactc gcccagcggg cggtctgctc
      781 gtgaattccg ctttaccggt cgtgcggtcg ccggggttcc cacgcgtcga acggccccgg
      841 gcgaggagca actgtaaccg tatttacgac ccggtcacgt catgaatgcg cgggccgggg
      901 tgtcccttcg ggcgatgggc cgtatccgat tgacgattcg ctctttgtat cggtggcctc
      961 ccctccatcc gaatccacat ccgaattcac catcgaacgc cttgtcgcat atccgtccga
     1021 aggaaaagcg ggtaatcgaa cggtgggtcc gccgtcacgg cgggtgacgg cgtcgcggtc
     1081 gaggccgcgg acacctgcgc tgttgaacgc ccgctccggg cgtcatcggc ctcgcggggc
     1141 aacccgtcgg ggtggttttc cacggccctg accgccatcc gtgtgcgcgg tccggaccag
     1201 tggttcggcc aatcattcgc ttgccggaaa catgggttca cccgttaggg gcaaaaccgg
     1261 ggggccgtgt ccgcgttgag gtgtaggtcg agtgatacac ccggtcagtg ccttatccca
     1321 aggcccatga ctttcccaat ctaggagtgc ttctccatgt cgcgtaccgc gaaggccctg
     1381 gtcatgtcca ccgctgccat tgccaccatt gccggcgggg ccggcgtcgc cgccgccgac
     1441 gccggcgcgc agggcgctgc caccaactcc cccggtgtcc tctcgggcaa cctgctccag
     1501 gtgccggtgc acgttccggt caacgtctgc ggcaacacgg tcaacgtgat cgccctgctg
     1561 aaccccgcct tcggcaacac ctgcgtcaac aagtagtccc cgcctcggcc ccggccgccc
     1621 ctgcccaggg ggccgccggg gctttgtgct gctccggatg gcgcaggcgg cgcgggcagg
     1681 cggttgcggg aggtgaaggg gccgcgcacg gtgagggaaa tgcgcctgtt ccagcgaagg
     1741 agaacccttt catgcgtgca cgcacaccgc ggcgactggc cgcagtggcc ctgtcgaccg
     1801 cgatcgtcat cgccaccgcc ggggccgccg cggccgaggg cgtccagccg ccgcgaccgg
     1861 tcgccgccga agccgcggtg ccgggttccg acgaggtgct ccaacaggtc aaggtgctgg
     1921 cggacctggg gggcgtgctc aagccggtca cggatctgct gaccgcagcg ctgggcggca
     1981 agtcgcccgc cgagatcacg gccctcgcgt ccggggcgac gtccgccctg gacgccgcga
     2041 agtcagcgac cccggcggcg ctcgtgccgg cgaagcccgc gaccccggcc aaccctgcac
     2101 tgcccgcgac cccggacaag cccgcgaccc cggccaaccc tgccgccgtg cccgcgaccc
     2161 cggccaaccc cgcgaccccg gccaaccctg cactgcccgc gaccccggcc aagcccgcga
     2221 ccccggccaa ccctgcactg cccgcgaccc cggccaaccc cgcgaccccg gccaaccccg
     2281 cagcccccgc cgcccccgcc acctccgtgc gcccggtcat gcccgcggcc ccggtcactc
     2341 ccacgtcgcc cgcgctgtcc gcgctgccgc tgagcgggca gccgcaggcc gccgggccgg
     2401 tggacgtcag ggccgacgcc gtcgccgtgc tcaagaagtc cgtcgacgac ctcgtcaagg
     2461 cggtcaccag cgccaaggcc gacggcgtcg tgccggcggc gacctccgtg gtcaccggcc
     2521 tggtcggtct cgtcgtcgcc accttggtcg gtgcgggact gcccgtgccc agcctcccgg
     2581 gcctgcccca gcctcccaag tccccggccg gatcgctgcc cgcggccccc gggctgcccg
     2641 cctgacccgt accgccccga tccggcaccc gcccggccgc gatgcggccg caatccgctc
     2701 ccgaggggtt tctcaaccgt ccaggtgtcg ttagccaagg cgaagcatcg caaagcgatc
     2761 agagatacgc gcggctccgc ccaagtgcgg cacgcgcggc ccattcggcg atcgaactcg
     2821 ccgcggaagg attgatgatg aagtcgatga aggtagccgc ggcggtcgcc ggttccctcg
     2881 cggtgatggg cgcggcggcc ccggccttcg ccgccggagg tacgcctccc atgcccccca
     2941 tgagcctcaa cggcggcctc gactcgctga ccaacgcggc gtcccacgcc cagttggccg
     3001 acgcggcgcc cgtcaacacc agcgcgctcg accccaagtc ggacggctcg gtgctgcacg
     3061 cggtgaccag tgccgcccac gacctcaaca agtcccacgg cgggtccggc tccggccgga
     3121 tgctcggcgg actgccgatc ggctgaccag ggtctcctgg accccgcctt cggcaacacc
     3181 cgcgtcaacg accgagcggg gccgggcgcg tgcgtgcccg gccgccgggc gccaagtggc
     3241 cgccggctcc cgggagttcg ggagccgcgg ccgcttccgc atgcgccggg ccggccgccc
     3301 ccacgcgtca ccccggccgc acccacgcgt caccccggcc gcccccacgc gtcacccccg
     3361 ccgcatacgc agagcccggt gcgtcccgcg aaggacgttt catccggatg agtgacagcg
     3421 gcgcagggct cgacccggaa tgtcctagag tcccggcatg acttcagcca gcagtgccgt
     3481 acagccgtcc agggccgccc tgttgggctc gctcatcgtc atcgcgtgga gtggcgaaca
     3541 ccccgacgaa tccggcgaca tgcccttcct catggcgtac cccctcggtg acggcgtcca
     3601 gggccccgag ggcgccgagg tcgcggcgcg ggcgttcctc gaggagatcg gcatgccgcc
     3661 gggcagtgtg gtcgaccaga gccacggcgg ctcgttcccg ctgaccctga tcgtgcaggc
     3721 cggccgggcc gtcctgaccc tgccgaccat gaccgcccag tgccccgcgc cgcccgagtg
     3781 gctggcggcc gccgagaggc gcggcaccgt ccagttcatc ttcgccaccc gctcctggcc
     3841 ggaggccgtg cccggcgtcg ccgtcaccga cgagcagttg cgggcgttcg cgggcgacga
     3901 ggccaccatc accaccgccg gccactgcct gctccccatc cgccgcctgc gcggctgagc
     3961 ccgccggacg agaacgcaac ggaagacgac accgatgccc ttccacggga cgctccagga
     4021 gccggctccg ctcaccgact cgtccggacc cccgccaccg cccagcaccg ccttcggcgc
     4081 cggccgcggc ttcgcccggc tggtcgtgct caccggcgcg gccggcctgc tggcctcctg
     4141 ggtcatcacc ctggacgagt tcgagctcct gcgtaatccg gacttcgtcc cggggtgcag
     4201 cctcaacccg gtgatctcct gcggcaccat catgaagagc gcgcaggcgt ccgtcttcgg
     4261 gttccccaat ccgatgctgg gcctggtggc gtacgggatc gtgtgctgtg tggggatgag
     4321 cctgctcggg ggcggccggt tcgggcgctg gtactggctg gcgctcaacg cgggggccgc
     4381 cttcggcgtc gtcttcgtcg gctggctcca gttcgagtcg ctgtaccgca tcaacgcgct
     4441 gtgcctgtgg tgctgtctgg cgtgggtcgc caccatcgtg ctgttctggc gggtcaccca
     4501 cctcaacgtg atcaacggag cgctgcccgc gccgggttgg gcgcgagagc tgtccgccga
     4561 gttcggctgg gcggtgccgg tggtgcacat cggggtcgtc gcgatgctga tcctgacccg
     4621 ctggtgggac ttctggacgc ggtgaggatg cgcccgagcg gacgcccggt cgcggaggcc
     4681 gaccccggct cgccccgcgc accggctggg ccaaccgcgt gaaacgcctc cggccgccga
     4741 cacgcccgcc cgctccgggc gttgacccca tcgaccagtc gcatggttga agcctccccg
     4801 ggccgtgcaa ccagtaccgg cccggggagc gccgacggcg ccgcgagcgt acggcggccg
     4861 tttcctgcgc ccgggggcct cgttgtaccc ggcatcggtc aaggagagcg gacgctcggc
     4921 gggccccgga acctggacgg tttgcggggc ccacgcatgt gccggactcg tccgcgcgag
     4981 cgagcacgag ggagacgccc atgaacgacg cgccacactt ctggagcgca cgccgcaccg
     5041 gccgcacccg cctgcgcagc cgcgcccccg aacccaccgg gcccggcgcg cccccgcccc
     5101 gtaccgcctg gcgcaccgcc cgacgcggcc tgctgcgcgc cctgttcgcc tcggcggccg
     5161 tcgccttcac cggcgccgcg ctctcccgca tcccctccgc cgcgccggcc ggtgccacgg
     5221 gccccgggcc caccgcgcgt gttcccgaga gcatgctctt cgacgagatg cacgccgggc
     5281 accgcatcca gggccgggcc ctccaggcgg acgggtccga ggtcgccgtg ttcgtggacg
     5341 accgccggct catgctgatg cgccgcgccg acggcaccta tctgagcgcc gtcgaccact
     5401 acgagtccta cgccaccgca cgcgaggccg cccgcgccgc cgcggccgag ctgggccgcg
     5461 cccggctggc cgccgtgccc gtgcacgcgg gccacgaagg gggagccgtc cgtggtgtac
     5521 acgcgtaaga accagcggaa cctgacgagc gccgagcgca aggcgttcgt caacgccgtg
     5581 ctcgaactca aacggcgtgg cacatacgac gcgttcgcgc gcacccacat cgacttctac
     5641 gtctccgacg gcgaccgcgg gctgcgcgtg gcgcacatgg cgccgtcctt cctgccctgg
     5701 caccgccggt tcctgctgga gttcgagcgg gcgctccaga aggtcgaccc gcgcgtcacc
     5761 gtgccgtact gggactggac gcgcgacagt tcggccgcct cgtccctgtg gggcgacgac
     5821 ttcatgggcg gcaacggacg ccggggtgat ctccaggtca tgaccggccc cttcgcgcac
     5881 gcccacggcc actgggacat caccgtcaac gtcaccgacg aacgcttcct cacgcgggac
     5941 ctgggccgcc ccaagaaccc catcaaactg cccaccgccg ccgatgtcgc ccaggcgctc
     6001 gccgacccgg tgtacgacgt ctccccctgg aactcgatga gcgggaccgg gttccgcaac
     6061 aagctggagg gctggaccaa ggcgtcgggc gacgcccgct tccgtacgca caaccaggtc
     6121 caccgctgga tcggcgggat catgctcggc ggcgccgccg tcaacgatcc cgtgttctgg
     6181 ctgcaccacg ccttcgtcga cagcctgtgg tcacgctggc aggccgccca cccgaagtcc
     6241 aagcgctatc tgccggacgt cccgccgccg ctgggcgacc tccagcacgg ccgggtggcg
     6301 gcgctccacg acccgatgcc gccgtggaac gtggcgcctg cggcgctctt ggaccacagc
     6361 cggatctacc ggtacgcctg acacggcgac ggcctcccgg ggggagaagt ccgggaggcc
     6421 gcaggcaccg tgggagcaga ggcccggccg gaccgtcacg aggaccgtcc ggccgggaca
     6481 gggaggcgtc agcccccgta gccgccgtgg tggtggagca ggtgggagtc gttgacgcag
     6541 gtgttgccga acaccgggtt cagcaggccg atgacgtcaa cggtgttgcc gcagaggttg
     6601 accgggatgt gcaccggcac ctgcaccagg ttccccgaga ggacgccggg ggagttggac
     6661 gcgacagcct cggcgccggc gtcggcagcg gccatacccg caccggccag tgccatggcg
     6721 cccgctccgg cgacgacggc ggccgtcttc gcgatacgag acatcaaagt tctccttgat
     6781 tggacacgcg accgcagaca cgcagtcgtc atgtcacttc aacgtgtcga ccggccatag
     6841 gtaacggaca ccaaggagca aatcggttcc tccctgagcg aaccggggac ggccgccccg
     6901 cgcgcacaag cgcttcactc ctcgccgtac ctcccgcgtg aggagcgccg ggacagggcg
     6961 accgccgccg cccccgtgac gaccgcgccc acgctcaggg cgccgagcag cgtggcgttg
     7021 gcgtcggcgc cggtgtccgc cagggtcggc ggagccgcgc cggggcgcac tggggcgccg
     7081 ccgggcgcgt gcggggccgt gtgcggcgct gtgtggggcg cggaggcggg cggcggggcc
     7141 gcgccgggac ggtcggtggc gtgcgccgcg tacccggtgc ccagcgcgga caccaggccc
     7201 gtgacgaggg cggcccgcgc cgcggaacct gagagcttgt acatgcctgc gacccttcaa
     7261 caggaaaacc ggagggggga tcagatgctg atacgcataa ttgggatccg cctcgcgggg
     7321 cccccggggc cacgcgagca ccaccgaagg gatcacccgc ccggcccatc ggccgccccc
     7381 gcacggctca gcgcgcggcc cgccgctcac cgcgcccggt aggcgtgcgc cgcctcgggg
     7441 tggtcggggc actcccagac gccgtgcggg cagtagtcgg tcagggtctg gtagacgggc
     7501 cggtagcggc ggaaccaggc cgtcatcccg cgcacgtacg gcgcgtcgtc cccgttgcgg
     7561 aagagtcccc actccgggta cgacaccggc ttgccgtgcc gggcggcgaa gtcgacctgg
     7621 gcgcgcagtc cgtacggctc ctcgacctgc tcgcggaagg acatgccggc gggctggtcg
     7681 taggagtcca tgccgacgat gtcgacgaag gcgtccccgg gatagcactc ggtccacgcc
     7741 accgcgtcgc gcccgcggtt cggcgcgaag tcgaagcgga agtgctgccc cgccaccgag
     7801 cgcatcgcgg tgaccacgcg ccgccagtac gcccgccagg aggccggatc gggagcgcag
     7861 cggtgcgtat aggtgacgcc gttcatctcc cacccgagga cgacgttggt gtcggcgagc
     7921 cggagggcga ccaggcgctc ggccagcgcg gtgaagtggc cgtcgaaggc gccgcgcgcg
     7981 ccctgtccga gcaggccgcg cacctcggcg tcgggcaggc cggcctcgtt gggggccagc
     8041 atcggcacgt tgaggacgaa gacccggtcg gtgcgctcgt ggcgccagcg ggcccagggc
     8101 gcgaggagcc ggggcgggcc ctcgatgccg ctccaggtgt cgcccggcag ataggtgtgg
     8161 ccggcccgca gccgcccctg gccgcgccac ttctcgaccg cagccagctt gacgatgccg
     8221 tccccgtcgg acccggtgaa gacgcccgcc gccgtcctgg ccccggtcgg catcgggccg
     8281 cgcgtccggt cgcccggcgg ctggaccagc gcggagagga gcagcacgag cgcgcacagc
     8341 gcggccttcc acgaggacgc ggcgttcgac gcccgacggc gtccggggcc ggtcccgctc
     8401 gcccggcgca ccgtgacctt cagtgggccc cggacgcgcc gtcgggctgg agggtgccgc
     8461 cgaacatggc gacaccggcg gtgagcgtct cggcgatctc gccccgcccg ccgagcacct
     8521 tcggctgccc gtactcggag acgctgccct gccccgcgcc cgtatcggcc gccgcgacac
     8581 cgggcgcggc gaggagcagg agggatgcgg cggcggtggc ggctcggagg cggcgctgtg
     8641 tgttcatgcc cggtacaacg ccccgcgcgc ggcgagggta cgcgggcggg gccgggcgcc
     8701 ggttctcagg gcttggccgc atcgaaggtg aagtactgcc tgcggacgcg gtggtcgaag
     8761 ttggacgtgc cgagttccgg ctcgccgagc gcgcgcacgg ccagcggccg ggtgagcagt
     8821 tcgcgcagga cggccttgat ctccaggcgg gccagatggg cgccgagaca gtagtgcggg
     8881 ccgccgcccc cgtatccgag gtgcgggttg gggtcgcggg tgatgtcgaa gacgtccggg
     8941 tcggtgaaga ccgacgcgtc acggttggcg gatgcgtaca ggagcatcac cttgtcgccg
     9001 ggcagaaagg tgtggccgct cagggtgtag cgcgtggtga cggtgcggcg gaactggatg
     9061 atgggcgtcg agtggcgcac gatctcgtcc acggcgccgt ccgcgtaccg gtcgaagtcg
     9121 tcggtcagca gggcgagttg gtccgggttg cgggtcagga gcaccagggc gtgagcgatg
     9181 gcgttgcgtg tcgtctcgac gcccgcgacg agcaacagcg agaagaacga gcccagttga
     9241 cggtacgtca gcgcctgtcc ctccacgtcg gcgcagacca gtgccgagat gaggtcgccg
     9301 gtggggtggc ggcgccgctc gcggccgagg cgcgccaccg tcagctccat ccgggccagc
     9361 gcccgcagcc ccttgcccgg gctcatcagg cgggcaccga gaccacgccg taccccggcg
     9421 tgctcggagg cccggtcgat ctggcgggcg atgcggcgcc ggtcggcgtc cggcacgccc
     9481 agcatcgcgc agatgacctc gaacgacatc cgggaggcca ctgaggagac gaactcatcg
     9541 ggccgctcgg cgaccatgtc gtccacgatg cgcacggcga gctcacggat gtgcgtctcg
     9601 gtggcggcca gcaggcgcgg ggtgaaggcc tgctgcacga tgcggcgcag ccgcgcgtgg
     9661 tcggcgccgt ccaggttgac catcgagtca ccgaacagcg tccgcaccca gcgcgccggc
     9721 tcgggcgagg tgaccccggg cgcgctcgcg aacacccggg gcagccggct cgccttgagt
     9781 acgtcggcgt gccggaccag cgcgtagaaa ccctgctcgg cgcggcgggg ggtggagggg
     9841 cgttcggtga agaacacggg gcgcggctcg tgccgcaact ccgtgaagcg tgccaggcgt
     9901 tgagcggccg gcagcttcca gaacgccggg ttcgcgaggt cggcgcaggc gtcgctgggg
     9961 gccgggatgg tccgggtgtg ggtcacgctc gtaccgttct gaccgccgcg cggctctggg
    10021 tcgacactgc aaggacgctg ggggacgggg attcgggcgg ggtcagctca tcagctcgcg
    10081 gccggccttg accgcgtcct tggccgcctt gaccgcgtcg gtgccggcct tcacgccgtt
    10141 cttgacggcg gtgaccttct tgcccagctt gtccccgacg gcgctctcgg cgacgggctt
    10201 gacctgggcg cccgcggcgc tggtggtggt ggccgccttg ctcagggtgt tgcccaggtc
    10261 gagggcgtgc gcggcggggg agagggcggc cgcgatggcg gttccggctg cggcggcggc
    10321 gaggtatcgg cgtacgttca tgtcggctac aacgcatgag ccgggccaag ggcacgcccg
    10381 gggggcgcgc ggcgcgcgaa cgggctccag gttgctgcaa gcaggggaac tttgcagtga
    10441 taccgccgcc gggatcgttc tagcagaacg acacggccga agaggccagg gaaggaaaga
    10501 acatccatgg gaatcacctc acgcgcgg
//
