LOCUS       NZ_CP032698            23629 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2139805
            Orig. end                         :: 2163434
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23629
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /product="RRE-containing"
                     /region_number="15"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..23629
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..23189
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23189
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13189](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13189)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    70..84
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     misc_feature    574..591
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            complement(691..2067)
                     /locus_tag="DWB77_RS09505"
                     /old_locus_tag="DWB77_01909"
     CDS             complement(691..2067)
                     /GO_function="GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985908.1"
                     /locus_tag="DWB77_RS09505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01909"
                     /product="phosphomannomutase/phosphoglucomutase"
                     /protein_id="WP_120720831.1"
                     /transl_table=11
                     /translation="MADLSRIFKAYDVRGVVPDEWDDTVAELLGAAFAELTGATCVVVG
                     HDMRPTSPRLARAFARGAVARGTDVVSIGLCSTDGLYFASGSLCVPGAMFTASHNPARY
                     NGVKFCLEEAAPLNGNLSLDTVRALAEQWMESQPPVSTRRLGTVVVRDVLFDYADFLRA
                     TVDLSDIRPLKVVVDAGNGMAGLTVPAVLRGLPLDVVPLYFELDGTFPHHPANPLDPKN
                     LLDLVQKVREEGADLGVAFDGDADRCFVVDERGEAVPPSALCALIADRTLKRSPGATVI
                     HNLITSRAVPEIIAEAGGTPVRTRVGHSFVKAEMARTGAVFGGEHSAHYYFREFWNADT
                     GMLAALHVLRALGKQSDPLSAVMARYSRYQALDETNYRVEDPAAAIARVKDRAAGLFDD
                     LVTLEEVDGLTVTSTHGWWFNLRPSNTEPLLRLNVEADTQERCVRIRSAVEGLLLPHAA
                     "
     gene            complement(2472..3077)
                     /locus_tag="DWB77_RS09510"
                     /old_locus_tag="DWB77_01910"
     CDS             complement(2472..3077)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071834.1"
                     /locus_tag="DWB77_RS09510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01910"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_246033478.1"
                     /transl_table=11
                     /translation="MSSRSEQTRNRIYQAALEEFAQYGVSGARVDRIAREAKANKQAIY
                     LYYDDKEKLFTLVLGRALEELAEAVPAPAESDDIATYIDRLFTYHKEHPAILRLLLWEA
                     LEHPGVPVPDEAARTQHYQHKAHALGKASGIGGSTLPELDPQALLLVFTALVGWPLAIP
                     QVTRMIMGDGPEAMDRIKAASIAVAQAVTGTAQESDPA"
     gene            3254..4063
                     /locus_tag="DWB77_RS09515"
                     /old_locus_tag="DWB77_01911"
     CDS             3254..4063
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012472.4"
                     /locus_tag="DWB77_RS09515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01911"
                     /product="aldo/keto reductase"
                     /protein_id="WP_120720833.1"
                     /transl_table=11
                     /translation="MDLRPLGHIGPQVPCVGLGTWRRFDLPRPQEYLARQIVELALENG
                     VRVFDTAPVYGRAEEVLSRALSAHRDRAYVATKIWAGERHTGRRQFERQLHLFQGRVDL
                     LQLHHLIGWRTHAEWMQQERERGTIGQLGLTYWRDRAFGGGTASELEEAMRTGVFDVIQ
                     IPLNPVERDMEERILPLAKELGIGVMVMRPFAEGSLLSSSRRAVPPKETGCATASEALL
                     RWGLSDARVAVTVPATLDLGHLIANTAAGSAPLLDEEQRAAIAALYR"
     cand_cluster    3348..23629
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    3348..23629
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[13347:13629](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(13348..13629)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     gene            4150..5391
                     /locus_tag="DWB77_RS09520"
                     /old_locus_tag="DWB77_01912"
     CDS             4150..5391
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="DWB77_RS09520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01912"
                     /product="MFS transporter"
                     /protein_id="WP_120720834.1"
                     /transl_table=11
                     /translation="MSHSDTASAQAKAVVGRPAAPPVRPLLFLVMAICSGATVANVYLA
                     QPLLELFARGLGISSASAGTVVTCAQFGYAGGILFLVPLGDVRRRRPLLSAMIAATTVL
                     LLLAAAAPGLSVLAAAAALIGGVTVIPQVLVPLASELAPPERRASVVGNVQIGLMTGII
                     GSRVIGGLVGEALGWRAVYVLAAALTALTGLVTLLLLPKEGPRTGMPYGQLLASLPRLL
                     RQEPALRHSCVLHGTLFGAYSATWTTLVLVLTQEPYGYSSATAGLFGLLGLSGAFAAPW
                     AGRFIDRRGPGPIITAALVLALVSAGAYALGGSTLAFMIAAVLLVNVAVQWSQIANQAR
                     IFSYLPEARSRANTVYMVAVFLSGAIAAALASACYGSYGWSGVCAVQALLALGGLLALP
                     AMRRYDLRHAGATA"
     gene            5447..5830
                     /locus_tag="DWB77_RS09525"
                     /old_locus_tag="DWB77_01913"
     CDS             5447..5830
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014220.4"
                     /locus_tag="DWB77_RS09525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01913"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_120720835.1"
                     /sec_met_domain="PF07366 (E-value: 1.8e-06, bitscore: 26.5,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPAMPKSVHQFFTASQAGDADAWADSFAETATFHDPVGTDPLE
                     GREAIRAFIKSVIPNFDPFLGLTPLEAHTVGNFVAVSWRGAAVSLDGKPTNWSGINVYE
                     IDENGLIAEAKAYFNSAVFAAQL"
     misc_feature    5475..5490
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(5904..5924)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.63"
                     /tool="antismash"
     gene            6011..7348
                     /locus_tag="DWB77_RS09530"
                     /old_locus_tag="DWB77_01914"
     CDS             6011..7348
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037627.4"
                     /locus_tag="DWB77_RS09530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01914"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_120720836.1"
                     /transl_table=11
                     /translation="MIETIIEKTTPLSLTSHGVQVKLLGVPEILVDDQPVPLRGETARR
                     VLCHLLLASPRAIPNQRLIESVWGGEEPDSAMEQIRKIVSKLRRDLPGGRDLITTELGG
                     YRITLAPEQLDLTVWTNAIQDVHQLIEAGDHHAAFEKLSLALDLWRGPALDGLDGQPFA
                     NEAVALHEERLNALETWCRLAMNELPISTVIAKIRREISQHPLQERLWDTLMRLLADNG
                     RPLEALNEYSNLRKVLAQSLGVSPSPRLQDTYRRLELMANGETARPNLRQTTERTAAPP
                     HTPKIPVWIKELLRGQEPNPAYVSDKYWNIVHRNQAMARWFPWLQGPDANLMTWALTNP
                     SARRVLGDWEDHAAVYLGMIDRALRQNPDDAALRSLSATLSEADSLPTTVRDQPVDVAT
                     REGHHYTLNLPHITPEPVNVVSHILTPHGHGELRVVLLTSPQEPAA"
     misc_feature    6013..6028
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.9"
                     /tool="antismash"
     misc_feature    complement(6022..6035)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    complement(6022..6036)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.37"
                     /tool="antismash"
     misc_feature    6044..6046
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6269..6271
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6710..6712
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7470..8159)
                     /locus_tag="DWB77_RS37675"
                     /old_locus_tag="DWB77_01915"
     CDS             complement(7470..8159)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014299.4"
                     /locus_tag="DWB77_RS37675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01915"
                     /product="hypothetical protein"
                     /protein_id="WP_162952485.1"
                     /transl_table=11
                     /translation="MIDIPVPLATGPKPERGVLVSFSGVDGSGKTTSIRRLKGTLRRNG
                     YRVRVFKLPSNECKKLRLFTEYKKDPLTAEPEGRVDIFSMFLAVTGDRLNTIRTKILPL
                     LDAGYAVIVDRYLYSALCEAVISSSGLTPTQWRVVSDIISEFPTPHVAFFTRVSFIEAR
                     KRINAREAERDDYVDPLLFNARIDAFEIVRSKFDGVLVDTALDEHSCFKIVSREVGRHV
                     LNQPARA"
     gene            complement(8156..9067)
                     /locus_tag="DWB77_RS37680"
                     /old_locus_tag="DWB77_01916"
     CDS             complement(8156..9067)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS37680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01916"
                     /product="hypothetical protein"
                     /protein_id="WP_162952486.1"
                     /transl_table=11
                     /translation="MPKAVIDVNVRYLDQDLREEYLRNLSLSDYLYQEPPTGLPRLIER
                     DYVKPEFFDWAFSKIEEAGFDPKEVDLRYASIDVRLDPIRESGPPLSFPFMINSAFTYN
                     GLNIHGPFVAGHQAGISMVQSLSEVKYARFNLPPHLDGVFTSDHQTSVIAHSVNGIRTA
                     PGVDGLIAALPDRGRDPEMFRKSNIARVLTGGHITDAAYDREPGTIWPGNPLRGVPFKI
                     TPEVYGGNAPLYANDFTYYSFFRPELHDELLRDARFLRLIDVIRRMGPSFKANRPNASE
                     GLLFNPQRNMQFITELITRSAK"
     gene            complement(9109..9966)
                     /gene="nadC"
                     /locus_tag="DWB77_RS09540"
                     /old_locus_tag="DWB77_01917"
     CDS             complement(9109..9966)
                     /EC_number="2.4.2.19"
                     /GO_function="GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA]"
                     /GO_process="GO:0019363 - pyridine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="nadC"
                     /inference="COORDINATES: protein motif:HMM:TIGR00078.1"
                     /locus_tag="DWB77_RS09540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01917"
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="WP_216826841.1"
                     /transl_table=11
                     /translation="MRNGKNMLELPVIRELVSRCLIEDLGRGDTTTDACVSPEAEGRAL
                     MAAREDLVFCGGALVREVFAQLDPRVQVEQLCREGERLTAGKAAVLLTGPAQSLLKGER
                     LALNFVQRMSGVATLTRSFVDALTPGSGTRITDTRKTTPGLRIVERYAVRCGGGHSHRS
                     DLGAAVLIKDNHVAAAGGITAAVTRSRAVATHATRITCEVDTLEQLREAIEVGVDIVIL
                     DNFTDEQIATAVEFTDGRAVIEVSGSVSRERIKAISALGVDIVSIGALTHSARAVDLGL
                     DWTA"
     gene            complement(10001..13189)
                     /locus_tag="DWB77_RS09545"
                     /old_locus_tag="DWB77_01918"
     CDS             complement(10001..13189)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="DWB77_RS09545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01918"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_120720839.1"
                     /sec_met_domain="DUF4135 (E-value: 1.4e-88, bitscore:
                     296.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.4e-36, bitscore:
                     122.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDAFLDDARWWAGLTPTERRTAGGFEPDPEERERGTARVRLWQE
                     GLLVPGLRVEQDVLAARWGLAPDRLALLAAETPQELKRRLPGAPDWVPVLVDAWQRFAG
                     SALPALAADAEDVDVPLDWLGPLAAWAREELRGRLGAAGQLPDSHPLFTPDTDTLRTMV
                     RRTLVLEINAARLEGRLDGASPEARYEAFGESLRDPERALDLLAGHPVLARGLVGHVRR
                     WTDVRAEFAERLSADLPELRERFAVSGEGLKDLAGLTFGAGDAHRGGRTVTLVAFRDGS
                     RLVYKPRSLAVDTHVNRLLRWINDRGARHPLGTNDLLERPDYGWSAFVTAAPCAHADAF
                     RRFAWRLGAHLALFHVLGCYDMHLENLIAAGEHPAFIDLEAMFHTESATTSDADADPVD
                     LLLRASVLAVGLLPQRVVKGDGSGVYAMEISAMAGGAAPGEYEIRPDIVLAEGGTDRMR
                     IVRRRRPVPESGNRPVLDGRPADPSAMLPGLIEGFEECYRLLFAGREDLLRELEAFADD
                     DVRTVLRNTSTYRAVLEEAWHPDLLGDGLDRAYLLEALDPDAQGDAVVLASELGQLARG
                     DVPVFTAKPSGTALFDDEGVTLAKGFFRQSGLDTARRRLASLSEEHLRDQLWFVHASLA
                     TRELGGHAQEEGLAHEGGLAQEEGPAQENGLAQEQGPAQNGGSAREARVEVGPHLRQDV
                     DPDTALAAASRIGDQLLASVRHGGDGVVEWANLNLVGDRYWVVGPSGLGLYSGVTGIAL
                     FLAELAAATGIDRYERQARDVVAALADPDGMPEPEDLRALPVGGYEDLCGVMLLLDRVG
                     RLWEDPALLDAARSLVPAVRQNLDDDESFDIVGGAAGTALALISLHATRPEESTRAAVR
                     RAGEILLDHAPTRQGVHGFGHGQAGRAYALSAIGELTGEPRYAEAASRALAENDRAAAR
                     TGPGVNAWCRGSAGTLLATARMRGFAGRPELSAVREGLRAGVGNDSLCHGTLGLAHALL
                     TAGERSGDRALVEEARRAATGVAHRVLAGDVRTGVPRRLWVPGLMNGAAGIGYGLLRIA
                     LPDRAVPDVLLLGT"
     gene            complement(13215..13355)
                     /locus_tag="DWB77_RS37685"
     CDS             complement(13215..13355)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03898.1"
                     /locus_tag="DWB77_RS37685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_162952487.1"
                     /transl_table=11
                     /translation="MSEPTAADVIRAWRDPLFRAALDDRARAALPPHPAGDIEVPGLDR
                     A"
     gene            complement(13348..13629)
                     /locus_tag="DWB77_RS09555"
                     /old_locus_tag="DWB77_01919"
     CDS             complement(13348..13629)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="DWB77_RS09555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01919"
                     /product="PqqD family protein"
                     /protein_id="WP_120720841.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.6e-10, bitscore:
                     38.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.4e-13, bitscore: 48.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-07,
                     bitscore: 30.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAGPVTAESIPSVRPDIRVRKIRGTLVVAVPEQAFELAETTAF
                     IWKRIDGVLTVGGIGELLAREYEIDVETAVEDTIEVLSELVEYGAVRV"
     aSDomain        complement(13354..13521)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DWB77_RS09555_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.50E-10"
                     /identifier="RREFam002.1"
                     /label="DWB77_RS09555"
                     /locus_tag="DWB77_RS09555"
                     /protein_end="92"
                     /protein_start="36"
                     /score="30.1"
                     /tool="antismash"
                     /translation="FELAETTAFIWKRIDGVLTVGGIGELLAREYEIDVETAVEDTIEV
                     LSELVEYGAVR"
     aSDomain        complement(13369..13608)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DWB77_RS09555_PqqD_RRE.1"
                     /evalue="9.80E-13"
                     /identifier="RREFam006.1"
                     /label="DWB77_RS09555"
                     /locus_tag="DWB77_RS09555"
                     /protein_end="87"
                     /protein_start="7"
                     /score="38.7"
                     /tool="antismash"
                     /translation="TAESIPSVRPDIRVRKIRGTLVVAVPEQAFELAETTAFIWKRIDG
                     VLTVGGIGELLAREYEIDVETAVEDTIEVLSELVE"
     gene            complement(13629..14399)
                     /locus_tag="DWB77_RS09560"
                     /old_locus_tag="DWB77_01920"
     CDS             complement(13629..14399)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS09560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01920"
                     /product="hypothetical protein"
                     /protein_id="WP_120720842.1"
                     /transl_table=11
                     /translation="MSEDRPHQLEQLRALDLLPESWVCVFEAGSLVRGWGNASSDVDLY
                     VISEEPWTGKGASRHPVPLVPSVVLGEETFVDAMRWDIRYWTRGQVEQVLAKVTWQAFE
                     QGAEELALREVQLLDRLAFGAAAGGQELLSHWRVQAEESAFRSIHAARILNMADSRVED
                     AVGQLEAGDVDSAVLSARAAFHYTVDALLASEGECGPGEKWRARRLRAAAPAVLPYDTY
                     WALETMRSLDPAQPAAWINEVLSVCRGIAMEVDI"
     gene            complement(14392..16614)
                     /gene="asnB"
                     /locus_tag="DWB77_RS09565"
                     /old_locus_tag="DWB77_01921"
     CDS             complement(14392..16614)
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01536.1"
                     /locus_tag="DWB77_RS09565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01921"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_120720843.1"
                     /sec_met_domain="GATase_7 (E-value: 7.9e-43, bitscore:
                     144.0, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.6e-63, bitscore:
                     214.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGVARIDGGMLTPAADELLRDLACTLAHRGPDDQRLLREDQ
                     VGLAFTRLSLVDPEGGGQPLVSEDGSVVLIANGEVYNHRELAASLPPGARFKTRSDCEV
                     LLHLYQRDGLNFLDRVNGMFAVVLWDRKQNKLLFCRDRFGIKPLFYHRDRERIVFASEI
                     KALFTDPATPRRLDWSGALADYGMSSTPAFIHEPVNTWFEGIELAPAATVMEIDLKDGA
                     TREHRYWSLPGAAADSDASDEEYIERYRDLLAASVQDCAMADAELGLFLSGGIDSSAVA
                     ALAGQSGLRTFSVLTGATVLNGDAEWSHRAAHMLGVPNEQILFDGDRVPGIEEWKNLLW
                     LTETPLCSPEQFYKYELHRHARLRHPEIKGMLLGAASDEFNGGYSLNYTGEGGNWSDFI
                     TNIGALARRKALDSRPQLASWWQMSDLPLLKDEAAHAGLGVDAPDPYDAFIAWKYRSLQ
                     QYNVWHEDRTAAGNSVEARVPFLDHRLVELVASIPAARRENLLWDKRILRRAMVGILPE
                     ELINRPKVPFFHGEGQRHTYRTFTRMLAQGGDALLEEAFSSERARQFIHQDGVRESLRR
                     LERDPENGSVEHLLRLVNLGLLERMTADLPAPPSAAFSAATPEPVTFEYGDWDESEGQI
                     RALTMPRPPVDPAAVYALRDDTLLACVPAQPGIWYLLVDGACEFVLSEDEEPGLTALLR
                     SLDGETSLEKVLAGNGHTLAELKPLLEEVLDLGLVVEAAPKGADRV"
     misc_feature    complement(16770..16785)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     CDS             16860..16985
                     /gene="allorf_2156665_2156790"
                     /locus_tag="allorf_2156665_2156790"
                     /protein_id="allorf_2156665_2156790"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNYPTGMRPPWSPRSETETVTFAGPVPTCPQTRSVHVADGF"
     CDS_motif       16860..16928
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNYPTGMRPPWSPRSETETVTFA"
                     /locus_tag="allorf_2156665_2156790_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16929..16985
                     /prepeptide="core"
                     /locus_tag="allorf_2156665_2156790_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.60"
                     /molecular_weight="1814.0"
                     /monoisotopic_mass="1812.9"
                     /core_sequence="GPVPTCPQTRSVHVADGF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNYPTGMRPPWSPRSETETVTFA"
                     /leader_location="[16859:16928](+)"
                     /alternative_weights="1832.0"
                     /alternative_weights="1850.1"
     gene            17296..18558
                     /locus_tag="DWB77_RS09570"
                     /old_locus_tag="DWB77_01922"
     CDS             17296..18558
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="DWB77_RS09570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01922"
                     /product="MFS transporter"
                     /protein_id="WP_120720844.1"
                     /transl_table=11
                     /translation="MNLRKFQAFSGPLSDSRFRVLWFGQTLSYAGSAIFPVALTLALVQ
                     GVGSATDLGLVLASAAVGEALFLLVGGVWADRLPRQKVMIAADSIRCVAHVFIGLRIVS
                     GQAGLAELMLASACVGAATGFFLPASSGLVPSTVTPELLQRANAVMAVSRRSAMMLGPA
                     AATTIALTIGPGWAMVIDGATFAVNALMLSRLRVGHVAAPRESFLKELREGWGEIRERT
                     WLWSNYAAHGCWNLSRTVYFTVGAATVISGLGGEVAWGIIAQGATVGALTGALVSLRVR
                     TSRPLVVINICLSLGAIPLALIALGAPTALIAVGAGVMAFALGLMGTLWDTAVQQQIPT
                     DRMSRVSAYEWLLSSALIPLGMALAGPLAGLVGAKAALYGAAALMAVSSLGVLAIPEVR
                     RLGRAHGPVVAEEADPISAGA"
     gene            18573..19577
                     /locus_tag="DWB77_RS09575"
                     /old_locus_tag="DWB77_01923"
     CDS             18573..19577
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AurF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF023015.4"
                     /locus_tag="DWB77_RS09575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01923"
                     /product="diiron oxygenase"
                     /protein_id="WP_120720845.1"
                     /sec_met_domain="AurF (E-value: 2.6e-28, bitscore: 97.8,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKTTHRAPLRQTLTRLTDPESPVAAQYRSRFALWDARASVRVKP
                     PRLLTPAEPGRLYFPPELMPVVAHPLVRSRPYEVTERVLTQRLHQYLYFTTELEQVAVM
                     PVTMDISRGRSGLDLPAAMREDAFKITTDEAWHAQFSDDLSRQVQARTGFDACLPDRPA
                     FIDRLDRIRAGMDHDLRGAADLAFSVVSETLISSILSDLPRDKRLPEAVRELVQDHAED
                     EGKHHAYFRSLLEFFWHALDAPARRRMGALVPELITAFLEPDYLAIALTLGDAGFSAEE
                     AEEILTDSHPADATRAAIGRAAQATTRYFTEVGALDTPSTHEAFASAGLLTTN"
     gene            complement(19924..20310)
                     /locus_tag="DWB77_RS09580"
                     /old_locus_tag="DWB77_01924"
     CDS             complement(19924..20310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007261737.1"
                     /locus_tag="DWB77_RS09580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01924"
                     /product="hypothetical protein"
                     /protein_id="WP_120720846.1"
                     /transl_table=11
                     /translation="MSSKRSKNPALPVLDDAYRLESVKGAEESTRDLAARLATTELRRA
                     SHPGRITWEPVDQAEPVPVPPTVVDGDGDLWLRDRGTGTWTMPEFNPKEFPARCGEVLT
                     WTQLAREFGPLTALADDRRMGGRR"
     gene            complement(20451..21590)
                     /locus_tag="DWB77_RS09585"
                     /old_locus_tag="DWB77_01925"
     CDS             complement(20451..21590)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126237.1"
                     /locus_tag="DWB77_RS09585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01925"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_120720847.1"
                     /transl_table=11
                     /translation="MNHAIRRASELTLDETTVSALRAALKNTADEIVQAIIDEVPPYAN
                     ALSGRMGGIIRRAVRTALGHHLDLASGNATGGDAGDAAYELGRGEVREGRSMDALLSAY
                     RVGARVAWRCLATGAVPAGLPAAEVAKFAELTFAYIDELSAASAAGHADELAAQGRAQE
                     RHLEHLARDLLADASPDVLRASVQRAGWQPPVSLTAVLLPAAQARPAYRTLHPSTLVLD
                     DLPDALGVLLVPDADRAHLLRQLNHRAAVVGPARPWTRASASYARAVRARSLSADIRDT
                     EDHLPELVLSADADAFADLRARALAPLRTVPAATARRLEETLRAWLLHQGRRDEVAKAL
                     FVHPQTVRYRMSQLRELFPDLASPQCVLELTLALGLQVR"
     gene            21677..22732
                     /locus_tag="DWB77_RS09590"
                     /old_locus_tag="DWB77_01926"
     CDS             21677..22732
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262664.1"
                     /locus_tag="DWB77_RS09590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01926"
                     /product="ferredoxin reductase"
                     /protein_id="WP_120720848.1"
                     /transl_table=11
                     /translation="MRSAALRGRAWKLLETVTTPLLPSDYLDLVSPLRAGAELRGRIEA
                     VHPETGDAATLVIRPGRGWRGHTAGQYVRIGVDVEGVRLWRAYSLTSPTDRRDGRVTIT
                     VKAIPGGKVSNHLVRRAQPGTLIRLDQATGEFVLPKPKPAKVLYLTAGSGITPVMGMLR
                     DTEFDDVVMVHSAPRPQDVIFRNDLHDLVAEKKLRLTELHTATDGMLDIARLDELVPDW
                     AERETWACGPAGLLDAAEAHWTEQGVQERLHTERFRPSVVVSGDGGEVTFRTTGKIVDA
                     DGATPLLDVGEEAGVLMPSGCRMGICYGCVTPLKAGAVRDLRTGEITEAEPGVLIQTCV
                     SAAAGPCDIER"
     misc_feature    23169..23183
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(23598..23611)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.57"
                     /tool="antismash"
ORIGIN
        1 gcgtcgtcac gaagagcgga atgaccttct ccgggaactg gtagggcccg tagttgttgc
       61 tgcaccgggt gatgctcacg ttcatgccgt gggtgcgggc gtaggaccgc accagcagat
      121 cggctccggc cttggcggcc gagtacggcg agttgggctc cagcgggcac tcctcggtcc
      181 acgatccctc ggcgatggag ccgtacacct cgtcggtgga gatgtggacg aagcgcgggg
      241 tgtgggcctg gagcgccgcc tccagcaggg tgtgcgtgcc gagcacgttg gttctgacga
      301 actgcgacgc gttgccgatg gagcggtcca catgggtctc ggccgcgaag ttcaccacgg
      361 cgtcgacgcc ggtgagcagc ttggggacca gggcttcgtc ggcgatgtcg ccctgcacga
      421 aacgcagtcg cgggtcgctc gacacggggg cgaggttggc gaggttgccg gcgtaggtca
      481 gcttgtccag gaccgtgacg tcggtgatgc ccgtgccgta gtggccgccg agcagattgc
      541 gtacgtaggt gctgccgatg aatccggcgc cgcctgttac caggatgtgc atggttgagc
      601 tcctcgattc ctcaggagga catgaccccg cgggcggacc ccaagggctg cgatgtccgg
      661 cagggcgaag acgtgacgcg atgaggggcg ttacgcggcg tgcggcagga gcaggccctc
      721 gacggcgctc cggatgcgca cacagcgttc ctgcgtgtcg gcctcgacgt tgaggcgcag
      781 cagcggttcg gtgttggagg ggcggaggtt gaaccaccac ccgtgggtgg aggtgacggt
      841 gagaccgtcg acctcctcga gggtgacgag gtcgtcgaag aggccggccg cgcggtcctt
      901 cacccgggcg atggcggcgg ccgggtcctc gacgcggtag ttggtctcgt cgagcgcctg
      961 gtagcgcgag tagcgcgcca tcaccgcgga gagcggatcg ctctgcttcc cgagcgcgcg
     1021 cagcacgtgc agtgccgcga gcatgccggt gtcggcgttc cagaattccc ggaagtagta
     1081 gtgggcggag tgttcgccgc cgaagaccgc tccggtgcgg gccatctccg ccttgacgaa
     1141 ggagtggccg acccgggtcc tcaccggtgt tccgcccgct tcggcgatga tctccggtac
     1201 ggccctggag gtgatcaggt tgtggatcac cgtggcgccg ggcgaccgct tcagcgtgcg
     1261 gtcggcgatc agggcgcaca gggcggacgg cgggacggcc tcaccgcgct cgtccacgac
     1321 gaagcagcgg tcggcgtcgc cgtcgaaggc caccccgagg tccgcgccct cctcccgcac
     1381 cttctggacg aggtcgagga ggttcttggg gtcgaggggg ttcgcgggat ggtgggggaa
     1441 ggttccgtcg agctcgaagt agagcggcac cacgtcgagg ggcagccccc gcagtacggc
     1501 gggtacggtc aggccggcca tgccgttccc cgcgtccacg accaccttca gggggcggat
     1561 gtccgagagg tcgaccgtgg cccgcaggaa gtcggcgtaa tcgaacagca catcacgcac
     1621 cacgacggtg cccaaccggc gcgtggacac cggcggttgg ctctccatcc actgctccgc
     1681 gagcgcccga accgtgtcga gggacaggtt cccgttgagc ggagcggctt cttccagaca
     1741 gaacttcact ccgttgtagc gcgccggatt gtgggaagcg gtgaacatcg cgcccggcac
     1801 gcacagcgac ccggaggcga agtagagccc gtccgtcgag cacagcccga tggacaccac
     1861 atcggtgccg cgggcgaccg cgccccgggc gaaggcccgt gcgagccgcg gagaagtggg
     1921 gcgcatgtcg tgtcccacca cgacgcaggt ggctccggtg agttcggcga aggcggcacc
     1981 gaggagttcc gccacggtgt cgtcccactc gtcggggacg acaccgcgta cgtcatacgc
     2041 cttgaagatc cgtgacagat ccgccattgc cctagctccc gaggtagtcg ctcaccggcc
     2101 acctcatgac agcgcaggct ccttcctttc tcctaccgcc gaaataccgc gaggggttga
     2161 caccggcgcg aagagcgtca agcccacccg cactcgtcgg gagggccggc gtccggttct
     2221 gttccctcgg atccggtcac ctgaaaggct ccggcgggcc cgccgcatcg ccgaaacccg
     2281 tgcggatacg gcgccttcgg ccgcgtcggg ccacgactcc acgcttcctg ccacgggagg
     2341 ggtgtgacag gccggcgcgt cgaggatggc ctgattcggc gccatggggc gcggcgcggc
     2401 cggagcccgg ccccggcacg aggggcgcgc gggccgcccg aaggcgtccg gccgagcgca
     2461 aggatccggc ctcaggccgg gtcggactcc tgcgcggtgc cggtgaccgc ctgggcgacg
     2521 gcgatcgagg cggccttgat gcggtccatc gcctccgggc catcgcccat gatcatgcga
     2581 gtgacctggg gaatggcgag cggccacccc accagggcgg tgaagaccag gagcagggcc
     2641 tgcgggtcga gctccggcag ggtgctgccg ccgatgccgc tggccttccc gagcgcgtgc
     2701 gccttgtgct ggtagtgctg ggtgcgggcg gcctcgtcgg ggaccggcac gccgggatgt
     2761 tccagggcct cccagagcaa cagccggaga atggccggat gttccttgtg gtaagtgaac
     2821 agccggtcga tgtaggtggc gatgtcgtcc gactcggcgg gcgccggcac ggcttccgcc
     2881 agctcctcca gggcccggcc caggacgagc gtgaacagct tctccttgtc gtcgtagtag
     2941 aggtagatgg cctgcttgtt ggccttcgcc tcacgtgcga tgcggtcgac cctggcaccg
     3001 gagaccccgt actgggcgaa ttcctccagt gccgcttgat agatccggtt cctcgtctgt
     3061 tctgatcgcg agctcacccg gcagctcctt cctcgtccgg caagtgtcac atgcgagcca
     3121 ccccgtcccc cgcccaccag cggcgacggg tccgcgcggc cccgaactaa accatccagt
     3181 tgatttaaac caactggttg atgtagaaca ggagcgtagc ctccccgagt ccctggaagt
     3241 gaggtcaacg gctatggacc tgcgtccact tggccatatc ggaccccaag tcccctgtgt
     3301 cggcctaggt acatggcgcc gattcgatct cccccggcca caggagtacc tcgcccgcca
     3361 gatcgtggag ctggcgctcg aaaacggcgt ccgggtcttc gacaccgccc cggtgtacgg
     3421 ccgggccgag gaggtcctca gccgggcgtt gagcgcccac cgcgaccgtg cctatgtggc
     3481 gacgaagatc tgggcgggcg aacggcacac cgggcggcgg cagttcgagc gtcagctgca
     3541 cctcttccag gggcgcgtcg atctgctcca gctccaccac ctcatcggct ggcggaccca
     3601 cgccgagtgg atgcagcagg agcgggagcg cggcaccatc ggccaactcg gcctcaccta
     3661 ctggcgcgac cgcgccttcg gcggcggcac ggcgagcgag ctggaagagg ccatgcgcac
     3721 cggcgtcttc gacgtcatcc agattccgct caacccggtc gagcgcgaca tggaggagcg
     3781 gatcctgccc ctggccaagg agctcggcat cggcgtgatg gtgatgcgcc ccttcgccga
     3841 gggaagcctg ctctcctcct cccggcgcgc cgtgcccccg aaggagaccg gctgcgccac
     3901 ggcctccgag gctctgctgc ggtggggcct ttcggatgcg cgcgtcgccg tcaccgtgcc
     3961 cgccaccctc gacctcgggc atctcatcgc caacacggcc gcgggttccg cgccgctgct
     4021 cgacgaggag cagcgcgccg ccatcgccgc gctctaccgc tgagaaccca aggacccggg
     4081 gtccgcccct gcgtccgtcc ctccgttcgc tcctccgtcc gctcctcccc tcgcctccaa
     4141 ggacttccca tgtcgcattc ggacaccgcc tccgcgcagg ccaaggcggt ggtcggccgg
     4201 cccgccgccc cgcccgtgcg cccgctcctc tttctggtga tggcgatctg tagcggcgcc
     4261 acggtcgcca acgtctatct cgcccagccg ctgctcgaac tcttcgcccg agggctcggc
     4321 atctcctccg cgtccgccgg aaccgtcgtc acctgcgccc agttcggcta cgccgggggc
     4381 atcctcttcc tggtgccgct cggtgacgtc cgccgtcgcc gccccctgct gagcgccatg
     4441 atcgccgcca ccacggtcct gctgctcctc gcggccgccg cgcccggcct gtccgtgctg
     4501 gccgcggccg cggccctgat cggcggcgtc accgtcatcc cgcaggtcct ggtgccgctg
     4561 gcctccgaac tcgcgccgcc cgagcgccgc gcctccgtcg tcgggaacgt ccagatcggc
     4621 ctgatgaccg gcatcatcgg ctcccgtgtc atcggcggcc tggtcggcga ggcgctgggc
     4681 tggcgcgcgg tgtacgtcct ggccgccgca ctgaccgcgc tgaccggtct ggtcacgctg
     4741 ctcctgctgc ccaaggaggg gccccgcacg ggcatgccgt acgggcagct cctcgcctcc
     4801 ctgccccggc tgctgcgcca ggagcccgcg ctgcgacact cctgcgtcct gcacggcacg
     4861 ctgttcgggg cctacagcgc gacctggacc accctggtgc tggtcctcac ccaggagccc
     4921 tacggctaca gcagcgcgac cgccggactc ttcggactcc tcggcctctc cggcgcgttc
     4981 gccgctccct gggccggccg cttcatcgac cgccgcggcc cgggccccat catcaccgcc
     5041 gcgctcgtcc tcgcactcgt ctcggccggc gcctacgccc tgggcggcag caccctcgcc
     5101 ttcatgatcg cggcggtgct cctggtcaac gtggccgtgc agtggagcca gatcgccaac
     5161 caggcccgca tcttcagcta tctgcccgag gcccgcagcc gcgccaacac cgtctacatg
     5221 gtggccgtct tcctcagcgg cgccatcgcg gcggccctgg ccagcgcctg ttacggctcc
     5281 tacggctgga gcggtgtctg cgccgtacag gccctgctcg ccctcggcgg gctgctcgcc
     5341 cttccggcca tgcgccgcta cgaccttcgc cacgcgggag ccaccgcctg acatccgtca
     5401 gcacttccgc ggcgtcccaa gaaagacaag agagaaagag aagaccgtga ccttcccggc
     5461 catgcccaag tccgtccacc agttcttcac cgcctcccag gcgggtgacg ccgacgcgtg
     5521 ggccgactcc ttcgccgaga ccgccacctt ccacgacccg gtcggtacgg accccctcga
     5581 aggacgcgaa gccatccgcg ccttcatcaa gtccgtcatc ccgaacttcg accccttcct
     5641 cggtctcacg ccgctcgagg cgcacaccgt aggaaacttt gtcgccgtct cctggcgcgg
     5701 tgccgcggtt tcactcgacg gcaagcccac caactggtcc ggaataaatg tctacgaaat
     5761 cgacgaaaac ggcctgatcg ccgaggccaa ggcatacttc aacagcgcgg tgttcgcggc
     5821 tcagctctag atggtcacga gggtgggaac gcggcgacct cgctgttccc accctcgacg
     5881 gccgcccacg acacacacat cgccacatag cattttcgat cttttttcgc actgataccg
     5941 atcagagagc tggattgtcg ggggaccagc gttgctcgcc tcgccacact tcctggaagg
     6001 ctgaagacac atgatcgaaa ccattatcga aaaaaccaca ccgttatcac tcacatcgca
     6061 cggcgtacag gtcaaacttc tcggtgtccc ggaaatcctg gtggacgacc aaccggtccc
     6121 gctgcggggc gaaacggcac ggagggtcct gtgccacctc cttctcgcct caccccgcgc
     6181 gatccccaac cagcggctca tagagtcggt ttggggcggt gaagaacctg acagcgccat
     6241 ggagcagatc cggaagatcg tgtcgaagtt acggcgggat ctgcccgggg ggcgcgatct
     6301 catcaccacg gaactcggcg gctatcgcat cacgttggca ccggagcagc tggatctcac
     6361 cgtgtggacg aatgcgatcc aggacgtcca tcaactcatc gaagcgggcg accatcacgc
     6421 cgctttcgag aaactgtctc tcgcgctcga cctctggcgc ggaccggctc tcgacggcct
     6481 cgacggccag cctttcgcga atgaggccgt cgcgctgcac gaggagcgcc tcaacgcatt
     6541 ggaaacgtgg tgccgcctcg ccatgaatga gctgcccatt tctacggtca tcgcgaagat
     6601 ccgcagagag atctcccaac accctttgca ggaacggctg tgggacacgt tgatgcgact
     6661 gctggccgac aacggccgcc cgctcgaagc cctcaacgaa tacagcaact tacgcaaggt
     6721 tttggcccag tccctgggcg tatcgccgtc accacggctt caggacacct atcgcagact
     6781 ggagctcatg gcgaacgggg agacggcccg gccgaacctc cgccagacga ccgagcgcac
     6841 ggccgcgccc ccacacactc cgaagatacc cgtgtggatc aaagaacttc tgcggggtca
     6901 ggaaccgaac cccgcttatg tgtcggacaa gtactggaac atcgtgcacc gcaatcaggc
     6961 gatggcgcgc tggttcccgt ggcttcaggg ccccgacgcc aatctcatga catgggccct
     7021 caccaacccg tccgcgagac gggtactggg tgactgggaa gatcacgccg cggtctatct
     7081 cggaatgatc gaccgcgcgt tgcgccagaa ccccgacgac gccgccctgc gttccctcag
     7141 tgcaacgttg tcggaggccg actcgctccc cacgacggtc cgggaccagc cggtggacgt
     7201 cgcgacgcgc gagggccacc actacaccct caacctcccg cacatcacgc ccgagccggt
     7261 caacgtggtg tcccacatcc tgacccccca cgggcacggc gaactccgcg tcgtgctcct
     7321 cacctcgccg caggaaccgg ccgcctgatc cggcgccccg ggccgccgtc ccccgcggct
     7381 gcccggggcg ccacttccct gccccctgcg ggcccacccc ctcgctcagg cgcgggtcac
     7441 gcgggacggc ccagaggggc ggagtgcggt caggcccgcg ccggctggtt cagcacatgc
     7501 cggccgactt cccgcgagac gatcttgaag caggagtgct cgtcgagggc ggtgtccacg
     7561 agcacaccgt cgaacttgct gcggacgatc tcgaaggcgt cgatccgcgc gttgaagagc
     7621 agcgggtcga catagtcgtc gcgctccgcc tcgcgcgcgt tgatccgctt gcgggcctcg
     7681 atgaagctca cccgggtgaa gaacgccacg tgcggcgtgg ggaactcgga gatgatgtcc
     7741 gagacgaccc gccactgcgt gggggtgagc ccgctggagg agatgacggc ctcgcacagc
     7801 gccgagtaca gatagcggtc gacgatcacc gcgtatcccg cgtcgagcag cgggaggatc
     7861 ttggtcctga tggtgttgag ccggtccccg gtcaccgcca ggaacatgga gaagatgtcg
     7921 acccggccct cgggctccgc cgtcagcgga tccttcttgt actccgtgaa gaggcggagc
     7981 tttttgcact cgttgctggg cagtttgaag acgcggaccc gatagccgtt cctgcgcagc
     8041 gtccccttga ggcgcctgat gctcgtggtc ttcccggacc cgtcgacgcc ggagaagctg
     8101 acgagtacgc cccgctcggg cttggggccg gtcgcgaggg ggacgggtat gtcgatcact
     8161 tggcgctccg ggtgatgagt tccgtgatga attgcatgtt gcgctgcggg ttgaagagca
     8221 gcccctcgga cgcgttgggg cgattggcct tgaacgaggg gcccatgcgc cgaatcacgt
     8281 cgatgagtct caggaaccgc gcgtcgcgga gcagttcgtc gtggagttcg gggcggaaga
     8341 aggagtagta cgtgaagtcg ttcgcgtaga gcggcgcatt gcccccgtac acctcgggcg
     8401 tgatcttgaa cggcacgccg cgcagcgggt ttccgggcca gatcgtcccc ggctcccggt
     8461 cgtacgcggc gtccgtgatg tggcccccgg tcagcacccg ggcgatgttc gacttgcgga
     8521 acatctcggg gtcgcggccg cggtcgggca gggcggcgat cagcccgtcc acgcccggcg
     8581 ccgtcctgat cccgttgacg ctgtgcgcga tgaccgaggt ctggtggtcg ctggtgaaca
     8641 ctccgtcgag gtgcggcggg aggttgaacc tggcgtactt gacctcggag agcgactgca
     8701 ccatggagat gccggcctga tgccccgcga cgaaaggacc gtggatgttc aggccgttgt
     8761 aggtgaaagc cgagttgatc ataaagggga aggagagggg cgggcccgat tcccggatcg
     8821 gatccagccg cacatcgatc gacgcgtacc ggagatcgac ctccttcggg tcgaatccgg
     8881 cctcctcgat cttgctgaac gcccagtcga agaactccgg cttcacatag tcgcgttcga
     8941 tcagacgggg aagtccggtc ggaggctcct ggtagaggta atcgctcagg ctgagattcc
     9001 gcaggtattc ctcccgaaga tcctggtcca aatagcgcac gttgacatca atgactgcct
     9061 tgggcacgac tacctcctct tcgggtggaa tgcaacgtct cgtacgggtt atgcggtcca
     9121 gtcgagaccg aggtccacgg cgcgcgccga gtgggtcagc gcaccgatgc tcacgatgtc
     9181 gacgccgagc gcggagatgg ccttgatccg ctcccgcgag acggagcccg agacctcgat
     9241 gacggcccgc ccgtcggtga actccacggc ggtggcgatc tgttcgtcgg tgaagttgtc
     9301 gaggatcacg atgtcgaccc cgacctcgat cgcctcgcgc agctgctcca gggtgtcgac
     9361 ctcgcacgtg atgcgggtcg cgtgggtggc gaccgcccgg gaacgggtca ccgcggcggt
     9421 gatgcctccg gcagccgcta cgtggttgtc cttgatcagc accgctgcgc cgaggtcgga
     9481 ccggtggctg tgcccgccgc cgcaccggac cgcgtagcgc tccacgatcc gcagtcccgg
     9541 agtggtcttg cgggtgtcgg tgatccgggt gccggagccg ggggtcaggg cgtcgacgaa
     9601 cgagcgggtc agggtggcca ccccgctcat ccgctggacg aagttgaggg ccaggcgctc
     9661 gcccttcagg agcgactggg cggggcccgt cagaaggacg gcggccttgc cggccgtgag
     9721 ccgttcgcct tcccggcaca actgctcgac ctggacgcgg gggtcgagct gggcgaagac
     9781 ctcccgcacc agggccccgc cgcagaagac gaggtcctcc cgggccgcca tgagcgcccg
     9841 gccttcggcc tcgggcgaga cgcacgcgtc cgtggtcgtg tcgccccggc cgaggtcctc
     9901 gatcagacag cgggagacca gctcacggat gacgggcagt tcgagcatgt tctttccatt
     9961 tctcatggtg aaggagcggg agttttccgg gagttgggcc tcaggtcccc agcaacagga
    10021 cgtcgggcac cgcgcggtcg ggcagcgcga tgcggagcag gccgtagccg atccccgccg
    10081 cgccgttcat caggcccggc acccagagac ggcgcggaac gcccgtgcgt acatcgcccg
    10141 cgaggacacg gtgtgccacc ccggtcgccg cccggcgggc ctcttcgacc agggcccggt
    10201 cgccggagcg ttcaccggcg gtgagcaggg cgtgcgcgag accgagggtg ccgtggcaca
    10261 gcgagtcgtt gccgaccccg gcccgcaggc cctcccgtac ggcggagagc tccggccggc
    10321 cggcgaaccc acgcatcctc gcggtggcca gcagagtgcc ggcggaaccc cggcaccagg
    10381 cgttgacgcc cggaccggta cgggccgccg cacggtcgtt ctcggccagg gcgcgcgagg
    10441 cggcctcggc gtagcgcggc tcccccgtca gctccccgat cgcggacaac gcgtaggccc
    10501 ggcccgcctg tccgtgcccg aatccgtgga cgccttggcg cgtcggagcg tggtccagga
    10561 ggatctcgcc cgcccggcgc acggctgcgc gcgtcgactc ctcgggccgg gtcgcgtgga
    10621 gggagatcaa cgcgagcgcg gttccggccg cgccgcccac gatgtcgaag ctctcgtcgt
    10681 cgtcgaggtt ctgccgtacg gcgggcacca gggagcgggc cgcgtcgagg agtgcggggt
    10741 cctcccacag ccgtccgacc cggtcgagga ggagcatgac gccgcacagg tcctcgtatc
    10801 cgccgacggg cagggcgcgg aggtcttccg gttcgggcat gccgtcgggg tccgcaaggg
    10861 ccgccacgac gtcgcgcgcc tgccgctcgt agcggtcgat gccggtggcg gcggcgagtt
    10921 ccgcgaggaa cagggcgatg ccggtgacgc ccgagtagag cccgagcccg ctgggcccca
    10981 ccacccagta ccggtcgccg accaggttga ggttggccca ctccacgacg ccgtccccgc
    11041 cgtgccggac ggaggcgagc agctggtccc cgatgcggga agccgcggcg agcgccgtat
    11101 cggggtccac gtcctgccgg aggtgcgggc cgacctctac gcgggcctcc cgggcggacc
    11161 cgccgttttg cgcgggcccc tgctcctgcg cgagcccgtt ctcctgggcg gggccctcct
    11221 cctgcgcgag tccgccctcg tgcgcgagcc cctcctcctg tgcgtgtccg ccgagttcgc
    11281 gggtggcgag ggaggcgtgt acgaaccaga gctggtcccg cagatgttcc tcgctcaggg
    11341 acgccagccg acgccgcgcg gtatccagtc cgctctgccg gaagaagccc ttcgcgagcg
    11401 tgacgccctc gtcgtcgaag agcgccgtgc cggagggctt ggcggtgaag acgggaacgt
    11461 caccgcgggc cagctgcccg agttcgctcg ccaggaccac cgcgtcgccc tgcgcgtcag
    11521 ggtccagcgc ctccagaagg taagcgcggt cgagaccgtc ccccagcagg tccgggtgcc
    11581 aggcctcctc cagtaccgct cggtaggtgg aggtgttgcg caggacggtg cgtacgtcgt
    11641 cgtcggcgaa ggcctccagc tcgcggagca ggtcctcgcg tccggcgaac agcagccggt
    11701 agcactcttc gaagccctcg atcagcccgg ggagcatcgc cgacgggtcg gcgggccggc
    11761 cgtccaggac gggacggttg cccgactccg ggacggggcg ccgtctccgt acgatccgca
    11821 tccggtcggt gccgccctcg gccaggacga tgtcgggccg gatctcgtac tcgccggggg
    11881 cggcgccacc cgccatggcg ctgatctcca tggcgtacac accgcttccg tcccccttca
    11941 ccacgcgctg cgggagcagc cccacggcga ggaccgaggc gcgcagcagc aggtccacgg
    12001 ggtcggcgtc ggcgtcggac gtggtcgcgg actcggtgtg gaacatcgct tccaggtcga
    12061 tgaacgcggg gtgctcgccc gccgcgatca ggttctccag gtgcatgtcg tagcagccca
    12121 ggacgtggaa gagcgctagg tgggcgccta gccgccaggc gaacctgcga aaagcgtccg
    12181 cgtgggcgca gggcgcggcg gtgacgaagg cggaccagcc gtagtccggg cgttccagca
    12241 ggtcgttggt gcccaacggg tggcgggcgc ctcggtcgtt gatccagcgc aggagccggt
    12301 tgacatgggt gtccaccgcc aggctgcgcg gcttgtagac caggcgggat ccgtcgcgga
    12361 aggccacgag cgttaccgtg cgcccgccgc ggtgggcgtc gccggcgccg aacgtgaggc
    12421 ccgccaggtc cttcaggccc tcgccggaca ccgcgaagcg ctcgcgcagc tcggggaggt
    12481 cggcgctcag tcgctcggcg aactccgcac ggacgtcggt ccaccgccgt acgtggccga
    12541 ccaggccgcg ggccagcacg gggtgcccgg ccaggaggtc cagggcccgt tcggggtccc
    12601 gcaggctctc gccgaacgcc tcgtagcggg cttcgggact cgcgccgtcg agccggccct
    12661 ccagccgggc ggcgttgatt tcgagcacca gcgtccgccg gaccatggtg cgcaaggtgt
    12721 cggtgtcggg ggtgaacagc gggtggctgt ccgggagttg accggccgcg ccgaggcggc
    12781 cgcgcagttc ctcccgcgcc cacgccgcca acgggcccag ccagtccagc ggtacgtcga
    12841 cgtcctccgc gtcggccgcg agcgcgggca gggccgagcc ggcgaaccgc tgccaggcat
    12901 cgacgaggac ggggacccag tccggcgcgc cggggagccg ccgcttcagc tcctgcggcg
    12961 tctccgcggc cagcagggcg agtcggtcag gggccaggcc ccaccgggcg gccagtacgt
    13021 cctgctctac gcgcagcccg gggacgagca gtccttcctg ccacaggcgg acgcgggccg
    13081 ttccacgctc gcgctcctcg gggtcgggtt cgaagccccc ggccgtgcgg cgctcagtgg
    13141 gggtgagccc cgcccaccag cgcgcgtcgt cgaggaatgc gtccagcacc gtctcgcctc
    13201 tcgttctctt cccgctatgc acggtccagg ccgggtacct cgatgtcgcc cgccggatgc
    13261 ggaggcagtg cggctcgcgc acggtcgtcc agggctgccc ggaacagcgg gtcccgccag
    13321 gccctgatca cgtcggcggc cgtcggttca gacacggacg gcgccgtact cgaccagttc
    13381 ggacaggact tcgatggtgt cctcgacggc ggtctcgacg tcgatctcgt attcccgggc
    13441 gaggagttca ccgatgccgc ccacggtgag gaccccgtcg atccgcttcc agatgaacgc
    13501 cgtcgtctcc gccagctcga aggcctgctc ggggaccgcg accaccaggg tgccgcggat
    13561 cttgcgcacc cggatgtcgg ggcggacgga cgggatggac tcggccgtga ccggacccgc
    13621 tgtgctcatc agatgtccac ttccatggcg atgccgcggc agaccgagag cacctcgttg
    13681 atccaggccg cgggctgtgc ggggtccagc gaccgcatcg tctccagagc ccagtacgtg
    13741 tcgtacggca gcacggcggg ggcggcggcc cgcagccttc gggcccgcca cttctcgccc
    13801 ggcccgcact cgccttccga ggcgaggagc gcgtcgaccg tgtagtggaa cgcggcccgc
    13861 gcggacagca cggcgctgtc cacgtctccg gcctccagct ggcccaccgc gtcctcgacg
    13921 cgggagtcgg ccatgttcag aatgcgagcc gcgtggatgg agcggaacgc ggattcctcc
    13981 gcttggacgc gccagtgcga cagcagctcc tgtccgcccg ccgccgcgcc gaaggcgagc
    14041 cggtccagca actgcacctc gcgcagggcg agttcctcgg cgccctgctc gaaggcctgc
    14101 caggtgacct tggcgaggac ctgctccacc tggccgcgcg tccagtaccg gatgtcccag
    14161 cgcatcgcgt cgacgaaggt ctcctccccc agtacgacgg agggtacgag cggtacggga
    14221 tggcgcgagg cgcccttgcc cgtccacggc tcctcggaga tcacgtagag atccacgtca
    14281 ctggaggcgt tgccccagcc ccggaccagg gaacccgcct cgaagacaca gacccaggac
    14341 tcgggcagca ggtccagcgc gcgcagttgt tccagctggt gcgggcggtc ctcagacacg
    14401 gtcggctccc ttcggggcgg cctcgacgac gagtccgagg tcgagcacct cctcgagcag
    14461 cggcttcagt tcggcgagcg tgtggccgtt gcctgccagt accttctcca gcgaggtctc
    14521 gccgtcaagc gagcgcagca gcgcggtcag gccgggctcc tcgtcctcgc tgaggacgaa
    14581 ctcgcacgcc ccgtcgacca gcaggtacca gatgccgggc tgggccggca cgcaggcgag
    14641 cagggtgtcg tcccgcagcg cgtacacggc ggccgggtcc accgggggcc gcggcatggt
    14701 gagggcgcgg atctgcccct cgctctcgtc ccagtcgccg tactcgaagg tcacgggttc
    14761 gggggtggcg gcgctgaacg cggctgacgg aggggcggga aggtccgcgg tcatgcgttc
    14821 cagcaggccg aggttgacca gccgcagcag gtgttcgacg ctgccgttct cggggtcgcg
    14881 ctccaggcgc cgcaggctct cgcggacgcc gtcctggtgg atgaactggc gggcccgctc
    14941 ggaggagaag gcctcttcga ggagcgcgtc gccgccctgc gccagcatgc gggtgaaggt
    15001 gcggtaggtg tggcgctgcc cctcgccgtg gaagaagggg accttggggc ggttgatcag
    15061 ctcctcgggg aggatgccga ccatcgcccg gcgcaggatc cgcttgtccc agaggaggtt
    15121 ctcgcggcgg gcggcgggga tcgacgcgac cagctcgacc agacggtggt cgaggaaggg
    15181 cacccgggcc tcgacgctgt tgccggcggc cgtacggtcc tcgtgccaga cgttgtactg
    15241 ctggaggctg cggtacttcc aggcgatgaa cgcgtcgtag ggatccgggg cgtcgacgcc
    15301 caggccggcg tgtgcggcct cgtccttcag cagcggcagg tcggacatct gccaccaact
    15361 cgccagctgc ggccggctgt ccagggcctt gcggcgggcg agggcgccga tgttggtgat
    15421 gaagtcgctc caattgccgc cctcgccggt gtagttgagg gaatagcctc cgttgaactc
    15481 gtcggaggcg gcgcccagca gcatgccctt gatctcgggg tggcgcaggc gcgcgtggcg
    15541 gtgcagttcg tacttgtaga actgctccgg gctgcacagg ggcgtctcgg tgagccagag
    15601 caggttcttc cactcctcga tccccgggac ccggtcgccg tcgaagagga tctgctcgtt
    15661 cggcacgccg agcatgtggg ccgcgcggtg gctccactcg gcgtcgccgt tgaggacggt
    15721 cgcccccgtg agcacgctga aggtccgcag gccgctctgg ccggccagcg cggccaccgc
    15781 ggaggagtcg attccgccgc tgaggaacag tccgagttcg gcgtcggcca tggcgcagtc
    15841 ctgtacggac gcggcgagga gatcccggta gcgctcgatg tactcctcgt ccgaggcgtc
    15901 ggagtccgcg gccgcgccgg gcagcgacca gtagcggtgc tcgcgggtgg cgccgtcctt
    15961 gaggtcgatc tccatcaccg tggcggccgg ggccagttcg atgccctcga accaggtgtt
    16021 gaccggctcg tggatgaagg cgggcgtcga gctcatgccg tagtcggcga gcgcgccgct
    16081 ccagtccagg cgcctcgggg tggcggggtc ggtgaagagc gccttgatct cggaggcgaa
    16141 gacgatccgc tcccggtcgc ggtggtagaa gagcggcttg atgccgaacc ggtcccggca
    16201 gaagaggagt ttgttctgct tgcggtccca gaggaccacg gcgaacatgc cgttcacgcg
    16261 gtcgaggaag ttcaggccgt cgcgctggta gaggtgcagc agcacctcgc agtccgaccg
    16321 ggtcttgaag cgggcgcccg gaggcagcga cgcggccagc tcgcggtggt tgtagacctc
    16381 gccgttggcg atcaggacga cggaaccgtc ctcgctgacc agcggttgac cgccgccctc
    16441 ggggtccacc agggacagcc gggtgaaggc gaggcccacc tggtcctcac gcagcagccg
    16501 ttggtcgtcc gggccgcggt gggcgagcgt gcacgccaag tcgcgcagca gctcgtcggc
    16561 ggcaggtgtc aacatgccac cgtcgatccg ggcaacacca gcgattccgc acatgtcatt
    16621 cactttcgtt gcgacccgag tgggaactca gcgataaaac gggcacgcgt cacgcccaac
    16681 cgggcgtgac gcgtactcgg cgagctattt agcgggtggt cacgatgacc gtaccgaagt
    16741 cgaccttctt ggtcgacggc ttgatgtact tcttcatgtg taatcacctc catccttgaa
    16801 tggaatagag ggagacaggc cgcaggccta agcggtcgtc gcggagcggc acaaaggaag
    16861 tgaattatcc aaccggaatg cgcccccctt ggtcgccccg ttcggaaacc gagacggtca
    16921 ccttcgccgg ccctgtgccg acttgccccc aaaccagatc tgtccacgtc gcagacgggt
    16981 tctgaccggc gacagcattg tgcgtcctgg cgtgatcttc cgtcaacccc cgtttgccgg
    17041 aaccctgttg acctgtggaa cagggcgatt cccgcagacg gatttcttaa ttccgcttaa
    17101 ttctactacc cgttaccggc ggttccctat tggcctgaca gagcgtcacg gggaaggccg
    17161 cggtggggcc gctcgccaga atcggatata tcggaaattc aacgaagcgg gttgctgtgt
    17221 cgcgcaccca aggatgcccc gtcgacgaga aatccattcg cctcgccgtg gaggggtggt
    17281 gatacagtcg cggccatgaa tctgcgtaag ttccaggcct tcagcgggcc attgagcgac
    17341 agcaggttcc gcgttctctg gttcggacaa acgctttcct atgccggcag tgccattttc
    17401 cccgtcgcac tcaccctcgc gttggtgcag ggagtcggat cggccaccga cctgggcctg
    17461 gtcctggcca gcgccgcggt cggcgaagcg ctcttcctcc tcgtgggcgg ggtctgggcc
    17521 gaccggctgc cccggcagaa ggtgatgatc gcggcggact cgatccgctg tgtcgcccac
    17581 gtcttcatcg ggctccgcat cgtcagcggc caggccggtc tcgccgaact gatgctcgcc
    17641 tccgcctgcg tgggcgcggc cacgggcttc ttcctgcccg cctccagcgg tcttgtcccg
    17701 tcgacggtca ccccggagct cctgcaacgg gccaacgcgg tcatggccgt ctcccggcgc
    17761 tcggcgatga tgctggggcc cgcggcggcc accaccatcg ccctcaccat cggccccggt
    17821 tgggccatgg tcatcgacgg cgcgaccttc gcggtcaacg ccctgatgct cagcagactg
    17881 cgcgtcgggc acgtggcggc gccgcgcgag agcttcctca aggagctccg cgagggatgg
    17941 ggcgagatcc gtgaacggac ctggctgtgg agcaactacg ctgcccacgg ctgctggaac
    18001 ctgtcgcgga ccgtctactt caccgtcgga gcggcgacgg tcatcagcgg cctgggcggc
    18061 gaggtggcct ggggcatcat cgcccagggc gcgacggtcg gggccctcac cggcgcgctg
    18121 gtctccctac gagtccgcac gtcccggccc ctcgtcgtga tcaacatctg cctctcgctc
    18181 ggcgccatac cgctcgccct catcgcgctg ggggccccga ccgcgctcat cgccgtggga
    18241 gcgggcgtca tggccttcgc gctcggcctg atggggacgc tgtgggacac cgcggtgcag
    18301 cagcagatcc ccaccgaccg gatgtcccgc gtctccgcct acgaatggct gctgtccagc
    18361 gcgctcatcc ccctcggcat ggcgctggcc ggccccttgg ccgggctcgt cggagccaag
    18421 gcggcgctct acggcgccgc cgcgctgatg gccgtatcca gtctgggggt gctggccatc
    18481 cccgaggtga ggcgcctggg gcgggcccac ggaccggtcg tcgccgaaga ggccgatccg
    18541 atcagcgccg gcgcctaggc ccggagacgg agatggagaa gaccacgcac cgcgcgcccc
    18601 tgcgccagac cctcacccgg ctgaccgacc ccgaatcgcc ggtggcggcc cagtaccgca
    18661 gcaggttcgc cctctgggac gcgcgcgcca gcgtgcgcgt gaagccgccg cgcctgctga
    18721 cgcccgccga gcccggccgg ctctacttcc cgcccgagct gatgccggtc gtcgcgcatc
    18781 cgctcgtacg gtcccggccg tacgaggtga cggagcgcgt actcacccaa cggctgcacc
    18841 agtacctgta cttcaccacc gagctggaac aagtcgccgt gatgccggtg accatggaca
    18901 tcagccgggg ccgcagcggg ctcgacctgc cggccgccat gcgggaggac gctttcaaga
    18961 tcacgacgga tgaggcctgg catgcccagt tctccgacga cctgtcccgc caggtccagg
    19021 cgcggaccgg cttcgacgcc tgcctgccgg accgcccggc gttcatcgac cgcctcgacc
    19081 gcatccgggc ggggatggac cacgatctgc gcggagcggc cgacctcgcc ttctccgtcg
    19141 tgagcgagac cctgatctcc tccatcctct ccgacctccc ccgggacaag cggctgccgg
    19201 aagcggtcag ggagctggtc caggaccacg ccgaggacga ggggaaacac cacgcctact
    19261 tccgcagcct cctcgaattc ttctggcacg cactcgacgc accggcgcgc agacggatgg
    19321 gcgcactggt cccggagctc atcaccgcgt tcctggaacc ggactacctg gccatagccc
    19381 tcacccttgg ggacgccgga ttcagcgcgg aggaggccga ggagatcctc accgactctc
    19441 atccggccga cgcgacccgg gccgccatcg gccgggccgc ccaggcgacc acgcgctact
    19501 tcacggaagt cggagcactg gacaccccat ccacacacga ggccttcgcc tcggcgggcc
    19561 tcctgaccac gaactgaccc acctcccggg cgagaccggc gggcccggcc gacgcacgac
    19621 gcccccgagg cgctcgtcgg ggcgggcgtc gggggcgtgg gggacgtcgg cgggtggggg
    19681 gacgtcgggg gggccggcag atcaggcgtc ctcgcgcggc agcaggtgca ccaggcggcc
    19741 ggaccactgg tgccacaccc agaccccgta ccagcgcacc tcacgtccgg tcagctgctg
    19801 ggcggccgcg tgcgcgacgc cgcccggcga accgcgcggg cccggctgcc ggcaggtgac
    19861 tagctctccc ctgctacccg taacgggtgc cgcaggggcg ggtcgtccca gaaggcggcg
    19921 tggtcagcgc cggccgccca tgcggcggtc gtcggccagg gcggtcagcg ggccgaactc
    19981 gcgggcaagc tgggtccacg tcagaacctc gccacagcgg gccgggaatt ccttcgggtt
    20041 gaactcgggc atggtccagg tgccagtgcc ccggtcccgc agccacaggt ccccgtcacc
    20101 gtcgaccacg gtcggcggga ccggtacggg ctcggcctgg tcgacgggct cccaggtgat
    20161 ccggcccggg tgggaggcgc ggcgcagctc ggtggtggcc agccgcgcgg ccaagtcacg
    20221 ggtggactct tcggcgccct tgaccgactc gagccggtat gcgtcgtcaa ggacgggcag
    20281 ggctggattc ttgctgcgct ttgaactcat acgctggcta cctccggtgg ggggcgccac
    20341 atccgttatg gcaccccgta gaggaacacg gtatccgagg cgggagctgg gtcggctacg
    20401 gccactgtcc gccgcttcgg acagggtcgt cgtggacgtc ggggcgtgcg tcagcggacc
    20461 tggagaccca gcgcgagcgt cagctcaagg acgcattgcg gcgatgcgag atccggaaac
    20521 agttctcgca gctgtgacat ccggtaccgg acggtctggg gatggacgaa caatgccttt
    20581 gccacttcgt cccgcctgcc ctggtgcagc agccacgccc gcaacgtctc ctccagtcgc
    20641 cgcgcggtcg cggcgggcac ggtccgcagg ggtgcgaggg ctcgggcacg caggtccgcg
    20701 aacgcgtccg cgtcggcgct cagtaccagc tcgggcaggt ggtcctcggt gtcgcggatg
    20761 tcggcggaaa gggagcgcgc gcgtacggct cgtgcgtacg aggcggacgc acgagtccat
    20821 ggccgggccg ggccgaccac ggcggcgcgg tggttcagct gtctcaggag atgggcccgg
    20881 tcggcatcgg ggaccagcag cacgcccaag gcgtccggca gatcgtcgag gacgagagtg
    20941 ctggggtgga gcgtgcggta ggcaggccgg gcctgggcgg cgggcagcag caccgcggtc
    21001 agcgacactg gaggctgcca cccggcccgt tgcacggagg ctcgcagcac gtccgggctc
    21061 gcgtcggcga ggaggtcgcg ggccaggtgt tccaggtgac gctcctgagc ccggccctgg
    21121 gcggccagtt cgtcggcgtg gccagcggcg ctcgcggcgg agagctcgtc gatgtaggcg
    21181 aaggtcagct cggcgaactt ggcgacttcg gcggcgggca gccctgcggg cacggcaccc
    21241 gtggccaggc atcgccaggc cacgcgggct ccgacgcggt aggcgctgag cagggcgtcc
    21301 atcgaacggc cctcgcggac ctcgccgcga cccagctcgt aggccgcgtc accggcatcg
    21361 ccgcctgtgg cgttgccgct cgcgaggtcc agatggtgcc ccagggcggt gcgtacggcg
    21421 cggcggatga tgccgcccat gcggcccgaa agggcgttgg cgtagggagg aacctcgtcg
    21481 atgatcgcct ggacgatctc gtcggcggtg ttcttcagcg cggcccgcaa tgcgctgacc
    21541 gtcgtctcgt ccagggtcag ttcgctggct ctcctgatgg catggttcat gttttgtttc
    21601 ctgcgaacaa ttcggccgac cagattcacg ttctggggac aggactttac gccctgaggc
    21661 gcatcaaggt ggagtcatga ggagtgcggc cctccgcggc agggcgtgga aactgctgga
    21721 gacggtcacg acgccgctgt tgccgtcgga ctacctcgac ctggtcagtc cgctgcgtgc
    21781 gggcgctgaa ctgcgcgggc gcatcgaggc agtgcacccc gagacgggtg acgccgcgac
    21841 cctcgtgatc agaccggggc gggggtggcg cggccacacg gccggtcagt acgtgcgcat
    21901 cggggtcgac gtcgagggcg tacgcctgtg gcgtgcctac tcgctcacct caccgacgga
    21961 ccgccgggac ggccgcgtca cgatcaccgt gaaggcgatc ccgggcggca aggtcagcaa
    22021 ccacctggtc cgcagggcgc aaccgggcac gctgatccgg ctcgaccagg cgaccggtga
    22081 attcgtgctg cccaagccca aacccgccaa ggtgctctat ctgacggccg gcagcggcat
    22141 cacgccggtg atgggcatgc tgcgcgacac cgagttcgac gacgtcgtca tggtgcactc
    22201 cgcaccgcgg ccacaagacg tgatcttccg caacgatctg cacgacctgg tcgcggagaa
    22261 gaagctgcgc ctcaccgagc tgcacaccgc cacggacggc atgctcgaca tcgcccgcct
    22321 cgacgagctc gtgcccgact gggccgagcg ggagacctgg gcttgcggac ccgcgggcct
    22381 gctcgacgcc gccgaggcgc actggaccga gcagggcgtc caagagcgcc tgcacaccga
    22441 acgcttccgc cccagcgtcg tcgtctccgg ggacggcggc gaggtcacgt tccgcaccac
    22501 cggcaagatc gtcgacgcgg acggcgccac gccgttgctg gacgtgggcg aggaggccgg
    22561 cgtgctcatg ccgtccgggt gccgcatggg catctgctac ggctgcgtca caccgctcaa
    22621 ggcgggggcc gtccgcgacc tgcgcaccgg cgagatcacc gaggcagagc cgggcgtcct
    22681 catccagacc tgcgtgtccg ccgcggcggg cccctgcgac atcgaacggt aggagaacct
    22741 tgaccgccat tgaccccacc gcccacctga gcggggagca gatcgaagag cttggccgag
    22801 agctggacgc gatccgcgac ggggtgatcg ccgcccgcgg cgaaaaggac gccgcctaca
    22861 tccgaaaggt catctccgcc cagcgggggc tcgaactggc cagcaggggc gtgctgctgt
    22921 tctcggcctt cccgcccgca tggctgatcg gcaccgccgg tctgtccgtg gcgaagatcc
    22981 tggagaacat ggagatcggc cacaacgtcc tgcacggcca gtgggactgg atgcgggacc
    23041 cgaagatcca ctccactacc tgggactggg atcacgtctc gccggccgag cagtggaagc
    23101 actcgcacaa cgagctgcac cacacgtaca ccaacgtgat cggcaaggac aacgacctcg
    23161 gttacggcat catgcgcgtc gacgaggacc agaagtggca cccgctccac ctcggccagc
    23221 cgctgtggaa cttcctcaac gcctgcttct tcgagtacgg catcgccgcc tacgacctgg
    23281 agctcggcaa caacctggac aagcaccgcc gcaaggaccc ggagttccgt gcgcgggcca
    23341 aagccgtcgg ccgtaagatc cgcaagcagg tgctcaagga ctacgttgtc caccccctgc
    23401 tgtcgggccc gtcgttcctc agcacgctcg ccgccacgtt taccgcgaac ctggtccgca
    23461 acctctggtc acactcggtg atcatgtgcg ggcacttccc cgagggcgtg caggtcttcg
    23521 aacgccggtc gatcgagcgc gagacgcgcg gccagtggta cctgcgccag atgatgggtt
    23581 cggcgaacat cagcggcagc aaggccatgc acttcatgac cggcaacct
//
