LOCUS       NZ_CP032698            20579 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1975540
            Orig. end                         :: 1996119
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20579
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="13"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20579
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20579
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10579](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10579)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     gene            complement(136..1236)
                     /locus_tag="DWB77_RS08800"
                     /old_locus_tag="DWB77_01767"
     CDS             complement(136..1236)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007492352.1"
                     /locus_tag="DWB77_RS08800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01767"
                     /product="ionic transporter y4hA"
                     /protein_id="WP_246033468.1"
                     /transl_table=11
                     /translation="MIRLARLPLDRWSAVMPPLAVVLLALTWGRSLPGVLVALVACFLA
                     GAVLAAVHHAEVVAHRVGEPFGSLVLAVAVTIIEVALIVTLMSDGGDKSASLARDTVFA
                     AVMITCNGIVGVCLLVGAVRRRLAVFNAEGTVTAFATVTTLAGLSLALPTFTTSKPGPE
                     FSPAQLIFAAIASVFLYGLFVATQTVRHRDYFLPVTQQGEVMRDDAHANPPSARTAWTS
                     VILLGVALVAVVGLAKGVSPTIERGVAAAGLPASVVGVVIALLVLLPETIAAVRAARRD
                     RVQTSLNLALGSAMASIGLTIPAVALATIWLSGPLVLGLGASHMVLLALTVAVGILTVV
                     PGRATLMQGGVHLSLFAAYIVLAVSP"
     gene            complement(1292..2662)
                     /locus_tag="DWB77_RS08805"
                     /old_locus_tag="DWB77_01768"
     CDS             complement(1292..2662)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535678.1"
                     /locus_tag="DWB77_RS08805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01768"
                     /product="Ada metal-binding domain-containing protein"
                     /protein_id="WP_120720717.1"
                     /transl_table=11
                     /translation="MDHDAAYEAVTSRDARFDGEFFFAVATTGIYCRPSCPAVTPRRKN
                     VRFFPSAAAAQNHGFRACRRCRPDAVPGSAEWNARADVVGRAMRMIGDGVVDREGVPGL
                     ATRLGYSARQVQRQLTAEVGAGPVALARAQRAHAARVLLQTTSLPVTEIAFASGFASVR
                     QFNDTIRQIYARTPSGLREEAGTRATRAGVAAAAGIPLRLAHRGAYAVKETFDLLAAEA
                     VEHVEEVAGASGARTYRRTLGLPHGTAVVAVDEAAPAHTAARQGWLDARIHLTDLRDLT
                     TAVQRLRRLFDLDADPYAVDERLGADPRLAPLVARTPGLRSPGAADPEECAVRALIGQQ
                     RAAGLVETYGKRLDVPCGTLTHLFPDSATLAPHPDPHLAALATALADATLRLDAGADRD
                     EAARVLRTLPGMDEETVQVIRTRALGDPDVGPADRDAWRPWRSYARRHLAVAAAGRR"
     gene            complement(3230..4378)
                     /gene="rsgA"
                     /locus_tag="DWB77_RS08810"
                     /old_locus_tag="DWB77_01769"
     CDS             complement(3230..4378)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267262.1"
                     /locus_tag="DWB77_RS08810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01769"
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="WP_120720718.1"
                     /transl_table=11
                     /translation="MSSSFSTPFNTSAFGTSGFNTSAPSRPLAAYGWDDAWAAEFTPYA
                     EQGLVPGRVVRVDRGQCDVATADGTLRADTAYVTPHDPMRVICTGDWAVVEPGGDPRFV
                     RAYLPRRTAFVRSTSSNRSEAQILAANVDHAIIAVSLAVELDLGRIERFLALAWESGAQ
                     PLVVLTKADLVPDPVGLSYLVRDVETAAPGVQVLPVSATTREGIDILAAVVAGGTSVLL
                     GQSGAGKSTLANALLGAEVMVVQAIRDVDGKGRHTTTTRNLLVLPGGGVLIDTPGLRGV
                     GLYDAESGVGQVFAEIEELATDCRFHDCAHQAEPGCAVLAAIEDGSLSERRLDSYRKLL
                     RENQRIVAKTDARVRAELRREWRLRGAEGRANGVLKRGRGVS"
     gene            4662..5840
                     /locus_tag="DWB77_RS08815"
                     /old_locus_tag="DWB77_01770"
     CDS             4662..5840
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129603.1"
                     /locus_tag="DWB77_RS08815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01770"
                     /product="cytochrome P450"
                     /protein_id="WP_120720719.1"
                     /sec_met_domain="p450 (E-value: 3.3e-15, bitscore: 54.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDPTQDPRFHQDPYPAYAALRSRCPVQRLANGPDGRASYVVTGY
                     AEAREALADARLSKDTAAFFAGKGSSRRLHPAVARTMLASDPPRHTRLRKLVTKAFTTG
                     AVAELRPFIAHVTDELLDRWPVGQQADFVADLAVPLPVAVICELLGVPQDDRPDVRRWS
                     GELFAAGRPDVIDAASHALADYMTNLIAAKRLRPGERLLDRLIAARDGDDRLSEEELVS
                     LAVLLLVAGHETTTHFLGNAALALLRHPAALDRLRADPDGIRTLLDELLRYDSPVSTAT
                     FRFTTEAVTLGGTDIPAGVPVLVALGAANRDPRRFPSPDLLDRDRDAAGHLGFGHGIHR
                     CVGAPLALAEAEIALRAALVRFSRLRLAVAFERLQWRRTRLVRGLTSLPVLT"
     gene            complement(5860..7128)
                     /locus_tag="DWB77_RS08820"
                     /old_locus_tag="DWB77_01771"
     CDS             complement(5860..7128)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638998.1"
                     /locus_tag="DWB77_RS08820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01771"
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_246033469.1"
                     /transl_table=11
                     /translation="MNRVRIAVAAVFLLTLTTTLTVGAGRPARATDAARDPALQHIAPA
                     LQHIDPAVEHIAPGVDYQALTLTTGHGPSRVHVVTVDLRHAGVGAGLLHAGTVTGRAPV
                     SAMAEQQGAVAAINGDFFNMTEAEHPGVAATGSASGAAVLHGQPLKGAVPQGQRFGWKM
                     PAGASGEDVLGVGQDGRARTARLTLNGQLHPPQGSLALKGLNQYALPEGSIGVFNPDWG
                     SVSRARAACGTDHKRAAPCTRDTFEVTVRDGRVADTATTPGSGPVPAGSLVLLGREQGA
                     RALRSLTPGTPVSVDYRFDSTGVTPFDFALGAYPLLKDRAPLPGLDDVTAEPRTAAAIA
                     DDGHLLRLVATDGRESTATGLTVAELARFLASLRCDEGVFLDGGASTTLVTRDPATGRT
                     TVRNTLDHGQQRRVPNGIAIYHH"
     gene            complement(7239..9209)
                     /locus_tag="DWB77_RS08825"
                     /old_locus_tag="DWB77_01772"
     CDS             complement(7239..9209)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188021.1"
                     /locus_tag="DWB77_RS08825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01772"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_120720720.1"
                     /transl_table=11
                     /translation="MRRPRRDRTAPAPDEDAQRPSDSEQLLFGGPLRYDTGWSQHEEAY
                     LALNLRAVLRRLPRLLASGFRLAWRADPRAARGLVAANLGRGLTQAASLLAVNRVLAGL
                     MTGGTMEERLRGVLGALVAVGVCLSAGALLRAVSTYATGRLEPRVERMATEVYLERASR
                     VELAAIEDDQFHKLLDSARYGASSARRMMSIGNRVISAAISFVTAAGVLTVLHPVLLPL
                     LTVMTLPGSWSALTTARRRYLSFHAWTQHTRAGALIGQMLTDAGAAPEIRVHGVGPFLL
                     RHFRALAESAEAEQSRLARLEARTGLIAAGWIGVATAATYATLGALLLGGAMALSVAGT
                     AVIAIRTGSASLTTLALEVNALHEQALFVGDLERLCEEAERRTRAPGGVALPEAPRLIR
                     FEQVTFTYPGEGTPALDDVTLTLPTGRIVALVGSNGSGKTTLARLLAGLYAPQRGRILW
                     DDVDAALADRRQLTDRVAMVAQDFTRWAFTARVNVLIGRPEAPAHDEHVERALRHAGAE
                     DLVAGLPRGLDTLLARGFRGGHQLSGGQWQRLGFGRAAYRAAGRPGQILIVDEPTAALD
                     ARAELQIFDEIRSLAEDGSTVLLITHRLASVRHADLVHVLDEGRLVESGAPADLLAAGG
                     LYAELYHLQANQYAPEDETCR"
     gene            complement(9216..10007)
                     /locus_tag="DWB77_RS08830"
                     /old_locus_tag="DWB77_01773"
     CDS             complement(9216..10007)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS08830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01773"
                     /product="hypothetical protein"
                     /protein_id="WP_120720721.1"
                     /transl_table=11
                     /translation="MLNETETARAILAVCGVGLAVSAGRDLRQSHEFGAGGALAWAVVG
                     AYPHRCPPAVRALFVGDRYRAVLAVQCAAGLAAPAVAALSAPGSAVVACVLLTTLLLGL
                     HRSDYGTDGADQMAALAMLTAAVTLTVGGTVGRLFLAFLTGQLILSYLIAGVAKLVSPT
                     WRDGSCLAQILSTDSYGSPGIAAFLRARPWVGALMAWGVMVLEVTFWLALVVPGPPRWG
                     LLAAGAALHLGIAFTMGLTTFVFAFIGAYPALVFTAAALTG"
     gene            complement(10001..10579)
                     /locus_tag="DWB77_RS08835"
                     /old_locus_tag="DWB77_01774"
     CDS             complement(10001..10579)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS08835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01774"
                     /product="hypothetical protein"
                     /protein_id="WP_162952481.1"
                     /sec_met_domain="cypI (E-value: 8.4e-12, bitscore: 44.6,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPALVAVVLAGWLLLTVVAALPRIGTATQRHVPDWFAPLLPAWT
                     FFAPNPATKDKVLMYRDILANDTVGPLRLVLPEGGAGGRPGKALFDAASQLLRRAAAGW
                     DEEPDARIRDARLMISTPYLLLLNRAATAPHDATAVSFEFVIAHASRRDEEPEVVFVSA
                     VHRLKGAAGSGAVAHGGPGRRAVREGTPC"
     gene            complement(10592..11338)
                     /locus_tag="DWB77_RS08840"
                     /old_locus_tag="DWB77_01775"
     CDS             complement(10592..11338)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS08840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01775"
                     /product="hypothetical protein"
                     /protein_id="WP_120720723.1"
                     /transl_table=11
                     /translation="MMLASTTAAAVKSVQVVTVPTDAAGVADGGLLPPAGTVVIYVGDA
                     AAPEWHRLRAAALDGDWQAVRDTAVPQHPNPGAELTAASTPFDLVCAGHVVAHGLALPH
                     GVPFRTLTFPYTGGPIRDADFGIVEHTDGGTPAVRTTCLLMRRAPELTRLERQLLDDMD
                     PEERHVHMRRPQPCQTLTAMDALTDGIGRAAQEAVREKHARGGYARDESATALSQSEIT
                     EIAGESGEPAAAVADLLATRRRHFSY"
     gene            11573..11968
                     /locus_tag="DWB77_RS08845"
                     /old_locus_tag="DWB77_01776"
     CDS             11573..11968
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS08845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_01776"
                     /product="hypothetical protein"
                     /protein_id="WP_120720724.1"
                     /transl_table=11
                     /translation="MAESKRDIREPGSHEPNSPSRSAYLRLLALQRAGEPTAPAGVEEA
                     GQQPERLERQAIVDELRPPVRMWPDYPDFWVESPRGGGPWHERFGDKGPRRSGSVARRG
                     GQEPAPSRMSVSEAFLRLRLTLGAEPA"
     gene            11965..13176
                     /locus_tag="DWB77_RS08850"
                     /old_locus_tag="DWB77_01777"
     CDS             11965..13176
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="DWB77_RS08850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01777"
                     /product="radical SAM protein"
                     /protein_id="WP_120720725.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.6e-41, bitscore:
                     141.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.2e-12, bitscore: 45.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDASPQRGEVGAAGREPMPPYLQLVVKVSKFCNLRCRYCYEFP
                     SLGDRAAMTVEQVRNMIRHVGEWLADQPGRTADFVWHGGEPLLMPPDFYREVKRAQEEF
                     LEPASIPYGNSVQTNLYRLTDDDLALMRDVFDDVGVSVDLVGGQRVNVAGRQAQPRVLA
                     HMQRLMDEGLNFGCITVLSRSTAPHVAEIHRFFEDMNLGFRMLPIYRTGYPGQQAEHEL
                     SAQEIVEAFKTLTDRWLVSDSFINVEPIEGYAAQVVHALSGADNRRYYDKELSETILVI
                     DTDGSVYSNGDAYDPALCHGNIFTDSLSSTRRSASFAEALRQSRQRVTDTCTGCRFHGS
                     CSGFFAAESTPEQRWRDPATGLSVCGVVLPVQEYIEERLTALGLVDGVTRRLDRALLER
                     RALD"
     gene            complement(13264..14157)
                     /locus_tag="DWB77_RS38800"
                     /old_locus_tag="DWB77_01778"
     CDS             complement(13264..14157)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="DWB77_RS38800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01778"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_120720726.1"
                     /transl_table=11
                     /translation="MPDLRGSVTEAEEFRRQLLAAAARATTVAELATELSRLLHPFLPH
                     DGHTLAGLDPLTGVGCLHHDLRPSKGPGSELPIALTLRGRVWGGLVLLRGGDGTPFSEA
                     EARCAERLAGPLSAALRQYVAGKPLRPGRRGLFPGVIVIGPDDTIKGMTSTARTWLHEF
                     LPETPPAKDDELPHLLWGITYFTRRTHTTALSRIPTGGGWVAVHAQLLDGKEEGDIVIT
                     FQSAPASQLLPAIFVWYGFTPREQAIVECLLGGLATKRIARLLGMSPHTVSGHLRSVYR
                     KTGTGGREELIAGLRQ"
     gene            complement(14466..15671)
                     /locus_tag="DWB77_RS08865"
                     /old_locus_tag="DWB77_01779"
     CDS             complement(14466..15671)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037104.1"
                     /locus_tag="DWB77_RS08865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01779"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_120720727.1"
                     /transl_table=11
                     /translation="MQPANETPERTSGRLHRARVLYRNVSKRKLGWLLLKDTVNSCVEY
                     RILGLAAEAAFFTLLSLPPLLLSVIALLGYVDGWTSTHTVASIEQNILNAAGTVLSDRG
                     VHEFAQPLLDDVTQGKRPEIVSIGFAIALWSGSRAVNVFIDTITVMYGLDGQRGIVKTR
                     LLSLVLYIVALLIGAVVLPLAVVGPDRVVELIPWGTDVISFLYWPTMILLSIAFLTTLF
                     HVSVPVRSPWIEDVPGALVALAMWVLGSFLLRIYLTSTVEGPTIYGSLAAPIAVLLWIG
                     ISAFAVLVGAAVNAAIDRVWPSVATAAARAAGERARAAQAAQIVARAHVQPMLFGEEDE
                     EDEEDGEDGNDPGMPSEFPERWSKFLPPEDVKSRLHTVKKHEDKPQDPSARDPHKGPRD
                     HD"
     misc_feature    15626..15635
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            15689..17335
                     /locus_tag="DWB77_RS08870"
                     /old_locus_tag="DWB77_01780"
     CDS             15689..17335
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310257.1"
                     /locus_tag="DWB77_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01780"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_120720728.1"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.8e-18, bitscore:
                     65.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.1e-32, bitscore:
                     111.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATTHTVTNQAPPLVGYDVFTADRVLGEAVERHTAPELVDEVTE
                     ELATLGRSAGSAQAQEWGVLANENPPKLRTHDRYGNRIDEVEFHPSWHRLLGKAVTSGL
                     TDAWGRPAGHVRRAAGFLVWTQAEGGHGCPVSMTHAAVPALRTDPALAAEWEPRLTSHV
                     YEEGLRPAAEKAGVIFGMGMTEKQGGSDVRANTTVATPLAADGEYVLTGHKWFCSAPMS
                     DGFLVLAQASPSKKDSLTCFLVPRVLADGTRNAFAIQRLKDKLGNKSNASSEVEFDGTW
                     ARRVGEEGRGVRTIIEMVAATRLDCVIGSAAIMRQAVTQAVHHASYRRAFGGLLVEKPL
                     MRNVLADLALESEAATTLALRLAAAYDADTEEERAFLRLAVPAAKYWVTKRCTPVAGEA
                     LECLGGNGYVEESGMPRLLREAPLNSIWEGSGNVQALDVLRALQREPQAINAFLQEVGK
                     ARGADHRLDAAIKNLLTELADLDGIEGRARRLVERMALVLQGSLLVRWAPAEVADAFCA
                     SRLGGDWGAAFGTLPHSLDLASVVERARAEV"
     gene            17735..19045
                     /locus_tag="DWB77_RS08875"
                     /old_locus_tag="DWB77_01781"
     CDS             17735..19045
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890257.1"
                     /locus_tag="DWB77_RS08875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01781"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_120727551.1"
                     /transl_table=11
                     /translation="MLDVARLAAMDAQEAARLLTRVRAATLAGRDSKVAPRTEIGESWR
                     RALNSGLDPDGDNRAGLLSLAEVERRRRRSPLAEVLPVLRDALVSVADAAQHIMVVSDA
                     EGRLLWREGHPSVLKLADALGFEVGADWSEAAVGTNGVGTPLVTGRPVQVYSAEHFVAS
                     HHTWTCAGAPVVDPRDGRLLGVVDISGPLGTMHPATLSFVTSVARLAAAELRNRHFAAL
                     ERLRTAAAPVLCRVGGRALAVDDNGWVAAVTGMPPLDRLALPKVPRAGRVWLPSLGMCA
                     VEPLPGGRLVRVCEEADGSDTATARRVVLDVSRPRRCSVTVSGDTGSWTQELSPRHAEL
                     LFVLALNREGLSAAQLARDIFADPTRTVTVRAEMSRLRRHLAEVLAHRPYRFSEDVRVE
                     VVRPDHAADLLPHSLSPSIARARGGHQRPAWQASEAP"
     gene            19059..19622
                     /locus_tag="DWB77_RS08880"
                     /old_locus_tag="DWB77_01782"
     CDS             19059..19622
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890253.1"
                     /locus_tag="DWB77_RS08880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_01782"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_120720729.1"
                     /transl_table=11
                     /translation="MSITVTTWSLEQTAVTDLRPAAEPADGFTIVRAEVPSPEFSRFLY
                     TAVGGDIKWVDRLGMTYEAWERELNRPGTETWVAYDRGTPAGYVELQAQPGGSVEIVYF
                     GLIPAFRGRRMGGPLLTYGTRRAWDLAERWPELPATERVWLHTCSLDGEHAMDNYVRRG
                     FKLFATVEEQVAEVAAPGPWPGAF"
     misc_feature    19071..19086
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.38"
                     /tool="antismash"
     misc_feature    19708..19721
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.67"
                     /tool="antismash"
     gene            19744..19827
                     /locus_tag="DWB77_RS39445"
     CDS             19744..19827
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042934.1"
                     /locus_tag="DWB77_RS39445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative leader peptide"
                     /protein_id="WP_310591794.1"
                     /transl_table=11
                     /translation="MSGTGIALVSRRHVDLGRMSSAICPAR"
     misc_feature    20088..20102
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(20135..20148)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     misc_feature    complement(20144..20158)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(20393..20406)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
ORIGIN
        1 gaccgaagcg gatgtaatgg gcaactattt agcttcgatc gtgtggtgcg gaggtatggg
       61 gcgtcaacgg ggtgaggggt gaaatggctt gtaaatgggg gttgttggcg gtcggcgggg
      121 gttttccgag ttgggttacg ggctgaccgc gaggacgatg tacgcggcga acaaggagag
      181 gtgcaccccg ccctgcatca gggtggcgcg gcccggtacg acggtgagga tgccgaccgc
      241 cacggtcagc gcgagcagca ccatgtggct ggcgcccagg ccgaggacga gcggcccgga
      301 cagccagatc gtggcgagag cgacggccgg aatggtgagg ccgatgctcg ccatggccga
      361 gccgagcgcc aggttgaggc tggtctgcac gcggtcgcga cgggccgcgc gcaccgccgc
      421 gatggtctcg ggaagcagca cgagcagcgc gatgacgacg ccgacgaccg aggcgggcag
      481 ccccgccgcg gccacccccc gctcgatggt gggcgagacg cccttggcca ggcccaccac
      541 cgcgacgagc gccaccccga gcaggatgac gctggtccag gcggtgcgtg cggagggcgg
      601 gttggcgtgc gcatcgtccc gcatcacctc gccctgctgg gtgaccggca ggaagtagtc
      661 gcggtggcgc accgtctggg tcgccacgaa gagcccgtac aggaacaccg acgcgatcgc
      721 cgcgaagatc agctgggcgg gcgagaactc cgggcccggc ttgctggtgg tgaaggtcgg
      781 cagggcgaga ctgaggcccg ccagcgtggt gaccgtcgcg aacgcggtga cggtgccctc
      841 ggcgttgaag acggccagtc ggcgccgcac ggcgcccacc aggaggcaca ccccgacgat
      901 gccgttgcag gtgatcatca cggcggcgaa gacggtgtcg cgggcgagcg aggcgctctt
      961 gtcgccgccg tccgacatca gggtgacgat cagggcgacc tcgatgatgg tcaccgcgac
     1021 cgcgagcacg agcgacccga acggttcgcc cacccggtgc gccaccacct ccgcgtggtg
     1081 caccgccgcg agcaccgcgc cggccaggaa acacgcgacc agcgcgacga gcacgccggg
     1141 cagcgaacgg ccccacgtca gcgcgagcag cacgacggcg agcggcggca tcaccgccga
     1201 ccagcggtcc aggggcaggc gcgcgagacg gatcatgcct tcgacgttct cagaagtggc
     1261 ggcgccccgc ccgtcggacc acggcgtcgg actaccgccg cccggccgcc gcgaccgcca
     1321 ggtggcggcg cgcgtaggag cgccagggcc gccaggcgtc ccggtccgct gggcccacgt
     1381 ccgggtcgcc gagcgcccgc gtacggatca cctggacggt ctcctcgtcc atgccgggca
     1441 gggtgcgcag cacgcgggcg gcctcgtcgc ggtcggcgcc ggcgtccagg cgcagggtgg
     1501 cgtcggcgag cgcggtcgcc agggcggcga ggtgcggatc ggggtggggg gcgagcgtgg
     1561 cggagtccgg gaacagatgg gtgagcgtgc cgcagggcac gtcgagccgt ttgccgtacg
     1621 tctcgacgag gcccgccgcg cgctgctgcc cgatcagcgc ccgcaccgcg cactcctcgg
     1681 ggtcggccgc ccccggcgag cgaagccctg gggtgcgggc gacgagcggg gcgagacggg
     1741 ggtcggcgcc gagccgctcg tcgacggcgt acgggtcggc gtccaggtcg aacaggcggc
     1801 gcaggcgctg gacggcggtg gtcagatcgc gcaggtcggt gaggtggatc cgggcgtcca
     1861 gccagccctg gcgggccgcg gtgtgtgcgg gtgcggcctc gtcgacggcc acgacggcgg
     1921 tgccgtgggg caggcccagg gtgcggcggt aggtgcgggc tccgctcgcg ccggcgacct
     1981 cctcgacgtg ctcgacggcc tcggcggcca gcaggtcgaa ggtctccttc accgcgtacg
     2041 cgccccggtg ggcgagccgc agcgggatcc cggccgcggc cgcgacaccg gctctggtgg
     2101 cccgggtgcc ggcctcctca cgcaggccgc tgggcgtacg ggcgtagatc tgccggatcg
     2161 tgtcgttgaa ctggcgcacg ctcgcgaagc ccgaggcgaa cgcgatctcg gtcaccggga
     2221 gcgaggtggt ctggagcaac acccttgccg cgtgggcgcg ttgggcccgg gcgagcgcga
     2281 ccgggcccgc gcccacctcc gcggtgagct ggcgctgcac ctggcgggcg ctgtagccca
     2341 gccgggtcgc cagacccggc acgccctccc ggtccaccac gccgtccccg atcatgcgca
     2401 tggcccggcc cacgacgtcg gcccgcgcgt tccactcggc ggagccgggc acggcgtccg
     2461 ggcggcagcg gcggcacgcg cggaagccgt ggttctgggc ggcggcggcg ctcgggaaga
     2521 accggacgtt cttgcggcgg ggggtgacgg cggggcagct cgggcggcag tagatgccgg
     2581 tcgtcgcgac ggcgaagaag aactcgccgt cgaaccgggc gtccctgctg gtgaccgcct
     2641 cgtacgcggc gtcgtggtcc atcacgtctt ccagtgtgcg gggtcccctg ccgggcggct
     2701 ggcggctttc ggaccccgcc ccccttccct ggggctccgc cccagacccc gggcacctcg
     2761 cccacccacc cgcccgttac gggggttgga tagccccggg tccctggggc tctgccccag
     2821 accccgttcg cgccttaagg gcgctcgtcc tcaatcgccg gacaggctga ggtgctggcc
     2881 agcaccgaat agttaagggg cgcgaggaac tgcgcgagaa gccagcacgg tccgcaggtt
     2941 cgagagggtt taggggcgcg aggaactgcg cgaccagcca cccacggccc gcagacgaaa
     3001 acgggtctcc aggggcgcga ggaactgcgc aaaagcgacc acggcccgca ggttcgagag
     3061 ggtttagggg cgcgaggaac tgcgcgacca gccacccacg gcccgaggac gaaaagcggg
     3121 tttctagggg cgcggggaac tgcgcgacca gccccgcacg gtccgcagcc gtaagggggt
     3181 gcaggggtgc gggggcaagg gcctccccca gcagcccgca ccccgcacct caagacactc
     3241 cgcgcccccg cttgagcact ccgttcgccc gcccctccgc cccccgcaac ctccactccc
     3301 tccgaagctc cgcccgcacc cgcgcatccg tcttcgccac gatccgctgg ttctcgcgca
     3361 gcagcttgcg gtaactgtcc aggcggcgtt ccgacaggga gccgtcctcg atggccgcca
     3421 gcaccgcgca gcccggttcc gcctggtggg cgcagtcgtg gaagcggcag tccgtggcca
     3481 gttcctcgat ctcggcgaag acctggccga cgccggactc cgcgtcgtac aggccgacac
     3541 cccgcagccc gggggtgtcg atgaggacgc ccccgccggg cagcaccagc aggttgcggg
     3601 tggtcgtggt gtggcggccc ttgccgtcca cgtcgcggat ggcctgcacc accatcacct
     3661 ccgcgccgag cagcgcgttg gcgagcgtgg acttgcccgc gccggactgc ccgagcagca
     3721 cgctggtgcc gcccgcgacg accgcggcga ggatgtcgat gccctcgcgg gtggtcgcgc
     3781 tgaccggcag gacctgcacc ccgggcgcgg ccgtttcgac gtcccggacg aggtaggaga
     3841 gcccgaccgg gtcggggacc aggtcggcct tggtgagtac gacgagcggc tgggcgcccg
     3901 attcccaggc cagcgccagg aaacgctcga tgcggccgag gtcgagttcg acggcgagcg
     3961 acaccgcgat gatcgcgtgg tcgacgttgg ccgccaggat ctgcgcctcg gaccggttgg
     4021 aggaggtgct gcgcacgaac gcggtgcggc gcggcagata cgcccgcacg aagcgcgggt
     4081 cgccgcccgg ttcgacgacg gcccagtcac cggtgcagat cacccgcatc gggtcgtgcg
     4141 gggtgacgta cgcggtgtcg gcgcgcaggg tgccgtcggc ggtcgccacg tcgcactggc
     4201 cgcggtcgac ccggacgacc cggccgggca ccaggccctg ctcggcgtac ggggtgaact
     4261 cggcggccca ggcgtcgtcc cagccgtacg cggcgagcgg gcgcgacggg gcggaggtgt
     4321 tgaaccccga ggtgccgaag gcggaggtgt tgaacggggt ggagaacgag gaagacaagg
     4381 gggacccttc gaagggcggt cccggcggcg cgctgtgggc gcgcggtacg cgtgggtgtc
     4441 agccggagac cacaggggtg ggaacgatga actcctgaat gcgggcagtg cccgtcacca
     4501 tgaccgtcat caatgtcctc acctcctgct tctgctcaac gaaccgaccc cgctcgccgt
     4561 cgcgcgagcg gatgagcaca accctagcca cgcccccggc acggcaccac cgaattaatc
     4621 ggccccggca aggcccttcg gcgcggtggg agcctggggg catgaacgac ccgacgcagg
     4681 acccccgctt ccaccaggac ccctatcccg cgtacgccgc cctgcggtcc aggtgcccgg
     4741 tgcagcgcct cgccaacggg cccgacgggc gcgccagtta tgtggtcacc ggctacgcgg
     4801 aggcccgcga ggcgctcgcg gacgctcggc tgtcgaagga cacggcggcc ttcttcgcgg
     4861 gcaagggttc gtcgcggcgc ctgcatcccg cggtggcgcg gaccatgctg gccagcgatc
     4921 cgccccggca cacccggctg cgcaagctgg tcacgaaggc gttcaccacg ggtgccgtgg
     4981 cggagctgcg tccgttcatc gcccacgtca ccgacgagtt gctggatcgg tggccggtgg
     5041 gccaacaggc cgacttcgtg gccgacttgg cggttcctct gccggtcgcc gtgatctgcg
     5101 agctgctcgg ggtgccgcag gacgaccggc cggatgtgcg gcgctggtcc ggggagctgt
     5161 tcgcggcggg acgacccgac gtcatcgacg cggcctcgca tgcgctcgcc gactacatga
     5221 ccaacctcat cgccgcgaag cgcctgcgcc cgggggagcg tcttctcgac cggctcatcg
     5281 cggcgcggga cggcgacgac cgcctgtcgg aggaggagtt ggtctccctc gccgtgctgc
     5341 tcctcgtggc cgggcacgag accaccaccc acttcctcgg caacgccgcc ctcgcgctgc
     5401 tccggcaccc cgccgcactc gaccgtctcc gggcggatcc ggacgggatc cggaccctgc
     5461 tggacgagct gctccggtac gactcccccg tcagtacggc cacgttcagg ttcaccaccg
     5521 aggccgtcac gctcggcggt acggacattc ccgccggtgt ccccgtcctg gtcgcgctcg
     5581 gagcggccaa ccgcgacccg cggcggttcc cgtcgccgga cctgctcgac cgggaccggg
     5641 acgccgccgg acatctcggc ttcggccacg gcatccaccg ctgcgtcggc gctcccctgg
     5701 ccctggccga ggccgagatc gcgctgcgcg cggccctggt gcgcttctcc cgcctccggc
     5761 tcgccgtggc gttcgagcgg ctccagtggc ggcgcacccg gctggtgcgc gggctgacct
     5821 cgctgcccgt cctcacgtaa ccgctcggcg ctttccgtat cagtggtggt agatggcgat
     5881 gccgttgggg acgcgccgtt gctggccgtg gtcgagcgtg ttgcgtacgg tcgtgcggcc
     5941 cgtcgcgggg tcgcgggtga cgagcgtggt ggaggcgccg ccgtcgagga agacgccctc
     6001 gtcgcaccgc aaggacgcca ggaatcgggc gagttcggcg acggtgagcc cggtggcggt
     6061 ggattcgcgg ccgtcggtgg ccaccaggcg cagcagatgc ccgtcgtcgg cgatcgcggc
     6121 ggcggtccgt ggctccgcgg tgacgtcgtc caggccgggc agcggcgccc ggtccttgag
     6181 gagcgggtag gcgccgaggg cgaagtcgaa cggggtgaca ccggtcgagt cgaagcggta
     6241 gtcgaccgag acgggcgtgc cgggcgtcag ggagcgcagg gcccgcgcgc cctgttcgcg
     6301 cccgagcagg acgagcgagc cggccgggac ggggccgctg cccggggtcg tggcggtgtc
     6361 ggcgacgcgc ccgtcgcgga cggtgacctc gaaggtgtcg cgggtgcagg gcgcggcgcg
     6421 tttgtggtcg gttccgcagg ccgctcgcgc gcgcgagacg ctgccccagt ccgggttgaa
     6481 gaccccgatg gagccttcgg gaagggcgta ctggttgagg cctttgagcg ccaacgagcc
     6541 ttgtgggggg tggagttgac cgttcagggt gaggcgggcg gtgcgggcgc ggccgtcctg
     6601 gccgacaccc aggacgtcct cgccggacgc gccggccggc atcttccagc cgaaccgctg
     6661 gccttggggc accgccccct tcaggggctg cccgtgcagg acggcggcgc ctgacgccga
     6721 accggtggcg gcgacgccgg ggtgctccgc ttcggtcatg ttgaagaagt cgccgttgat
     6781 ggcggcgacc gccccctgct gctcggccat ggcggacacc ggtgcccggc cggtgaccgt
     6841 gccggcgtgc agcagaccgg cccccactcc ggcgtggcgc aggtcgacgg tcaccacgtg
     6901 gaccctgctc gggccgtggc cggtcgtcag ggtgagggcc tggtagtcga cccccggggc
     6961 gatgtgctcg acggccgggt cgatgtgctg gagggccggg gcgatgtgct ggagggccgg
     7021 gtcccgcgcc gcgtccgtgg cccgtgcggg gcggccggca ccgacggtga gggtcgtggt
     7081 gagcgtgagc aggaagacgg cggcgacagc gatgcgaacc cggttcatgc cgccaccgtg
     7141 gtgccggtgc gggacgcggc tcgggaggcg cgcgtgccgg tcgcccggcg acacccgcgc
     7201 gggcgcaccc cgcgtggcgc cgctgaagcg cgcgacggtc aacggcacgt ctcgtcctcg
     7261 ggggcgtact ggttcgcctg gaggtggtag agctcggcgt agagcccgcc ggccgccaac
     7321 aggtcggcgg gcgcgccgga ttcgaccagg cggccctcgt ccagtacgtg gacgaggtcg
     7381 gcgtggcgca cggaggcgag ccggtgggtg atcaggagga ccgtgctgcc gtcctcggcg
     7441 agggagcgga tctcgtcgaa gatctgtagt tccgcccggg cgtcgagcgc tgcggtcggc
     7501 tcgtcgacga tgaggatctg gcccggccgg ccggcggccc ggtaggcggc gcggccgaag
     7561 ccgagccgct gccactgtcc gccggacagt tggtggccgc cgcggaaccc ccgggcgagc
     7621 agggtgtcca gaccgcgggg cagtccggcg acgaggtcct cggccccggc gtggcgcagg
     7681 gcgcgctcga cgtgctcgtc gtgtgcgggg gcctcggggc ggccgatgag gacgttgacc
     7741 cgcgcggtga aggcccagcg ggtgaagtcc tgcgcgacca tcgccacccg gtcggtcagc
     7801 tgccgccggt cggccagggc ggcatcgacg tcgtcccaca ggatgcggcc gcgctgcggg
     7861 gcgtagaggc cggccaggag cctggccagg gtggtcttgc ccgaaccgtt gctgccgacc
     7921 agcgcgacga tccgtccggt gggcagggtg agcgtcacgt cgtccagggc cggcgtcccc
     7981 tcccccgggt aggtgaacgt cacctgctcg aagcggatca ggcgcggcgc ctcgggcagc
     8041 gccacacctc ccggcgcccg ggtgcgccgc tcggcctcct cacacaggcg ctccaagtcg
     8101 ccgacgaaca gggcctgttc atggagggcg ttgacctcca gggcgagcgt ggtgaggctg
     8161 gccgagccgg tgcggatggc gatcacggcg gtgccggcga cggacagagc catcgccccg
     8221 ccgaggagca gggcgcccaa agtcgcgtag gtggcggcgg ttgcgacgcc gatccacccg
     8281 gcggcgatca gtcccgtacg ggcttcgagc cgggccagcc gggactgttc cgcctcggcg
     8341 gattcggcga gggcgcggaa gtggcgcagc aggaacgggc cgacgccgtg cacccggatc
     8401 tcgggcgcgg caccggcgtc ggtcagcatc tgtccgatga gcgcgcccgc ccgggtgtgc
     8461 tgggtccagg cgtggaagga cagatagcga cggcgggcgg tggtgagcgc gctccaggag
     8521 ccgggcagcg tcatgacggt cagcagcggc agcaggacgg ggtgcagcac ggtgaggacg
     8581 cccgcggcgg tgacgaagga gatcgcggcg ctgatgacgc ggttgccgat gctcatcatg
     8641 cggcgcgcgg aggacgcccc gtagcgcgcc gaatcgagca gcttgtggaa ctggtcgtcc
     8701 tcgatggccg ccagctcgac ccgcgaggcc cgttccaggt agacctcggt cgccatccgc
     8761 tcgacccgcg gttcgaggcg tccggtcgcg tacgtggaaa cggcccgcag cagcgccccg
     8821 gcggacagac agacgccgac cgcgacgagg gcgccgagca cgccgcgcag ccgctcctcc
     8881 atggtcccgc cggtcatcag cccggccagc acgcggttga cagcgagcag gctcgcggcc
     8941 tgggtgagcc cccggcccag gttggcggcg acgaggccgc gtgcggcgcg cggatcggca
     9001 cgccacgcca gccggaaccc cgaggcgagg agccggggca gccgtctcag cacggcgcgc
     9061 aggttcagag ccagataggc ctcttcgtgc tgggaccagc cggtgtcgta gcgcaagggg
     9121 ccgccgaaca ggagctgttc ggaatccgag ggccgctgcg cgtcctcgtc gggcgcgggg
     9181 gccgtgcggt cacggcgtgg tcggcgcacg cggggtcagc cggtgagggc ggcggcggtg
     9241 aacaccagcg ccgggtaggc cccgatgaac gcgaagacga acgtggtgag ccccatggtg
     9301 aacgcgatgc cgaggtgcag ggccgcgccg gcggcgagca gcccccagcg cgggggcccc
     9361 ggcacgacga gcgcgagcca gaaggtgacc tcgaggacca tcacgcccca cgccatgagg
     9421 gcgcccaccc agggtctggc gcgcaggaac gcggcgatcc ccggcgagcc gtaggagtcg
     9481 gtggagagga tctgggcgag gcaggagccg tcgcgccagg tcggcgagac cagtttggcc
     9541 actccggcga tgagatagct caggatcaac tggccggtga ggaaggcgag gaagagccgg
     9601 cccaccgtgc cgccgacggt cagggtgacg gcggcggtga gcatggcgag ggccgccatc
     9661 tggtccgcgc cgtcggtgcc gtagtcgctg cggtgcaggc cgaggaggag cgtggtcagc
     9721 aggacgcagg ccactacggc cgagccgggt gcggacagcg cggccacggc cggggcggcg
     9781 aggccggcgg cgcactgcac cgccagcacc gcccggtagc ggtcccccac gaagagggcg
     9841 cgcaccgccg gcgggcagcg gtgcgggtag gcgccgacca ccgcccacgc cagggcgccg
     9901 cccgcaccga actcgtggct ctgccgcagg tcgcggccgg ccgacaccgc gaggcccact
     9961 ccacagacgg ccaggatcgc gcgggccgtc tcggtctcgt tcagcatggg gtcccttccc
    10021 gcacggcgcg ccggcccggc ccgccgtgcg ccaccgcgcc gctgcccgcc gcgcccttga
    10081 ggcggtgcac ggcggagacg aagaccacct cgggttcctc gtcgcgtcgg ctcgcgtgcg
    10141 cgatgacgaa ctcgaagctg acggcggtgg cgtcgtgcgg cgccgtggcc gccctgttca
    10201 ggaggaggag gtacggggtg ctgatcatca accgggcgtc cctgatccgg gcgtcgggct
    10261 cctcgtccca gcccgctgcg gcccggcgca gcagctgtga cgccgcgtcg aacagcgcct
    10321 tgccgggtct gccccccgcg ccgccttccg gcaggacgag gcgcaggggg ccgacggtgt
    10381 cgttggcgag gatgtcccgg tacatcagca ccttgtcctt cgtcgccggg ttgggtgcga
    10441 agaacgtcca ggcgggcagg agcggggcga accagtcggg gacgtgccgc tgggtggcgg
    10501 tgccgatccg gggcagcgcc gccaccacgg tcaacagcag ccacccggcc agtacgacgg
    10561 ccacaagcgc ggggaccacg ggggcggccc gctagtacga gaagtggcgc cggcgggtcg
    10621 cgagcagatc ggccaccgcg gccgcgggct cgcccgactc acccgcgatc tccgtgatct
    10681 cgctctgcga cagcgccgtc gcactctcgt cccgggcgta tccgccgcgc gcgtgcttct
    10741 cgcggaccgc ctcctgcgcc gcccggccga tgccgtcggt cagcgcgtcc atcgcggtca
    10801 gggtctggca cggctggggc cggcgcatgt ggacgtggcg ctcctcggga tccatgtcgt
    10861 cgagcaactg ccgttccagg cgcgtcagtt cgggtgcccg gcgcatcagc agacaggtgg
    10921 tgcggaccgc gggggtgccg ccgtcggtgt gctcgacgat gccgaagtcg gcgtcccgga
    10981 tcgggccgcc ggtgtagggg aaggtcagcg tcctgaacgg gactccgtgc gggagggcca
    11041 ggccgtgcgc caccacatgg cccgcgcaca ccaggtcgaa gggtgtcgac gcggcggtca
    11101 actcggcgcc cggattgggg tgttggggta cggcggtgtc ccggacggcc tgccagtcgc
    11161 cgtcgagcgc ggccgcgcgc agccggtgcc actcgggcgc cgcggcgtct cccacataga
    11221 tcacgacggt tcccgccggc ggcagcaggc cgccgtccgc cactcccgcc gcgtcggtcg
    11281 gcacggtcac cacctgcacg ctcttgaccg cggccgccgt tgtcgaagcc agcatcatgc
    11341 ccatctcctg tcccgggccg atcccggacc agtgccggtc cggggcgggt tcctgtgcgt
    11401 tcgctgtgaa cccggcgacc agtctcgcgg cgtgcccccg tcctcgacac cccccgaatg
    11461 ttggggggtt ggcgcgggct ttcgtacccc ctttcctgag ttgcgtacgg cccaaaagga
    11521 ccggcgtcga ggcggaagca ccactggacc gaggaagcga ggaacggccg acatggctga
    11581 atcgaagcgg gacatcaggg aaccgggatc gcacgagccg aacagcccct cccggagcgc
    11641 ctatctgcgg ctgctcgcgc tgcaacgcgc gggagagccc acggcgccgg cgggcgtcga
    11701 ggaggccggg cagcagccgg aacggctgga gcggcaggcg atcgtcgacg agttgcgtcc
    11761 gccggtacgc atgtggcccg actacccgga cttctgggtc gagagccctc gcgggggcgg
    11821 cccctggcac gagcggttcg gagacaaggg accgcgtcgc tcgggctccg tcgcccgccg
    11881 cggcggtcag gaacccgcgc cgagccggat gagcgtcagc gaggcgtttc tgcggctgag
    11941 gctgaccttg ggcgccgagc ccgcatgagt gtcgacgcct ccccgcagcg gggggaggtg
    12001 ggggcggcgg ggcgtgagcc gatgccgccc tacctccaac tggtcgtcaa ggtctcgaag
    12061 ttctgcaatc tgcgctgtcg ctactgctac gagttcccgt ccctcggcga ccgggccgcg
    12121 atgacggtgg aacaggtcag gaacatgatc cggcacgtgg gcgagtggct cgcggaccag
    12181 ccgggcagaa ccgcggactt cgtgtggcac ggcggcgagc ccctgctcat gccgcccgac
    12241 ttctaccgcg aggtcaaacg ggcccaggag gagttcctgg agcccgcctc cattccgtac
    12301 ggcaactccg tccagaccaa cctctaccgg ctgaccgacg acgacctcgc cctgatgagg
    12361 gacgtcttcg acgacgtggg tgtctcggtg gacctcgtgg gcggccagcg ggtgaacgtc
    12421 gccggccgtc aggcgcagcc gcgggtcctc gcccatatgc agcgcctcat ggacgagggc
    12481 ctgaacttcg ggtgcatcac cgtgctctcc cgctccacgg cgccccatgt cgcggagatc
    12541 caccgcttct tcgaggacat gaacctgggc tttcggatgc tgccgatcta ccggacgggc
    12601 tatccggggc agcaggccga gcacgaactc tcggcgcagg agatcgtcga ggcgttcaag
    12661 acgctcaccg accggtggct ggtctcggac agcttcatca acgtcgagcc catcgaaggc
    12721 tatgcggccc aggtcgtcca cgccctgtcg ggcgcggaca accgtcgcta ctacgacaag
    12781 gagctctcgg agaccatcct cgtcatcgac acggacggtt cggtgtactc caacggcgac
    12841 gcctacgacc cggcgctgtg ccacggcaac atcttcaccg actcgctctc ctcgacgcgc
    12901 cgctccgcct cgttcgccga ggcactgcgc cagtcgcggc agcgggtcac ggacacctgc
    12961 accggctgcc gcttccacgg ctcctgttcg ggcttcttcg ccgcggagtc cacgccggaa
    13021 cagcggtggc gggaccccgc gaccggcctg tccgtgtgcg gggtggtgct gcccgttcag
    13081 gagtacatcg aggagcggct cacggcgctc gggctcgtgg acggcgtgac ccgccggctc
    13141 gaccgcgccc tgctggaacg gcgggcgctg gactgaacca cccggcacac aagagaaccg
    13201 gcgggtcgga gcgccgggcg ggatccgcgc gagagcgtgg ggccgcccgg cgcgctcgtc
    13261 gtgttactgc cgcaatccgg cgatgagctc ctcgcggccg cccgtgcccg tcttgcggta
    13321 gaccgagcgc agatggccgg agaccgtgtg cggggacatg ccgaggagcc gggcgatgcg
    13381 tttggtcgcg aggcccccca ggaggcactc gacgatggct tgctcgcgcg gtgtgaaccc
    13441 gtaccagacg aagatcgccg gaaggagttg cgaggcgggg gcggactgga aggtgatgac
    13501 gatgtccccc tcctccttcc cgtcgagcaa ctgcgcgtgc accgcgaccc accccccgcc
    13561 ggtcgggatc ctgctgagcg cggtggtgtg ggtgcgccgg gtgaagtagg tgatgcccca
    13621 gagcagatgg ggcagttcgt cgtccttggc aggcggggtc tcggggagga actcgtgcag
    13681 ccaggtgcgt gccgtcgacg tcatgccctt gatcgtgtcg tcggggccga tgacgatcac
    13741 gccggggaac agtccgcgcc ggcccgggcg cagcggtttg ccggccacgt actgccgcag
    13801 ggcggccgag agcgggcccg cgagccgctc ggcgcaccgg gcctccgcct ccgagaacgg
    13861 ggtgccgtcg cctccccgca gcaggaccag gccgccccac accctcccgc gcagggtcag
    13921 cgcgatgggc agctcgcttc cgggcccctt cgagggccgc aggtcgtggt ggaggcagcc
    13981 gacgccggtg agcggatcga ggccggccag cgtgtggccg tcgtgcggca ggaaagggtg
    14041 gagcagccgg gacagctcgg tggcgagctc ggccacggtg gtggcccggg ccgcggcggc
    14101 cagcagttgg cgccggaact cttccgcctc ggtgacgctc ccacggaggt caggcatacc
    14161 ccgctccccc ggattctggg attcccgcct tctgcgtgag tcgctccgta tagctctccg
    14221 gcccagctcg gcccatgcac ggcgccactc atgtgggcga cgcgggatca ggacagcttg
    14281 ccggggacga acgcgccgtc accgggcccg cttgcaccgg gcccaccagc gccaacgccc
    14341 tcgggcgata cggcgagggc caccacggac gcctcctcca ggagggcccg cacgcccggc
    14401 ccggccgccc ggtagaagat ccgcgtgccg tcccggcgcg aggtgacaag gccggcccgc
    14461 cgggttcagt cgtggtcgcg cgggcccttg tgggggtcgc gcgcggaggg gtcctgcggc
    14521 ttgtcctcgt gcttcttcac ggtgtgcaga cgggacttca cgtcctcggg cggcaggaac
    14581 ttcgaccacc gctcggggaa ctcggagggc atccccgggt cgttgccgtc ctcgccgtcc
    14641 tcctcatcct cctcgtcctc ctcgccgaag agcatcggct ggacatgggc gcgggcgacg
    14701 atctgggcgg cctgcgcggc ccgcgcccgc tcgccggccg cgcgggcggc ggccgtcgcg
    14761 accgagggcc agacccggtc gatggccgcg ttgacggccg cgcccaccag caccgcgaac
    14821 gccgagatgc cgatccacag gagcaccgcg atgggcgcgg ccagcgagcc gtagatggtg
    14881 gggccctcga ccgtgctggt caggtagatg cgcagcagga acgagccgag cacccacatc
    14941 gcgagggcca cgagcgcgcc cggcacgtcc tcgatccacg gcgagcggac cggcaccgag
    15001 acgtggaaga gggtggtgag gaaggcgatg gagagcagga tcatcgtggg ccagtacagg
    15061 aagctgatca cgtccgtgcc ccacgggatc agctccacca cccggtccgg gcccaccacc
    15121 gcgagcggca gcacgaccgc gccgatgagc agcgcgacga tgtacaggac cagcgagagc
    15181 agccgggtct tgacgatgcc gcgctggccg tcgagcccgt acatcacggt gatggtgtcg
    15241 atgaagacgt tgacggcgcg cgagcccgac cacagcgcga tggcgaagcc gatggagacg
    15301 atctccgggc gcttgccctg ggtcacgtcg tcgagcagcg gctgggcgaa ctcgtgcaca
    15361 ccgcggtcgg agagcacggt tccggccgcg ttcaaaatgt tctgctcgat gctggcgacg
    15421 gtgtgggtgc tggtccagcc gtccacgtag ccgagcagcg cgatgacgct gagcagcagc
    15481 ggcggcagcg agagcagcgt gaagaacgcg gcctcggcgg ccaggcccag gatgcggtac
    15541 tcgacacagg agttgacggt gtccttgagg agcagccagc ccaatttccg cttggagacg
    15601 ttgcggtaga gcacacgggc ccgatgaagg cggccggatg tccgctcggg tgtttcattt
    15661 gctggctgca cgtccttacc gtatcggcat ggcagccacc acccacacag tgaccaacca
    15721 ggctccgccc ctggtggggt acgacgtctt caccgccgac cgggtcctcg gcgaggccgt
    15781 cgagcggcac accgcgccgg agctcgtcga cgaggtgacc gaggagctag cgaccctcgg
    15841 acgttcggcg ggatcggccc aggcccagga gtggggtgtg ctggcgaacg agaacccgcc
    15901 gaagctgcgc acccacgacc ggtacgggaa ccggatcgac gaggtcgagt tccatccgag
    15961 ctggcaccgt ctgctcggca aggccgtgac ctccgggctc accgacgcct gggggcggcc
    16021 cgccgggcat gtgcgccggg ccgccgggtt cctggtgtgg acgcaggcgg agggcgggca
    16081 cggctgtccg gtctccatga cgcacgcggc ggtgcccgcg ctgcgcaccg acccggcgct
    16141 ggccgccgag tgggagccgc ggctcacctc acacgtatac gaggaggggc tgcggcccgc
    16201 cgcggagaag gccggagtca tcttcggcat gggcatgacg gagaagcagg gcggcagcga
    16261 cgtacgggcc aacaccaccg tggcgacccc gctcgccgcc gacggcgagt acgtgctgac
    16321 cgggcacaag tggttctgct cggcgccgat gagcgacggg ttcctggtcc tcgcgcaggc
    16381 atccccctcc aagaaggaca gcctcacgtg tttcctggtg ccgcgcgtcc tcgccgacgg
    16441 cacccgcaac gcgttcgcga tccagcggct caaggacaag ctgggcaaca agtcgaacgc
    16501 ctccagcgag gtcgagttcg acgggacgtg ggcgcgccgg gtcggcgagg aggggcgcgg
    16561 ggtgcgcacc atcatcgaga tggtggcggc gacccggctc gactgtgtga tcggctcggc
    16621 ggcgatcatg cggcaggcgg tgacgcaggc ggtccaccac gcctcgtacc gacgtgcgtt
    16681 cggcgggttg ctcgtggaga agccgctgat gcgcaacgtc ctggccgatc tggccctgga
    16741 gtcggaggcg gccaccacgc tcgcgctgcg gctcgcggcc gcctatgacg ccgacaccga
    16801 ggaggagcgg gcgttcctgc ggctcgcggt gccggccgcc aagtactggg tcaccaagcg
    16861 gtgtacgccg gtggcgggcg aggcgctcga atgtctcggg ggcaacgggt acgtcgagga
    16921 gtcggggatg ccccggctgc tgcgggaggc cccgctgaac tcgatctggg agggttcggg
    16981 caatgtccag gccctggacg tgctgcgggc gctccagcgc gagccgcagg cgatcaacgc
    17041 cttcctccag gaggtcggca aggcccgcgg cgcggaccac cggctcgacg cggcgatcaa
    17101 gaacctgctg accgaactcg ccgatctgga cggcatcgag ggccgggccc gtcgcctggt
    17161 ggagcgcatg gcgctggtgc tccagggttc cctgctggtg cgctgggcgc cggcggaggt
    17221 cgcggacgcg ttctgcgcct cgcggctcgg cggcgactgg ggggcggcct tcgggacgct
    17281 gccgcactcg ctggatctgg cgtcggtggt cgagcgcgcc cgcgccgaag tgtgagacgg
    17341 gccccgcgcg gagatgtgag gcgggccccg cgccgaggtg tgcggcggcc cccgcatcga
    17401 ggtgtgaggc gggccccgcg ccgaggtctc gggacggccc cgagcgcggc cgaaagccgg
    17461 tgcccggggc ggtccgtcgg gggtggtgct gcgccgacac ggcaccaccc ccgcactctc
    17521 atgcgtccga agacggagca tgacgaccgg acttccggtg cagtgccacc ttcgtacccc
    17581 cgcggggccg ttcgcgaggg ttgcaaaggg ttgcaaccat gtggggcata tcgccgcgcg
    17641 ccaaccgccg ggcgggcacg atgaattcag gacacccggg ctcggcagtc ggcgagcccg
    17701 gtgtcgacgg caggaggatc cggtgcacac caccatgctg gacgtggccc gtctggccgc
    17761 catggacgcc caggaggccg cccggctcct gacgcgcgtg cgcgcggcca cgctggcggg
    17821 cagggattcg aaggtcgccc cgcgcacgga gatcggggag tcctggcggc gggcgctgaa
    17881 cagtgggctc gatcccgacg gggacaaccg cgcggggctg ctgtcgctgg ccgaggtcga
    17941 acggcgcaga cggcgctcgc cgctggcgga ggtcctgccg gtgctgcggg acgcgctggt
    18001 gtcggtcgcg gacgcggccc agcacatcat ggtcgtctcg gacgccgagg ggcggctgct
    18061 gtggcgcgag ggccaccctt ccgtcctgaa gctggccgac gccctcggct tcgaggtcgg
    18121 tgccgactgg agcgaggcgg ccgtcggcac caacggcgtg ggcaccccct tggtcaccgg
    18181 ccggccggtg caggtgtatt cggccgagca cttcgtggcc tcccaccaca cctggacctg
    18241 tgcgggcgcg cccgtcgtgg acccgcgcga cgggcggctg ctcggcgtgg tcgacatcag
    18301 cggcccgctc ggcaccatgc atccggccac gctgtccttc gtgacctcgg tggcccggct
    18361 cgccgccgcc gagctgcgca accggcactt cgccgccctg gagcggctgc gcacggcggc
    18421 cgccccggtg ctgtgccggg tcggcggtcg ggcgctggcc gtcgacgaca acggctgggt
    18481 ggccgcggtc accggcatgc cgcccctcga ccggctcgcc ctgcccaagg tgccgcgcgc
    18541 gggccgggtg tggttgccct cgctcggcat gtgcgccgtc gagccgctgc cgggcggccg
    18601 gctggtgcgg gtgtgcgagg aggcagacgg ctcggacacc gcgacggccc ggcgggtcgt
    18661 gctcgacgtc agccggcccc ggcgctgctc ggtgacggtg tcgggcgaca cggggagctg
    18721 gacgcaggag ctcagccccc gccacgccga gctcctgttc gtcctcgcgc tgaaccggga
    18781 gggcctcagc gccgcccagc tcgcgcggga catcttcgcg gacccgacgc gcacggtgac
    18841 ggtacgggcc gagatgtcac ggctgcgccg ccacctcgcc gaggtgctcg cccaccgccc
    18901 ctaccgcttc agcgaggacg tacgggtgga ggtggtccgg ccggaccacg cggcggacct
    18961 gcttccccat tcgctgtccc cgtcgatcgc ccgggcccgg ggcggccacc agcgacccgc
    19021 gtggcaagcg tccgaggccc cgtgattgcc tggcgtgcat gagtatcacc gtgaccacct
    19081 ggtccctgga acagaccgcc gtcaccgatc tgcgcccggc cgccgaaccg gccgacggct
    19141 tcacgatcgt gcgggccgag gtgccctcgc cggagttcag ccgcttcctc tatacggcgg
    19201 tcggtgggga catcaagtgg gtcgaccggc tcggcatgac gtacgaggcg tgggagcggg
    19261 aactgaacag gccgggcacc gagacgtggg tggcctacga ccgggggacg cccgcgggct
    19321 atgtcgagct ccaggcccag cccggcggct cggtcgagat cgtctacttc ggtctgatcc
    19381 ccgccttccg cggtcggcgc atgggcggcc ccctgctgac gtacgggacc cggcgcgcct
    19441 gggacctggc cgagcgctgg ccggaactgc ccgcgaccga gcgggtgtgg ctgcacacct
    19501 gctccctgga cggcgagcac gccatggaca actatgtgcg gcgcggcttc aaactgttcg
    19561 ccaccgtcga ggaacaggtg gcggaggtcg ccgcgcccgg cccctggccg ggggcgttct
    19621 gacggcgcgg agcgtccgcc tccgccagtg acccgcagca caccgtccca cgatgcggga
    19681 cagctaagtc cacattttgg atagtggtgg actgggtcca aagtcccgtg acacgcttcc
    19741 gtcatgtctg gaactggaat tgccttggtg agtcggcggc acgtcgacct cggccgcatg
    19801 tccagcgcca tctgtccggc ccgctgacgc tccagcaccg ccgcgattcc ccctgttaac
    19861 ggttcccctc tgtcctgacc gcgcaccgcc gcgccgaagc gcgagtgtgc aggtcagagc
    19921 cgcccccttg cagtcccgaa ggacatacgc catggccgcc agcccagaaa accctgcccc
    19981 cacgacgccc cgccgcaagc cgggccgcca ccgtggtgaa ggccagtggg ccgtcggcca
    20041 cttcacgccg ctcaacggga acgagcaggt gaagaaggac gacgacggtc tcaatgtgcg
    20101 gacacgcatt gagacgatct actccaagcg cggcttcgac tcgatcgacc ccagcgatct
    20161 gcgcggccgg atgcgctggt ggggtctcta cacccagcgg cgccagggca tcgacggcgg
    20221 caagacggcg atcctggagc cggaggagct ggacgacgag tacttcatgc tgcgcgtccg
    20281 catcgacggc ggccggctca ccaccgagca gctgcgggtg atcggcgaga tctcgcagga
    20341 gttcgcgcgc ggcaccgccg acctcaccga ccgccagaac atccagtacc actggatccg
    20401 catcgaggac gtcccggaga tctggaaccg gctcgaagcg gtcggcctgt ccaccaccga
    20461 ggcctgcggc gacaccccgc gcaccatcct cggctcgccg gtcgccggga tcgccgcgga
    20521 cgagatcatc gacggcaccc ccgccatcga cgagatccac cgccgcttca tcggcaacc
//
