LOCUS       NZ_CP032698            22832 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1037581
            Orig. end                         :: 1060413
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22832
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="7"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22832
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22832
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12832](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12832)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     CDS             complement(274..432)
                     /gene="allorf_1037855_1038013"
                     /locus_tag="allorf_1037855_1038013"
                     /protein_id="allorf_1037855_1038013"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRSRRAWVQGSSLMLVTPLSRARVGRKVRKSRSGARCSSRPAAPT
                     SSSPVRP"
     CDS_motif       complement(400..432)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRSRRAWVQGS"
                     /locus_tag="allorf_1037855_1038013_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(274..399)
                     /prepeptide="core"
                     /locus_tag="allorf_1037855_1038013_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="4165.9"
                     /monoisotopic_mass="4163.4"
                     /core_sequence="SLMLVTPLSRARVGRKVRKSRSGARCSSRPAAPTSSSPVRP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRSRRAWVQGS"
                     /leader_location="[399:432](-)"
                     /alternative_weights="4183.9"
                     /alternative_weights="4201.9"
                     /alternative_weights="4219.9"
                     /alternative_weights="4237.9"
                     /alternative_weights="4256.0"
                     /alternative_weights="4274.0"
                     /alternative_weights="4292.0"
                     /alternative_weights="4310.0"
                     /alternative_weights="4328.0"
                     /alternative_weights="4346.1"
     gene            471..3239
                     /locus_tag="DWB77_RS04700"
                     /old_locus_tag="DWB77_00942"
     CDS             471..3239
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="DWB77_RS04700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00942"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_162952427.1"
                     /transl_table=11
                     /translation="MSGEARGEMRGSGGVGGWDSLVASGTASLERQGRLAVHGPWGSGK
                     STLVDELVARAAGPALRVHAREEDQHLPCSGLAQLWGGALLTGSVPPEDPAARLGLRAA
                     TARALADHPGSLLVVEDAQWLDPVSADVLGHCARALPSDLLPMVVAERSVRRPARAAGL
                     LGGYPPLLSMEPASLDETAAVLDALGLPARWATAVHRYSGGHRALLAACCDDLADASPD
                     PGALTGRLPPVRLRRAEDLAAAWLDTAPPEVLATLRTAALTTRPDADLLRRAGCPDADD
                     HVRYALRAGLLVPQLPPDQRDLADSSVRFAAGALARVAAVTMDARTRRRTHHALAEVVR
                     DPIRAAWHRAMAQDGTDPATARDTAGAAVAARAAGESGLAAELMWCAARLTPVDQGEVR
                     LERLTEAAHDAAVAGACDLAHRAAQDIAEAHGTPSQQVSAVLAVIDACGQDLTGAEPLF
                     TAARRAAGQDPALLAAIELRAAVQANVAAGDSARALRHARSAAALAHTGADVVLEAAAL
                     TMAARMERVLGRLESAPATLAAALALAVAPPRMGIRNSPEYLAARHAVFDGRFTEARAA
                     LMDLLPVALGSGGAEDLAEIWRSLAEVDSALGACSRALRWADSALSITATADLSPGPAW
                     YTAALVHSHGGSFDRALGYATRALGASRAEHDALHTTRSLWILGAVHLHGGHVDRAAAT
                     LAEVAESEERPGADDPAILRWQADAVEAFAGAGQTARAHALLDRMQHTVKPHASHALLR
                     AALTRSRAVCVHQDGDSEGAVELLDDTARAFATLGTPVEEGRTLLVRGRVERRRRRSAA
                     ARTAWEQARTIFEAAEAHPWIALADEHLSRLTGLPPGPGGSASRAPGTSLTAHELRLAG
                     LICSGCTNQEAAQQMFVSRKTVESTLSRIYRKLGVRNRTQLTAALPPPTGA"
     gene            complement(3304..3627)
                     /locus_tag="DWB77_RS04705"
                     /old_locus_tag="DWB77_00943"
     CDS             complement(3304..3627)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS04705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_00943"
                     /product="hypothetical protein"
                     /protein_id="WP_120720022.1"
                     /transl_table=11
                     /translation="MTYEQPLPEPDPEAQGPTEAERAGREAVRRQAQGMGHREAVHAFR
                     RLADAPDSPSEDEADAADDRGDGGRRLAELAEWERIVEQLSLHAGTYDVETDPYVQGER
                     AAH"
     gene            complement(3787..4557)
                     /locus_tag="DWB77_RS04710"
                     /old_locus_tag="DWB77_00944"
     CDS             complement(3787..4557)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134361.1"
                     /locus_tag="DWB77_RS04710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00944"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_120720023.1"
                     /transl_table=11
                     /translation="MARHVGGRGWYGKVAGAAVGVTMLATGASVWTAQAGSADTPSPKE
                     SASAPASDLEPVADTIAHTSEAGPRGINITIDDGPDPKWTPQVLDLLRQYGVKATFCMV
                     GTQAQAHPDLVKKVVAAGHRLCDHTVSHNTAMDKASETYQSQQILDAERMITKASGGVR
                     PMYYRAPGGAFTPYSRQLAASRGMRPLGWNVDSKDFERPGTDAIVATVQREVHGGPTLL
                     FHDAGGDRAQTVAALRRLLPWLKKQGYTFGFPTH"
     CDS             complement(4648..4869)
                     /gene="allorf_1042229_1042450"
                     /locus_tag="allorf_1042229_1042450"
                     /protein_id="allorf_1042229_1042450"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRQHFVRRRHGPRSPGPGGVGRPAAESVASGSEADPVIGSDAGSS
                     TRPAHNSVDSGRSSQRLSSSSNDCVRDW"
     CDS_motif       complement(4750..4869)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRQHFVRRRHGPRSPGPGGVGRPAAESVASGSEADPVIGS"
                     /locus_tag="allorf_1042229_1042450_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4648..4749)
                     /prepeptide="core"
                     /locus_tag="allorf_1042229_1042450_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.90"
                     /molecular_weight="3324.4"
                     /monoisotopic_mass="3322.6"
                     /core_sequence="DAGSSTRPAHNSVDSGRSSQRLSSSSNDCVRDW"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRQHFVRRRHGPRSPGPGGVGRPAAESVASGSEADPVIGS"
                     /leader_location="[4749:4869](-)"
                     /alternative_weights="3342.4"
                     /alternative_weights="3360.4"
                     /alternative_weights="3378.4"
                     /alternative_weights="3396.5"
                     /alternative_weights="3414.5"
                     /alternative_weights="3432.5"
                     /alternative_weights="3450.5"
                     /alternative_weights="3468.5"
                     /alternative_weights="3486.6"
                     /alternative_weights="3504.6"
     misc_feature    complement(4889..4905)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    complement(4892..4908)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            4972..6333
                     /locus_tag="DWB77_RS04715"
                     /old_locus_tag="DWB77_00945"
     CDS             4972..6333
                     /GO_function="GO:0004806 - triglyceride lipase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016042 - lipid catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530516.1"
                     /locus_tag="DWB77_RS04715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00945"
                     /product="lipase family protein"
                     /protein_id="WP_120720024.1"
                     /transl_table=11
                     /translation="MPTTAVRHLATAVATALAFTAAPAATAVAAPSAPSSPSVATKAAH
                     DDPFYAYDGSEPLSSFAPGTVLKTRTLPYHLAGIPTPVKAVQLLFRTTDAQGRPSVGVT
                     SVVRSPGGDGTKAVSYQSAYDSLNPADGPSRAIAGNVSLGGLLPTAESLVLVPFLLQGY
                     DVVVPDTEGQSADFAAGPEYGTTTLDSIRAVGRSPETGMSPNTRFGLIGYSGGAIATQW
                     AATLAPSYAPDVNRNLVGFTEGGLLVDPAHNLKYVDGSVVWAGVIPMALIGTSRSFGID
                     LKPYMNSYGLEVYKKLENGSIVNALAQYPGLTWKKLAKPEYANPNSVPEFIEAVNKLNL
                     GSAATPTVPGFIAQGNGGVLEGTFSNLPGIGTGDGVMVAGDVRTLARQYCATGNTSIKY
                     QQYGVLSHVGAIVPWAPAALSWLNDRFAGKTAPSDCGRIPAGNSLAPEKPTSAS"
     gene            complement(6531..7472)
                     /locus_tag="DWB77_RS04720"
                     /old_locus_tag="DWB77_00946"
     CDS             complement(6531..7472)
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090732.1"
                     /locus_tag="DWB77_RS04720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00946"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_120720025.1"
                     /transl_table=11
                     /translation="MRFLSAKSVPAGAGSPGRGVGEGCDAAARTLLKGLDALGGLKQLD
                     KVTGPLQKAVRALPLGPYRAVLQGRPIGHPLHPVLVQVPIGAWTSAAVLDLLPGGGRHA
                     RLLVGMGVVSALPATWAGWVDWAEQPERQLRTGVVHAASNGVAIGLYAGSWVVRGRGRP
                     LLGRVLGFAGLTLASVGGMIGGHLAYRQGVGANKTEPVDHLVEPGWHPVGRAAEFTEGQ
                     GVRRMLGEVPLLVVREADGAFRVLVDRCSHMAGPLSQGKVADGCVECPWHGSVFRLADG
                     ENVGGPATAPQPTFETRLTDNGVLEVRLPGAV"
     gene            7639..8241
                     /locus_tag="DWB77_RS04725"
                     /old_locus_tag="DWB77_00947"
     CDS             7639..8241
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265558.1"
                     /locus_tag="DWB77_RS04725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00947"
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="WP_120720026.1"
                     /transl_table=11
                     /translation="MSDLFIKICGLRAARDVDTCVEAGADAIGFVFAPSARTVDAATAR
                     RLAGRVPDHVLTVGVFRGQPLTEVRRLTEECGIGAVQLHGDEGPEYYEALRGPGRTLIR
                     ATSQPRVVPGELGEDLLLLDAPEPGSGKPWNWASPDFAAPTGRWLLAGGLHPGNVRHAI
                     ETTGAWGVDVSSGVESERGVKSGDLIRAFIEAARPRR"
     gene            complement(8333..9073)
                     /locus_tag="DWB77_RS04730"
                     /old_locus_tag="DWB77_00948"
     CDS             complement(8333..9073)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015338.4"
                     /locus_tag="DWB77_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00948"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_162952428.1"
                     /transl_table=11
                     /translation="MRAATLNIWGRGSAWRRRLPLIRAELVRLAPDVVGLQEVWRRGSR
                     CQAEQIADDLGYHVTYARAVARAGFSQGNALLTRVPVERYEVLALPTPGVEPRSVLCAE
                     VGSTTVLVTHLTWEWEHAHIRHQQVRFLAELADRHADRGVVISADLNAAPDTEEIRWLT
                     SRMRDAWADGGQGPGHTFTPDNAFARRAREPARRIDFVLTNGRLRAARAELAFTAPGRT
                     RRRPLWPSDHFGVVCDLTPAPPPS"
     misc_feature    complement(9045..9059)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 21.75"
                     /tool="antismash"
     gene            complement(9159..9782)
                     /locus_tag="DWB77_RS04735"
                     /old_locus_tag="DWB77_00949"
     CDS             complement(9159..9782)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF041196.1"
                     /locus_tag="DWB77_RS04735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00949"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_162952429.1"
                     /transl_table=11
                     /translation="MKQERAVQTRHTLIRAAARVFEERGYAQASLREISAVAGMSVGAL
                     HFHFASKAHLFEEVEAAGRASLHWAARQAERPGMDALQKLTAISNALAVQIRTDVVSRA
                     GFHLNSQSEPGSPGRLQDEWRACVGHLLKEAAHQDLLDADLDVTDLADAYFAATLGMEL
                     LSRKAHRPLSCHALAGLWQLTLPSRKSTPRHTPTPETARLPSRR"
     misc_feature    complement(9690..9692)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12832)
                     /locus_tag="DWB77_RS04740"
                     /old_locus_tag="DWB77_00950"
     CDS             complement(10001..12832)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024964.4"
                     /locus_tag="DWB77_RS04740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00950"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_216826830.1"
                     /sec_met_domain="DUF4135 (E-value: 3.8e-67, bitscore:
                     225.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8e-40, bitscore:
                     135.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASGSMPGTSDETEHFARPVGTIARPWRDELARRLDALGSLGRHE
                     RDVLLDAGHQALLRSLHAKLSRLFLIELHALRLADGGEQDASAARDSTATWDAFIERAC
                     EEGYLAQLADRYPTLNYRVAEVARLSVAAVAGFAERLGADRALLSPLLGAPAGELRAVE
                     FGAGDSHRGGLTVTRADFACGTVMYKPRPSEADVALGALLDDLFADLPEAPAPDQRIRV
                     PRTLPRDGYGWAEFIGHRYCADEAELGVFYRNIGHWLAVLRFTGGTDMHAENMIAAGPV
                     PVIVDAETLFDAPAPFPPSGRGDAVDVAATAIRRTVLRTGLLPVRGTGFALGGVDISGI
                     GALPGQQPLIPHPVIADGGTGAARFEVGLVAMPVAGNHPAATPVLATYWDRVLAGFREM
                     TAHLRRPGVDPYRLLRRFEGVRARRILRPTQAYVDIGRMLWHPASLYDEAAAVERARDI
                     LRRNADVLPGAPTDRAPIDAEIADLLLGDVPMCGFTVDTSAVRATVEDWRTADLAFEES
                     VIQDALVGAYLNERSLPPRVQATTREPHARDRERRRRALAAQMVRRLCDGAVRGQDGTV
                     TWISPVFTPAGWSIRVLPADLYTGQGGVALTLAEYASEVRAGRADEVPGVAEVFEGALR
                     VLLATEDKTPTPSAGAFSGAASQVWTWLALHRVLGEDRLLERAAERASLLTEGPLIDDD
                     IEVDLLNGAAGAIVPLLDLAAATGKADWLDAAAHVGRRLTGLAVIDAAGARWPTRLNPE
                     GIGGFAHGATGIGWALARLALTDAGTGAERRDWSRLAAQAFAYQESLYRPGDGNWLDVR
                     VGAEEDFFTSWCHGSAGVGIGMLDLHRRTGDPGHLDMARRAATACAAEGFGWSHTLCHG
                     DLGLWEFLTSMGHGDRAQLDGEILTGLEQRGPVGGLAREAFSPSLMSGLAGVLHTLLRM
                     HPAADLPNPLLLD"
     gene            complement(12967..13167)
                     /locus_tag="DWB77_RS04745"
                     /old_locus_tag="DWB77_00951"
     CDS             complement(12967..13167)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240677.1"
                     /locus_tag="DWB77_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00951"
                     /product="DUF6229 family protein"
                     /protein_id="WP_120720029.1"
                     /transl_table=11
                     /translation="MSQNGVFASTVLHAWLSGAESAYGQLNPAGPLYVGGTAAEAALTD
                     PSDSLYGFCSSPSGSRGSWCC"
     CDS_motif       complement(13096..13167)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSQNGVFASTVLHAWLSGAESAYG"
                     /locus_tag="DWB77_RS04745_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12967..13095)
                     /prepeptide="core"
                     /locus_tag="DWB77_RS04745_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="4032.4"
                     /monoisotopic_mass="4029.9"
                     /core_sequence="QLNPAGPLYVGGTAAEAALTDPSDSLYGFCSSPSGSRGSWCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSQNGVFASTVLHAWLSGAESAYG"
                     /leader_location="[13095:13167](-)"
                     /alternative_weights="4050.4"
                     /alternative_weights="4068.4"
                     /alternative_weights="4086.4"
                     /alternative_weights="4104.4"
                     /alternative_weights="4122.5"
                     /alternative_weights="4140.5"
     misc_feature    13253..13267
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    complement(13255..13266)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            13462..13854
                     /locus_tag="DWB77_RS04750"
                     /old_locus_tag="DWB77_00952"
     CDS             13462..13854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981066.1"
                     /locus_tag="DWB77_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00952"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_120720030.1"
                     /transl_table=11
                     /translation="MTRTGIEAALNDLLFNRDITLDEAADRHFTPDYRQRTDDEWADRG
                     AFLDHIGHLRGIIAGGHVDVHEELYDGDKYADRHTCHVTKVDGTTVAMEVYVFADLAAD
                     GRFRRIEETTLMLQGTDADRDLGSAR"
     gene            complement(13894..14613)
                     /locus_tag="DWB77_RS04755"
                     /old_locus_tag="DWB77_00953"
     CDS             complement(13894..14613)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035883.1"
                     /locus_tag="DWB77_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00953"
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="WP_120720031.1"
                     /transl_table=11
                     /translation="MSRISARGFAVASATAVTTVGAVVGVAGGGAAVASNDNVEATASD
                     STLLADIPAGQQAQVQTASLAQQADAQSAQASAAAKKAAEEAARLKAAQDARAKKDAAV
                     KGKADKDKADKADKEAKARDLETQSASRASSRSTFQVQSSYSVSDVQAIARQIIPADQF
                     QCFSNIVNKESSWNYTASNGAAYGLVQALPGSKMSSAGSDWQTNPATQIKWGLNYMNGR
                     YGSPCGAWSFWLTHQSY"
     gene            complement(15040..15642)
                     /locus_tag="DWB77_RS04760"
                     /old_locus_tag="DWB77_00954"
     CDS             complement(15040..15642)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551542.1"
                     /locus_tag="DWB77_RS04760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00954"
                     /product="DUF2867 domain-containing protein"
                     /protein_id="WP_120720032.1"
                     /transl_table=11
                     /translation="MRLLRTAHSELPWRIHELTRDFTVEDVWALPTPGGPDDLKWLVGQ
                     LAEGIRGGMGGDTPLSRLLFAVRWKLGALLGWDKSDAGVGSRVPSLRDRLPADLLEGLR
                     GPDLGANKFSSLYQRQDEWAAEMANRTVHAVLHIGWVPDGSGGYHGQMAVLVKPNGRFG
                     GLYMAAIKPFRYLGVYPALIRGIGREWQASRPERSSH"
     misc_feature    complement(15666..15684)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            15740..16297
                     /locus_tag="DWB77_RS04765"
                     /old_locus_tag="DWB77_00955"
     CDS             15740..16297
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735298.1"
                     /locus_tag="DWB77_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00955"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_120720033.1"
                     /transl_table=11
                     /translation="MGATRTPRDKWIEEGLRALVAGGPDAVRIEALAQALGVSKGGFYG
                     YFRNRGALLTEMLDTWEYEVAESVIQQVERDGGDARARLTRLFDVADAVEGPARGAAAD
                     IAIRDWARRDPEVAERLRRVDNRRMDYLRSLFSSFCSDEDEVEVRCLLTVSVRIGNHFN
                     AADNGKRSRADVMELIRRRLLE"
     gene            16421..16924
                     /locus_tag="DWB77_RS04770"
                     /old_locus_tag="DWB77_00956"
     CDS             16421..16924
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-164). E-value:
                     1.5e-26. Score: 85.5. Matches aSDomain:
                     nrpspksdomains_DWB77_RS04770_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979872.1"
                     /locus_tag="DWB77_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00956"
                     /product="SRPBCC family protein"
                     /protein_id="WP_120720034.1"
                     /transl_table=11
                     /translation="MARVVTVSHSIVVSVSPEVVYRAVSCPADMGRWSPENLGTTDGAA
                     REPAELGSEFVGRNKRGMFRWVTRCTVTAADPGRRFAFRVHAIGLSRPRLRGPIATWEY
                     RFEPVEGGTRITETWVDDRKAWPDSVANVFDRLATSGSTFAAFQSRNIKATLRNLKREL
                     EGSR"
     aSDomain        16433..16912
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS04770_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.50E-26"
                     /label="DWB77_RS04770_Polyketide_cyc2.1"
                     /locus_tag="DWB77_RS04770"
                     /protein_end="164"
                     /protein_start="4"
                     /score="85.5"
                     /tool="antismash"
                     /translation="VTVSHSIVVSVSPEVVYRAVSCPADMGRWSPENLGTTDGAAREPA
                     ELGSEFVGRNKRGMFRWVTRCTVTAADPGRRFAFRVHAIGLSRPRLRGPIATWEYRFEP
                     VEGGTRITETWVDDRKAWPDSVANVFDRLATSGSTFAAFQSRNIKATLRNLKRELE"
     gene            complement(16942..17352)
                     /locus_tag="DWB77_RS04775"
                     /old_locus_tag="DWB77_00957"
     CDS             complement(16942..17352)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_00957"
                     /product="hypothetical protein"
                     /protein_id="WP_162952430.1"
                     /transl_table=11
                     /translation="MTAETERSGDESADVHEARLAIDAYMRRTSARTQQEGAAGPLADQ
                     GAEAGGGERPGQDDDRVDDRVAECVAREAWDAVQDATPPPPDPEAGPSEKTTQSPERAE
                     LHRRAVAIARGLQALGYHLDETLLPGPDMAAG"
     gene            complement(17402..18520)
                     /locus_tag="DWB77_RS04780"
                     /old_locus_tag="DWB77_00958"
     CDS             complement(17402..18520)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014178991.1"
                     /locus_tag="DWB77_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00958"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_120720036.1"
                     /transl_table=11
                     /translation="MTTPVTIIGAGLGGLTLARVLHLHGIPATVYEAESSPTARSQGGM
                     FDIHDYNGQLAVEAAELMDEFRGLILEGRQAMRVLDPDGTVLHEIADDGTGGRPEVLRG
                     ELRQIFLDSLPAGTVQWGRKVSGTRALGEGRHQVTFADGTTVDTALLVGADGAWSRVRP
                     LVSAVTPEYIGKSVVETYLFEADTRHPRAAKTVGGGAMIALRPDREMFAHREKGDTLHA
                     YLGLYEPQEWFDAIDFADATAALAAIAREFDGWAPELTALITEADTAPILRPLYALPID
                     HRWDRVPGVTLLGDAAHLSVPNGEGANLAMLDGADLGLALASHPGDIEAALTAYEQAMF
                     PRSAEAATFGGPDSHGPDAEVNGGPPLSQSTK"
     gene            complement(18723..19178)
                     /locus_tag="DWB77_RS04785"
                     /old_locus_tag="DWB77_00959"
     CDS             complement(18723..19178)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_00959"
                     /product="hypothetical protein"
                     /protein_id="WP_120720037.1"
                     /transl_table=11
                     /translation="MAPPRHELDRAWELATSVTSDVPEWRPEPQPLDVYAPCGSTAWAC
                     GTRRQILWRLPLTARDRRPVSLKLVTADQWRGAVSQLAAEVDPDRGGATVTVPHVPRGT
                     YWIQVSRGSRLLATSRPFAIGPAQGPRPTYGYRRARTTPPRASGYRA"
     gene            complement(19275..19757)
                     /locus_tag="DWB77_RS04790"
                     /old_locus_tag="DWB77_00960"
     CDS             complement(19275..19757)
                     /GO_function="GO:0043169 - cation binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013936.4"
                     /locus_tag="DWB77_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00960"
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_120720038.1"
                     /transl_table=11
                     /translation="MPTSDAIVMLREGHKEIRRLIRSYRLGEDPEAVDQLLRALAVYTY
                     IECEGMYPRVSVLAPETEPTILALREEHHIAEVLAAELHEMRPEDISYDPKARLLMDIV
                     ERHMDTEDNALFPHVRAAVGRRELREIGAWMSTLSERAPLRPHRPSRQQIWDAVAA"
     gene            complement(19935..20501)
                     /locus_tag="DWB77_RS04795"
                     /old_locus_tag="DWB77_00961"
     CDS             complement(19935..20501)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128967.1"
                     /locus_tag="DWB77_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00961"
                     /product="isochorismatase family protein"
                     /protein_id="WP_120720039.1"
                     /transl_table=11
                     /translation="MTTLVNRPNTAVLVIDVQNGVVAQAHDRDGVVAKIATLIDKARAA
                     DVDVIWIQHNDEELVTGTEPWEYVPELVRRESEPLVQKAYGDSFEETELESVLAARGIG
                     RLLVAGAQTDACIRSTLHGAITRGYDATLVGDAHTTDDLSRFGAPSPAQVIAHTNLYWR
                     SHSAPGRTAGTVDTADVDFAPHSRA"
     gene            complement(20498..21445)
                     /locus_tag="DWB77_RS04800"
                     /old_locus_tag="DWB77_00962"
     CDS             complement(20498..21445)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547532.1"
                     /locus_tag="DWB77_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00962"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_120720040.1"
                     /transl_table=11
                     /translation="MLERLELEAFLTLAEELHFGRTAERLHLTTGRISQSIKKLERHIG
                     TPLFERTSRYVRLTPAGRQLHEDLLPPYEQLRAGLHRAVDAAQGIQSVLRVGFVGAASG
                     QLMVHAAQLYAERHPGHRAQPRELQIADSYPRLRDGDVDLLIVSLPHQEAGTAVGPVLY
                     SERRMLAVSREHPLAGRESVSLEDLTAVKLLQARSVPTHWRTARTPLYTPAGHPVEAGP
                     EFETFQEALALIGADQGAFIVGAQAMHYYARSDVAYLPFSDAPPLEWAPVWLTARAAPR
                     IHDFNRAALDAATRIHLAAAREPQPSAATPREVP"
     misc_feature    21460..21473
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.91"
                     /tool="antismash"
     misc_feature    21478..21494
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.15"
                     /tool="antismash"
     CDS             complement(21491..21658)
                     /gene="allorf_1059072_1059239"
                     /locus_tag="allorf_1059072_1059239"
                     /protein_id="allorf_1059072_1059239"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MMIPIWKNSSRGEGGRAERSPSPAGGGGHGHASATAPRGRTAAGQ
                     DCNAAQASTR"
     CDS_motif       complement(21584..21658)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MMIPIWKNSSRGEGGRAERSPSPAG"
                     /locus_tag="allorf_1059072_1059239_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21491..21583)
                     /prepeptide="core"
                     /locus_tag="allorf_1059072_1059239_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="2744.9"
                     /monoisotopic_mass="2743.3"
                     /core_sequence="GGGHGHASATAPRGRTAAGQDCNAAQASTR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MMIPIWKNSSRGEGGRAERSPSPAG"
                     /leader_location="[21583:21658](-)"
                     /alternative_weights="2762.9"
                     /alternative_weights="2780.9"
                     /alternative_weights="2798.9"
                     /alternative_weights="2816.9"
     misc_feature    21664..21678
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.07"
                     /tool="antismash"
ORIGIN
        1 cggaaccgac ggtcccggcg cggggtcgga agcggcggcc cgggcgggca gcgcggccag
       61 accggccaag gtgagcacgg ccagggccgt ggtgacgatg cgcggatttc tcgcaggacg
      121 catgggggga gcacactcct tcggtgctgg tggagaccgg agcgggcgcg gaagagacgg
      181 ggatcgcgcc gcggaagtac gagcgccggc cactgggatg ggcccaactt caccgcccac
      241 aggggcactt ggccatccgg cagctccctt gactcacggc cggacgggac tgctggaggt
      301 gggagcggcc ggtcgggatg agcaccgtgc ccccgaccgg gattttcgga ccttacgccc
      361 aactcgggcg cgcgataagg gagttacgag catcagggaa ctcccttgca cccacgcccg
      421 acgcgatcgc acccttggcg atgctcgaag gggggcctag cgtgcgggag gtgagcggag
      481 aagcacgcgg cgagatgcgg ggaagcggag gcgtcggagg gtgggactcc ctcgtcgcct
      541 cgggcaccgc gtcgctggag cggcagggac ggctcgccgt ccacggcccc tggggctcgg
      601 gcaagtcgac cctggtggac gaactggtgg cccgggccgc cggccccgcg ctccgcgtcc
      661 acgcccggga agaggaccag cacctgccct gctcgggcct cgcccaactc tggggcggag
      721 cgctcctcac cggctccgta ccgccggaag atcccgccgc acggctggga ctgcgcgccg
      781 cgacggcgcg ggcgttggcg gaccaccccg ggtcgctgct ggtcgtggag gacgcccagt
      841 ggctcgaccc ggtcagcgcc gacgtgttgg ggcattgcgc acgggccctg ccgtccgatc
      901 tgctcccgat ggtggtggcc gagcgttccg tgcggcggcc cgcccgggcg gcggggctgc
      961 tgggcggcta tccgcccctg ctctccatgg agcccgcgag cctcgacgag accgcggcgg
     1021 ttctcgacgc tctgggcctg ccggcccgct gggccacggc cgtccaccgg tacagcggcg
     1081 gccaccgggc cctgctggcc gcctgttgtg acgacctggc cgacgcctcc ccggacccgg
     1141 gcgccctgac cggccggctg cctccggtgc ggctgcgccg ggccgaggac ctggccgccg
     1201 cctggctgga cacggcaccc cccgaggttc tcgccacgct tcgcacggcg gccctgacca
     1261 cccgccccga tgccgatctg ctgcggcggg ccggctgccc cgacgccgac gaccatgtgc
     1321 ggtacgcgct gcgagccgga ctgctggtcc cccaactccc accggatcag cgggacttgg
     1381 ccgactccag cgtacggttc gcggccgggg cactggcccg cgtcgccgcg gtcaccatgg
     1441 acgcccgcac ccgacgccgt acccatcacg ccctcgcgga agtcgtccgc gatccgatcc
     1501 gggcggcctg gcaccgggcc atggcccagg acggcacgga cccggccacg gcgcgggaca
     1561 ctgcgggcgc ggccgtcgcg gcgcgcgcgg cgggcgagag cggactcgcc gccgaactca
     1621 tgtggtgtgc ggcccgcctc acgccggtcg accagggcga agtgcggctg gagcggctca
     1681 ccgaagccgc gcacgacgcg gcggtggcgg gcgcctgcga cctggcgcac cgggcggccc
     1741 aggacatcgc cgaggctcac ggaacgcctt cccagcaggt cagcgccgtg ttggcggtga
     1801 tcgacgcctg cggtcaggat ctgaccgggg cggagccgct cttcacggcg gcccgcaggg
     1861 ctgcggggca ggaccccgcc ctgctggccg ccattgaact gcgggccgcc gtccaggcca
     1921 atgtcgcggc gggcgactcc gcgcgcgccc tgcggcacgc gcgctcggcc gccgcactgg
     1981 cgcacaccgg agcggacgtg gtcctggagg ccgccgccct cacgatggcg gcccgcatgg
     2041 aacgcgtcct ggggcgcctg gagtcggccc ccgccacctt ggccgcggcc ctcgcgctgg
     2101 ccgtcgcgcc gccgcgcatg gggatccgta acagccccga atacctggct gcccgccacg
     2161 ccgtgttcga cggccggttc accgaggcac gggcggccct gatggatctg ctgccggtgg
     2221 cgctgggcag cgggggcgcc gaggacctcg cggagatatg gcgcagcctg gccgaggtcg
     2281 actccgcgct cggagcgtgt tcacgcgccc tgcggtgggc ggacagcgcc ctgtcgatca
     2341 ccgcgaccgc ggatctgtca ccgggccccg cgtggtacac ggccgcgctg gtccacagcc
     2401 acggaggctc cttcgaccgg gcgctggggt acgcgacccg ggcgctcggc gcctcccgcg
     2461 cggagcacga cgcgctgcac accacgcgca gcctgtggat cctgggcgcc gtccacctgc
     2521 acggcgggca cgtcgaccgg gcggccgcga cgctcgccga ggtcgccgag tcggaggaac
     2581 gcccgggcgc ggacgacccg gccattttgc gctggcaggc cgacgccgtc gaagccttcg
     2641 ccggcgcggg gcagacggct cgcgcgcacg ccctgctcga ccgcatgcag cacacggtca
     2701 agccgcacgc ctcccacgcc ctgctgcggg ccgcactgac ccgttcgcgc gccgtgtgtg
     2761 tgcaccagga cggagacagc gagggcgccg tcgagctcct cgacgacacc gcgcgcgcct
     2821 tcgcgacgct cggcacgccc gtcgaagagg ggcgcaccct gctcgttcgc ggccgggtgg
     2881 aacgacgccg gcgtcggtcc gcagccgccc gcaccgcctg ggagcaggcc cggacgatct
     2941 tcgaggccgc cgaggcccac ccctggatcg ccctcgccga cgagcatctg agccggctca
     3001 cgggcttgcc gcccggtccg ggcggtagcg cttcgcgggc gcccggcacg agcctgacgg
     3061 cccatgaact gcgtctcgcg ggactgatct gctcgggctg taccaatcag gaagccgccc
     3121 agcagatgtt cgtctcccgc aagacggtgg agtcgaccct cagccgcatc taccgcaagc
     3181 tcggcgtccg caaccgcacc caactcaccg ccgccctgcc gccgcccacc ggcgcctgac
     3241 gggtcgcacg gacggttccg gccgtgcaca aaagcgttgt ggatgagctg agttgacggt
     3301 acgtcagtgt gccgcgcgct ccccctggac ataggggtcc gtctcgacgt cgtaggtgcc
     3361 cgcgtgcagg gagagctgct ccacgatccg ctcccactcg gccagttcgg ccagccgccg
     3421 accgccgtcc ccgcggtcgt ccgcggcgtc cgcctcgtcc tcggaggggc tgtccggcgc
     3481 gtcggcgagg cggcggaacg cgtgaaccgc ctcgcggtgt cccatcccct gcgcctgccg
     3541 gcgcacggcc tcgcgcccgg cccgctcggc ctccgtgggg ccctgcgcct cggggtcggg
     3601 ctcgggcagc ggctgctcgt acgtcatgtg ctggcctgct ctctgctggg tttcggggtc
     3661 ctggtacgga caggaccgtt ctgctgctct ccggtcaacg caccgaaccg tacgcggagt
     3721 tccactcccc ccacggacgg gtgcacagcc cggagcgtgc ccgaccttgc gacggccaca
     3781 cgggtctcag tgcgtcggga atccgaaggt gtatccctgc ttcttcagcc agggcagcag
     3841 acgccgcagc gccgcgacgg tctgagcgcg gtcaccgccc gcgtcgtgga agaggagcgt
     3901 cggtccgccg tgcacctcgc gctgcacggt ggcgacgatc gcgtccgtac ccggacgctc
     3961 gaagtccttg ctgtccacgt tccagccgag cggccgcatg ccccgggaag cggcgagctg
     4021 acggctgtag ggggtgaagg ccccgccggg tgcccggtag tacatcgggc gtacgccccc
     4081 ggaggccttg gtgatcatgc gttcggcgtc gagtatctgc tgcgactggt aggtctcgga
     4141 cgccttgtcc atggcggtgt tgtgcgacac cgtgtggtca cagagccggt gcccggccgc
     4201 caccaccttc ttgacgaggt ccgggtgggc ctgggcctgc gtccccacca tgcagaacgt
     4261 ggccttcact ccgtactgcc tcagcaggtc gaggacttgg ggggtccact tggggtcggg
     4321 cccgtcgtcg atggtgatgt tgatgccgcg cggcccggcc tccgaggtat gggcgatggt
     4381 gtccgcgacg ggctcgaggt cactggcggg cgcggacgcg gactccttgg gcgacggcgt
     4441 gtccgcggaa cccgcctgcg cggtccacac cgaggcaccc gtggcgagca tcgtcacccc
     4501 taccgccgcg cctgccacct tgccgtacca accccgccca ccgacgtgcc gtgccatgcc
     4561 cgccccttcc acgcagtccc tcgacgatct ccggtcgcct tgcgaccacc cgtcaggacg
     4621 acgcgttcac atcaggggct gcctctgtta ccaatcacgg acacagtcgt tggagctcga
     4681 agacaacctc tgcgaactac gtccggaatc aaccgaatta tgggccggtc gggttgatga
     4741 tcccgcgtca cttccgatga ccggatccgc ctccgagccc gacgcgaccg actccgccgc
     4801 agggcgtccc acgcctccgg gccctggtga gcggggtccg tgccgtcgcc tcacaaagtg
     4861 ttgccgcatc cctgggcaac ggacttacct cttggtaact tacaacgcta ttaccccaag
     4921 taacacgtgc gtcgcccatc cccgagatcc acctagtgag ccgagggatc catgcccacc
     4981 accgccgtac gacacctggc gaccgcggtc gccaccgcgc tggccttcac cgccgctccg
     5041 gcggcgaccg ccgtggccgc gccgtccgcc ccctcctccc cgtccgtggc gaccaaggcc
     5101 gcgcacgacg atccgttcta cgcctacgac ggcagcgaac cgctgtcctc gttcgcgccc
     5161 ggcaccgtac tcaagacgcg aaccctcccc taccacctcg ccggtatccc cacgccggtc
     5221 aaggcggtcc agctgctctt ccgcaccacc gacgcccagg gccgcccctc cgtcggcgtg
     5281 acctcggtgg tgcgcagccc cggcggcgac ggcaccaagg cggtgtccta ccagtccgcg
     5341 tacgactccc tcaatcccgc ggacggcccg tccagggcga tcgcgggcaa cgtcagcctc
     5401 gggggcctgc tgcccaccgc cgaatcgctc gtcctggtgc cgttcctgct ccagggctac
     5461 gacgtcgtcg tcccggacac cgaggggcag agcgccgact tcgcggccgg ccccgagtac
     5521 ggcaccacta cgctggactc catccgggcg gtcggcagat cccccgagac cggcatgagc
     5581 cccaacaccc gcttcgggct catcggttac tccggcggcg cgatcgcgac tcagtgggcg
     5641 gccactctcg cgccgagcta cgcgccggac gtcaaccgca acctggtggg cttcaccgag
     5701 ggagggctgc tggtcgaccc ggcgcacaac ctcaagtacg tggacggcag cgtggtgtgg
     5761 gccggtgtca ttcccatggc gctcatcggc acctcacgct cgttcggcat cgacctgaag
     5821 ccctatatga acagctacgg gctcgaggtg tacaagaagc tcgaaaacgg ctccatcgtc
     5881 aatgccctgg cccaataccc gggtctgacg tggaagaagt tggcgaagcc ggagtacgcc
     5941 aacccgaact ccgtgcccga gttcatcgag gccgtcaaca agctgaacct cggctcggcc
     6001 gccaccccga ccgtccccgg gttcatcgcc cagggcaacg gtggcgtact ggaggggacc
     6061 ttcagcaacc ttccgggcat cgggaccggt gacggggtca tggtcgcggg cgatgtgcgc
     6121 acgctggcca ggcagtactg cgccaccggc aacacgtcga tcaagtacca gcagtacggc
     6181 gtgctcagcc atgtcggggc catcgtcccc tgggctccgg ccgcactgag ctggctcaac
     6241 gaccgcttcg cggggaagac cgcgccctcc gactgcggcc ggatcccggc ggggaactcg
     6301 ctcgcgccgg agaagccgac gtccgcctcc tgacggcccg cgcttccccc gacggcccgc
     6361 gcttcccccg gctccccggg gtggagacgg ctcgtgacgc catcgcgcgt cacgagcccc
     6421 cgcgccgggg cggccggacc ccggctcacg ccggggtccg agtccggtcc ggacagggcc
     6481 ggttcggtca gggccgcttc agtcccgttc ggtcccgttg cgggaaagac tcagaccgcg
     6541 ccgggaagcc tgacttccag gacgccgttg tcggtcagac gggtttcgaa ggtgggctgg
     6601 ggtgccgtgg ccgggccgcc cacgttctcg ccgtcggcca ggcggaagac gctcccgtgc
     6661 cacgggcact cgacgcaacc gtcggcgacc ttgccctggg acaggggtcc cgccatgtgg
     6721 ctgcaccggt cgaccagtac gcggaacgcg ccgtccgcct cccgcaccac gagcagcgga
     6781 acctcgccca gcatccgccg gaccccctgc ccttcggtga actccgcggc cctgcccacc
     6841 gggtgccagc ccggctccac caggtggtcg accggctccg tcttgttggc ccccactccc
     6901 tggcggtagg cgagatgacc gccgatcatt ccgccgacgc tcgccagggt cagcccggcg
     6961 aacccgagca cgcgaccgag caacggcctg ccccggcccc gtacgaccca ggagccggcg
     7021 tacagaccga tggccacgcc gttcgacgcc gcgtgcacga ctccggtacg cagctggcgt
     7081 tcgggctgct ccgcccagtc cacccatccc gcccaggtgg cgggcagggc cgagacgaca
     7141 cccatgccca ccaggaggcg cgcgtggcgc ccgccgccgg gcagcaggtc cagcaccgcc
     7201 gcggaggtcc acgccccgat cggcacctgc accagcacgg ggtgcaacgg atgcccgatc
     7261 ggccgaccct ggaggacggc acggtagggc cccagcggca gggcgcggac ggccttctgg
     7321 aggggaccgg tgaccttgtc cagttgcttg agcccgccca gcgcgtcgag ccccttgagc
     7381 agggtccggg ccgcggcatc acacccttcc cccacgcctc gtcccgggga gcccgccccg
     7441 gccggcaccg acttcgctga caggaatcgc atgggatccg gttaacccct gcggcccgac
     7501 cccaaacggc ccgggcgccg cttgtacccg tacacgagcc gcgtcggcgc accggccccc
     7561 gcccggtggt gggttcaccg aggagctggt acgcggcggc cggcccagag gcgggccgac
     7621 ctttgattga ctcggggcat gagcgatctc ttcatcaaga tctgcggcct gcgggccgcg
     7681 cgggacgtcg acacctgcgt cgaggccgga gcggacgcga tcggcttcgt cttcgcgccc
     7741 agcgcgcgaa cggtggacgc cgccacggcg cggcggctgg cgggccgggt gccggaccac
     7801 gtcctgaccg taggcgtctt tcgcggccag ccgctgaccg aggtgcgcag gctcacggag
     7861 gagtgcggca tcggcgcggt tcagctgcac ggggacgaag ggccggagta ctacgaggcg
     7921 ctgcggggcc cgggccgtac gctgatccga gccacatccc aaccccgcgt cgttcctggg
     7981 gagttgggcg aggacctgct gctcctggac gcgccggagc ccggctcggg caagccgtgg
     8041 aactgggcct cccccgactt cgccgcaccg accggccgct ggctcctcgc gggcggtctg
     8101 caccccggca acgtccggca cgcgatcgag accaccgggg cctggggagt ggacgtctcc
     8161 agtggcgtgg agagcgaacg cggcgtcaaa tcgggcgact tgatccgtgc gttcatcgag
     8221 gcggcccgcc cacgccgata gccgcaccgg gacacgacct gccgcccggc ccgcgagcac
     8281 cggcatgagg tgccgcaact gccgtgcccg ccaagcgtgt tgacccgtac gtctacgacg
     8341 ggggcggcgc cggcgtgagg tcgcagacca cgccgaagtg gtcggagggc cacagtggcc
     8401 gacggcgtgt gcggccgggc gcggtgaacg ccaactccgc gcgtgccgct cggagtcggc
     8461 cgttcgtgag gacgaaatcg atgcgccgcg ccggttcacg ggccctgcgc gcgaatgcgt
     8521 tgtcgggcgt gaacgtgtgg cccgggccct ggcccccgtc cgcccacgcg tcccgcatcc
     8581 ggctggtcag ccaccgtatc tcctcggtgt ccggggccgc gttcaggtcg gccgagatca
     8641 ccaccccccg gtcggcgtgc cggtccgcga gctccgcgag gaaccggacc tgttggtgtc
     8701 tgatgtgcgc gtgctcccac tcccaggtca gatgggtgac gagcacggtc gtcgagccca
     8761 cctcggcgca cagcacggac cggggctcga cgcccggcgt cggcagcgca agcacctcgt
     8821 accgctcgac gggcacccgg gtgagcagcg cgttgccctg gctgaacccc gcgcgcgcca
     8881 cggcccgggc atacgtcacg tggtacccca ggtcgtcggc gatctgctcc gcctggcatc
     8941 tcgacccccg ccgccacacc tcttgcagcc cgacgacatc aggggcgagg cggacgagct
     9001 cggccctgat caggggcagt cgccgacgcc aggccgagcc ccggccccag atgttgagcg
     9061 tggcagcacg caccgtatcc acctccccac cgtacccagc gggccccccg tgccccgagg
     9121 tctccgggac gcccacccgt cccgtgcggt gttcaagatc agcggcggct gggcaaccgg
     9181 gcggtctcgg gtgtcggggt gtgtcgtggg gtggacttgc gggagggcag cgtcagttgc
     9241 cacaagccgg ccaaggcgtg acaggacaag ggacggtggg ctttgcggct gaggagttcc
     9301 atgccgagcg tggcggcgaa gtacgcgtcg gcgaggtcgg tgacgtcgag gtccgcgtcg
     9361 agcaggtcct ggtgggccgc ctccttcagg aggtggccca cacaggcgcg ccactcgtcc
     9421 tggagccgtc ccggcgagcc cggttcgctc tggctgttga ggtggaatcc ggccctggac
     9481 acgacgtcgg tacgtatctg cacggccagg gcgttcgaga tcgcggtcag cttctgcaag
     9541 gcgtccatgc ccggtcgttc ggcctgtcgg gccgcccagt gcaggctcgc ccgccccgcg
     9601 gcctccacct cttcgaagag gtgcgccttg gacgcgaagt ggaagtgcag cgcccccaca
     9661 ctcattccgg cgacggcact gatctcccgt aaggacgcct gggcatagcc ccgttcctcg
     9721 aagacccgtg ctgcggcacg aatcagcgtg tggcgggtct ggacggcacg ctcctgcttc
     9781 acgtacgact ccctcggctc tgtcacaccg cgggtgggag cgcgctcggg tcgccctcac
     9841 cctttctccc ggacagcgtt cttggccccg ttcgtgtcac accaccggac gggctccgct
     9901 tcatctggga gggtgccgaa gatattccgg gccgcacggg gccgccgacg ggccgagtgg
     9961 aggcacccgt cgtgccggag gtccgcgaca cggggaggcg tcagtcgagg aggagggggt
    10021 tgggaaggtc ggcggcgggg tgcatgcgaa ggagggtgtg gaggactccg gcgaggccgg
    10081 acatgaggct cggcgagaac gcctcgcggg ccaggccgcc gaccgggcca cgctgttcga
    10141 ggccggtgag gatctcaccg tccagttggg cgcggtcgcc gtgtcccatg gaggtcagga
    10201 actcccagag ccccaggtcg ccgtggcaca gggtgtggct ccagccgaag ccttcggcgg
    10261 cgcaggcggt ggccgcgcgt cgggccatgt cgaggtggcc ggggtcaccg gtgcggcggt
    10321 ggaggtccag catcccgatg ccgacgccgg cgctgccgtg gcaccagctg gtgaagaagt
    10381 cctcctccgc gccgacgcgg acgtcgagcc agttgccgtc cccgggacgg tagagcgact
    10441 cctggtaggc gaaggcctgt gcggcgaggc ggctccagtc gcggcgttcg gccccggtgc
    10501 ccgcgtccgt gagggcgagc cgggccagcg cccagccgat gccggtggcg ccgtgcgcga
    10561 agcccccgat gccctcgggg ttgagacgag tgggccaacg cgcgcccgcc gcgtcgatca
    10621 cggcaaggcc ggttagccgc cgcccgacgt gtgccgccgc gtccagccag tcggccttcc
    10681 cggtcgcggc ggccaggtcg agcagcggga cgatcgcccc ggccgcgccg ttgaggaggt
    10741 ccacctcgat gtcgtcgtcg atcagcgggc cttcggtgag cagcgaggcc cgctcggcgg
    10801 cccgctccag cagccggtcc tcgcccagga cgcggtgcag cgccagccac gtccacacct
    10861 gtgaggcggc gccgctgaac gccccggccg acggggtcgg cgtcttgtcc tcggtggcga
    10921 gcagcaccct gagtgcgccc tcgaacacct cggccacgcc cggcacttcg tcggcccggc
    10981 ccgcccgcac ctcgctcgcg tactcggcca gcgtgagcgc cactccgccc tgcccggtgt
    11041 agagatcggc gggcagcacc ctgatcgacc acccggcggg ggtgaagacg gggctgatcc
    11101 aggtgaccgt gccgtcctgc ccacgcaccg ccccgtcgca caaccgccgt accatctggg
    11161 cggccagcgc gcggcgccgg cgctcgcggt cgcgggcgtg cggttcgcgc gtggtggcct
    11221 gtacccgcgg gggcagcgag cgctcgttca ggtacgcgcc gaccagcgcg tcctggatca
    11281 ccgactcctc gaaggcgagg tcggcggtac gccagtcctc gacggtggcg cgcacggcgg
    11341 aggtgtccac ggtgaagccg cacatcggca cgtcgccgag cagcagatcc gcgatctcgg
    11401 cgtcgatggg tgcgcggtcg gtcggcgcgc cgggcaacac gtcggcgttg cggcgcagga
    11461 tgtcgcgggc gcgctcgaca gccgccgcct cgtcgtacag cgaggccggg tgccacagca
    11521 tccggccgat gtcgacatag gcctgggtgg gccgcaggat ccgccgggcc cggacgccct
    11581 cgaagcggcg cagcagccgg tacgggtcga ctccggggcg ccgcaggtgc gcggtcattt
    11641 cacggaaccc ggccagcacc cggtcccagt acgtggcgag gacgggtgtg gcggccggat
    11701 ggttgcccgc gacgggcatg gccaccaggc ccacctcgaa gcgcgccgcg ccggtaccgc
    11761 cgtcggcgat caccgggtgc gggatcagcg gctgttgacc gggcagcgcg ccgatcccgg
    11821 agatgtcgac gccgcctagg gcgaagccgg tgccgcgtac gggcagcagt ccggtgcgca
    11881 gcacggtgcg gcggatggcc gtggcggcca cgtccaccgc gtcgccccgg ccgctgggcg
    11941 ggaagggcgc cggggcgtcg aagagcgtct cggcatccac gatcaccggt acgggccccg
    12001 cggcgatcat gttctcggcg tgcatgtccg tgccgccggt gaaccgcagc acggccagcc
    12061 agtgcccgat gttccggtag aacacgccga gttcggcctc gtcggcgcag tagcggtggc
    12121 cgatgaactc ggcccagccg tagccgtcac gaggcagtgt cctcggcaca cgtatgcgct
    12181 ggtccggcgc cggggcctcg gggaggtcgg cgaacaggtc gtccaggagc gcgccgaggg
    12241 ccacgtcggc ctccgacggc ctgggcttgt acatcacggt cccgcaggcg aagtcggccc
    12301 gggtgacggt gagtccgccg cgatgggagt cgccggcccc gaactcgacg gcccgcaact
    12361 cgccggcggg cgcgccgagc agcgggctca gcagcgcccg gtccgcgccg aggcgttccg
    12421 cgaaacccgc cacggccgcc accgagagcc gcgccacctc cgcgacgcgg tagttcaacg
    12481 tcgggtaccg gtcggcgagc tgggcgaggt agccctcctc gcaggcccgc tcgatgaacg
    12541 cgtcccacgt cgccgtggag tcccgggcgg cggaggcatc ctgctcacca ccgtcggcca
    12601 ggcgcagggc gtgcagttcg atcaggaaca ggcgggacag cttcgcgtgc agcgaccgga
    12661 gcagcgcctg gtggccggcg tccaggagta cgtcccgttc gtgccgcccc agcgatccca
    12721 gcgcatcgag ccgccgggcc agttcgtccc gccaggggcg ggcgatggtg cctacgggcc
    12781 gggcgaagtg ttcggtctcg tccgacgtcc ccggcatgga tccgctcgcc atcaaccgtc
    12841 cccgttccac cgcgagttcg cgccctgcgg ggcgccctga aggagcccgc gacgcgggcg
    12901 tcggtcatgc gacgggcccc tcgcgggacg tcgttccacg aagggccctt tggtcggctg
    12961 cgacgatcag cagcaccaac tcccgcgcga cccgctcggg ctggaacaga agccgtagag
    13021 ggaatcgctc gggtcggtga gcgccgcctc ggcggcggtc ccccctacat agagcggacc
    13081 ggccgggttg agctggccgt acgcgctctc ggcgcccgac agccaggcgt ggagcaccgt
    13141 gcttgcgaaa acaccgttct gcgacatcgg cggcctccga acagagggat ggggcgaaca
    13201 gcccaggcct gagtatggcg atgcctgaac acccgtcaga cgcacaatcc ggccaaattc
    13261 gttttcagcc gaagaccgcc cagcggacgg gtgggcgagc gcgcctgcat cggtcgcacg
    13321 ccagacagcc atcacgcagc cgtcacgcac gcatgaatag cgtgcgcaac gcacgcatcc
    13381 ggtgctaccg taaaagcgaa gcgtgcgcaa cgcacgcatc gctttcgctt ctcacgccca
    13441 tcgaccaccg aaggactcgc catgacgcgc accggcatcg aagccgccct caacgacctg
    13501 ctgttcaacc gtgacatcac gctcgatgag gcggccgacc gtcacttcac gcccgactac
    13561 cgccagcgca cggacgacga gtgggccgac cgcggcgcgt tcctcgacca catcggccac
    13621 ctccgcggca tcatcgccgg cggtcacgtg gacgtacacg aggagctgta cgacggcgac
    13681 aagtacgccg accggcacac ctgccacgtc accaaggtcg acggcaccac cgtcgccatg
    13741 gaggtctacg tcttcgccga cctcgccgca gacggccgct ttcgccgcat cgaggaaacc
    13801 accctcatgc tccagggcac cgacgccgac cgcgatctcg gcagcgcccg ctgaccatcc
    13861 ggctcccccg gggccggacg cgccgctcag ccgtcagtac gactggtgcg tcagccagaa
    13921 cgaccaggcg ccgcaggggc ttccatagcg cccgttcatg tagttgaggc cccacttgat
    13981 ctgcgtggcc gggttggtct gccagtcgga gcccgcggag ctcatcttgg aaccgggcag
    14041 cgcctgaacg agcccgtagg cggcgccgtt ggaggccgtg tagttccagc tggactcttt
    14101 gttcacgatg ttgctgaagc actggaactg atcggcgggg atgatctggc gggcgatcgc
    14161 ctggacgtcg gagaccgagt aggagctctg cacctggaag gtgcttcggc tcgacgcacg
    14221 gctggcggac tgggtctcca ggtcgcgagc cttcgcttcc ttgtccgcct tgtccgcctt
    14281 gtccttgtcg gccttgccct tgacggcggc gtccttcttg gccctggcgt cctgggcggc
    14341 cttgaggcgc gccgcctctt cggccgcctt cttcgccgcg gcactggcct gcgccgactg
    14401 ggcgtccgcc tgctgggcca gggacgcggt ctgcacctgg gcctgctggc cggcgggtat
    14461 gtcggcgagc agcgtcgaat cggaggccgt ggcctcgacg ttgtcgttcg aagcgaccgc
    14521 agcgccgccc ccggcgacgc cgacgacggc gcccacagtg gtgaccgcgg tggcggacgc
    14581 caccgcgaat ccccgtgccg atatccgact cacacgcttt ccttccagcg gcacccgcac
    14641 ggctgacctc gcggacgcaa tcattgccgt ggcccgcccc tcccctccgt caggtcacgg
    14701 aagggattgc ccgtcggaca actcccttac ggaaggcgtc gcttggtgct cgggtgacac
    14761 acggctcagt tacggagttg agagcgtacc tcgatacggg agttgcggga gagccgtgtg
    14821 tggggccttc tggaagccag actctgctcg aagtcgacgc cgccgggcaa ttcttcacag
    14881 cgtgtcaaac ctcacacctg ccaggttccc gactgtcctt cccacccctt ccgcaggggg
    14941 actacgcgag atatggtgcg cgccccagca caccgcccca acacaccgca gcaccaatgc
    15001 cgcgacccag cgcggcgact caccggcatc cgcccgcgat cagtgcgagc tgcgctcggg
    15061 gcggctcgcc tgccattcgc ggccgatgcc gcggatcagt gccgggtaga cgccgagata
    15121 ccggaacggc ttgatcgcgg ccatgtagag accgccgaac cggccgttcg gctttaccag
    15181 gaccgccatt tggccgtggt agccgccgct gccgtccggc acccagccga tgtgcagcac
    15241 cgcgtggacc gttcggttgg ccatctcggc cgcccattcg tcctgccgct gatagagcga
    15301 gctgaacttg ttcgcgccga ggtcggggcc ccggagcccc tcgagcaggt cggccgggag
    15361 acggtcccgc aaggagggga cccgggagcc gacgccggcg tcggacttgt cccagccgag
    15421 cagagccccg agcttccagc ggacggcgaa gagcagccgg gagagcgggg tgtccccgcc
    15481 catcccccct cgaatcccct cggccaactg acccaccagc cacttcaggt cgtcgggccc
    15541 gccgggcgtg ggcagcgccc acacgtcctc aacggtgaag tcgcgggtca actcgtggat
    15601 ccgccacggc agttcgctgt gtgcggtacg gagaagtcgc atgagcagtc ccccacatct
    15661 atacggctgc gtatagatcg agcatagccc catctatacg cccccgtata ctcgttggcg
    15721 acgtgaggag acacacgaca tgggcgcgac tcgcacgcca cgcgacaaat ggatcgagga
    15781 aggcctgcgc gccctggtcg cgggcggtcc cgacgccgtc cgcatcgagg cgctcgcgca
    15841 ggcgctcggg gtcagcaaag gcggcttcta cggctatttt cgcaatcggg gagctctgct
    15901 caccgagatg ctcgacacct gggagtacga ggtcgccgag agcgtgatcc agcaggtcga
    15961 gcgggacgga ggagacgcga gggccaggct gacgaggctg ttcgacgtgg ccgacgccgt
    16021 cgagggcccc gcacgcggcg ccgcggcgga catcgcgatc cgcgactggg cgcgccgcga
    16081 cccggaggtg gccgagcgcc tgcgccgcgt cgacaaccgc cgcatggact atctgcggtc
    16141 cctcttctcc tcgttctgct ccgacgagga cgaggtcgag gtccgctgcc tgctgaccgt
    16201 ctccgtgcgc atcggtaacc acttcaacgc ggcagacaac ggcaagcgca gccgagcgga
    16261 cgtcatggaa ctcatcaggc ggcggctcct ggagtagccg cgcagccgtc agtgagagcg
    16321 gggaccggga gtcgtggccc gcgacgtgcc aggatcagta ccggccagta gcttcgtggg
    16381 gccgaagagg tccgaagagg tccggagaga aggagtggtc atggcgcggg tcgtcacagt
    16441 cagccacagc atcgtcgtca gcgtgtcgcc cgaggtcgtc taccgggcgg tgagctgccc
    16501 ggccgacatg ggccgctgga gcccggagaa cctcggcacc acggatgggg cggcgaggga
    16561 accggccgag ctcgggtcgg agttcgtcgg gcgcaacaag cgggggatgt tccgctgggt
    16621 gaccaggtgc acggtcacgg cggccgatcc ggggcgccgg ttcgcgttcc gcgtccatgc
    16681 catcgggctg agccggcctc ggctgcgcgg cccgatcgcc acctgggagt accgcttcga
    16741 gccggtcgaa ggaggcacgc gcatcaccga gacctgggtc gacgaccgca aggcctggcc
    16801 cgactccgtg gccaacgtct tcgaccgcct cgccacctcg ggcagcacct tcgccgcctt
    16861 ccagtcccgc aacatcaagg cgacgctgcg gaatctcaag cgggagctgg aaggcagcag
    16921 gtaaggccgg cggcggactc gtcaccccgc ggccatgtcc gggccgggca gcagggtctc
    16981 gtccaagtgg tagccgagtg cctgcaagcc gcgcgcgatg gcgacggccc tgcggtgcag
    17041 ttccgcgcgc tccggagact gggtggtctt ctcggagggg cccgcctcgg ggtcgggcgg
    17101 gggcggagtg gcgtcctgca ccgcgtccca cgcctcgcgc gcgacgcact ccgccacccg
    17161 gtcgtccacc cggtcgtcgt cctgcccagg ccgctcgcct ccgcccgcct ccgcgccttg
    17221 atccgcgagc gggccggccg cgccttcctg ctgcgtacgt gccgatgtcc ggcgcatgta
    17281 ggcgtcgatc gcgaggcggg cctcgtggac gtcggccgac tcatctccgc tgcgttccgt
    17341 ctctgccgtc atgcaacgca acgtaaacgc cgcctcgccc gagggcctcg acgccacgcg
    17401 ctcatttggt ggactggctg agcgggggcc ccccgttgac ctccgcgtcg ggcccgtggg
    17461 agtcgggtcc cccgaaggtg gcggcctccg cgctgcgggg gaacatggcc tgctcgtacg
    17521 cggtgagcgc ggcctcgatg tcgccggggt gcgaggcgag cgcgaggccg aggtcggctc
    17581 cgtcgagcat ggccaggttg gcgccctcgc cgttcgggac cgacaggtgg gcggcgtcgc
    17641 cgagcagggt caccccgggc accctgtccc accggtggtc gatcggcagg gcgtacaggg
    17701 ggcgcaggat cggtgcggtg tcggcttcgg tgatcagggc ggtgagttcc ggcgcccagc
    17761 cgtcgaattc ccgcgcgatg gctgcgaggg ccgcggtggc atcggcgaag tcgatcgcgt
    17821 cgaaccattc ctgcggctcg tacagaccca ggtaggcgtg cagcgtgtcg cccttctccc
    17881 ggtgggcgaa catctcccgg tccggcctga gcgcgatcat cgcaccgcca ccgaccgtct
    17941 tcgcggcacg cggatgccgg gtgtcggcct cgaacagata ggtctcgacg accgatttgc
    18001 cgatgtactc gggtgtgacg gcggagacca ggggcctgac ccgtgaccag gcgccgtccg
    18061 cgccgaccag cagagcggtg tcgacagtgg tgccatcggc gaacgtcact tggtggcgtc
    18121 cttcgccgag ggcacgcgtg ccgctgacct tgcgccccca ctggacggtg ccggcgggca
    18181 gtgagtcgag gaagatctgt cgcagctcgc cacgcagcac ctcggggcgg ccgcccgtgc
    18241 cgtcgtcggc gatctcgtgg aggacggttc cgtccgggtc gaggacccgc atcgcctgac
    18301 ggccctccag gatgaggccg cgaaactcat ccatcaactc ggctgcctcg acggcgagtt
    18361 ggccgttgta gtcgtggatg tcgaacatgc cgccctgcga gcgggccgtc ggtgaggatt
    18421 ccgcttcata gacggtcgcg ggtatcccat ggaggtgcag aacgcgggcg agcgtgaggc
    18481 cgccgaggcc ggcgccgatg atcgtgacgg gagtggtcat gcggggtgtc cccctcgggt
    18541 cgggcacccc ggccgggcgg ccccggcagg tcacgccggg ggcgccgttc cagtgggccg
    18601 ggacggtgcg agctggtggg cggcgccgtt gcttcccggc gccgtcagct ccaatgtccc
    18661 ggcggccacc gacaaaccac cgacaattca ctacccctta ccgacagtcg cccgaccgcg
    18721 gttcaggccc ggtagcccga ggctcggggc ggggtcgtcc gtgcgcggcg gtagccgtag
    18781 gtcggccggg gtccttgggc ggggccgatc gcgaacgggc ggctggtggc gaggagtcgg
    18841 ctgccacggg agacctggat ccagtacgtg ccccggggga catggggcac ggtgacggtc
    18901 gcgccgccgc ggtccgggtc gacctcggcc gccaactgcg agaccgcgcc gcgccattgg
    18961 tcggcggtga ccagtttcag gctcaccgga cgccggtccc gcgccgtcag cgggagacgc
    19021 cacaggatct ggcgccgagt accgcaggcc cacgcggtgg agccgcaggg cgcatacacg
    19081 tccaggggct ggggttcggg gcgccactcg ggcacgtcac tcgtgacgct ggtggccaac
    19141 tcccaggccc ggtccagctc atgacgtggg ggtgccatgc tgctgctccc tcctcctggc
    19201 gggcgactgc gcacccggcc agaccgatgt ggcgcgtctt cgcgctcagg tcagtgcggt
    19261 ggggaggggg cgcctcaggc ggccaccgcg tcccagatct gctggcggct ggggcggtgc
    19321 gggcgcagcg gagcccgctc ggagagcgtg gacatccagg cgccgatctc cctcagctcc
    19381 ctccggccca cggcggcccg gacgtgcggg aacaacgcgt tgtcctcggt gtccatgtgc
    19441 cgctccacga tgtccatcag gaggcgggcc ttcgggtcgt aggaaatgtc ctcgggacgc
    19501 atctcgtgca gctcggccgc cagcacttcg gcgatgtggt gctcttcccg cagagccagg
    19561 atggtcggct cggtttcggg cgccaagacg gagacccgtg ggtacatgcc ctcgcattcg
    19621 atgtacgtgt acacggccag cgcacgcagg agctgatcca ccgcctcggg atcctctccg
    19681 aggcggtagg agcggatcaa ccgcctgatc tccttgtggc cttcccgcag catcacgatc
    19741 gcgtcgctgg tgggcatggg cagctccccg ggggctcagg actcacttcc gtaacaggcc
    19801 gatacccggc aaaacagacg cccacacgtc atgggcgcga gggctaccct ccgccatcgc
    19861 ctgggcacgg aaggtgcctg gcgggcgccc gtcaggacac cgctggccgt cgcggcgcgg
    19921 tgcgcgcccc cacctcaggc gcgggaatgt ggggcgaagt cgacgtccgc ggtgtcgacc
    19981 gtcccggccg tgcggccggg ggccgagtga gagcgccagt acagattggt gtgggcgatg
    20041 acctgggccg gcgacggcgc accgaaacgc gacaggtcgt ccgtcgtgtg ggcatcgccg
    20101 acgagcgtcg cgtcgtagcc gcgggtgatc gcgccgtgca gcgtcgagcg gatgcatgcg
    20161 tcggtctggg cgccggcgac caggaggcgg ccgatgccgc gcgcggccag caccgactcc
    20221 agttcggtct cctcgaagga gtcgccgtac gccttctgca ccagcggctc ggattcgcgc
    20281 cgcacgagct cgggcacgta ctcccacggc tcagtaccgg tgaccaactc ctcgtcgttg
    20341 tgctggatcc agatcacgtc cacgtcggcg gcgcgtgcct tgtcgatcag ggtggcgatc
    20401 ttcgcgacga caccgtcccg gtcgtgcgcc tgcgccacca cgccgttctg cacatcgatg
    20461 accagcacgg cggtgttcgg acggttgacg agcgtggtca tggcacttcc ctcggggttg
    20521 ctgctgatgg ctggggttcc ctcgccgcgg cgaggtggat acgggtggcg gcgtcgaggg
    20581 ccgcgcggtt gaagtcgtgg atgcggggcg cggcccgcgc ggtgagccag accggggccc
    20641 attcgagcgg tggggcgtcg ctgaagggga ggtaggcgac gtcggagcgc gcgtagtagt
    20701 gcatggcctg ggcgcccacg atgaacgcgc cctggtcggc tccgatgagc gccagcgcct
    20761 cttggaaggt ctcgaactcc gggccggctt cgacggggtg gcccgcgggc gtgtacaggg
    20821 gggtgcgcgc cgtacgccag tgggtgggga ccgatctggc ctggaggagc ttgaccgcgg
    20881 tgaggtcctc gagggagacc gattcccgcc ccgccagggg gtgttcgcgg gagacggcga
    20941 gcatgcggcg ctcggagtac agcacgggtc ccaccgccgt gccggcctct tggtggggca
    21001 gggacacgat gagcaggtcc acgtccccgt cgcgcagcct ggggtagctg tcggcgatct
    21061 gtagttccct gggctgggcc cggtggcccg gatgacgttc ggcgtacagc tgcgccgcgt
    21121 gcaccatgag ctgtcccgag gcggctccca cgaacccgac ccgcagcacg ctctggatgc
    21181 cctgcgccgc gtcgaccgcc cggtgcaggc cggccctcaa ctgctcgtac gggggcagga
    21241 ggtcctcgtg cagctgccgg cccgcggggg tcaggcggac gtaacggctc gtgcgctcga
    21301 acaggggcgt cccgatgtgc cgttccagct tcttgatgct ctggctgatc cggccggtgg
    21361 tcaggtgcag gcgttccgcg gtccggccga agtgcagttc ctcggccagg gtcaggaacg
    21421 cctccagctc cagccgttcg agcaccgctt ccccctcggt tgagcccgat taaacgatcg
    21481 ctgcactatc tcatcttgtt gacgcctgtg ccgcgttgca gtcttggccc gcggctgttc
    21541 gtccgcgcgg cgcggtcgcc gatgcgtgac catgaccacc acccccggca ggcgacgggc
    21601 ttcgctctgc cctaccgccc tcaccgcgag atgagttctt ccagatcgga atcatcatgt
    21661 ccttgctcga ttcgagaaaa gccgtcgccg aatccgtcga tgaaccagtg ccgctccgcc
    21721 gctggctggc cgtcgtcacg atggcggtcg gcactttcgc cctggtcacc gtggagtcgc
    21781 tgcccgtggg gctgctcccg ctcatcgggg gctcgctcca tgtctccgag gggacggccg
    21841 gtttgatggt gaccgtcccc ggcctggtgg cctccgccac ggcgcccctg ctgccggtgg
    21901 cgatccggcg cctggaccgc agggccgtcc tgatggggct catcgtcctg atggtggcgg
    21961 ccaacgcgct gtccgcgacg gcgcccacct tcgcggtcct gctcggctcg cggttcctca
    22021 tcggggtcag catcggcggg ttctgggccc tcgcggccgg gctggccgtc cggctggtcc
    22081 ccgagcgttt cgtcccccgt gccatctccg tcgtcttcgc gggtgcgacc gccgccaatg
    22141 tgctgggcgt cccggccgga acactgatcg gcggattcac cagctggcgg gtggcgttcg
    22201 tggcggtggc ggggctcggt ctcctcgtcc tggtggccct gctcgtcctg atgccgccca
    22261 tgccggccca gcaggcggtc caactgcgcg ctctgccaag ggaattgcgc aacccggtcg
    22321 tccgggccgg cgtgctcacc accttcctcc tggtcagcgg tcacttcgcc gccttcacct
    22381 tcatcagccc gctgctccag tcggtctccg gcatcgacgc gaccacggtg ggcccgctcc
    22441 tcctggcgtt cggcgccgcc ggtgtcctcg gcaacttcct cgccggcgcc gccgcggaac
    22501 gcgacatccg cgccaccatc gtgaccatca gcgttctcct cacggccgtc ctcgcactgt
    22561 tccccctcat cggccgcacc ccggtcagcg gggcggtcct gctcatcgga tgggggctgg
    22621 ccttcggcgg tgtgccggtc ggcgtgcaga cctggatcct caaggcggca cccgagtcca
    22681 ccgaggccgc caccgcgctc aacacctcgg tgttcaacct cgccatcgcg ctcggcgccc
    22741 tgttcggcgg catcgtcgcc gaccacatgg cgctcaccgg tgtcctgacg accggggccg
    22801 ttctcgccgt cctcacctcc ctggcgctgt gg
//
