LOCUS       NZ_CP032698            25411 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces hundungensis strain BH38 chromosome, complete genome.
ACCESSION   NZ_CP032698
VERSION     NZ_CP032698.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces hundungensis
  ORGANISM  Streptomyces hundungensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Relationship between Morphology and Antimicrobial Activity in
            Streptomyces
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8393044)
  AUTHORS   Kang,H.J. and Kim,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2018) Microbiology and Molecular biology, Chungnam
            National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea,
            Republic of
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: RS HGAP Assembly v. v3.0
            Sequencing Technology             :: PacBio RSII
            Assembly Date                     :: 2018-07-09
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Genome Representation             :: Full
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003627815.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:42:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,472
            CDSs (total)                      :: 7,378
            Genes (coding)                    :: 7,187
            CDSs (with protein)               :: 7,187
            Genes (RNA)                       :: 94
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 191
            CDSs (without protein)            :: 191
            Pseudo Genes (ambiguous residues) :: 0 of 191
            Pseudo Genes (frameshifted)       :: 103 of 191
            Pseudo Genes (incomplete)         :: 121 of 191
            Pseudo Genes (internal stop)      :: 14 of 191
            Pseudo Genes (multiple problems)  :: 42 of 191
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 700667
            Orig. end                         :: 726078
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032698.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25411
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="4"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25411
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25411
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15411](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15411
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(820..1413)
                     /locus_tag="DWB77_RS03185"
                     /old_locus_tag="DWB77_00632"
     CDS             complement(820..1413)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740578.1"
                     /locus_tag="DWB77_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00632"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_120719770.1"
                     /transl_table=11
                     /translation="MTNAPLGRSAAFKVLTTGYVGSTGPGVAATVSYVSDAGRHVIFDP
                     GMVASRDDILAPLAELGLAPEDITDVVLSHHHPDNTMNVGLFGRARVHDHKVEYLDDQW
                     TNRDAEGYELTPSLRLIRTPGHSPEDITLLAGTDEGVVAFAGDLWWHANGPADDPVAPD
                     REVLRASRLRVMATADLIVPGHGSPFHPTDTTPV"
     gene            1506..2465
                     /locus_tag="DWB77_RS03190"
                     /old_locus_tag="DWB77_00633"
     CDS             1506..2465
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265099.1"
                     /locus_tag="DWB77_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00633"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_120719771.1"
                     /transl_table=11
                     /translation="MPPFKTVAAYAPAGVGMLAVGIVSEVFGPHGAALPGFDFALCTDR
                     PGEVAADCGVPLSVRHGVDRLAEADLVIALPGAGFRTPPAPPVLDALRTAHARGAVVAA
                     HCVGTFALAAAGLLDQRRATTHWRFAELLAGRFPGVTVEADALYIDEGSIVTGAGAAAG
                     FDLCLHLLRREYGAAQANAIARDMVLPAHRDGGQAQYLATPVPEDGDDVRLAEVLAWAR
                     ENLHEPQSVAELAHRAMLSKRTFARRFTAATGTTPHAWLRHLRLSRAEELLETTDLAIE
                     EIARQVGYGSAAVLRDQFVRRRGVPPRSYRQAFTTAPR"
     gene            complement(2486..3160)
                     /locus_tag="DWB77_RS03195"
                     /old_locus_tag="DWB77_00634"
     CDS             complement(2486..3160)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180075.1"
                     /locus_tag="DWB77_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00634"
                     /product="restriction endonuclease"
                     /protein_id="WP_246033385.1"
                     /transl_table=11
                     /translation="MRKRTLRQVQGWSSIVGAVAVVWLAAHWSAVWPVLVTVLGAAVLG
                     CVAWVVWRAHRTAVSRDREWRAQEEAKARELSMAQVDALSWQEFETYIAELCRRDGCTK
                     VVVSGRSGDLGADVIGYLADGRKLVIQCKKYAPHRSVPSQDMQKFVGTARLEHGADVAL
                     FVATCRAFTKDAMGLALRQDIVAIHRDLLGAWVKGAPLETLIPLNGSGGGSGAGTRRRP
                     SA"
     misc_feature    complement(3227..3245)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.94"
                     /tool="antismash"
     gene            3567..4802
                     /locus_tag="DWB77_RS03200"
                     /old_locus_tag="DWB77_00635"
     CDS             3567..4802
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009320488.1"
                     /locus_tag="DWB77_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00635"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_120719773.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.1e-09, bitscore:
                     36.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.1e-08, bitscore:
                     32.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVAIAPSVTASDAGRIGLSRTHWSRVARETADDLATDAVAREQA
                     GKAPFDEVARLREAGLLTLLIPREFGGGGADWSTACGVLREISAADGAVGQLLACHYFL
                     SWSARLFAGPALAEEVERKSAAQQWCWGGGLGGHDLPLTLTRKGAGYVLNGRQNYATGV
                     LVADRIAVRAERADTGETFAVVVDATCLGVRIDDDADTFGQRLAAGGNVEFDAVPVATK
                     DILGSLSEDEDVLSPRTALASPIGRLLSAQLLLGMAEGMLAEAREYGRAAHSPWRPDWP
                     IGSLQDPHVLTTYGELTVLARSASALADQAVTGVQAGLARGEELSFDEYAEISVLVAMA
                     EAAASKAAQESTTRALDVIGSRSASARLGFDRFWRNTRAHTLYEPVAPRLRDVGDYFLN
                     GAHPAFTLPARP"
     gene            4906..5364
                     /locus_tag="DWB77_RS03205"
                     /old_locus_tag="DWB77_00636"
     CDS             4906..5364
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058273.1"
                     /locus_tag="DWB77_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00636"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_120719774.1"
                     /transl_table=11
                     /translation="MRISARADYAVRAALQLAASRDAAPLKAEAIAEAQSIPHKFLEGI
                     LNDMRRGGLVLSQRGVNGGYRLAKPAESISIADVIRVVDGPLVSVRGVRPPELSYTGPA
                     ASLLPLWIALRANVREILDGVSLADVASAQLPSPVSELADAPGAWTNP"
     gene            complement(5425..7290)
                     /locus_tag="DWB77_RS03210"
                     /old_locus_tag="DWB77_00637"
     CDS             complement(5425..7290)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153761.1"
                     /locus_tag="DWB77_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00637"
                     /product="aldo/keto reductase"
                     /protein_id="WP_120719775.1"
                     /transl_table=11
                     /translation="MHANEQARTPQSRTPRKGAGRAPAPESAIPPRLLALQGAAGNAAV
                     VQMLRGSGHAWSQDQHAPTDGCGEQQHGQAEAVAVQRRSAVHDVLRAPGRPLDDHTRTD
                     MEARLGADFTGVRIHDGPEAKASAAEVGARAYTSGDHVVLGDNGADKHTLAHELTHVIQ
                     QRQGPVTGTDRGDGLRVSDPSDTFERAAEANARRAMAGSAPLQRATVPDDGPRHQHSPV
                     IARMPADTHASEAAKPWLVFGVDGRSKEQLTSAVDAGYRRFDTAESYRNTELVSEVLSG
                     LPRDSYEILYKFDVRSGESTDVLRARLERVAALFHGRFDSLVIHNLDGDKRVLAQAWQV
                     LTELKGDRVAAQIGLGNVGETNAGLLAEFGGVDVVENSVESALLSETVQNAIKESGAHL
                     YYYDVIRTARQMELDITSPDDLNGLIYTMAGTFHRPDGTSNATMISSSGSPGTQAANLE
                     NFGGGPDHEDFTGDEQYGAMEKIDKWRKQQSAGQTNDTSFELRPELGTWLAGLCEGGGA
                     DALRTALVEAAQEKGQPVTQSFIEEWLVQRGPVTAEDLGSVRVPSRVGLKRRYIGMPLR
                     DTLAALFGVKNCDWKWSIELVQLLFSDVDTWDCALRFGAEGIVQE"
     gene            complement(7501..8157)
                     /locus_tag="DWB77_RS03215"
                     /old_locus_tag="DWB77_00638"
     CDS             complement(7501..8157)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963152.1"
                     /locus_tag="DWB77_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00638"
                     /product="cutinase family protein"
                     /protein_id="WP_120719776.1"
                     /transl_table=11
                     /translation="MRKGRIAAALAALLLTSGLSLAQGSPAQAVTAPCDGTYTIVVGGT
                     WSTWDNDRFVGNIQQHVGYASQVPSGPSVRQGVGELNRLVREQRAACPWQHVKMGGYSL
                     GAAVVHVWVSENWRTFDNVNAVLIADPKRQGGPGTNGSAAPFGGVIGPPLSGADRDFGN
                     VPVKSICYWDYICDESAGFWTYPGNHNNNYWPDFDMNHHADDSNEQWYNGAWYPW"
     misc_feature    complement(8128..8130)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8353..9132)
                     /locus_tag="DWB77_RS03220"
                     /old_locus_tag="DWB77_00639"
     CDS             complement(8353..9132)
                     /NRPS_PKS="Domain: Thioesterase (26-250). E-value: 1e-34.
                     Score: 112.9. Matches aSDomain:
                     nrpspksdomains_DWB77_RS03220_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="DWB77_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00639"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_120719777.1"
                     /sec_met_domain="Thioesterase (E-value: 1.9e-32, bitscore:
                     112.0, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5e-10, bitscore:
                     39.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDAPSGFAPHIRPFPTTASADGHPQLLFFPHSGSSAGSYRGLA
                     GRLADTARPACVQYPGRAERRSSPPFTDVHALADELAQAFAAWHEGGPVVLFGHSLGAV
                     VAYEVVRRTADQRRLVLVASGHPAPSRLGLPSIVPPGDGTEDPDQPLVDLLRSLGDDSG
                     LLDHPVLRSVFLPVIRGDLAAHGRYRPEPGGTVACPVVALMGNADPLTDPADVQAWEQH
                     TAATFRMHTFHGGHFFTNERAGEVADVLRALCARAAS"
     aSDomain        complement(8383..9054)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS03220_Thioesterase.1"
                     /evalue="1.00E-34"
                     /label="DWB77_RS03220_Thioesterase.1"
                     /locus_tag="DWB77_RS03220"
                     /protein_end="250"
                     /protein_start="26"
                     /score="112.9"
                     /tool="antismash"
                     /translation="QLLFFPHSGSSAGSYRGLAGRLADTARPACVQYPGRAERRSSPPF
                     TDVHALADELAQAFAAWHEGGPVVLFGHSLGAVVAYEVVRRTADQRRLVLVASGHPAPS
                     RLGLPSIVPPGDGTEDPDQPLVDLLRSLGDDSGLLDHPVLRSVFLPVIRGDLAAHGRYR
                     PEPGGTVACPVVALMGNADPLTDPADVQAWEQHTAATFRMHTFHGGHFFTNERAGEVAD
                     VL"
     CDS_motif       complement(8797..8859)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS03220_0001"
                     /evalue="5.30E-09"
                     /label="NRPS-te1"
                     /locus_tag="DWB77_RS03220"
                     /protein_end="112"
                     /protein_start="91"
                     /score="28.5"
                     /tool="antismash"
                     /translation="GPVVLFGHSLGAVVAYEVVRR"
     gene            complement(9122..9811)
                     /locus_tag="DWB77_RS03225"
                     /old_locus_tag="DWB77_00640"
     CDS             complement(9122..9811)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570252.1"
                     /locus_tag="DWB77_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00640"
                     /product="FCD domain-containing protein"
                     /protein_id="WP_120719778.1"
                     /transl_table=11
                     /translation="MPLGALRPTPLVEQATERLREQITQGEWSVGTKLPGENALAQILG
                     VGRSTVREALRALAGAGLVQPRQGAGVFVIATKPQEDWPTSLRRAAVTDVYEVRMLIEV
                     EAAQMAAQRRTDDDLVALDKALAHRRDAAEAGDAEFVDADIALHAAVVAAAHNPVLTGL
                     FAEFVPVLRQGLIDLVELLGLRSGDPNHGDDGHTLLVEAIARADAESAGRTLREELKRT
                     LERLHAI"
     misc_feature    9859..9877
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     gene            10001..11797
                     /gene="leuA"
                     /locus_tag="DWB77_RS03230"
                     /old_locus_tag="DWB77_00641"
     CDS             10001..11797
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019993757.1"
                     /locus_tag="DWB77_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00641"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_120719779.1"
                     /sec_met_domain="HMGL-like (E-value: 7.2e-65, bitscore:
                     217.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATSPTQAFATLRTPSGPVPEGAPAWNPQRPSAMPHERYRPAHDR
                     VALPLTDRTWPSRRLERAPLWVPVDLRDGNQALAEPMDTERKRRMFDLMVTMGYKEIEV
                     GYPSASQTDFDFVRHLATSGAVPEDVTISVFTAARNDLIDRTIASIEGLPRTVVHLYTA
                     TAPAWRDVVLGRSRTELHGMILDAAGYLMRRAEEQSGADIRFEFSPEVFNLTEPDFVLE
                     VCNSITELWDASPDRPVIHNLPATVEIATPNVYADQIEYMDRHLARRDAVILSVHPHND
                     RGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLYAQGVNPMVDFSDIDAV
                     REVVEHCNRLPIHPRHPYVGELVHTAFSGTHQDAISKGMAHHTKRAAELGVPAKQAPWE
                     VPYLPIDPGDIGRTYEEVIRINSQSGKGGIAHLLHTHHGLDLPKRMRPDFSGAVQRATD
                     ASGQELSHKDLWDLFRTHYIAPAQDGPVLLNSWSTTETGPGEHRFSCVLTANGQERSYE
                     GTGNGPLSAFTQVLTSAGIAVDILNYAEHATSVGPGSPAVAYAECRVDGETFWGAGWDT
                     SILAASVQAVLAAVNRAGQAGR"
     misc_feature    12030..12041
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            12048..13277
                     /locus_tag="DWB77_RS03235"
                     /old_locus_tag="DWB77_00642"
     CDS             12048..13277
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570251.1"
                     /locus_tag="DWB77_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00642"
                     /product="MFS transporter"
                     /protein_id="WP_120719780.1"
                     /transl_table=11
                     /translation="MKKGQLGFLAGTHVVNDLYQGAIPAMLPLLMSQRHYSYAAVSGLA
                     FAASGVSSLFQPLFGLLSDRKPRSWLVPVGFATAAFGVVAAGLAGNYLLTWLCVALAGI
                     GIAAYHPPATSEARAAGGSSQKAMSVFSVGGTVGGSLAPALVTLVIGSLGFSSSYLLAI
                     PALAMVALWLLRGPWMRWRGYTPAAPLVIRAPAGTGAQDGGRRDDWRSFTRLVVVIIGW
                     SIPFVTVTSLVSLHAQRDLGQSAGAGATVLTCYTAAGAVGTLLGGWVGDRYGRMASVRI
                     GYLVALPALLGIAWAPAFPVLVVSTVVFGAAMFLPFAAQVTLAQDYLPNRPGTASGLTL
                     GLAMAAGGLCSPLFGWLADRAGLGATFYALLAVFVAPVVLALRLPDHKAAGTEHPAPTS
                     ANATEFSRNT"
     misc_feature    13439..13455
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.43"
                     /tool="antismash"
     gene            13464..13832
                     /locus_tag="DWB77_RS03240"
                     /old_locus_tag="DWB77_00643"
     CDS             13464..13832
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MannoseP_isomer"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019498.4"
                     /locus_tag="DWB77_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00643"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_120719781.1"
                     /sec_met_domain="MannoseP_isomer (E-value: 2.1e-05,
                     bitscore: 23.2, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINWDDHEELKAEGIALARRFAFGQEMSCLKVVADQSGDLNLPP
                     HWHENEQWVVVTEGSIRFVCEGTEYELNSGDVAYIPARSRHTATFVGEEGAVLLEFSAP
                     PRLDLAPGSIVPSSMKFD"
     gene            13876..15411
                     /locus_tag="DWB77_RS03245"
                     /old_locus_tag="DWB77_00644"
     CDS             13876..15411
                     /NRPS_PKS="Domain: AMP-binding (17-415). E-value: 8.1e-88.
                     Score: 286.7. Matches aSDomain:
                     nrpspksdomains_DWB77_RS03245_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="DWB77_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00644"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_120719782.1"
                     /sec_met_domain="AMP-binding (E-value: 8.7e-87, bitscore:
                     290.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSMYGSTNGEATIHDAFARVARQFPDRPAVVSAAGATTYAELAA
                     EARRIAHHLGGLGIRPGSVVPVVARRSSELAAVLLGILMAGGAYGILDVRWPAARIAQF
                     LDTMGAQVVLADTAGSAGLEQAAIGHLTFSELLDPAAPQSAPSRPLPTVAPDACATVFW
                     TSGSTGTPKAVLSPHRATTRLFTPEPFMDFGERPVMIHAAAVAWDAFTLELWGMLLTGG
                     TAVVHDGDLLLPPAIRAYISDFGATHLFLTPSLFDVIAAGDIDCLAGLRAVLLGGDKPS
                     PASCRRLFEAHPGMELYNGYGPVEACVFASTHRITEADTAQAGGIPAGRPVPSTDLHVV
                     RDGSLVPPGETGEIAIGGAGLALGYLNAPEQTAAAFTNVLVDGHERRVYLTGDHGWIDD
                     VGRLRFAGRKDAQLKVAGHRIEPAEIESAARSLGSRRSVLMPIPDRSGTPRIILFAETP
                     DDSMTEADMKGRLGKLLPAYMVPAKVHFVSAMPLLENTKINKRELSARFGYVS"
     aSDomain        13927..15120
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS03245_AMP-binding.1"
                     /evalue="8.10E-88"
                     /label="DWB77_RS03245_AMP-binding.1"
                     /locus_tag="DWB77_RS03245"
                     /protein_end="415"
                     /protein_start="17"
                     /score="286.7"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FARVARQFPDRPAVVSAAGATTYAELAAEARRIAHHLGGLGIRPG
                     SVVPVVARRSSELAAVLLGILMAGGAYGILDVRWPAARIAQFLDTMGAQVVLADTAGSA
                     GLEQAAIGHLTFSELLDPAAPQSAPSRPLPTVAPDACATVFWTSGSTGTPKAVLSPHRA
                     TTRLFTPEPFMDFGERPVMIHAAAVAWDAFTLELWGMLLTGGTAVVHDGDLLLPPAIRA
                     YISDFGATHLFLTPSLFDVIAAGDIDCLAGLRAVLLGGDKPSPASCRRLFEAHPGMELY
                     NGYGPVEACVFASTHRITEADTAQAGGIPAGRPVPSTDLHVVRDGSLVPPGETGEIAIG
                     GAGLALGYLNAPEQTAAAFTNVLVDGHERRVYLTGDHGWIDDVGRLRFAGRKDAQLKV"
     CDS_motif       14350..14409
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS03245_0001"
                     /evalue="1.00E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="DWB77_RS03245"
                     /protein_end="178"
                     /protein_start="158"
                     /score="18.2"
                     /tool="antismash"
                     /translation="ATVFWTSGSTGTPKAVLSPH"
     CDS_motif       14914..15003
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS03245_0002"
                     /evalue="7.50E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="DWB77_RS03245"
                     /protein_end="376"
                     /protein_start="346"
                     /score="43.8"
                     /tool="antismash"
                     /translation="PPGETGEIAIGGAGLALGYLNAPEQTAAAF"
     CDS_motif       15088..15153
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DWB77_RS03245_0003"
                     /evalue="1.10E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="DWB77_RS03245"
                     /protein_end="426"
                     /protein_start="404"
                     /score="30.4"
                     /tool="antismash"
                     /translation="FAGRKDAQLKVAGHRIEPAEIE"
     misc_feature    15480..15494
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            15488..15919
                     /locus_tag="DWB77_RS03250"
                     /old_locus_tag="DWB77_00645"
     CDS             15488..15919
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DWB77_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DWB77_00645"
                     /product="hypothetical protein"
                     /protein_id="WP_120719783.1"
                     /transl_table=11
                     /translation="MSTQSRTEEKFSLALESIQSKRRIERVMEAANALLDRYAKEQDPQ
                     ERLRLAFELIRRNFTEEVSISFGDLSFTTDEKAPEEGSRGTTRFHCDIVGAEGRSGTLT
                     AFYTAPGSMGLTDSEWLDAMRLLAGISGLGVGGYVTCSG"
     misc_feature    15524..15526
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15994..17085
                     /locus_tag="DWB77_RS03255"
                     /old_locus_tag="DWB77_00646"
     CDS             15994..17085
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="DWB77_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00646"
                     /product="cytochrome P450"
                     /protein_id="WP_216826820.1"
                     /sec_met_domain="p450 (E-value: 2e-24, bitscore: 84.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPGTDVHRLDDGLFAATGNAAVHEVLTHPGIVAEHPLKASARAF
                     GPNVLDADGPAHRAFRALLAPVLSGGRIAEYKQTLMPRLIDALVDAIAGTETDDFYNSF
                     AHKVPYGIVCTILGIDPALEDRFHKLTRPLARLLDYPTEETAQTHANVSELLRLIEEQR
                     AVGAADPRSLLETIERTRDRKGITLTDSEVRSTALLFFLAGTETSSAFITSLVYCMGRS
                     IFDLDELRDEVARDEFIEEVLRLYPPVQTIVRFAADDVTVHGVDIPRHSAVLASIAGAN
                     RDPRIFDHPDRFTTGRSLKGSIPFAVGAHACPGAMLAKAEFSLLVERLVERCSEVVVTR
                     DQLAMESQSFAHPAGFSVHFRTK"
     gene            17116..17352
                     /locus_tag="DWB77_RS03260"
                     /old_locus_tag="DWB77_00647"
     CDS             17116..17352
                     /NRPS_PKS="Domain: PP-binding (6-59). E-value: 4.5e-08.
                     Score: 25.3. Matches aSDomain:
                     nrpspksdomains_DWB77_RS03260_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="DWB77_RS03260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00647"
                     /product="acyl carrier protein"
                     /protein_id="WP_120719785.1"
                     /sec_met_domain="PP-binding (E-value: 4.2e-05, bitscore:
                     22.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGKIALLREWLGDLHEEPVSIQGDTDLVESGVVTSLQFVQMVIE
                     IERLHGRKLDPGVINIESMRTLDAINTTVFQAA"
     aSDomain        17134..17292
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DWB77_RS03260_PP-binding.1"
                     /evalue="4.50E-08"
                     /label="DWB77_RS03260_PP-binding.1"
                     /locus_tag="DWB77_RS03260"
                     /protein_end="59"
                     /protein_start="6"
                     /score="25.3"
                     /tool="antismash"
                     /translation="LLREWLGDLHEEPVSIQGDTDLVESGVVTSLQFVQMVIEIERLHG
                     RKLDPGVI"
     gene            17352..18092
                     /locus_tag="DWB77_RS03265"
                     /old_locus_tag="DWB77_00648"
     CDS             17352..18092
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="DWB77_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00648"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_120719786.1"
                     /transl_table=11
                     /translation="MGSDTSRVAVVSGTSSGIGAAVATEFLNRDYTVVGLSRRGNPTLA
                     QEKGYVDCVADLRDDSAVRSALDSVSSTTAGGVRAVVLNSGVSPDPVDLRKLDWQVAAD
                     AYENNVHTALSLIQATAPLLGRGGDGSLTFVGASLANGYQPDRWAYAASKAAMTALMRA
                     CSVEFADDGVVANEVRPGPVATAMTLAGLDGEVSDQVIRAINEGFGTDWLKAPRTVAEW
                     IVSIAEFPSNGPTGQVFNYSRKVL"
     gene            18162..18983
                     /locus_tag="DWB77_RS03270"
                     /old_locus_tag="DWB77_00649"
     CDS             18162..18983
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024586.4"
                     /locus_tag="DWB77_RS03270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00649"
                     /product="PAS domain-containing protein"
                     /protein_id="WP_120719787.1"
                     /transl_table=11
                     /translation="MSNYPSSEQLLDLFNWASPAMLVTDADGLVVLANKAAVELLADRA
                     SSGTKLADALGINGYTALLAAGEPVENLDATFVNPDFASGYANVGFGEVEGSTYGFWAL
                     RPVTTHPTPSSQAGEGNSTAQAWISQVDRSNAAYTPVGEDAVKFIRAYYDNCPVAIHLI
                     EEDGTVAHANWKDIAIVGASEQPDTYVGHHIRHIYADQEVVEDFLGRWGEDAPIIDFRA
                     DFLNKGERVPVVIFSTAKVEDNKLKNTRCFVFPDSHPDRKRDKVKALDLNF"
     gene            19103..20482
                     /locus_tag="DWB77_RS03275"
                     /old_locus_tag="DWB77_00650"
     CDS             19103..20482
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714352.1"
                     /locus_tag="DWB77_RS03275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00650"
                     /product="nitrate/nitrite transporter"
                     /protein_id="WP_120719788.1"
                     /transl_table=11
                     /translation="MADTTAGRGRWLTGWDPEDEDAWDRGGDRIARRNLILSVLAEHIG
                     FSVWTLWSVLVLFMSPAIGLGFNPGEKFLLVATPTVVGALLRLPYSYAVTRFGGRNWTV
                     FATAILLVPALLALYFVQRPGTPLWVFLVIGATAGVGGGNFASSMTNITAFYPQRHQGW
                     ALGLNAGGGNLGVAAVQLVGLAVISLAGNTHPSYVAAVYLPLIVVVALLAAWKMDNVDA
                     VRAEPGAQREAARHRDTWWISLLYIGTFGSFIGYGFAFGLVLQNEFGSTPLQAVGYTFL
                     GPLLGSFSRPLGGKLADRKGGARVSLWNFLGMGAGTVVLIVAAGLHSFALFIGGFTALF
                     VLSGLGNGSTYKMIPAVFAKKAEDEITRGHDASGAFARARRLSGAVIAIAGAVGALGGA
                     AINLAFKLSYANGSSSGIPAFVVFLAYYALCVAIIRFVYLRPSATGGGHTTKSVKEASH
                     V"
     gene            20475..22571
                     /locus_tag="DWB77_RS03280"
                     /old_locus_tag="DWB77_00651"
     CDS             20475..22571
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886468.1"
                     /locus_tag="DWB77_RS03280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00651"
                     /product="molybdopterin oxidoreductase family protein"
                     /protein_id="WP_120719789.1"
                     /transl_table=11
                     /translation="MSELGPPLREVATHCPYCALQCGTRLAGDRETGVVVRPDDFPVNR
                     GRLCQKGWTAPAVLSATDRLTRPLVRRRDGRLAEASWDVALERVAGELRRIRAEHGPDG
                     VAVFGGGGLTNEKAYLLGKFARLALGTSQIDYNGRFCMSSAAAAGNAAFGVDRGLPFPV
                     TDLQGARTVLLAGANVAETMPPLMQHLDGAELIVMDPRRTASAQRAALHLQPAPGTDLA
                     LALGLFHIAAVDGLLDRNYIQDRTRGFEAALRRAMDWWPERVEAVTGIPASDQRAAVHM
                     LARAGGAYVLTGRGVEQHSTGTDTVAGFINLALALGLPGRAGSGYGCLTGQGNGQGGRE
                     HGQKADQLPGYRSITDPAARAHVAAVWGVAPQELPGPGRSAYELLDALGGDRGPRALLV
                     FGSNPAVSAPHSTRVTERLAALDLLVVADFVPSETARLADVVLPVTQWAEEEGTLTNLE
                     GRVLRRRARLSPPGQVRSDLQVLHELAVRLGEPASRYPTVPQEVFDELRAASRGGRADY
                     AGISYERLDAGESLHWPCPDTPDPHPGTPRLFLDRFEHPDGRARFAAVDHQGPAEELNP
                     HYPLHATTGRVLAHYQSGAQTRRVAELNDAVPGPFVEMHPDTALRSGVSDAGLARVISA
                     RGSMTARVRVDPTMRLDTVFAPFHFPGEGRANLFTHPALDPHSGMPSFKVCAVRVEPVS
                     GVAP"
     gene            22568..23965
                     /locus_tag="DWB77_RS03285"
                     /old_locus_tag="DWB77_00652"
     CDS             22568..23965
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.4"
                     /locus_tag="DWB77_RS03285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00652"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_162952389.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-31, bitscore:
                     108.9, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 4e-12, bitscore: 45.1,
                     seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVLVLGNGPTAHHFADRLRQHGHEGPLTLLGTEPGATHHQAFL
                     DALLAPADLQLPPPPGLDVRTDTRVVAIDRAQRRVRALVGEAETVFPYDTLVLALEARP
                     LLPRLPGIAAPDGRLGPGVVVPRTAADRERISGESAVVLGGGPQAVEIASALAARGTRT
                     TLVCERPHPLEERLGETCAAWLAERLERAGVTVLGGRTAVRRTPGRLHLDDGTVLPADT
                     LVLCPSVVPDLELAVAARLLTDSGIVVDAQLRSSDPHVHAIGPGVEHEGRATEGPAAAL
                     EQADTLARILTGRGGTYRAAPPVLRLRIRAADVCHIGTPADFDGPDTRLVTLTDPKERR
                     YARLALRGERVVGAVLFGLPGAIAPIVRSHRLSQQLPYDLVGLLLGWPPRSASDAAEPE
                     ARSLVCLCNSVTETALRQAWQAGARTVPALATATRVTTGCGGCGERVRELCAAWAPGRH
                     TELKDAA"
     gene            23962..25182
                     /locus_tag="DWB77_RS03290"
                     /old_locus_tag="DWB77_00653"
     CDS             23962..25182
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138963.1"
                     /locus_tag="DWB77_RS03290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DWB77_00653"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_120719791.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-51, bitscore:
                     174.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRLVVVGHGMVGHQLVDRLTSLDTEGTWRIVVLGEERHLAYDR
                     VSLSSYLDGKSKDDLTIAGPVLRHDARVEVRLACPAVSVDRTSRTVTTADGDDIAYDAL
                     VLACGSRPFVPPVPGHDLVGCFVYRTFDDLDAIRAAARAGRPGLVIGGGLLGLEAANAL
                     RLLGMHPHIVETAPHLMSAQLDPGAARVLHQQATELGLRLHCSTATASIEARPDGTVRA
                     VRLSDGTVVETELVVFAAGIRPRDELAVSAGLALGERGGIAVDDRCRTRDGRVWAIGEC
                     AAVEGRCHGLVAPGYRMADNVARQLMGQDTEPFDGSDTATTLKLLGVNVASFGATRPAD
                     GQALEVVFAQGSTRYAKFFLRRDSGALLGGMVAGGTASPLALASFLGRRPPADLEQLLA
                     PDLPFLP"
ORIGIN
        1 ggcgtccttc ggcaggagct ggtccaggac cgaggcggcg gtccgctcgt cggcgccgtc
       61 caggagccag ggcaggagcc gcgccgcgca gggttcgatc caccgggcgt gggcgcggcc
      121 gaagaattcc cactgctcct ggctcaagac ggcctgaacc agcggcaaaa ccgcctcctc
      181 ctcgtggtcg aggtgcttgt cgaggccggt gaccaggcag tcggcgagtt ccgcgagcag
      241 gtccggtccg gccgcgacgc cggtcagccc gtcgtcgacc gctccgacga ggaagacgag
      301 agcggcgtgc tcggcctcga tcgcctccag ccgtgtcagg tcgaaggggc gaccggccag
      361 ggctcggcgc agcgggggcc acaacgcctc gtcctcggcg gcttggtgta cgtgcagggc
      421 gctctggaac atccaccagc ccggggccgc gcgcagggca cgccgtaaac ctgcgcggtg
      481 gacggtgatt gcccgcgcga cgttccccaa ctccctgcgc agcgcgttgt gcaccacgcg
      541 ggtcacggtc atgtcgagcc tctcgctcac gtaggtccaa ctcccgggcg tcaatggctt
      601 gttgaggctg cgtcaggact cgacgcacac gtcgttcctg gcacatgcca gcctcctccg
      661 gagccaccgc gggatcaacg cggactttgt gagcccatcg ataactcagc ggttatcgat
      721 gccccgcctc ccccgcctcc ccgtctcccc cgtctccgct tctcgcgcga cgccttcgcg
      781 tggcgccctc gctcgagaag ccctctggga cacgcctcct cataccggcg tggtgtcggt
      841 cgggtggaac gggctgccgt ggcccggcac gatcaggtcc gccgtggcca tcacccgcag
      901 ccgggaggcg cgcagcactt cacggtccgg ggccaccggg tcgtccgccg ggccgttggc
      961 gtgccaccac aggtcgcccg cgaaggccac cacgccctcg tccgtgcccg ccaacagcgt
     1021 gatgtcctca ggactgtggc ccggggtgcg gatcagacgc agggacgggg tgagttcata
     1081 gccctcggca tccctattcg tccactggtc gtccaggtac tccaccttgt ggtcgtgcac
     1141 ccgggcacgg ccgaagagac ccacgttcat ggtgttgtcg gggtggtggt ggctgaggac
     1201 gacgtcggtg atgtcctcgg gggcgaggcc tagttcggcg agcggcgcca ggatgtcgtc
     1261 gcggctcgcc accatgcccg ggtcgaagat cacatggcgt cccgcgtcgg agacatagga
     1321 aacggtcgcg gcgaccccgg ggccggtgga gcccacgtaa ccggtggtca ggaccttgaa
     1381 tgcggcgctg cggccgagcg gtgcgtttgt catgaccgca atcctgctgg gaccgaggca
     1441 gggtgacgag tggcacctct gcccatgatc gcaggattcg tgccaccctc tgccacactg
     1501 cactcatgcc gcccttcaaa accgtcgccg cgtacgcccc cgccggcgtc ggcatgctcg
     1561 ccgtcggcat cgtcagcgag gtgttcggcc cccatggagc ggcgctgccc ggcttcgact
     1621 tcgcgctctg caccgaccgg cccggagagg tggccgcgga ctgtggagta ccgctctccg
     1681 tccgacacgg ggtggaccgg ctcgccgaag cggacctcgt gatcgccctg cccggcgccg
     1741 gcttccgcac accgcccgcc ccacccgtac tcgacgcgtt gcggacggcg cacgcgcgcg
     1801 gagccgtggt cgcggcccac tgcgtcggta cgttcgcgct cgccgccgca ggactgctcg
     1861 accagcgcag ggcaaccacg cactggcggt tcgccgagct cctcgccggt cggtttcccg
     1921 gggtcaccgt cgaagccgac gccctctaca tagatgaggg cagcatcgtc acgggcgcgg
     1981 gtgccgccgc gggcttcgat ctgtgcctgc acctgctgcg gcgggagtac ggcgccgcgc
     2041 aggccaatgc catcgcccgg gacatggtgc tgcccgccca ccgcgacggc ggccaggccc
     2101 agtatctcgc cacgcccgtt cccgaggacg gtgatgacgt acggctggcg gaggtcctcg
     2161 cgtgggcccg ggagaacctc cacgagccgc agtccgtggc ggagttggcg catcgcgcca
     2221 tgctgagcaa gcggaccttc gcccgccgct tcaccgccgc gaccggcacc accccgcacg
     2281 cctggctacg acacctgcgg ctgagcaggg cggaggagct gctggagacc acggacctgg
     2341 ccatcgagga gatcgcccgc caggtcggtt acggcagcgc ggccgtactg cgcgaccagt
     2401 tcgtacgacg ccggggcgtc ccaccccgct cctaccggca ggccttcacc accgcgcccc
     2461 gctgacccgt aagtgccagc cacgctcagg cggaggggcg ccgccgggta ccggcgccgc
     2521 taccgccgcc cgacccgttc aggggaatca gggtttccaa aggggcgccc ttgacccagg
     2581 cgccgagcag atctcggtgg atggccacga tgtcctggcg cagcgccagg cccatggcgt
     2641 ccttggtgaa ggcgcggcag gtcgcgacga acagggcgac gtccgcgcca tgttccaggc
     2701 gtgcggtgcc gacgaacttc tgcatgtcct gtgacggcac gctgcggtgc ggggcgtact
     2761 tcttgcactg gatgacgagt ttgcggccgt cggcgagata accgatgaca tcggcgccca
     2821 agtccccgct gcggccgctg acgacgacct tcgtgcagcc gtcccgccga cacagttcgg
     2881 cgatgtacgt ctcgaactcc tgccaggaca gcgcgtcgac ctgcgccatg gacaactccc
     2941 gggccttcgc ctcctcctga gcccgccatt cgcggtcccg tgagaccgcc gtacggtgcg
     3001 cccgccacac cacccacgcg acacaaccca gcacggccgc gcccaacacc gtcaccagga
     3061 caggccacac cgccgaccag tgcgcggcca gccacaccac cgcgaccgcc cccacgatcg
     3121 agctccagcc ctggacttgc ctgagcgtcc gcttcctcat gcgccaaagc cgtcgctgtg
     3181 ccgccatgac tcccccactc ccgcactccc ccaccctgcc ccgcagtctg caagccgttc
     3241 tcacgccccg gcaagagggc cctcatgcca gaagacccgc acccacattt cccactgatt
     3301 tactaggaaa gcattgacgc tccgtcggtc cggtgcgcag gatggggcca tggccccctc
     3361 gcagcgacga ctcgttcgcc gacggcacgt cgacttcggt cgcgtcacca gtgccgcctg
     3421 tcgccacgcg tagagcaccg cgctcacgcg tcttggcccc gtacgggcgc ccggatcgct
     3481 gcttggccaa gggatgcacg taccttgatc caaccagtgc gcggccccaa caccccaccg
     3541 tcctaccgaa cttgaggagc gccgccatgg gcgttgcgat cgcgccgtcc gttaccgctt
     3601 ccgatgccgg ccggatcggt ctcagccgta cacactggtc gcgcgtggcc cgcgagaccg
     3661 ccgacgacct ggccacggac gccgtggcga gggagcaggc gggcaaggct cctttcgacg
     3721 aggtggcccg tttgcgtgag gcggggctgt tgacgctcct cataccgcgc gagttcgggg
     3781 gaggcggcgc ggactggtcg acggcctgcg gcgtcctgcg ggagatctcc gccgccgatg
     3841 gcgcggtcgg tcaactgctc gcctgtcact acttcctgtc gtggagtgcc cgactgttcg
     3901 ccggaccggc tctggccgag gaggtcgagc ggaagtccgc ggcgcagcag tggtgttggg
     3961 gtggtgggct cggcggccac gatctgcctc tcacgctgac caggaagggc gccggctatg
     4021 tgctcaacgg gcggcagaac tacgccaccg gcgtcctggt ggccgaccgc atcgccgtgc
     4081 gggcggagcg ggccgacacg ggcgagacct tcgccgtcgt cgtcgatgcc acctgtctcg
     4141 gcgtacggat cgacgacgat gccgacacct tcggccagcg gctcgcggcc ggcggaaacg
     4201 tggagttcga tgccgtaccg gtcgccacca aggacatact cggctccctg tccgaggacg
     4261 aggacgtcct gtcgccccgg accgctctcg catcgccgat cgggcgtctc ctctcggccc
     4321 agctcctgct cggcatggcc gaggggatgc tcgccgaggc aagggagtac ggcagggcgg
     4381 cccactcccc ctggcgcccg gactggccga tcgggtcgct tcaggacccg cacgtcctga
     4441 ccacctacgg tgagctgacc gtcctggccc gctccgcctc cgccctcgcc gaccaggcgg
     4501 tcaccggcgt tcaggccggg ctggcacgcg gcgaggagct gtccttcgac gagtacgcgg
     4561 agatctccgt cctcgtggcg atggcggaag ccgccgcttc caaggcggcg caggagtcga
     4621 ccacccgtgc cctggacgtg atcggctccc gctccgcctc cgcgcggctg ggcttcgacc
     4681 gcttctggcg caatacccgg gcccacacgc tgtacgagcc cgtcgccccc cggctccgcg
     4741 acgtcgggga ctacttcctc aacggcgcgc accccgcgtt cacactccct gcccgccctt
     4801 gaggaccggg agccccacgc ccgtcacacg ggaggcggtg tctcctctgc acggcggcgc
     4861 ccagcgcctt gaacgccgag cggctccgta cgggatactg cggacatgag gatctcagcc
     4921 agggccgact acgcggtacg cgccgcgttg cagctcgccg cgtcacgcga tgccgcgccg
     4981 ctgaaggccg aggccatcgc cgaagcccag agcatcccgc acaagttcct cgaaggcatc
     5041 ctgaacgaca tgcgccgggg cggtctcgtg ctcagccagc ggggcgtcaa cggcggatac
     5101 cggctggcca agcccgccga gtccatcagc atcgccgacg tcatccgcgt cgtggacggg
     5161 ccgctggtgt cggtacgcgg agtacgccct ccggagctgt cctacaccgg gcccgccgca
     5221 tccctgctcc ccctgtggat cgcgctgcgg gccaatgtgc gcgagatcct ggacggcgtg
     5281 tccctcgcgg atgtcgcgtc ggcccaactc ccgtcccccg tctcggagtt ggccgacgct
     5341 ccaggggcgt ggacgaaccc ctgaggcgcc ggaccgctca ccttcgacgc aagcgcggcg
     5401 tgacggactc ggatcccggg gcgctcactc ctgaacgatc ccctccgccc cgaaccgcag
     5461 ggcgcagtcc catgtgtcga cgtcgctgaa cagcaactgc accagttcga tggaccactt
     5521 ccagtcgcag ttcttcaccc cgaacagcgc ggccagggtg tcccgcaggg gcatgccgat
     5581 gtagcgccgc ttcaggccca cccgggacgg gacgcgtacc gagccgaggt cctcggccgt
     5641 gacgggaccc cgctgcacca gccactcctc gatgaaggac tgggtcacgg gctgcccctt
     5701 ctcctgggcc gcctccacca gggcggtgcg cagcgcgtcg gcgccacccc cttcacagag
     5761 gccggccagc caggttccga gctcggggcg gagttcgaac gaggtgtcgt tcgtctgtcc
     5821 ggcgctctgc tgcttgcgcc acttgtcgat cttctccatc gcgccgtact gctcgtcccc
     5881 cgtgaagtcc tcgtggtcgg ggccgccgcc gaagttctcc aggttggccg cttgcgtacc
     5941 gggcgatccg ctgctgctga tcatggtggc gttggaggtg ccgtcgggcc ggtggaacgt
     6001 gccggccatg gtgtagatga ggccgttgag gtcgtccggc gacgtgatgt cgagctccat
     6061 ctgccgggcc gtcctgatga cgtcgtagta gtacaggtgc gcgcccgact ccttgatcgc
     6121 gttctgcacg gtctcgctga gcagagcgct ttcgacggag ttctccacga cgtcgacgcc
     6181 gccgaactcg gcgagcagcc ccgcgttcgt ctcgcccacg ttgccgagcc cgatctgagc
     6241 ggcgacccgg tcgcccttca gctcggtgag gacctgccag gcctgtgcga gcacccgctt
     6301 gtcgccgtcg aggttgtgga tgacgaggct gtcgaagcgc ccgtggaaca gggcggcgac
     6361 ccgttcgagg cgggcgcgca gcacgtcggt cgactcgccg gagcggacgt cgaacttgta
     6421 caggatctcg tagctgtcgc gcggcagacc gctcagcacc tcggacacga gctcggtgtt
     6481 gcggtagctc tccgccgtgt cgaagcgccg gtaccccgcg tcgacggcgc tggtgagctg
     6541 ttccttgctg cgtccgtcca cgccgaagac cagccacggc ttggctgcct cggacgcgtg
     6601 ggtgtcggcc ggcatccggg cgatcaccgg ggaatgctgg tgccgggggc cgtcatcggg
     6661 cacggtggcg cgctggagcg gcgccgaacc ggccatcgcg cggcgggcgt tggcctccgc
     6721 cgcgcgctcg aacgtgtccg aggggtccga gacgcgcagg ccgtcgccgc ggtcggtacc
     6781 ggtgaccggc ccctgacgct gctggatgac atgggtcaac tcgtgggcca gcgtgtgctt
     6841 gtcggcgccg ttgtcgccga ggacgacgtg gtcaccgctc gtataggcgc gtgctccgac
     6901 ttcggcggcg gacgccttgg cttcggggcc gtcgtggatg cgtacgccgg tgaagtcggc
     6961 cccgaggcgg gcttccatgt ccgtccgggt gtggtcgtcc agcggacgac cgggcgcgcg
     7021 cagcacatcg tggacggccg agcgccgctg caccgccacg gcctctgcct ggccatgctg
     7081 ctgctccccg cagccgtccg tgggggcgtg ctggtcctgg gaccaggcgt ggccggaccc
     7141 tcgaagcatc tggaccacgg ccgcgttgcc ggcggcgccc tggagtgcga ggagccgagg
     7201 gggtatcgca ctctccggag ccggggccct gcccgcgccc ttgcggggcg tcctgctctg
     7261 gggggtccgg gcctgctcgt tggcgtgcat ggggtcctct cacggacgcg agccggaact
     7321 gggtctgcca gcctatagct acgcccctaa cccgggtaac tgcgcctgga atccggccac
     7381 ttcgttcccg gccacatagc ggttgcgtgg gccccaagcg tgaggccggc cccttggggc
     7441 gtggtgagga ttgaagtcac cacgcggctg gaaggggtcg gcctccggcg gttctctccc
     7501 ttaccagggg taccaagcgc cgttgtacca ctgctcgttg gagtcgtcgg cgtggtggtt
     7561 catgtcgaag tccggccagt agttgttgtt gtggttgccc gggtaggtcc agaagccggc
     7621 ggactcgtcg cagatgtagt cccagtagca gatggacttc accggcacgt tgccgaagtc
     7681 ccggtcagcg cccgagagcg gagggccgat gacgccgccg aacggtgcgg cactgccgtt
     7741 ggtgccggga ccgccctgcc gcttggggtc cgcgatgagg actgcgttga cgttgtcgaa
     7801 cgtcctccag ttctcgctga cccacacgtg gaccaccgcg gcacccaggg agtagccgcc
     7861 catcttgacg tgctgccacg ggcacgcggc acgctgttcc cggaccagcc ggttcagctc
     7921 gccgacgccc tgccggacgc tcgggccgct cggtacctgg ctggcgtagc ccacgtgctg
     7981 ctggatgttg ccgacgaacc ggtcgttgtc ccacgtgctc cacgtgcccc cgacgacgat
     8041 cgtgtacgtg ccgtcgcacg gggctgtgac cgcctgtgct ggggatccct gcgccagtga
     8101 aagcccggat gtcagcagga gagcggctaa cgcggccgcg atccttcctt ttcgcatgcg
     8161 gttctccctg tgtagtgggc ctgcccgtct gccgcccggt gcggtgcacg gtcggccgag
     8221 ttcatgaacg accgtggcag tgacggatga aattccactg aaaccgccga gggatcgaga
     8281 catgccaggc gttgcgtccc cggtacgtca tgccacggcc gggggcgggg tcgggctggc
     8341 gccgccctgc cgtcaggagg ccgctcgggc gcacagggcg cgtaggacgt ccgccacctc
     8401 tccggcgcgc tcgttggtga agaagtggcc gccgtggaag gtgtgcatcc ggaaggtggc
     8461 agccgtgtgc tgttcccacg cctggacgtc ggcggggtcg gtgagcggat ccgcgttccc
     8521 catgagggcg acgacggggc aggcgacggt acccccgggc tccggccggt agcggccgtg
     8581 ggcggccaga tcgccgcgga tgacgggcag gaatacgctc cgcaggacgg ggtggtccag
     8641 gagcccggag tcgtcgccca gcgaccggag cagatcgacg agcggctggt ccggatcctc
     8701 ggtgccgtcc ccgggcggga cgatggacgg caggccgagc cgggacggcg cggggtgccc
     8761 ggaggccacg aggaccagcc gccgctggtc ggccgtcctg cggacgacct cgtacgccac
     8821 gaccgctccc aggctgtgcc cgaacaggac gacgggcccg ccctcgtgcc acgcggcgaa
     8881 cgcctgggcc aactcgtcgg cgagggcgtg cacatcggtg aagggcgggc tcgaacggcg
     8941 ctccgcccgg cccgggtact ggacgcaggc aggccgcgcg gtgtcggcga gccggcctgc
     9001 gaggccccgg taggagccgg ccgagctgcc cgagtgcggg aagaacagga gctgcgggtg
     9061 gccgtcggcg gacgccgtgg tcgggaaggg gcggatgtgc ggggcgaacc ctgacggtgc
     9121 gtcagatcgc atgaaggcgt tcgagggtcc gcttcagttc ttcgcgcagg gttcgcccgg
     9181 cggactccgc gtccgcgcgc gcgatggcct ccaccagcag ggtgtggccg tcgtcgccgt
     9241 ggttggggtc cccggagcgc aggccgagca gctccaccag gtcgatcagc ccctggcgca
     9301 gtacgggcac gaactcggcg aacaggccgg tcagtacggg gttgtgggcc gcggcgacca
     9361 cggccgcgtg gagggcgatg tcggcgtcga cgaactccgc gtcacccgct tccgctgcgt
     9421 ccctgcggtg ggccagcgcc ttgtcgaggg cgacgaggtc atcgtcggtg cggcgctgcg
     9481 cggccatctg cgcggcttcg acctcgatga gcatgcgcac ttcgtacaca tcggtgacgg
     9541 ccgcgcgccg caggctcgtg ggccagtcct cctggggctt ggtggcgatg acgaagacac
     9601 cggcgccctg acgcggctgc acgagtcccg cgccggccaa cgcgcgcagg gcctcacgca
     9661 cggtcgagcg tcccacgccg aggatctggg cgagcgcgtt ctcgccggga agtttggtcc
     9721 cgacgctcca ctcgccctgc gtgatctgct cgcgcagccg ctcagtggcc tgctcgacca
     9781 agggagttgg ccgcagtgcg cccagtggca ttcgacgttc accttcgctt tcacatctcg
     9841 ggttgtctga ggtgttggat tgtggttact gtacccggca tgtcgctgtg cgagcttctt
     9901 cttctcggtt gccgctgcgg ggcctgaatc gaccggcacc ccgcagcggg tgtcgagacg
     9961 tgccggtcac cagttggccg actgaaagtg gttccgtctc atggctacat cccccaccca
    10021 ggctttcgcc acgctgcgca ccccgtcggg gcccgttccc gagggtgctc ccgcgtggaa
    10081 cccccagcgg ccgagcgcga tgccgcacga gcggtaccgg cccgcgcacg accgcgtggc
    10141 gctgccgctg accgaccgga cctggccgtc gcgccgactg gagcgggccc cgctctgggt
    10201 gccggtcgat ctgcgcgacg gcaaccaggc gctggccgag cccatggaca ccgagcgcaa
    10261 gcgccggatg ttcgacctga tggtcaccat gggctacaag gagatcgagg tcggctaccc
    10321 ctccgccagc cagaccgact tcgacttcgt gcgccacctg gccaccagcg gcgccgtgcc
    10381 cgaggacgtg accatctccg tcttcaccgc cgcccgcaac gacctgatcg accgcaccat
    10441 cgcctccatc gaggggctcc cccgcaccgt cgtgcacctc tacaccgcga ccgcaccggc
    10501 ctggcgcgac gtggtactcg gccgctcccg caccgagctg cacgggatga tcctggacgc
    10561 cgccggctat ctgatgcggc gcgccgagga gcagtcggga gccgacatcc ggttcgagtt
    10621 ctcccccgag gtcttcaacc tcaccgaacc ggacttcgtc ctggaggtct gcaacagcat
    10681 caccgagctg tgggacgcct cccctgaccg gccggtgatc cacaacctgc cggccaccgt
    10741 ggagatcgcc acccccaatg tgtacgcgga ccagatcgag tacatggacc gtcacctggc
    10801 ccggcgcgac gcggtgatcc tctccgtgca tccccacaac gaccgcggca cgggcgtcgc
    10861 gtgcgccgaa ctcgcggtgc tggcaggggc gcagcgggtg gagggctgtc tgttcggcaa
    10921 cggcgagcgg accggcaacg tcgacctcgt cacgctggcc ctgaacctgt acgcgcaggg
    10981 cgtgaacccc atggtcgact tctccgacat cgacgccgtg cgcgaggtgg tggagcactg
    11041 caaccggctg cccatccacc cgcgccaccc ctatgtcggt gagctcgtgc acacggcgtt
    11101 ctccgggacc caccaggacg ccatctccaa gggcatggcc caccacacca agcgggcggc
    11161 ggagctgggc gtcccggcga agcaggcgcc gtgggaggtc ccgtacctgc cgatcgatcc
    11221 gggtgacatc gggcgcacgt acgaggaagt catccgcatc aactcgcagt ccggcaaggg
    11281 cggcatcgcc cacctgctcc acacccacca cggtctggac ctgcccaagc ggatgcgtcc
    11341 ggacttctcc ggcgcggtgc agcgggccac cgacgcgagc gggcaggagc tctcgcacaa
    11401 ggacctgtgg gacctgttcc gcacgcacta catcgccccg gcccaggacg gtccggtcct
    11461 gctcaactcg tggagcacca cggagaccgg acccggtgag caccggttca gctgtgtcct
    11521 gaccgcgaac ggccaggaac ggtcctacga gggcaccgga aacgggccgc tgtccgcctt
    11581 cacccaggtc ctcaccagcg ccggcatcgc cgtcgacatc ctgaactacg ccgagcacgc
    11641 caccagcgtg gggcccggca gccccgcggt cgcgtacgcc gagtgccggg tggacgggga
    11701 aacgttctgg ggcgccggct gggacacctc catcctcgcg gcgtcggtgc aggccgtgct
    11761 cgccgccgtc aaccgggccg gacaggccgg acggtgaccg tgctccacgt gtcctcggtc
    11821 cgggtgagcg gcgcgccgta acccggcccg acggcgggtt gccggtgggt gtgccgaccc
    11881 ggcgcgtccc accggcaaca cccttgacca acacccttac gaggggccaa ctcacctgct
    11941 cagcaagggc tttgctgccg cccggatcgc tcgttaaggt aacacctcag aggacctgag
    12001 gacctgaggt caaccgcacc cctaccgacg gaaatgaacg gttcaggatg aaaaaagggc
    12061 aactcggctt cttggccggt acgcacgtgg tcaacgacct gtaccagggc gcgatccccg
    12121 cgatgctgcc gctcctgatg tcacagcggc actacagcta tgccgccgtc tccggtctcg
    12181 cgttcgccgc gagcggcgtg tccagtctgt tccagccgct gttcgggctg ctgtccgacc
    12241 gcaaaccacg gtcctggctg gtgcccgtcg ggttcgcgac ggcggcgttc ggcgtggtgg
    12301 ccgccggcct tgccggcaac tacctcctca cctggctgtg tgtcgccctc gcgggcatcg
    12361 gcatagcggc ctaccacccg ccggccacca gcgaggcccg tgcggccggc ggctcctcgc
    12421 agaaggccat gagcgtcttc tccgtcggcg gcacggtcgg cggctcgctc gcccccgccc
    12481 tcgtcaccct cgtgatcggc tccctggggt tctccagcag ctacctcctg gccatccccg
    12541 ccctggccat ggtggcgctc tggctgctgc gcgggccctg gatgcggtgg cgcgggtaca
    12601 caccggcggc accgctggtc atccgcgccc cggccggcac gggcgcgcag gacggcggac
    12661 gcagggacga ctggcgctcc ttcacccgcc tggtggtcgt catcatcggc tggtcgatcc
    12721 cgttcgtcac ggtcacctcg ctggtgtccc tgcacgccca gcgcgacctg gggcagtccg
    12781 ccggggcagg ggccaccgtg ctcacctgct acaccgcggc gggagctgtc ggcaccctgc
    12841 tcggcggctg ggtcggtgac cgctacggcc ggatggcctc ggtccggatc ggctatctcg
    12901 tggccctgcc cgccctgttg ggcatcgcct gggctcccgc gttccccgtc ctggtggtga
    12961 gcacggtggt gttcggcgcc gcgatgttcc tgccgttcgc cgcccaagtc accctcgccc
    13021 aggactactt gcccaaccgc ccgggcacgg ccagcggact gaccctgggc ctcgccatgg
    13081 cagcgggcgg cctgtgctcc cccctgttcg gctggctggc cgaccgggcc ggtcttggcg
    13141 cgacgttcta cgcgctgctc gccgtcttcg tggctcccgt cgtcctggca ctgcgcctcc
    13201 ccgaccacaa ggccgccggg accgagcacc cggcccccac ctcggccaac gccacggagt
    13261 tttcccggaa cacctgagga aaccccctgc ctcccaatgt cggccgccac cctcaactgt
    13321 ccagtatttg aaatggcatt gagcacggcc ggaagtacca cgtacggtcg aaacagattc
    13381 gggaaacgcc gccgaatgga actcaagggc cggcgcgcga ctttcccgtt ccgtcacgtc
    13441 gccatacgat cacaggggga ccgatgaaga ttaactggga cgaccacgag gaactgaagg
    13501 ccgaaggaat cgcattggcc cggcggttcg cattcggcca ggagatgtcc tgcctcaagg
    13561 tggtggccga ccagtccggt gacctgaacc tcccgccgca ctggcacgag aacgagcagt
    13621 gggtcgtggt caccgagggg tccattcgct tcgtctgcga gggcaccgag tacgaactca
    13681 attccggtga cgtggcctac atccccgcgc gttcgcggca caccgccacc ttcgtcggag
    13741 aagagggagc cgtgctcctg gaattctccg ctcctccgcg gctcgacctc gcccccggct
    13801 cgatcgttcc gtcgtcgatg aagttcgact gagccgggcg acggccagca actgcatcga
    13861 acgggggcat cgatcatgag cagcatgtac ggctcgacca acggggaagc gaccatccac
    13921 gacgcgttcg cgcgggtggc ccggcagttc cccgatcgcc cggccgtggt ctcggccgcc
    13981 ggcgcgacga cgtacgcgga gttggccgcc gaggcccggc gcatcgccca ccacctgggg
    14041 ggactcggga tccggcccgg cagtgtcgtt cccgtggtgg cccgcaggtc ttctgagctg
    14101 gccgcggtcc tcctgggcat cctgatggcc ggcggcgcct acggaatcct cgacgtgcgg
    14161 tggccggccg cccggatcgc ccagttcctg gacaccatgg gcgcccaggt cgtcctcgcg
    14221 gacaccgcgg gatccgccgg cctggaacag gcggccatcg gtcacctcac cttcagcgag
    14281 ctgctggacc cggcggcgcc ccagagcgct ccgtcccgcc cgctgcccac ggtcgcaccc
    14341 gacgcgtgcg ccaccgtctt ctggacctcc ggaagcaccg gtacccccaa ggcggtgctc
    14401 tccccgcacc gggcgaccac ccggctgttc actcccgagc ccttcatgga cttcggcgaa
    14461 cgaccggtga tgatccatgc ggcggcggtg gcctgggacg ccttcaccct ggagttgtgg
    14521 ggcatgctgc tcaccggcgg caccgcggtc gtccacgacg gcgacctcct gctgccacct
    14581 gcgatccgcg cctacatcag cgacttcggc gcgacccacc tcttcctcac cccgtcgctc
    14641 ttcgatgtga tcgcggccgg cgacatcgac tgcctcgccg gtctgcgcgc ggtgctcctc
    14701 ggcggcgaca agccgtcacc cgccagctgc cgcaggctct tcgaggccca tcccggcatg
    14761 gagttgtaca acgggtacgg ccccgtcgag gcgtgcgtgt tcgccagcac tcatcgcatc
    14821 acggaggccg acaccgccca ggcgggcggc attccggccg gccggccggt gcccagcacg
    14881 gatctccatg tcgtacggga cggctccctc gtgccccccg gcgagaccgg tgagatcgcc
    14941 atcggcggcg ccgggctcgc tctcggctat ctgaacgccc ccgagcagac cgcggccgcc
    15001 ttcacgaacg tgctggtcga cgggcacgag cgccgggtct acctgaccgg cgaccacggc
    15061 tggatcgacg acgtcggccg tctgcgtttc gccggccgca aggacgccca gctcaaagtc
    15121 gccgggcacc ggatcgagcc tgcggagatc gagtcggcgg cccgctcgct gggcagcagg
    15181 cggtcggtcc tgatgccgat ccccgaccgc agcgggaccc cgcgcatcat cctgttcgcg
    15241 gagacccccg atgactccat gacggaagcg gacatgaagg gccggctggg gaagctgctg
    15301 cccgcctaca tggtgcccgc caaggtccac ttcgtctccg ccatgccgct gctggagaac
    15361 accaagatca acaagcgcga actctcggca cgcttcggct acgtctcctg agggccggct
    15421 ctcctccgca ccgcgccacc ctttcccctt gtcatttggc ggtcccatac agggaaggac
    15481 tctcgttttg agtacgcaaa gccgcacgga agagaaattt tccttagcgc tggaatccat
    15541 acagagcaag cgccggatcg agcgggtcat ggaagcggcg aacgctctcc tcgacaggta
    15601 tgcgaaggag caggacccac aagagcgcct gcgcctcgcc ttcgaactca ttcgccgcaa
    15661 tttcaccgaa gaagtctcca tttccttcgg tgacctctcc ttcacgaccg atgagaaggc
    15721 ccccgaagaa gggagccgcg gcacgacccg attccactgt gacatcgtcg gcgccgaggg
    15781 gcgctcggga acactcaccg cattttacac agcccccggt tccatggggc tcaccgattc
    15841 cgaatggctc gatgcgatgc gtctgctggc cggtatcagc ggcttgggcg tcggagggta
    15901 cgtcacgtgc tcggggtaag taccgaagaa attcccgcca ggccctcgga aagccccgcg
    15961 aatctgctgg cgcggcctta ctggtaccgg gagttgcctc cgggaaccga tgtgcaccgg
    16021 ctcgacgacg ggctgttcgc cgccaccggg aacgccgccg tgcacgaggt gctcacccac
    16081 cccgggatcg tggccgagca cccgctcaag gccagcgccc gagccttcgg gcccaatgtg
    16141 ctcgacgccg acggccccgc ccaccgggcc tttcgcgccc tgctcgctcc ggtcctgtcc
    16201 ggggggcgga tcgcggagta caagcagacc ctgatgcccc ggctcatcga cgcgctcgtg
    16261 gacgccatcg ccgggaccga gacggacgac ttctacaact ccttcgcgca caaggtccct
    16321 tacggcatcg tctgcaccat cctcggcatc gacccggcct tggaggaccg cttccacaag
    16381 ctgacccgcc cgctggcccg gctcctggac tatcccaccg aggagaccgc ccagacccat
    16441 gccaacgtca gcgagctgct gaggttgatc gaggagcagc gcgcggtggg ggcggccgac
    16501 ccgcggtccc tcctggagac catcgagcgg acccgcgacc gcaagggcat caccctcacg
    16561 gacagcgaag tgcgttcgac ggccctgctg ttcttcctgg ccggcaccga gaccagcagc
    16621 gcgttcatca cctcgctggt gtactgcatg gggcgttcca tcttcgatct ggacgaactc
    16681 cgtgacgaag tggcccggga cgagttcatc gaagaggtcc tgcggctgta cccaccggtg
    16741 cagacgatcg tgcgcttcgc ggccgacgac gtgacggtcc acggcgtcga catcccacgg
    16801 cactcggcgg tgctcgcctc gatcgccggg gccaaccggg atccacggat cttcgaccat
    16861 cccgaccggt tcaccaccgg cagaagcctg aagggctcca tccccttcgc ggtcggggcg
    16921 cacgcctgcc cgggagcgat gctcgccaag gcggagttct cgctgctcgt cgagaggctc
    16981 gtcgagcgct gctcggaggt ggtcgtcacc cgcgaccaac tggccatgga gagccagtcg
    17041 ttcgcgcacc cggccggttt ctccgtgcat ttcaggacca agtaatcgca tgtcaagcaa
    17101 gagaaagagg aagccgtgga aggcaagata gcgctgctcc gtgagtggct cggcgacctg
    17161 cacgaggagc ccgtcagcat ccagggcgac acggacctcg tcgagtcggg cgtggtgacc
    17221 agcctccagt tcgtccagat ggtgatcgag atcgagcgcc tgcacggccg gaagctggac
    17281 ccgggcgtca tcaacatcga gtccatgcgg accctcgacg ccatcaacac gaccgtgttc
    17341 caggctgcct gatgggctcg gacacctccc gtgtcgcagt ggtctccggg acctcgtccg
    17401 ggatcggtgc ggcggtcgcg acggagttcc tgaaccggga ctacaccgtc gtcggcctgt
    17461 cccggcgggg aaaccccacg ctcgcgcagg agaaggggta cgtcgactgc gtggccgacc
    17521 tccgggacga ctcagccgtg cggtcggcgc tcgactcggt gtcgtccacg acggccggcg
    17581 gtgtgcgagc cgtggtgctc aactccggtg tctcgcccga cccggtcgac ctccgcaagc
    17641 tcgactggca ggtggcggcc gacgcgtacg agaacaatgt gcacaccgcc ctgagtctca
    17701 tccaggcgac ggcacctctg ctcgggcgag gcggcgacgg ctcgctcacc ttcgtcgggg
    17761 cgagcctggc caacggctac cagcccgacc ggtgggccta cgcggcgagc aaggccgcga
    17821 tgaccgccct gatgcgggcc tgctcggtcg agttcgccga cgacggcgtc gtggcgaacg
    17881 aggtgcgacc gggcccggtc gcaactgcca tgactttggc gggacttgac ggcgaggtga
    17941 gcgatcaggt catccgcgcc atcaacgagg gcttcggcac ggactggctc aaggcgccgc
    18001 gcaccgtggc cgaatggatc gtctccatcg ccgagttccc gtcgaacggg cccacgggcc
    18061 aggtcttcaa ctacagccgc aaggtgctgt gaccggcccc tcccccgcgt tcttcccctg
    18121 cgaacaaccc cctcttccgt cctccttcga aaggcacagc catgtccaac tacccttcgt
    18181 ccgagcagct tctcgacctg ttcaactggg cctcgcccgc catgctggtg acggacgccg
    18241 acggtctcgt cgtgctggcg aacaaggcgg ccgtggagct cctcgcggac cgggcgagct
    18301 ccggcaccaa gctcgccgac gccctgggca tcaacggcta caccgctctg ctcgcggccg
    18361 gtgagccggt ggagaacctg gacgccacct tcgtcaaccc cgacttcgcg tccggctacg
    18421 ccaacgtcgg tttcggcgag gtcgagggca gcacctacgg cttctgggcg ctgcgccccg
    18481 tcaccacgca cccgaccccc tcctcgcagg ccggtgaggg caactccacc gcgcaggcgt
    18541 ggatcagcca ggtcgaccgg agcaacgcgg cgtacacccc cgtgggcgaa gacgccgtca
    18601 agttcatccg ggcgtactac gacaactgcc cggtcgccat ccacctcatc gaggaggacg
    18661 gcaccgtcgc ccacgccaac tggaaggaca tcgcgatcgt cggtgccagc gagcagccgg
    18721 acacctacgt cggtcaccac atccgtcaca tctacgccga ccaggaggtc gtggaggact
    18781 tcctcggccg ctggggcgag gacgctccga tcatcgactt ccgtgcggac ttcctcaaca
    18841 agggcgagcg ggtgcccgtg gtgatcttct ccaccgccaa ggtcgaggac aacaagctca
    18901 agaacacccg ctgcttcgtc ttcccggaca gccacccgga ccgcaagcgg gacaaggtca
    18961 aggcgctgga cctcaacttc tgagcagcgg caccacacca ccaccccctt tcgctgttcg
    19021 ccgcgaaacc cgggctccgg gcggccactg gtcgccgggg cccggccctg ccccggaacc
    19081 cctgactcat ctggagcaca ccatggctga caccaccgcc gggcggggcc gctggctcac
    19141 cggctgggat cccgaggacg aggacgcctg ggacaggggc ggcgaccgca tcgcccgccg
    19201 caacctgatc ctctccgtcc tcgccgagca catcggcttc tcggtgtgga ccctgtggtc
    19261 cgtgctcgtc ctgttcatgt cccccgccat cggcctcggt ttcaacccgg gtgagaagtt
    19321 cctcctggtc gccaccccga ccgtcgtcgg cgcgctgctg cgcctgccgt acagctacgc
    19381 ggtgacccgg ttcggcgggc gcaactggac cgtgttcgcc accgcgatcc tgctggtgcc
    19441 cgcgctgctc gccctgtact tcgtgcagcg ccccggcacc ccgctgtggg tgttcctggt
    19501 gatcggcgcc acggccggcg tcggcggcgg caacttcgcc tcctcgatga cgaacatcac
    19561 cgcgttctac ccgcaacgcc atcagggctg ggccctcggg ctcaacgcgg gcggcggcaa
    19621 cctcggcgtg gcggcggtcc aactcgtcgg cctcgcggtc atctccctcg ccggcaacac
    19681 ccacccctcc tatgtcgcgg ccgtctatct gccgctgatc gtggtcgtgg ccctgctcgc
    19741 cgcgtggaag atggacaacg tcgacgccgt acgggccgaa cccggcgccc agcgcgaggc
    19801 ggcccggcac cgtgacacct ggtggatctc cctcctgtac atcggcacgt tcggctcgtt
    19861 catcggctac ggcttcgcct tcggtctcgt cctacagaac gagttcggct ccaccccgct
    19921 ccaggcggtc ggctacacct tcctcggccc gctgctcggg tccttctcac gcccgctggg
    19981 cggcaagctg gccgaccgca agggcggcgc acgggtctcg ttgtggaact tcctcggcat
    20041 gggcgccggc accgtcgtgc tcatcgtcgc cgcgggcctg cactccttcg cgctgttcat
    20101 cggggggttc accgcgctgt tcgtgctcag tggcctcggc aacgggtcga cgtacaagat
    20161 gatcccggcg gtgttcgcga agaaggccga ggacgagatc actcgcggcc acgacgcgag
    20221 cggggccttt gcccgcgccc gccggctgtc gggcgcggtc atcgcgatcg ccggtgcggt
    20281 cggcgcgctc ggcggtgccg ccatcaacct cgcgttcaag ctgtcgtacg cgaacggctc
    20341 cagctccggc atcccggcct tcgtggtctt cctcgcctac tacgcgctgt gcgtcgccat
    20401 catccgcttc gtctatctgc gcccttctgc cacgggcggc gggcacacca cgaagagcgt
    20461 caaggaagcc agccatgtct gaactcggcc cgccactgcg ggaggtggcg acccactgcc
    20521 cgtactgcgc gttgcagtgc ggtacgcgcc ttgccggtga ccgggagacc ggcgtggtgg
    20581 tgcggcccga cgatttcccg gtcaaccggg gccggctgtg ccagaagggg tggaccgccc
    20641 ccgcggtcct gtccgccacc gaccggctga cccggccgct ggtccgccgc cgcgacggcc
    20701 ggctcgccga ggcgtcctgg gacgtcgcgc tggagagggt ggccggggag ctgcgccgca
    20761 tccgcgccga gcacggcccg gacggtgtgg cggtcttcgg tggcggcggg ctcaccaacg
    20821 agaaggcgta tctgctgggt aagttcgccc gtctcgcgct ggggaccagc cagatcgact
    20881 acaacggccg gttctgcatg tcgtcggcgg ccgcggcggg caacgcggcg ttcggcgtgg
    20941 accggggtct gccgttcccg gtcaccgacc tccagggtgc gcggacggta ctgctggcgg
    21001 gtgcgaacgt cgccgagacg atgccgccgc tgatgcagca cctcgacggg gccgagctga
    21061 tcgtcatgga tccgcgccgg accgccagcg cccagcgggc ggcgctgcac ctgcaacccg
    21121 cgccgggcac cgatctggcg ctcgcgctcg gcctgttcca catcgccgcc gtggacggtc
    21181 tgctcgaccg gaactacatc caggaccgca cccggggctt cgaagccgcg ctgcggcgcg
    21241 cgatggactg gtggcccgag cgggtggaag ccgtcacggg catccccgcg agcgaccagc
    21301 gcgccgccgt acacatgctc gcgagggcgg gcggcgccta tgtgctgacg ggccgcggag
    21361 tggagcagca cagcacgggc accgacacgg tggcgggctt catcaacctc gccctcgccc
    21421 tcggcctgcc gggccgcgcg ggcagcggat acgggtgtct gaccgggcag ggcaacggtc
    21481 aaggcggccg cgagcacggg cagaaggccg accagttgcc cggctatcgg tccatcaccg
    21541 atccggcggc gcgggcccat gtcgccgccg tgtggggcgt ggcgccgcaa gagctgccgg
    21601 gtcccggacg cagcgcctat gaactcctgg acgccctggg cggcgaccgg ggcccgcggg
    21661 cactgctggt gttcgggtcg aacccggccg tctcggcccc gcactccaca cgggtgaccg
    21721 agcggctcgc agccctcgat ctgctggtgg tggccgactt cgtgccgtcc gagacggccc
    21781 gcctggccga tgtggtgctg cccgtcaccc agtgggccga ggaggagggc accctgacga
    21841 atctggaggg ccgggtgctg cgccgccgcg cgcggctttc gccgccgggg caggtgcgca
    21901 gcgacctcca ggtcctgcac gaactcgcgg tacgcctggg cgagcccgcg agccgctacc
    21961 ccacggtccc gcaggaggtc ttcgacgaac tgcgcgccgc ctcccggggc ggcagggccg
    22021 actacgcggg tatctcctac gagcgcctcg acgccgggga gagcctgcac tggccctgcc
    22081 cggacacccc cgacccccac ccgggcacgc cccggctctt cctcgaccgg ttcgaacacc
    22141 ccgacggcag ggcgcggttc gccgccgtgg accaccaggg cccggcggag gagctcaacc
    22201 cccactaccc gctccacgcg acgaccggca gggtcctggc gcactaccag tcgggtgcgc
    22261 agacccgccg cgtggccgaa ctcaacgacg ccgtgccggg gcccttcgtc gagatgcacc
    22321 ccgacaccgc gctccggtcc ggggtgtccg acgcgggcct cgcccgggtc atctccgcgc
    22381 gcggcagcat gacggcccgc gtccgggtcg atccgacgat gcgtctggac accgtgttcg
    22441 cgcccttcca ctttcccggc gagggccggg ccaacctgtt cacccatccg gcccttgacc
    22501 cgcacagcgg gatgccctcg ttcaaggtgt gcgccgtgcg ggtcgagccc gtgtcaggag
    22561 tcgcgccgtg aaccgtgtcc tcgtcctggg caacggcccg acagcccatc acttcgccga
    22621 ccggctgcgc cagcacgggc acgaagggcc cctcaccctc ctggggaccg aacccggggc
    22681 cacccaccac caggcgttcc tcgacgccct gctcgcccct gccgaccttc aactgccgcc
    22741 cccgcccggc ctcgacgtcc gcaccgacac ccgggtggtc gccatcgacc gcgcgcagcg
    22801 ccgggtgcgg gcgctggtcg gcgaggccga gaccgtcttc ccgtacgaca cgctggtcct
    22861 cgccctggag gcgcgccccc tcctcccccg ccttcccggc atcgccgccc ccgacgggcg
    22921 cctcggcccg ggggtcgtcg tcccgcggac cgcggccgac cgcgagcgga tcagcggcga
    22981 gagcgccgtc gtgctcggcg gcgggccgca ggccgtggag attgcgagcg cgctggccgc
    23041 tcggggtacc aggaccacgc tggtgtgcga gcgcccccac cccttggagg agcgcctggg
    23101 tgagacctgt gccgcctggc tcgccgagcg gctggagcgg gccggggtca ccgtgctcgg
    23161 cggccgcacc gccgtgcggc gcaccccggg ccggctgcac ctcgatgacg gaaccgtcct
    23221 gccggccgac accctggtgc tgtgtcccag cgtcgtgcct gaccttgaac tcgccgtcgc
    23281 agcacgtctt ttgacggaca gtgggatcgt tgtcgacgcc cagctacgca gcagcgaccc
    23341 ccacgtccac gccatcggcc ccggcgtcga gcacgagggg cgggcgacgg agggccccgc
    23401 tgccgctctg gagcaggccg acaccctcgc gcggatcctc accgggcgag gcggtaccta
    23461 ccgggccgca ccgcccgtgc tccgactgcg catccgcgcg gcggacgtgt gccacatagg
    23521 aacgccggcc gacttcgacg gcccggacac ccgcctcgtc accctcaccg acccgaagga
    23581 gcgacggtac gcccggctcg cgctgcgggg cgaacgcgtc gtcggcgccg tcctgttcgg
    23641 ccttccgggg gccatcgccc cgatcgtccg cagtcaccgg ctcagccaac aactcccgta
    23701 cgacctcgtg ggattgctcc tgggatggcc gcccagatcc gcgtccgacg cggccgagcc
    23761 cgaggcccgg tcgctggtgt gcctctgcaa cagcgttacg gagacggccc tgcgccaggc
    23821 ctggcaggcg ggcgcccgca cggtcccggc gctcgccacg gcgacccgcg tcacaacggg
    23881 gtgcggcggc tgcggtgagc gcgtacggga actgtgcgcg gcatgggcac ctgggcggca
    23941 taccgaactg aaggatgcgg cgtgacccgg agactcgtcg tcgtcggcca tggaatggtc
    24001 gggcatcaac tcgtggaccg cttgacgtcg ttggacaccg agggcacctg gcgcatcgtg
    24061 gttctgggtg aggagcgcca cctcgcctac gaccgtgtct ccctctcctc gtatctggac
    24121 ggcaagagca aggacgacct gaccatcgcc gggccggtcc tccgtcacga cgccagggtg
    24181 gaggtgcgcc tcgcctgccc ggcagtgtcc gtcgaccgca cgtcccgtac ggtcacaacc
    24241 gccgacggcg acgacatcgc gtacgacgcc ctggtactgg cctgcggctc ccgcccgttc
    24301 gtccccccgg tcccggggca cgacctcgtg gggtgtttcg tctaccgcac cttcgacgac
    24361 ctcgacgcca ttcgcgcggc cgcccgcgcc ggccggcccg gcctggtgat cggcggtggt
    24421 ctcctaggct tggaagcggc caacgccctg cgtctgctgg ggatgcatcc gcacatcgtg
    24481 gagacggcgc cgcatttgat gtcggcccag ctcgacccgg gcgcggcgcg cgtgctccac
    24541 cagcaggcca ccgagctcgg tctccggctg cactgctcga ccgcgaccgc gtcgatcgag
    24601 gcccgccccg acggcacggt gcgcgcggtg cggctctccg acggaaccgt tgtggagacg
    24661 gagctggtgg tcttcgccgc cgggatccgc ccccgcgacg agctggccgt atcggcgggt
    24721 ctggcactcg gggagcgcgg cggcatcgcg gtcgacgacc ggtgccgtac gcgggacggg
    24781 cgcgtctggg cgatcggtga atgcgccgcc gtcgaggggc gctgccacgg tctggtcgcc
    24841 ccgggctacc gcatggcgga caacgtggcg cgtcagctga tgggccagga caccgagccc
    24901 ttcgacggtt cggacaccgc caccacgctg aaactcctcg gtgtgaacgt cgcctccttc
    24961 ggcgccaccc gccctgcgga tggccaggcc ctcgaagtcg tcttcgccca gggcagcacc
    25021 cggtacgcca agttcttcct gcggcgggac agcggagcgc tcctcggtgg aatggtcgcc
    25081 ggaggcaccg cctccccgct cgccctcgcg tccttcctcg gccgacgacc gcccgcggac
    25141 ctggaacagc tcctcgctcc cgacctcccc ttccttccat gacggccctt tcgagactcg
    25201 aaacaccgct ctgaaggagt ctgcgttgaa ggcgaccgga ttcaggggcg ggtcccggtt
    25261 gcggaatccg tcgtgggcgg gtcgagcagc caggtcaccg gccgtgccgg gtccgggtcg
    25321 tagtggcagc acgcgcccgt gtggacggtg tcgcgcagca gccgggcgag ggcggcgtcg
    25381 tgctgctgga tgcggtcgag ggcggcggcg a
//
