LOCUS       NZ_CP032543            11368 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7081871
            Orig. end                         :: 7093239
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="31"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            244..1302
                     /locus_tag="D6270_RS31680"
     CDS             244..1302
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955794.1"
                     /locus_tag="D6270_RS31680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_109162288.1"
                     /transl_table=11
                     /translation="MSVMEAAPAPPRPVWRSPGVRMGALAVLVCAAACADLFAGRGVTG
                     EGVRAVLLGGGGDPMAEHIVLQLRLPRLLVALVAGASLGVAGLVLQSALRNPLAGPEVT
                     GVTPGAVLGAVAATGLGLAGWGSPTAVVVAACLGGFAGAGLLWLLAGREKGDPEQTAVY
                     GVLVSAVLAGLTAVVLLVAPGELGSVVQWLIGSTEGRVWQHWHLLWPWALVWGAAAWLL
                     SAPLTLLRCGDEQASAAGLNPGRGRAAALVCAVALTAGAVSAVGALGFVGLLVPHLALA
                     VFGADLRIALPGAALLGAVVVCGADAAAQLLSRLLVVALDADRLTLPVGALTTFVGAGL
                     LLVVARRRTDER"
     gene            1320..2228
                     /locus_tag="D6270_RS31685"
     CDS             1320..2228
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613002.1"
                     /locus_tag="D6270_RS31685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_225977010.1"
                     /transl_table=11
                     /translation="MAARTRDVTTDGGRGVAEAADGRNDAARAPDVVRAERLSFGYPGR
                     EVLRGIDLGIGAGELVALIGLNGCGKSTFLKLAAGLLTPSGGRVLLEGDDAAHLPRRAA
                     ARRVALLHQSAPAVPALTVRQLVRQGRYAARGPLGMLRDGDDEVTARALADVGVTGWAD
                     RPVDALSGGERQRVRLAMALAQDAPVLFLDEPTTYLDLRHQLEVLQTVVRLRGERRLTV
                     VMVLHDLNHAARFADRIVALREGRIAADGPPGEVVTERLLAEVLGVQGRVGTDAEGGWP
                     VCYPDHPLDPLQLLRNENHIH"
     gene            2296..2430
                     /gene="amiA"
                     /locus_tag="D6270_RS33750"
     CDS             2296..2430
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="D6270_RS33750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_015613003.1"
                     /transl_table=11
                     /translation="MEHNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTADEK"
     gene            2558..3418
                     /locus_tag="D6270_RS31690"
     CDS             2558..3418
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452727.1"
                     /locus_tag="D6270_RS31690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109162286.1"
                     /transl_table=11
                     /translation="MNRSRLAPGAGIVTVPGGRPVLRTSDGEFLRIDTGRVGTEELVGR
                     LAPGEGAPVESAELDDLVTAFEEAGHAVTEPRRPPLTGRTVHLLGDPVLTGPLSRFAAA
                     EGAEVRPATADGVAALAGERDTAVVWCLDSPVPEGLWDAADRLPAGHTAWLRCHREGAH
                     AWIEPLASAPGDVTAAHVRLRRLAATAAHRELAAYWAGHRTPDTGPHPTQASAALIAAL
                     LTADLIAWANGEPPRGATLPARRRLRRVDLRDLTVTEHPALPVPEVAPLPAATARRSPA
                     ARVNA"
     gene            3481..5004
                     /locus_tag="D6270_RS31695"
     CDS             3481..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512968.1"
                     /locus_tag="D6270_RS31695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_109167194.1"
                     /transl_table=11
                     /translation="MYIPAPDGTPLATDLHLPDTPGPHPAVVIRTPYGRAAHRAELRGW
                     AAHGFAALAQDVRGRHGSPGPWHPYREHEEGDGAATMAWVREQAWSGGGPVVAAGASYA
                     AHCALAAALGPPGDGRPDAVIAAVPALGLAETAREPGGPERLWARAGWWAAHGDRPDSA
                     PGALTRALAEDPRLLEHLPLTRLPDRLGRALPSWPELWGACPRGRTVLRGSASPLPLLA
                     VGGTRDPFAEDTMALWSGWGGPARLLLGPWGHRLTADRTEIAADRVNLGALYVRWARAA
                     LAGRLEPERRGVITLGGSGRWHGVRGGDAQGPTDSSTRTTTWPFDAPSGLRLLHGAEFT
                     ADPARPVRSDDLSVPADATPADRCLLLSPPLPRPLDLLGPATARLHATADTPAADWAVR
                     VTALDPAGRAEPLAFGIVRRTDPPGETVEITVPLGTLGRRLPAGTRLRTEIAGHHFPAH
                     ARNPHTGENPVTATRLAPSRRAVTARGSALHLTVVARRRYVEPVPEICR"
     gene            5001..6368
                     /locus_tag="D6270_RS31700"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="D6270_RS31700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_204117024.1"
                     /sec_met_domain="YcaO (E-value: 2.6e-43, bitscore: 147.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTLPIEALVDPVCGVIRGVEPVQHPEGAPPRYTAMTAEVADAR
                     RLGAWPADRVSLGTTFGDPEGAWIAAVAEAVERYCGNRVPPPGHPDAPRRATAAELEAE
                     GLRLYGPGAVPSYASWQHERPGFPYAQLTPDTPALWTRATENGRPCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTEDMAGAELDVHIVEMPSEFAPCMAALVHDPRRGIHAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVHRSVEAGLFARGLYLDHRSDRRYLDDCGPQFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPVWGTVPVTEVAPGSRSGLDAALRAGGHRVITVDLTTEDIAET
                     ALRVARVLVSGLVPNAPAAFGYFGCARLAEAALARGWRTDVPTGPADFTLAPPPHM"
     gene            6383..7741
                     /locus_tag="D6270_RS31705"
     CDS             6383..7741
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613008.1"
                     /locus_tag="D6270_RS31705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase"
                     /protein_id="WP_109162284.1"
                     /transl_table=11
                     /translation="MTQAPPGLLRRALADARSLRVPPTVPYLPERVFPWGGPALSLAGA
                     GGGVDLDRFLRLSLAAPDGSTTGRLRPVASAGALHPVRAHLLVGPGCTLPPGRYAYDPR
                     THRAHPRGPAPADAPPGAVVVLTVTAARTVAHYGHRAWPLLLLDAGHAAAALALAAAPH
                     GARVCLDADGAQLSAAAGLPGPAEWSERWPGTEPELPILAMWLSTAHQPVPATGPSAAW
                     AALPHATAPTPQPDAASAPSAELAHTRQVLEHLTAAPTHPAPTWHPARRRPAPLTNDTL
                     RTRRSAPTSDLAHPPAPDPLARILTTAEEARPDGPAWAAAIGGEAPALLTTAGVLAFGD
                     ARPTLARWAAGQRWIGTAGAVLVAHGCPADASPALIRGSHLAAGYAAGVAQAHATALGL
                     RSRPIGSWQQADLGAALADAPGHDWIVHGLALAGPADPAPSAPPPPSGKEERP"
     gene            7738..9475
                     /locus_tag="D6270_RS33875"
                     /pseudo=""
     CDS             7738..9475
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964397.1"
                     /locus_tag="D6270_RS33875"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MMLHPELLRAARSARRPLGRATALLAAVTLTHLAQAVLLAVVLSR
                     IAQGDTSGLAPLLLSVLAVVLVRAVLGRAQRLTAVTAGAAVRIRLRDTLLARLGELGPT
                     AITGARAGAVRATLVDGVEGVDAYVSRYLPQALITAAVPPLLLVAVALIEPYAALALGL
                     ALLLALLGPRGWDRLLARRGKDHWDSYEALAADYLEALQGMATLRAAGAVGRVREKLEK
                     RSAALHRATVAKLRVSLADTGLTDLAVQGGTAAAVLVACSSAATGRTAATGTYLLLMLA
                     SECFRPIRDLSREWHAGYLGVSAADGIAALRTADPAVADRGGRSPAGTPRPHPLRGRPL
                     HPPRGGPSRPRRHHLHRTRRAHDGDRRALGCRKVHPAEPAAAPARPRQRARHDRRDRDR
                     RVHPRLAAAGDRRRLAGDVPLPRHDRREPARRPPRRHRPTAARRRPGGGHRPGDHRLPP
                     GVRHPRRRTRRHALRRPAPTPRPRPRPAGRHTGPDPGRGHQRGGRARRGPDRTGVARGE
                     PGPDLSRRRPPTRRRTPRRPHRRPRRRPGRGVRRPQRTAGGRRRVRLARRRGPHRPGGT
                     RRM"
ORIGIN
        1 gctcgtccgg tccgcgctgt gcggggcggt cgtggtgctc tgcgcggacc agcccgcacg
       61 gctggcactc gcaccggtcg agacgcccgt cggggcgtgg acggccctgg tcggggtgcc
      121 ggtcggggtg gtgctgctga agcgggggcg gcgggcggcg aaggtccggg ggcccatcgg
      181 gcctgtcctg ccggttcgga gcgggccggt cgagtcgtca cctctcctgc ggaaggcgga
      241 gcgatgagcg tcatggaagc ggcgcccgcg ccaccccggc cggtgtggcg ctcgcccggc
      301 gtccggatgg gagccttggc ggtgctcgtc tgcgccgccg cctgcgcgga cctgttcgcg
      361 gggcggggcg tcaccggcga gggggtacgg gccgtactcc tcggcggggg cggcgacccg
      421 atggccgagc acatcgttct ccaactccgg cttccgcggc tgctggtggc gctggtcgcc
      481 ggggcgagcc tgggtgtcgc cgggctcgtc ctccagtcgg ccctgcgcaa tccgctggcc
      541 gggcccgagg tcaccggggt cacccccggc gcggtcctcg gcgcggtcgc cgccaccggt
      601 ctcggcctgg ccggctgggg ctccccgacg gccgtcgtcg tggcggcctg cctcggcggg
      661 ttcgcgggcg cggggctgct gtggctgctc gcgggacggg agaagggcga ccccgagcag
      721 accgccgtgt acggggtcct ggtgtcggcg gtcctcgccg gactcaccgc cgtcgtcctc
      781 ctggttgccc cgggtgaact cggcagcgtg gtccagtggt tgatcggctc caccgagggc
      841 cgtgtctggc agcactggca cctgctctgg ccgtgggcgc tggtgtgggg tgccgccgcg
      901 tggctgctct ccgcgccgct gaccctgctg cgctgcggcg acgaacaggc ctctgccgcc
      961 gggctgaacc cggggcgcgg ccgcgccgcc gcactcgtgt gcgccgtggc gctgacggcg
     1021 ggagcggtct ccgccgtggg ggcgctcggc ttcgtgggcc tgctggtgcc gcatctggcg
     1081 ctggccgtct tcggggccga cctgcgcatc gcccttcccg gggccgcgct gctcggtgcg
     1141 gtggtggtgt gcggggcgga cgcggcggcc caactgctct cccggctcct ggtggtggcc
     1201 ctcgacgcgg accggctcac cctgccggtc ggcgcgctga ccaccttcgt cggggccggg
     1261 ctgctgctgg tcgtggcgcg gcgacggacg gacgaacgat gacggggagg aggccggaga
     1321 tggcagcacg tacgagagat gtcacgacgg acgggggcag gggcgtggcg gaggcagcgg
     1381 acgggaggaa cgacgcggcg cgagcaccgg acgtggtccg ggcggaacgg ctgagcttcg
     1441 gctatccggg gcgtgaggtg ctgcgcggga tcgacctggg catcggagcg ggcgaactcg
     1501 tggccctcat cggcctgaac ggctgcggca agagcacctt cctcaagctc gccgccggcc
     1561 tgctcactcc gagcggtggc cgggtcctgc tcgaagggga cgacgcggcg cacctgccca
     1621 gacgggccgc cgcccgccgc gtggccctgc tccaccagtc ggccccggcc gtaccggcgc
     1681 tgacggtacg gcagttggtc cgccagggcc gttacgccgc ccgggggccg ctcggcatgc
     1741 tgcgggacgg cgacgacgag gtgacggccc gggccttggc cgatgtcggc gtcaccggct
     1801 gggcggaccg gccggtggac gcgctgtcgg gcggtgaacg gcagcgggtg cggctggcca
     1861 tggcgctggc gcaggatgcc ccggtcctct tcctggacga gcccaccacg tatctggatc
     1921 tgcggcacca actggaggtg ctccagacgg tcgtacggct gcgcggtgag cggcggctca
     1981 cggtggtgat ggtgctgcac gacctcaacc acgcggcgcg gttcgcggac cggatcgtcg
     2041 cgctgcgcga ggggcgcatc gccgccgacg gcccgcccgg agaggtggtc acggagcggc
     2101 tgctggccga agtgctggga gttcaggggc gggtggggac cgatgccgag ggcggctggc
     2161 ccgtctgtta cccagatcac cctctcgatc cgctccagct attgcggaat gaaaatcata
     2221 ttcattagtg tctgtggtgc ggcagagaac agcgtcgcaa ccatcaccaa ccgatccgaa
     2281 tggaggcttc aactcatgga gcacaacaag gtgttcagcc cgatcgcgga ccagggccag
     2341 ctcgcccacc tctccgccac ccactcgaac gccctcgtcg agaacccctt cgacgacgcc
     2401 gtcgaggccg acaccgcgga cgagaagtaa gcggaacctg ccgctgaggc aggctcccgt
     2461 tcctcgcgtg gcgggcccgt ccgggcgaaa ccccggacgg gcccgtcccg ttcgcaccgc
     2521 acgctcattc ccgtacgacg cccatcggag gctccccgtg aaccgcagtc gactcgcccc
     2581 cggcgccggg atcgtcaccg tccccggtgg ccggcccgtg ctccgcacct ccgacgggga
     2641 gttcctccgc atcgacaccg gacgcgtcgg caccgaagag ctggtcggcc gactggcacc
     2701 gggagagggg gcgcctgtgg agtcagccga actcgacgac ctggtaacgg cgttcgagga
     2761 ggccgggcac gcggtgaccg aaccccgccg ccctccgctc accggccgga ccgtccatct
     2821 cctgggtgac cccgtactca ccgggccgct gtcccgcttc gccgcggcgg aaggggccga
     2881 ggtccgtccc gccaccgccg acggcgtggc cgcactcgcg ggggagcggg acaccgccgt
     2941 ggtctggtgt ctcgactcac ccgtaccgga agggctgtgg gacgcggccg accggctgcc
     3001 cgccgggcac accgcctggc tccgctgcca tcgcgaaggc gcccacgcct ggatcgaacc
     3061 cctcgcctcg gcccccggcg atgtcaccgc cgcccatgtc cgcctgcgca gactcgcggc
     3121 gaccgccgcc caccgcgaac tcgccgccta ctgggccggc caccgcaccc ccgacaccgg
     3181 accccatccc acccaggcgt ccgccgccct gatcgccgca ctgctcaccg ccgacctgat
     3241 cgcctgggcg aacggcgaac cgccccgagg ggccaccctc cccgcccgcc gccgactgcg
     3301 ccgggtcgat ctgcgcgatc tgacggtgac cgagcacccc gcgctcccgg tcccggaggt
     3361 cgccccgctg ccggccgcca cggcacgaag gtcacctgcc gcgcgggtga acgcgtgaac
     3421 gccgtgggcg gcggcgtggg cacggcccac cgcgaggacg gccgcccgaa cacctcaacc
     3481 gtgtacatcc ccgcccccga cggcacccct ctcgccaccg atctccacct cccggacacg
     3541 ccgggtcccc accccgccgt cgtgatccgc accccctacg gccgcgccgc ccaccgtgcc
     3601 gagctgcgcg gctgggcggc ccacgggttc gcggccctcg cccaggacgt acgcggccgg
     3661 cacggctcgc cgggaccgtg gcacccctac cgggagcacg aggagggcga cggtgccgcg
     3721 accatggcct gggtacgcga gcaggcgtgg agcggcggcg gcccggtcgt cgccgcaggc
     3781 gcctcctacg ccgcccactg cgccctcgcc gccgcgctcg gcccgcccgg cgacggccgg
     3841 ccggacgccg tcatcgccgc cgtccccgcc ctcggcctcg ccgagaccgc ccgcgaaccc
     3901 ggggggcccg aacggctctg ggcccgcgcc ggctggtggg ccgcgcacgg cgaccgcccc
     3961 gactcggccc ccggcgcgct gacccgcgcc ctggccgagg acccccgcct gctggagcac
     4021 ctcccgctca cccggctgcc cgaccgcctg ggccgcgccc tgccctcctg gcccgagctc
     4081 tggggcgcct gcccccgtgg ccggaccgtg ctgcggggct ccgcctcccc gctcccgctt
     4141 ctcgccgtgg gcggcacccg cgatcccttc gccgaggaca ccatggcgct gtggtccggc
     4201 tggggcggcc ccgcccgcct gctgctcggg ccctggggcc accgcctcac cgccgaccgg
     4261 accgagatcg cagccgaccg tgtcaacctc ggtgcgctgt acgtacggtg ggcccgcgcc
     4321 gcactcgccg gacggctgga acccgagcgg cgcggggtca tcaccctcgg tggcagcggc
     4381 cgttggcacg gcgtacgggg aggtgacgcg cagggaccga cggactcctc gacgcgcacc
     4441 accacctggc ccttcgacgc tccatccggc ctacgtcttc tgcacggtgc cgagttcacc
     4501 gccgacccgg cccgcccggt ccgctccgac gacctgtccg tacccgccga cgccaccccc
     4561 gccgatcgct gcctcctcct ctccccgccc ctgccccgcc ccctcgacct cctcgggccc
     4621 gccaccgccc ggctccacgc caccgccgac actcccgccg ccgactgggc cgtacgcgtc
     4681 accgccctcg acccggccgg ccgtgcggag ccgctcgcgt tcgggatcgt ccggcgcacc
     4741 gacccgcccg gggagaccgt ggagatcacc gtgcccctcg gcaccctggg ccgccggctg
     4801 cccgccggga cgaggctccg cacggagatc gccggacacc acttcccggc ccacgcccgc
     4861 aacccgcaca ccggcgagaa cccggtgacc gccacccgcc tcgccccgtc ccgcagagcc
     4921 gtcacggccc ggggcagcgc cctgcacctg accgtcgtcg cccggcgtcg ttacgtcgag
     4981 cccgtaccgg agatatgccg ttgaccagca ccctgcccat cgaagccctg gtcgaccccg
     5041 tctgcggggt gatccggggt gtggagcccg tccaacaccc ggaaggcgcg ccgccccgct
     5101 acaccgcgat gaccgccgag gtcgccgacg cccgccgcct cggcgcctgg cccgccgacc
     5161 gggtctcgct cggcaccacc ttcggggacc ccgagggcgc ctggatcgcc gccgtcgccg
     5221 aggccgtgga acggtactgc ggcaaccgcg tcccgccgcc cggtcacccc gacgcaccgc
     5281 gcagggccac ggccgccgag ctggaggcgg agggactgcg gctgtacgga cccggggcgg
     5341 tgccctcgta cgcctcatgg cagcacgagc gcccaggatt cccgtacgcc caactcaccc
     5401 ccgacacacc ggcactgtgg acacgggcca ccgagaacgg ccgaccctgc tgggcccccg
     5461 tagcgctcac ccacctcaac tggcgccagg gcgagctgcg ttcactgcct cgaacccacc
     5521 acctcaacta cgcgggcata gccaccggcc aaggcctcga cgacgccgtt gagcgagggc
     5581 tgctcgaagt cgtggagcgc gacgccctgg agctgtggtg gcacctggac gggcccaccc
     5641 ggggcatcga cccggcgagc gtgccgggcc tcaccgagga catggcgggc gccgaactgg
     5701 acgtccacat cgtggagatg ccctccgagt tcgccccttg catggccgcc ctggtccacg
     5761 acccccggcg cgggatccac gccgccggct tcgcctgccg gtacgacccg gcggaggcgg
     5821 cccgcaaagc ggtgctggag gcggtgcaca cctgggtgtt cacgcaaggg gcggtggacg
     5881 ccgacggctg ggtccaccgt tcggtggagg ccggtctctt cgcccggggc ctctacctgg
     5941 accaccggtc cgaccggcgc tatctcgacg actgcggacc gcagttcgcc gccgtacggg
     6001 acctcggcgc ccatgtccag gtctggctgg acgaccggat ggccccgctg gcccgccgct
     6061 tcaccgaacc cgtctggggc accgtccccg tcaccgaggt cgctcccggc agccgctccg
     6121 gcctggacgc ggccctccgc gccggcggcc accgcgtgat caccgtggac ctcacgaccg
     6181 aggacatcgc cgagaccgca ctgcgcgtcg cccgtgtcct ggtctccggt ctggtcccca
     6241 acgctcccgc ggccttcggc tacttcggct gcgcgcgcct cgccgaggcc gcgctcgccc
     6301 ggggctggcg gaccgacgtc cccactggcc cggcggactt caccctcgca ccgccacccc
     6361 acatgtgatg gagcgcgttc ccatgaccca ggctcctccc ggcctcctgc gccgagccct
     6421 ggccgacgcc aggtcactcc gtgtgccgcc caccgtgccg tacctgccgg agcgtgtgtt
     6481 cccgtggggc ggcccggcgc tctctttggc gggggccggt ggaggggtgg acctggatcg
     6541 attcctgcgg ctgtcgctcg ccgcccccga cgggtcgacg acgggtcggc tgcggcccgt
     6601 cgcctcggcg ggcgcgctcc atcccgtacg ggcgcacctg ctcgtcggcc ccggctgcac
     6661 gctgccgccc gggcggtatg cctacgaccc gcgcacccac cgcgcccatc cgcgcggccc
     6721 ggcccccgcc gacgcacccc cgggggcggt cgtcgtcctc accgtcacgg cggcccgtac
     6781 cgtcgcgcac tacgggcacc gcgcctggcc gctgctcctg ctggacgcgg gccacgccgc
     6841 agccgccctg gcgctcgccg ccgcaccgca cggcgcacgg gtctgcctcg acgcggacgg
     6901 cgcccagctc tccgcggcgg cggggctgcc cggaccggct gagtggagcg agcggtggcc
     6961 cggaacggag cccgaactcc cgatcctggc catgtggttg tccacagctc accagccggt
     7021 ccccgcaact ggcccgtcgg ccgcctgggc tgccctgccc cacgccaccg ccccgacgcc
     7081 gcaacccgat gccgcgtccg cgccatctgc tgaactcgcg cacacccggc aagtgctgga
     7141 acacctgaca gcggccccca cccaccccgc tcccacctgg caccccgccc gacgccgacc
     7201 cgccccgctg acaaacgaca ccctccgtac gcgaaggagc gcgcccactt ccgacctggc
     7261 gcacccgccc gccccggacc cgctcgcccg gatcctgacc accgccgagg aggcccggcc
     7321 ggacggaccc gcctgggccg cggcgatcgg cggcgaggct ccggcgctcc tcaccaccgc
     7381 cggggtcctc gccttcggtg acgcccgccc caccctcgcc cgctgggcgg cgggccagcg
     7441 gtggatcggc acggcgggcg cggtgctggt tgcccacggc tgccccgccg acgcctcgcc
     7501 cgccctgatc cgcggcagcc acctcgccgc cggttacgcc gccggggtcg cccaggccca
     7561 cgcgaccgcg ctcggcctcc gctcgcgccc catcggctcc tggcaacagg ccgacctcgg
     7621 tgccgcgctc gccgacgccc ccggacacga ctggatcgtc cacggcctgg ccctcgccgg
     7681 gccggccgat cccgcaccat ccgccccacc gcccccgtcg ggcaaggaag aacgcccatg
     7741 atgctccacc ccgaactcct gcgcgccgcc cggtctgccc gccgtcccct cggccgggcc
     7801 accgcgctcc tcgccgccgt caccctcacc cacctcgccc aggccgtact gctcgccgtc
     7861 gtcctctcgc ggatcgccca gggagacacg tccggcctgg cgccgctcct cctctccgtg
     7921 ctcgccgtcg tccttgtccg cgccgtgctg ggccgcgccc agcggctgac cgccgtcacg
     7981 gcgggagccg ccgtccggat ccggctccgc gacaccctgc tggcccgcct cggcgaactc
     8041 gggcccaccg cgatcaccgg cgcgcgggcc ggagccgtac gcgccacgct cgtggacggc
     8101 gtcgaaggag tggacgcgta cgtctcccgc tacctcccgc aggcgctgat caccgccgcc
     8161 gtcccgccgc tcctgctcgt cgccgtagcg ctcatagagc cgtacgccgc cctcgccctg
     8221 gggctcgccc tgctgctcgc gctcttgggg ccgcgtggat gggaccggct gctcgcccgg
     8281 cggggcaagg accactggga ctcctacgag gccctcgccg ccgactacct ggaggcgttg
     8341 cagggcatgg ccaccctgcg cgcggccggt gccgtgggcc gcgtacggga gaagctggag
     8401 aagcggtcgg cggcgctcca ccgggcgacc gtcgccaaac tgcgggtctc gctcgccgac
     8461 accggcctca ccgacctcgc cgtgcagggc ggcaccgcgg ccgccgtcct ggtggcgtgc
     8521 tcctcggcgg ccaccggacg caccgccgcc accgggacgt acctcctgct catgctcgcc
     8581 tccgagtgct tccgccccat ccgcgacctc tcccgcgagt ggcacgcggg ctacctcggg
     8641 gtctcggccg ccgacgggat cgccgccctg cgcaccgccg accccgccgt cgcggaccgg
     8701 ggagggcgct cgcccgctgg gacaccgcgc ccccatccgc ttcgaggacg tccacttcac
     8761 ccaccccggg gcgggccgtc ccgccctcga cggcatcacc ttcaccgcac ccgccgggcg
     8821 cacgacggcg atcgtcgggc cctcgggtgc cggaaagtcc accctgctga gcctgctgct
     8881 gcgccagcgc gaccccgaca gcgggcgcgt cacgatcggc gggaccgaga ccgccgcgta
     8941 caccctcgcc tcgctgcggc gggggatcgc cgtcgtctcg caggagacgt acctcttcca
     9001 cgccacgatc gccgagaacc tgcgcgtcgc ccgccccgcc gccaccgacc aacagctgcg
     9061 cggcgccgcc cgggcggcgg gcatcgacca ggagatcacc gccttccccc aggggtacga
     9121 caccctcgtc ggcgaacgcg gcgccacgct ctccggcggc cagcgccaac gcctcgccct
     9181 cgcccgcgcc ctgctggccg acacaccggt cctgatcctg gacgaggcca ccagcgcggt
     9241 ggacgagcgc ggcgaggccc ggatcgtacg ggagttgctc gcggcgagcc ggggccggac
     9301 ctgtctcgtc gtcgcccacc gactcgacgc cgtacgccac gccgaccaca tcgtcgtcct
     9361 cgacggcggc cgggtcgagg cgtccggcga ccacagcgga ctgctggcgg acggcggcgt
     9421 gtacgcctcg ctcgtcgccg cgggccgcac cgcccaggag gaacacgccg catgaccccg
     9481 cccgacccga gcccttccgg ggcctgtacg cccgcatccg accccagccc caccggcgcc
     9541 cgtacgacct cgtccgaccg tgccgctgac cggacccgtg ccccccgcca cccccagggc
     9601 tccggcgccc tgcgctcact cctccccgtc ctcggagccc atcgcgccac cgtcctgcgt
     9661 acctgtctcg ccgccctcgt cgaccaagcg gccctcgtcg ccctggtcac cctcgccgcc
     9721 cacacggtcg gcacagccgt catcggacac cggcccccat cacccaccac cgtggccgtc
     9781 ctcatcgggc tcgtcctcct ccgggcgctc gccacctggc gggagatgga cctctcgcac
     9841 gacctcgcct accgcgtcct cgccgagctg cgcgtccggg tcttcgacgg gctcgcccgt
     9901 tccgcccccg cgcggatcgc ggggcggcgc agcggtgacc tcgcggcgac cgcgctcggc
     9961 gatgtggagg cgctggagtt cttctacgcc cacgccatcg cccaactcct cgcctccggg
    10021 ctcgtcttcg cggtggccgc caccctgctg ggcgtcctcg ggccctggct gctgctcgcc
    10081 gtcgtgcccg ccgccctgct tctgctctgg tcgcccctgc tggaggcgcg cggccgggcc
    10141 gagcgcgggg ccaggacccg ggccgcgctg gccgatctct ccgcggagag cgtggagagc
    10201 gtcgacggcc tccgggagct gctgatggcg ggcgccctgg gccgcacccg ggcccggctg
    10261 cgctccggcg gccggcggct cgcccgggcc cagcgggccg agcagtcctg ggagacgggg
    10321 gccggcgcgg tccgtgatct gctcgtcgtc gcggctgtca tcggggtggt cgccgctgcc
    10381 gcccatgcga cgggcggcgg gcgtctcgac ggggcctggg ccccggccgc catggccctg
    10441 gccctcggcg ccctggcccc ggtggccgaa tcggcggccg cactgggccg ggcgggcagc
    10501 ctgcgcgccg ccgccgcccg ggtccgggcg gccgtgcacg ccccggccgg ggcccccgcc
    10561 cccgcttccc cgcttcctgt cccgccgggt ccgctgggac tgcggctgcg cggggtccgg
    10621 ttcggctacg gctccggccc cgttctggac ggcctcgacc tcaccgtacg gccgggggag
    10681 acggtggccc tggtcggcgc ctcgggggcc gggaagacca gttgcgccca tctcctggcc
    10741 cgctactggg acccgcggga cggggcggtg gagctgctcc cggagggccg gacccacccc
    10801 gtcgacctgc gggatctcac cgaggacggc ctgcgcgccg ccgtgtgcgt ggtgggccag
    10861 gaggctccgc tcttccatgg caccctcgcc gagaacctcc gcctcggtgc tcccgacgcc
    10921 accgatcagg agctggccgc tgtcgtacgt gtctgcggcc tggcctcggt cgtcgacgcc
    10981 ctgccccagg gactggacac cccggtcggc gaacgcggcg cggccctctc cggcggtcag
    11041 cgcgcccggg tggccctggc ccgggggctc ctcggccggc cccgggtcct cgtcctcgac
    11101 gagacgacgg cccatctcga ccaccggggc gacgaggagc tggcgcgggc gctcgcggcg
    11161 gactcccggg cccgtacccg tacgaccctg atcatcgccc accggcccgc caccgtccgc
    11221 cgggccgacc gcatcgccgt cctcgacggg ggccgcatcg tcgaggaggg cacctgggac
    11281 ggactgatcc ggaccggagg cgcgctgacc cggctgttca gccgggcggg ggagaaccgg
    11341 gaggcagcgg cgacggcaga ttctgctc
//
