LOCUS       NZ_CP032543            22671 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4199700
            Orig. end                         :: 4222371
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22671
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="18"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22671
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22671
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12671](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12671
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            341..601
                     /locus_tag="D6270_RS18895"
     CDS             341..601
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511023.1"
                     /locus_tag="D6270_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3263 domain-containing protein"
                     /protein_id="WP_109164371.1"
                     /transl_table=11
                     /translation="MTASDAEPAPSPPGLSDRDRALLALERRSWAGPGAKERAIREELG
                     ISPVRYFQLLNALIEDERALREDPVTVNRLRRLRAQRRDRR"
     gene            798..1655
                     /gene="otsB"
                     /locus_tag="D6270_RS18900"
     CDS             798..1655
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958814.1"
                     /locus_tag="D6270_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trehalose-phosphatase"
                     /protein_id="WP_109164370.1"
                     /transl_table=11
                     /translation="MGSHSAQPPIPTPTTPAGREGLDAILARPERAVIALDFDGTLADI
                     VPDPERARAHPGAVEALAALAPKVASIAVITGRPADVAVRYGGFAGVPGLDHLVVLGHY
                     GAERWDAATGTVNAPAPHPGVAAARAELPGVLHEFDSWHGTWIEEKGQAVAVHTRRAED
                     PQAAFETLRGPLGELAALHGLILEPGRQVLELRPPGMDKGVALATHVAEVDAESVLYAG
                     DDLGDLAAFAAVEKLRGDGPDGIPGLLVCSGSAEVPELAERADLLVPGPAAVVDFLAAL
                     ADQL"
     gene            complement(1663..3054)
                     /locus_tag="D6270_RS18905"
     CDS             complement(1663..3054)
                     /EC_number="2.4.1.15"
                     /GO_function="GO:0003825 - alpha,alpha-trehalose-phosphate
                     synthase (UDP-forming) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101576.1"
                     /locus_tag="D6270_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_109164369.1"
                     /transl_table=11
                     /translation="MVTEHAPSSTTQVLVASNRGPITYTLGEDGTLDAKRGGGGLVSGL
                     SAVDDKLWVCAALGDGDREAVRRGVGEPGVRMLDIDAEVHADAYNGIANSVLWFVHHLL
                     YQTPVEPVFDVEFRRQWAAYETYNRAFAQALAEEAEPGASVLVQDYHLALVPGMLRELR
                     PDLRIGHFSHTPWAPVDYFRLLPDDIGEQLLRGILGADRAAFLTRRWADAFIGCCTEIL
                     GGTGRTRIGVHGLGADADFLRRRSREADVDERMEALREQVGEDRRTIVRVDRTELSKNI
                     VRGLHAYRTLLETHPEWRERVVHVAFAYPSRQDLSVYRDYTAAVQTLAAEINGAYGTES
                     WTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDHGCALVLSREAGA
                     YEELGEDAIVVNPYDVVGTAEALHEALSMSAEERTGRTKRLAEAATALPPQQWFLDQLE
                     ALRQE"
     gene            complement(3145..4095)
                     /locus_tag="D6270_RS18910"
     CDS             complement(3145..4095)
                     /EC_number="2.4.1.266"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511020.1"
                     /locus_tag="D6270_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucosyl-3-phosphoglycerate synthase"
                     /protein_id="WP_109164368.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.1e-09,
                     bitscore: 34.5, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEEVERWLTRRSWSSADRPLNRLTDARAADPHRTSVSVVLPALN
                     EEATVGAIVGTIRRELMERVRLVDELVVIDSGSTDATAAVARAAGARVVHRDAILPRIP
                     ALPGKGEVLWRSLLVTSGEIVCFVDADLRDFSADFVSGTVGPLLTDPTVQFVKAMYDRP
                     LGDSAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELG
                     LLVDALHTVGLDTLGQVDVGVRRHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPALTQ
                     FERGAEGFVPRTHAVDTEERPPMREIAEYAERWAA"
     misc_feature    4132..4152
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.36"
                     /tool="antismash"
     regulatory      4260..4387
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            4406..5701
                     /gene="thrC"
                     /locus_tag="D6270_RS18915"
     CDS             4406..5701
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056010.1"
                     /locus_tag="D6270_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="threonine synthase"
                     /protein_id="WP_109164367.1"
                     /sec_met_domain="PALP (E-value: 8.2e-61, bitscore: 204.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQTIAGNATTASVDLGPAAALSCRECGERFELGPLFACASCFG
                     PLEVAYDLPTGSAEELKKRIEAGPNNIWRYAPLLPVPADVAEKPNINPGFTKLVKADNL
                     ARELGVTGGLYVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAA
                     ARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFV
                     NVNLRPYYGEGSKTLAYEICEQLGWKLPDQIVIPIASGSQLTKIDKGFQELIKLGLVED
                     RPYKIFGAQAEGCSPVSAAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGG
                     AVEDVNDEQVVDAIKLLARTEGIFGETAGGVTLGVTKKLIEAGVIDPALTTVVLNTGDG
                     LKTLDAVSATSQATATIKPSLDAFRAAGLASA"
     misc_feature    4409..4423
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            5743..6021
                     /locus_tag="D6270_RS18920"
     CDS             5743..6021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265553.1"
                     /locus_tag="D6270_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_018511018.1"
                     /transl_table=11
                     /translation="MSVKVRIPTILRTYTGGQAEVTAEGAKLSEVIDSLEKDHPGIAAR
                     VLDDQGKLRRFVNVYVNDDDVRFEGGLDAATPDGAGISIIPAVAGGC"
     gene            6441..6647
                     /locus_tag="D6270_RS18925"
     CDS             6441..6647
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967346.1"
                     /locus_tag="D6270_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cold-shock protein"
                     /protein_id="WP_003967346.1"
                     /transl_table=11
                     /translation="MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQ
                     RVEFEISQGQKGPQADMVKLAVG"
     misc_feature    complement(6489..6502)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    6780..6795
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(6780..6798)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    6782..6796
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    complement(6783..6798)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.7"
                     /tool="antismash"
     misc_feature    complement(6817..6832)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            6950..8572
                     /gene="groL"
                     /locus_tag="D6270_RS18930"
     CDS             6950..8572
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133870.1"
                     /locus_tag="D6270_RS18930"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /product="chaperonin GroEL"
                     /protein_id="WP_093694016.1"
                     /transl_table=11
                     /translation="MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGA
                     PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR
                     NVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEA
                     MDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVN
                     SKIASVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGD
                     RRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSEQV
                     QGRVKQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR
                     NAKAAVEEGIVAGGGVALLQASAVFDKLDLTGDEATGANAVKLALEAPLKQIAVNGGLE
                     GGVVVEKVRNLPIGHGLNAASGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAV
                     IADKPEKAGAAAPGGMPGGDMDF"
     gene            8770..9297
                     /locus_tag="D6270_RS18935"
     CDS             8770..9297
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762775.1"
                     /locus_tag="D6270_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109164366.1"
                     /transl_table=11
                     /translation="MRVRAAGRAGGGRLKGGALVVGGAVLFLLGLFGVVTGTGLAGLVG
                     MRVETFGLIDCADKQVKGGTVWHCYGESEAQQRANAAERKRVADATLRVHVDGMPAPAR
                     IGRTRISFADHDGRNDPETITATQLTEGGRWFAHSSTIVGYGMVPLLLGAGTAAWGGYR
                     LREAGRRGAEGS"
     misc_feature    9379..9392
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    9548..9563
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.0"
                     /tool="antismash"
     gene            9828..9950
                     /locus_tag="D6270_RS18940"
     CDS             9828..9950
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489031.1"
                     /locus_tag="D6270_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_018511015.1"
                     /transl_table=11
                     /translation="MKQQKKAYVKPSLFKQGDFSKKTAGYFYGSYKEYWVRRII"
     CDS_motif       9828..9899
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKQQKKAYVKPSLFKQGDFSKKTA"
                     /locus_tag="D6270_RS18940_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9900..9950
                     /prepeptide="core"
                     /locus_tag="D6270_RS18940_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="0.20"
                     /molecular_weight="2082.4"
                     /monoisotopic_mass="2081.0"
                     /core_sequence="GYFYGSYKEYWVRRII"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKQQKKAYVKPSLFKQGDFSKKTA"
                     /leader_location="[9827:9899](+)"
     gene            10001..11950
                     /locus_tag="D6270_RS18945"
     CDS             10001..11950
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489032.1"
                     /locus_tag="D6270_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_109164365.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.9e-33, bitscore:
                     113.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGLLRDYFVVLPDSVAGHAVAGQLPAPDATGAARGMDGDVLTVA
                     HPSGRPWVVARPLARKVSHLRRGDDALVLIGPDRVPEAVLAGLLEGARDRTGLERRLAR
                     LPGLHHVVARLSDETWIRGTASGLRRIYHARHAEAGTLACDRPAVLARLTGAPLDDGAL
                     ALRLLDFLPHPLSRRVLWRGVHETGAGYGLALPVAAPGTAAAPGPREYRWWEPPPPELP
                     LAEGARGLGDAVAASVRAHVGGLDRISCELSGGLDSTTLTFAARATAPAELSLLTVAAR
                     DRYSEDETWARRAVEAAGTRGVGDGGHPGPATPTLAHHIIPADQAPYFYADLAATSAEL
                     NDEPLPVAPGRARAQLLLGRAHATGSRYHLTGYGGDELFLGLPHAYQDLFRGNPLTAWN
                     HLSGLRHQLGWPLLPTLKALLNRSTFPRWLAGAVTTGPQPVTRTPLLSWGVRQSLRPWF
                     TDHANALITAEFRAAAEQAEPIDPWRGRHVDIDAVRMGARHFQAMEDIGMTIGLPVAAP
                     FYDDRVLEATLAVRLEERISPWRYKPLLVEAMRGVVPDALLARTTKDHMSSDEHQGLRE
                     HAPELTDLWTGSRLAEHGLVDARHLLRLAAEPFSPVLVEHSISSTVAGETWLRTAENAW
                     KTSELTPTTTTGEA"
     aSDomain        11953..12198
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_D6270_RS18950_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.00E-27"
                     /identifier="RREFam002.1"
                     /label="D6270_RS18950"
                     /locus_tag="D6270_RS18950"
                     /protein_end="82"
                     /protein_start="0"
                     /score="87.0"
                     /tool="antismash"
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVEALAAGEA
                     PEAAVERIVAAFDVERAEAESDVAELTRQLVEAKILR"
     gene            11953..12204
                     /locus_tag="D6270_RS18950"
     CDS             11953..12204
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126488.1"
                     /locus_tag="D6270_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_109164364.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.3e-25,
                     bitscore: 87.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.4e-13, bitscore: 47.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVEALAAGEA
                     PEAAVERIVAAFDVERAEAESDVAELTRQLVEAKILRP"
     misc_feature    complement(11972..11992)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            12201..12671
                     /locus_tag="D6270_RS18955"
     CDS             12201..12671
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610348.1"
                     /locus_tag="D6270_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_109164363.1"
                     /sec_met_domain="PF13471 (E-value: 7.1e-25, bitscore: 85.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEMTMPRRGAGPGGLRLRAAIAAAFVLARFRPGRLRRVLTRCS
                     RGATPATYDETLEMYEAVTATSRRCAGRYGCLPRSVAIALACRMSGSWPDWCAGVRTAP
                     PFSPHAWVQAGGRTVGEQAESADLRPLMVVTVREGVPGERGGGDDDGGGKPA"
     gene            12745..14514
                     /locus_tag="D6270_RS18960"
     CDS             12745..14514
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489035.1"
                     /locus_tag="D6270_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_109164362.1"
                     /transl_table=11
                     /translation="MLDGSAAPPGAEAAGPAPLRLLLTRVRPHRGVLLRAGLLSLTGSA
                     AGLAMPLMAKYAVDAFAADRSPVTPLIALTALVLAGACLSAYGRYLMARTGEGVVLRAR
                     HQLVGRIMRLKVPAVDRLTPGDLQSRVTSDTTLLRTVLSSGLVESFNSVLMLLGTVAFM
                     AYMDVTLLGVTLVVIVGIGAVTALLMPRIQRAQLRAQESVGAMGAALDRVLQAFRTVKA
                     SGAEERETAAVAEAARRAHDRGVSVAKWSSVSDVTMMMSIQLAFLAVLGVGGARVASGS
                     LDISSLIAFLLYLFYLMGPIGGLVEGWTGLQSGLAAVRRIDEVESLPGEPAQEFHGLKE
                     DGGPLRVSFQDVTFGYGGERAPAHKGVTFEVPAGGMVALVGPSGAGKSTVFSLLERFYD
                     HGAGAIALNGRDIREWPLAELRASLAYVEQDAPVLAGTLRENLLFAAPDAPEARLAEAV
                     ARTRLDALVARLPDGLDTAVGHRGVTLSGGERQRIAIARALLRRPRLLLLDEVTSQLDA
                     VNEQALRDVILELAERTTVLVIAHRLSTVRHADRIVVLEEGRVRTAGTHEELIASDDLY
                     RELATTQLAAEVR"
     gene            14746..15246
                     /locus_tag="D6270_RS18965"
     CDS             14746..15246
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489040.1"
                     /locus_tag="D6270_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_109164361.1"
                     /transl_table=11
                     /translation="MTVEEFEEFYAQAVARLTGQLYVMTGDLQEAQDVVQEAFVKAWVR
                     RGRLERDGQPEAWIRTAAWRLAVSRWRFRRRSADAWGRGSGAAEHVAPPDPDHVVLVDA
                     LRELPAQQRRTLTLHYLCDLTVEQIAGETGLSASTIKTHLVRGRAALAHRLQDPHMEEA
                     PDV"
     misc_feature    complement(14761..14774)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            15963..17207
                     /locus_tag="D6270_RS18970"
     CDS             15963..17207
                     /GO_function="GO:0000009 - alpha-1,6-mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004376 - glycolipid mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967341.1"
                     /locus_tag="D6270_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mannosyltransferase family protein"
                     /protein_id="WP_204117090.1"
                     /transl_table=11
                     /translation="MSILSTGLRPTPPHPGSSEPRPQTHERRAAGAGFDRALAWLTPAD
                     RRVLRLYLLTRVSLWITAHGARWLFPRGAETRAAGPVLAPFQQWDANHYLHIARDGYFP
                     ADTGPWVEGWDNREAFFPGFPLLLRAVHTIVPNWTAAGLLISLIAGAVAVLALSRLARS
                     YVPEDADGLRTTLFFLLSPCAVFLAAGYTEALFLAFALPAWLAAQRHHWATAAALTALA
                     TTVRVSGLFLAAAVAVLFVLSARSGKGRRGAPWLALPALPPLAYSWYLHTRTGDWMAWK
                     HAQERGWYRDFHTPWEAWTNTWSAAFDGVHATGYAAMFQAELVAMVVGLALVALLVRHR
                     RLPEAVYVALSLWALGTSYWYTSIPRATLLWWPLWIGLAALSLRRPWFRTVYLSVAAPL
                     GALAALAFLTGRWAG"
     gene            <17282..>17592
                     /locus_tag="D6270_RS33225"
                     /pseudo=""
     CDS             17282..>17592
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450450.1"
                     /locus_tag="D6270_RS33225"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDLPGHGARSAQPRSLKVST"
     gene            complement(17596..18255)
                     /locus_tag="D6270_RS18980"
     CDS             complement(17596..18255)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511003.1"
                     /locus_tag="D6270_RS18980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_109164359.1"
                     /transl_table=11
                     /translation="MPAQPSHNPPHTGPDTLRADARENRDRILRAAREAYALHGIDVPI
                     SAIARRAGVGVATLYRRFPTRTSLITEAFAEQLAECAGVLDDALEDPDPWRAFCSVFTE
                     VSAMQAADRGFTHAFLARFPDEPSYAGERDRAEEGLALLVRRAKEAGALRPDFDVSDVV
                     LALLANSGVVNGAQAKSAEASRRLVGYLLESFRARPDIEQLPPPARLELDRLGGAR"
     gene            18356..19321
                     /locus_tag="D6270_RS18985"
     CDS             18356..19321
                     /NRPS_PKS="Domain: PKS_ER (28-318). E-value: 6e-33. Score:
                     106.2. Matches aSDomain:
                     nrpspksdomains_D6270_RS18985_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047546.1"
                     /locus_tag="D6270_RS18985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_109164358.1"
                     /sec_met_domain="ADH_N (E-value: 4.6e-08, bitscore: 31.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 6.1e-14, bitscore:
                     50.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDMRAALYDSYGPPEVLYEGRVPVPVRKPGEVLVRVHATSVNGG
                     ELHGRAGKVRLVTGRRFPQRTGIDFAGEVAEVDASVTGLREGDRVWGILPRGRNGFGSA
                     AEYVSVRPRRIAYAPENVTLTEAVSLSAGGTTSLTALRDKARLRAGERLLVRGASGGVG
                     SVAVQLGKALGAHVTGLAGAGNLDFVRELGADEAIDRRATALSELGPYDVIMDTVGTEH
                     RSLQGLLAPRGRLVSIAFDIDHPAKGIGYILASAVHGGRRVRFFSGNPKHDLFAELAAY
                     VERGDLRPVVDTVHPLSGIAAAHRALEAGGVRGKHVIRVV"
     aSDomain        18440..19309
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS18985_PKS_ER.1"
                     /evalue="6.00E-33"
                     /label="D6270_RS18985_PKS_ER.1"
                     /locus_tag="D6270_RS18985"
                     /protein_end="318"
                     /protein_start="28"
                     /score="106.2"
                     /tool="antismash"
                     /translation="KPGEVLVRVHATSVNGGELHGRAGKVRLVTGRRFPQRTGIDFAGE
                     VAEVDASVTGLREGDRVWGILPRGRNGFGSAAEYVSVRPRRIAYAPENVTLTEAVSLSA
                     GGTTSLTALRDKARLRAGERLLVRGASGGVGSVAVQLGKALGAHVTGLAGAGNLDFVRE
                     LGADEAIDRRATALSELGPYDVIMDTVGTEHRSLQGLLAPRGRLVSIAFDIDHPAKGIG
                     YILASAVHGGRRVRFFSGNPKHDLFAELAAYVERGDLRPVVDTVHPLSGIAAAHRALEA
                     GGVRGKHVI"
     CDS_motif       18803..18862
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS18985_0001"
                     /evalue="4.00E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="D6270_RS18985"
                     /protein_end="169"
                     /protein_start="149"
                     /score="16.2"
                     /tool="antismash"
                     /translation="GERLLVRGASGGVGSVAVQL"
     gene            complement(19525..20952)
                     /locus_tag="D6270_RS18990"
     CDS             complement(19525..20952)
                     /EC_number="3.2.1.21"
                     /GO_function="GO:0008422 - beta-glucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848366.1"
                     /locus_tag="D6270_RS18990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH1 family beta-glucosidase"
                     /protein_id="WP_109164357.1"
                     /transl_table=11
                     /translation="MTAVDARPATSTGARPETGKVLRFPAGFRWGTATAAYQIEGGATE
                     DGRTPSIWDTFSRTPGKVRNGDTGDIAADHLHRMPEDVKLMRELGVTDYRFSVSWPRVQ
                     PTGRGPAVERGLDFYRRLVDELLGAGIRPVATLYHWDLPQELEDAGGWPERDTAHRFAE
                     YAGLVAGALGDRVSTWTTLNEPWCGAFLGYGNGVHAPGRTSDLAALRAAHHFNLAHGGA
                     TRVLRDRLPSTAEVSLTLNLHALRPLSDTDADRDAVRRIDAVANRIFLDPVFHGRLPQD
                     LVADTAAVTDWSFVKDGDLEVTSTPIDSLGINYYSPSVVSAGSSDSPSPWAGAEQHVAF
                     TPAEGPRTAMDWPVDADGLYELLTRLRDELPDLPLLVTENGAAYDDYADPEGQVHDPER
                     VAYLDAHLSAVHRAIEDGVDVRGYFLWSLLDNFEWAYGYSKRFGIVHVDFASQRRTVKD
                     SARWYAGVVARGGLERG"
     misc_feature    complement(20938..20952)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(21019..21930)
                     /locus_tag="D6270_RS18995"
     CDS             complement(21019..21930)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452097.1"
                     /locus_tag="D6270_RS18995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_109164356.1"
                     /transl_table=11
                     /translation="MTALVAPPTAPETGRPPQDPPGKRVRKGGAGRTMKGGWLSYLILG
                     FALLISAFPFYWTIVAASRSNADMAQVPPSLLPGSNLIKNFDAVLEEADIGKALLNSLI
                     VSSSITLGTVLCCTLAGFAFAKLKFRGRGALLTLTIGTMMIPPQLGVIPLFMLIAELQW
                     VNQLQAVILPGLVSAFGVFFMRQYLVQSLPDELIEAARVDGASTARIFWSIVIPIARPG
                     MAVLGMLTFMTAWNDFFWPIIALSSQEPTVQVALRQLGGGYVNDQSVIMAGTLLGTLPV
                     LLVFGLLGRQIVGGIMQGAVKG"
     misc_feature    22333..22347
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 gccaggcgat cggcaagttc ttcgactacg cctactccga cgagaacgtg ctcgccttcg
       61 ccgacgagta cgacctgctg ccggtgaccg gcagcgcgtc cgccgagatg gagaccgacg
      121 ccaagcacgc gaagctgcgc gagttcctgg cggcgctgcc caactcccag ctgcctccct
      181 tcggcaagac gtcctgggcg acggtgagcg aggcgatcaa gacgaacatc ggcgaggcgg
      241 tcgcgcccgg cgggagcccg gagcgggtgc tcggggcgat agcggccgag gcgacgaagg
      301 cggagagcgc ggagtaggcg ggcgcggtta ggttggttgt atgaccgctt ccgacgccga
      361 gcccgcgcct tcccctccgg ggctgtccga ccgtgaccgt gcgctgctcg cgctggagcg
      421 gaggtcatgg gcggggccgg gggcgaagga gcgggcgatc cgggaggagc tgggcatctc
      481 tccggtccgc tacttccagc ttctcaacgc gctgatcgag gatgagcggg cgctgcggga
      541 ggatccggtg acggtgaacc gcttgcgccg gctgcgggct cagcggcggg accgccgctg
      601 agccttcccg ggggcgccgc gcccggaccc ccgctcctcc atcgccggag gggctgagac
      661 cgggtgccct ctgcggccgt gcgtgaccgg ccgaggcccg cagttccagc ccctccggcg
      721 cttgaggagc ggggtgcggg gcggagcccc gggtgggcca ggtcccgtgc tcggccgcac
      781 ccggctacgc tcgacccatg ggcagccact ccgcacagcc gccgatcccg accccgacca
      841 ccccggccgg ccgcgagggc ctggacgcca tcctcgcccg gcccgagcgc gcggtcatcg
      901 ccctcgactt cgacggcacg ctcgccgaca tcgtcccgga ccccgagcgc gcccgcgccc
      961 accccggcgc cgtcgaggcg ctcgccgcac tcgcgccgaa ggtcgcctcc atcgccgtga
     1021 tcaccggccg ccccgcagac gtcgccgtcc ggtacggcgg cttcgcgggc gtccccggcc
     1081 tcgaccacct cgtggtcctc ggccactacg gcgcggagcg ctgggacgct gccaccggca
     1141 ccgtgaacgc ccccgccccg caccccggcg tcgccgccgc gcgggccgaa ctccccggcg
     1201 tactgcacga gttcgactcc tggcacggca cctggatcga ggagaagggg caggccgtcg
     1261 ccgttcacac ccgccgcgcc gaggacccgc aggcggcctt cgagaccctg cgcggccccc
     1321 tcggcgaact ggccgcgctc cacgggctga tcctggaacc gggccgccag gtcctggagt
     1381 tgcgcccgcc gggcatggac aagggcgtcg ccctggccac ccacgtcgcc gaggtcgacg
     1441 ccgagtccgt cctgtacgcg ggcgacgacc tcggggacct cgccgccttc gccgcggtgg
     1501 agaagctgcg cggcgacggc ccggacggca tccccggcct gctggtgtgc agcggcagcg
     1561 ccgaggtgcc cgaactggcc gaacgagccg atctgctggt gcccggcccg gccgccgtgg
     1621 tggacttcct cgcggccctg gccgatcagc tgtaggcgct cctcactcct gccgcagcgc
     1681 ctccagctgg tccaggaacc actgctgcgg cgggagcgca gtcgccgcct ccgccagccg
     1741 cttcgtgcgc ccggtccgct cctcggcgct catcgacagg gcctcgtgca gcgcctccgc
     1801 cgtgcccacc acgtcgtacg ggttcaccac gatcgcgtcc tcgcccagct cctcgtacgc
     1861 cccggcctcc cgtgacagca ccagcgcgca gccgtggtcg gagacgacgg ggacctcctt
     1921 ggcgaccagg ttcataccgt cccggatcgg gttgaccagg gccacatccg ccagccggta
     1981 cgcggcgagc gagcgggcga agtcgtcctt cacgtggagg acgacgggcg tccaactctc
     2041 cgtgccgtag gccccgttga tctccgcggc cagggtctgc accgccgccg tgtagtcccg
     2101 gtagaccgag aggtcctggc gggaggggta ggcgaaggcg acgtggacca cgcgctcgcg
     2161 ccactcgggg tgggtctcca gcagggtccg gtaggcgtgc aggccgcgca cgatgttctt
     2221 ggacagttcc gtacggtcca cccgcacgat ggtcctccgg tcctcgccca cctgctcccg
     2281 cagcgcctcc atgcgctcgt cgacgtccgc ctcccgcgac cgccgccgca ggaagtccgc
     2341 gtccgccccc agcccgtgca ccccgatcct ggtccggccc gtcccgccga ggatctccgt
     2401 acagcagccg atgaacgcgt ccgcccaccg ccgggtcagg aacgcggccc ggtccgcgcc
     2461 caggatgccg cgcagcagct gctcaccgat gtcgtcgggc agcagccgga agtagtccac
     2521 cggcgcccac ggggtgtgcg agaagtggcc gatcctcagg tccgggcgca gctcgcggag
     2581 catcccgggg accagggcca ggtggtagtc ctgcaccagg accgaggccc ccggctccgc
     2641 ctcctcggcc agcgcctggg cgaaggcccg gttgtacgtc tcgtacgcgg cccactgacg
     2701 ccggaactcc acgtcgaaga ccggctccac gggcgtctgg tacagcaggt ggtggacgaa
     2761 ccacagcacc gagttggcga tgccgttgta cgcgtcggcg tggacctcgg cgtcgatgtc
     2821 gagcatccgt acgcccggct caccgactcc gcgccgtacc gcctcgcggt cgccgtcgcc
     2881 gagggccgcg cagacccaga gcttgtcgtc gacggcgctc agcccggaga cgagcccgcc
     2941 gccgccgcgc ttggcgtcga gagtcccgtc ctcgccgagc gtgtacgtga tcgggccgcg
     3001 gttggacgcg acgaggacct gggtggtgga ggagggtgcg tgctcggtga ccatgtagcg
     3061 gaacctagcc cgtaagggaa gccgccaaac gcctcagagc ctcacgcccg cgcgcacctc
     3121 agggccgccg gcgccccgca cgcctcacgc cgcccaccgc tccgcgtact ccgcgatctc
     3181 ccgcatcggc ggccgctcct ccgtgtccac cgcatgcgtg cgcggcacga acccctccgc
     3241 gccccgctcg aactgcgtca gcgccgggcg caccagatgc ccccgggaga gccgcagctg
     3301 cgccgtgcgg tagatcgccg ccgccatccg gcccagcgcc tgcccgtcct ggtggcggtg
     3361 gcgccgcacc ccgacatcca cctggcccag cgtgtccagc cccacggtgt gcagcgcgtc
     3421 cacgagcagc cccagctcca ctccgtaacc gaccgggaac ggcagccgct ccagcagcga
     3481 gcgccgcacc gcgtactccc cgcccagcgg ctgcacgaaa cccgccagct gcggccagtg
     3541 cagattgagc aggggacgtg ccaccagttc ggtgacgcgg cctccctgac ctgcgctgtc
     3601 gccgagagga cggtcgtaca tcgccttgac gaactgcacg gtgggatcgg tgagcagcgg
     3661 cccgaccgtc cccgagacga agtccgccga gaagtccctc aggtccgcgt cgacgaagca
     3721 gacgatctca ccgctggtca ccaggagcga ccgccagagc acctcgccct tgccgggcag
     3781 cgccgggatc cggggcagga tcgcgtcccg gtgcaccacc cgggcgcccg ccgcccgcgc
     3841 gacggccgcg gtggcgtcgg tggaaccgga gtcgatcacc accagctcgt cgaccagccg
     3901 gaccctctcc atcagctccc gccggatggt ccccacgatc gcgccgaccg tggcctcctc
     3961 gttcagcgcg ggcagcacca cgctcaccga cgtacggtgc gggtcggcgg cccgggcgtc
     4021 ggtgagccgg ttcagcgggc ggtcggcgga cgaccaggaa cgcctggtca gccagcgttc
     4081 cacctcttcg agcacggtcg gcactccttg cgtgtgagcg gtatgtgatc catctcgccg
     4141 ttcggacgac tatctcaaca gtccggtcct tcggttacag tcttgaacaa cgcggatgac
     4201 cgtcgcatgt cggggtccgt ccgcacacaa acgcctggat cgaagatcca gtgccacaga
     4261 gctcatccag agggactgag ggaacggccc gttgaagtcc cggcaaccct cctaccgacc
     4321 gcgaggtcac ggtggggaag gtgccaattc cgtcttgtgg cgaaatgcgc cgcgaggaag
     4381 atgaggagaa agggcctccg ccatcatggc tgttcagacc attgcaggta atgccaccac
     4441 cgcttccgtg gacctcggtc ccgccgcggc gctttcctgc cgcgagtgcg gcgagcgttt
     4501 cgagctcggc ccccttttcg cctgtgcgtc ctgtttcggg ccactggaag tggcgtacga
     4561 cctgccgacc ggttccgccg aggagctgaa gaagcgcatc gaggccggcc cgaacaacat
     4621 ctggcgctac gccccgctgc tgccggtccc cgccgatgtc gcggagaagc ccaatatcaa
     4681 ccccggtttc accaagctgg tcaaggccga caacctcgcc cgtgagctgg gcgtcaccgg
     4741 cgggctgtac gtcaaggacg actccggcaa cccgacgcac tccttcaagg accgcgtcgt
     4801 cgcgatcgcc gtcgaggccg cccgcgcctt cggcttcacc accctctcct gctcctccac
     4861 gggcaacctg gccggtgccg tcggcgccgc cgccgcccgc gccggactgc gctcgtgcgt
     4921 cttcatcccg cacgacctgg agcagggcaa ggtcgtcatg gccgcggtgt acggcggtga
     4981 gctggtcggc atcgagggca actacgacga cgtcaaccgc ttctgctccg agctcatcgg
     5041 cgacccgctc ggcgagggct ggggcttcgt caacgtcaac ctgcgcccgt actacggcga
     5101 gggctccaag accctggcgt acgagatctg cgagcagctc ggctggaagc tgccggacca
     5161 gatcgtcatc ccgatcgcgt ccggctccca gctgacgaag atcgacaagg ggttccagga
     5221 gctgatcaag ctcggcctgg tcgaggacag gccgtacaag atcttcggtg cccaggccga
     5281 gggctgctcc ccggtctccg ccgccttcaa ggccgggcac gacgtcgtac ggccccagaa
     5341 gccgaacacc atcgccaagt ccctggccat cggcaacccg gcggacggcc cgtacgtcct
     5401 cgacatcgcc cgtcgtacag gcggcgcggt ggaggacgtg aacgacgagc aggtcgtcga
     5461 cgcgatcaag ctgctggcgc gcaccgaggg catcttcggc gagacggcgg gcggtgtgac
     5521 gctcggcgtg accaagaagc tgatcgaggc cggtgtgatc gacccggcgc tcaccaccgt
     5581 cgtcctgaac accggtgacg ggctcaagac cctcgacgcg gtctccgcga cctcgcaggc
     5641 cacggccacc atcaagccga gcctggacgc gttccgcgcc gcgggcctcg cctccgcctg
     5701 acgacccacc gcaccgagac cgaagcaaga agggcaccca ccatgagcgt caaggtccgc
     5761 atccccacca tcctccgcac gtacacgggc ggccaggccg aggtcacggc ggagggcgcg
     5821 aagctctccg aggtcatcga ctccctggag aaggaccacc cgggcatcgc cgcccgcgtc
     5881 ctggacgacc agggcaagct gcgccgcttc gtgaacgtgt acgtcaacga cgacgacgtg
     5941 cgcttcgagg gcggcctcga cgccgccacg cccgacggcg ccggcatctc gatcatcccg
     6001 gccgtggccg gcggctgctg atccgacgac tctcagctga acagcagttg ccccctccgc
     6061 gacacagagc ggagggggca attctgcatg gttgagcgcg gtagagttgg ggaaggcccc
     6121 ctcgccgcgt gtgccgcccg catatgagaa tgcgcccggc cccgataaga agcagccaaa
     6181 gtacgtgaac cccttgaggc ataagtggcc tttgcctggc ccgacttgcc cgtaaatctc
     6241 agcaatcccg catattcggg cgttcgcccg tgcccagaat tctcgtccga ttgacctgtt
     6301 gcagagggca gttgggcgga tacattcggc cgcggtcgac gcgctgcggc gccgcgcacc
     6361 ctctcctgtc ggagggtgag ttccgacccg gggccgcgaa gtgcggtccc gtgcaagggc
     6421 cagttatagg ggagttaggc atggctcagg gcaccgtcaa gtggttcaac gcggagaagg
     6481 ggtacggctt catcgcggtc gacggtggtg cggatgtttt cgtccactac agcgcgatcc
     6541 agatggacgg gtaccgcacc ctcgaagagg gtcagcgagt tgaattcgag atctcgcagg
     6601 gccagaaggg gccccaggcc gacatggtca agctcgctgt cggctgagtc cggcgcggcc
     6661 gtccggcacc actactcacg cacgtagggc ccgaccccgg atcaggggat cgggccctac
     6721 gcgcgtgccg ggaccggatg gcgggccctg gcctgaggcg cttgcactct cgggggtcga
     6781 gtgctaatca ttggcattag cactctccag gtgagagtga cagaaacttg gaccgggccg
     6841 gtgaggcccg caggcgcggt ggggcaagga accaccacgc acgcaggccg tccgtcgcgg
     6901 gcgcctctcg gtccggagaa tccacccctg tccgggagga ccacttcaca tggccaagat
     6961 catcgcgttc gacgaggagg cacggcgcgg tctcgagcgc gggatgaacc agctcgccga
     7021 cgccgtcaag gtcaccctcg gccccaaggg ccgtaacgtc gtcctcgaga agaagtgggg
     7081 cgcgcccacg atcaccaacg atggtgtttc catcgccaag gagatcgagc tcgaggaccc
     7141 gtacgagaag atcggtgcgg agctggtcaa ggaggtcgcc aagaagacgg acgacgtcgc
     7201 cggcgacggt acgaccaccg ccaccgttct cgcccaggct ctcgtccgcg agggtctgcg
     7261 caacgtcgcc gcaggcgcca acccgatggc cctcaagcgg ggcatcgaga aggccgtcga
     7321 ggccgtctcc gccgctctgc tggagcaggc caaggacgtg gagaccaagg agcagatcgc
     7381 ttcgaccgcc tccatctccg ccgccgacac cgagatcggt gccaagatcg ccgaggcgat
     7441 ggacaaggtc ggcaaggaag gcgtcatcac cgtcgaggag tcccagacct tcggtctgga
     7501 gcttgagctc accgagggta tgcgcttcga caagggctac atctcggcct acttcgcgac
     7561 cgacatggag cgtatggagg cgtccctcga cgacccgtac atcctgatcg tcaactcgaa
     7621 gatcgccagc gtcaaggacc tgatcccgct gctggagaag gtcatgcagt cgggcaagcc
     7681 gctgctgatc atcgccgagg acgtcgaggg cgaggcgctc tccaccctgg tcgtcaacaa
     7741 gatcaagggc acgttcaagt ccgtcgccgt caaggccccg ggcttcggcg accgccgcaa
     7801 ggccatgctc gcggacatcg ccatcctcac cggtggcacc gtgatctccg aggaggtcgg
     7861 tctcaagctg gagaacgccg gcctggacct gctcggccgt gcccgcaagg tcgtcatcac
     7921 caaggacgag accacgatcg tcgacggtgc cggtgacagc gagcaggtgc agggtcgcgt
     7981 caagcagatc cgcgccgaga tcgagaactc cgactcggac tacgaccgcg agaagctcca
     8041 ggagcgcctc gcgaagctgg ccggcggcgt ggccgtcatc aaggccggcg ccgccaccga
     8101 ggtggagctc aaggagcgca agcaccgcat cgaggacgcg gtgcgcaacg ccaaggccgc
     8161 cgtcgaggag ggcatcgtcg ccggtggtgg cgtggctctg ctccaggcct cggccgtctt
     8221 cgacaagctg gacctcacgg gtgacgaggc gaccggcgcc aacgccgtga agctcgcgct
     8281 ggaggccccg ctcaagcaga tcgccgtcaa cggtggtctc gagggtggcg tcgtcgtcga
     8341 gaaggtccgc aacctgccga tcggtcacgg cctcaacgcc gcgtccggcg agtacgtgga
     8401 catgatcgcc gagggcatca tcgacccggc gaaggtcacg cgctccgctc tgcagaacgc
     8461 cgcctccatc gccgcgctct tcctcaccac cgaggccgtc atcgccgaca agcccgagaa
     8521 ggccggcgcg gccgctccgg gtggcatgcc gggcggtgac atggacttct gatcgggtcc
     8581 ccacgaccgg tcgaagctcc acgcacgtcc cacaggggcg gtacctcctt cacggggggt
     8641 gccgcccctg tggcgtgtcc gggttccttg ggacactgcg gggacgggac gccgcgttcg
     8701 gatgcgggtc ccgcggatgc gggacgcggc acatggatgc gggtcccgcg gatacggggg
     8761 cggaacggta tgcgtgtgcg tgctgcgggg agagcgggtg gagggcggct caaggggggc
     8821 gcgctcgtcg tgggcggggc ggtgctgttc ctgctgggac tgttcggcgt ggtgaccggc
     8881 accggcctcg ccgggctcgt cgggatgcgg gtggagacct tcggcctgat cgactgcgcc
     8941 gacaagcagg tcaagggggg aaccgtctgg cactgctacg gcgagagcga ggcccagcag
     9001 cgcgccaacg cggccgagcg caaacgggtc gccgatgcga ccctgcgcgt ccatgtggac
     9061 gggatgcccg ccccggcgcg gatcgggcgc acccggatca gcttcgcgga ccacgacggc
     9121 cggaacgacc ccgagacgat caccgcgacc caactgaccg agggcgggcg gtggttcgcc
     9181 cactcgtcga cgatcgtcgg ctacgggatg gtcccgctgc tgctgggcgc ggggacggcg
     9241 gcctggggcg gttaccggct gcgcgaagcg gggcgacggg gcgcggaggg gtcctgaagg
     9301 acgcccagaa cctctgacgg agccgaacga gcggtcgggc atggccgaat ggctacttgc
     9361 aggcccccgt gccgtacgac aacacacgtt cggtcggttt cggtggtgtc ggtggcgcgc
     9421 cggtctccgg tggggtaaag cggctgcggg cgccaccggg tgcgcggcgc cggtggttcc
     9481 tccgctccgc cgtggacggc ccgatctccc agcagctcac cgccagggcg gacgcctccg
     9541 tgcagaaatt ggtccagtcc acttgcccgc gccggccctc cggtgtgcga ctgcacatgc
     9601 cgaccggtcg gtgcccggcg gcgcggccgg tgccaccgcc tcccaccccc gccgctcgcg
     9661 ctatccggcc aacttcgcgt agtgagtcgg aatcacgcgt accggtcggg cagcgggaca
     9721 tgatggccct ggtgttcacc tggtgaacac cagtcgcatg aataactcca gttacgcgtt
     9781 tgccatatgg gcataacggt cgtcaaccgc acagagagga aggtgtcatg aagcagcaga
     9841 agaaggccta cgtgaagccg tcgctgttca agcagggcga cttctcgaag aagaccgccg
     9901 gttacttcta cggctcgtac aaggagtact gggtccggcg catcatctga accgccgacc
     9961 ggttccctct gcacggtgtg agaacttccg aaaggtgaag atgcccggcc tgctgcgtga
    10021 ctacttcgtc gtcctgccgg acagcgtggc gggccacgcg gtggccgggc agcttcccgc
    10081 accggacgcg accggggcgg cccgagggat ggacggcgac gtcctgaccg tcgcccaccc
    10141 ctcgggccgc ccctgggtcg tcgcccgccc cctggcccgc aaggtcagcc acctccgccg
    10201 gggcgacgac gccctcgtgc ttatcggccc ggaccgcgtc cccgaggccg tgctcgccgg
    10261 cctcctggag ggcgcccgcg accggaccgg cctggagcgc cgactcgccc ggctccccgg
    10321 cctgcaccat gtggtcgccc ggctctccga cgagacctgg atccgcggta cggcctccgg
    10381 gctgcgccgg atctaccacg cccggcacgc cgaggccggg accctcgcct gcgaccgccc
    10441 ggccgtcctc gcccgcctga ccggcgcgcc cctggacgac ggcgcactcg ccctccgcct
    10501 gctggacttc ttgccgcacc ccctgagccg gcgcgtgctg tggcggggtg tgcacgagac
    10561 cggggccggg tacggactgg ccctgcccgt cgcagcaccg ggcacggcag ccgcccccgg
    10621 ccctcgcgag taccgctggt gggagccccc gccgccggaa ctccccctgg cggaaggggc
    10681 ccgagggctc ggggacgccg tcgccgcctc cgtacgggcc catgtcggcg gcctggaccg
    10741 gatcagctgc gagctctccg gcggcctgga ctcgacgacc ctcaccttcg ccgcccgcgc
    10801 gaccgccccg gcggagctgt ccctcctgac cgtggcggcc cgggaccgct acagcgagga
    10861 cgagacctgg gcacggaggg cggtggaggc ggccggaacg cggggcgtgg gggacggtgg
    10921 acacccgggc ccagccaccc ccaccctggc ccaccacatc atccccgccg accaggcccc
    10981 gtacttctac gccgacctgg ccgccacctc cgccgagctc aacgacgaac cgctcccggt
    11041 ggcccccggc cgggcccgcg cgcaactgct cctcggccgc gcccacgcca ccggctcccg
    11101 ctaccacctc accggctacg gcggcgacga actcttcctc ggcctgcccc acgcctacca
    11161 ggacctcttc cgcggcaacc ccctcaccgc ctggaaccac ctcagcggcc tgcgccacca
    11221 gctcggctgg cccctcctcc ccaccctgaa ggccctgctg aaccgctcca cgttcccccg
    11281 ctggctcgcg ggcgcggtca ccaccggacc gcagccggtc acccggaccc cgctgctctc
    11341 ctggggcgta cggcagtccc tgcgcccgtg gttcacggac cacgcgaacg ccctgatcac
    11401 cgcggagttc cgggcggccg ccgagcaggc cgagccgatc gacccgtggc gggggcggca
    11461 tgtggacatc gacgcggtac ggatgggggc gcggcacttc caggcgatgg aggacatcgg
    11521 catgacgatc gggctgccgg tcgccgcgcc cttctacgac gaccgggtcc tggaagcgac
    11581 cctcgccgta cgcctggagg agcggatcag cccctggcgc tacaagcccc tgctggtcga
    11641 ggcgatgcgc ggggtggtgc cggatgcgct gctggcccgt acgacgaagg accacatgtc
    11701 ctccgacgaa caccagggcc tgcgcgaaca cgctccggaa ctgaccgact tgtggaccgg
    11761 ctcccgcctc gccgaacacg gcctggtgga cgcccgccac ctcctccgac tggcggccga
    11821 acccttctca cccgtcctgg tggagcactc catcagctcc acggtggccg gtgagacctg
    11881 gctccgcacg gccgaaaacg cctggaaaac atccgagttg acccccacga ccacgaccgg
    11941 tgaggcatga ctgtgaagct cagaaaaggc atagccgtca cgacgacgga gtacggcggc
    12001 gtcctgctgg acgagaagag cggcagctac tggcagttga acgacaccag cgtgatcgtg
    12061 gtcgaggccc tggcggccgg ggaggcccct gaagcggccg tcgaacgcat cgtcgccgcg
    12121 ttcgacgtgg agcgcgccga ggcggagtcg gatgtggccg agctgacccg ccagctcgtc
    12181 gaagcgaaga tcctgcgccc atgaccaccg agatgacgat gccccgccgg ggcgcgggcc
    12241 cgggcggtct gcggctgcgc gccgcgatcg ccgccgcgtt cgtgctggcc cgcttcaggc
    12301 cgggccgcct gcgccgggta ctgacccggt gcagcagggg agcgaccccg gcgacgtacg
    12361 acgagacgct ggagatgtac gaggcggtca ccgccaccag ccgccgctgc gcgggccgtt
    12421 acggctgtct gccccgctcg gtggccatcg cgctggcgtg ccggatgtcg gggagctggc
    12481 cggactggtg cgcgggggtc cggacggcac cgccgttctc gccgcatgct tgggttcagg
    12541 cggggggacg tacggtcggc gagcaggcgg agtcggccga tctgcgtcct ttgatggtgg
    12601 tgacggtacg cgagggggtt ccgggtgagc gcggtggcgg ggacgacgac gggggcggaa
    12661 agcctgcctg aggggcctga ggggcctgag gggcctcatg cgcctcatgg acctggggag
    12721 gccggtacgc ctgacggacc cggggtgctt gacgggagcg cggcgccccc cggcgcggag
    12781 gcggccggcc ccgcccccct ccgcctcctc ctcacccggg tccgccccca ccgcggcgta
    12841 cttctccggg cgggcctgct ctcgctcacc ggctcggcgg ccgggctggc gatgccgttg
    12901 atggcgaagt acgcggtcga cgcgttcgcc gccgaccgct cgccggtgac cccgctcatc
    12961 gcgctcaccg cactggtcct cgcgggcgcc tgcctctccg cgtacgggcg ttacctcatg
    13021 gcccgtacgg gagagggcgt cgttctccgc gcccgccacc aactggtggg caggatcatg
    13081 cggttgaagg tcccggcggt ggaccgcctc acccccgggg acctccagtc ccgcgtcacc
    13141 agcgacacca ccctcctccg aacagtcctc tccagcggcc tggtcgagtc gttcaacagc
    13201 gtgctgatgc tgctggggac ggtcgcgttc atggcgtaca tggacgtcac actgctgggc
    13261 gtgacgctgg tggtgatcgt cgggatcgga gccgtgaccg ctctgctcat gccgcgcatt
    13321 cagcgcgcgc agctccgggc acaggagtcg gtcggggcga tgggcgcggc gctggaccgg
    13381 gtcctccagg cgttccgtac ggtcaaggcg agcggagccg aggagcgcga gacggcggcc
    13441 gtggcggagg cggcgcggcg cgcgcacgac cggggcgtgt cggtggcgaa gtggtcgtcg
    13501 gtctccgacg tcacgatgat gatgtcgatc caactggcct tcctggccgt gctgggagta
    13561 ggcggagcga gggtggcgtc gggctccctc gacatctcgt cactgatcgc gttcctgctc
    13621 tacctcttct acctgatggg cccgatcggc ggcctggtcg agggctggac gggcctgcag
    13681 agcggcctcg cggccgtgcg gaggatcgac gaggtggagt cgctgccggg cgaaccggcg
    13741 caggaattcc acggattgaa ggaggacggc ggccccctgc gggtctcctt ccaggacgtg
    13801 accttcgggt acgggggcga gcgcgccccc gcccacaagg gcgtcacgtt cgaggtcccg
    13861 gcgggcggga tggtggcgct ggtgggcccg tcgggggcgg gcaagtcgac ggtgttcagc
    13921 ctgctggagc ggttctacga ccacggtgcg ggagccatcg cgctgaacgg ccgggacatc
    13981 agggagtggc cactggcgga gctgcgggcc tcgctcgcgt acgtggaaca ggacgccccg
    14041 gtcctggccg ggacgctgag ggagaacctg ctcttcgcgg ccccggacgc gccggaggcc
    14101 cggctggcgg aggcggtggc ccggacccgc ctggacgcgt tggtcgcccg gctgcccgat
    14161 ggcctggaca cggcggtcgg ccaccggggc gtcaccctct ccggcggcga acgccagcgc
    14221 atcgccatcg cccgcgccct gctgcgccgc ccccggctgc tgttgctgga cgaggtgacc
    14281 tcgcaactgg acgcggtgaa cgagcaggca ctgcgcgatg tgatcctgga actggccgag
    14341 cgcaccacgg tgttggtcat cgcgcaccgc ctctccacgg tccgccacgc cgaccgcatc
    14401 gtggtcctgg aggagggccg cgtccgcacg gcgggcacgc acgaggagct gatcgcgtcg
    14461 gacgacctct accgcgaact ggcgacgaca cagctggcgg cggaggtgcg gtgagggggc
    14521 agccggtgcg gtcggccctt cccggcagac atcatcggta ggccctcaga ggcgggtggg
    14581 ggagggctga gcgccggggg tgcgggctgc cgcggacccg ggctgacgcg tccccgacct
    14641 tccgggttcc gtgacgacga tcactccgaa ggctcgccgg ggctgtagac cggatgccct
    14701 gcggcaggcg tatacccggt gaagcgaaag atccgggagc gacttttgac cgtcgaggag
    14761 ttcgaagagt tctacgccca ggcggtcgcg cgtctcacag gccagctgta cgtgatgacg
    14821 ggggacctcc aggaggcgca ggacgtcgtg caggaggcct tcgtcaaggc gtgggtccgg
    14881 cgcggccggc tggagcgtga cgggcagccc gaggcgtgga tccgtacggc cgcgtggcgt
    14941 ctggcggtga gccggtggcg gttccggcgg cgttcggcgg acgcgtgggg ccgggggagc
    15001 ggtgcggcgg agcacgtggc gccgccggac ccggaccacg tggtgctggt cgacgcgctc
    15061 cgggagctgc ccgcacagca gcggcggacc ctgaccctgc actacctgtg cgacctcacg
    15121 gtggagcaga tcgccgggga gaccgggctt tccgccagca cgatcaagac gcatctggtt
    15181 cgcggacggg cggcgctcgc ccaccgtctg caggaccccc acatggagga ggctcctgat
    15241 gtctgaacca cgggacccct gggggccgga gcgatcgcag gggcgccggg gctcctcggg
    15301 tccacaggat ccgctgcgtt ccctgttccg gcaggccggg gacttcggcc agagccgctc
    15361 tgtggcggac ccggcggccg gtatcaccga acgcggcatg cgggcccagc ggcgccggat
    15421 ggccgcggtc gcggtcgggg tgtgcctggt catcgggggc atcggtgcgg cggcgatcgg
    15481 cctgctcccg accaccccga cgccggcccc tccggcgacg agcccgtcgc cgagctaccc
    15541 gtccccggct ccgccaccgc cggtcgggac ccctacggag ccgccgacgc ccagtaacac
    15601 ggtgccgggt tcggcgacga ggtcgtcccc tccgggggca tgccgacggc ggaggggtcg
    15661 tcgcctccat cggcatcgag atcgacatcg acgacggggg cgacgtcggc gccgtaacgg
    15721 tcaacgctgt agcggctagc ggctagcggc tagcggctag cggctagcgg ctgacggctg
    15781 acggctgacg gccggacgtc tgatggctga cggctgaccc gacggcccat ggctcacggc
    15841 gagcctgcgg ctgcccccgc tcccgaccgg ctcgccctcc tcctccgctc tcctccctcc
    15901 ccgtgccccg gcggctccac cgggcgatcc ggcacgcctc gacgtgcccg aaaggtgcct
    15961 gagtgtccat attgtccacc gggttgcggc ccaccccgcc ccaccccgga agctccgagc
    16021 cccggccgca gacgcacgag cgccgggcag ccggggcagg gttcgaccgg gcgctcgcct
    16081 ggctgacccc ggccgaccgc agggtgctcc ggctctacct cctcacccgc gtatccctgt
    16141 ggatcacggc gcacggcgcg cggtggctgt tcccccgggg cgcggagaca cgggcggcag
    16201 gcccggtcct cgcgccgttc cagcagtggg acgcgaacca ctacctccac atagcgcgcg
    16261 acggctactt cccggccgac acgggcccat gggtggaggg ttgggacaac agggaggcgt
    16321 tcttccccgg cttccccctg ctcctgcggg ccgtgcacac gatcgtcccg aactggacgg
    16381 cggcaggcct gctgatctca ctgatcgcgg gggcggtagc cgtactggcc ctgtcccgcc
    16441 tggcccgctc ctacgtcccc gaggacgccg acggcctgcg tacgaccttg ttcttcctgc
    16501 tctccccctg cgcggtcttc ctggcggccg gctacacgga ggcgctgttc ctggcgttcg
    16561 cgctcccggc ctggctggcg gcccagcgcc accactgggc gacggcggcc gcgctgacgg
    16621 cgctggcgac gacggtacgg gtcagcggtc tgttcctggc ggcggcggta gcggtgctgt
    16681 tcgtgctctc ggcccggtcg gggaagggcc ggcgcggggc gccctggctg gcactgcccg
    16741 cgctgccgcc gctggcgtac agctggtatc tgcacacccg cacgggcgac tggatggcgt
    16801 ggaagcacgc acaggagcga ggctggtacc gggacttcca caccccgtgg gaggcgtgga
    16861 cgaacacgtg gagcgcggcg ttcgacggcg tgcacgccac cgggtacgcg gccatgttcc
    16921 aggcggagtt ggtggcgatg gtggtgggcc tggccctggt cgcgctgctg gtacggcacc
    16981 gtcgcctgcc ggaggccgtg tacgtcgcgc tgagcctgtg ggcgctggga acgtcgtact
    17041 ggtacacgtc cattcctcgg gccacgctgc tgtggtggcc gctgtggatc ggcctggcgg
    17101 ccctgagcct gcgccgcccc tggttcagga cggtgtacct gtccgtggcg gccccgctgg
    17161 gcgcgctggc ggccctggcg ttcctcacgg ggcggtgggc ggggtgacgg cctcgccgca
    17221 gccgcctgcc gctgcggccg gccggtccgc ctcatcgtcc gggcaggcca ccggtggggg
    17281 agtcgacctg ccgggccacg gcgcccgctc ggctcagccc cggagtctga aggtgtcgac
    17341 gtagatcatc gcgtccgcgc tggactcgcc ggatcgcgga ccctgccgta ccggtggatc
    17401 gccgggctcg tcccacgcaa gccggcggac cggctgaccc ggtggaacga ccggccgctc
    17461 cggcggctgt atccacccga ggcggcggag gcgacgatcc tctccggcta cgccttccac
    17521 accctgccgg ccgcctgggg cgaggtgctg ggccgctctg acgcgggtgc gatgcgtcat
    17581 gtggcggccc cgtgctcacc gcgctccgcc caaccggtcc agctccagcc tcgcgggcgg
    17641 cgggagctgt tcgatgtcgg gcctggcccg gaacgattcc aacaggtagc ccaccagccg
    17701 acgggacgcc tccgcggact tcgcctgcgc gccgttgacc accccactgt tcgccagcag
    17761 ggccagcacc acgtccgaga cgtcgaagtc cgggcgcagc gcccccgcct ccttcgcccg
    17821 ccggaccagc agggccagcc cctcctccgc ccggtcgcgc tccccggcgt aactcggctc
    17881 gtccgggaag cgggccagga acgcgtgggt gaagccccgg tcggcggcct gcatcgcgga
    17941 cacctcggtg aacaccgagc agaacgcgcg ccaggggtca gggtcctcca gggcgtcgtc
    18001 gagtacgccc gcgcactccg cgagctgctc ggcgaacgcc tcggtgatca gtgaggtgcg
    18061 ggtggggaag cggcggtaga gcgtcgctac gccgacgccg gcccgccggg cgatcgcgct
    18121 gatcggtacg tcgatcccgt gcagcgcgta cgcctcccgg gccgcccgca ggatgcggtc
    18181 ccggttctcc cgggcgtcgg cgcgcagggt gtccgggccg gtgtgaggcg ggttgtgaga
    18241 gggctgagca ggcatgtctc tcactttagg gtaagtggag gggtttctcc ggttagctgt
    18301 ctagcctggg ccgggagcgg gagtacccga gggaacaggc acaggacggc ccacgatgaa
    18361 cgacatgcgc gcggcgctct acgacagcta cggaccgccc gaggtcctct acgagggccg
    18421 ggtcccggtg cccgtgcgga aacccggcga ggtgctggtc cgggttcacg cgacgagtgt
    18481 caacggcggc gagctgcacg gccgcgccgg caaggtccgg ctcgtcaccg ggcggcgctt
    18541 cccccagcgg accgggatcg acttcgcggg cgaggtcgcc gaggtggacg cctccgtcac
    18601 cggcctgcgc gagggcgacc gtgtgtgggg catcctgccg cgcgggcgga acggcttcgg
    18661 cagcgcggcc gagtacgtgt ccgtccgccc gcgccggatc gcgtacgccc ccgagaacgt
    18721 caccctgacc gaggccgtct cgctctccgc cgggggcacc acgtccctca ccgccctgcg
    18781 cgacaaggcc cggctccggg cgggcgaacg cctcctcgtc cgcggggcgt ccggcggtgt
    18841 cggcagcgtc gccgttcagc tcggcaaggc gctgggcgcc cacgtcaccg gcctcgcggg
    18901 ggcgggaaac ctcgacttcg tcagggagtt gggtgcggac gaggcgatcg accgccgcgc
    18961 gacggcgctg tcggagctgg gcccgtacga cgtcatcatg gacacggtcg gcaccgaaca
    19021 ccgcagcctg caaggcctgt tggcaccacg cggccgcctg gtctccatcg cgttcgacat
    19081 cgaccacccg gccaagggca tcggctacat cctggcgtcg gccgtccacg gcggtcgacg
    19141 ggtccgcttc ttcagtggca accccaagca cgacctgttc gccgagctgg ccgcgtacgt
    19201 cgaacgcggc gacctgcgcc ccgtcgtcga cacggtccac ccgctgtcgg gcatcgccgc
    19261 cgcccaccgc gccctggagg cgggcggggt gcgggggaag catgtgatcc gggtggtgtg
    19321 aggcgccgtg ctctccgggg catggcccct cgggttgttc ccggtcctgc cttcctggtg
    19381 ggttccgacc ggtcgtccgg aggggcggcg gagcccaggg gccttgaccg cgacgccccg
    19441 acacgggccg gggtgaccgg ggacgacggt ggccccgggg attccccccc cggggccacc
    19501 atcacggaca agggaccgcc cccctcaccc ccgctccagc ccgccccgcg ccacaacccc
    19561 cgcgtaccac cgcgcgctgt ccttcaccgt ccgccgctgc gaggcgaagt ccacgtggac
    19621 gatgccgaag cgcttgctgt agccgtacgc ccactcgaag ttgtccagca gcgaccacag
    19681 gaagtagccg cgtacgtcca ccccgtcctc gatcgcccgg tgtacggcac tcaggtgcgc
    19741 gtccaggtac gccaccctct ccgggtcgtg cacctggccc tccgggtccg cgtagtcgtc
    19801 gtacgccgct ccgttctcgg tcaccagcag cgggaggtcc gggagttcgt cgcggaggcg
    19861 ggtcaggagt tcgtagaggc cgtcggcgtc caccggccag tccatcgccg tgcgcgggcc
    19921 ctccgcgggg gtgaacgcca catgctgctc ggcgcccgcc caaggggagg gggagtcgga
    19981 gctgcccgcc gaaaccacgc tgggggagta gtagttgatc cccagggagt cgatgggggt
    20041 cgacgtcacc tccaggtcgc cgtccttcac gaacgaccag tccgtcaccg ccgccgtgtc
    20101 cgccaccagg tcctgcggca gccgcccgtg gaagaccggg tccaggaaga tccggttcgc
    20161 caccgcgtcg atcctgcgca ccgcgtcccg gtccgcgtcg gtgtcgctca gggggcgcag
    20221 ggcgtgcagg ttgagagtga gggagacctc ggccgtggac gggaggcggt cgcgcaggac
    20281 ccgggtcgcg ccgccgtggg ccaggttgaa gtggtgcgcg gcgcgcagcg cggcgaggtc
    20341 gctggtgcgg ccgggggcgt ggaccccgtt cccgtacccg aggaacgccc cgcaccaggg
    20401 ctcgttgagc gtcgtccatg tggacacccg gtcacccagc gccccggcca ccaggcccgc
    20461 gtactccgcg aaccggtgtg ccgtgtcccg ctccggccag ccgcccgcgt cctccaactc
    20521 ctgcggaagg tcccagtggt agagcgtggc gaccggtctg atcccggccc ccagcagctc
    20581 gtccaccagg cggcggtaga agtccaggcc gcgctccacc gccgggcccc ggcccgtcgg
    20641 ctggaccctg ggccaggaga cggagaaccg gtagtccgtg acgccgagct cccgcatcag
    20701 cttcacgtcc tccggcatcc ggtgcagatg gtcggcggcg atgtcaccgg tgtcgccgtt
    20761 gcgcaccttg ccgggggtac ggctgaacgt gtcccagatg gagggcgtac ggccgtcctc
    20821 cgtggcccca ccctcgatct ggtacgcggc ggtggccgtc ccccaccgga atccggccgg
    20881 gaagcggagc acctttccgg tctcggggcg ggcgcccgtg gaggtcgccg ggcgggcatc
    20941 gacagcggtc atgagacgga cactccagag gtgaggggag ggtgaggagg ggatgggcga
    21001 ggaggcggag gcgcggggtc agcccttcac cgcgccctgc atgatgccgc ccacgatctg
    21061 ccggcccagc aggccgaaga ccagcagcac cggcagcgtg cccagcagcg tgccggccat
    21121 gatcaccgac tggtcgttga catagccgcc gcccagctgc cgcagcgcga cctgcacggt
    21181 cggctcctgc gaggacagcg cgatgatcgg ccagaagaag tcgttccacg ccgtcatgaa
    21241 cgtcagcatc ccgagcaccg ccatccccgg ccgtgcgatc gggatcacga tcgaccagaa
    21301 gatccgggcc gtggaggcgc cgtccacccg ggccgcctcg atcagttcgt ccggcagcga
    21361 ctgcaccagg tactggcgca tgaagaagac gccgaaggcc gacaccaggc cgggcaggat
    21421 caccgcctgg agctggttca cccactggag ttcggcgatc agcatgaaga gcgggatcac
    21481 gcccagctgc ggcgggatca tcatcgtccc gatcgtcagc gtcagcagcg cgccccggcc
    21541 cctgaacttc agcttggcga aggcgaatcc ggcgagtgtg cagcacagga ccgtgccgag
    21601 cgtgatcgag gacgacacga tcagcgagtt cagcagcgcc ttgccgatgt ccgcctcttc
    21661 gagcaccgcg tcgaagttct tgatcaggtt cgagcccggc agcagactcg gcggcacctg
    21721 cgccatgtcc gcgttggacc ggctggccgc gacgatcgtc caatagaagg ggaacgccga
    21781 gatgaggagg gcgaagccga ggatgaggta cgagagccag ccgcccttca tcgtccggcc
    21841 cgcgcctccc ttgcgtaccc gctttcccgg cgggtcctgc ggcgggcggc ccgtctccgg
    21901 ggccgtcggc ggtgcgacga gcgcggtcat cggccggcct ccttgcgtgc acggcggcgc
    21961 gcgatcaggg cgttgacccc gacgagcacc acgatcagga cgaacatcac ccaggcgatg
    22021 gccgcggccc ggcccaggtg gaagaagccc cagccctgct cgtacatgta caggccgagg
    22081 gtctggtact ggtgcgagat gccacccgaa atcgaaccct cgaacagcag tggctcaccg
    22141 aagagctggg tcgccccgat ggtcgagatg atgaccgtga agatgatcgt ggggcgcagc
    22201 ccgggcagcg tgacgtggat gaactgccgc cagcgggagg ccccgtccat ctccgccgcc
    22261 tcgtacagct cgtgcgggat cgactgcatg cccgccaggt agatcagcgc gttgtacccc
    22321 gtccaccgcc agatcacgat cgtcgacacc gcgatctgcg aggcgaccgt gcccgtctgc
    22381 cagtccaccg ggtcgaaacc gaccagcccg atcgcgtagt tgatcaggcc gaagtcccgg
    22441 ccgaagagct gcgcgaagac cagcgtggcg gcggcgaccg atgtcgcgta cggcagcagg
    22501 atcgccgtcc ggatgaaagt ccggccgcgc agcttgtagt tgagcaggtg cgccaggccc
    22561 agcgccatcg ccagctgcgg aaccgtcgac agcacgccga tcgtgaacgt gttgcgcagc
    22621 gagatccaga agtactcgtc ggtgaagagc gccgtgtagt tggcgatgcc c
//
