LOCUS       NZ_CP032543            24801 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4020070
            Orig. end                         :: 4044871
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24801
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="17"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..24801
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24801
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14801](-)"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14801)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     misc_feature    312..326
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            1015..1458
                     /locus_tag="D6270_RS17965"
     CDS             1015..1458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513551.1"
                     /locus_tag="D6270_RS17965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109164502.1"
                     /transl_table=11
                     /translation="MSRTQWCCLTALLAILMGLLCGPMGAAPSYADASPSEGVAVTVGE
                     AVTATAPDGPAAADATAAAARAVVEAFDAGAPVPGCREPGDHDSEPAVPTRARAAYDQA
                     PGLAPWGLPAATGALPAEPPPGIRVQDPVSATPTPVQLSVLRV"
     gene            1523..2317
                     /locus_tag="D6270_RS17970"
     CDS             1523..2317
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610123.1"
                     /locus_tag="D6270_RS17970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_109164501.1"
                     /transl_table=11
                     /translation="MPTPKNTKPSSRKPLLYGAVIVVAAGLLGFASYKATAPGGSSADT
                     ATGPVAEVSADPQQGVHPELAKLARRDADDKLAAGRADAPVVLIEYADFKCGYCGKFAR
                     DTEPELIKEYVEDGTLRIEWRNFPIFGEESENAARGAWAAGQQDRFWEFHAAAYAEGAK
                     EKGFGKDRVKALAEEAGVKDLARFMKDLDGEAARAAVARDQEQGYGIGATSTPSFLING
                     RPIAGAQPKETFTQAIETAAEQAKTTAGSSSGTAGTTGDSAK"
     gene            2314..3162
                     /locus_tag="D6270_RS17975"
     CDS             2314..3162
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125814.1"
                     /locus_tag="D6270_RS17975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome c biogenesis CcdA family protein"
                     /protein_id="WP_109164500.1"
                     /transl_table=11
                     /translation="MSPDIGYFAAFLGGLLALVSPCSALLLPAFFAYSIDSTSRLLART
                     GIFYAGLATTLVPLGAAGSYAGRLFYGHRDALVTGAGWLIIVLGVAQIVGLGFASRRMA
                     ELSGRIRPTTAFSVYALGAVYGLAGFCAGPILGSVLTVAAVSGSPVYGGLLLAVYALGM
                     AVPLFVLALLWERFDLGRRTWLRGRTVQLGGRFQLHTTSLLSGLFFIGLGVLFLVYDGT
                     TALPGLLGVDSSFAVEQWAQRLGERVSDAVLLGAVVLVVLGVLGVRAWRRRVTDERAGE
                     A"
     gene            complement(3280..4242)
                     /locus_tag="D6270_RS17980"
     CDS             complement(3280..4242)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010636790.1"
                     /locus_tag="D6270_RS17980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_225976891.1"
                     /transl_table=11
                     /translation="MPRRPRLRPLAAALCLAVLALSSCANPPDAERPAAGSASAGDINK
                     EAGLQRLRTERVDAIAAQVPRAVRDRGTLEIVTFAGLAPPLSFYATDNKTVIGMEPDLG
                     RLVADVLGLKPRLHTVSWENMFVGLDSGKYDVAIANITDTEERKRTYDFASYRQDKVAF
                     EGLKGSGLRVREPRDVAGLTVAVHPGTNQEKLITQWSAENERAGRKPSEIKFYQAQSDV
                     YLALRSGRVDLYLGSNPSVAYHVADAGQTEVVGTYSGAGAGREGWIAATTRKDNGLAAP
                     LAGAINALIDDGVYGKAVARWHLTEEAVTRSRINPPGLP"
     gene            complement(4245..5033)
                     /locus_tag="D6270_RS17985"
     CDS             complement(4245..5033)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131952.1"
                     /locus_tag="D6270_RS17985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_109164498.1"
                     /transl_table=11
                     /translation="MSRWTVDMRGVHKSYGALEVLRGVDLQVRTGEVAALLGPSGSGKS
                     TLLRVLNQLERAERGHVTIDGELIGYRRSGTKLYELKEKDILRQRRKVGFVFQSFNLFP
                     HLTVLDNLVEAPLAARLAGREELRETARTLLSRVGLADKSDAYPRQLSGGQQQRVAIAR
                     ALALRPKVLLFDEPTSALDPELVDEVLDVIKDLARSGTTMVVVTHEIGFAREVADTVVF
                     MDGGVIVEQGPPSEVLDHPRHPRTRAFLSKAPLSPSPPKE"
     gene            complement(5030..6031)
                     /locus_tag="D6270_RS17990"
     CDS             complement(5030..6031)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382194.1"
                     /locus_tag="D6270_RS17990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_109164497.1"
                     /transl_table=11
                     /translation="MPRGTELPPADTAAESTRPHGGDRGPGLEPEDFEVVPARHYGRWV
                     ASLAVLVVVLQFTHGLLTNPVWEWRVVASYLLSESIVNAVGVTLQLTAYATVLGFSLGT
                     VLAFMRLSASPVLRTVAWTYIWVFRSIPMIVQLVFWFNLGALYRELGIGIPFGPVFASV
                     ESNTLIGTMGAAIIGLSLHQAAYCAEIVRGGILAVDRGQWEAAAALGIPRLRQMRRIIL
                     PQAMRSLLPTAVSEVVSLLKGTSVVYVMAIGELFYQTQVIYSRNSRVIPLLLVATAWYV
                     ALTSVLSVAQFYAERRLARGVDGAPPPSPLRRLRRLAARPEKPAAPAAGGPR"
     gene            complement(6105..7208)
                     /locus_tag="D6270_RS17995"
     CDS             complement(6105..7208)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.3"
                     /locus_tag="D6270_RS17995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_158650534.1"
                     /transl_table=11
                     /translation="MAKWPISMFPISVLLLVPPRYSYAQAGAVVAVMLLANAVSSPVRG
                     RQAARRGAGPVLRVCLAGYLAGIAGIGLCAVVGAPLPLLLGSALLMGAFFPPASILLRS
                     HWTAVDRDLGGRSSANALESALMDLSLITGPVLAGWLSTSIAPVLPLVLIGALMALAVV
                     LLTALPDRATVPSPAPEHTGRVLRAPLVMLFAAQLLFCAALAATEVSLPVYAQERNAAS
                     ASGWLLAGLSTGSIVGALALGRLHGSRLTRLPVLLALLAAGTCAVGAAMSLRPLVVALV
                     CVPAGLAIGSVFARFFTVLGTVTPPGSDHEVQGWANSMTTVGFAAGSFGGTALGEAFGT
                     TALVFCAPVLALAAAALAASARPGTTP"
     misc_feature    7171..7186
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            complement(7342..8613)
                     /locus_tag="D6270_RS18000"
     CDS             complement(7342..8613)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024925.3"
                     /locus_tag="D6270_RS18000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_109164495.1"
                     /sec_met_domain="ATP-grasp (E-value: 5.1e-06, bitscore:
                     24.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISSPALVLVDPVRQGRPFKDAARDLGFSVVSLYTHDYLASLDG
                     HADGDDLSFYTADPEEALHLVSAAGVDARAVVPCLEAGVYLTDVLAHLLGLPGNDHTLA
                     MARRNKAAMRAHAARAGVRIPEFRLVTSADDIVAAAHEIGFPVIVKPTLGAGSQGVRVY
                     STPADLEKGQPQVTHDVYREPVREWLVERYVRGREFAVNFFSADGEHRLVDLWEYLRPD
                     DADYDFPLWDIVQAGPDHPDRSRVEEYVRGVLDAFGIRRGPSHTEVKCTADGVYLIEVG
                     ARLSGGPAVDLWMAHGGLRPFHDTIACYLGRRPALLDGPVEFPARFGSSVVHNEQGPGL
                     LVAVHGAEEAAGLPGVDSVELGYAPGEHVPATHDNISIPFSAAVHGSDTDSVLATLAAI
                     RSLVRVETRPATPDDAAGTSAALT"
     misc_feature    complement(8929..8944)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     misc_feature    9172..9185
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.03"
                     /tool="antismash"
     gene            9222..9920
                     /locus_tag="D6270_RS18005"
     CDS             9222..9920
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138491.1"
                     /locus_tag="D6270_RS18005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_225976892.1"
                     /transl_table=11
                     /translation="MYTDVSGPDTPPEPAGLTSYIPSPAISVIMYGGDPLTRAGVVAQI
                     GHHRGIALLADTDRAAGGPPCEVALVLGGHLDTQSFTHLRKLGSEYGKRVVLVVGELDE
                     HRLSQVIEAGIFSIVWRHQATPASLVKAIQAAARDEGDMPGDLLRRALAHLERHSQGTV
                     LSAVAPGRPTGRELNILELVAHGLGTREIAEELNYSERTIKGVLHDAMTRLHLRNRAHA
                     VAYAIREGYM"
     misc_feature    9429..9431
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..10585)
                     /gene="folE"
                     /locus_tag="D6270_RS18010"
     CDS             complement(10001..10585)
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070065.1"
                     /locus_tag="D6270_RS18010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP cyclohydrolase I"
                     /protein_id="WP_109164494.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 4.3e-55,
                     bitscore: 184.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMNTVEPQTEAEEGPADPLVDLARRLLKEIGEDPDRDGLRQTPE
                     RFARWWREFIDYDPGTIDTLFETTTTSQMVVVSDIRVWSLCEHHLLPFNCSVDIAYRPT
                     QRLLGLSKFARVAHRHAHRLQVQERLVADIAQEVADITGAEDVAVIAKGEHLCMTMRGI
                     KASAEMTSTAFLGAFGDDSSLRGELFALLRS"
     gene            complement(10586..11236)
                     /locus_tag="D6270_RS18015"
     CDS             complement(10586..11236)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577817.1"
                     /locus_tag="D6270_RS18015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_204117097.1"
                     /sec_met_domain="QueE (E-value: 3.1e-67, bitscore: 225.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-09, bitscore: 35.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.5e-10, bitscore: 40.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRRCGFLRLGGCNLSCRWCDTPYTWDWQGISDSGVRYDPKVELH
                     RRSVPSVAEELLGLGVGLVVISGGEPLSQQVRLLPLIDTLLEAGVEVEFETNGTRVPDG
                     RLVRPGVRFNVSPKLSHSGDPAERRIVPQALRRFAVTPGVTFKFVCRTTADLDEVAALV
                     DDFALESVWIMPEGQDPDAIDKHMQEIVSSVIDRGWNVTTRLHTLVWGHKRGV"
     gene            complement(11372..11734)
                     /gene="queD"
                     /locus_tag="D6270_RS18020"
     CDS             complement(11372..11734)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122989.1"
                     /locus_tag="D6270_RS18020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-carboxytetrahydropterin synthase QueD"
                     /protein_id="WP_109164493.1"
                     /sec_met_domain="PTPS (E-value: 2.3e-34, bitscore: 116.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRITKRFDFSASHRLGGLPESHQCARLHGHNYAVELELSAERS
                     ALTATGFVRDYGELSVFKKWLDDTLDHRHLNDVVEGNPTAENLAVWMFEQWKADFPELS
                     SVRISETPKTWAEYRP"
     gene            complement(11799..12800)
                     /locus_tag="D6270_RS18025"
     CDS             complement(11799..12800)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2OG-FeII_Oxy"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034427.1"
                     /locus_tag="D6270_RS18025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein"
                     /protein_id="WP_109164492.1"
                     /sec_met_domain="2OG-FeII_Oxy (E-value: 2.7e-10, bitscore:
                     39.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSAVPVVDLGGWRTASAAEREETAAALDRGLRDTGMFLLTGHGV
                     PETAMQELRARGREFFALPSEAKRPYAIGAPYESGWLEMHPGGGVGVPRAEGAEAAAPP
                     DLHESFYSGPSYRSGDEALDRYCYPPNRWPDGELPGLRRAVETYTDHMRRVAQALNELF
                     AQVLGLPGDFFTSRATRATWTQNVSWYPSLASVGTVASGQLRNGPHTDLGAFTILSRQL
                     GVGGLQAWNETAGWFAPPHRPDALVVNLGDLMERWTDGRWRALRHRVLAPSPSAPDEEL
                     LSLVFFYESDPGTRIDPLSPPVGGGAGLEPVVSRHSVLAKLGVHLEATAFPA"
     misc_feature    complement(12705..12707)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12830..14092)
                     /gene="ectB"
                     /locus_tag="D6270_RS18030"
     CDS             complement(12830..14092)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (21-352). E-value: 4.7e-69.
                     Score: 224.9. Matches aSDomain:
                     nrpspksdomains_D6270_RS18030_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084079.1"
                     /locus_tag="D6270_RS18030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_109164491.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6.6e-70, bitscore:
                     234.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVFEELESEVRSYSRAWPVVFDRARGSWLYDEDGNRYLDFFTGA
                     GALNYGHNPPVLKRALMDYLSRDGVAHSLDMFTVARRHFLKALQETVLAPRNLDYRVVF
                     PGPGGANAVEAALKLARRVTGRSTVVHFTNSFHGMTLGALAVSGNAAKRAAAGIPLTHG
                     VALPYDGYADGSPELLDRLIGDPGSGLDRPAAVIVETVQGEGGVRAASAPWLRTLAEVC
                     RRHEVLLVVDDVQMGCGRTGPFFSFEDAGITPDMVCLSKSIGGYGLPLALTLIRPELDV
                     WQPGEHNGTFRGVGPAFVTGAAALRAYWSGNDLEKAVRRSGECLAAGLGEIADRYEGAG
                     LHVTGRGLAAGLGIPGPAGDGSGGEAAAVSTAAFRRGLLVETSGADSSVVKLLPPLTVT
                     ESELKEGIDILASAVDAVLGA"
     aSDomain        complement(13037..14029)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS18030_Aminotran_3.1"
                     /evalue="4.70E-69"
                     /label="D6270_RS18030_Aminotran_3.1"
                     /locus_tag="D6270_RS18030"
                     /protein_end="352"
                     /protein_start="21"
                     /score="224.9"
                     /tool="antismash"
                     /translation="FDRARGSWLYDEDGNRYLDFFTGAGALNYGHNPPVLKRALMDYLS
                     RDGVAHSLDMFTVARRHFLKALQETVLAPRNLDYRVVFPGPGGANAVEAALKLARRVTG
                     RSTVVHFTNSFHGMTLGALAVSGNAAKRAAAGIPLTHGVALPYDGYADGSPELLDRLIG
                     DPGSGLDRPAAVIVETVQGEGGVRAASAPWLRTLAEVCRRHEVLLVVDDVQMGCGRTGP
                     FFSFEDAGITPDMVCLSKSIGGYGLPLALTLIRPELDVWQPGEHNGTFRGVGPAFVTGA
                     AALRAYWSGNDLEKAVRRSGECLAAGLGEIADRYEGAGLHVTGRGLAAGL"
     gene            complement(14094..14801)
                     /locus_tag="D6270_RS18035"
     CDS             complement(14094..14801)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070068.1"
                     /locus_tag="D6270_RS18035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-cyano-7-deazaguanine synthase"
                     /protein_id="WP_109164490.1"
                     /sec_met_domain="QueC (E-value: 1.9e-43, bitscore: 146.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIIAVVSGGIDSVTMAYHLRAQGHELHLLGIDYGQRHRRELAC
                     ARLAAERLGAPYEEADLGGARGVLRGSSLTDPALDVPVEGAGSSGAAAVPGRPNIVPNR
                     NALLLSAAFALAVVERAEAVAFGIMAEDVGPSDTSLEFLDAFLAMERIGTRGHAHPDLD
                     LIAPLASMLKREVIALGHRLSVPFADTWTCFRGEELHCGRCASCVERRGAFEAAGIHDP
                     TVYAASAVTVEGA"
     gene            complement(14875..15249)
                     /locus_tag="D6270_RS18040"
     CDS             complement(14875..15249)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D6270_RS18040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_151414699.1"
                     /transl_table=11
                     /translation="MLRPGGTVVYLGIGERDVQSLKEVFGRGQLYGRWSGEPVVRQERR
                     RLEDAGLTVEEEREFSYDEFFHTPADLDRFLQMVPIFEDYDSATDRRSFERYAAQATTP
                     EGIHLARHWFVLCARRPAQG"
     gene            complement(15186..15641)
                     /locus_tag="D6270_RS18045"
     CDS             complement(15186..15641)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025217.3"
                     /locus_tag="D6270_RS18045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_158650535.1"
                     /transl_table=11
                     /translation="MTQRQEFYSKVAEKFGGYSSGAQRTTSFPQGDPEEHFDSLVREHG
                     SPTARLLDVGCADGRNVLAVAPAFGRVEAIDLSAEMLASAERHRAGSGLDHVAFTVGDA
                     SATGFPDQTFDVVTSRRGPLFPRSSTACCGPGARWCTWASGSGTSSR"
     tRNA            complement(15972..16045)
                     /anticodon=(pos:complement(4036079..4036081),aa:Phe,
                     seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="D6270_RS18050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Phe"
     gene            complement(15972..16045)
                     /locus_tag="D6270_RS18050"
     tRNA            complement(16068..16142)
                     /anticodon=(pos:complement(4036175..4036177),aa:Asp,
                     seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="D6270_RS18055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asp"
     gene            complement(16068..16142)
                     /locus_tag="D6270_RS18055"
     tRNA            complement(16181..16253)
                     /anticodon=(pos:complement(4036287..4036289),aa:Glu,
                     seq:ttc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="D6270_RS18060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Glu"
     gene            complement(16181..16253)
                     /locus_tag="D6270_RS18060"
     gene            complement(16334..17944)
                     /locus_tag="D6270_RS18065"
     CDS             complement(16334..17944)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447484.1"
                     /locus_tag="D6270_RS18065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_109164488.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.5e-09, bitscore:
                     35.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRAPFRAAADRVRHRLTQLVRPDSAKSPKRPARRPATGDLMGTA
                     TPRPFVRALAMLAVVVIGAWLGLLAVGSIRTPVGPMDTNMTLRPSLTGGSKINVSPLGA
                     LELDSHIAPLRLDVNVDRLDPVRSQALVDQPERFSGLQDEVTRDVAAGTRELAVRSCVA
                     VISGATALGLVVYRRPRRALAAGGLALTLLAASGVSAYATWNPKSVLEPKFSGLLSSAP
                     SLVGDARSIVTEFDIYQQELARLVTNVTRLYDATSTLPVYQPDPGTIRALHVSDIHLNP
                     AAWHIIASLVKQYEIDVIIDSGDTMDHGSAAENGFLDPIRDLGAPYVWVRGNHDSKVTQ
                     AYLEKVRNVRVLDNGRTVDVAGLRIAGTGDASFTPDRTKPVGGKAAAELQGMRLASALR
                     DQEQAGTPVDIAVAHDPNTARQTDGTVPLVLAGHVHHRVNEQLKGGTRLKVEGSTGGGG
                     LRAVQNDKPEKVRASVLYLDRETRRLQAWDEITLGGLGLTTAEVSRHLPEENLKGESPA
                     SPSPSPSPTGSATRPTPSP"
     gene            18101..18451
                     /locus_tag="D6270_RS18070"
     CDS             18101..18451
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566395.1"
                     /locus_tag="D6270_RS18070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallopeptidase family protein"
                     /protein_id="WP_204117096.1"
                     /transl_table=11
                     /translation="MLEMTREQFEELVSQALDRIPPELMRLMDNVAVFVEDEPEPGDPE
                     LLGLYEGTPLTDRGEWYAGVLPDRITIYRGPTLRMCETHEDIVAETEITVVHEIAHHFG
                     IDDERLHALGYG"
     gene            18448..18924
                     /gene="crcB"
                     /locus_tag="D6270_RS18075"
     CDS             18448..18924
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968055.1"
                     /locus_tag="D6270_RS18075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_109164487.1"
                     /transl_table=11
                     /translation="MSEQAPDELPEPGPPSASQPRVLGAVAAGGALGALARYAALVRWP
                     AAEGGFPWTVFVVNVTGCALIGVLMVVTVERGRVTHPLLRLFLGVGVLGGFTTFSTYAA
                     DVSGLLVRQELPTAVAYMATTVVAALAAVWAGAVVTRRLLDRGARGGRGGERAA"
     gene            18921..19295
                     /gene="crcB"
                     /locus_tag="D6270_RS18080"
     CDS             18921..19295
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968056.1"
                     /locus_tag="D6270_RS18080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_109164486.1"
                     /transl_table=11
                     /translation="MNWFLVVIGGAVGAPLRYLTDRAVQANQGRGVAYVFPWGTFTANA
                     AGSLILGVLTGAAVSSSASALLATGLCGALTTYSTFSYETLRLAETGRSFLAVANVVAS
                     LLMGLGAVFLGAELAGGFGG"
     gene            19526..20116
                     /locus_tag="D6270_RS18085"
     CDS             19526..20116
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610129.1"
                     /locus_tag="D6270_RS18085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_151414701.1"
                     /transl_table=11
                     /translation="MRKLSAPVRWAAVTALTIAASTGCMSVGDDGARPSPSGSSDSKGR
                     TADPDDETTAGSGEAGHRGGDAHTHSDGDSADRKNPKGKPSPEASGSAVPSDTPKGARP
                     QPGVPHPPRPGQPAAPTPSTPGPGEPPPVVPEPPAPQPSPDPDPDPEPEPTEPSEPPPS
                     ASPAAQLRTQSMGGTGEGRPLRTPEASPQVRPV"
     misc_feature    20315..20327
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    complement(20342..20357)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.35"
                     /tool="antismash"
     gene            20356..22662
                     /locus_tag="D6270_RS18090"
     CDS             20356..22662
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125788.1"
                     /locus_tag="D6270_RS18090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_151414702.1"
                     /transl_table=11
                     /translation="MPENIDNAELAELVEAAVTEAPAGATAAAGKAPVAEKAAEKSVAD
                     FITEDKPAAKAEAPAKTEAAAEAETDEAPVAETDAEPTITFGDLGLPDGIVRKLAQNGV
                     TAPFPIQAATIPDALAGKDILGRGRTGSGKTLSFGLPLLASLSGGATEKKKPRGIILTP
                     TRELAMQVADALQPYGDVLGLKMKVVCGGTSMGNQIYALERGVDVLVATPGRLRDIINR
                     GACSLENVQVAVLDEADQMSDLGFLPEVTELLDQIPGGGQRMLFSATMENEIGTLVKRY
                     LSNPVTHEVDSAQGNVTTMSHHVLVVKPKDKAPVTSAIAARKGRTIIFVRTQLGADRIA
                     EQLIESGVKADALHGGMTQGARTRVLEDFKKGYVNALVATDVAARGIHVDGIDLVLNVD
                     PAGDHKDYLHRSGRTARAGKSGVVVSLALPHQRRQIFRLMEDAGVDASRHIVQGAGVFE
                     PEVAEITGARSLTEVQADSANNAAKQAEREAADLTKQLERVQRRAVELREEADRLVARA
                     ARERGDDPEAAVAEVTAEAEAALVAAISVPEQPAAREEQRRDERGNYERRDNRGGDRGG
                     YRGGNDRRDDRPSGGFRSGGDRRDDRGGRPFERRDNDRPSFNRDRRDDRPSGGFRSGGD
                     RRDDRGGRPFERRDNDRPSFNRDRRDDRPSGGFRSGGDRRDDRGGRPFERRDNDRPSFN
                     RDRRDDRPSGGFRSGGSDRPFNRDRRDDRPSGGFRSGGSDRPTGRRDDHRGANTGTNTG
                     TFGRRDDKPRWKRNG"
     tRNA            22914..22990
                     /anticodon=(pos:4043018..4043020,aa:Lys,seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="D6270_RS18095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Lys"
     gene            22914..22990
                     /locus_tag="D6270_RS18095"
     tRNA            23239..23312
                     /anticodon=(pos:4043343..4043345,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="D6270_RS18100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            23239..23312
                     /locus_tag="D6270_RS18100"
     gene            23416..24162
                     /locus_tag="D6270_RS18105"
     CDS             23416..24162
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047367.1"
                     /locus_tag="D6270_RS18105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_109164483.1"
                     /transl_table=11
                     /translation="MEWSIQEIARKAGTTSRTLRHYGELGLLVPSRVGSNGYRYYDQDA
                     LVRLQRILLLRELGLSLPAIKGVLEGQRDTAVALRAHLRLLEQEQARIGRRIASVRTTL
                     HRTQEGMELMAEEVFDGFDHTAHEREVTERWGREAYEEGDRWWRSLGERGKRAFRDEHE
                     AIARDWGAAKEAGVGAGSDVAQEIARRHCAWLSTTVAPSRSYVIGLGEMYVADPRFGKN
                     YDRYGDGTAAFVRDALTIYAGQRLSG"
ORIGIN
        1 gtcgcagatc gcggtgatct ggtcgcggtc ggagtcctcg ctgtcgtcct cgaggagggg
       61 gcggtacctg acctccaccg gatacgtccg gccgctgacc tccacgatcg gcgcctcgcc
      121 gaagtggcgc gcgaaccgct ccgggtcgat ggtcgccgag gtgatgacga ccttcagatc
      181 cgggcgcttg ggcagcagcc gggccagata gccgagcagg aagtcgatgt tcagcgaccg
      241 ctcgtgggcc tcgtcgatga tgatcgtgtc gtacgccagc agctcgcggt ccgtctggat
      301 ctcggcgagc aggatgccgt cggtcatcag cttcagatac gtcgactccg ggttcacctg
      361 gtcggtgaag cggaccttcc agccgacggt ctcgcccagc ggcgtcttca gctcgtccgc
      421 gacgcgctcc gcgaccgtac gggcggcgat ccggcggggc tgggtgtggc cgatcatgcc
      481 ccggacgccg cgccccagct ccatacagat cttggggatc tgcgtggtct tcccggaccc
      541 ggtctcaccg gcgacgatca cgacctggtg gtcgcgtatc gcctccagga tctcgtcctt
      601 cttctggctg acgggcagct cttccgggta cgacagggcc ggcagccggg ccgcgcgggt
      661 cgcgagccgt tcggccgcct tgcccgcctc ggccgcgatc tcgtccagca cggactggcg
      721 ggcctcgggc ttgcggatgc ggcgcgctcc ttcgaggcgc cggccgagcc ggttcgcgtc
      781 acggagcgag agctgtccga gctgggactg gagatcggcg aaggaagtag acatacggat
      841 cccaggatct cacccggcgg tcaggagtgg cgacctcatt tcgcgcggac tgcgtcacgc
      901 gggggcggcc cgggagcgcg ggcgcccggt gaccgatgcg gcgggcgtgg tcacggcgcg
      961 taccatttcg ggcagtcgaa cgctcagtct ccccgcacga aaggcgccgg tcccgtgtcc
     1021 cgtacgcagt ggtgctgcct gacggcgctg ctcgcgatcc tgatggggct gctgtgcgga
     1081 ccgatgggcg cggctccttc ttatgctgac gcgtcaccct ccgagggtgt cgcggtcact
     1141 gtcggggagg cggttacggc gacggcaccg gacggcccgg ccgctgcgga tgccacggcc
     1201 gccgccgcgc gggccgtcgt ggaggccttc gacgcgggcg ccccggtccc cggctgccgg
     1261 gagcccggcg accacgacag cgagcccgcc gtgccgaccc gggcccgtgc cgcctacgac
     1321 caggcccccg gcctcgcccc ctgggggctg cccgccgcga cgggcgccct gccggccgag
     1381 ccgccgccgg ggatacgggt ccaggacccg gtctccgcca caccgacccc cgtacagctc
     1441 tccgtgctga gggtgtaggc ctggcgaccc gcccgacccg cacccttccc tctcctcccg
     1501 caccaccagc acggagtgcc gcatgcccac gcccaagaac accaagccct cctcccgcaa
     1561 gcccctcctc tacggcgccg tgatcgtcgt cgccgccggt ctcctcggct tcgcctccta
     1621 caaggcgacc gcacccggcg gctcctcggc ggacaccgcc accggcccgg tcgccgaggt
     1681 ctccgccgac ccgcagcagg gcgtccaccc ggagctcgcg aagctggccc gccgcgacgc
     1741 cgacgacaag ctggcggccg gccgcgccga cgcccccgtc gtcctgatcg agtacgccga
     1801 cttcaagtgc ggttactgcg gcaagttcgc ccgggacacc gagcccgagc tgatcaagga
     1861 gtacgtcgag gacggcaccc tgcgcatcga gtggcgcaac ttcccgatct tcggcgagga
     1921 gtccgagaac gccgcccgtg gggcctgggc cgccgggcag caggaccgct tctgggagtt
     1981 ccacgcggcc gcctacgccg aaggggcgaa ggagaagggg ttcggcaagg accgggtcaa
     2041 ggccctcgcc gaggaggccg gggtcaagga cctggcccgt ttcatgaagg acctggacgg
     2101 cgaggccgcc cgcgccgccg tcgccaggga ccaggagcag ggttacggga tcggcgccac
     2161 gtccaccccg tcgttcctga tcaacggccg cccgatcgcg ggggcgcagc cgaaggagac
     2221 gttcacgcag gccatcgaga cggcggcgga acaggcgaag accaccgccg ggagctcctc
     2281 cggcacggcg ggcaccaccg gggactccgc caagtgagcc cggacatcgg ctacttcgcg
     2341 gccttcctcg gcgggctgct cgccctggtc agcccgtgca gcgcgctgct gctcccggcc
     2401 ttcttcgcgt actccatcga ctccacctcg cgcctgctgg cccgtaccgg catcttctac
     2461 gccggtctcg ccaccaccct cgtcccgctc ggggcggccg gttcgtacgc ggggaggctc
     2521 ttctacggcc accgcgacgc cctggtgacg ggcgcgggct ggctgatcat cgtgctcggg
     2581 gtcgcacaga tcgtcggcct gggcttcgcg tcgcgccgta tggccgagct cagcggccgc
     2641 atccgcccca ccaccgcctt ctccgtctac gccctgggcg cggtctacgg cctggcgggc
     2701 ttctgcgcgg gcccgatcct cggcagcgtc ctcaccgtgg cggcggtcag cggcagcccg
     2761 gtctacgggg gcctgctgct ggcggtctac gcgctcggga tggcggtccc cctcttcgta
     2821 ctcgccctgc tctgggagcg gttcgacctg ggccgccgca cctggctgcg cggccggacc
     2881 gtccagctcg gcggccgatt ccagctgcac acgacctcgc tgctctcggg cctgttcttc
     2941 atcggcctgg gcgtgctctt cctcgtctac gacgggacga ccgcgctccc cggactgctc
     3001 ggggtcgaca gctcgttcgc ggtggagcag tgggcgcaga ggctgggcga gcgggtgtcg
     3061 gacgcggtgc tgctgggggc tgtggtgctg gtggtgctgg gggttctcgg cgtacgggcc
     3121 tggcggcgac gcgtgaccga cgagagggcc ggggaggcgt gagaacggag gcgcgcacac
     3181 tgtcccggcc ggcggcacca gccgggtgca cgacgggcct cgcgcaaccg gccggtggga
     3241 agcggggtcc cggccggtgt ccgcacccct acggcaccgc tacgggaggc cgggcgggtt
     3301 gatccgtgag cgggtcaccg cctcctccgt gaggtgccag cgggcgaccg ccttgccgta
     3361 gacgccgtcg tcgatcagcg cgttgatcgc accggccagc ggggccgcca gcccgttgtc
     3421 cttcctggtc gtggcggcga tccagccctc ccgcccggcg cccgcgcccg agtaggtgcc
     3481 gaccacctcg gtctgcccgg cgtcggccac gtggtacgcc acggaggggt tggagccgag
     3541 gtacagatcg acccggccgg agcgcagagc cagatagacg tcactctggg cctggtagaa
     3601 cttgatctcg ctgggcttgc ggcccgcccg ctcgttctcc gcgctccact gggtgatcag
     3661 cttctcctgg ttggtaccgg ggtggaccgc gaccgtcagc ccggccacgt cccggggttc
     3721 ccgcacgcgc aggccgctcc ccttcagccc ctcgaaggcc actttgtcct ggcggtagga
     3781 ggcgaagtcg tacgtgcgct tgcgctcctc ggtgtcggtg atgttggcga tggccacgtc
     3841 gtacttgccg ctgtccaggc cgacgaacat gttctcccag gacaccgtgt gcagcctggg
     3901 cttcagcccc agcacgtcgg cgacgaggcg tccgaggtcc ggctccatgc cgatgaccgt
     3961 cttgttgtcg gtggcgtaga agctcagcgg aggggccagc ccggcgaagg tcacgatctc
     4021 cagcgtcccc cggtcccgga cggcccgggg cacctgtgcc gcgatcgcgt cgacccgctc
     4081 cgtgcgcagc cgctggagcc ccgcctcctt gttgatgtcg cccgcggacg ccgagccggc
     4141 ggcggggcgc tcggcgtccg gggggttggc acaggaggac agggcgagga cggccaggca
     4201 cagggcggcg gccagagggc ggaggcgggg gcgacggggc acagtcattc cttgggggga
     4261 gacggggaga gcggggcctt ggagaggaac gctcgggtac gggggtgccg cggatggtcc
     4321 aggacctcgg aaggagggcc ctgttcgacg atcacgccgc cgtccatgaa gacgaccgtg
     4381 tcggccacct cgcgcgcgaa cccgatctcg tgcgtcacca cgaccatcgt ggttccggac
     4441 cgggccaggt ccttgatcac gtcgagtacc tcgtcgacca gctcggggtc gagggccgag
     4501 gtcggctcgt cgaacaggag gaccttcggc cgcagggcga gagcccgcgc gatcgccacc
     4561 cgctgctgct gtccaccgga cagctggcgg gggtacgcgt cggacttgtc ggcgaggccg
     4621 acccgggaca gcagcgtccg tgccgtctcc cgcagttcct cccgcccggc caggcgggcg
     4681 gcgagcggcg cctccacgag gttgtccagg acggtgaggt gcgggaagag gttgaagctc
     4741 tggaagacga agcccacctt ccggcgctgc cggaggatgt ccttctcctt cagctcgtac
     4801 agcttggtgc cggacctgcg gtagccgatc agctcgccgt cgatggtgac gtggccgcgt
     4861 tcggcccgct ccagctggtt caggaccctg agcagcgtgg acttgcccga ccccgagggg
     4921 ccgaggaggg cggccacctc gccggtgcgg acctggaggt ccaccccgcg cagcacttcg
     4981 agtgcgccgt agctcttgtg gacgccgcgc atgtccacgg tccaccggct catcggggcc
     5041 ctcctgcggc cggggcagcc ggtttctccg ggcgggcggc gaggcgccgc agacggcgga
     5101 gcggggaggg cgggggcgcc ccgtccaccc cgcgggccag gcgccgttcc gcgtagaact
     5161 gggccaccga caggaccgag gtcaaggcca cgtaccaggc ggtggcgacg agcagcaggg
     5221 ggatcacccg gctgttgcgg ctgtagatca cctgcgtctg gtagaacagc tcgccgatgg
     5281 ccatcacata gaccacggag gtgcccttca gcaggctgac gacctcgctg acggcggtgg
     5341 ggagcaggga gcgcatggcc tgcggcagga tgatgcgccg catctgccgc agccggggga
     5401 tgccgagcgc cgccgcagcc tcccactgac cgcggtccac ggcgaggatg ccgccgcgca
     5461 cgatctccgc gcagtacgcg gcctggtgca gggacagccc gatgatggcg gctcccatcg
     5521 tgccgatcag cgtgttgctc tccaccgacg cgaagaccgg gccgaagggg attccgatgc
     5581 ccaactcccg gtacagcgcg cccaggttga accagaagac cagctggacg atcatcggga
     5641 tggagcggaa gacccagatg taggtccagg cgaccgtccg caggacgggg ctggcggaca
     5701 gccgcatgaa ggcgagcacc gtgcccaggg agaagcccag caccgtggcg tacgcggtga
     5761 gctggagggt gacgcccacg gcgttcacga tcgactcgga cagcaggtac gaggcgacga
     5821 cccgccactc ccagaccggg ttggtcagca ggccgtgggt gaactggagc accaccacca
     5881 ggacggcgag ggacgcgacc caccggccat agtgccgggc gggcaccacc tcgaagtcct
     5941 ccggttcgag gccgggcccg cggtcgccgc cgtgggggcg cgtactctcc gccgccgtgt
     6001 ccgccggcgg gagctcggtt ccacgtggca tgggcatcct ccttctcatc tgtggtgggt
     6061 acggagcacc ggggccaccc cgggcggggg cgtccggtga ggtctcaggg ggtggtcccg
     6121 gggcgggcgg aggctgccag cgcggctgcg gccagagcca ggaccggggc gcagaacacg
     6181 agcgccgtcg tcccgaacgc ctcccccaga gcggtcccgc cgaaggagcc ggcggcgaag
     6241 ccgaccgtgg tcatgctgtt cgcccacccc tggacctcgt ggtcggagcc gggcggggtc
     6301 accgtgccga ggacggtgaa gaagcgggcg aagacggagc cgatcgccag gcccgcaggg
     6361 acgcagacca gggcgaccac cagcggccgg agggacatcg ccgcgccgac ggcgcacgtc
     6421 ccggcggcca gcagcgcgag gagcacgggg agccgggtga ggcgggagcc gtgcagccgg
     6481 ccgagggcca gcgcgccgac gatgctgccc gtggagagac ccgccaggag ccagccgctc
     6541 gcggaggcgg cgttccgctc ctgcgcgtag acgggcaggg acacctcggt ggcggccagg
     6601 gccgcgcaga agagcaactg cgcggcgaac agcatgacca gcggcgcccg caggactctg
     6661 ccggtgtgct cgggtgccgg cgacggcacg gtcgcacggt cgggcagcgc ggtcagcagg
     6721 accaccgcga gcgccatcag cgcgccgatg aggacgaggg ggaggacggg ggcgatggag
     6781 gtgctgagcc agccggccag cacggggccc gtgatcagcg acaggtccat cagcgcggat
     6841 tcgagggcgt tggcggagga ccggccgccc aggtcgcggt cgaccgcggt ccagtgggag
     6901 cgcagcagaa tgctggcggg tgggaagaac gcgcccatca gcagggccga acccaggagg
     6961 agaggcagag gggcgccgac cacggcgcag aggccgatcc cggcgatgcc ggcgagatag
     7021 ccggccaggc agactcggag caccgggcct gccccgcgcc gcgccgcctg ccggccgcgg
     7081 accgggctgc tgaccgcgtt ggccagaagc atgacggcta cgacggcacc cgcctgggcg
     7141 taggagtagc ggggtgggac gagcagcagc acgctgatcg ggaacatgct gatcggccac
     7201 ttggccatga ggctggccag ggccagccgc ggggcgccgg gcgaggccag taccgcgcgg
     7261 tagggggcca ggagacggcc gcggggaagc gctggggtgt ccgcggccgt cggccggtca
     7321 cgggggtccg gtcccggcac gtcaggtgag ggccgcggag gtgccggcag cgtcgtcggg
     7381 tgtggcggga cgggtctcca cccgtaccag cgaccggatg gcggccaggg tcgcgaggac
     7441 gctgtcggtg tcgcttccgt ggacggccgc gctgaacggg atgctgatgt tgtcgtgggt
     7501 ggccgggaca tgttcgccgg gtgcgtagcc gagttccacg ctgtcgaccc cgggcaggcc
     7561 ggcggcctcc tccgcgccgt gcaccgcgac gaggaggccg ggcccctgct cgttgtgtac
     7621 gacggaggag ccgaagcggg ccgggaactc cacgggaccg tcgagcaggg cggggcggcg
     7681 gccgaggtag caggcgatgg tgtcgtggaa ggggcgcagc cctccgtgcg ccatccacag
     7741 gtcgacggcg gggccgccgg agagccgggc ccccacctcg atcaggtaga cgccgtcggc
     7801 ggtgcacttg acctcggtgt ggctggggcc ccggcggatg ccgaaggcgt ccaggacgcc
     7861 gcggacgtac tcctccacac gtgagcggtc cgggtggtcc ggcccggcct gcacgatgtc
     7921 ccagaggggg aagtcgtagt cggcgtcgtc ggggcgcagg tactcccaca ggtccacgag
     7981 ccggtgctcc ccgtcggcgc tgaagaagtt gacggcgaac tcccgtcccc gcacgtagcg
     8041 ttcgaccagc cattcgcgga ccggttcccg gtagacgtcg tgggtgacct ggggctgccc
     8101 cttctccagg tcggcggggg tggagtagac gcgtacgccc tgcgacccgg cgcccagcgt
     8161 cggcttgacg atcaccggga acccgatctc gtgggccgcc gccacgatgt cgtcggccga
     8221 tgtgaccagc cggaactcgg gtatgcggac cccggcccgc gcggcgtgcg cccgcatcgc
     8281 cgccttgttg cgccgggcca tggcgagggt gtggtcgttg ccgggcagcc ccagcaggtg
     8341 tgccaggacg tcggtgaggt acaccccggc ctccaggcag ggcaccacgg cccgggcgtc
     8401 gacgcccgcg gcgctgacga ggtggagggc ctcctccggg tcagcggtgt agaaggacag
     8461 gtcgtcgccg tcggcgtgcc cgtccaggga ggccaggtag tcgtgggtgt agagggagac
     8521 gacggagaaa ccgagatcac gggcggcgtc cttgaacggc cggccctgac gcaccgggtc
     8581 caccaggacg agcgcgggtg agctgatggt catggagccc tctcctcggt aggcggcctg
     8641 ccgtccttgc cgggggcggc cgggtctcac cgtccatgtt tccggctggc acgtggcggc
     8701 gacatggacc gccagacggt tcgtacggac atcggagggg ccgaacgtgc aggcgttccg
     8761 cccggtcggc ggggagcggg gagggagtgg cgccctggtg tcggcttctc cgtcgagctg
     8821 tccggatcgc gacagtgact ccggagaggg ggaggggtga caacgctgtc ttgaaaaggc
     8881 cccggaggat cagggctacg ggaagtttcc tctccctttt cgccacgcct tcacatctgt
     8941 gattctgggt gggattaaaa aaggaatgaa tggcggagtg tccatctttc ctttgattga
     9001 gaggtttgcc tggagggtgc ctgccgttca cctgctttac ctcacgtcag cgaggtgaag
     9061 tgaactttcg gacaccttcc gagcagttca cgtcaacatg gccgcgcgac gtggctccgt
     9121 ccgacgaaca cgctccggtc tggatctacg ctctgcggtc atgacggggg tcaaccgctc
     9181 gtatgcagtg aaggacgaaa atgtctcggc cttatcccag cttgtacacc gatgtatccg
     9241 gccccgacac ccctccggag ccggccgggc tcacctcgta cataccgtcg ccggccatct
     9301 ccgtgatcat gtacgggggc gaccccctca cccgagcggg cgtcgtggcc cagataggac
     9361 accaccgggg catagccctg ctggcggaca cggatcgcgc tgccggaggg ccgccgtgcg
     9421 aggtcgcgtt agtcctgggc ggccatctgg acacccagtc cttcactcat ctgcgaaagt
     9481 tgggttccga atacggaaaa cgtgtcgtcc tggtcgtcgg cgaactcgac gaacaccgcc
     9541 tgagccaggt gatcgaggca gggatcttct ccatcgtctg gcgccaccag gccaccccgg
     9601 cgagtctggt gaaagcgata caggcggcgg cccgggacga gggggacatg cccggagacc
     9661 tgctgcgcag ggcgctggcc cacctcgaac gccactccca gggaactgtg ctgagcgccg
     9721 tcgcgcccgg tcgtccgacc gggcgcgagc tgaacatcct ggaactggtc gcgcacggac
     9781 tcggcacgag ggagatcgcc gaagagctca actactccga gcgcaccatc aagggcgtcc
     9841 tgcacgacgc catgactcgc ctgcacctgc gcaaccgcgc gcacgccgtg gcctacgcga
     9901 tccgcgaagg ctacatgtga cgtacgcgga ccggcgccgg ccccaccgga cctcaggggc
     9961 cagggcgagg accgacgccg atcggcggag cgccgcagcc tcaggaccgc agtagcgcga
    10021 acagctcacc gcgcagcgaa ctgtcgtccc cgaaggcccc cagaaacgcc gtggaggtca
    10081 tctcggcgct cgccttgatg ccgcgcatcg tcatgcacag gtgctccccc ttggcgatga
    10141 ccgcgacgtc ctcggcgccg gtgatgtccg ccacctcctg ggctatgtcg gccaccagcc
    10201 gctcctgcac ctggagccgg tgcgcgtggc ggtgggcgac ccgcgcgaac ttcgacagcc
    10261 ccagcagccg ttgggtggga cggtaggcga tgtccacgga gcagttgaac ggcaggagat
    10321 ggtgctcgca cagcgaccac acccggatgt cggagaccac caccatctgg ctggtggtcg
    10381 tggtctcgaa gagtgtgtcg atggtcccgg ggtcgtagtc gatgaactcg cgccaccagc
    10441 gggcgaaccg ctcgggggtc tggcgcagac cgtcccggtc ggggtcctcg ccgatctcct
    10501 tgagcaggcg ccgcgcgaga tccaccaggg gatcggccgg gccttcctcg gcctcggtct
    10561 gcggttcgac ggtgttcatg gtcattcaga cacctctctt gtggccccag accagcgtgt
    10621 gcagccgggt ggtcacgttc catccccggt cgatgaccga ggagacgatc tcctgcatgt
    10681 gcttgtcgat ggcgtcgggg tcctggccct cgggcatgat ccagaccgat tcgagggcga
    10741 agtcgtcgac cagtgcggcc acttcgtcca ggtccgccgt ggtgcggcag acgaatttga
    10801 aggtcacccc cggcgtgacg gcgaaccgcc gcaacgcctg cgggacgatg cggcgttcgg
    10861 ccgggtcacc ggagtgcgac agcttgggcg agacgttgaa acgcacgccc ggccgcacca
    10921 gccgaccgtc ggggacgcgt gtcccgttgg tctcgaactc cacctccacg cccgcctcca
    10981 gcagcgtgtc gatcagcggg agcaggcgca cctgctggct gagcggctcg cccccggaga
    11041 tcacgacgag gccgactccg agccccagca gttcctcggc gaccgagggg accgaccgcc
    11101 ggtgcagctc gaccttgggg tcgtagcgga caccgctgtc gctgatgccc tgccagtccc
    11161 acgtgtacgg cgtgtcgcac cagcggcacg acaggttgca accgcccagc cgcaggaacc
    11221 cgcacctgcg gcccatggac cgtccctctc cctggacggc ctcaagtggg gccgaagatc
    11281 tcgttgacca cgagttccgg ttccacaggg caccacctcc tccttgtacg tgacgtacgt
    11341 cattgccgtg gccggggggc cggctccggg atcagggccg gtactccgcc caggtcttgg
    11401 gcgtctcgga gatgcggacg gagctgagct ccgggaagtc ggccttccac tgctcgaaca
    11461 tccagacggc gaggttctcc gcggtcgggt tcccctcgac gacgtcgttc aggtgccggt
    11521 ggtcgagggt gtcgtccagc cacttcttga acaccgagag ctcgccgtag tcccggacga
    11581 aaccggtggc ggtcaacgcc gaccgctcgg cactcagttc gagctccacc gcgtagttgt
    11641 ggccgtgcag ccgggcgcac tggtggctct cggggaggcc gcccagccgg tggctggcgg
    11701 agaagtcgaa tcgtttggtg atacgcaggg tcatgacggc cagggcctct cttgggggga
    11761 aacagggaca tcaaggggca gggggcgacc gacaggggtc acgcggggaa ggccgtggcc
    11821 tccaggtgca caccgagctt cgccagcacc gagtggcggg agacgacggg ctccagaccg
    11881 gcaccgccgc cgacgggcgg agacagcgga tcgatacggg tccccgggtc ggactcgtag
    11941 aagaacacca gggacagcag ctcctcgtcg ggggcgctcg ggctgggagc gagcacccgg
    12001 tggcgcagcg cccgccagcg tccgtcggtc cagcgctcca tcaggtcgcc caggttgacc
    12061 accagcgcgt ccggccggtg gggcggcgcg aaccagccgg ccgtctcgtt ccacgcctgg
    12121 aggccgccga cccccagctg ccggctgagg atcgtgaagg cgcccagatc ggtgtggggg
    12181 ccgttgcgca gctgcccgct cgccaccgtg cccaccgagg cgagcgaggg gtaccagctg
    12241 acgttctggg tccaggtcgc gcgggtggcc cggctggtga agaagtcccc ggggaggccg
    12301 agcacctggg cgaagagctc gttcagggcc tgcgccaccc gccgcatgtg atccgtgtac
    12361 gtctcgacgg cgcggcgcag cccggggagt tcaccgtccg gccagcggtt gggcgggtag
    12421 cagtaccggt cgagcgcctc gtcccccgac cggtaggagg ggccggagta gaaggactcg
    12481 tgcagatcgg ggggtgccgc cgcctccgcg ccctccgcac ggggcacgcc caccccaccg
    12541 cccggatgca tctccagcca gccgctctcg tacggggcgc cgatcgcgta cggccgcttg
    12601 gcctcgctcg gcagcgcgaa gaactccctc ccgcgcgctc gcagttcctg catggcggtc
    12661 tccggcacgc cgtgccccgt caggaggaac atgccggtgt cgcgtaaccc ccggtccagg
    12721 gccgcggcgg tctcctcccg ctccgcggcc gaggcggtcc gccagccgcc gagatcgacg
    12781 acgggaacag cgctgtccat gaggacgtcc tttcgtatgg tgcgaagggt caggcaccga
    12841 ggaccgcgtc gaccgccgac gcgaggatgt cgatgccctc tttcagctcg ctctcggtca
    12901 cggtgagcgg agggagcagt ttgacgacgg agctgtcggc gccggacgtc tcgaccagca
    12961 gcccccgcct gaacgccgcg gtcgacaccg cggcggcctc gccgccgctc ccgtccccgg
    13021 ccggcccggg gattccgagc cctgccgcga gacctcgtcc ggtgacgtgg agccccgcgc
    13081 cctcgtacct gtccgcgatc tcgccgaggc ccgcggccag acactccccg gagcggcgca
    13141 cggccttctc caggtcgttg cccgaccagt aggcccgcag cgccgcggcc ccggtcacga
    13201 aggccgggcc cacgccgcgg aaggtgccgt tgtgctcacc cggctgccag acgtcgagct
    13261 cgggccggat gagcgtgagg gccagcggca gaccgtatcc gccgatcgac ttcgacaggc
    13321 acaccatgtc gggagtgatc ccggcgtcct cgaagctgaa gaacggcccg gtgcgtccgc
    13381 atcccatctg gacgtcgtcc acgacgagca ggacctcgtg ccggcggcac acctccgcga
    13441 gggtgcgcag ccacggcgcc gaggccgccc gcaccccgcc ctcgccctgc accgtctcca
    13501 cgatcacggc ggccggcctg tccagcccgc ttcccgggtc gccgatcagc cggtccaaca
    13561 gctcggggga gccgtccgcg tagccgtcgt acggcaacgc gacgccgtgc gtcaggggga
    13621 tgccggccgc ggcccgcttg gccgcgttgc cgctcacggc cagggcgccg agcgtcatgc
    13681 cgtggaagga gttggtgaag tggaccacgg tggagcgacc ggtcacgcgg cgggccagtt
    13741 tcagcgccgc ttccactgcg ttggccccgc ccggaccggg gaagaccacc cggtagtcca
    13801 ggttccgggg agcgaggacc gtctcctgga gcgccttcag gaagtggcgc ctggcgacgg
    13861 tgaacatgtc cagtgagtgg gcgacgccgt cacggctcag gtagtccatc agcgcgcgct
    13921 tgagcacggg cgggttgtgc ccgtagttca gcgccccggc accggtgaag aagtccagat
    13981 agcggttgcc gtcctcgtcg tacagccagc ttccccgggc ccggtcgaac accacgggcc
    14041 aggcgcggct gtagctccgg acctcggatt ccagctcctc gaagacgtcc acctcacgcc
    14101 ccctctacgg tgaccgccga cgcggcgtag acggtggggt cgtggatccc ggcggcttcg
    14161 aaggccccgc gccgctccac gcacgaggcg cagcgcccgc agtgcagctc ctcgccgcgg
    14221 aagcaggtcc aggtgtccgc gaacggcacg gagagccggt ggccgagagc gatcacctcg
    14281 cgcttgagca tgcttgccag gggcgctatc aggtccaggt cggggtgggc gtggccccgg
    14341 gtgccgatcc gctccatggc gaggaaggcg tccaggaact ccagggaggt gtccgagggc
    14401 ccgacgtcct cggccatgat gccgaaggcc acggcctccg cccgctccac gacggcgagc
    14461 gcgaaggcgg ccgacagcag gagggcgttg cggttaggaa cgatgttggg gcgccccggc
    14521 accgcggccg caccgctgct cccggcgccc tccacgggga cgtccagtgc cggatcggtg
    14581 agtgacgacc cgcgcagcac cccgcgcgcc ccaccgaggt cggcctcctc gtacggtgcg
    14641 ccgagacgct cggccgccag cctggcacag gccagttcgc gccggtggcg ctggccgtag
    14701 tcgatgccca gcaggtgcag ctcgtggccc tgggcacgga ggtggtaggc catggtgacg
    14761 gagtcgattc cgccggacac caccgcaatg atcttcgaca cgcgtcgtcc tcacttcgtc
    14821 gggtaccggg atgggggcgg ccgctcgggg acggccgagt gccgcgcggg cgtgtcaccc
    14881 ctgagcgggc cgccgggcgc agagcacgaa ccagtgccgg gccaggtgga tgccctctgg
    14941 cgtggtggcc tgggccgcgt agcgctcgaa ggagcggcgg tcggtggccg agtcgtagtc
    15001 ctcgaagatc ggcaccatct ggaggaaccg gtccaggtcg gcgggggtgt ggaagaactc
    15061 gtcgtaggag aactcgcgtt cctcctccac ggtgagaccg gcgtcctcca accgccggcg
    15121 ctcctgccgg accaccggct cgccggacca ccgcccgtac agctgccccc ggccgaagac
    15181 ctccttcagc gactggacgt cccgctcccc gatgcccagg tacaccaccg tgcccccggg
    15241 ccgcagcacg cggtggaact cctggggaag agcggcccgc ggcgcgaggt caccacgtcg
    15301 aacgtctggt ccgggaagcc ggtggccgag gcgtcgccca cggtgaaggc gacatggtcg
    15361 agccctgacc cggcccggtg gcgctcggcc gacgcgagca tctccgccga caggtcgatc
    15421 gcttcgaccc gtccgaacgc gggggcgacg gccagcacgt tgcggccgtc ggcgcatccc
    15481 acgtccagca gccgagccgt cggtgaaccg tgctcgcgca ccagggagtc gaagtgctcc
    15541 tcggggtcac cctgcggaaa ggaggtggtg cgctgtgccc cgctggaata gccgccgaac
    15601 ttctcggcga ccttggagta gaactcctgc cgctgggtca tggactgccc ttcgctcgaa
    15661 ggccggggtc tggctcggag ggcccatgct tccctcgcgg cggcaccgcg cagaaggaac
    15721 cacggtgccg ccctgagcgc acgtgcggtg cgcgagcgga caccccctgt gcccgaaggg
    15781 accgtgccga cggacgcccc gcaccgctcc cggcagcacg gggcggaccc tttggtgcgg
    15841 ccacgacggg ccggggcggg gaggtcgggc atggggcggg ggccgggcgg atgaggcacg
    15901 tacgggagag ggggcccggg gccggtgaaa cgcggatagg ccccgatccg tggatcgggg
    15961 cctatcggag gtggctgggg ccgggatcga accggcgacc tatcgctttt caggcgatcg
    16021 ctcgtaccaa ctgagctacc cagccacgca gccgctgggg ctgcaagcgg tcctgacggg
    16081 atttgaaccc gcggcctcca ccttgacagg gtggcgagca ctccaaactg ctccacagga
    16141 ccaagcaatg tgcgaaacaa gtctcgcaca cggtgaaacg tgcccccaac gggattcgaa
    16201 cccgtgctac cgccttgaaa gggcggcgtc ctgggccact agacgatgag ggctattggc
    16261 ccgcctgttc gctttgcagc gcgtcgggga cgtgagaagc atatgggatg ggtggagcta
    16321 tcgccaaaac ggtttacggc gagggcgtgg gccgggtcgc ggagcccgtc ggggacgggc
    16381 tgggggaggg cgaggcgggg ctctccccct tcaggttctc ctccggcaga tggcggctga
    16441 cctcggcggt cgtcagcccg agaccgccga gcgtgatctc gtcccaggcc tggagccggc
    16501 gggtctcgcg gtccaggtag agcaccgagg cacgtacctt ctcgggcttg tcgttctgca
    16561 ccgcgcgcag cccgccgccg cccgtggagc cctcgacctt gagccgcgta ccgcccttga
    16621 gctgttcgtt gacccggtgg tggacatggc cggccagcac cagcgggacc gtgccgtcgg
    16681 tctgccgggc ggtgttcggg tcgtgggcga ccgcgatgtc gaccggggtg ccggcctgct
    16741 cctggtcgcg gagggcggac gccaggcgca tgccctgcag ctccgcggcc gccttgccgc
    16801 cgaccggctt ggtgcggtcg ggggtgaacg aggcgtcgcc ggtgccggcg atccgcagcc
    16861 cggccacgtc gacggtccgg ccgttgtcca ggacgcgcac gttccggacc ttctccaggt
    16921 acgcctgcgt gaccttggag tcgtggttgc cgcgcaccca gacgtagggg gcgccgaggt
    16981 cgcggatcgg gtcgaggaaa ccgttctccg cggccgagcc gtggtccatc gtgtcgccgg
    17041 agtcgatgat cacgtcgatc tcgtactgct tcacgagcga ggcgatgatg tgccaggccg
    17101 ccgggttgag atggatgtcg gagacgtgca gggcgcggat ggtgccgggg tccggctggt
    17161 agacggggag cgttgaggtg gcgtcgtaca gccgggtgac gttggtgacc aggcgggcca
    17221 gctcctgctg gtagatgtcg aactcggtga cgatcgaccg ggcgtcgccg acgagcgacg
    17281 gggcgctgga gagcagcccg gagaacttgg gctccaggac ggacttcggg ttccaggtgg
    17341 cgtacgcgct gacgcccgac gcggccagca gggtcagggc gagcccgccg gcggccaggg
    17401 cgcggcgggg gcggcggtag acgacgaggc cgagcgcggt cgccccggag atcacggcga
    17461 cacaggagcg tacggccagc tcgcgggtgc cggcggcgac gtcccgggtg acctcgtcct
    17521 ggagtccgga gaaccgttcc ggctggtcca ccagggcctg cgagcgcacg gggtcgaggc
    17581 ggtccacgtt cacgtcgagg cggagcgggg cgatgtgcga gtccagctcc agggcgccca
    17641 gcggggacac gttgatcttg ctgccgccgg tgagggacgg gcgcagggtc atgttggtgt
    17701 ccatggggcc gaccggcgta cggatggacc ccacggcgag cagcccgagc caggccccga
    17761 tcacgacgac ggcgagcatg gcgagggcgc gtacgaacgg cctgggggtg gcggtgccca
    17821 tgaggtcgcc ggtggcgggc ctgcgtgccg ggcgtttcgg ggacttcgcg gagtcgggcc
    17881 ggacgagctg ggtgaggcgg tgccggacgc ggtcggcagc ggcacggaac ggagcgcgga
    17941 ccattgggcg cgtatgcccc ggtacggctc cgcccatgcc ggggtgccga cggcggagtg
    18001 gatcaggcga ggggcggcga ggggcatggg gtggccgtga agtggatcag gtgcggtggc
    18061 catctgcccg tggcgggccc ccgtacgtga caatggcggg gtgctggaga tgacgcggga
    18121 gcagttcgaa gagctggtga gccaggctct tgaccggatt ccgccggagc tgatgcggct
    18181 gatggacaac gtggcggtct tcgtcgagga cgaaccggag cccggcgacc ccgagctgct
    18241 cgggctctac gagggcacgc cgctcaccga ccgcggggag tggtacgccg gggtgctgcc
    18301 ggaccggatc accatctacc gcggtccgac gctgcggatg tgcgagacgc acgaggacat
    18361 cgtggccgag accgagatca ccgtggtcca cgagatcgcc caccacttcg gcatcgacga
    18421 cgagcgcctg cacgccctgg gctacgggtg agcgagcagg caccggacga actgccggaa
    18481 ccgggaccac cttccgcttc gcagccacgg gtgctgggcg cggtcgcggc gggcggcgcg
    18541 ctgggcgccc tcgcgcggta cgcggcgctg gtgcggtggc ccgccgccga gggcggcttc
    18601 ccgtggacgg tgttcgtcgt caacgtgacc ggctgcgccc tgatcggcgt cctgatggtg
    18661 gtgaccgtgg agcgcggccg ggtgacgcac ccgctgctcc ggctcttcct cggcgtcggc
    18721 gtactcggcg ggttcacgac cttctcgacg tacgcggccg atgtctcggg cctgctggtg
    18781 cgtcaggaac tcccgacggc ggtggcgtac atggcgacga cggtcgtggc ggcgctggcg
    18841 gccgtgtggg cgggtgcggt ggtgacacgg cggctgctgg accggggcgc acggggtggg
    18901 cgcggcgggg agcgggccgc gtgaactggt tcctggtggt catcggcggg gcggtgggcg
    18961 cgcccctgcg ctatctgacg gaccgggcgg tccaggcgaa ccagggccgg ggtgtcgcgt
    19021 acgtcttccc gtggggcacg ttcacggcca acgcggcggg cagcctgatt ctcggggtgc
    19081 tgacgggggc agcggtctcc tcgtccgcgt ccgccctgct ggcgacgggg ctgtgcgggg
    19141 cgctgacgac gtactcgacg ttctcgtacg aaaccctccg tctggccgaa acgggccggt
    19201 ccttcctcgc tgtggccaac gtggtggcgt cgctgctgat ggggctcggg gcggtgttcc
    19261 tgggggcgga actggcgggc gggttcgggg ggtagggggt cggcccggcc cggggcttcg
    19321 gtcggccccg acgggccccg cgaggcggtc cggcgcgccc tccaccccgg ggctgcccgg
    19381 cccgtcggtg gttcgggcgt gtctccggcg gggtccgggg agttgggcac ggcaccacac
    19441 catcgcgtac ggcgcgcttt atgccgcacg cgacagccca ccccgctccc cgcccccgct
    19501 ctgccccgcc ccggaggtgc cacccgtgcg caagttgtcc gcccctgtcc gctgggcagc
    19561 cgtcaccgcg ctgacgatcg ccgcgtccac cggctgtatg agcgtcggtg acgacggcgc
    19621 gaggcccagc ccctccggtt cctccgactc gaagggccgg accgccgacc cggacgacga
    19681 gacgacggcc ggatccggcg aagccggaca ccgtgggggt gacgcccaca cccactccga
    19741 cggcgactcc gccgaccgca agaaccccaa ggggaagccg agtccggagg cgtccgggag
    19801 cgccgtgccg tcggacacac cgaagggcgc gcgcccccag cccggtgtcc cccacccccc
    19861 gcgccccggt caaccggcgg cccccacacc ttccacgccc ggccccgggg agccaccgcc
    19921 ggtcgtgccg gaaccgcccg ccccgcagcc gtcccccgac ccggacccgg accccgaacc
    19981 ggagcccacc gaaccctccg aaccgccccc ttccgcgtcg ccggccgcgc agctgcggac
    20041 acagtcgatg gggggcacgg gggagggcag gccgttgcgg acaccggagg catcaccgca
    20101 ggtcaggccg gtgtagccgg agcgggaaga gggccgggtt gcgcaatgtg ggtgagagtg
    20161 cgtatggtgg tagatcgttt gatcccattg cccggcgccg acacagaaga gcgccgtgtg
    20221 gcgcgtactc tcccttgccg tggctggacc gcattgaggc ggtcgaaatt gcgaatcacg
    20281 gagttacggg cgcgtgccga gactccggaa ggtttcgcat ttcgcatgtc aatttccagt
    20341 tctgaccaca ccgtcatgcc cgagaacatc gacaacgccg agctcgccga gctcgtcgag
    20401 gccgctgtga ccgaggcccc tgccggcgcc accgccgcag ccgggaaggc tccggtggct
    20461 gagaaggcgg ccgagaagtc cgtcgccgac ttcatcaccg aggacaagcc ggccgccaag
    20521 gccgaggccc ccgccaagac cgaggccgct gccgaggccg agacggacga ggcccccgtg
    20581 gcggagaccg acgccgagcc gaccatcacc ttcggcgacc tgggcctgcc cgacggcatc
    20641 gtccgcaagc tcgcgcagaa cggtgtgacc gcccccttcc cgatccaggc ggcgaccatc
    20701 ccggacgccc tggccggcaa ggacatcctc ggccgtggcc gtacgggctc cggcaagacg
    20761 ctctccttcg gcctgccgct gctggcctcg ctctccggtg gcgccaccga gaagaagaag
    20821 ccgcgcggca tcatcctcac cccgacccgt gagctcgcga tgcaggtcgc ggacgccctc
    20881 cagccgtacg gcgacgtgct cggcctcaag atgaaggtcg tctgcggcgg tacgtcgatg
    20941 ggcaaccaga tctacgcgct ggagcgcggt gtcgacgtcc tcgtcgccac cccgggccga
    21001 ctgcgcgaca tcatcaaccg tggcgcgtgc tcgctggaga acgtccaggt cgccgtcctc
    21061 gacgaggccg accagatgtc cgacctgggc ttcctgcccg aggtcaccga gctgctggac
    21121 cagatccccg gtgggggtca gcggatgctc ttctccgcca ccatggagaa cgagatcggc
    21181 acgctggtca agcgctacct ctccaacccg gtgacgcacg aggtcgacag cgcccagggc
    21241 aacgtcacga ccatgtcgca ccacgtcctc gtcgtgaagc cgaaggacaa ggcgccggtc
    21301 acctccgcca tcgccgcccg caagggccgc acgatcatct tcgtccgcac ccagctgggc
    21361 gccgaccgca tcgccgagca gctcatcgag tccggtgtga aggccgacgc gctgcacggc
    21421 ggcatgaccc agggcgcccg tacgcgggtc ctggaggact tcaagaaggg ttacgtcaac
    21481 gcgctcgtcg cgaccgacgt ggccgcccgc ggtatccacg tggacggcat cgacctggtc
    21541 ctgaacgtgg acccggccgg agaccacaag gactacctgc accgctcggg ccgtaccgcc
    21601 cgggccggca agtccggtgt cgtcgtctcg ctggcgctcc cgcaccagcg ccgccagatc
    21661 ttccgcctga tggaggacgc gggcgtcgac gcctcgcgcc acatcgtcca gggcgcgggc
    21721 gtcttcgagc cggaggtcgc cgagatcacc ggcgcccgtt cgctcaccga ggtccaggcc
    21781 gactccgcga acaacgccgc caagcaggcc gagcgcgagg ccgccgacct gacgaagcag
    21841 ctggagcgcg tccagcgccg cgccgtggag ctgcgcgagg aggccgaccg cctggtcgcc
    21901 cgtgccgcgc gcgagcgggg cgacgacccg gaggcagcgg tggccgaggt caccgccgag
    21961 gcggaggccg ccctggtggc cgccatctcc gtccccgagc agccggccgc ccgcgaggag
    22021 cagcgccgcg acgagcgggg caactacgag cgccgcgaca accgcggtgg cgaccgtggc
    22081 ggctaccggg gcggcaacga ccgtcgtgac gaccgcccgt cgggtggctt ccgctccggt
    22141 ggtgaccgtc gtgatgaccg tggtggccgt ccgttcgagc gtcgtgacaa cgaccgcccg
    22201 tccttcaacc gtgaccgtcg tgacgaccgc ccctcgggtg gcttccgctc cggtggtgac
    22261 cgtcgggatg accgtggtgg ccgtccgttc gagcgtcgtg acaacgaccg cccgtccttc
    22321 aaccgtgacc gtcgtgacga ccgcccctcg ggtggcttcc gctccggtgg tgaccgtcgt
    22381 gatgaccgtg gtggccgtcc gttcgagcgt cgtgacaacg accgcccgtc cttcaaccgc
    22441 gaccgtcgtg acgaccgccc ctccggcggc ttccgctccg gtggcagcga ccgcccgttc
    22501 aaccgtgacc gtcgtgacga ccgcccctcg ggtggcttcc gttccggtgg cagcgaccgc
    22561 ccgaccggcc gtcgtgacga ccaccgcggc gccaacaccg gtaccaacac cggcaccttc
    22621 ggccgccgcg acgacaagcc gcgctggaag cgcaacggct gaccccaccc cggccgactc
    22681 ccggccggtg aggtccgcct gacagaccgg cagggcccgt acgccaccga accgactcgg
    22741 tgacgtacgg gccctgttgc tgttccctca ctgctcccct cgccgctctc caggggcgcg
    22801 aaccggcgtg aaagggacgc gacgggggcg cggtcggggc gtgacggggc ccgacaccga
    22861 taccggatcg gctgctggga tcgggcgggc tatgctcgtg ggtgatgttg cacgggccgt
    22921 tagctcaatt ggtcagagca gcggactttt aatccgttgg ttgtgggttc gagtcccaca
    22981 cggcctacca ctggaccccg ggccagagtg tttctctggt ctggggtcgc tgcatgttcg
    23041 ggtgcgttcc gggcgctcgc tccacgcctc gggcccggtg cggccacgga cgccaggctc
    23101 tcgtcggacg gaccgccccg cagctcggcg tacctggcgg tgtgcggcag ccgcgcgcca
    23161 cccctcatcg acgatgcgcg agggggccgg gcagtggtcg gagtggccgc tccgatggcg
    23221 tagagtggtg tttaccgacg cggggtggag cagctcggta gctcgctggg ctcataaccc
    23281 agaggtcgca ggttcaaatc ctgtccccgc tactgaagat ccaggcccgg tacgcagacc
    23341 gcgtaccggg cctgagtcgt tccccggtgt ttccgggttg accttgacgc agcgtaaaga
    23401 tctagcgttt ccggcatgga gtggtccatc caggaaatcg ccaggaaggc cggcaccacg
    23461 agccgcacgc tccggcacta cggggagctc ggtctcctcg tgccgagccg ggtcgggagc
    23521 aacggctacc gctactacga ccaggacgcc ctcgtccggc tgcagcggat tctgctgctg
    23581 cgggagctgg ggctgtccct gcccgccatc aagggggtgc tcgaagggca gcgggacacg
    23641 gccgtggcgc tgcgggcgca tctgcggctg ctcgaacagg agcaggcgcg catcgggcgg
    23701 cggatcgcct cggtgcggac cactctccac aggacgcagg aggggatgga actcatggcc
    23761 gaggaagtgt tcgacgggtt cgaccacacc gctcatgagc gggaggtgac cgagcggtgg
    23821 gggcgtgagg cgtacgagga gggcgaccgc tggtggcgtt cgctcgggga gagggggaag
    23881 cgggcgttcc gggacgagca cgaagccatc gcgcgggact ggggggcggc caaggaggcc
    23941 ggggtgggtg ccggcagtga cgtggcacag gagatcgccc ggcggcactg tgcgtggctg
    24001 tccacgacgg tcgctcccag ccggtcgtac gtcatcgggc tcggcgagat gtatgtcgcc
    24061 gatccgcgct tcggaaagaa ctacgatcga tacggggacg gcaccgccgc cttcgtacgg
    24121 gatgcactga cgatctacgc gggacaacgg ctctccggct gaccacgggg agcgcagggg
    24181 ttcccggccg ctttccccct atttggccga cgacgagtcg ccgcacggcg cggctccggg
    24241 aagcctggac ggggcgcggt accgtccgca gccgtggccg gaccgggcag gagtgcacag
    24301 gtggggatgg cggagaaggg gcgtggacgc gtgacgggga gcttcggcct cccggggcgc
    24361 gggctgtccg gctccgggcg ggtgaagacc ggttccgggc agggtaaggc cggctccgcg
    24421 gggcggggga agccggtggt ggcccggagc gtcgggaccc ggcggttcgt ccggctgctg
    24481 ccggtgctgc tgatctgcgg cgggctcctc ttcgactcga tcgccccgcc caacttcacc
    24541 gccgtcccca tcttcgtggc cgcgccgctg atcgccgccc ccttcttctc gctcgccagc
    24601 accatccgta cgggcgtggc cgcggtcctc tccgtcatcg cgatgcggct ctccgacggg
    24661 acgtccaccc aggtcgtccc ggtcatcgag atgatcacgg tcctcaccgc cgccgccctg
    24721 gccctcgtca tcaacggggt cgtgcgccgc agcaacgagc agctggcctc ggcgcgggtc
    24781 atcgcggaga cggccatgcg g
//
