LOCUS       NZ_CP032543            27578 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3578538
            Orig. end                         :: 3606116
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27578
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="16"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..27578
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27578
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17578](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17578
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    complement(274..286)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            complement(1026..4327)
                     /locus_tag="D6270_RS33660"
                     /pseudo=""
     CDS             complement(1026..4327)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967606.1"
                     /locus_tag="D6270_RS33660"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRFGVLGPLAVWDGEGREVRVPEAKVRALLADLLANDGGPVSADR
                     LIHDLWGDAPPGRPAGALQAKVSQLRRAIGRDRVVRQPPGYRLRFDDGDEVDAVRFRAL
                     VAQARPVQDPRARAALLTEALELWRGPAYADFADGPFVRAAAQRLAEQRLSVLEEQARA
                     RLEAGDHTLLAGELADLVALHPLRERLRAVQMRALYAAGRQSEALASYEDLRTRLAEEL
                     GVDPSPELAALHGAVLRQEPGLSAAPPTEAVARATGTPPPGPTAPATAIPPPHSNLPAP
                     LPPSWAVAKPSPTCPDSSQRQGW"
     misc_feature    complement(3482..3484)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4495..5259
                     /locus_tag="D6270_RS33665"
     CDS             4495..5259
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609629.1"
                     /locus_tag="D6270_RS33665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_264081512.1"
                     /transl_table=11
                     /translation="MTKYARRKALVVGEATDIGLAIAKRLVEGGASVLLTARTEAERAH
                     AVAELGSAARVVSPSAVEAALTGAPGPAGADTNDSTGLGDGPTGLGDGPTGTTRLGDGS
                     TAPTGLVHDPTGAAGAIDPTGLTSTTSPTGTTGTSPTGPTTVGLLFADAIPTARPLLPY
                     VEDGGAVVLTAPTPCPDAVRALADELAARGIRVNAVAPGCIEAPGSGAVPLPPLGRLGA
                     AEEVARAALFLATEATFTTGARLPVDGGLGHP"
     gene            5315..6610
                     /locus_tag="D6270_RS15935"
     CDS             5315..6610
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609630.1"
                     /locus_tag="D6270_RS15935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_109164811.1"
                     /transl_table=11
                     /translation="MSTAPDTAPAAAAAPDPKGGGEDQQKLPLFALLALATAVFITCLT
                     ETLPAGLLPAMSEDLRVSQSATGQTVTVYAIGTALTAIPLTAATAGWQRKKLLLTAMAG
                     FALANTVTALSSVYELTMVARFVAGVAAGLAWALLAGYARRLAPAHLQGKAMAIAMAGI
                     PVALSLGVPAGTFLGEWLGWRVAFLSMTVLTVVLLVWIFVGVPDFPGQGRGERPKLLRT
                     LTIPGVTPVLFVTLVFVLAHTILYAYIATYLKDLGLGSSTGLVLLVFGAASLASIWIVG
                     AQINRRLRGLTVGGALLVAVAALLLAVLSDTTALVYVAAVLWGLGWGGVPTLLQTAVGD
                     AGGESADAAQAMLVTLWNVAMAGGGIVGGILLDTVGSESFPWTVLLLLLPVIAVVLYAR
                     QAGFPAHRPVAEAEEASAPAGVPAPTGGDPAA"
     misc_feature    6628..6645
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.94"
                     /tool="antismash"
     misc_feature    6631..6646
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            6886..8886
                     /locus_tag="D6270_RS33110"
     CDS             6886..8886
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024935.3"
                     /locus_tag="D6270_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_225976872.1"
                     /transl_table=11
                     /translation="MSSSEVRAGVPGDGAYMQTFMDEIFRAFQRPEQRRWAQAYLWALI
                     HVSGKKTPRRMALAKPLPPAAAHGLHQFINASPWEWTPVRRRLARRVAARTTPHAWTVA
                     ELIIPKRGEHSVGVHRRLDPVTGRTVNCQRALVFFLVSGTQCYPVDWSLVLGGAWDSDR
                     ERRRRARIPGSEAGRTPADHVVGYAAEAAAQPQLAGLPWVLDLTRCDDAAGVLAGLTRQ
                     RADVVCEVAPHHLVLLTGQHTPAVTTVSALMEVRHARQTHVLLRQTPDGRVRPVPVHTY
                     AGTVGAPRPGFGDDVGARPYRILERPDPDGRQPARYWLTTLTDRRVEDVLRLARGHAAA
                     LSAVTTLGRRFGVLDFEGRSFPGWHHHMTMASAAYVYQRLPGASGGGPGGAAAPPQAPP
                     RRRNPPAPPPPSHSPVPPTDMAAPRIDVKPKRRGGWGSMRQVLVVEQDAAAAAAMVSDL
                     RRQGFAARSVSTGERALRVYGDADLVLFSLELPDIDGLELCRSLRGGGDTALIAVTDAD
                     AELERVLVLHAGADDCVVRSWGFREVGARIEAVLRRARPRQNLPGTISLRDLHIDPRRR
                     EVRLGGRLVGVTSKEFELLYTLAATPETVVTRKELMARVWGSNWGHTSRTIDTHVSSLR
                     AKLGSGGWIITVRGVGYRMGYAWQMPETTAG"
     gene            complement(9015..9773)
                     /locus_tag="D6270_RS15950"
     CDS             complement(9015..9773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609633.1"
                     /locus_tag="D6270_RS15950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arylmalonate decarboxylase"
                     /protein_id="WP_109167416.1"
                     /transl_table=11
                     /translation="MDLFSLPRLGVVVPPENPTAEPEFNHLLGAGMNVYTSRFPVTPGA
                     ELRAMLETYNEVLPGLLGSFGALRLDATVVACSASHYLLEPAGDRAFCDELSERTGSPV
                     QSSTQAILAACEALGVSRLTLVSPYEPWLTDTSRAFWEGAGLTVDGVVLVPAEEAARPG
                     GDARFDPYTVTTGTILRRIRERELPAGTALLFTGTGMGTLAALTELARREPHRTLLTSN
                     LASAWWARRAVGATGEAHHPLLRRLEGARV"
     gene            10001..11155
                     /locus_tag="D6270_RS15955"
     CDS             10001..11155
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967613.1"
                     /locus_tag="D6270_RS15955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isopropylmalate synthase"
                     /protein_id="WP_109164808.1"
                     /sec_met_domain="HMGL-like (E-value: 4.5e-49, bitscore:
                     165.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAEDPEKLERPPRISDATLRDSAHMAGVEFGPADAAAIADLLVR
                     TGVELVEVGMVSGPDSKDADLVLATHEAVTPERSMTLVVVRDRRQVARALDEAERLGVR
                     HIMYSIPTSEQHAQLKLDSASPKFLQALARSAIQQAKDRGFHVTFSGEDGARTPRGRLV
                     PYVEAGFAAGADRFRLAETVAYLSPWQMEEVIADITAIDGSEIEIHSHNMLGMAVANSL
                     AAVRAGAQWISATVGGIGERGGNAPLAELLTSLRVIHGDTRFDLTHLTELSRIALRGAG
                     LGEAFQSGPTTPHAFAYELPGQLSHPHAYETLPAELVGNSRELRVRTRLTTALVRWALA
                     DSGLEVDVDAFTPWLAERQERDGRPLLDRDTIRKAAIDFRPVPA"
     gene            11194..11379
                     /locus_tag="D6270_RS15960"
     CDS             11194..11379
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967615.1"
                     /locus_tag="D6270_RS15960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysine biosynthesis protein LysW"
                     /protein_id="WP_093689889.1"
                     /transl_table=11
                     /translation="MSTATLTGVCPECETDLTVPPVALGETLSCPECILTLRVEAVEDG
                     RLTLEMVEVQLRDWGQ"
     gene            11381..12235
                     /locus_tag="D6270_RS15965"
     CDS             11381..12235
                     /GO_function="GO:0016881 - acid-amino acid ligase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967616.1"
                     /locus_tag="D6270_RS15965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_109164807.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 7.7e-09, bitscore:
                     34.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 9.5e-21, bitscore: 72.8,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 5.7e-06, bitscore:
                     24.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAALRPVALVADRIAWEERLLIEAAPAFGLRIDWVNDESLSLGHP
                     DAPSVKGYDTLLIRSRSYTRGGLIATLAEAAGVPTLNTARAIHACENKAVLRALLRTAG
                     VPVPDHRLVLSRKDFDKALADLPLPLVLKPVFGGMGKRVTLIRHADTAHSVYDYIEDLA
                     HAFEQASVVEPYLGGSSVRCLVVGRELIGAAEFESGGSDWRNNAALGNKNRAIAHDPDV
                     VKIVDGVVDVLGPGIYGVDLFATPDGHVVNEVNHAPGFRAVASATGADIPSAIARHVQE
                     LLA"
     gene            12232..13287
                     /gene="argC"
                     /locus_tag="D6270_RS15970"
     CDS             12232..13287
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379927.1"
                     /locus_tag="D6270_RS15970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_109164806.1"
                     /transl_table=11
                     /translation="MIRAGVVGASGLAGGELIRLITQHPDLELTFLGGSSNIGRRPSEL
                     HPGLRDDRGLTIQPVTEEVAEKVDVLFLATPAPVSAELSSLLADRIPAVVDLSGAFRIR
                     TPELHDRWYPKVRRRTDLADRFVYGVPELIGDQLKDAALISLPGCYATAITLGLAPLTL
                     GLGLGLKTVVVDGKSGSSGGGVQLRTSDLHPFRAGAIAPYSPTGHRHAAEVGDFLERSK
                     PGTIGNLSMSAYGVPNVRGLLTSSYVFTDEKVDQRELNRDYLRFYKGRRFVRVRRHNET
                     LIPVPDPQVVLGSNYADVTVLLDEEGGRIVVLAALDNLVKGAAGQAVQVTNLRFGLPEE
                     TGLTQQPVMPA"
     gene            13284..14105
                     /locus_tag="D6270_RS15975"
     CDS             13284..14105
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609638.1"
                     /locus_tag="D6270_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetylglutamate kinase"
                     /protein_id="WP_109164805.1"
                     /transl_table=11
                     /translation="MSASSPLRTVPTVVKLGGSCLDDLDGTWWDDLARHGQDRPLVLVH
                     GWSKPLRRLDARYREPSAILRDRYGNQSRWTTPEVIDDIKAVSAVLAEDVLARLESRGI
                     TAERLLGSDGLVSAAEGERWWWREKRLVELENLVGPITGVDPAPLKNLQPGHAYLVTPL
                     ARNAAGQEVNTDADRAAAAIAGATGASDLVLVTDVGHLLIDDRPVRRISAADAAAFRDQ
                     GAKGGMRKKLRAAGEALEGGVERVVIGSAAVTELLDGSTGTLITRSEGGEA"
     gene            14102..14665
                     /locus_tag="D6270_RS15980"
     CDS             14102..14665
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609639.1"
                     /locus_tag="D6270_RS15980"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26.; Members of
                     this family of hydrolases with an active site Cys residue
                     belong to MEROPS family C26; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="WP_109164804.1"
                     /transl_table=11
                     /translation="MTRSRVLVVNNGTLSLRQLRARFEELGSDTEAVDASSVPARVGGR
                     YQAIVLSGTKVRAYDSAFYKPLIDLVTTADVPVFGICGGMQILAVAAGGRLAEGPQRVG
                     GYEVRVDTEEPLFTYVKPTVTVFHRHTLYLQEAPAGYRSIGRSEHAPVEFLRSDDGRIH
                     GAQAHLEFRTDGLEILRGFARLYQ"
     gene            14709..15845
                     /locus_tag="D6270_RS15985"
     CDS             14709..15845
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967620.1"
                     /locus_tag="D6270_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Glu/Leu/Phe/Val dehydrogenase dimerization
                     domain-containing protein"
                     /protein_id="WP_109164803.1"
                     /transl_table=11
                     /translation="MSAAVPEEPQDPALTVHLNGSGGAIKGWVVIDTLVDGLAMGGTRM
                     TTGVSEEEVAGLARDMTEKFTLAGLRIGGAKAGIVADGTNSGGAAREETFRTFGRTVKP
                     LLHGGIHLGIDMGVTPADRAVFFEEAEYDPRYRLGAPDMPIDWRTYYEPLIDATGHGVG
                     VAAITALEASGRTEPARVVVQGFGAVGRAVARFLEDRGHIVVGIADIQGTISADRLPVA
                     ELVAVTDQFGAIDRARLPQDVKLSGEPDAWLDVDADILILAAQKYAINAENAHRLRAGL
                     VVEGANLASSAAAKEKVAASGAGLVPGVIANIGGAASAALAVTRVVPFDLAAEARKAWV
                     FDWVGDRVRRNTRDLLEIAASRAGDPLPELLAARRKER"
     gene            15845..17578
                     /locus_tag="D6270_RS15990"
     CDS             15845..17578
                     /NRPS_PKS="Domain: AMP-binding (46-470). E-value: 2.1e-83.
                     Score: 272.1. Matches aSDomain:
                     nrpspksdomains_D6270_RS15990_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379930.1"
                     /locus_tag="D6270_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_109164802.1"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-80, bitscore:
                     268.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAARERPAPVAGAGAQGRAGTDVERAEAYRRRGWWRDETFLDD
                     LHRQAREHPRRLAIAGRRVAESRTDTLDYAELDRLTNRFALALLELGLRRGDFVAVQLP
                     NRWEMVPLIFASIRVGAVIIPISPICTEEELRHRLGLTEARVCVTLPEWSGTPLAETAT
                     RLKAELPSLKHVLVVDGPPPEGALPFHEHFVAQEREEREGAAARLDGLALGADDPFVVL
                     FTSGTTGLSKGVLHSQNTVHSAVRGYVDAFGAGDGEGQEWVAAVSTPLVHYSGFAQGVL
                     AGVMLGGTVAFQDVRRNEALLDLVERYGATLLYGPPATLADVAASQRAERRDTSTLRHV
                     VIGSAPVLQELADEVHETLGARAHSLWGMSENGPVTTTRPEDPEGWSARSNGRAIDAME
                     TRIEASGAYGGSAGPVGRLKVRGASLALGYHRRPEAFAAELDEDGWFDTGDLARDDGQG
                     GIRIIGRARDAVLRDGRVAPMTELEAVIGSHPRAEEAALVGLETAGGEGPGNVIVAVVV
                     PRGGPGPTLEEVRARVTDAGHDARFLPDRLELVPALPKTLTGKVRKAELRERYATSPSA
                     P"
     aSDomain        15983..17254
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS15990_AMP-binding.1"
                     /evalue="2.10E-83"
                     /label="D6270_RS15990_AMP-binding.1"
                     /locus_tag="D6270_RS15990"
                     /protein_end="470"
                     /protein_start="46"
                     /score="272.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HRQAREHPRRLAIAGRRVAESRTDTLDYAELDRLTNRFALALLEL
                     GLRRGDFVAVQLPNRWEMVPLIFASIRVGAVIIPISPICTEEELRHRLGLTEARVCVTL
                     PEWSGTPLAETATRLKAELPSLKHVLVVDGPPPEGALPFHEHFVAQEREEREGAAARLD
                     GLALGADDPFVVLFTSGTTGLSKGVLHSQNTVHSAVRGYVDAFGAGDGEGQEWVAAVST
                     PLVHYSGFAQGVLAGVMLGGTVAFQDVRRNEALLDLVERYGATLLYGPPATLADVAASQ
                     RAERRDTSTLRHVVIGSAPVLQELADEVHETLGARAHSLWGMSENGPVTTTRPEDPEGW
                     SARSNGRAIDAMETRIEASGAYGGSAGPVGRLKVRGASLALGYHRRPEAFAAELDEDGW
                     FDTGDLARDDGQGGIRIIGRARDAV"
     CDS_motif       16505..16555
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS15990_0001"
                     /evalue="2.20E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="D6270_RS15990"
                     /protein_end="237"
                     /protein_start="220"
                     /score="17.2"
                     /tool="antismash"
                     /translation="VLFTSGTTGLSKGVLHS"
     CDS_motif       17084..17149
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS15990_0002"
                     /evalue="5.90E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="D6270_RS15990"
                     /protein_end="435"
                     /protein_start="413"
                     /score="15.5"
                     /tool="antismash"
                     /translation="PVGRLKVRGASLALGYHRRPEA"
     gene            17636..18946
                     /locus_tag="D6270_RS15995"
     CDS             17636..18946
                     /NRPS_PKS="Domain: Aminotran_1_2 (51-383). E-value:
                     9.6e-45. Score: 145.2. Matches aSDomain:
                     nrpspksdomains_D6270_RS15995_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609642.1"
                     /locus_tag="D6270_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_109164801.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.8e-43, bitscore:
                     145.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.1e-05,
                     bitscore: 20.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEPPPVSAPVSMSATLAADEALARRRRAGERVLSMASGEIGLPV
                     LPALRDRLAAAADENAYGSVAGSAALRTAVAGYWERRGLGIDPGLIVAGPGSKSLLFAL
                     LLAIGGDVIVPVPSWVSYAAQARLVGARPIPVPILPGQGGVPDPDRLREAVADARAAGQ
                     HPRAVVVTVPDNPTGTVASAATVRRLAQAARELDLVIVSDEIYCDLVYDSSGPAVSPAL
                     HAPERTVVTTGLTKNLALGGWRTGVARLPDSEPGRALHTRLTAVASQIWSSPPAPVQTA
                     AAYAFGEPPEVTERVAASRRLHETVVRAVAARFTAVGAQLAPVAATCYLYPDFEPLREH
                     LAQAHGVHGGDGLAALLSERYGVGVLPATAFGEAARPLRIRAATSHFYGETAERRRAAL
                     ESADPLALPWIRESVDRVGEVLADLTGTPVPAPAPHA"
     aSDomain        17789..18784
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS15995_Aminotran_1_2.1"
                     /evalue="9.60E-45"
                     /label="D6270_RS15995_Aminotran_1_2.1"
                     /locus_tag="D6270_RS15995"
                     /protein_end="383"
                     /protein_start="51"
                     /score="145.2"
                     /tool="antismash"
                     /translation="RLAAAADENAYGSVAGSAALRTAVAGYWERRGLGIDPGLIVAGPG
                     SKSLLFALLLAIGGDVIVPVPSWVSYAAQARLVGARPIPVPILPGQGGVPDPDRLREAV
                     ADARAAGQHPRAVVVTVPDNPTGTVASAATVRRLAQAARELDLVIVSDEIYCDLVYDSS
                     GPAVSPALHAPERTVVTTGLTKNLALGGWRTGVARLPDSEPGRALHTRLTAVASQIWSS
                     PPAPVQTAAAYAFGEPPEVTERVAASRRLHETVVRAVAARFTAVGAQLAPVAATCYLYP
                     DFEPLREHLAQAHGVHGGDGLAALLSERYGVGVLPATAFGEAARPLRIRAA"
     gene            19013..19963
                     /locus_tag="D6270_RS16000"
     CDS             19013..19963
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379932.1"
                     /locus_tag="D6270_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fumarylacetoacetate (FAA) hydrolase"
                     /protein_id="WP_109164800.1"
                     /transl_table=11
                     /translation="MPHSHLPVLFEALYGGERHVGFGRPEEGTQQTLYRVADGQVAAAF
                     IATDGSEGALRAALTEGAAAVVVTAGDPELRLLPPLLPQATGNALLSGFMGTHKKKWGG
                     QTAPDGGEFTPPKWFFKGFGDWVKLPGEDLVVPARPVALIEEPEIALVYVNDADGTPHY
                     AGYTFGNDLCDIGLHRQDPGYNPYCKLCDTALTPWLFLGPPPRTVTGRVTIVRDGTTAW
                     EGPFDCGDDALYHRIQDMADHLFTFPAVRRPGLVNYVLLGADEASFHDGFRIEDGDRIA
                     IDVKSHGVAFENQVRYVSPAPATTPAAAPAPVAAP"
     misc_feature    complement(19985..20000)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            20098..21540
                     /locus_tag="D6270_RS16005"
     CDS             20098..21540
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967625.1"
                     /locus_tag="D6270_RS16005"
                     /note="This protein belongs to a clade of FMN-dependent
                     monooxygenases, within a broader family of flavin-dependent
                     oxidoreductases, the luciferase-like monooxygenase (LMM)
                     family, some of whose members use coenzyme F420 rather than
                     FMN; Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="NtaA/DmoA family FMN-dependent monooxygenase"
                     /protein_id="WP_225976873.1"
                     /transl_table=11
                     /translation="MPATAKKQVHLAAQLPGIHNVTVWSDPRSESQIAIDSFIRLAQTI
                     ERGKFDFFFLAEGLRLREHKGQVYDLDIAGRPENLTVLSALAAVTTHLGLAATVNATFN
                     EPYEVARRFATLDRLSGGRAAWNVVTSYDAFTGENFRRGGFLPEADRYTRAAEFLTTTR
                     ELWDSWSTDDLKADARTGEFTAPGAGRFAHRGQHFDISGRFTTPPGPQGHPVIIQSGES
                     EAGREFAASDAEVIFSKHNRIDVARDFYRDVKRRLATYGRSPEDLLILPTANAVVADTD
                     EEAAAYAEEISRELVSPQTAIAHLEAVWGRDLSAYDPDGPLPDIEPEDDAHFLKGHSVF
                     RKGRAETARRWRKLAEERNFSIRELVIEVGGRQTFVGSPQTVADAIDDYVQTEGADGFV
                     LVPHLTPGGLDDFVDRVVPILQEKGVHRDDYTGTTLRDHLGLSTAPRPAGWGGPGQPLR
                     DERLRDQPLRDQPLRDQKETSA"
     gene            21537..22846
                     /locus_tag="D6270_RS16010"
                     /pseudo=""
     CDS             21537..22846
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609645.1"
                     /locus_tag="D6270_RS16010"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="LLM class flavin-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTGTTGPTGDTDPKGTQAGATDPKSAPATASGTPDGAPLHLAVAL
                     DGAGWHPAAWREEGARPGELLDAAYWAGLVAEAERGLLDFVTFEDALGLQSAAFHLPDD
                     RTDQVRGSIDAVLLAAHLAPLTTHIGLVPTTNVTHTEPFHLAIGIATLDHASKGRAGWR
                     PQISSRAADAAHFGRRTTPQLTEDDVTDSELISQPLRALFAEGAEVVEAARQLWDSWED
                     DAEIRDAATGRFLDRDKVHHIDFQGADFSVKGPSITPRTPRASRWW"
     gene            complement(22926..23864)
                     /locus_tag="D6270_RS16015"
     CDS             complement(22926..23864)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514049.1"
                     /locus_tag="D6270_RS16015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oxidoreductase"
                     /protein_id="WP_109164799.1"
                     /transl_table=11
                     /translation="MTSTSSASTTAPVTAAASGRWTLGDLPVNRIGFGTMRLPQTGGAL
                     VPDAVPRDRADALAVLRRAVDLGVNHVDTAAFYFSPLRSANELINSALAPYADDLVITT
                     KVGPARDGTGRWADHARTPEALRGQVEENLRQLGRDDLDVVNLRIVGTDSIAERFGALA
                     ELRQAGLIRHLGLSNVTPAHLAEAQAIAPVVCVQNRYGIGVRPEDDAFVRECGEQGIAF
                     VPFYAIAAAGGERGATGAEAAEVLAVAQAHGVSPAQVRLAWTLHRGPHVLAIPGTGDLD
                     HLAANVAAGALRLSEDELKLLETSHRRAAAG"
     gene            complement(24113..25056)
                     /locus_tag="D6270_RS16020"
                     /pseudo=""
     CDS             complement(24113..25056)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489678.1"
                     /locus_tag="D6270_RS16020"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="carbon-nitrogen hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLITAYNPPASPTRTRPAERAPLRVAVVQQRWHRDPAEHRAALR
                     EGIRLAAAEGARVVCLQELTLSPYFAVVRRADHPAPAGPEELLTGPTFTFAAEAAREHG
                     VYVHASLYEKAPAPGGQDDGLGYNTAILVAPDGTLAQRTRKTHIPVTEGYYEDDWFRAG
                     PAGDDAFPLVTVDEARFGLPTCWDQWFPELARAYSLAGADVLVYPTAIGSEPGFPGFDS
                     QPLWQKVITGNAIANATFMVVPNRIGAENGLTFYGSSFIVDPYGRVLAQAPATSPPSWS
                     RTSTSTPVVTGWSCSPS"
     misc_feature    25119..25132
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.39"
                     /tool="antismash"
     gene            25197..26324
                     /locus_tag="D6270_RS16025"
     CDS             25197..26324
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452156.1"
                     /locus_tag="D6270_RS16025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_109164797.1"
                     /transl_table=11
                     /translation="MTSRTVTLLDVARAAGVSKSTVSDALQGSGRVAEATRDRVRAVAE
                     ELGYRPNSAARRLRRSSTGAIGLHLPQTATRLDYYMNLAFGAVARAQEEGFDVVLLAPE
                     GASGGPVASRVDGLLVIDPEVGDSAVPGLLDAGVPVVTGERYLGPSAAPTGAVVCDNAA
                     SLTALLDHVTERGARRPAVLAPAGTSAWATALRTTAASWGQEHGVDVALRTVPFAATPG
                     EAEETTLALLRADPTVDAVICAPDGAAPGVLRAAAALGRTVGGASARSVGGPSARTVGA
                     TSARTSDSASGHAAGTGDGTGAQPRTPLLVASCVDGTATRSAEPPVTAVDLRPAAYGRA
                     CAELLCDILAGRAAPDTVRGHAWALETRPSTVTPT"
     gene            <26346..>26624
                     /locus_tag="D6270_RS33115"
                     /pseudo=""
     CDS             26346..>26624
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071025.1"
                     /locus_tag="D6270_RS33115"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="cytochrome P450"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRTVLQLSGDEHTVRRRALVAPAFRGSDLREKFLPVT"
     gene            complement(26830..27342)
                     /locus_tag="D6270_RS16035"
     CDS             complement(26830..27342)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D6270_RS16035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158650526.1"
                     /transl_table=11
                     /translation="MVLALLLAGVTAGCGTEAKREYGLPENLCEVPVKENAVDPVLPPG
                     KTLEQQAEPLEPPVSSCRVLVDKRRILFLSISQIDEFADPMGEREKEPFRNRKQMKDLP
                     FEGKGAIGDTNAMVAAECDSDASRYILVEFTVGEGLDEDTARRREKIDRFAKEYTKAVK
                     KAVSCIG"
     misc_feature    27463..27477
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
ORIGIN
        1 gtacggctgc ggccagcgcg cgggccgcct cgttgcggcg gccggtggtg aagcccgcgg
       61 ccgacacgcg tacggaggcg aggtgggcgg cgtacacggc gacaggcccc ttcggggtgg
      121 cggctgtggc ccgcatcgcc cgggtccacg gcatgatctc caccacggcc accgccgaga
      181 gccggtatct gctccagagg ccgacgccgc cgagcacggt gtggtgcggg taggcggcgg
      241 ccagctcgcg ctcgtagacc ggtgcggact cgtgtgacag ctccaccagg gccaggaggt
      301 cggccttggc cccggcgagg gcacgcgcgg tcccggccgg gtcggggttg gcctcgtcga
      361 cgttgtggct gaggacggtg aggccgtgtc cggtggaccg cttgtcgatg agggtggggc
      421 cgaggagcgt tgcccagacg agggcggggg cgagtacggc gacggcggcg agccgggagc
      481 ggcggacggc ggccagggcg aggaggacgg ggacggcgag accggtccag ggcaacaggg
      541 tctggaagag gctgccgagg ttgagggcgg tgtcggggag gtgtgcgtgc agggcgatga
      601 ggacggcggc gagcagcgcg gtgagggcga gccgtcggcc ggggggcttc ccggtggagg
      661 tgagggactc ctcggcgggg gcgtcggccc cggggctcgg gagctccggg gggctcaggg
      721 gctgcccggg gctcggggcc tgcccggcgc tcaggctcgg ggcggcctcc tgggtactcg
      781 ggctcggggc ggcctcctcg gtgctcgggg cctgcctggg gctcgcggtc tccccggcgc
      841 ccgggacggc ggtctcccgg gcgctcgggg cagcccccct ccccgggtcc tcctctgtgg
      901 tcagcacggc gcggggctcc ctacggtcac ggtcgcgtac accggaggtc gggtacgtcc
      961 ccagcctccg gggtccgcgc ttccggccgg tcaggggtgt gcttcgagga ccgcgcgggt
     1021 ctgtttcagc tgtgtatcgg ccggacaccc tccagtgccg tacgggcctg gcggcccgcc
     1081 tcctccgggt ccagccgtcc gcccctcgcg tacgcctccg agaacgccgc cgcccccagc
     1141 gcaccccgcg ccaccgccgt gatgcggtcc acgtcggcac gttcagcggg tggcagcggt
     1201 gccccggccc ggcggcgggc ggccgccgcc gcgcccagga ggacggccgc acgggtggcg
     1261 gcgggagcgt ggccgggcag ggcggccgca cccgcgaggc cctccaggga gagggccagg
     1321 gcgcggggct cggccagggc gcgggcgatc tccaggccct ggaggtggtg ggccgccgcc
     1381 ccgagcgcgt cgcctcgcag ctcggcgacg aagccgagct cggccaggag caggtggtcg
     1441 cccgcctggg aggagacgtc gccgtagccg tcgcggatgt ggcggaggtg ggcctcggcc
     1501 gcgtcgaggt cgcccgagcg gcgggcaccg agggcgaggc ccatctcgga gtggatctcg
     1561 ccgtacttgt agccctgttc ggcggcgatc cgacgcgcct gctcgtgcag gtcccgggcg
     1621 cggccccagt cgcgggagag cagcgcgagc cggccgagcc cggagagccg ggccgacacc
     1681 tccgcctcca gccccaactc ccgtgccatg agcagccctt cgtgctgccg gcgctcggcg
     1741 tcctcgtacg cccccttgat ctcggcaagc gcggcgagcg gcgagagggt ctgcaactca
     1801 ccccagaggt cgcccagttc gcggaagatc agggcgctgc ggcttccgtc gcggccgacc
     1861 ccggcgaggt cgccgcggac cagcgcgagc gtcgcgcgca gaccgagggc ggcggccgct
     1921 ccccaccggt cgtcggccgc ggtgaacagg gtgagggcgc gggcgttcag ctccccgctc
     1981 ccggccgcgt cacccgcgct gaacaggccg tacgcacaga gccagagcgc gcgggcccgg
     2041 cgtacggggt cggggatggc ctcggacgcg ggggcggtgc cagggccgtc cgccgtgccg
     2101 gcggctgcgg ccgggtcccc ggtgagaagg gtgaacgcgg cctggagcaa acccagttcg
     2161 ggcggcccgt ccgtcaccgc cagcaccgcg cccaggctcc ggcgggcctc cgtcaggcgg
     2221 ccgcgcagca gccaccacca ggccagcgcg gtggccagcc gggccgcctc ctccggctcc
     2281 cccgcccccg cccggcgtac cgcctcgtcg agtgccgtac gcaggttgcc ggcctccgcg
     2341 tccagccggg ccagccaggg ccgctgcccg gcgccgcgca gctggggctc ggcctgttcg
     2401 gccagggccc ggtagtggag gaggtggcgg tcccgtacgg cggtgaggtc ctccatctcg
     2461 tggagccgct cggtggcgta cgcggcgacg gactccagga gccggtagcg ggggccggtg
     2521 ggcccggcca ccacgaccac caacgaccgg tcgaccagcc gggtgaccag gtccagcacc
     2581 tcgtcccggg ccacgccgtc ccccgcgcag acggcctcgg cggcggccag gtcgcagccg
     2641 tcggtgtggg cggcgaggcg gcgcaggacg atgcgttcgg gcgcgctgag cagctcccag
     2701 ctccagtcga tcaccgcccg cagcgtctgc tggcgggccg gggcgccgcg ctgcccgaag
     2761 gtcagcaccc ggaaccggtc gttgagccgc tccgccaact cctctactcc cagggccctt
     2821 acgcgggtgg cggccagctc cagcgcgagc gggatgccgt cgaggcggcg gcagatctcg
     2881 gcgaccgccc ggcgctcgga ctcctccggc gcctccgggt cgcgcgggaa cccgggggcg
     2941 gcggcggccg cgcgctccat gaacatcctg accgcgtcgg cgggttgcag cggttccacc
     3001 aggaacatcg cctcgcccgc caggccgagc ggctcctgcc cggtggcgag gacccgcagg
     3061 ccgggggcgg tgcgcaggag gaggtcggtg agttcggcgg cggcgtcgac cacgtgctcg
     3121 cagttgtcca ggacgagcag ggtccggcgg tcgcgcaggg cggcggcgag gcggtgcggc
     3181 agggaggggg tggcggggcc ggtgccgggc agtgagcggg gggcgtcgtc gcggatgccg
     3241 agggtggcgg cgacgacctg ggcgaggtcg gcgggggtgc cggagcggat gccggcgaac
     3301 tccaccagcc aggtgccgtc ggccagttcg cccgcctgcg cccggtcccg cccggcggtg
     3361 gccgccgcca cggccagccg ggtcttgccc acgccacctg gtccggtgag ggtcaccagc
     3421 cttgcctctg cgaggagtcg ggacaggtcg gcgagggctt cgcgacggcc cacgaggggg
     3481 gtaagggggc ggggaggttg gagtggggcg gtgggatggc ggtggcgggt gcggtcggtc
     3541 cggggggcgg ggtgccggtc gcccgggcca cggcttcggt ggggggcgcc gcactcagcc
     3601 ccggctcctg ccgcagcacc gccccgtgca gcgcggccag ttcggggctc gggtcgaccc
     3661 ccagctcctc cgccaggcgg gtgcggaggt cctcgtacga cgcgagcgcc tcgctctggc
     3721 ggcccgccgc gtacagggcc ctcatctgga cggcgcgcag gcgctcccgc agcgggtgga
     3781 gtgcgacgag atcggccagt tccccggcga ggagcgtgtg gtcccccgcc tccaggcgcg
     3841 cccgggcctg ctcctccagc acggagagcc gctgctcagc gaggcgctgg gcggccgccc
     3901 gcacgaaggg gccgtccgcg aagtcggcgt acgccgggcc gcgccacagc tccagcgcct
     3961 cggtgagcag cgcggcccgg gcgcgcgggt cctggacggg gcgggcctgc gccaccaggg
     4021 cccggaagcg tacggcgtcc acctcgtcgc cgtcgtcgaa ccgcagccgg tagcccgggg
     4081 gttgacgcac cacgcggtcc cggccgatgg cccggcgcag ctgggagacc ttggcctgga
     4141 gcgcgcccgc gggcctgccc ggaggcgcgt cgccccacag gtcgtggatg aggcggtcgg
     4201 cggagaccgg ccccccgtcg ttcgcgagca gatccgccag cagcgcccgg accttggcct
     4261 cggggaccct gacttcccgt ccctcgccgt cccacaccgc cagtggcccg agcaccccaa
     4321 accgcatagg cgccaccgta caggtccggg caccggcccc cggggctccc gccacccacc
     4381 gcccccggcc cgaaggtttc ccgaaggttc cccgaagcgc cggggcgcag agtcgtcctc
     4441 gcgggcggta tcgcgatgcg accccgcggg cggcgcctgg agggagcggc aaccatgacc
     4501 aagtacgcgc gcagaaaggc cctggtcgtc ggcgaggcca ccgatatcgg cctggccatc
     4561 gccaagcggc tggtggaggg cggggcgagc gtcctgctga ccgcccgcac ggaggccgag
     4621 cgcgcccacg cggtcgccga actcggctcc gccgcccgcg tcgtttcgcc atccgccgtg
     4681 gaggccgccc tcaccggggc ccccggcccc gcaggtgccg acaccaacga ttccaccggc
     4741 ctaggggacg gcccaaccgg gctcggggac ggccccacag gcaccaccag gctcggggac
     4801 ggttccaccg ctcccaccgg cctcgtacac gaccccacag gcgccgctgg tgccatagac
     4861 cccacaggcc tcactagcac caccagcccc acaggcacca caggcaccag ccctacaggc
     4921 cccaccaccg tcggcctcct cttcgccgac gccatcccca ccgcgcgccc cctgctcccg
     4981 tacgtcgagg acggcggcgc ggtcgtcctg accgcgccca ccccgtgccc cgacgccgta
     5041 cgggcgctcg ccgacgaact cgccgcccgg ggcatccgcg tcaacgccgt ggcaccgggc
     5101 tgtatcgagg cgccgggctc cggcgccgta cccctgcctc cgctggggcg tctcggcgcc
     5161 gcagaggagg tggcccgcgc cgcgctcttc ctggccacgg aggcgacgtt caccaccggc
     5221 gcccggctcc ccgtggacgg cggcctcggc cacccatgac ccctctccgt ccccgcaccc
     5281 cacacctccc atccggaaac ctggagcaca ccccatgagc accgcacccg acacggcgcc
     5341 cgccgccgct gcggcaccgg accccaaggg cgggggcgag gaccagcaga agcttccgct
     5401 cttcgccctg ctggccctgg ccaccgccgt cttcatcacc tgcctcaccg agaccctccc
     5461 ggccggtctg ctgcccgcga tgagcgagga cctgcgggtg agccagtccg cgaccggcca
     5521 gacggtcacg gtctacgcga tcggcaccgc cctcaccgcg atcccgctca ccgccgccac
     5581 ggcgggctgg cagcggaaga agctgctgct cacggccatg gccgggttcg cgctcgccaa
     5641 caccgtgacg gccctgtcgt ccgtctacga gctgacgatg gtcgcccggt tcgtcgccgg
     5701 tgtcgccgcc ggtctcgcct gggccctgct cgccggctac gcccgccgcc tggcccccgc
     5761 acacctccag ggcaaggcga tggccatcgc catggccggt atccccgtcg cactctccct
     5821 cggggtgccc gccggaacgt tcctcggcga gtggctcggc tggcgcgtgg cgttcctgtc
     5881 gatgacggtg ctcacggtcg tcctgctggt gtggatcttc gtgggcgtgc cggacttccc
     5941 gggccagggg cgcggcgagc ggccgaagct gctgcggacc ctgaccatcc cgggcgtgac
     6001 cccggtcctg ttcgtcacgc tggtcttcgt gctggcgcac accatcctgt acgcgtacat
     6061 cgccacctac ctcaaggacc tgggcctcgg cagctccacc ggcctggtgc tcctcgtctt
     6121 cggggccgcc tcgctggcga gcatctggat cgtcggcgcg cagatcaacc gccggctgcg
     6181 cggtctcacc gtcggcggcg cgctgctggt cgccgtcgcc gcgctgctcc tggccgtcct
     6241 ctccgacacc accgccctcg tctatgtggc ggcggtgctg tgggggctgg gctggggtgg
     6301 tgtccccacc ctgctccaga ccgccgtcgg tgacgcgggc ggcgagtcgg ccgatgccgc
     6361 gcaggcgatg ctcgtcacgc tctggaacgt cgcgatggcg ggtggcggca tcgtcggcgg
     6421 catcctgctg gacaccgtgg gcagcgagtc cttcccgtgg acggtcctgc tgctcctgct
     6481 gccggtgatc gcggtcgtgc tctacgcccg gcaggccggt ttccccgccc accggccggt
     6541 ggcggaggcg gaggaggcgt cggccccggc cggcgtcccg gcccccaccg gcggcgaccc
     6601 ggcggcctga ggaagcgtgc ccggaccatg ttcatgattt gttgacactt caccgggcga
     6661 ccgcgggacc cggccccacc agtggcggag ccgggtcctt ccgctccacg cgcccgccgc
     6721 ctgcacccca ccgaggggtg ttttcgcagg tcagaccccg aactcgcaaa atagacggcc
     6781 gacccgggca aactcccttc cgggcggtac tttcacctcg tactgatgtg ccatgtatcc
     6841 actcgggtgc gagcggtgac gagtatcgag ggggcgtagc gttacatgtc gtcaagtgag
     6901 gtgcgcgcgg gggtgccggg cgacggcgca tacatgcaga cgttcatgga cgagatcttc
     6961 cgggccttcc agcggccgga gcagcgccgc tgggcccagg cctatctatg ggccctgatc
     7021 catgtatcag gcaagaagac gccccgccgc atggccctgg cgaagccctt gcccccggcc
     7081 gcggcacacg gcctgcacca gttcatcaac gccagcccgt gggagtggac cccggtacgc
     7141 cgccggctcg cccggcgggt cgccgcgcgg acgaccccgc acgcctggac cgtcgccgaa
     7201 ctcatcatcc ccaagcgcgg tgagcactcg gtgggtgtgc accggcgcct cgaccccgtc
     7261 accggacgca ccgtcaactg tcagcgggcg ctggtcttct tcctcgtctc ggggacccag
     7321 tgctacccgg tggactggag cctcgtgctc ggcggggcgt gggactcgga ccgggagcgc
     7381 agacgccggg cccgcatccc cggatccgag gccgggcgca cccctgccga ccatgtcgtc
     7441 gggtacgccg ccgaggccgc cgcacagccc caactcgccg ggctgccctg ggtgctggac
     7501 ctgacccggt gcgacgacgc ggcgggggtc ctcgcgggcc tcacccggca gcgggccgat
     7561 gtggtgtgcg aggtcgcccc gcaccacctg gtgctcctca ccgggcagca cacgcccgcc
     7621 gtgaccacgg tgagcgccct catggaggtc cggcacgccc ggcagaccca cgtcctgctc
     7681 cggcagaccc cggacggccg ggtccgtccc gtgccggtcc acacctacgc gggcacggtg
     7741 ggggcgcccc ggcccggctt cggcgacgac gtgggcgcac gcccgtaccg catcctggaa
     7801 cggcccgacc cggacggccg gcaacccgcc cggtactggc tcaccaccct caccgaccgg
     7861 cgggtggagg acgtcctccg gctggcgcgc ggccatgccg ccgccctctc ggccgtcacc
     7921 acgctcggcc gcaggttcgg cgtcctcgac ttcgagggcc gctccttccc cggctggcac
     7981 caccacatga ccatggcctc ggccgcctac gtctaccagc gcctgcccgg cgcatccggc
     8041 ggcggccccg ggggcgccgc cgccccgccg caagcaccgc cccgccgccg taacccgccc
     8101 gccccacccc ctccgtcgca ctcaccggtg cctccaactg acatggcagc accgcgaatc
     8161 gacgtgaagc cgaagagaag gggtgggtgg ggcagcatga gacaggtact cgtggtggag
     8221 caggacgcgg ccgcagcggc ggccatggtg agcgatctgc ggcggcaggg attcgccgcc
     8281 cgcagcgtct ccaccggaga gcgggcgctg cgcgtgtacg gcgacgcgga tctggtgctg
     8341 ttctccctgg agctgcccga tatcgacggg ctggaattgt gccgttccct gcgcggcggc
     8401 ggggatacgg ccctgatagc ggtcaccgat gccgacgccg aactggagcg cgtcctcgta
     8461 ctgcacgcgg gcgcggacga ctgtgtggtg agaagctggg gattcaggga ggtcggggca
     8521 cgtatcgaag cggtactgcg ccgggcccgg ccccggcaga accttccggg caccatttcc
     8581 ctgcgcgatc tgcatatcga tccgcgtcgg cgggaagtac ggctcggggg acggctcgtc
     8641 ggtgtcacgt cgaaggaatt cgaactgctc tacaccctgg ccgccacccc ggagacggtc
     8701 gtgacccgga aagagctgat ggcccgggtc tggggcagca actggggtca caccagccgc
     8761 acgatcgaca cccatgtgag cagcctccgg gcgaagctcg gctccggcgg ctggatcatc
     8821 acggtccggg gcgtcggata ccggatggga tacgcctggc agatgccgga gacgacggcg
     8881 ggctgagcgg accgggggcg agtggaccgg ggaccgagca gaccaggggc gagcggacga
     8941 gggacctgcg cggaccgggg ccgagcggac cagggacctg cgcggaccgg gcccactccc
     9001 ccggcccccg cccgtcacac cctcgccccc tccagccgcc gcagcagcgg gtggtgcgcc
     9061 tcgcccgtcg cccccaccgc ccgccgcgcc caccacgccg aggccaggtt cgaggtcagc
     9121 agggtgcggt gcggctcgcg gcgggccagc tcggtcagcg cggcgagcgt gcccatgccc
     9181 gtgcccgtga agagcaaggc cgtgccggcg ggcagctccc gctcccgtat ccgccgcagg
     9241 atggtcccgg tcgtcaccgt gtacgggtcg aagcgcgcgt ccccgcccgg gcgcgcggcc
     9301 tcctccgccg gcacgagcac caccccgtcg acggtgagcc cggccccctc ccagaaggcc
     9361 cgggaggtgt cggtgagcca gggctcgtac ggggagacga gcgtcaggcg gctcaccccg
     9421 agcgcctcgc aggccgcgag gatcgcctgg gtggaggact gcaccggcga gccggtccgc
     9481 tcggacagct cgtcgcagaa ggcccggtcg cccgccggct ccagcaggta gtgcgacgcg
     9541 ctgcacgcca ccaccgtggc atccagacgc agcgcgccga agctgccgag cagcccgggg
     9601 agcacctcgt tgtacgtctc cagcatggcc cggagttccg ctcccggagt caccgggaat
     9661 cgggaggtat acacattcat tccggcaccg agcagatggt tgaactcagg ttccgccgtg
     9721 gggttctccg gcggcacgac gacccccagc cggggcagcg agaagagatc catgcccagc
     9781 accgtagggc gtacgccgca ccaccgggtg ttcctcgtcc gctatttggc acgcccggac
     9841 gccacccttg cactgccttt ccttcctgac attccctgac actccgccac acagccctga
     9901 cacggttggc attgctcttt tcagccagcc gccgaaggat atggatcagc gaatgcagcc
     9961 ctgattgccc acccctttca cggagagagg agcaaaggaa atggcagcag aagaccctga
    10021 gaaactggag aggccgcccc gtatatcgga cgcgacgctg cgcgattccg cacacatggc
    10081 gggggtggaa ttcggccccg cggacgccgc cgccatcgcg gacctgctgg tgcggacggg
    10141 cgtcgaactc gtcgaggtgg ggatggtctc cggaccggac tccaaggacg ccgacctcgt
    10201 cctcgccacc cacgaggcgg tcacccccga gcgcagcatg acgctcgtcg tcgtacgcga
    10261 ccgccgccag gtcgcccgtg cgctggacga ggccgagcgc ctgggcgtgc ggcacatcat
    10321 gtactcgatc cccacctccg agcagcacgc gcagctgaaa ctcgactcgg cgagccccaa
    10381 gttccttcag gcgctggcac gttcggcgat ccagcaggcg aaggaccgcg gcttccacgt
    10441 cacgttcagc ggtgaggacg gcgcccggac gccccggggg cggctcgtcc cctatgtgga
    10501 ggcggggttc gcggcgggcg ccgaccggtt ccggctggcg gagaccgtgg cgtacctctc
    10561 gccctggcag atggaggagg tcatcgcgga catcaccgcg atcgacggct ccgagatcga
    10621 gatccactcg cacaacatgc tgggcatggc cgtcgccaac tccctggccg ccgtacgggc
    10681 cggtgcccag tggatctccg cgaccgtcgg cggcatcggg gagcgcggcg gcaacgcgcc
    10741 gctggccgag ctgctcacct cgctgcgtgt catccacggc gacacccgct tcgacctcac
    10801 ccatctcacc gagctgtccc ggatcgccct gcgcggcgcg ggcctcgggg aggccttcca
    10861 gtccgggccg accaccccgc acgccttcgc gtacgagctg ccgggccagc tgagccaccc
    10921 gcacgcgtac gagacgctgc ccgccgaact cgtcggcaac agccgcgagt tgcgcgtacg
    10981 cacccgcctc accaccgctc tcgtccgctg ggccctggcc gattcgggcc tggaggtcga
    11041 cgtcgacgcc ttcaccccgt ggctggccga gcggcaggag cgggacggcc gcccgctgct
    11101 ggaccgggac acgatccgca aggccgccat cgacttccgc ccggtgcccg cgtaacccac
    11161 ccccaccctc ccgaccgatc tacggagttc acgatgtcca ccgccaccct gaccggcgta
    11221 tgccccgagt gcgagaccga cctgaccgtc cccccggtcg ccctgggtga gacgctctcc
    11281 tgccccgagt gcatcctgac cctccgcgtc gaggccgtcg aggacggccg gctgacgctg
    11341 gagatggtcg aggtgcaact gcgcgactgg ggccagtgac atggcagcac tccgtcccgt
    11401 cgccctcgtc gcggaccgga tcgcttggga ggaacgcctg ctcatcgagg cggccccggc
    11461 cttcggcctc cgtatcgact gggtcaacga cgagtccctc tccctcggcc acccggacgc
    11521 cccgtcggtc aaggggtacg acaccctcct catccgcagc cgcagctaca cgcgcggcgg
    11581 cctgatcgcc accctcgccg aggcggccgg cgtccccacg ctgaacaccg cccgggccat
    11641 ccacgcctgc gagaacaagg ccgtcctgcg cgccctcctc cggaccgccg gcgtgccggt
    11701 ccccgaccac cggctcgtgc tctcccgcaa ggacttcgac aaggcgctgg ccgacctgcc
    11761 gctccccctc gtcctcaagc ccgtcttcgg cgggatgggc aagcgggtca cgctgatccg
    11821 gcacgccgac accgcccact ccgtgtacga ctacatcgag gacctggccc acgccttcga
    11881 gcaggccagt gtggtggagc cgtacctcgg cggcagctcg gtgcgctgcc tggtcgtcgg
    11941 gcgggagctg atcggggcgg cggagttcga gagcggcggc agcgactggc gcaacaacgc
    12001 ggccctcggc aacaagaacc gcgccatcgc ccacgacccc gatgtcgtca agatcgtcga
    12061 cggtgtggtc gacgtgctcg gacccggcat ctacggcgtc gacctcttcg ccacccccga
    12121 cggccatgtc gtcaacgagg tcaaccacgc ccccggcttc cgggccgtgg cctcggccac
    12181 cggtgcggac atcccctcgg ccatcgcccg tcatgtgcag gagctactcg catgatccgt
    12241 gcaggagtcg tcggcgcctc cgggctcgcc ggcggcgaac tcatccgcct catcacccag
    12301 caccccgacc tcgaactcac cttcctgggc ggctcctcca acatcggccg ccgcccctca
    12361 gagctccacc ccggcctccg cgacgaccgg ggcctgacca tccagccggt caccgaggag
    12421 gttgcggaga aggtcgacgt cctcttcctg gccaccccgg caccggtctc ggcggagctg
    12481 tcctcgctgc tcgccgaccg catcccggcc gtcgtcgacc tcagcggcgc gttccgcatc
    12541 cgtacgccgg agctgcacga ccgctggtac ccgaaggtca ggcgccgcac cgatctggcg
    12601 gaccgattcg tctacggcgt accggagctg atcggcgacc agttgaagga cgccgcactc
    12661 atctcgctgc ccggctgcta cgccaccgcg atcaccctgg gcctggcgcc gctcaccctc
    12721 ggtctcggac tcggcctgaa gacggtggtg gtggacggca agagcgggtc cagcggcggc
    12781 ggtgtccagc tgcgcacctc cgacctgcac ccgttccggg ccggggccat cgccccgtac
    12841 tccccgaccg ggcaccggca cgccgccgag gtcggcgact tcctggagcg gagcaagccc
    12901 ggcaccatcg ggaacctctc catgtcggcg tacggcgtcc ccaacgtccg tggcctgctg
    12961 accagttcgt acgtgttcac cgacgagaag gtggaccagc gggagctgaa ccgggactat
    13021 ctgcgcttct acaaggggcg ccgcttcgtc cgggtgcggc ggcacaacga gacgctgatc
    13081 ccggttcccg acccgcaggt ggtcctcggc tccaactatg ccgatgtcac cgtgctgttg
    13141 gacgaggagg gcggccggat cgtcgtgctc gccgcactcg acaacctggt caagggggcg
    13201 gcgggacaag ccgtgcaggt gacgaacctg cggttcgggc tgccggagga gacggggctg
    13261 acccagcagc cggtgatgcc ggcatgagcg catcctcccc tctccgcaca gtgcctacgg
    13321 tggtcaagct cggcggcagc tgcctcgacg acctcgacgg cacctggtgg gacgacctgg
    13381 cccggcacgg ccaggaccgg cccctagtcc tcgtgcacgg ctggtccaag ccgctcagga
    13441 gactcgacgc ccgctaccgc gagccgtccg cgatcctgcg cgaccggtac ggcaaccaga
    13501 gccggtggac tacccccgag gtcatcgacg acatcaaggc ggtcagcgcc gtcctggccg
    13561 aggacgtcct cgcacggctg gagagccgtg gcatcaccgc cgaacggctg ctcggcagcg
    13621 acggcctggt cagcgcggcc gagggcgagc ggtggtggtg gcgggagaag cggctcgtgg
    13681 agctggagaa cctcgtcggc ccgatcaccg gtgtcgaccc ggccccgctg aagaacctcc
    13741 agccgggcca cgcctacctg gtcaccccgc tcgcccggaa cgcggcgggc caggaggtca
    13801 acaccgacgc cgaccgggcc gccgccgcga tcgccggggc caccggcgcg tccgacctgg
    13861 tcctggtcac cgacgtcggc catctgctca tcgacgaccg gccggtacgc cggatcagcg
    13921 cggcggacgc cgccgccttc cgcgaccagg gcgccaaggg cggcatgcgc aagaagctgc
    13981 gggccgccgg cgaggccctg gaaggcgggg tggagcgggt cgtcatcggc agcgccgccg
    14041 tcacggagct gctggacggc tccaccggca cgctgatcac ccggtcggaa ggcggagagg
    14101 catgacgcgg tcccgtgtgc tggtcgtcaa caacggaacg ctgtcgctca ggcaactccg
    14161 cgcccgattt gaagagttgg gctcggatac ggaggcggtc gacgcctcct ccgtacccgc
    14221 ccgggtgggc ggccgctacc aggccatcgt gctgagcggc accaaggtgc gcgcgtacga
    14281 cagcgcgttc tacaagcccc tgatcgacct ggtcacgaca gcggacgtgc cggtcttcgg
    14341 catctgcggc gggatgcaga tcctcgccgt cgcggcaggc ggccgactcg cggaggggcc
    14401 gcagcgggtc ggcggctacg aggtgcgggt ggacacggag gagccgctct tcacctatgt
    14461 gaagcccacg gtcaccgtct tccaccggca caccctctac ctccaggagg ccccggcggg
    14521 ctaccgctcc atcggccgct ccgagcacgc gcccgtggag ttcctccgct cggacgacgg
    14581 ccggatccac ggcgcccagg cccacctgga gttccgcacg gacggcctgg agatcctgcg
    14641 gggcttcgcg cggctctacc agtgaccgag ccctccaccg acccttcgta caggacaagg
    14701 acttcgccat gagcgcagca gtaccggaag aaccgcagga ccccgccctc accgtccacc
    14761 tcaacggcag cggtggtgcc atcaagggat gggtggtcat cgacacactc gtcgacggcc
    14821 tggcgatggg cggcacccgg atgaccaccg gggtgagtga ggaggaagtc gccggcctgg
    14881 cacgggacat gaccgagaag ttcaccctgg ccgggctgcg catcggcggc gccaaggccg
    14941 ggatcgtcgc cgacggtacg aactccgggg gcgcggcccg cgaggagacc ttccgcacct
    15001 tcggccgcac ggtgaagccg cttctgcacg gcggcatcca cctcggcatc gacatgggcg
    15061 tcacccccgc cgaccgggcc gtcttcttcg aggaggcgga gtacgacccc cgctaccggc
    15121 tcggcgcccc cgacatgccg atcgactggc gtacgtacta cgagcccctg atcgacgcca
    15181 ccggccatgg cgtcggcgtc gccgcgatca ccgccctgga ggcgagcggc cgcaccgagc
    15241 ccgcccgggt ggtggtgcag gggttcggcg cggtgggccg ggcggtggcg cggttcctgg
    15301 aggaccgggg gcacatcgtc gtgggcatcg cggacatcca gggcacgatc agcgcggacc
    15361 ggcttccggt cgccgaactc gtcgccgtca ccgaccagtt cggcgcgatc gaccgcgccc
    15421 gcctgccgca ggacgtgaag ctctccggtg aaccggacgc ctggctggac gtggacgcgg
    15481 acatcctgat cctggccgcg cagaagtacg cgatcaacgc ggagaatgcc caccgactgc
    15541 gggccggcct ggtggtggag ggcgccaacc tcgcctccag cgcggcggcc aaggagaagg
    15601 tggccgcctc gggggccggg ctggtcccgg gcgtgatcgc caacatcggc ggcgccgcct
    15661 cggctgccct ggccgtcacc cgggtcgtcc cgttcgacct ggcggccgag gcgcgcaagg
    15721 cctgggtctt cgactgggtc ggcgaccggg tccgccggaa cacccgggac ctgctggaga
    15781 tcgcggcctc ccgggcgggc gacccgctgc cggagctgct ggcggcgcgc cggaaggagc
    15841 gctgatgagc acggcggcga gggagcggcc ggcccctgtc gccggggccg gtgcgcaggg
    15901 gcgcgccgga accgacgtgg agcgcgccga ggcataccgc cgtcggggct ggtggcggga
    15961 cgagaccttc ctcgacgatc tgcaccgcca ggcccgggag cacccacgcc ggctggccat
    16021 cgcgggccgg cgcgtggcgg agtcgcgtac ggacaccctc gactacgccg aactggaccg
    16081 tctgacgaac cggttcgcgc tggccctgct cgaactgggg ttgcggcgcg gggacttcgt
    16141 cgccgtacag ctgcccaacc ggtgggagat ggtgccgctg atcttcgcct ccatccgggt
    16201 cggcgcggtc atcatcccga tctccccgat ctgcacggag gaggagctgc gccaccgtct
    16261 cggcctcacc gaggcccggg tgtgcgtcac gctcccggag tggtccggca caccgctggc
    16321 ggagaccgcc acccggctga aggccgaact cccctccctg aagcatgtgc tggtggtgga
    16381 cggcccgccg cccgaaggcg cgctcccctt ccacgagcac ttcgtggcgc aggagcggga
    16441 ggagcgggaa ggcgccgccg cccggctgga cgggctggcg ctcggcgcgg acgacccgtt
    16501 cgtggtgctg ttcacctccg gcaccacggg cctgtccaag ggggtgctgc acagccagaa
    16561 cacggtgcac tcggcggtac gcggctacgt cgacgcgttc ggagcgggtg atggcgaggg
    16621 ccaggagtgg gtggcggcgg tctccacgcc actggtccac tactcgggct tcgcccaagg
    16681 ggtgttggcc ggggtcatgc tgggcgggac cgtcgccttc caggacgtac gccgtaacga
    16741 ggcgctcctg gacctggtgg agcggtacgg ggcgaccctg ctctacgggc cgcccgccac
    16801 cctcgccgat gtggccgcct cccagcgggc cgagcggcgg gacacgagca cgctgcggca
    16861 tgtggtgatc ggctcggcgc cggtcctcca ggagctggcg gacgaggtcc acgagacgct
    16921 cggcgcccgc gcccactcgc tgtggggcat gtcggagaac ggcccggtga ccaccacccg
    16981 gcccgaggac cctgagggct ggtcggcgcg gagcaacggc cgcgcgatcg acgcgatgga
    17041 gacccggatc gaggcgtcgg gtgcgtacgg gggctcggcg ggccccgtcg gccggctcaa
    17101 ggtgcgcggc gcgtcgctgg cgctcggcta ccaccggcgg cccgaggcgt tcgcggccga
    17161 gctggacgag gacggctggt tcgacaccgg cgacctcgcc cgggacgacg gccagggcgg
    17221 catccgcatc atcggccggg cccgggacgc ggtgctgcgg gacgggcggg tggcgccgat
    17281 gacggagctg gaggcggtga tcggcagcca ccccagggcg gaggaggcgg cgctggtggg
    17341 gctggagacg gccggcgggg agggccccgg caacgtgatc gtcgccgtgg tggtcccgcg
    17401 cggcggcccg ggcccgacgc tggaggaggt ccgggcccgg gtcacggatg cgggccacga
    17461 cgcccgcttc ctgccggacc ggctggaact cgtccccgcg cttcccaaga ccctcaccgg
    17521 caaggtccgc aaggcggaac tgcgggagcg gtacgcgacg agcccctcag ctccctgacc
    17581 cgtacacccc gttccttggc tttcaacacc cttaccgatc actggagtcg ctgtcatgcc
    17641 cgaaccccca ccggtctccg cccccgtctc catgtcggcg accctcgccg ccgacgaggc
    17701 cctggcccga cggcgccggg ccggggagcg ggtcctgtcg atggcgagcg gggagatcgg
    17761 cctgcccgtc ctcccggccc tcagggaccg gctcgcggcg gcggccgacg agaacgcgta
    17821 cggctccgtc gccggttccg ccgccctgcg caccgccgtc gccgggtact gggagcggcg
    17881 cggcctgggc atcgacccgg ggctgatcgt ggcgggcccc ggcagcaagt cgctcctctt
    17941 cgccctgctg ctggccatcg gcggggacgt gatcgtgccg gtgccgagct gggtgagtta
    18001 cgcggcccag gcccggctgg tcggggcgcg gcccatcccc gtaccgattc tgccggggca
    18061 gggcggggtg cccgacccgg accggctgcg cgaggcggtc gccgacgcgc gggcggccgg
    18121 gcagcacccc cgggcggtgg tcgtgaccgt gccggacaac ccgaccggga cggtcgcctc
    18181 ggccgccacc gtacggcggc tggcacaggc ggcccgcgaa ctggacctgg tcatcgtctc
    18241 cgacgagatc tactgcgatc tcgtgtacga cagctccggg cccgccgtct ccccggccct
    18301 gcacgccccc gaacggaccg tcgtcaccac cgggctcacc aagaacctcg cgctcggcgg
    18361 ctggcgcacc ggcgtggccc ggctgcccga cagtgagccg gggcgcgctc tgcacacccg
    18421 gctcaccgcg gtcgccagcc agatctggtc ctccccaccc gcaccggtgc agacggcggc
    18481 cgcgtacgcc ttcggtgagc cgccggaggt caccgaacgc gtcgcggcga gccggcggct
    18541 gcacgagacg gtggtgcgcg cggtcgccgc ccgcttcacc gccgtgggcg cgcagctcgc
    18601 ccccgtggcc gcgacctgct acctctaccc ggacttcgag cctctgcgcg agcacttggc
    18661 ccaggcgcac ggcgtgcacg gcggcgacgg tctggccgcg ctgctctccg agcggtacgg
    18721 ggtcggcgtc ctgcccgcca ccgcgttcgg ggaggccgcc cgccccctgc gcatccgcgc
    18781 ggcgaccagc cacttctacg gcgagaccgc cgagcggcgc agggcggccc tggaatcggc
    18841 ggacccgctc gccctgccgt ggatacggga gtccgtcgac cgggtcggcg aggtcctggc
    18901 cgacctgacg gggacgccgg tccccgctcc cgccccgcac gcctgatgtc accccgcccc
    18961 cacccgcgta ccccgtatgt cacacgcacc tcttacgtca taggagtcac cgatgcccca
    19021 ctcccacctc cccgtcctct tcgaggccct gtacggcggc gaacgccatg tcggcttcgg
    19081 ccgccccgag gagggcacgc agcagaccct gtaccgggtg gcggacggcc aggtcgccgc
    19141 cgccttcatc gccaccgacg gctcggaggg ggcgctgcgg gccgcgctca ccgagggtgc
    19201 ggcggcggtc gtcgtcacgg ccggggaccc ggaactgcgc ctgttgccgc ccctgctccc
    19261 gcaggccacg ggcaacgccc tgctgagcgg cttcatgggc acgcacaaga agaagtgggg
    19321 tggccaaacc gctccggatg gcggtgagtt cacgccgccc aagtggttct tcaaggggtt
    19381 cggcgactgg gtgaagctgc ccggcgagga cctggtcgtc ccggcccgcc cggtcgccct
    19441 catcgaggag cccgagatcg ccctcgtcta cgtcaacgac gccgacggca ccccgcacta
    19501 cgccggctac accttcggca acgacctgtg cgacatcggc ctgcaccgcc aggacccggg
    19561 ctacaacccg tactgcaagc tgtgcgacac cgccctcacc ccgtggctct tcctcggccc
    19621 gccgccgcgc acggtgaccg gccgggtcac catcgtccgg gacggcacga cggcctggga
    19681 gggacccttc gactgcggcg acgacgccct ctaccaccgg atccaggaca tggcggacca
    19741 cctgttcacc ttcccggcgg tacggcggcc cgggctggtc aactacgtgc tcctgggcgc
    19801 cgacgaggcc agcttccacg acgggttccg gatcgaggac ggcgaccgca tcgccatcga
    19861 cgtgaagagc cacggggtcg ccttcgagaa ccaggtgcgg tacgtctccc cggccccggc
    19921 caccaccccg gccgccgctc cggcgcctgt cgccgcacca tgaacacctc gtgaagtagg
    19981 gccggttgac ctgtgcagac gccagcggcc ccaggcacgc tctgagaacc gtccttcccc
    20041 acccgatccc cggctcgccc cccgcccccg ccggacttcc caggaggaga ccgcaccgtg
    20101 cccgccaccg ccaagaaaca ggtgcatctc gcagcgcagc tgcccggcat ccacaatgtg
    20161 actgtctggt cggacccgcg ctccgagagc cagatagcca tcgactcctt catccggctc
    20221 gcgcagacca tcgaacgcgg caagttcgac ttcttcttcc ttgccgaagg gctgcggctg
    20281 cgcgagcaca aggggcaggt ctacgacctg gacatcgcgg gacgccccga gaacctgacc
    20341 gtgctgagcg ccctggccgc cgtcaccacc cacctgggcc tcgccgccac ggtcaacgcc
    20401 accttcaacg agccgtacga ggtggcgcgc cggttcgcca ccctggaccg gctcagcggc
    20461 ggccgggccg cctggaacgt ggtcaccagc tacgacgcct tcaccggcga gaacttccgc
    20521 cggggcggct tcctccccga ggccgaccgc tacacccgtg ccgccgaatt cctcaccaca
    20581 actagggagt tgtgggacag ctggtcgacc gacgacctca aggccgacgc gaggacgggc
    20641 gagttcaccg cccccggggc cggccgcttc gcccaccggg ggcagcactt cgacatctcc
    20701 ggccggttca ccaccccgcc gggcccgcag ggccacccgg tgatcatcca gtccggggag
    20761 tccgaagcgg gccgggagtt cgccgcgtcc gacgccgagg tcatcttcag caagcacaac
    20821 cggatcgacg tggcccggga cttctaccgg gacgtgaagc ggcgcctggc gacgtacggc
    20881 cggagcccgg aggacctgct gatcctcccc accgccaacg cggtcgtcgc ggacaccgac
    20941 gaggaggcgg cggcctacgc ggaggagatc agccgggagc tggtcagccc gcagaccgcg
    21001 atcgcccacc tggaggcggt ctggggccgc gacctgtcgg cgtacgaccc ggacggaccc
    21061 ctccccgaca tcgaacccga ggacgacgcc cacttcctga aggggcactc cgtcttccgc
    21121 aagggccggg cggagacggc ccgccggtgg cgcaagctcg ccgaggagcg gaacttctcc
    21181 atccgggagc tggtcatcga ggtgggcggg cgccagacgt tcgtgggcag cccgcagacc
    21241 gtcgcggacg ccatcgacga ctacgtgcag accgagggcg ccgacggctt cgtcctggtc
    21301 ccccatctga cccccggcgg cctggacgac ttcgtggacc gggtggtgcc gatcctccag
    21361 gagaagggcg tccaccgcga cgactacacc ggcaccacgc tccgggacca cctgggcctg
    21421 tccaccgcac cccgcccggc cggctggggc ggccccggac agcccctgcg cgacgagcgt
    21481 ctgcgcgacc agcccctgcg cgaccagccc ttgcgcgacc agaaggagac ctccgcatga
    21541 ccggcacgac cggcccgacc ggcgacaccg acccgaaggg cacccaggcc ggcgccaccg
    21601 acccgaagag cgccccggcc accgcctccg gcacccccga tggcgcgccc ctgcacctgg
    21661 ccgtcgccct cgacggcgcg ggctggcacc cggcggcctg gcgcgaggag ggcgcccggc
    21721 cgggtgagct cctcgacgcc gcctactggg ccggtctggt cgccgaggcc gagcggggcc
    21781 tgctcgactt cgtcaccttc gaggacgcgc tcggcctcca gtccgccgcc ttccacctgc
    21841 ccgacgaccg caccgaccag gtcaggggca gcatcgacgc ggtactgctc gccgcccacc
    21901 tcgccccgct caccacgcac atcggcctgg tcccgaccac caacgtcacc cacaccgagc
    21961 cgttccacct cgccatcggc atcgccaccc tcgaccacgc gagcaagggc cgggccgggt
    22021 ggcgcccgca gatctcgtcc cgcgcggccg acgccgccca cttcggccgc cgcaccacac
    22081 cccagctcac cgaggacgac gtcaccgact cggagctgat ctcccagccg ctgcgggcgc
    22141 tgttcgcgga gggcgccgag gtggtggagg cagcgcggca gctctgggac agctgggagg
    22201 acgacgccga gatacgggac gcggcgacgg gccgcttcct ggaccgcgac aaggtccacc
    22261 acatcgactt ccagggtgcg gacttcagcg tgaagggccc gtccatcacc ccacgcaccc
    22321 ccagggccag ccgctggtgg tgagcctcgc gcacgccacg accccgtacg agttcgccgc
    22381 gctcagctcc gacgtcgtcg ccgtcacccc gcacgaccgg ccgggcgcgg cggcgatcct
    22441 cgcccaggtc gccgaggcgg tggagcgcac cggccggaac gtggtggaac gcccgctgcg
    22501 gaccttcgcg gacctcatcg tcttcctgga cgaggacccg ggcgcggccg cccgccgcaa
    22561 ggcccgcctg gacgacgtgg ccggagccga actggcctcg gacgccgagg tcttcaccgg
    22621 cacacccgcc gaactggccg acctcctcct cgactggcgc tccaccggcc tggacggctt
    22681 ccgcctccgc cccggcaccc tgccgcacga cctcacggcg atcacccggg gcctggtccc
    22741 ggagctgcaa cggcgcgggg tgttccgtac ggagtacacc tccaccacac tccgcgacca
    22801 cctgggcctg ccccggccca ccagccgcta cacgaaggcg ggttgagacg cggcgggggc
    22861 cgaggccggc gggtcgacga caaggccaac gggtcaccgg caaggacaga ggcgcaccgg
    22921 cagggtcagc cggccgccgc cctccggtgc gaggtctcca gaagcttcag ctcgtcctcg
    22981 gagagccgca gggctccggc ggccacgttg gcggcgaggt ggtcgaggtc gccggtgccg
    23041 gggatggcca gcacatgcgg gccccggtgc agggtccacg ccagccggac ctgcgccggg
    23101 ctcaccccgt gcgcctgggc gacagcgagc acctcggcgg cctcggcccc ggtcgcgccg
    23161 cgctccccgc cggccgcggc tatcgcgtag aaggggacga acgcgatccc ctgctcgccg
    23221 cactcccgga cgaacgcgtc gtcctcgggc cgcaccccga tcccgtaccg gttctgcacg
    23281 cagaccaccg gggcgatggc ctgagcctcg gcgaggtggg cgggggtgac gttggagagg
    23341 cccaggtggc ggatgagccc ggcctggcgc agctcggcca gggcaccgaa gcgctcggcg
    23401 atcgagtccg taccgacgat cctcaggttc accacgtcga ggtcgtcgcg gccgagctgg
    23461 cggaggttct cctcgacctg gccgcgtagc gcctcggggg tgcgggcgtg gtccgcccac
    23521 cgccctgtcc cgtcgcgggc cgggccgacc ttggtggtga tcaccaggtc gtccgcgtac
    23581 ggcgcgaggg cgctgttgat cagctcgttg gccgagcgca gcggggagaa gtagaaggcg
    23641 gcggtgtcca cgtggttcac accgaggtcc acggccctgc gcagcacggc cagggcgtcg
    23701 gcacggtcgc gggggacggc gtcgggcacg agcgcaccgc cggtctgcgg caaccgcatc
    23761 gtgccgaagc cgatgcggtt gaccggcaga tcgccgaggg tccaacggcc ggacgcggcc
    23821 gcggtgaccg gtgctgtggt gctcgcggag ctcgtggaag tcatgcctga atgatctccg
    23881 cccgtcgtgc ccccgtgcca tgaggtttcc ccgccgatcc accctgcggc ccgccggacc
    23941 tgagtcccgg agtctgcccc ctccgggcct gtggcccgcc ggacccgggt cctgaggccc
    24001 acccccctcc gggcctgagg cagaccgcac cccgggtccc gaggcccgcc ccgccggaac
    24061 tgaggcagac cggacccctg ccctgcggaa gcccccaggt cccgccggtc cctcagtccg
    24121 tcaccgtgag cgggccgtag gcgtccgggc ggcgggtggt caggaagggg aacagctcca
    24181 gccagtcacg acgggcgtcg aggtcgaggt ccgcgaccag gacggcgggc tcgtcgcggg
    24241 ggcctgggcc aggacacggc cgtacgggtc gacgatgaag gagctgccgt agaaggtgag
    24301 cccgttctcg gcgccgatcc ggttgggcac gaccatgaag gtggcgttgg cgatcgcgtt
    24361 gccggtgatc accttctgcc agagcggctg ggagtcgaag ccggggaagc cgggctcgga
    24421 gccgatggcg gtcgggtaga cgaggacgtc ggccccggcc agcgagtagg cgcgggccag
    24481 ctccgggaac cactggtccc agcaggtcgg cagaccgaag cgggcctcgt cgacggtgac
    24541 cagcggaaag gcgtcgtcgc ccgcaggacc ggcccggaac cagtcgtcct cgtagtaccc
    24601 ctccgtgacc gggatgtggg tcttgcgggt gcgctgggcg agggtgccgt cgggggcgac
    24661 caggatcgcg gtgttgtagc cgaggccgtc gtcctggccg ccgggcgccg gggccttctc
    24721 gtacagggag gcgtgtacgt acaccccgtg ctcgcgggcg gcctcggcgg cgaaggtgaa
    24781 ggtggggccg gtcagcagct cctccggccc ggccggtgcg gggtggtcgg cgcggcggac
    24841 gacggcgaag tacggcgaga gcgtcagctc ctggaggcag acgacccgcg ccccctcggc
    24901 ggcggcgaga cggatgccct cccgcagggc ggcgcggtgc tcggcggggt cgcggtgcca
    24961 ccgctgctgg acgaccgcga cgcgcagggg ggcacgctcg gcgggccggg tccgggtcgg
    25021 ggaggcgggc gggttgtacg cggtgatcag acgcatgacc agttccaggg gcgtgggacg
    25081 gcagggcgga cgaggaagat gccggaacgt tccggcatgg caccgaatct aaccctgccg
    25141 gaacgttccg gcaaccctcc acctcgtacg atcacgaccg tctagacttc acccccgtga
    25201 cctcccggac cgtgaccctg cttgacgtag cccgcgccgc cggggtctcc aagagcaccg
    25261 tctccgacgc cctccagggc tcggggcgcg tcgcggaggc gaccagggac cgggtccgcg
    25321 cggtggcgga ggagctcggt taccggccca acagcgcggc ccggcggctg cgccgctcca
    25381 gcacaggggc gatcgggctg cacctgccgc agaccgcgac ccggctggac tactacatga
    25441 acctcgcctt cggagccgtc gcgcgcgccc aggaggaagg gttcgacgtg gtgctgctcg
    25501 ccccggaagg agcgtccggc gggccggtcg cctcgcgggt cgacgggctg ctggtgatcg
    25561 accccgaggt gggcgacagc gctgtgccgg ggctgctgga cgcgggcgtt ccggtggtga
    25621 ccggggagcg ctatctcggc ccctccgccg cccccaccgg tgccgtggtc tgcgacaacg
    25681 ccgcctcgct caccgcactc ctggaccacg tgaccgagcg aggcgcccgc cgccccgccg
    25741 tcctcgcccc cgcgggcacc tcggcgtggg ccaccgccct gcggaccacc gccgcctcct
    25801 ggggccagga gcacggggtg gacgtggcgc tgcggaccgt accgttcgcc gccaccccgg
    25861 gcgaggccga ggagacgaca ctcgccctgc tgcgggcgga cccgacggtg gacgcggtga
    25921 tctgcgcccc ggacggcgcg gccccgggcg tcctccgggc ggcggcagcg ctgggccgta
    25981 cggtgggcgg cgcttctgcc cgttcggtgg gcggcccctc tgcccgcacg gtgggcgcca
    26041 cctctgcccg tacgtctgac agcgcctcgg gccatgcggc cggcacgggt gatgggaccg
    26101 gggcccaacc ccgtaccccc ctcctcgtcg cctcctgcgt cgacggcacc gccacccgct
    26161 ccgccgagcc gcccgtcacc gcggtcgacc tgcgccccgc cgcgtacggg cgcgcctgcg
    26221 ccgagctgct ctgcgacatc ctggcgggcc gcgccgcccc cgacaccgtc cgcggccacg
    26281 cctgggcgct ggagacacgg ccctccaccg tcacacccac ctgagcggtg gagcgacacc
    26341 acggacacgg ccgcacggtc ctccagctca gcggggacga gcacaccgtg cgccgccggg
    26401 cactggtggc gcccgcgttc cggggcagtg acctgcggga gaagttcttg cccgtcactt
    26461 aacgggattg gcgcgagctg accgacggtt tccgtgcctc cgggtcggtc gacctggtcg
    26521 ccgaccacgc gagccgtctc ccggtcaatg ccatcgccga catgccgggg ctcgacaggg
    26581 ccgacaacgc gcgatccccc ggccggtaca cagctgtcat cgccagcggc acgaagagcc
    26641 tgccgctccg cttccgcccg gtggccggtc gacggcggtc aggtggcgca gccgtactgc
    26701 ccggtcccgt cccacgatga ccaccggcgg gaccttgaga gtgaccgtgc cacaaggccg
    26761 gtcggaccgc ctcatcttcg acgcgcgccc ggccggcggc tgaacctcac agcgcgcccg
    26821 ctcgcgcagc tatccgatgc acgaaaccgc cttcttgacc gctttcgtgt actccttggc
    26881 gaagcgatcg atcttctcgc gacgccgagc cgtgtcctcg tccaggccct cgccgacggt
    26941 gaactcgaca aggatgtagc gggaggcgtc cgaatcacac tctgcggcga ccatcgcatt
    27001 cgtgtcgccg atcgcgccct tgccttcgaa cggcaggtcc ttcatctgct tccggttccg
    27061 gaagggttcc ttctcccgtt cacccatcgg atcggcgaac tcgtcgatct ggctgatgga
    27121 caggaacagg atgcgacgct tgtccacgag gacacggcag gagctcaccg gcggttcgag
    27181 cggttcggcc tgctgctcaa gggtcttgcc cggcggaaga acggggtcga cggcattctc
    27241 cttcacgggg acctcgcaga gattctccgg aaggccgtac tctcgcttcg cctccgtacc
    27301 gcacccggct gtcacgcccg cgagcaggag ggcaagcacc accgaggcgg tcctggggaa
    27361 cctgttcact acttctcgcc tccgaccccg tcggccttgt gatttccgtg gtccgccgcg
    27421 tccctgatct gggtgtagac gcctcggtcc ttggagaagt ccttctcgtt ctgagcccac
    27481 tcggaattct ccgcgtacca gtgatcggcg atggcccgga gctggaggtt gcgctcctcg
    27541 tgattggcct tacggtcgtc ggtggctttc tcgccgat
//
