LOCUS       NZ_CP032543            21062 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3476718
            Orig. end                         :: 3497780
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21062
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="15"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21062
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21062
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11062](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11062
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(1207..1677)
                     /locus_tag="D6270_RS15475"
     CDS             complement(1207..1677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156416.1"
                     /locus_tag="D6270_RS15475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2269 family protein"
                     /protein_id="WP_109164884.1"
                     /transl_table=11
                     /translation="MTKFFLSLHVIAAVLAIGPVTVAASMFPKALRRAHAAPEDREAYA
                     ALRLLHRICRVYAVVGTAVPVFGFATASSLGVLGSAWLVVSIVLTAAAAAVLALLILPA
                     QDRALTAASPPEADVSVHRVAGRLAMLTGVFNLLWATVTVLMIIRPGSTTGA"
     gene            complement(1674..2021)
                     /locus_tag="D6270_RS15480"
     CDS             complement(1674..2021)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064929.1"
                     /locus_tag="D6270_RS15480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109164883.1"
                     /transl_table=11
                     /translation="MTTTGPVTGIWDLSISTPIGRIAAVVELHDNEGSLTGSARGAGEE
                     VPLDGLILTGDRLTWKQAVTRPMRLNLAFDVTVTGDTLAGTSRAGRLPASRVSGVRRTD
                     RAAETVPGPRS"
     gene            complement(2096..2812)
                     /locus_tag="D6270_RS15485"
     CDS             complement(2096..2812)
                     /EC_number="4.2.1.-"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064928.1"
                     /locus_tag="D6270_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_109164882.1"
                     /transl_table=11
                     /translation="MHAQIVLFDGFDPLDVVAPFEVLHAGGTASGGAVTVKLVSAEGAR
                     EVVSGAGGLTLRATAALDPERADLVLVPGASGRVGEPEDGEVSGEAPTYGGVAAAAPGE
                     VIDQPVPVLLGRTLATDLPALLRAAMDDPSVTVATVCGGSLVLALAGLLEGRHATTHHL
                     GIDLLDATGAHAVRARVVDDGDLVTGAGVTSGLDLALHLLEREAGPRIAHAIEELFAHE
                     RRGTVWRAQGPVPAAL"
     gene            3036..3974
                     /locus_tag="D6270_RS15490"
     CDS             3036..3974
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719994.1"
                     /locus_tag="D6270_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_109164881.1"
                     /transl_table=11
                     /translation="MHTVAVLALDQVIPFDLSTPIEVFTRTRLPDGRPGYQIRVCAERP
                     EVDAGAFTLRAPWGLDGLTGADTIIVPGTATPTAPLSPAVRDALLAAARAGTRIASICS
                     GTFPLAATGLLDGLRATTHWLAADLLAAAHPEIEVDPDVLYVDNGRLLTSAGAAAGLDL
                     CLHMIRRDYGSAVAADAARLSVMPLEREGGQAQFIVHDYAPAPQGHALEPLLAWLQENL
                     ATELTLADIAARAGMSTRTLMRRFREQTGTTPLQWLHRARIRQAQHLLETTDHSVERIG
                     SQVGFGSPTAFRDRFRRTTGVSPRAYRRTFA"
     gene            4208..4750
                     /locus_tag="D6270_RS15495"
     CDS             4208..4750
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609527.1"
                     /locus_tag="D6270_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_109164880.1"
                     /transl_table=11
                     /translation="MATGRTDPDRRDRIIDAALDLIADEGVAGMSHRKVAARAGVPLGS
                     MTYHFTSMDELLHEAFTRFSGTIVAVFEDRLGAATTPDEAREAVADLVHHLSGGNQREL
                     ILTHELYTLAARKPAYRELTRTWMSRSRRALEWHFDPATARQLDALIEGLSIHRALETE
                     PHDRALTVEAIARITTL"
     gene            complement(4961..5221)
                     /locus_tag="D6270_RS15500"
     CDS             complement(4961..5221)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D6270_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158650524.1"
                     /transl_table=11
                     /translation="MSRRAWVLTWAVLCVAGLTATVWLRAAPEVRPERHIKAECRAYIA
                     EIEGRIRAARSGSKGEGGIVAFSRDRTDCADELDDLLRDGG"
     misc_feature    5178..5198
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.56"
                     /tool="antismash"
     gene            complement(5281..6854)
                     /locus_tag="D6270_RS15505"
                     /pseudo=""
     CDS             complement(5281..6854)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379865.1"
                     /locus_tag="D6270_RS15505"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQRLARNGGSAELLRWLAGRADGWAGIASSDGTSLSASGTVSGGG
                     PGTVSGGTGSATGGAGGADGFGIPDVTALVAEGVQALTERGALAFSRDTGAHTLLLFPL
                     PGYDPHGEDRAAAPVLAVVTPRPVAAGLATLLADALMPLSLCWEAEAVERKRRRVDLAE
                     SRGREAVLHLLMTGQLPIAQQMAGALRPRLPDPVRVGVVECPGDRRDEVARVCARADGG
                     RSWIVRCPVYARHLILVMPAEDGPDQGAATDEAVAALVEGCVVGVSERVPLADTATGYR
                     QAFHALAVARELPTRHARFDLAPEPALVVGHVGRQWAEGLLTPLLTHVPRRAQDPGSQE
                     LAATAASWLAFSSHATDHLKVHRNTLAARLRLIGELLGLDLRRLADQSALDLALRIRST
                     PAPVCTTAPGETERTASSGQRDGGAARALDLDEVLRRPAVQGWAARQLAPLAAPVGGPA
                     EETLRAWLRCEGRLGPTAAELGISVPGARKRLTRLETVLRRSLLRPRAPATTCGWRCGR
                     GSWRLLR"
     gene            7143..8261
                     /gene="dnaN"
                     /locus_tag="D6270_RS15510"
     CDS             7143..8261
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514146.1"
                     /locus_tag="D6270_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA polymerase III subunit beta"
                     /protein_id="WP_109164877.1"
                     /transl_table=11
                     /translation="MEFRIECSALTEAVAWAARVLPVRSPVPVLSGLLLDTEGGRLRVS
                     GLDYEASARIDVAAAEVVRPGKVLVMGRRLLDICKVLPEGPVECAVEGSRFTVSGDGAR
                     FGLSVLPLDDYPALPALPQVRGAVEADRFAAAVADVAVAAGRDDTLPTLTGIRLGLDGE
                     SGTMTLAATDRYRFAVRTLPWQAAADDESADVVVSARRLTEIARSLGRSGLVSVALDAG
                     SAGFEHAGMRTTVRLLDGRLPRHDKLFALESPAVAVVDRPRLVEAVKRVSVVADGDGPV
                     QMTFSAADNSVHLQAGYEDDVASQRLPATLDGAPEMTVAFNPGYLADALASFEEPTLRL
                     LMMGAGQRAMITGGEGSQAHRHLLMSVRPPLV"
     gene            complement(8392..9279)
                     /locus_tag="D6270_RS15515"
     CDS             complement(8392..9279)
                     /GO_function="GO:0004568 - chitinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006032 - chitin catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0016998 - cell wall macromolecule catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452937.1"
                     /locus_tag="D6270_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 19 protein"
                     /protein_id="WP_109164876.1"
                     /transl_table=11
                     /translation="MIKRALGLLVALAAVVAAFVVLPAATAQAATCVAAWNSSAVYTGG
                     QTASLNGRNYTAKWWTQNERPGSSDVWADNGACGTGGGDGPGQSNGFVVSEAQFNQMFP
                     NRNSFYTYQGLTDALSAYPAFANSGSDEIKKREAAAFLANVSHETGGLVYIKEVNEANY
                     PHYCDAGQPYGCPAGQSAYYGKGPIQLSWNFNYKAAGDALGIDLLNNPYLVEQNASIAW
                     KTGLWYWNTQTGPGTITGHNAIVNGPGFGETIRSINGAIECNGGNPAQVQSRIDKFTQF
                     TQILGTTTGSNLSC"
     misc_feature    complement(9352..9367)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.22"
                     /tool="antismash"
     misc_feature    9368..9383
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.91"
                     /tool="antismash"
     misc_feature    9477..9490
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    9517..9528
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            9721..10008
                     /locus_tag="D6270_RS15520"
     CDS             9721..10008
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240940.1"
                     /locus_tag="D6270_RS15520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109164875.1"
                     /transl_table=11
                     /translation="MERATDTREGIGGPGGQAVLLAAGLADLAVTTVGAAFTSVRGLLR
                     RSDTAELAAGAEQDLIARGRLALDRYATTPPAHLEVLARHVIAQRDGERV"
     gene            10001..11062
                     /locus_tag="D6270_RS15525"
     CDS             10001..11062
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240939.1"
                     /locus_tag="D6270_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_109164874.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.9e-35, bitscore:
                     118.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEGWEPGAFKARVDQVLHRFAAGEAGQLTAIDASLGPVADAVET
                     AVAEGKRLRAAFCYWGWRAAGQPDSDALVRAAASMELVHAAAVVHDDLIDDSPLRHGRP
                     TAHLALREAVRGHPEPTSAARSLAMLAGDLLMSMAGQLFVTSGLPAGYLGRARPLWASL
                     ARELVAGECLEILHTGAAVPDTATSLKVVRYKTAKYTVEQPLLIGALLGGAGGPLRAGC
                     SAYGLPLGEAFQLRDDLLGLFGDPALTGKDGSDDVRGHRPTALLAETWRLAGEEDRARL
                     RTLLAPGTDTRTTGTADAVRDIMRRLKAPDRIESMITARAEEALRTLDELDLPAPAVTA
                     LTALAHSAAVRRH"
     gene            11107..12288
                     /locus_tag="D6270_RS15530"
     CDS             11107..12288
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514140.1"
                     /locus_tag="D6270_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_109164873.1"
                     /transl_table=11
                     /translation="MTSAPAYTQASLDALRQSGDELADATVATLFERGEVGTFNTLMRY
                     VSTAGAPLPDGLPDVARDYLNATAAPPSWVDWSEMEKARLFFIDNNVHISTALSFAAMP
                     ACYVVPHVAKLLSATHGLNYPSKRMAETGQFTVHLMQPDAFEAGSRFIPAAQKVRLLHA
                     SIRHHLRREGAWDTEGAGMPICQEDMIGGQMFFSMLVLDSLHRLGIHMSEEGADAYYYA
                     WRVVGAMLGVDQKAVPKSLAEAREFLDLYMIRHMGPSPEGALLTRQLIDLYEEVVPGTF
                     FDPIVSALIRHLVGDTCADWLEVPRTPWDTVAKAVPHLLGVLETIEDRSPLGAWALDRI
                     GHLTTVLELSSLTRGRVMHYAIPEHLKKEYGVPSGPARTGRWSPPAATVPGPR"
     misc_feature    complement(12331..12348)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            12454..13983
                     /locus_tag="D6270_RS15535"
     CDS             12454..13983
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514139.1"
                     /locus_tag="D6270_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_109164872.1"
                     /transl_table=11
                     /translation="MEWFSAENVVAVLTAVLGVLASIGVLWYERRVPRRKRVGYRVQMD
                     TPIGSDVSQGRANVRLGLFSETPDMSDATLVLLRVENDGSQSIVDSDYTGRELHGLTAE
                     FTGRTVRGIAVTQPPGAVHLMEHFTPAAGVRHTGSLIRLPRVPLNRGEHFKLLVLLTGG
                     DVGSPIRITGGIRDGEVMVNRAARPDDKPPLFGRAARLITVTLTVCVVVLAAIILVRDD
                     TPPPLDCARGQLRVTGSTAFAPVVRELATTYMKECEGSRIEVDPHGSNSGIRELSDEGA
                     RSAKGGSPALVALSDGPKPPGHPELRETRVAVSLFSLVVNDRVPVRDLALADIRRIYAG
                     EIRNWRELGGPDLEILLVSRDANSGTREVFQRRVLDRNEPAQSSRDCATKDDPRAPVVR
                     CELDGTDQVLATVARLDGALGYSELRAGSEPRGLHRISIDGAHPSVDTIGTSPYPYREI
                     EYAYTYGRPPADSLASSFLGYLSRGRGQDVIHIHGHLPCATPKGLRVCGED"
     gene            complement(14065..15348)
                     /locus_tag="D6270_RS15540"
     CDS             complement(14065..15348)
                     /EC_number="6.3.4.4"
                     /GO_function="GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975310.1"
                     /locus_tag="D6270_RS15540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenylosuccinate synthase"
                     /protein_id="WP_109164871.1"
                     /transl_table=11
                     /translation="MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVV
                     GDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNERGVDTSKLLISGNAHL
                     ITPYNVTVDKVSERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILEQKVEAA
                     LEQKNQLLAKVFNRRAIEAGKVVEDMLQYAEQIKPFVADTTLILNDAIDEGKVVLFEGG
                     QGTLLDVDHGTYPFVTSSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTEL
                     HDEDGEALRRIGGERGVTTGRDRRCGWFDAPIARYATRVNGLTDFFLTKLDVLTGWEQI
                     PVCVAYEIDGKRVEELPYNQTDFHHAKPIYENLPGWSEDITKAKTFDDLPKNAKAYVKA
                     LEEMSGAPISAIGVGPGRTETIQINSFL"
     gene            15535..16386
                     /locus_tag="D6270_RS15545"
     CDS             15535..16386
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609548.1"
                     /locus_tag="D6270_RS15545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diacylglycerol kinase"
                     /protein_id="WP_109164870.1"
                     /transl_table=11
                     /translation="MSAAEPPGDGGDQLLVVIDPVARRTDGESVRIAKDVLSAGSHAKI
                     CLPDTPEEFARALSRRGARRPVVVGDDHALLRAVAQLHRERELAAGVLSLIPVGAAHAL
                     EVAHALGVPRGAVAAARTALDGAVRRLDLLVDDSDGVVLGRLRIPAPTLLADAPHTGVT
                     AVWDTCRSLMTSLVRPAAPGGATAPPGTHRLRVEADGVLLSDLDAPVRGVSVLSQGDGG
                     LADVVVRTSDGEDVTVEAKAVTVSGADFRYRADIQTGGPVRTRTWTVRAGAWGLMLPVP
                     AS"
     gene            complement(16638..17842)
                     /locus_tag="D6270_RS15550"
                     /pseudo=""
     CDS             complement(16638..17842)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379872.1"
                     /locus_tag="D6270_RS15550"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHVSFDPWSPAFVADPYPAYAALRAAGRAHWFEPTGQWLIPHHSD
                     VSALLRDRRLGRTYLHRFTHEEFGRTPPPAAHEPFTTLNGQGLLDLEAPDHPASGGSSP
                     RPSPRVRSRTSLRPYGGWRPGWSTRSWPRAAATCWRRWPNRCPSP"
     misc_feature    17959..17975
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            complement(17976..18638)
                     /locus_tag="D6270_RS15555"
     CDS             complement(17976..18638)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019766165.1"
                     /locus_tag="D6270_RS15555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_109164868.1"
                     /transl_table=11
                     /translation="MSDIRVLIVDDQMMVREGFSVLLNAMPGITVVGEAVDGREAIDKV
                     TALFPDVVLMDIRMPGMNGIDATREIVAQVVDAKVLVLTTFDLDEYVYQALRAGASGFL
                     LKDASARQLADGVRVVASGEALLAPTVTRRLITEFSKLAEAPRPPALARVGDLTERETE
                     VLVLIAQGLSNAEIASHLIVAESTIKTHVSRILVKLGLRDRTQAAVFAYEARLVTPG"
     gene            complement(18635..19975)
                     /locus_tag="D6270_RS15560"
     CDS             complement(18635..19975)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489566.1"
                     /locus_tag="D6270_RS15560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_109164867.1"
                     /transl_table=11
                     /translation="MTETQTKTSSPELRAAEGAMEGLREDLFRHVFAYRPLPPLSPEGR
                     FIRRLPEGVRRLVVWTPHALVLGAALIVLLAGLANWHFRFLMGLVPAIAVAMTLVRPVA
                     AFWGSMLAAVFCAVLGSDGLWGPSAFIAQVVVMVVVAARTRPRTGAWMWLMTLLFGLLL
                     EGGDPSITAPMAVLSAFALLVVAMLQVRRDAAQEVREAEREVTVQRTVTAVERDRRTLL
                     EERTTIARELHDVVAHHMSVVAIQAEAAPYRVENPPPELEQAFVTIRENAVAALTELRR
                     VLGVVRAEDYEAPDAPQPTLAVLDGLLDNVRETGLETEKVVTGAVRELPQGVELSAYRI
                     IQEALSNTLRHAPGATARVEIAYVLGGLGLRIVNGPPRGLVKPSPGAGHGITGMRERVA
                     MLNGEMTAATTEDGGYEVAVFLPVPPAEGEPDAPAADLLPYKKADGA"
     gene            complement(20139..20564)
                     /locus_tag="D6270_RS15565"
     CDS             complement(20139..20564)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126327.1"
                     /locus_tag="D6270_RS15565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_109164866.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3e-05, bitscore:
                     21.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILVTGATGTVGLRVVEQLLERGEHVRAVTRDPARAEFPAGVDV
                     VRGDLADPASLESALEGVAGLHLITFDGGLSAPLTTGEEIMERARAAGVRRVTVLNGGG
                     DIPPEGRAVIDTVEKVTGRPARTFARWAGEHAEFFRS"
ORIGIN
        1 gccaggaagc ccagcgaggg cgggccgacc aggaacgccg cgtacccggc cgtcgagacc
       61 gccgcgaccc gggccgaagc ctcccgctcc cccttcccct cgcccgccgc cgagaccgtg
      121 accgggaagc ccagcgaggc gccgagcccc cacagcacga ccgccgcccc ggcgagcagc
      181 gcgctggagg agaacaccac cagcgccaca cccgccgccg ccacgagcgc gctggcccgc
      241 accacggccg caggcccgta ccgcaccagc agtggcccgc ccgcgaaccg gcccgtcgtc
      301 atcgcgacgg cgaacagcat gaacgtcagc gaaccggccg tcgcgctcgt cccgtggccg
      361 tccaccatca gcagcggcag ccagtcgttg gccgacccct ccgcgaacgc catggccagc
      421 acgatcagcc cgatcagcac cagccgccgg tcccgccaga cctccacctg cgcgcgccac
      481 ccaccgcccc cggcccgctc gcccaccgcc gtgtccgccg cctcgcggcc tgtgcccgcc
      541 ggaaccgccc gtacggtcca caccccggcc gccgtgaccg ccgcggccac cgccgcgagg
      601 tgccagccga ccgggaaacc caccgccgtc agccccatcc cgagcagcgc gcccaccacc
      661 gtcccgaggc tgaagcagcc gtgcagcacc ggcaggaccg ggcggcccac ggtccgctcc
      721 acggcggcgc cctcgatgtt gaacgccacc tccgcaagcc ccatcccggc cccgaacagg
      781 gccagtccgc cgaagacccc gccggagacc tccagcgccg cgcccccggc gaccaccagc
      841 agcccggcga cgagcagcgc cgcgccgagc gtgatcaccg cgcgtccgcc gtgcttgcgc
      901 acgaggccgc cggagaccag cacgcccgcc atcgaaccga tcgagagccc gaacagcacc
      961 aggcccatcg accccgtgga cacgtccagc gcgtcacgta cggcgggggt cctggccacc
     1021 caggaggcca tgctcacccc ggtggcgagc atgaagagga agagcgcggc gcgccagcgg
     1081 cgggtgcggg cgtcgatgac cggcgtggcc ttcatgagca gggtgcctcg gcagacgggg
     1141 agggggcgga cgggacgtgg agcgtacgat cgtacgccta aagcgtacgt tcgtacacac
     1201 cccgtctcac gctcccgtcg tggagccggg ccggatgatc atcaggaccg tgaccgtggc
     1261 ccacagcagg ttgaacacac cggtgagcat ggccagtcgg ccggcgaccc ggtgcacgga
     1321 gacgtccgcc tccggggggc tcgccgcggt gagcgcgcgg tcctgggccg ggaggatcag
     1381 cagggccagt acggcggcgg ccgcggcggt caggacgatc gagacgacca gccaggcgct
     1441 gccgagcacg ccgaggctgc tcgccgtggc gaacccgaag accggtacgg cggtcccgac
     1501 gaccgcgtag acccggcaga tccggtgcag cagccgcagg gccgcgtacg cctcccggtc
     1561 ctccggcgcc gcatgggcgc ggcggagggc cttggggaac atgctggcgg cgacggtcac
     1621 cgggccgatg gccagaacgg cggcgatgac gtgcagggag aggaagaact tcgtcacgag
     1681 cggggccccg gaaccgtctc cgccgcccgg tcggtacgcc gtacgccgct gacccgcgag
     1741 gccgggagcc gcccggcccg ggaggtgccc gcgagggtgt cgccggtgac cgtgacgtcg
     1801 aaggcgaggt tcaggcgcat cggccgggtg accgcctgct tccaggtgag ccggtcgccg
     1861 gtgaggatga ggccgtcgag ggggacctcc tcgcccgcgc cccgggccga accggtcaac
     1921 gagccctcgt tgtcgtggag ttcgacgacc gccgcgatcc tgccgatggg ggtggagatg
     1981 gagaggtccc agatccctgt gacgggtcct gtggtggtca tgcgggtgct tcttccttcg
     2041 ttacgggggt gggtggggcg ggcccgcgaa ccggaggggg tccggggccc ggggttcaga
     2101 gcgcggccgg taccgggccc tgggcgcgcc agaccgtgcc gcgccgctcg tgggcgaaca
     2161 actcctcgat ggcgtgggcg atccgcggac cggcctcgcg ctccaggagg tgaagggcca
     2221 ggtcgagtcc ggaggtgacc ccagccccgg tgacgaggtc gccgtcgtcg acgacccggg
     2281 cgcggacggc gtgggcgccg gtggcgtcga ggaggtcgat ccccaggtgg tgcgtggtgg
     2341 cgtggcggcc ctccagcagc ccggccaggg ccaggaccag cgagccgccg cacaccgtcg
     2401 cgaccgtcac ggaggggtcg tccatggcgg cacgcaggag ggcgggcagg tcggtggcca
     2461 gggtgcggcc gaggaggacg gggacgggct ggtcgatcac ctcgccgggt gccgcggcgg
     2521 ccaccccgcc gtacgtcggc gcctcaccgg acacctcccc gtcctccggc tcacccaccc
     2581 gccccgaagc gcccggcacc agcaccagat ccgcccgctc cgggtcgagg gccgccgtgg
     2641 cgcgcagggt caggccgccg gcgccgctga ccacctcacg ggcgccctcg gcggagacca
     2701 gcttcacggt caccgcgcca ccggaggccg tgcccccggc gtgcagcact tcgaagggcg
     2761 cgaccacgtc gagggggtcg aagccgtcga acaggacgat ctgggcatgc atggcggggc
     2821 tcctacgagg gcggtggtcc cggtcgcagc aaccgggcac ggctccgacg ctatgcggct
     2881 gccgggcctc ctcccagcgg caggagtgcc agctttcaac ggaatatcgc cagggctcac
     2941 agcggcccca tcgtcgctga tcagaggcct gcccacaggc agaccgcacc ctccacccct
     3001 acagaaaccg ctcgccgggg aggtatcttc tcgccatgca caccgtcgcc gtcctcgcgc
     3061 tggaccaggt gatcccgttc gacctgtcca ccccgatcga ggtcttcacc cgcacccgtc
     3121 tcccggacgg ccggcccggc taccagatcc gtgtctgcgc cgagcggccg gaggtcgacg
     3181 cgggagcctt caccctgcgg gcgccctggg gactcgacgg gctcaccggc gctgacacga
     3241 tcatcgtgcc gggcaccgcc acccccacgg ccccgctctc ccccgccgtc cgcgacgcgc
     3301 tgctggccgc cgcccgggcc gggacgcgga tcgcctccat ctgctcgggc accttcccgc
     3361 tggccgccac cggcctcctg gacgggctgc gcgccaccac ccactggctg gcggccgacc
     3421 tgctggccgc cgcccacccg gagatcgagg tggacccgga cgtcctgtac gtcgacaacg
     3481 gcaggctcct cacctccgcc ggggccgccg ccgggctgga cctgtgcctg cacatgatcc
     3541 ggcgcgacta cggctcggcc gtcgccgccg acgcggcccg gctgtcggtg atgccgctgg
     3601 aacgggaggg cggccaggcg cagttcatcg tccacgacta cgcgcccgcc ccgcagggcc
     3661 acgccctgga acccctcctg gcctggctcc aggagaacct ggccaccgag ctgaccctcg
     3721 ccgacatcgc ggcccgcgcc gggatgagca cgcggaccct gatgcgccgc ttccgcgaac
     3781 agacgggcac caccccgctc cagtggctgc accgcgcccg catccgccag gcccagcacc
     3841 tgctggagac cacggaccac tccgtcgaac ggatcggctc ccaggtcggg ttcggctccc
     3901 ccaccgcctt ccgcgaccgc ttccgccgaa cgaccggcgt cagcccgcgc gcgtaccgcc
     3961 gcacgttcgc ctgaccccga cgcgaggccg gggccggggg gccgaagggc cgggccccag
     4021 gtgtaccgga ccagcggtac gagggctccg gttgcggatt ccccagccgc gtcggcgtga
     4081 ccgagaccga cggaaaagtg cagctcaacg tggaactcag cgaactcgtc caccgaccac
     4141 gcgcccgcac cccgcgctct atgctgcgag atacgacgcg agaccaggcc gaacgaggag
     4201 gcgccgggtg gcgacagggc gcaccgatcc cgaccggcgg gaccgcatca tcgacgcggc
     4261 actcgacctc atcgccgacg agggtgtggc gggcatgtcg caccggaagg tggccgcccg
     4321 tgccggggtt ccgctcgggt cgatgacgta ccacttcacc agcatggacg agctgctcca
     4381 cgaggcgttc acccggttct ccggcacgat cgtcgccgtc ttcgaggacc gcctcggtgc
     4441 cgccaccacc cccgacgagg cccgcgaggc cgtcgccgac ctggtccacc acctctccgg
     4501 cggcaaccag cgcgagctga tcctcactca cgagctgtac accctcgccg cccgcaagcc
     4561 cgcctaccgc gaactgaccc gcacctggat gagccgcagc cggcgcgccc tggagtggca
     4621 cttcgacccc gccaccgccc gccagctgga cgcgctcatc gaggggctct ccatccaccg
     4681 ggccctggag accgagccgc acgaccgcgc gctgacggtc gaggcgatcg cccggatcac
     4741 cactctgtga gcggacaagc caccgaaacg gccatggggt cgattgcgct gatcaggccc
     4801 ggaggacgcg agctcagcgg gacgatgaga cgtccacgta cgcgtccgac tcggaggccg
     4861 tcatgggcac gcacggcaag ccggcaccgg atccgtcgca gggcaggccg cccggcaact
     4921 cggacgggcc gaagtccccg gatcaccagg cccgggccgg tcacccaccg tctctgagga
     4981 ggtcgtccag ttcgtcggcg cagtccgtgc ggtcgcggga gaacgccacg atgccgccct
     5041 cccccttgct gccgctcctg gccgcgcgga tccggccctc gatctccgcg atgtacgcgc
     5101 ggcactcggc cttgatgtgt ctctcgggcc gcacctcggg tgcggcccga agccagacgg
     5161 tcgcggtcag gccggccacg cagagcaccg cccatgtgag gacccatgcg cggcggctca
     5221 tccgtcgtgg attcggcact ccggcagcct acgagcacga cggcggccgc gacgtcatct
     5281 tcacggagca gccgccagct cccgcgcccg caacgccagc cacaggtcgt agcgggcgct
     5341 cgggggcgga ggagcgagcg ccgcagcacg gtctccagcc gggtgaggcg cttgcgggcg
     5401 ccggggacgg agatccccag ctcggccgct gtcgggccga ggcggccctc gcagcgcagc
     5461 caggcccgca gggtctcctc ggccggtccg ccgaccgggg cggccagcgg ggccagttgg
     5521 cgggcggccc acccctggac ggcggggcgg cgcaggacct catcgagatc gagggcccgt
     5581 gccgccccgc cgtcgcgctg tccggaggac gctgtacgtt ccgtctctcc gggggccgtc
     5641 gtgcagaccg gggcgggggt ggaccggatc cggagggcca ggtcgagggc cgactggtcg
     5701 gccagccggc ggaggtccag gccgagcagt tcgccgatga gcctgaggcg ggcggccagg
     5761 gtgttgcggt ggaccttgag gtggtcggtc gcgtgcgacg agaacgccag ccaggacgcc
     5821 gccgttgccg ccagctcctg gcttcccggg tcctgcgccc ggcgcgggac atgcgtcagg
     5881 agcggggtca gcaggccctc ggcccactgc cgcccgacgt gcccgacgac gagggcgggc
     5941 tccggggcga ggtcgaaccg ggcgtgccgg gtggggagtt cacgggctac cgccagcgcg
     6001 tggaacgcct ggcggtagcc ggtggctgtg tcggcgagcg gcacgcgttc gctgacgccc
     6061 accacacagc cctccaccag ggcggcaacg gcctcgtcgg tggcggcccc ctggtccggg
     6121 ccgtcctccg ccggcatcac gaggatgagg tggcgcgcgt agacggggca ccgcacgatc
     6181 caggaccgcc cgccgtccgc acgggcgcag acccgggcca cctcgtcgcg ccggtccccg
     6241 gggcactcca cgacacccac ccgtacgggg tcggggagcc ggggccggag cgctccggcc
     6301 atctgctggg cgatggggag ctggcccgtc atcagcaggt gcagcaccgc ctcccggccg
     6361 cgcgactccg ccaggtccac ccggcgccgc ttgcgctcca ccgcctcggc ctcccagcac
     6421 agggagagcg gcatcagcgc atcggccagc agcgtggcga gcccggccgc caccgggcgg
     6481 ggcgtgacga cggcgagtac aggggcggcg gcgcggtcct cgccgtgcgg gtcgtacccg
     6541 ggcagcggga agagaaggag ggtgtgcgcc cccgtgtcgc gggagaacgc cagggccccg
     6601 cgctcggtca gcgcctgtac gccttcggcg acgagagcgg tcacgtcggg gatgccgaac
     6661 ccgtcggccc cgcccgcgcc accggtcgcc gaccccgttc ccccggacac cgttcccggc
     6721 ccaccgccgg acaccgttcc cgacgcgctc agcgacgtac cgtcggagga ggctattccg
     6781 gcccagccgt cggcgcggcc cgccagccag cgcagcagct ccgccgaccc gccgttcctc
     6841 gccagccgct gcatccgcag caggtcatca gcccgttgag gtgttcgcac atgatccccc
     6901 gatcatcact gtgcatcact gtgcggagtg ttacccccac ccgcgcccca ctgggcgcct
     6961 tgaacctccc cgtgccccta cccgccgatc tatggtccga acgtggtgtt ccggtaccgg
     7021 tcgcagcggc tcacgggggt ggtcgctgcc accgaggccg gggcatcccg ccacgggagc
     7081 gttgtcagtg gtggcctcta acgtcgtccg ggtccggacg acctgtgaga agaggcccca
     7141 gcgtggagtt ccgcatcgag tgcagtgccc tgaccgaagc cgtggcgtgg gccgcccgcg
     7201 tcctgccggt ccgctccccc gttcccgtac tgagcgggct gctgctggac accgagggcg
     7261 ggcggctgcg cgtgagcggt ctcgactacg aggcgtccgc gcgcatcgac gtggcggccg
     7321 ccgaggtggt gcgcccgggg aaggtgctcg tgatggggcg gcggctgctg gacatctgca
     7381 aggtgctgcc cgagggcccg gtggagtgcg ctgtggaggg gtcccggttc accgtctcgg
     7441 gggacggcgc ccgcttcggg ctctccgtgc tgccgctgga cgactacccc gcgctgccgg
     7501 cgctgccgca ggtgcggggt gcggtggagg cggaccggtt cgcggcggcg gtcgccgatg
     7561 tggcggtggc ggcggggcgg gacgacaccc tgcccacgct caccggaatc cggctgggcc
     7621 tcgacgggga gagcgggacg atgacgctcg cggcgaccga ccgttaccgc ttcgccgtgc
     7681 ggaccctccc gtggcaggcg gcggcggatg acgagagcgc cgatgtcgtc gtctccgccc
     7741 gccggttgac cgagatcgcc cgctcgctgg ggcggtccgg gctggtgagc gtcgcgctgg
     7801 acgccggttc ggcggggttc gagcacgcgg ggatgcggac caccgtgcgg ctgctggacg
     7861 ggcggctccc gcgccacgac aagctgttcg ccttggagag cccggccgtg gcggtggtgg
     7921 accggccgcg gctggtggag gccgtcaagc gggtctcggt ggtcgccgac ggggacggcc
     7981 cggtgcagat gacgttctcg gccgccgaca actccgtaca tctgcaagcc ggttacgagg
     8041 acgacgtggc gtcccagcgg ctgcccgcga cgctggacgg cgccccggag atgaccgtgg
     8101 cgttcaaccc ggggtatctc gcggacgccc tggcctcctt cgaggagccg acgctgcggc
     8161 tgctgatgat gggggcaggg cagcgggcga tgatcacggg tggggagggg tcgcaggccc
     8221 accggcacct gctgatgtcg gtgcggccgc cgctggtgta ggccggggcg ggccggactt
     8281 ccccgtacgg agtccggccc cgggacgccg aaacgggggg tccgcccggc ggtggccgga
     8341 cgcacccccc gtacgggtgg ggatcagacg atgggcatca agcggtgggg atcagcagct
     8401 caggttcgag ccggtggtgg tgccgaggat ctgggtgaac tgcgtgaact tgtcgatccg
     8461 gctctggacc tgcgccgggt tgccgccgtt gcactcgatg gcgccgttga tggagcggat
     8521 cgtctcaccg aagccggggc cgttgacgat ggcgttgtgc cccgtgatgg tgcccgggcc
     8581 ggtctgggtg ttccagtacc agaggccggt cttccaggcg atggaggcgt tctgctcgac
     8641 caggtagggg ttgttcagca ggtcgatgcc gagcgcgtca ccggcggcct tgtagttgaa
     8701 gttccagctg agctggatgg ggcccttgcc gtagtacgcg gactggccgg ccgggcagcc
     8761 gtagggctgg ccggcgtcgc agtagtgggg gtagttggcc tcgttgactt ccttgatgta
     8821 caccagcccg ccggtctcgt ggctgacgtt ggcgaggaag gccgccgcct cgcgcttctt
     8881 gatctcgtcg ctgccgctgt tggcgaaggc ggggtacgcg ctcagggcgt cggtgaggcc
     8941 ctggtaggtg tagaaggagt tccggttcgg gaacatctgg ttgaactgcg cctcgctgac
     9001 gacgaacccg ttgctctggc ccgggccgtc accgccgccg gtcccgcagg cgccgttgtc
     9061 ggcccagacg tcggaggagc cgggccgctc gttctgggtc caccacttgg cggtgtagtt
     9121 gcggccgttg agcgaggcgg tctggccgcc cgtgtagacg gcggaggagt tccaggcggc
     9181 gacgcaggtg gcggcctgtg cggtggcggc ggggaggacg acgaacgccg cgacgacagc
     9241 ggcgagcgcg accagcaggc cgagggcacg tttgatcacg tgaacacact cctaaggcgc
     9301 ggcgctacgt ccggccgtgc gccgccgtgg gggtgccgac actcaagcga tgatggtctg
     9361 gacctgtcaa ggtctagacc atcatccgtg aatatgccgc ccaccccgga gcggcccgcc
     9421 cccgcccgtg acaacgatgc catcagcgcc ctcaactgcc gtgattgcgg aaggagtcga
     9481 tccggatcac gccgtgagca gggcctggac gggaaggtaa aagatttcgg tgtgtccacc
     9541 atgcgggaca cacccgggcc ggccggtccg caggtttgaa agacgccgat cactcgttgg
     9601 tgagtttccc cggtaccggc acacaccccc ggcaaaactc gacagcacgg cacggacgga
     9661 ccgacggacg gcgccgaccg ggcccctgcg gttccggaca cactgcggct gggggatggc
     9721 gtggaacgag cgacggacac ccgcgagggc atcggcggac cgggcggaca ggcggtgctg
     9781 ctggcggcgg gcctcgcgga tctggccgtg accacggtgg gcgccgcctt cacctccgta
     9841 cgggggctgc tgcggcgctc cgacacggcc gagctggcgg ccggggccga gcaggacctg
     9901 atcgcgcgcg gccgcctcgc actcgaccgg tacgccacca cgcccccggc ccacctggag
     9961 gtgctggccc gccatgtgat cgcccagcgc gacggcgaac gtgtctgagg ggtgggagcc
    10021 cggcgccttc aaggcccggg tggaccaggt gctccaccgc ttcgcggccg gggaggccgg
    10081 gcaactcacg gcgatcgacg cctccttggg cccggtggcg gacgcggtgg agacggccgt
    10141 ggcggagggc aaaaggctgc gggcggcgtt ctgctactgg ggctggcgag cggccgggca
    10201 gcccgacagc gacgccctgg tgcgggcggc ggcctcgatg gagctcgtgc acgcggcggc
    10261 cgtggtccac gacgacctga tcgacgacag cccgctgcgg cacgggcgcc ccaccgccca
    10321 tctggccctg cgcgaggcgg tgcggggcca tcccgaaccc acgtcggcgg ctcgctcgtt
    10381 ggcgatgctc gccggggacc tgctgatgtc gatggccggg cagctcttcg tcaccagcgg
    10441 tctgcccgcc ggctatctcg gccgagcccg cccgctctgg gcctcactgg cccgggagtt
    10501 ggtggccggc gagtgcctgg agatcctgca caccggggcc gccgtgcccg atacggcgac
    10561 ctcgctcaag gtcgtccgct acaagaccgc caagtacacc gtggaacagc ccctgttgat
    10621 cggagcgctg ctgggcgggg cgggtgggcc gctgcgcgcg ggctgctcag cgtacgggct
    10681 gccgctgggc gaggcgttcc agctgcggga cgatctgctg ggcctgttcg gggaccccgc
    10741 gctcacgggg aaggacggct ccgacgacgt acgcggccat cggccgacgg ccctgctcgc
    10801 ggagacctgg cggctggccg gagaggagga ccgggcccgc ctgcgcaccc tgctcgcgcc
    10861 gggcaccgat acccgtacga ccggcaccgc cgacgccgtg cgcgacatca tgcgccgcct
    10921 gaaggccccc gaccggatcg agtccatgat caccgcccgg gccgaggagg cgctgcgcac
    10981 actcgacgag ctggacctgc ccgcccccgc cgtcaccgcg ctcaccgccc tggcgcactc
    11041 ggcggccgtc cgccgccact gacgcccggc cccaccacgc acccggcaga aaggcaaggc
    11101 cccgccatga cctccgcccc cgcctacacc caggcctcgt tggacgccct gcggcagagc
    11161 ggcgacgaac tcgccgacgc cacagtcgcc accctcttcg aacgcggcga ggtcggcacc
    11221 ttcaacaccc tgatgcggta cgtctccacc gccggtgccc cgctgcccga cggcctgccc
    11281 gacgtggccc gggattacct caacgccacc gccgcaccgc cgtcctgggt ggactggagc
    11341 gagatggaga aggcccggct cttcttcatc gacaacaacg tgcacatctc caccgccctc
    11401 tccttcgccg ccatgcccgc ctgttacgtc gtcccgcacg tggcgaagct gctgtcggcg
    11461 acgcacgggc tgaactaccc gtccaaacgg atggcggaga ccggccagtt caccgtccac
    11521 ctgatgcagc ccgacgcctt cgaggccggc agccgcttca tcccggccgc gcagaaggtc
    11581 cgcctcctgc acgcctccat ccgccaccac ctgcggcgcg agggcgcctg ggacacggag
    11641 ggcgcgggga tgccgatctg ccaggaggac atgatcggcg ggcagatgtt cttctcgatg
    11701 ctggtgctgg acagcctgca ccggctcggc atccatatgt ccgaggaggg cgcggacgcc
    11761 tactactacg catggcgggt ggtcggcgcg atgctgggcg tcgaccagaa ggccgtaccc
    11821 aagtccctcg ccgaggcacg ggagttcctg gacctctaca tgatccggca catgggtccg
    11881 tccccggagg gcgcgctgct gacccggcag ctcatcgacc tctacgagga ggtcgtcccc
    11941 ggcaccttct tcgacccgat cgtctccgcc ctcatccgcc acctcgtcgg cgacacctgc
    12001 gcggactggc tggaggtgcc ccgtacgccc tgggacaccg tcgccaaggc cgtcccgcac
    12061 ctgctcggcg tcctggagac catcgaggac cgctcccccc tcggcgcctg ggccctggac
    12121 cggatcggcc acctcaccac cgtcctggag ctgtcctccc tcacccgggg gcgcgtcatg
    12181 cactacgcga tccccgagca cctgaagaag gagtacggcg tcccgtccgg gcccgcccgc
    12241 accggccgct ggagcccccc ggcggcgacg gtgccgggac cccggtagga cccttcgccg
    12301 cgaggccgag cgaggagccc aactgctgcc tgaacaaagg gagaacaacg gccgtcactc
    12361 ctctcccgcc cctcccgctc cgcctacggt gactcgcacc gacgcgcggg cacgggggcc
    12421 gggcgcgcga gcacggggac cgggggggca gccgtggagt ggttcagcgc cgagaacgtg
    12481 gtggcggtgc tcaccgccgt actgggcgtc ctcgcctcga tcggcgtgct ctggtacgag
    12541 cgccgggtgc cccgccgcaa acgcgtcggc taccgcgtcc agatggacac gcccatcggc
    12601 agcgatgtga gccagggccg ggccaacgta cgcctcggtc tcttcagcga gacccccgac
    12661 atgtcggacg ccacgctcgt cctgctgcgc gtcgagaacg acggctcgca gtccatcgtc
    12721 gacagcgact acaccgggcg cgaactgcat ggactgaccg ccgagttcac cgggcgcacg
    12781 gtacgcggca tagcggtcac ccagcccccc ggcgccgtgc acctgatgga gcacttcacc
    12841 ccggccgccg gggtgcggca caccggctcg ctgatccggc tgccccgcgt cccgctgaac
    12901 cggggcgagc acttcaaact gctggtgctg ctgaccggcg gggacgtcgg cagcccgatc
    12961 cggatcaccg gcggcatccg ggacggtgag gtgatggtca accgcgccgc ccgccccgac
    13021 gacaaaccgc cgctgttcgg ccgggccgcc cggctcatca ccgtgaccct gaccgtctgc
    13081 gtcgtggtcc tcgccgcgat catcctggtc cgggacgaca ccccgccgcc gctggactgc
    13141 gcacgcggcc aactgcgggt caccggatcg accgccttcg cccccgtcgt acgcgagctg
    13201 gccacgacgt acatgaagga gtgcgagggc tcccgcatcg aggtggaccc gcacggcagc
    13261 aactccggca tccgcgaact ctcggacgag ggcgcgcggt ccgcgaaggg cggctctccg
    13321 gcgctggtgg ccctctcgga cggcccgaaa ccgccgggcc acccggagct gcgcgagacc
    13381 cgcgtcgccg tgtcgctgtt ctccctggtc gtcaacgacc gggtgccggt gcgcgacctg
    13441 gcgctggccg acatccgccg catctacgcg ggcgagatcc gcaactggcg ggagctgggc
    13501 ggcccggacc tggagatcct gctcgtcagc cgggacgcca actccggcac ccgcgaggtg
    13561 ttccagcgcc gggtgctgga ccgcaacgag cccgcccagt cctcccgcga ctgcgccacc
    13621 aaggacgacc cgcgggcccc ggtcgtccgc tgcgaactcg acggcaccga ccaggtcctg
    13681 gccaccgtcg cccggctgga cggcgccctc ggctacagcg aactgcgcgc cggcagcgag
    13741 ccgcgcggcc tgcaccggat ctcgatcgac ggcgcccacc cgtccgtcga cacgatcggc
    13801 accagcccct acccgtaccg ggagatcgag tacgcctaca cctacggccg cccgcccgcc
    13861 gactccctcg cctccagctt cctcggctat ctgagccggg ggcgcggcca ggacgtcatc
    13921 cacatccacg gccacctgcc gtgcgcgacc ccgaagggtc tgcgggtctg cggcgaggac
    13981 tgagcggagt gtcggcctgc gcctacgcgg aagggccccg gaccgatgag ggtccggggc
    14041 ccttcgcgta ccgctccgta ccgcctacag gaacgagttg atctggatcg tctcggtccg
    14101 gccggggccg acgccgatcg cggagatcgg ggcgcccgac atctcctcca gcgccttcac
    14161 gtacgccttg gcgttcttcg gcaggtcgtc gaaggtcttg gccttggtga tgtcctcgga
    14221 ccagcccggc aggttctcgt agatcggctt cgcgtggtgg aagtcggtct ggttgtacgg
    14281 gagctcctcg acgcgcttgc cgtcgatctc gtacgccacg cagaccggga tctgctccca
    14341 gccggtgagc acgtccagct tggtgaggaa gaagtcggtc aggccgttga cccgggtcgc
    14401 gtaccgcgcg atcggggcgt cgaaccagcc gcagcggcgg tcacggccgg tggtgacacc
    14461 gcgctcgcca ccgatgcgcc gcagcgcctc gccgtcctcg tcgtgcagct ccgtcgggaa
    14521 cggaccggcg ccgacacgcg tcgtataggc cttgaggatg ccgatgacgc ggctgatctt
    14581 cgtcggcccg acaccggccc cggtgcaggc gccgcccgcc gtcgggttcg acgaggtgac
    14641 gaagggatac gtgccgtggt cgacgtcgag gagcgtgccc tggccaccct cgaagaggac
    14701 gaccttgccc tcgtcgatgg catcgttcag gatcagggtc gtgtcggcga cgaacggctt
    14761 gatctgctcc gcgtactgga gcatgtcctc gacgaccttg ccggcctcga tggcccggcg
    14821 gttgaagacc ttggccagga gctggttctt ctgctccagg gccgcctcca ccttctgctc
    14881 caggatcgac tcgtcgtaga ggtcctggac gcggatcccc acccggttga tcttgtcggc
    14941 gtacgtcggg ccgatgcccc ggcccgtcgt accgatcttg cgcttcccga ggaagcgctc
    15001 gctgaccttg tcgaccgtga cgttgtacgg agtgatcaaa tgagcgttgc cgctgatcag
    15061 aagcttggac gtgtcgacgc ctcgctcgtt cagaccgctc agctcggaga gcaggaccgc
    15121 cgggtcgacc acgacaccgt tcccgatgac cggggtacag cccggcgaca ggattccgga
    15181 ggggaggaga tgcagtgcgt acttctggtc gcccacgacg accgtgtgac cggcgttgtt
    15241 accgccctgg tatcgcacga catagtccac ggatccaccg aggagatcgg tggccttccc
    15301 cttgccctcg tcaccccact gagcaccgag cagcacaagt gcgggcacag gcgtacaccc
    15361 cttccgggcg gggcatgtcc aaggtcaggg ggcgtacgta aaggtcgtac ctgccgcacg
    15421 acgatgtacg gcaaagcctg agccgtcgaa ccgggtgccc cggaatagac gaagcccctg
    15481 gcgcaatagc gcaaggggct cttgcaccaa gatgctaccc gaggaaggac ccaggtgtcg
    15541 gctgcagagc cccccggcga cggcggcgac cagcttctgg tggtcatcga cccggtcgcc
    15601 cgccggaccg acggcgagtc cgtccggatc gcgaaggacg tgctgagcgc cggttcgcac
    15661 gccaagatct gccttccgga caccccggag gagttcgccc gggccctgtc ccggcggggt
    15721 gcgcgccgcc cggtggtggt cggcgacgat cacgcgctgc tgcgtgccgt ggcccagctc
    15781 caccgggagc gcgagctcgc cgcgggcgtc ctctccctga tccccgtggg cgccgcgcac
    15841 gccctggagg tggcccatgc gctcggggtg ccccggggcg cggtggcggc cgcgcggaca
    15901 gcgctggacg gggcggtgcg gcggctggac ctgctggtgg acgacagcga cggcgtggtc
    15961 ctcggccggc tgcgcatccc cgcccccacc ctgctcgccg acgccccgca cacgggggtc
    16021 accgccgtct gggacacctg ccgctccctg atgacgtccc tggtccgccc cgcggccccc
    16081 ggcggagcca ccgcgccccc ggggacgcac cggctgcggg tcgaggcgga cggggtgctg
    16141 ctgagcgacc tggacgcgcc ggtgcggggc gtctcggtgc tctcccaggg cgacgggggc
    16201 ctggccgacg tggtggtccg cacctcggac ggcgaggacg tcacggtgga ggccaaggcc
    16261 gtcaccgtct ccggcgcgga cttccgctac cgggccgaca tacagaccgg gggcccggtc
    16321 cggacccgga cgtggacggt gcgggcgggt gcctgggggc tgatgctgcc ggtgcccgcg
    16381 agctgatccc gcccggtccc ggcggccccc gcgagcgcgg acggggctgc gggaggggta
    16441 gcggggtacg cgcccacggc tgcgccggcc gccaccctcg gacgaggacc agcagcgggt
    16501 gggcgaggag atcgcgggcg tggcacgcga agagccgggg ccccgaacca gcccctccgg
    16561 cgttcgcgga gcgggagtcc gggggcgctg ccccctgggg ccggcaccgc aggaccgcgg
    16621 cccaccctgc cggaccccta cacctccacc accagctccg tcagcccccg gatcacgaac
    16681 cccggctgcc actccggctc cgccaccagc cgcatcgcgg gcgccttccg cagcaactcc
    16741 ccgaaggacg cctccagttc gagccgggca agcggcgccc ccaggcagta gtggatgccc
    16801 gcaccgaacg tgacatgcgg gttgtcggcc cgggtcagat ccagcctctc cggctccgcg
    16861 aaccgctccg gatcccggtt ggccgagccg aacagcagcg ccacctccgc cccgcgcccg
    16921 atcagctgcc cgtcgacctc gatgtcgtcc agcacccacc gctcgaagag ctgcaacggg
    16981 gtgtcgtagc gcaggagttc ctccacagcc gtcggcagcg acgcgggcgc ggcccgcagg
    17041 gcggcgagct gctcggggtg gtggaagagg gtccgccacc cgttgaccgt ggtgttcacc
    17101 gtcgcctcgt ggcccgcgtt cagcagcagc acacacgtgg agaccatctc ctgcccggtc
    17161 agccgctccc cgtcgtcgtg ggcggcgatg agcgccgaga tcaggtcgtc gccggggtcg
    17221 gtgcgccgct cggcgatgag cccgcgcaga tacgcggaga actcctccga cgcccgcacg
    17281 gccgccttcg ccgtctcctc cgacgggttc agctcgaaca tcccgcagat cgccgccgac
    17341 cagggccgca gcggcccccg gtcctcctcc ggcaccccca gcatctccgc gatcacggcg
    17401 acgggcagcg gttcggccac ctccgccagc aggtcgccgc cgccctcggc cacgaacgcg
    17461 tcgaccagcc cggccgccag ccgccgtacg gtcggagcga ggttctcgac cgtacgcggg
    17521 gtgaaggcct tggagacgag ccgccggatg cggggtggtc gggcgcctcc aggtccagca
    17581 gcccctgccc gttgagcgtg gtgaacggct cgtgcgcggc gggcggcggg gtgcggccga
    17641 actcctcgtg ggtgaagcgg tgcagatacg tacggcccag gcggcggtcg cgcagcaggg
    17701 ccgacacgtc ggagtggtgc gggatcagcc actgcccggt cggctcgaac cagtgcgcgc
    17761 gaccggcggc gcgcagggcg gcgtaggcgg ggtagggatc ggcgacgaac gcgggcgacc
    17821 agggatcgaa ggacacgtgc atgacccgac gctacccgcg cccgccgcca ccgcaagggg
    17881 cacgcaccca tccctctcgc caccgcaagg gacccgggag ccccggccac cgagcgaccc
    17941 ccgcccgggc aggaggcccg cacacatccg ccgcgctacc ccggtgtgac cagccgcgcc
    18001 tcgtacgcga acaccgccgc ctgcgtccgg tcgcgcagcc ccagcttcac caggatgcgg
    18061 ctgacatgcg tcttgatcgt ggactcggcg acgatcagat gcgaggcgat ctccgcgttg
    18121 gacagcccct gggcgatcag gacgagcacc tccgtctcgc gctcggtgag gtccccgacc
    18181 cgggcgagcg cgggcggtct cggggcctcc gcgagcttgg agaactcggt gatcagccgc
    18241 cgggtcacgg tcggcgcgag cagcgcctcg cccgaggcca ccacccgtac accgtccgcg
    18301 agctgccggg ccgaggcgtc cttgaggagg aagcccgagg ccccggcccg cagcgcctgg
    18361 tacacgtact cgtccaggtc gaaggtggtc aggaccagca ccttggcgtc cacgacctgc
    18421 gcgacgatct cgcgggtggc gtcgatgccg ttcatccccg gcatccggat gtccatcagg
    18481 acgacgtccg ggaagagggc cgtgaccttg tcgatggctt cccggccgtc caccgcctcc
    18541 cccacgacgg tgatccccgg catggcgttg agcaggacgg agaagccctc gcggaccatc
    18601 atctggtcgt ccacgatcag gacgcggatg tcgctcatgc cccgtccgcc ttcttgtacg
    18661 gcaggaggtc ggcggccggc gcgtccggct caccctccgc cggcggtacg ggcaggaaca
    18721 ccgcgacctc gtacccgccg tcctccgtcg tcgccgccgt catctcgccg ttcagcatcg
    18781 ccacccgctc ccgcatcccg gtgatcccgt gcccggcccc cggcgacggc ttcaccagcc
    18841 ccctcggagg cccgttgacg atccgcagcc cgagcccgcc gagtacgtag gcgatctcga
    18901 cccgtgcggt ggcgccgggc gcgtgccgca gggtgttgct cagggcctcc tggatgatcc
    18961 ggtacgccga cagctccacg ccctggggca gctcgcggac ggccccggtg accaccttct
    19021 ccgtctccag gccggtctcg cggacgttgt ccaggagccc gtcgaggacg gcgagggtcg
    19081 gctgcggggc gtccggggcc tcgtagtcct ccgcccgtac gacaccgagg acgcggcgca
    19141 gctcggtgag cgcggccacc gcgttctccc ggatggtgac gaaggcctgc tccagctccg
    19201 gcggcgggtt ctccacccgg tagggggcgg cctccgcctg gatcgcgacg accgacatgt
    19261 ggtgggcgac cacgtcgtgc agctcgcggg cgatggtggt gcgctcctcc agcagcgtgc
    19321 gccggtcgcg ctccacggcg gtgacggtgc gctgcacggt gacctcacgc tcggcctcgc
    19381 ggacctcctg cgcggcgtcg cgccggacct ggagcatggc gacgacgagc agcgcgaagg
    19441 cggagaggac ggccatgggc gcggtgatcg acgggtcccc gccctccagc agcagcccga
    19501 acagcagggt catcagccac atccaggccc ccgtgcgcgg ccgggtcctg gccgccacga
    19561 ccaccatgac caccacctgc gcgatgaagg cgctgggccc ccacagcccg tcgctgccca
    19621 ggaccgcaca gaagaccgcc gcgagcatcg acccccagaa cgcggcgacc ggcctgacca
    19681 gggtcatcgc gaccgcgatc gcgggcacga ggcccatgag gaaccggaag tgccagttgg
    19741 cgagccccgc caacagcacg atcagggcgg cgcccagcac cagggcgtgc ggggtccaga
    19801 cgacgagccg ccgcaccccc tcgggcagcc ggcgtatgaa ccggccctcc ggcgagaggg
    19861 gcggcagcgg gcggtaggcg aacacatggc ggaagaggtc ttcccggagg ccttccatcg
    19921 cgccttcggc tgcccggagc tccgggctac tggtcttcgt ctgggtctcg gtcacgttta
    19981 cacggtaggc gggggcggag tgcgggtcgt ccctaccggt gcggattccg gggcatccct
    20041 ctcaaggact acggggcctg cccgcgcctc gtggcggcgc cccccgaccg ccgccacggg
    20101 gccctcacca gctcgcggac ggaagaattc cgtccggctc acgaccggaa gaattccgcg
    20161 tgctccccgg cccaccgcgc gaacgtccgg gccggccggc cggtgacctt ctcgacggtg
    20221 tcgatcacgg ccctcccctc cggcgggatg tccccgcccc cgttgaggac ggtcacccgg
    20281 cgcacccccg ccgcgcgggc ccgctccatg atctcctcgc cggtcgtcag cggggcggag
    20341 aggccgccgt cgaaggtgat caggtgcagc ccggcgactc cctccagcgc gctctccagc
    20401 gaggccgggt cggcgaggtc gccgcggacg acgtcgaccc ccgcggggaa ctccgcgcgt
    20461 gccgggtcac gggtcacggc ccggacgtgc tcgccgcgct ccaggagctg ttcgaccact
    20521 cgaaggccga ccgttcccgt ggctccggtc accaggatcg tcattgcggg tctccttcgt
    20581 tcggttcggc atcgaccaac gtggggaccc tcgcggtcag ctactgtccg cgacgaaggg
    20641 ggctgcgggg aagctcacca agccagctgc gtgatctcct ccgccacgat cgcgcacgcg
    20701 tcggccgccg ggtcgatcag cgggaagtgt ccgacgtccc cgagcagcgt gagcccgacc
    20761 atctcgccgg acttcgccgc cgcgtcgacg tacgcctccg agacggccag cgggacgacg
    20821 gtgtcctcct cgccgtggac gatggcggtg gcgatcccgg tgggcagcag ggcggcgggg
    20881 tcggcctggg ccgtacgatc cgccgactcc acgcccgctc ccaggagttg ggtgatcgca
    20941 ccaccgcaca cccccagctc caccgatgtc gcgaagtccg cgatcggggc gagcgcgacc
    21001 accccgcgca acgggggcgg ggcgggcagg tgccacggcg acccctcggg cagcacgtgg
    21061 cg
//
