LOCUS       NZ_CP032543            31111 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2347231
            Orig. end                         :: 2378342
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..31111
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /product="lanthipeptide-class-iii"
                     /region_number="9"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..31111
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..23147
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23147
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13147](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13147
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    350..364
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
     misc_feature    complement(383..401)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    complement(583..594)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(847..863)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(875..889)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    1119..1132
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            complement(1760..2026)
                     /locus_tag="D6270_RS10775"
     CDS             complement(1760..2026)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969066.1"
                     /locus_tag="D6270_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109165610.1"
                     /transl_table=11
                     /translation="MAFIKRVALAPRAVRQLRRVRSVYAVGMALSLLGLVLQMERDPGG
                     RQTHLAAVLLVAFTALLGLTAVQLWRHTRTRHCSTAKKLTRAA"
     CDS             2025..2153
                     /gene="allorf_2349256_2349384"
                     /locus_tag="allorf_2349256_2349384"
                     /protein_id="allorf_2349256_2349384"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCAGYPRDAEPVTAVGAVRWRACRRRGSRSGAGGRHTPERRR"
     CDS_motif       2025..2075
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCAGYPRDAEPVTAVGA"
                     /locus_tag="allorf_2349256_2349384_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2076..2153
                     /prepeptide="core"
                     /locus_tag="allorf_2349256_2349384_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.10"
                     /molecular_weight="2923.3"
                     /monoisotopic_mass="2921.6"
                     /core_sequence="VRWRACRRRGSRSGAGGRHTPERRR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCAGYPRDAEPVTAVGA"
                     /leader_location="[2024:2075](+)"
                     /alternative_weights="2941.3"
                     /alternative_weights="2959.3"
     gene            complement(2225..2965)
                     /locus_tag="D6270_RS10780"
     CDS             complement(2225..2965)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891398.1"
                     /locus_tag="D6270_RS10780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_109165609.1"
                     /transl_table=11
                     /translation="MTSSELWTRETADRYDTEEAENSSPAVLGPALDFLAELAGDGRAL
                     EFAIGTGRVGIPLRERGVPVVGIELSEHMVAALRRKIDESALPVTIGDMATTTVPGTFT
                     LVYLVYNTISNLLTQDEQVECFRNAARHLEPGGRFVIELGVPPLRSLPPGRTAVPFDVS
                     ERHLGFDTFDLVEQILVSHHLTRDGDDGRYRRSNSRHRYAWPAELDLMAKIAGLGPERR
                     VADWDGTPFTQDSPRHISVWRKPA"
     gene            complement(3106..3612)
                     /locus_tag="D6270_RS10785"
     CDS             complement(3106..3612)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019764883.1"
                     /locus_tag="D6270_RS10785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TspO/MBR family protein"
                     /protein_id="WP_109165608.1"
                     /transl_table=11
                     /translation="MPPTRTTSTAATPSRHRGWLTLLLFLALCYGVAAAGAIATGDAGS
                     TYAALDRPAWAPPGWLFGPVWTVLYGMIAVAGWLVSRRPGPGRRPALVAWGVQLALNAL
                     WTPLFFAAEQYGLAFLDIALLLAAVVTTVLLSARVDRRAAWLLVPYLLWVGYASALNLA
                     LWLAN"
     CDS             3661..3840
                     /gene="allorf_2350892_2351071"
                     /locus_tag="allorf_2350892_2351071"
                     /protein_id="allorf_2350892_2351071"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MFPFPASRFPISASRFPLPRAFLGRCRERMLLKGSEIRWPGRRPR
                     CYGARASTAVPDRR"
     CDS_motif       3661..3765
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MFPFPASRFPISASRFPLPRAFLGRCRERMLLKGS"
                     /locus_tag="allorf_2350892_2351071_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3766..3840
                     /prepeptide="core"
                     /locus_tag="allorf_2350892_2351071_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.10"
                     /molecular_weight="2791.2"
                     /monoisotopic_mass="2789.5"
                     /core_sequence="EIRWPGRRPRCYGARASTAVPDRR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFPFPASRFPISASRFPLPRAFLGRCRERMLLKGS"
                     /leader_location="[3660:3765](+)"
                     /alternative_weights="2809.2"
     CDS             3876..3980
                     /gene="allorf_2351107_2351211"
                     /locus_tag="allorf_2351107_2351211"
                     /protein_id="allorf_2351107_2351211"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPRPVVPSLPRRACGAGATGPDRVRSRRRTSTVC"
     CDS_motif       3876..3929
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPRPVVPSLPRRACGAGA"
                     /locus_tag="allorf_2351107_2351211_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3930..3980
                     /prepeptide="core"
                     /locus_tag="allorf_2351107_2351211_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="1757.0"
                     /monoisotopic_mass="1756.0"
                     /core_sequence="TGPDRVRSRRRTSTVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPRPVVPSLPRRACGAGA"
                     /leader_location="[3875:3929](+)"
                     /alternative_weights="1775.0"
                     /alternative_weights="1793.0"
                     /alternative_weights="1811.0"
                     /alternative_weights="1829.0"
     gene            4131..4490
                     /locus_tag="D6270_RS10790"
     CDS             4131..4490
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944269.1"
                     /locus_tag="D6270_RS10790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_109167501.1"
                     /transl_table=11
                     /translation="MSSPMSVSSLDTFTCVRCGLTVAASAPDGGRRNHCPSCLHSRHLV
                     DQVEGGPSDCEGRMTPISIAVLRTGDWMVVHRCVRCDELTSNPVCGDDNQLILMRMAVR
                     PLAQPPFPLEAFGDL"
     gene            4487..4906
                     /locus_tag="D6270_RS10795"
     CDS             4487..4906
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056536.1"
                     /locus_tag="D6270_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_109165607.1"
                     /transl_table=11
                     /translation="MTRRRARPAGRRRPQRAKDVLHGPAGARGDAFRCVGCRLDVSLVA
                     PGTAHRNHCPSCLVSLHVDRRVPGDRAAGCGGRMTALSLSVRADGEWMLIHLCLTCGEL
                     SANRIAGDDNPLALIRLALRPLADAGIPARVMLAL"
     gene            complement(5179..6015)
                     /locus_tag="D6270_RS10800"
     CDS             complement(5179..6015)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552741.1"
                     /locus_tag="D6270_RS10800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_109165606.1"
                     /transl_table=11
                     /translation="MNDEHLSRLSLNQETIKQWSLPELAEGCAKAGIGKVGLWRAPVQA
                     YGVERTARLIADAGLSVTSLCRGGFFTALDPEERARALDDNRRAVDEAAALSTDTLVLV
                     SGGLPPGSRDLYGARERVADALAELAPYAAERGVRLAIEPLHPMFASDRCVVSTLGQAL
                     DIAERFPAEQVGVVVDTYHVWWDDRAPAEIARAGAAGRIHSFQLADWITPLPAGVLLGR
                     GQLGDGSVDFRAFRREVEAAGFDGPIEVEIFNEALWARDGADVLAEVAERYGQHAC"
     gene            complement(6012..7166)
                     /locus_tag="D6270_RS10805"
     CDS             complement(6012..7166)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124633.1"
                     /locus_tag="D6270_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_109165605.1"
                     /transl_table=11
                     /translation="MTAPVPLPQGPYTPRTTPLALAPGGAPLTSRTVFSAAHVVADPYA
                     DISPDDPAAVDWESTLAFRRHLWSHGLGVAEAMDTAQRGMGLDWAGAAELIRRSAAEAK
                     AVGGRIACGVGTDQLPASGEPALAEVRSAYEEQLALAEENGVQPILMASRALARAARGP
                     EDYLSTYAHLLRQASEPVILHWLGPMFDPALDGYWGSTDLDEATDTFLKVIAEHPDKVD
                     GIKISLLDAAREIDVRRRLPGGVRCYTGDDFNYPELIAGDEQGFSHALLGIFDPLGPLA
                     AHAVRVLDTGDVAGFRALLDPTVGLSRHLFQPPTRFYKTGVVLLAWLAGHQDHFTMVGG
                     AQSARSLPHLAKAYELADGLGLFPDPELAAHRMRALLAVNGGTR"
     gene            complement(7163..8314)
                     /locus_tag="D6270_RS10810"
     CDS             complement(7163..8314)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317389.1"
                     /locus_tag="D6270_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_109165604.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.9e-09, bitscore:
                     36.2, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1e-25, bitscore:
                     88.6, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRTVRIAMNGVTGRMGYRQHLVRSILAIREQGGLDLGDGEVLW
                     PEPVLVGRRAHALEELAARHGLTEWSTDLDAVLADDTVDIYFDAQVTSARVEAIKKAVA
                     AGKHIYTEKPTATDVEGALDLARLARDAGIKHGVVQDKIFLPGLLKLKRLIDGGFFGEI
                     LSIRGEFGYWVFEGDWQEAQRPSWNYRAEDGGGIVVDMFPHWEYVLHELFGQVTSVTAH
                     VQTHVPRRWDEHGKPYEATADDAAYGIFQLAGGAVAQINSSWTVRVNRDELVEFQVDGT
                     HGSAVAGLRNCRVQHRSSTPKPVWNPDLPVTESFRDQWQEIPDNQEFDNGFKAQWELFL
                     RHVALDEPYTWDLLAGARGVQLAELGLKSSAEGRRFEVPELTL"
     misc_feature    8338..8349
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     misc_feature    8417..8428
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.95"
                     /tool="antismash"
     gene            8424..9500
                     /locus_tag="D6270_RS10815"
     CDS             8424..9500
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608629.1"
                     /locus_tag="D6270_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_109165603.1"
                     /transl_table=11
                     /translation="MTVTLADVAARARVSPATVSRVLNGNYPVAASTRERVLRAVDDLD
                     YVLNGPASSLAAATSDLVGILVNDIADPFFGIMAGAAQTQIGGPGDGSGRAGGEKLAVI
                     CNTGGSPERELTYLTLLQRQRAAAVVLTGGAVESPDHQAAMSVKLAKMADAGTRIVFCG
                     RPPLPDGDALVAALAFDNRGGGRRLTEHLISLGHRRIGYVAGPPERTTTRHRLEGHREA
                     LRGAGLDTVPEDEERLTVHGPYDRRSGYEATLEILRREPGVTAIVAANDTVALGACAAV
                     RDQGLRIPQDISVAGFDDLPFSVDAVPALTTVRLPLFEAGARAGRLAMGKENPPPGGIA
                     TIAAELMIRGSTAPPRVG"
     cand_cluster    8481..31111
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    8481..31111
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[18480:21111](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(18481..21111)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="2"
     gene            9692..9874
                     /locus_tag="D6270_RS10820"
     CDS             9692..9874
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D6270_RS10820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158650499.1"
                     /transl_table=11
                     /translation="MAFAEVATCPALARVCVTLAARGEALARVFGPGGLSYGRDLRRRV
                     GRGRAVPGPLNQAGH"
     gene            10001..13147
                     /locus_tag="D6270_RS10825"
     CDS             10001..13147
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608630.1"
                     /locus_tag="D6270_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_109165601.1"
                     /sec_met_domain="DUF4135 (E-value: 2.4e-104, bitscore:
                     348.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-22, bitscore: 78.9,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKELIGSGGTGAAARPALPGTNGSVVSARSAAAGSLASSPSAAA
                     AVTAAEAARTNHLPTNAASKPNATGAGTGAGSTTPGTGPWWLPGVVGEPPLCEPDWVAF
                     VRAVIADAPPRAVVAERDYPGLTGFALVVAPFAERAAGRLLTSPSNNAVRAGNAVGLAP
                     VLEDFRSHLVRRLARLAARTLVLELHKARRAGRLAGEAPEERFRDFLRRTAGRDGLAAF
                     LTSYPVLARILARTSLAAADAFTEMLGRLADDRELLAASGVLGDRGAEGAGRGPVALTG
                     VEAGAGDSHRGGRSVMLLRFTDGTRLVYKPRPLAAHRHFNSLVEWFGSLPGTPGLRALR
                     VLDRGDYGWVEFVEERPCTSTAETHLFYRRQGALLALLHLLDGTDLHQENLIACGSHPV
                     LVDVETLFHPPLTQAHSADPAARALHDSVHRVGLLPQLLVGDSAALDVSAIGGGRAASS
                     PIETADWADAGTDTMRLVRRSARFTESANRPRLDGVPADPSAYTDSLCEGFRVGYTAIS
                     DYRDELLGKRGLLTDFAGDEVRVVPRPTWAYTTLLDESTHPDLMRDATERDQVLSLLRT
                     PALGVPALPGLEDEEIEELWNGDVPVFLTRPGSSDLWSGTGRGVPVAPGPTGLARVEEK
                     VRAMDSVDRQDQERIIRAAMVSTSPEPPHRAEDGTRARTAATAPEPEQLLSAARSVGDQ
                     LVSLAYRHETRTNWIGLELLGERYWRLAPMAADLAGGYTGPALFLAQLAALSGAERYAE
                     AAREALAPVPGLLDALHGRVDDLAVLGSGAFAGLGGIAYALAEVGSLLDDLTVLELAGP
                     ATRLACAAGAAENGYGVRGGAAGGLVSLLAVHRTTGRAEAWRGAERCAERLAVAPLPAS
                     GGFAEGAAGIGWALLRFSAAGGGEQYRTAGLRALRRATVEVTGGRAWCEGAAGVALAVA
                     DSPDALADPDLSGWLAERAGELADCAPLADDSLCHGELGLLELLGHPALTGDRAPWVRR
                     AGTLLAAADREGPRCGTPGHVPHPGLLTGLSGIGHGLLRAGFPDRIGSALLLHPSAGVA
                     "
     misc_feature    13234..13247
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.11"
                     /tool="antismash"
     gene            13297..13491
                     /locus_tag="D6270_RS10830"
     CDS             13297..13491
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608631.1"
                     /locus_tag="D6270_RS10830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109165600.1"
                     /transl_table=11
                     /translation="MTHISESAMQGSGTSAHEGAYDHPAGQISLGIGGGLGMRSRLLSA
                     SEGEAGNTIDLPWTTMIPL"
     gene            13564..16479
                     /locus_tag="D6270_RS10835"
     CDS             13564..16479
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124639.1"
                     /locus_tag="D6270_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_109165599.1"
                     /transl_table=11
                     /translation="MRATSPVIVGRDEEIGLLSSALDAVQRRSGRALFFLGEAGIGKSR
                     LVGECAYRAYGLNMPVLRGRATSTGLVVPFRPLVEALSSRFRAAGTPTDPELAPYHPAL
                     ARLVPEWRQEASPGYPETVVELAEALLRLLSVLGRESGCAILLEDLHDSDTETVAVVEY
                     VIDNLADLPILLLGTLRPEPGAALDLVRSAERRQAATVKELKPLAEDQMRALTGACLEA
                     APEEIPPVVHQRLAERAGGNPYLVEVLLADLLDTDQLRRADGGWEAADDPGGPVPSGIV
                     RSWTRRLDRLDEPVRELLLAAATLGGQFSVSVLQTVTGFEDRALFTHLRSAVEAGVIAP
                     DGAAPDRYAFRHSLTAEALISSLAPAERASLARRAAVAVEHSGHPLDEDGQQLVASLHL
                     AAGNRSGAALRFAEAGRRMLASGAHGSAVVLLERACPLAADADRAAIAESLAVARAEGG
                     DLDAALELAETLPPVPARTEAADRRGEVHVKIAWVAVMAERAADAARQIDAARTLLGHE
                     PAPGRRAALAVADAHLALLPGQEHRCPSETERAAREAAEIAEAEGLPVVACQAWQLLAL
                     LLREKGFDEADACLERMLALSTDHDLPVWRVEALVRLGANAFMRTGDASRLRSARAAAT
                     ELGALLLTQTVDGLLAMNTVLCARWDEAQEIIDRSLEASARVGNLSAHRYLLLSAATMA
                     AHRGRRRDMDRALAAFRRAGGEQSLLVPHQLGLCKAIGALLEEDRGRALEGLDAVQAWE
                     RDHPSYFYLSGSYGLRPFLRVLAGAADREEYEAVRASPGAGLAWNGQFLELADAVLLGR
                     SGDRAGAARLVDAFDTRSTPFPVARHLGLRLVADAAQADGWGEPVAWLRRAEEFFYGVG
                     AQVVASACRAALRQAGASVTQHRGGWDRIPLSLRTSGVTPREYEVFVLLPERPGNQQIA
                     RRLSISPRTVEKHMASLLSKTGRADRSALCEFAAECAVEPA"
     misc_feature    14458..14460
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16496..16510
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            16644..18494
                     /locus_tag="D6270_RS10840"
     CDS             16644..18494
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969054.1"
                     /locus_tag="D6270_RS10840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_109165598.1"
                     /transl_table=11
                     /translation="MIRPPARPAPGAVYFSLLGPLTAVRDGRPLPLGPRKQRLVLATLL
                     ARPNTPVPVDVLTDAVWPDDPPRTARKNLQVYVSAARALLGGDGRDRVVHGCGGYRLTI
                     DEGELDTLRFRSLARAGRAAGERGDLRSAARLLREALDLWEGPPLNDLRDSTGVAEEAE
                     RLEARCLTVYEDWAETEIELGRAGVAVDGLRDLVERHPLRERLRVAWMNSLHQSGRQAE
                     ALAVYDDYRQLLARELGLEPSPAMAALYRAMLGRGRTARPQAAGRDTAHGTALPAAPRH
                     FTGRREELRELLTLLGSPDERVVVVSGPAGSGKSALALRAAHLLGDGFPDGRFHVRVRR
                     EDGSARTPAEVLGELGRSCGVRVPTVPAVPAGPESGPAAVSQGAEDAWQLWLSLHRALV
                     VLDDVPDEAFVRGLLPRSGPSSVVLTARGQLAGLAPVHRIALAALADGEALELLGKLIG
                     PGRLRTDPAAALRIVRACGALPLAVGVSGMRLAVLRHLPLAEYADRLGDPSAALDELVA
                     GDVSVRLRMASGWEDLSPDGRRALGRLAGPAQEGGFTLHGAIEALGCGERAAIRTVESL
                     IDAGAVTSPTGEVTAHAALYEVPRLLCLYAREREGALIPE"
     misc_feature    17355..17357
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18481..21111)
                     /gene="lanKC"
                     /locus_tag="D6270_RS10845"
     CDS             complement(18481..21111)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450771.1"
                     /locus_tag="D6270_RS10845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_109165597.1"
                     /sec_met_domain="micKC (E-value: 6.1e-207, bitscore: 688.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAVQETQLYCLADRTYYDTPDRLPDADSRYRLDTDPPPAGWRRS
                     AAGLWTSLVPEHTRLAEQGWKIHVSTVPDEAEATLRDTARICLRHGVPFKFLRSARALS
                     LMADKHMNRSGAGKFIAVYPPDEAAFLALADELSRALAGRSGPYILSDLRIGDAPVYTR
                     YGAYVPRWCDDGEGGRVLALRDPSGNLVPDERGVVFRTPSWVEVPPFLRPHLAARAAAR
                     DDTFPYTVTEALQFSNAGGIYLAEDRDTGRRVVLREARPHCGLDGAGDDAVTRLHREHR
                     ALTALAGLDCVPRVYGVRTVWEHHFLIEEHIEGHTLLDEIVARFALVRGAVTADDLAPY
                     VAWTEAMTGELSRALDAIHARGLRFGDLHPSNIIVRPDGRIALVDFEYATGLDDQDTPL
                     AGAQGLQAPPGTPGAEADAYALWATWLTMLMPLTEMAGLERAKALTLESWARRRYGLSA
                     DAGPARPALLHGLDASRRREAEVAALFEPHVDWAEIRARLLAGIHAGATPERTDRLFPG
                     APGLFATGGTDLAHGAAGVLYALHRTGAPVPVEWTDWLADAAYRRDPAEAGGLFDGLPG
                     TALVLTLLGRAEAGRELWDRAMSAAPPPASADLFDGRAGLALAALRLARAGGPTAPGTG
                     LVDAALRTARDLDRLARGGSVDGMRLPESAGLLRGLSGAALLHLELHALTGESWLREAA
                     RTALEREAGHLVTMDDGTIQVRDGRRHLLYLNQGSSGVALVAQAYTARHEHPALSALIP
                     GVRAGCAMEFVREPGLFTGRAGLAAAAGQLSPDGRTGPEVLASVTNLTWHLIADEDRLL
                     VPGATLRRCSADLATGAAGLLLSLDFLSSGTDGTGGTGGTGGAGRTGEVAGIGGSGLLE
                     LLTLG"
     gene            complement(21168..22439)
                     /locus_tag="D6270_RS10850"
     CDS             complement(21168..22439)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577226.1"
                     /locus_tag="D6270_RS10850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_109165596.1"
                     /transl_table=11
                     /translation="MTKPLRENRDFRLLWLSGLFAVLGGQMSALALPLLVLKETGSPVQ
                     AGAVGTVSVGAVLITMLPGGVMADRIERRRLMRLCDVGSLTVVTALTIAVLYGHAPMAL
                     VLLVAAAGAVISSVYAPAVFGLMRAVVPADQMGTATARLQARTQTARLVGPLVGGALFG
                     LHPALPFAVEALGLLASTVCVALVRTRSRARTAAGSAFSKRELTAGLTFLWQIPYLRTV
                     LLIFGLGMNFAFGSLTFIALTAFSDGGRSGIGGGFVISCVSAGALAGALFAPRIKPARH
                     SRVLIVATCWTCVAAAGVMAWLSRPLVAGLMCALCMFLSTVASIGFLSKLLVVTPEEKV
                     GRVQSAAGFLSSMVQPFGPLAGGALLMAFGARWAFTLTGCVLAVSALVVTFAASARTEP
                     APPAHEPEPTEPVAPAAKHATPGT"
     CDS             22452..22571
                     /gene="allorf_2369683_2369802"
                     /locus_tag="allorf_2369683_2369802"
                     /protein_id="allorf_2369683_2369802"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVGGGVGRWSVRRGGVPGVVSGGSGGWCPGVPGGGVRGG"
     CDS_motif       22452..22508
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVGGGVGRWSVRRGGVPGV"
                     /locus_tag="allorf_2369683_2369802_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       22509..22571
                     /prepeptide="core"
                     /locus_tag="allorf_2369683_2369802_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="1663.8"
                     /monoisotopic_mass="1662.8"
                     /core_sequence="VSGGSGGWCPGVPGGGVRGG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVGGGVGRWSVRRGGVPGV"
                     /leader_location="[22451:22508](+)"
                     /alternative_weights="1681.8"
     gene            complement(22728..22886)
                     /locus_tag="D6270_RS32940"
     CDS             complement(22728..22886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608636.1"
                     /locus_tag="D6270_RS32940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_202418325.1"
                     /transl_table=11
                     /translation="MSENTKPAADENNENESAEVEAHSVLDLQETSVDKVVAPGSCVSV
                     LSVVMEN"
     CDS             22932..23102
                     /gene="allorf_2370163_2370333"
                     /locus_tag="allorf_2370163_2370333"
                     /protein_id="allorf_2370163_2370333"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRTAVSGAAGRCLPLPRKLGAPASKTLRRRYGGGMGPARRPWTRA
                     PGPPGGSPPPP"
     CDS_motif       22932..22955
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRTAVSGA"
                     /locus_tag="allorf_2370163_2370333_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       22956..23102
                     /prepeptide="core"
                     /locus_tag="allorf_2370163_2370333_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="4898.7"
                     /monoisotopic_mass="4895.7"
                     /core_sequence="AGRCLPLPRKLGAPASKTLRRRYGGGMGPARRPWTRAPGPPGG
                     SPPPP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRTAVSGA"
                     /leader_location="[22931:22955](+)"
                     /alternative_weights="4916.7"
                     /alternative_weights="4934.8"
                     /alternative_weights="4952.8"
     gene            23227..24306
                     /locus_tag="D6270_RS10855"
     CDS             23227..24306
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608637.1"
                     /locus_tag="D6270_RS10855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_109167500.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-11, bitscore: 43.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELAELVGLRPFPAAGLLLGLTRRCPLRCGHCSTGSDLTVREEPD
                     ADRLLRFVGSFTSENRPDVVMLTGGEPLLLPTLAGELSFLARRAGSRTAVLSGMFFARS
                     KEIPPAILRAIAQVDHFSASLDVHHEREVARADVFRALHRIRESGVSVSFHLTGTGADD
                     PYLADITRAIDQEFGGRVPSLVNEVRPFGRAASWARPARGGPDPSAAAPCSMAAWPVVA
                     FDGTVLACCNQDTVDRRPAPAHLDLGHIGSDDWETVRRRALESPVLRMIRTVGPAHLAA
                     RSGAAPRPGSYCDGCRALGGDEAVAAGARAVAAGPAGALLDLAAAQRGALGGPEGVVRR
                     HGCSAYAPLVGARGAGSTR"
     gene            24435..25076
                     /locus_tag="D6270_RS10860"
     CDS             24435..25076
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124647.1"
                     /locus_tag="D6270_RS10860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_225977039.1"
                     /transl_table=11
                     /translation="MWRAEGLVDRYRTYLSTMHAVIRASVPLMELALWRASDDPGDPLS
                     EPLSAYLVEHIREEAGHDAWLLEDLVAAGATAGDAPGPLPPPDVATLVGPQFYWIENHH
                     PVTLLGYIAVLEGYAPAPGLTDRIASLTGLPAAALRTVREHAALDTDHLDELYALLDRL
                     PLTRDQEAAVAVSALHSLDALTRLFVRLGRSAPAPSLRGAGPTSPTGVTP"
     gene            25073..25303
                     /locus_tag="D6270_RS10865"
     CDS             25073..25303
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959336.1"
                     /locus_tag="D6270_RS10865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109165595.1"
                     /transl_table=11
                     /translation="MTGPPQPPPTDPEQLPTEAVLYEAGFPVDLLTEEQRQVLGELSPQ
                     ELTLLLDVKSRLDAVGPEVQAHGEIAGGALF"
     gene            25475..28639
                     /locus_tag="D6270_RS10870"
     CDS             25475..28639
                     /GO_process="GO:0009190 - cyclic nucleotide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0035556 - intracellular signal transduction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511305.1"
                     /locus_tag="D6270_RS10870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_109165594.1"
                     /transl_table=11
                     /translation="MTCPSCRQELPSTARFCSSCGTPCAGPAAAAPAPVPPPAEDERKP
                     VTVLFCDLVGSTALSGVLDPETLRTVTLRYFEAMSAQIVARGGTPEKFIGDAVMAVFGV
                     PVVREDDARRALAAALGMRRALDALNEELDASLGIRLTTRVGVNTGQVVAGSDATARQA
                     LVSGEVVNIAARLEQNAGPGEILIGPQTLLAAGPTVQAEPTGPLRLKGKRESVQAYRLL
                     ALGADDPELLRRFDAPFVGRTTELDALRRALAETVQEDRPGLLRVTGEAGIGKTRLVRE
                     WLTRHGGAGAFAYGAGRCRTYGDHGTLAPLADAVRSLLPPALAAGDEAVDDAMALLTGG
                     LLRDGTPNAPFEDMCAALTVVLTRTGRERPVVLVLDDWHAAAPLLVRTVDRLTGAAGPA
                     RTLVICAGRPEEDRGAGAAGGRRGHLQLTGLPREAAARLAAGLAQLDGRPVPADDRLLA
                     RSEGNPLYLEQLLVGDRAAAPTPEGELPPTLQALLGARIGALARAERGVVDLAAVIGRE
                     FAAAELVRLELAVRTAERPDAPGPRDLGGVDEALAALARRRLVEPAPSGAGESSAYRFS
                     SGLVHEVAYASLSKRAKAERHAWAAELPSVERTGDGAVGGHLERAYRYRAELGLLDDRA
                     RALRDRAAAALGRAGAQAAARSDLHWAHGLLERAVELRPEAARAVLGLGEVRVALGRTE
                     EGAELLRTVRDLATTPVESAHARLALAVLDPAASPGPAATARAVLPVFEAAGDAIGRAR
                     AHLRLAQQLQQSGRHEEAERDHARALEHAVAAGAEPERAGALGAIGISLWRGPVPVPEA
                     VERCRALLAAHGSGRPTVRVTLNCPLAVLYGLQDRPDEAYACLAEAERLAGKLGFAEAE
                     VFLPVFRATVEALLGRDAEALELLARADTAARRMGAAGMRTALALDAARLELDAGRADR
                     AVEWLAGIGGASGLSRADAVDLEGLRARLAAPDRPDEALHHADRAVRASLLTDSPLVQA
                     SAELDRARTLAALHRTADAVAAARSAGEHFAHKGHLPGTRRVAAFLGAQTGPPAMATTS
                     TTREGS"
     gene            28643..29560
                     /locus_tag="D6270_RS10875"
     CDS             28643..29560
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046107.1"
                     /locus_tag="D6270_RS10875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_109165593.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.1e-22, bitscore:
                     78.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTTEATATAGTRAAPGQGLTWSLRGRGPEDVPVLGDPGPPGGQP
                     AGPALGRGVRVCVVDSGVERDHPLVGEPAASWVVVKDAESGEITVEPTTTGDTCGHGTA
                     CAGIIRRTAPECEIHSVRVLGERFSGTGDILMAGLRWAVEQRFDVVNLSLSTTRTRFAQ
                     ELHSLADSAYFARTVIVASAHNTPVESFPWRFASVISVGSHQEDDPDLHLYNPQPPVEF
                     FGPGQNVTVPWLGGRTIRTTGNSFATPYVAGLCARILSAHPRMTAFQLKNALYLSAANV
                     RHEPAAAHPRPSTAAGDTRDDSED"
     gene            29544..30134
                     /locus_tag="D6270_RS10880"
     CDS             29544..30134
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511303.1"
                     /locus_tag="D6270_RS10880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GAF domain-containing protein"
                     /protein_id="WP_109165592.1"
                     /transl_table=11
                     /translation="MTPKTESAPAPFTPADAPRGELLQSVVDVARAIFGAAASSVLLLD
                     EEADELVFQAVSGEGQEFLVGRRFPAGRGIAGWVATSGEPMVVDDLADDPSFDRSLAES
                     TAYVPNSLMAAPLISDARVLGVLEVLDASPQARSSVRELDLLAMFARQAAAALRVITPE
                     PVAVSAGRVLDGAEREDALRLLGSLEQVLRGTA"
     gene            30211..30999
                     /locus_tag="D6270_RS10885"
     CDS             30211..30999
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018488901.1"
                     /locus_tag="D6270_RS10885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_109165591.1"
                     /transl_table=11
                     /translation="MKLAFSTLGVPGMPVAEVVRLAAEHGYRGVELRAHPEEPVHLGLS
                     SLERADVVEVFKAAGVEILTVAGYVQVASEGDDEAISAELAELVKLARDLGARYVRVFP
                     GGGDQDPADADATAARRLGSAAPAAADIGVTILLETHDTHRAGADVARIVGTVGHPRIG
                     AIWDVLHTWLSGEDPTASHAVLAPHLGYVQVKDVASADDLTPLPLGAGVLPLAACLEPL
                     GPETWVCWEYEKRWHPDAADLPGLLGAGREHLLRVGAPKG"
     misc_feature    30212..30226
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 gccgcgttca tcaggtccag cgcgctgtgc tgacagccgt tgcccaggtc cttgcgcggg
       61 cccgcccagt gggggccgta ctggtccagg ctggtgcggt tctccgcgta cgccgtgtcg
      121 gcctggcggt gcaggtaggc gctgtacggg cggtccggga gcgccttgtt gagcaggccg
      181 aggcccctga cgtacgcccc cttgaaggag tcgccgtccg acgtgcagcc ggtgccgtcg
      241 ggttcgtacg gctcgtggag ggtgccgccg gggttgaggt aggacgaggt ggtcgaggcg
      301 tcggccaggg tgcgggcacg ggtgaggagc gtcgggtcac cggtggcgcg gttaagctcg
      361 gccagggcgg cgaggacgac gccctggttg tacgtccagg ttgtgtcgcc gttgttcgtg
      421 cagtcgtccc gcagaccgtc gttgaccgtg ttgccggagt tgatcaggcc gctggaactg
      481 aaccacgccc agccgtcctt cgcccgccgg aggtaggtcg tgtcaccggc gatgcggttg
      541 tggagcgcgg cgctgagctg gatgtacagc tcgttggtga tcgcgttctt gtacggcttg
      601 tccgtggccc actgcacacc gccgccgcac gtgcccgtcc agtaggcggc catgtggtcg
      661 gcgtccttgc gcgcggtgtc caggtagcgc cgctcgccgg tcaggtcgta cgccgccacc
      721 caggcgaggc cccaccaacc ggtgtcgtcc agataggagt tggtgaagtc accgccctcc
      781 gccgtgcgca gcttctcgaa ggtgttggcg atggcgtacc ggtagctcgg catgtggctg
      841 acgcggatgt tgtcgatcaa cgaggtgagc gcggtggccg aggtccacca gcccgtgaac
      901 cttccggagc cgcggtcgta gttcatcatc agggccgtcg ccgccgcctt gctgcggctg
      961 ttggcgttcc agtcgacgcg ggcccagccg gtgcaggcga tctccgcgcg gtcgcccgcc
     1021 tttccgcagg cgcggagggc gccgatgccc ccggtgcccc agtcgtccac gttgtacatc
     1081 tgcgagcgcc agccggtccg gccggccggg gtcacggtgg caccgagctt gctgcccgag
     1141 gcccaggtgc ggccgccgtc gaaggagcgg tccagccagg tctggtcgcc ggccgccccg
     1201 ttgtcgatgg cggcccagcc catgacatcg ttgtcggaga ggtggagggc gatggagcgg
     1261 ccgtagaggg tggcggtgac cgggacgcgg tcggaggtcg cggcgcccgg gtcgcgggcg
     1321 tcgcagtgct tgttgcagag ggcggccggg gcggcggact cggcttcggc cgtcgcggtg
     1381 ggggccgtgg ccgccggagc tgccacggcg gtggacgtgg cggcggggcc caggagtgcg
     1441 gcgagcgtga gggccacggt caggcgtacg gccgtgggca gggccgctct cgcgcggtgg
     1501 cggggcagga cgatcggcat gggggcgtcc tccggcgggt ccgtcaggag aggggggtgc
     1561 ggggggtggc tcgcgtctca gcgaacccgt cccgccctac cgccgtcaag ggcacagcag
     1621 ccggacccac gcaggacagc aggtcaaccg cctcgtggcg caggggattt gggcccgtgc
     1681 tgggcccctg ggcccaacag tccctcgcgc accggacgta cccccggcac cgccgctcca
     1741 ggcatgccgc ggtgacgcgt caggcggcgc gggtcagctt cttcgccgtg ctgcagtggc
     1801 gggtcctcgt gtgccgccac agctggacgg ccgtcagccc gagcagggcg gtgaacgcca
     1861 ccaggaggac cgccgcgagg tgcgtctgcc ggccaccggg atcacgttcc atctggagga
     1921 ccagcccgag cagggagagc gccatcccca cggcgtacac cgagcggacg cgccggagct
     1981 gacgtacagc gcgaggggcg agggctacac gcttgatgaa ggccatgtgc gccggatacc
     2041 cccgggacgc cgagccagtc accgccgttg gagcggttcg gtggagggcg tgtcggcgcc
     2101 gtggcagccg ttcgggggcg gggggccgcc acacccccga acggcgcagg tgagggccgg
     2161 tgccttggcc ctcactgtgt tgttcggagc catggctcgt ccggatgggt cccagcaaga
     2221 aaaatcaggc aggcttgcgc catacggaga tgtgtcgggg cgagtcctgg gtgaagggcg
     2281 tcccgtccca gtccgcgacg cggcgttccg gaccgaggcc ggcgatcttc gccatcaggt
     2341 ccagctccgc cggccaggcg taccggtggc gggagttgct ccggcggtag cggccgtcgt
     2401 caccgtcgcg cgtgaggtgg tgcgagacca ggatctgttc caccaggtcg aacgtgtcga
     2461 agccgagatg ccgctcggag acgtcgaacg gcaccgcggt ccggccgggc ggcagggagc
     2521 gaagtggcgg cactcccagt tcgatgacga atcggccacc aggttccagg tggcgtgccg
     2581 cgttgcggaa gcattcgacc tgctcgtcct gggtgagcag gttcgagatg gtgttgtaca
     2641 cgaggtagac cagggtgaac gtgccgggga ccgtcgtggt ggccatgtcc ccgatggtga
     2701 ccgggagcgc gctctcgtcg atcttgcggc gcagcgccgc aaccatgtgt tcggacagct
     2761 cgatgcccac caccggtacg ccacgttccc gcagcgggat gcccacacgt cccgtaccga
     2821 tggcgaactc cagggcccgg ccgtctccgg ccagctcggc gaggaagtcg agagcggggc
     2881 cgaggacggc gggtgaggag ttctcggcct cctcggtgtc gtagcggtcg gcggtctcgc
     2941 gggtccacag ttcgctgctc gtcacgggca ggcactctgc cgggtggccc ggggccctgt
     3001 cgacgcatta agacgtcgtc cgcgtcccgc gcgcgcccgg aggtgcaggt gggcgcggaa
     3061 gggccgccct tgtcgcggtg gccgcttcct gcccgtgccc ggacgtcagt tggccagcca
     3121 gagcgccagg ttcagcgccg acgcgtagcc gacccacagc aggtacggca ccagcagcca
     3181 ggccgcgcgc cggtccaccc gggccgagag cagcacggtg gtcaccacgg ccgccagcag
     3241 cagggcgatg tcgaggaagg cgagtccgta ctgctcggcc gcgaagaaca gcggcgtcca
     3301 cagcgcgttc agcgccagtt gcacccccca cgccacgagc gccggccggc ggcccgggcc
     3361 ggggcggcgg gacaccagcc agcccgccac cgcgatcatc ccgtacagca ccgtccacac
     3421 cgggccgaag agccagccgg gcggggccca tgcgggcctg tccagggcgg cgtaggtgct
     3481 gcccgcgtca cctgtcgcga tcgcgcccgc ggcggccacg ccgtagcaga gggcgaggaa
     3541 cagcaggagc gtgagccaac cccggtggcg ggatggtgtc gctgcggtgg aggtggtgcg
     3601 ggtcggtggc acgggtgggc tcctgttcct cggtcttcgt tctctgcttc ccgctgttcc
     3661 ttgttcccgt tccccgcttc ccgcttcccg atctccgctt cccgcttccc gcttcccagg
     3721 gcatttctcg gccggtgccg ggagcggatg cttctaaaag gcagtgaaat tcggtggccc
     3781 ggccgccgcc cccgttgtta cggtgctcgc gcctcgaccg cggtgcccga ccgcaggtga
     3841 cctctgggcc gtgtgccctg gaaagcagtt gatgtatgcc ccggccagtg gttccgagcc
     3901 tccctcgtcg cgcctgtggc gccggggcga ccgggcctga ccgcgtgcgc agccgccgcc
     3961 gtacgtccac cgtctgctga cgcaccacgg cccgcggccg aaccccgacg cgcgccacgc
     4021 gctccggcgc tccgacacga ggggtgctcg gtacttccct gctgcttcgt tcctcacctt
     4081 cggcaaggag tatccgggtg tcacacgaca acccccgcca ccgcacgacc atgtcctcac
     4141 ccatgtccgt gtcctcgctg gacaccttca cctgcgtccg ctgcgggctg accgtcgccg
     4201 cgtccgcgcc cgacggcggt cggcgcaacc actgccccag ctgcctccac tcccggcacc
     4261 tcgtcgacca ggtcgagggc ggtccctccg attgcgaggg ccggatgacc ccgatctcca
     4321 tcgcggtgct ccgcaccggt gactggatgg tcgtccaccg gtgtgtccgc tgcgacgagc
     4381 tgacctcgaa ccccgtctgc ggggacgaca accagctgat cctcatgcgg atggccgtac
     4441 gtcccctggc tcagccgccg ttcccgctcg aagcgttcgg tgacctgtga cgcggcggag
     4501 agcccggccg gccgggcggc ggcgtcccca gcgagccaag gacgtgctcc acgggcccgc
     4561 cggggcgcgc ggcgacgcgt tccggtgcgt cggctgccgg ctcgatgtct ccctggtggc
     4621 gccgggcacc gcccatcgca accactgccc gtcctgtctg gtcagcctgc atgtggaccg
     4681 gcgggtaccg ggcgaccggg cggcggggtg cggtgggcgg atgacggctc tgagcctgtc
     4741 cgtacgggcg gacggggagt ggatgctcat ccacctctgc ctgacctgcg gcgagctcag
     4801 cgccaaccgc atcgcgggcg atgacaaccc tctggcgctg atacggctgg cgctgcggcc
     4861 gctcgccgat gccggtatcc ccgcgcgggt catgctcgcg ctgtgatcgg ggggccgtgc
     4921 tgtgatcggg ggccgtccgg tgttcgccgg gcggcccccg gcccacagcc ccggcccgct
     4981 ccccgaagag cgaggagagg ccgagaagca agaatggggc ccggcctcgc ggccggaccc
     5041 ccctcgcttt cccccgtcgg gccttcccgt tccccccgga cccctccccg gaagtcccga
     5101 cgccatgtgt gacccgggag ggtacgcaaa ggttgcagcc ctttacgatc tctttacctt
     5161 cggcctcgat cgcggtcctc agcaggcatg ttgcccatag cgctccgcca cctcggccag
     5221 cacgtccgcc ccgtcgcggg cccacagcgc ctcgttgaag atctccacct cgatcgggcc
     5281 gtcgaagccc gccgcctcga cctcccgacg gaacgcccgg aagtccacgc tcccgtcgcc
     5341 cagttggccc cgccccagca gcacgcccgc cgggagcggg gtgatccagt cggccagctg
     5401 gaaggagtgg atgcggccgg ccgctcccgc gcgggcgatc tcggcggggg cccggtcgtc
     5461 ccaccagacg tggtacgtgt cgacgaccac ccccacctgc tcggccggga agcgttccgc
     5521 gatgtccaaa gcctggccca gagtcgagac cacacagcgg tccgaggcga acatcgggtg
     5581 cagcggttcg atcgccaggc ggacgccgcg ctccgccgcg tacggggcga gttcggccag
     5641 cgcgtccgcc acccgttcgc gagcgccgta caggtcgcgg ctgccgggcg ggaggccgcc
     5701 ggagaccagc accagggtgt ccgtggacag ggccgccgcc tcgtccaccg cccggcggtt
     5761 gtcgtccagg gcgcgggccc gctcctccgg gtccagggcg gtgaagaagc cgccgcggca
     5821 gaggctggtg acggagaggc ccgcgtccgc gatgagccgt gccgtgcgct ccacgccgta
     5881 cgcctgcacc ggcgcccgcc acaggccgac cttgccgatg ccagccttgg cgcagccctc
     5941 cgccagctcg gggagcgacc actgcttgat ggtctcctgg ttgagcgaga ggcgggacag
     6001 gtgttcgtcg ttcatcgtgt gcctccgttg accgccagca gcgcccgcat ccggtgggcc
     6061 gccagctccg gatcggggaa caggcccaag ccgtccgcca gctcgtacgc cttcgccagg
     6121 tgcggcagcg agcgcgccga ctgcgctccg cccaccatcg tgaagtggtc ctggtggccg
     6181 gccagccagg ccaggaggac cacgcccgtc ttgtagaagc gggtcggcgg ctggaagagg
     6241 tgacgggaga gtccgaccgt cgggtcgaga agggcccgga agcctgccac gtcccccgtg
     6301 tccagcaccc gtaccgcgtg cgccgccagc gggcccaacg ggtcgaagat gcccaacagc
     6361 gcgtgactga agccctgttc gtcacccgcg atcagttccg ggtagttgaa gtcgtcgccc
     6421 gtgtagcagc gcaccccgcc cgggagccgt cggcgtacgt cgatctcgcg ggccgcgtcc
     6481 aggagggaga tcttgatgcc gtcgaccttg tccgggtgtt cggcgatgac cttcaggaac
     6541 gtgtccgtcg cctcgtccag gtccgtgctg ccccagtaac cgtcgagcgc cgggtcgaac
     6601 atcgggccca gccagtgcag gatcaccggc tcggaggcct ggcgcaggag gtgcgcgtac
     6661 gtggacaggt agtcctccgg gccccttgcc gcccgggcca gtgcgcgcga cgccatcagg
     6721 atcggctgta cgccgttctc ctcggcgagg gccagttgct cctcgtacgc cgacctgacc
     6781 tcggcgaggg ccggctcacc ggacgccggc aactggtccg tgcccacgcc gcaggcgatc
     6841 ctcccgccca ccgccttcgc ctccgccgcc gaccggcgga tcagttcggc cgcgcccgcc
     6901 cagtccaggc ccatcccgcg ctgcgccgtg tccatcgcct ccgccacgcc caggccgtgc
     6961 gaccagaggt ggcggcggaa ggcgagcgtg gactcccagt cgacggccgc cgggtcgtcg
     7021 gggctgatgt ccgcgtacgg gtccgcgacg acgtgggccg ccgagaagac cgtacgggag
     7081 gtgagcggcg cccctcccgg cgcgagggcg agaggggtcg tacgcggcgt gtacgggccc
     7141 tggggcagcg ggacaggagc cgtcacagcg tcagctccgg gacctcgaag cgacggccct
     7201 ccgccgacga cttcagcccc agctcggcga gttggacgcc ccgcgcgccc gccagcaggt
     7261 cccaggtgta cggctcgtcg agagccacat ggcgcaggaa cagctcccac tgcgccttga
     7321 agccgttgtc gaactcctgg ttgtccggaa tctcctgcca ctggtcgcgg aacgactccg
     7381 tcaccggcag gtccgggttc cagaccggct tgggggtcga agagcggtgc tgcacgcggc
     7441 agttgcgcag gcccgccacg gcggagccgt gcgtaccgtc gacctggaac tccaccagct
     7501 cgtcgcggtt gacccgcacc gtccaggagg agttgatctg cgcgaccgcc ccgcccgcca
     7561 gctggaagat gccgtacgcg gcgtcgtcgg cggtcgcctc gtacggcttg ccgtgctcgt
     7621 cccagcgccg cgggacatgc gtctgcacat gggccgtcac ggaggtgacc tggccgaaga
     7681 gctcgtggag cacgtactcc cagtgcggga acatgtccac gacgatgccc ccgccgtcct
     7741 ccgcgcggta gttccacgag gggcgctggg cctcctgcca gtcgccctcg aagacccagt
     7801 agccgaactc cccccggatg gagaggatct cgccgaagaa tccgccgtcg atcaggcgct
     7861 tcagcttcag caggcccggc aggaagatct tgtcctggac cacgccgtgc ttgatgcccg
     7921 cgtcccgggc gagccgggcc aggtcgaggg cgccctcgac gtccgtggcc gtgggcttct
     7981 cggtgtagat gtgcttgccc gccgctacgg ccttcttgat cgcctcgacg cgggccgagg
     8041 tgacctgggc gtcgaagtag atgtcgaccg tgtcgtccgc gagcaccgcg tccaggtccg
     8101 tcgaccactc ggtgagcccg tgccgggccg ccagctcctc cagggcgtgg gcgcggcggc
     8161 cgacgaggac gggctccggc cagagcacct cgccgtcgcc caggtccagg ccgccctgct
     8221 cgcggatcgc gaggatcgaa cgcaccagat gctgccggta tcccatgcga cccgtcacgc
     8281 cgttcatggc gatgcgcact gtcctgcgtg tcacgaagtt ccctccatac agccgtagca
     8341 agcgctttct atacgagatg acgctagcct gcggacagcg gccggacaag aggggcgccg
     8401 cacgtgactc acggaggaaa gcgatgacag tcaccctggc ggacgtggcg gcccgcgccc
     8461 gggtgtcccc ggccaccgtc tcgcgtgtgc tgaacggcaa ctacccggtc gccgcgtcga
     8521 cccgggagcg ggtcctgcgc gcggtggacg atctggacta cgtgctcaac gggcccgcca
     8581 gctcgctggc cgccgccacg tccgacctgg tcggcatcct ggtcaacgac atcgccgacc
     8641 ccttcttcgg gatcatggcg ggggccgcgc agacccagat cggcggaccc ggggacggct
     8701 ccgggcgggc gggcggcgag aagctggccg tcatctgcaa caccggcggc tcccccgagc
     8761 gcgagctcac ctacctcacg ctcctccagc gccagcgcgc cgccgcggtc gtcctcaccg
     8821 gcggcgcggt ggagagcccg gaccaccagg ccgccatgtc cgtgaagctg gccaagatgg
     8881 cggacgcggg cacccggatc gtcttctgcg ggcggccccc gctccccgac ggggacgcgc
     8941 tcgtcgccgc gctcgccttc gacaaccggg gcggcgggcg gcggttgacc gagcacctga
     9001 tctcgctggg ccaccgcagg atcggctacg tcgccgggcc gcccgaacgg accaccaccc
     9061 ggcaccggct ggagggccac cgcgaggccc tgcggggcgc cggactcgac acggtgcccg
     9121 aggacgagga gcggctcacc gtgcacgggc cctacgaccg gcgctccggg tacgaggcca
     9181 ccctcgagat actgcgccgc gaaccgggcg tgacggcgat cgtcgccgcc aacgacaccg
     9241 tggcgctggg cgcttgcgcc gccgtacggg accaggggct gcgcatcccg caggacatct
     9301 cggtggcggg cttcgacgac ctgccgttct cggtggacgc ggtcccggcg ctgacgaccg
     9361 tacggctgcc gctcttcgag gcgggggcgc gggccgggcg gctcgccatg ggcaaggaga
     9421 acccgccgcc tggcggaatc gccaccatcg ccgccgagtt gatgatccgg gggtcgacgg
     9481 ccccgccccg ggtggggtga ggcccccggg gtgagtcccc ctggggcgag gcctccggtc
     9541 gggctcaatc cgcttcgccg cgaggccggt tgtccgcctt cacgctaccg ccacgccttc
     9601 ccccgtcggt accttcacct ggccgtcaca cacgtgccag tcggggaccc agctcaggag
     9661 cgggccggtc ggaatgaaca ccagacacct catggccttc gcagaagtcg ccacgtgccc
     9721 ggccctggcc cgggtctgcg tcacgctcgc ggcgcggggg gaggctcttg cccgggtctt
     9781 cggccccggc ggcctctcct acggccggga tctgcggcgc agagtcggcc ggggcagggc
     9841 tgtccccgga ccgctgaacc aggcagggca ctgagcgcac ccagctggcc cacgggccgg
     9901 gagcgaaaga tgggggcaac tcccccatgc gccagaggag tcccccctcc aggatggttc
     9961 gtgagcggtc cggtgggccg ctcccgacct gggaggtgcg atggagaagg aactgatcgg
    10021 cagcggcggt acgggggccg ctgcccgtcc cgccctcccg ggcacgaacg ggtccgtcgt
    10081 gtccgcccgg tccgccgctg ccgggtccct cgcctcctct ccgtcggccg cagcggccgt
    10141 cacggcggcg gaagccgcac gtacgaacca cctccccacg aacgcggcga gcaagccgaa
    10201 cgccaccggc gcaggcaccg gcgctggcag caccacgccc ggcaccggcc cctggtggct
    10261 ccccggcgtc gtcggggaac cgcccctgtg cgagcccgac tgggtcgcct tcgtgcgggc
    10321 cgtcatcgcc gacgcgccgc cccgggccgt cgtcgccgag cgggactacc ccggcctcac
    10381 cggattcgcc ctcgtcgtgg ccccgttcgc cgagcgggcc gccgggcggc tgctgacctc
    10441 accgtcgaac aacgccgtac gggccgggaa cgccgtcggg ctcgcccccg tactggagga
    10501 cttccgctcc cacctggtcc ggcggctggc ccggctcgcg gcccggacac tcgtgctgga
    10561 actgcacaag gcgcggcggg cgggacggct ggccggggag gcgcccgagg agcggttccg
    10621 cgacttcctg cggcggacgg cggggcggga cgggctcgcg gccttcctca cctcctatcc
    10681 cgtgctggcc cgcatcctgg cccggacgag cctggccgcc gccgacgcct tcaccgagat
    10741 gctcggccgg ctcgccgacg accgggagct gctggccgcc tccggtgtgc tgggcgaccg
    10801 gggggcggag ggcgccggtc gcgggccggt ggcgctgacc ggggtcgagg ccggtgcggg
    10861 cgacagccac cgcgggggcc gctcggtgat gctgctgcgg ttcaccgacg gcacccggct
    10921 ggtctacaag ccgcgcccgc tcgcggcgca ccggcacttc aactccctgg tggaatggtt
    10981 cggttcgctg cccggcacac ccggcctgcg ggcgctgcgg gtgctggacc ggggtgacta
    11041 cgggtgggtg gagttcgtcg aggagcggcc ctgcacctcg accgccgaga cccatctctt
    11101 ctaccggcgc cagggcgcgc tgctggccct gctccatctg ctggacggca ccgatctgca
    11161 ccaggagaac ctgatcgcct gcgggtcgca cccggtcctg gtcgatgtgg agaccctctt
    11221 ccacccgccg ctcacccagg cgcactcggc cgaccccgcc gcccgcgccc tgcacgactc
    11281 ggtccaccgg gtcgggctgc tgccgcagct gctggtcggg gactcggcgg ctctcgacgt
    11341 ctccgcgatc ggcggtggcc gggccgcctc ctccccgatc gaaaccgccg actgggcgga
    11401 cgcgggcacg gacacgatgc ggctggtacg gcgctccgcg cggttcaccg agtccgccaa
    11461 ccggccccgg ctggacgggg ttcccgccga cccgtcggcg tacaccgact ccctctgcga
    11521 ggggttccgc gtcggctaca ccgccatcag cgactaccgc gacgaactgc tcggcaagcg
    11581 cggcctgttg acggacttcg cgggcgacga ggtacgggtc gtgccccggc cgacctgggc
    11641 ctacaccacg ctgctggacg agtcgaccca ccccgacctg atgcgggacg ccaccgaacg
    11701 cgaccaggtc ctctccctgt tgcgcacccc cgccctgggc gtgccggcgc tgcccgggct
    11761 ggaggacgag gagatcgagg agctgtggaa cggcgatgtg ccggtcttcc tcacccggcc
    11821 cggctccagc gatctgtgga gcggcaccgg gcgcggggtg cccgtcgcac ccggccccac
    11881 cgggctcgcc cgggtcgaag agaaggtgcg ggccatggac tcggtggacc gccaggacca
    11941 ggagcggatc atccgggccg ccatggtgtc cacctccccc gaaccgccgc accgggcgga
    12001 ggacggcacg cgggcccgta cggccgcgac ggcccccgag ccggagcaac tcctctccgc
    12061 cgcacgctcg gtgggtgacc agctcgtctc gctcgcctac cggcacgaga cccgcaccaa
    12121 ctggatcggc ctggagctgc tgggcgagcg ctactggcgg ctcgcaccga tggcggccga
    12181 cctcgccggc ggctacaccg gtcccgcgct cttcctcgcc cagctggccg ccctctccgg
    12241 cgccgagcgg tacgccgagg cggcccgcga ggcgctggcc ccggtgcccg ggctgctgga
    12301 cgcgctgcac ggccgggtgg acgacctcgc ggtgctgggt tcgggggcct tcgcgggcct
    12361 cggcggcatc gcgtacgccc tggccgaggt gggctcgctc ctcgacgacc tcacggtcct
    12421 ggagctggcg ggtccggcga cccggctggc ctgcgcggcg ggcgccgccg agaacgggta
    12481 cggggtgcgc ggcggcgcgg ccggcgggct ggtctcgctg ctcgcggtgc accgcaccac
    12541 cggccgggcc gaggcctggc ggggcgccga gcgctgcgcc gaacggctcg ccgtcgcacc
    12601 gctcccggcc tccgggggct tcgcggaggg ggccgcgggc atcggctggg cgctgctgcg
    12661 cttctccgcg gcgggcggcg gtgagcagta ccgtacggcg ggactgcggg ccctgcgccg
    12721 ggcgaccgtc gaggtgacgg ggggccgggc ctggtgcgag ggggccgcgg gagtggccct
    12781 cgccgtcgcg gacagcccgg acgcgctcgc cgacccggac ctgtccggct ggctggcgga
    12841 gcgggccgga gagctggcgg actgcgcgcc gctcgccgac gacagcctct gccacggcga
    12901 gctcggcctg ctggagctgc tcggccaccc ggcgctgacc ggtgaccgcg ccccgtgggt
    12961 gcgccgggcc gggacgctgc tggccgccgc cgaccgggag gggccgcgct gcgggacccc
    13021 cggacacgta ccgcacccgg ggctgctcac cggcctctcg ggcatcgggc acggactgct
    13081 gcgggcgggg ttccccgacc ggatcggctc cgcactgctc ctccacccgt ccgcgggggt
    13141 cgcctagacc ggcaccctgc gactgttatc agccgttccg gctcttcacc gcggaccggc
    13201 acctttaccc aacccgttgt cgacctactg tcagaaaccc ttctttcagc gttcattcgg
    13261 ttcagaattc actactcggc agagaatgag gcagagatga cgcacatcag cgaatcggcg
    13321 atgcagggat ccggcacgtc cgcccacgag ggcgcttacg accacccggc cgggcagata
    13381 tccctgggta tcggcggcgg gctggggatg cgcagcagac tcctcagcgc ctcggagggc
    13441 gaggccggca acaccatcga ccttccgtgg accaccatga ttccccttta accactgttc
    13501 tgggccgcat tgtgacgtat tgagccactg ccggatgagt tacgactcaa gtagcctgcg
    13561 gccatgcgtg ccacttcgcc ggtcatcgtc gggcgggacg aggagatcgg cctgctgagc
    13621 agcgccctgg acgccgtgca acggcgttca gggcgcgcct tgttcttcct cggcgaggcg
    13681 gggatcggca aatcccggct ggtgggtgag tgcgcctacc gggcctacgg gctgaacatg
    13741 ccggtgctgc gcggccgtgc cacgtcgacc gggctcgtgg tccctttccg gccactcgtg
    13801 gaagccctct cctcccgctt ccgggccgcc ggcaccccga ccgaccccga gctggccccg
    13861 taccacccgg cgctggcccg gctggtcccc gaatggcgcc aggaggcctc ccccggctat
    13921 ccggagaccg tcgtggagct ggcggaggcg ttgctgcggc tgctgtccgt gctgggccgg
    13981 gagtccggct gcgcgatcct gctggaggac ctgcacgaca gcgacacgga gaccgtcgcg
    14041 gtggtcgagt acgtcatcga caacctggcc gacctgccga tcctgctcct ggggacgctg
    14101 cgcccggagc cgggggccgc actcgatctc gtacggtccg cggagcgccg ccaggccgcc
    14161 accgtcaagg agctgaagcc gctcgccgag gatcagatgc gggcgctgac cggtgcgtgc
    14221 ctggaggcgg cgcccgagga gatacccccg gtggtgcacc agcggttggc cgaacgcgcg
    14281 gggggcaacc cgtacttggt ggaagtcctg ctggccgacc tgctggacac cgatcagttg
    14341 cgccgggcgg acggcggctg ggaggcggcc gacgatcccg gcgggccggt cccctcaggg
    14401 atcgtacgga gctggacgcg cagactcgac cggctggacg agccggtccg ggagctgtta
    14461 ctcgcggcgg ccaccctggg cggccagttc tcggtctccg tgctccagac cgtcaccggt
    14521 ttcgaggacc gggcgctctt cacccatctg cggtccgccg tcgaggcggg tgtgatcgcc
    14581 cccgacggcg ccgcccccga ccggtacgcc ttccgccact cgctgaccgc cgaggccctg
    14641 atctcctcgc tcgccccggc cgagcgcgcc tcgctcgccc gccgcgccgc cgtggcggtg
    14701 gagcactccg ggcacccgct cgacgaggac gggcagcagc tcgtcgcctc cctccatctg
    14761 gccgcgggca accgctcggg cgcggccctg cggttcgcgg aggccgggag acggatgctc
    14821 gcctcagggg cccacggttc ggccgtggtg ctgctggagc gggcctgccc cctggccgcc
    14881 gacgccgacc gggccgccat cgccgagtcc ctggcggtcg cccgggccga gggcggcgac
    14941 ctggacgccg cgctggagct ggccgagacg ctgcctccgg tgcccgcgcg caccgaggcc
    15001 gccgaccggc gcggcgaggt ccacgtcaag atcgcctggg tggcggtgat ggccgagcgg
    15061 gcggccgacg cggcccgtca gatcgacgcc gcccgcaccc tgctcggcca tgagccggcg
    15121 cccggccgcc gggccgcgct cgccgtcgcc gacgcccacc tggccctgct ccccgggcag
    15181 gagcaccgat gcccctcgga gaccgagcgg gccgcccgcg aggctgcgga gatcgccgag
    15241 gccgaagggc tgcccgtggt ggcctgccag gcctggcagc tgctggcgct gctgctgcgc
    15301 gagaaggggt tcgacgaggc ggacgcctgt ctggagcgga tgctcgcgct ctccaccgat
    15361 cacgatctgc ccgtctggcg ggtggaggcc ctggtgcggc tcggggccaa cgccttcatg
    15421 cggaccgggg acgcctcccg gctgcgctcg gcgcgggcgg cggccaccga gctgggcgcg
    15481 ctgctgctga cccagacggt ggacgggctg ctcgccatga acacggtgct gtgcgcccgt
    15541 tgggacgagg cgcaggagat catcgaccgt tcgctggagg ccagcgcccg ggtcggcaac
    15601 ctctccgccc accgctatct gctgctctcc gccgccacga tggccgcgca ccggggacgg
    15661 cggcgggaca tggaccgcgc actggccgcg ttccggcggg caggcggcga gcaatcgctt
    15721 ctcgtgccgc accagttggg gctgtgcaag gcgatcggcg cgctgctgga ggaggaccgc
    15781 gggcgggcgc tggaggggct ggacgcggtg caggcctggg agcgggacca ccccagctac
    15841 ttctacctga gcgggagtta cgggctgcgc cccttcctgc gggtgctggc cggggcggcg
    15901 gaccgggagg agtacgaggc cgtacgtgcc tcgccggggg ccgggctggc ctggaacggg
    15961 cagttcctgg agctggccga cgcggtgctg ctgggccgct ccggcgaccg ggccggggcg
    16021 gcccgcctgg tggacgcctt cgacacccgc tccaccccct tcccggtcgc ccgccacctc
    16081 ggcctgcggc tggtcgcgga cgcggcccaa gccgacgggt ggggcgagcc ggtcgcctgg
    16141 ctgcggcggg ccgaggagtt cttctacggg gtcggggcgc aggtggtcgc ctccgcgtgc
    16201 cgggcggcgc tgcggcaggc cggggcgagc gtcacccagc accggggcgg ctgggaccgc
    16261 atcccgctgt cgctgcggac cagcggggtg actccgcgcg agtacgaggt gttcgtgctg
    16321 ctcccggagc ggcccggcaa ccagcagatc gcccggcggc tctccatctc gccgcgcacg
    16381 gtggagaagc acatggccag cctgctcagc aagaccgggc gcgcggaccg ctcggcgctg
    16441 tgcgagttcg cggcggagtg cgcggtggag ccggcctgag gccgcacccg tgcccccaca
    16501 acatgggggc tcggggcgct ttcggtcggg tctaccggcg gaacatgcgg gctgtccccc
    16561 gatgtgccgg tctgcgtacg gctccaggat cgaagggtac gtacggcagt ctgccgcccg
    16621 tccccgcttc cggaggcccg ctgatgatcc gacctcccgc ccgcccggcc cccggtgcgg
    16681 tgtacttctc gctcctcggt ccgctcaccg ccgtacggga cggccgtccg ctcccgctcg
    16741 ggccgcgcaa acagcgcctc gtcctcgcca ccttgctcgc gcgccccaac acccctgtgc
    16801 ccgtcgacgt gttgaccgac gcggtgtggc ccgacgaccc gccgcgcacc gcgcgcaaga
    16861 acctccaggt gtacgtgagc gccgcccgcg ccctgctcgg cggcgacgga cgggaccggg
    16921 tcgtccacgg ctgcggcggc taccggctca ccatcgacga gggcgagctg gacaccctgc
    16981 gcttccgctc gctggcccgg gccgggcggg ccgccggtga acgcggcgac ctgcggagcg
    17041 ccgcccggct gctgcgggag gcgctggacc tgtgggaggg gccgcccctg aacgacctgc
    17101 gggactccac cggggtggcg gaggaggccg agcggctgga ggcccgctgt ctgaccgtgt
    17161 acgaggactg ggccgagacc gagatcgaac tcggccgggc cggcgtcgcg gtggacggcc
    17221 tgcgcgatct ggtggagcgc cacccgctgc gggagcggct gcgggtggcc tggatgaact
    17281 cgctgcacca gtcggggcgg caggccgagg cgctggcggt ctacgacgac taccggcagc
    17341 tgctggcacg ggagttaggc ctggagccga gtccggcgat ggcggccctg taccgggcga
    17401 tgctgggccg gggccgcacc gcccggcccc aggcggccgg ccgggacacc gcgcacggca
    17461 cggcactgcc cgccgcgccc cggcacttca ccggccgccg cgaggaactg cgggaactgc
    17521 tgaccctgtt gggctccccg gacgagcggg tggtggtcgt ctcggggccc gccgggtccg
    17581 gtaagtcggc gctggcgctc cgggcggccc atctgctcgg tgacggcttc cccgacgggc
    17641 gcttccacgt ccgggtccgg cgcgaggacg gctcggcccg caccccggcc gaagtcctgg
    17701 gcgagctggg ccggtcgtgc ggggtgcggg tcccgacggt tccggcggtg ccggccggtc
    17761 cggagagcgg cccggcggcg gtgtcgcagg gcgcggagga cgcctggcag ctctggctgt
    17821 cgctgcaccg ggcgctggtc gtcctcgacg acgtaccgga cgaggctttc gtacgggggc
    17881 tgctgccccg gtccgggccg tcctcggtgg tgctcacggc acgcggtcag ctggcgggcc
    17941 tggctcccgt gcaccggatc gccctggcgg ccctggcgga cggcgaggcg ctggagctgc
    18001 tgggcaagct gatcggcccc gggcggctgc ggaccgaccc ggcggcggcc ctgcggatcg
    18061 tccgggcctg cggggcgctg ccgttggcgg tcggggtgag cgggatgcgg ctggcggtgc
    18121 tgcgccatct gccgctcgcg gagtacgcgg accggctcgg cgatccgtcg gcggccctgg
    18181 acgaactggt cgccggggac gtctccgtac ggctgcggat ggcgtccggc tgggaggacc
    18241 tgtcgccgga cggccggcgg gcgctggggc ggctggccgg gcccgcgcag gagggcggct
    18301 tcaccctgca cggggcgata gaggcgctgg ggtgcgggga gcgggccgcg atccgcaccg
    18361 tcgagtcgct gatcgacgcg ggggcggtga cctcgccgac cggcgaggtc accgcccatg
    18421 ccgcgctcta cgaggtgccg cggctgctct gtctgtacgc gcgcgagcgc gagggggcgc
    18481 tcatcccaga gtgaggagct ccagcagtcc cgagccgccg attccggcca cctcgcccgt
    18541 ccggcccgcc ccgcctgttc cgcctgttcc gcctgttccg tctgttccgc tcgacaggaa
    18601 gtccagggac agcagcagtc cggccgcgcc cgtcgccagg tcggcggagc agcgccgcag
    18661 ggtggcgccc gggacgagca gccggtcctc gtcggcgatc aggtgccagg tcaagttggt
    18721 cacggaggcc aggacttcgg gccccgtacg gccgtccggt gacagctggc ccgccgcggc
    18781 ggccagtccc gcgcgcccgg tgaacaaccc cggctcgcgg acgaactcca tggcgcagcc
    18841 cgcccgtacc ccggggatca gggcgctcag ggcggggtgt tcgtgccggg ccgtgtacgc
    18901 ctgggccacc agcgcgacgc ccgagctgcc ctggttcaga tagagcagat ggcgtcggcc
    18961 gtcccgcacc tggatcgtgc cgtcgtccat ggtgaccaga tgtccggcct cccgctccag
    19021 ggcggtccgt gccgcctcgc gcagccacga ctcaccggtc agcgcgtgca gttccaggtg
    19081 gagcagggcg gctccgctca gcccgcgcaa cagccccgcc gactccggca ggcgcatccc
    19141 gtccaccgat ccgccccgcg ccagccggtc caggtcccgg gcggtgcgca gggcggcgtc
    19201 gaccagtccg gtgccggggg ccgtggggcc gccggcccgg gccaggcgca gcgcggcgag
    19261 ggcgaggccc gcgcgcccgt cgaacaggtc ggccgacgcg ggcggcggcg cggcggacat
    19321 cgcccggtcc cacagctccc ggcccgcctc ggcgcggccg agcagcgtga gcaccagggc
    19381 cgtgccgggc agcccgtcga agagaccgcc cgcctcggcg gggtccctgc ggtacgcggc
    19441 gtcggcgagc cagtcggtcc actcgacggg gacgggggcg ccggtgcggt ggagggcgta
    19501 caggacaccg gccgcgccgt gggcgaggtc ggtcccgccg gtggcgaaga ggccgggagc
    19561 gcccgggaag aggcggtccg tccgctcggg ggtggccccg gcgtggatcc cggcgagcag
    19621 gcgggcgcgg atctccgccc agtccacgtg cggctcgaac agggcggcca cctcggcctc
    19681 gcgccgccgt gaggcgtcca ggccgtgcag cagggcgggc ctggccggac ccgcgtcggc
    19741 ggagagtccg tacctgcggc gggcccagct ctccagcgtg agtgccttgg cccgctcaag
    19801 gccggccatc tcggtgagtg gcatcagcat ggtgagccag gtcgcccaga gcgcgtacgc
    19861 gtcggcctcg gcgccggggg tgccgggggg tgcctggagg ccctgggcac cggcgagcgg
    19921 ggtgtcctgg tcgtccagcc cggtggcgta ctcgaagtcg acgagggcga tacggccgtc
    19981 gggccggacg atgatgttgg aggggtgcag atcgccgaag cgcagcccgc gcgcgtggat
    20041 cgcgtccagc gcccgggaga gctcgcccgt catcgcctcg gtccaggcga cgtagggcgc
    20101 gaggtcgtcg gcggtcaccg ccccgcgtac gagggcgaag cgggcgacga tctcgtccag
    20161 gagggtgtgc ccctcgatgt gctcctcgat caggaagtgg tgctcccaga ccgtccgtac
    20221 gccgtacacc cgcggaacgc agtccagccc ggccagcgcc gtcagcgccc ggtgctcgcg
    20281 gtgcagtcgg gtgaccgcgt cgtcgcccgc gccgtcgagg ccgcagtgcg gacgggcctc
    20341 ccgcagcacc acgcggcggc ccgtgtcccg gtcctcggcc aggtagatcc cgcccgcgtt
    20401 ggagaactgg agggcctcgg tgaccgtgta ggggaaggtg tcgtcgcggg cggcggcgcg
    20461 cgcggcgagg tgcgggcgca ggaacggcgg cacctcgacc caggagggcg tgcggaagac
    20521 gacgccgcgt tcgtcgggaa ccaggttccc ggaggggtcg cgcagggcga ggacccggcc
    20581 gccctcgccg tcgtcgcacc agcggggcac ataggcgccg tagcgcgtgt acaccggggc
    20641 gtcgccgatg cgcaggtcgc tgaggatgta cgggccgctg cgcccggcga gggccctgga
    20701 gagttcgtcg gccagggcca ggaaggccgc ttcgtcgggc gggtagacgg cgatgaactt
    20761 gcccgcgccg ctgcggttca tgtgcttgtc cgccatcagc gacaacgccc gcgcgctgcg
    20821 caggaatttg aacggtacgc cgtggcgcag acagatccgg gcggtgtccc gcagagtggc
    20881 ctcggcctcg tcggggaccg tggagacatg gatcttccag ccctgctcgg cgagtcgggt
    20941 gtgctcgggc accagggagg tccacaggcc cgcggccgac cggcgccagc cggcgggggg
    21001 cgggtcggtg tcgaggcggt agcgggagtc cgcgtcgggc agccggtccg gggtgtcgta
    21061 gtacgtgcgg tcggcgaggc agtagagctg ggtttcctgg acggctggca cgctcggctc
    21121 tctcttctcg aagggggcga aggcctctcg aagggggtcg ggaggggtca ggtcccgggg
    21181 gtggcgtgct tggccgcggg cgccaccggc tcggtcggct ccggctcgtg ggccggaggc
    21241 gccggttccg tacgggccga ggcggcgaag gtgaccacga gcgccgacac ggccaggacg
    21301 cacccggtca gggtgaaggc ccagcgggcg ccgaacgcca tcagcagcgc accaccggcc
    21361 agcggcccga acggctggac catggaggac aggaacccgg ccgcgctctg cacccggccc
    21421 accttctcct ccggggtcac caccagcagc ttcgacagga acccgatgct ggcgaccgtc
    21481 gacaggaaca tgcacagcgc gcacatcagc ccggccacca ggggccggct gagccacgcc
    21541 atcacgccgg cggcggccac acaggtccag caggtggcga cgatcagcac ccgggagtgc
    21601 cgggcgggtt tgatcctcgg cgcgaacagc gccccggcca gggccccggc ggagacacag
    21661 ctgatgacga agccgccgcc gatcccggag cggcctccgt cggagaaggc ggtcagcgcg
    21721 atgaaggtga gggagccgaa ggcgaagttc atgcccaggc cgaagatgag caggaccgtc
    21781 cgcaggtagg gaatctgcca caggaacgtg aggcctgccg tgagttcgcg cttgctgaac
    21841 gcggagcccg ccgccgtcct ggcccgcgag cgggtgcgta cgagagccac gcagacggtc
    21901 gacgcgagca ggccgagcgc ctcgacggcg aacggcagcg ccgggtggag gccgaagagc
    21961 gcacccccga cgagcggccc gaccagccgg gccgtctggg tgcgcgcctg gagccgtgcg
    22021 gtggcggtgc ccatctggtc ggccgggacg accgcgcgca tcaggccgaa gacggcgggc
    22081 gcgtagacgc tgctgatcac cgcacccgcc gcggcgacga gcaggacgag cgccatgggg
    22141 gcgtgcccgt acaggacggc gatggtcagg gcggtgacga cggtcaggct gccgacgtcg
    22201 cacagcctca tcagccggcg gcgttcgatg cggtccgcca tcaccccgcc gggcagcatg
    22261 gtgatcagga cggctcccac ggacaccgtc ccgacagcac cggcctgcac cggggagccg
    22321 gtctccttga ggaccagcag gggaagggcc agggcactca tctgcccgcc gaggaccgcg
    22381 aagaggccgc tcagccagag cagccggaag tcccggtttt cgcgtagcgg cttggtcatc
    22441 gtggtctccc ggtggtgggc gggggggtcg gtcggtggtc cgttcggcgg ggtggtgtcc
    22501 cgggggtggt gtccgggggt tccggggggt ggtgtccggg ggttcccggg ggtggtgtcc
    22561 ggggggggtg acttctcctg aggtgccgtt cgggtgggcg ggcgcgggcc ggaatcgacg
    22621 gcggggcggc tccgtcgtga cggaaccgcc ccacatcacc ggccggccgg gcgccacggc
    22681 ggggagagct gtctcagcct ccgtggcgcc gccccggtgc ggcccggtca gttctccatg
    22741 acgacgctga gcacgctgac gcagctgccc ggcgccacga ccttgtcgac ggacgtctcc
    22801 tggaggtcca gcacggagtg cgcctcgacc tcggcggact cgttctcgtt gttctcgtcg
    22861 gcggcgggct tcgtgttctc ggacatggtg gtctccgtcc actcgtcact gctggacccg
    22921 gaatccgtgg gatgcgtacc gcggtctccg gtgcggcggg ccggtgcctg ccgttgccga
    22981 gaaagttagg agcgccggcc tcgaagacgc ttcggcgccg gtatggcggc ggtatggggc
    23041 cagctcgccg gccgtggacc cgtgcgccgg gcccgcctgg cgggtccccg ccccctccct
    23101 gacctgcgcc cataccgtcg ccgaagcatc cgcagaccgc cggtgaaccg gtacgtcgca
    23161 gcctgggcgg gcgcgcaccg gcccctggag tacgggcgcg ccccggcccc gaaggaggcg
    23221 gcccgtatgg aactcgccga actcgtcgga ctgcggccct tcccggccgc cggtctgctg
    23281 ctcggcctca cccgccgctg ccccctgcgg tgcgggcact gctccaccgg gtcggacctg
    23341 accgtgcggg aggagccgga cgcggaccgg ctcctgcgtt tcgtcggctc gttcacctcc
    23401 gagaaccgcc cggacgtcgt catgctgacg ggcggggagc cgctgctcct gccgacgctc
    23461 gccggcgagc tgagcttcct cgcgcgccgc gccggatcgc gtacggcggt gctgagcggc
    23521 atgttcttcg cccgctccaa ggagatcccg cccgcgatcc tgcgcgcgat cgcccaggtc
    23581 gaccacttct ccgcgagcct ggacgtgcac catgagcggg aggtggcgcg cgccgacgtg
    23641 ttccgggcgc tgcaccgcat ccgcgagtcg ggtgtctccg tcagcttcca cctcacgggg
    23701 accggggcgg acgatccgta tctggccgac atcacccgcg ccatcgacca ggagttcggc
    23761 ggccgggtgc cgtcgctggt caacgaggtg cggccgttcg gccgggccgc ctcctgggcc
    23821 cggcccgcac gcggcggccc cgacccgtcg gcggcggcgc cgtgctccat ggccgcctgg
    23881 ccggtggtcg ccttcgacgg tacggtgctg gcctgctgca accaggacac ggtggaccgg
    23941 cgccccgccc ccgcccatct ggacctcggg cacatcggct ccgacgactg ggagacggta
    24001 cgccgacggg ccctggaatc accggtgttg cggatgatcc gcacggtcgg gcccgcccat
    24061 ctggccgccc gctcaggcgc cgcaccccgg ccgggctcct actgcgacgg ctgccgggcg
    24121 ctgggcgggg acgaggcggt ggcggccggg gcccgggcgg tggcggccgg accggcgggc
    24181 gcgctgctgg acctggccgc cgcgcagcgc ggtgcgctgg gcgggccgga gggggtcgtc
    24241 cggcggcacg gctgctcggc gtacgccccg ctggtcggag cccggggcgc ggggagcacc
    24301 cggtgagcat cacctggacg agcacctccg catcgaccgc cacagccgcg aacaccgcca
    24361 ccgcgaccgt ctcgacgcgc ctgcgcacca aactcctgct cctggaaccg gagttccgag
    24421 gcgccaccac ccatatgtgg cgcgctgagg ggctggtgga ccgctaccgg acctacctgt
    24481 ccaccatgca cgccgtgatc cgggcctccg taccgctgat ggaactggcc ctgtggcgcg
    24541 cctccgacga ccccggtgac ccgctgtcgg aaccgctgtc cgcctacctg gtggagcaca
    24601 tccgcgagga ggccgggcac gacgcctggc tgctggagga tctggtcgcg gcgggcgcga
    24661 cagccgggga cgcgcccggc ccgttgccac cgccggacgt ggccaccctc gtcggccccc
    24721 agttctactg gatcgagaac caccacccgg tgaccctgct cggctatatc gcggtgctgg
    24781 aggggtacgc ccccgccccc gggctgaccg accgcatcgc ttccctgacc gggctgcccg
    24841 ccgccgccct gcggaccgta cgggagcacg cggcactcga cacggaccat ctggacgagc
    24901 tgtacgcgct gctggaccgg ctgccgctga cccgggacca ggaagcggcc gtcgcggtca
    24961 gcgcgctgca ctccctcgac gcgctcaccc ggctgttcgt ccggctcggg cgctccgcac
    25021 cggcgccgtc gctgcgggga gccggaccca cctcaccgac gggagtcacc ccatgaccgg
    25081 accgccgcaa ccaccgccca ccgatcccga acagctgccc acggaagccg tgttgtacga
    25141 ggcggggttc cccgtggacc tcctcaccga ggagcagcgc caggtgctcg gcgagctgtc
    25201 accgcaggag ctgaccctgc tgctggacgt caagagccgg ctggacgcgg tgggccccga
    25261 ggtccaggcc cacggcgaga tcgcgggtgg cgcgctgttc taggggcttc cgtccggatc
    25321 ggcccgcgag cccggcctga tccggacgag aggcccggcc cgcgccgggg gcgcccgcgc
    25381 caggacgggg gtccggcgcg ggcgcccccg ggaccggatc agccaccgcc ccctcttccg
    25441 gggcgagttg gaccaggaga gttgaggacc cgccatgacc tgcccctcgt gccgacagga
    25501 gcttccctcc acggcccggt tctgctcgtc ctgcgggacg ccgtgcgccg gtccggccgc
    25561 tgccgccccc gcacccgtcc cgcctccggc cgaggacgaa cgcaagccgg tgaccgtgct
    25621 gttctgcgat ctggtgggct ccaccgccct gtccggggtg ctggacccgg agaccctgcg
    25681 cacggtgacc ctgcggtact tcgaggcgat gagcgcgcag atcgtggcgc gcggcggcac
    25741 cccggagaag ttcatcgggg acgcggtcat ggcggtgttc ggcgtgccgg tggtccgtga
    25801 ggacgacgcc cggcgggccc tggcggcggc gctcgggatg cgccgggcgc tggacgccct
    25861 caacgaggag ctggacgcct cgctcggcat ccggctcacc acccgggtcg gggtcaacac
    25921 cggtcaggtg gtggcgggtt cggatgccac cgcccggcag gccctggtct ccggggaggt
    25981 cgtcaacatc gccgcccgcc ttgagcagaa cgcgggtccc ggcgagatcc tcatcggccc
    26041 gcagaccctc ctcgccgccg gccccacggt gcaggccgag cccaccggcc cgctgcggct
    26101 caagggcaag cgggagagcg tgcaggcgta ccggctgctg gcgctcgggg cggacgaccc
    26161 cgagctgctg cgccgcttcg acgccccctt cgtcggccgc accaccgaac tggacgcgct
    26221 gagaagggcg ttggccgaga ccgtacaaga ggaccgcccg ggtctgctgc gggtgaccgg
    26281 cgaggcgggc atcggcaaga cccggctggt acgggagtgg ctgacgcgcc acggcggcgc
    26341 gggcgccttc gcgtacgggg cgggccgctg ccgcacctac ggggaccacg gcacgctggc
    26401 gcccctcgcc gacgccgtac gctcgctgct cccgcccgcc ctcgccgccg gggacgaggc
    26461 ggtcgacgac gcgatggccc tgctcaccgg gggtctgctc cgcgacggca cccccaacgc
    26521 gcccttcgag gacatgtgcg ccgcgctgac cgtcgtcctg acccggacgg gccgggagcg
    26581 gccggtggtc ctggtcctcg acgactggca tgcggcggcg cccctgctgg tccggacggt
    26641 ggaccggctg acgggcgcgg ccgggcccgc gcgcaccctg gtgatctgcg cgggccggcc
    26701 ggaggaggac cggggtgcgg gcgcggcggg cgggcggcgg gggcacctcc agctcaccgg
    26761 cctcccccgc gaggcggcgg cccggctcgc cgccggtctg gcacagctcg acggccgtcc
    26821 cgtccccgcc gacgaccggc tcctggcccg ctcggagggc aatccgctct atctggagca
    26881 gctgctcgtc ggcgaccggg ccgccgcccc gactccggaa ggggagcttc cgcccaccct
    26941 ccaggccctg ctgggggccc ggatcggggc gctggcccgg gccgagcgcg gggtggtgga
    27001 cctggccgcc gtgatcggcc gggagttcgc ggcggcggag ctggtgcggc tggagctggc
    27061 ggtacggacg gcggagcggc cggacgcccc cggcccccgg gatctcggcg gcgtcgacga
    27121 ggcgctcgcc gcgctggccc ggcggcggct ggtggagccc gcgccctccg gggccgggga
    27181 gtcgtcggcg taccgcttca gcagtggtct ggtgcacgag gtcgcctacg cctcgctctc
    27241 caagcgggcc aaggcggagc gccacgcgtg ggcggccgag ctgccgagcg tggagcggac
    27301 cggggacggc gcggtcggcg gccatctgga gcgcgcctac cgctaccgcg ccgagctggg
    27361 gctgctggac gaccgggccc gggcgctgcg ggaccgcgcc gccgccgcgc tcggccgggc
    27421 cggggcgcag gccgccgccc ggtccgacct gcactgggcg cacgggctgc tggagcgggc
    27481 ggtggagctg cggccggagg cggcgcgggc ggtgctgggg ctcggtgagg tacgggtggc
    27541 gctcggccgg accgaggagg gtgccgaact gctgcgcacg gtcagggact tggccaccac
    27601 ccccgtggag tccgcgcacg cccgcctggc gctggcggtg ctggacccgg cggcgagccc
    27661 tggccccgcc gccacggccc gggcggtgct gccggtcttc gaggcggccg gggacgcgat
    27721 cggccgggcc cgcgcccatc tccgcctcgc ccagcagctc cagcagtcgg gccgccacga
    27781 ggaggcggag cgcgaccacg cgcgggccct ggagcacgcg gtggcggccg gggcggagcc
    27841 ggagcgggcc ggggcgctgg gcgcgatcgg gatctcactc tggcgcgggc ccgtcccggt
    27901 gccggaggcg gtggagcggt gccgcgccct gctggcggcg cacggttcgg gccggccgac
    27961 ggtccgggtg acgctcaact gcccgctggc cgtgctgtac gggctccagg accggcccga
    28021 cgaggcgtac gcctgcctgg ccgaggccga acggctggcc gggaagctgg ggttcgcgga
    28081 ggcggaggtc ttcctgccgg tgttccgggc gacggtggag gcgctgctcg gccgggacgc
    28141 ggaggccctg gagctgctgg ccagggcgga cacggcggcc cggcgcatgg gggccgcggg
    28201 gatgcggacg gcgctcgcgc tggacgcggc ccggctggag ctggacgcgg gccgggccga
    28261 ccgggcggtg gagtggctgg cgggcatcgg tggcgcgtcg gggctgagcc gcgcggacgc
    28321 cgtcgacctg gaggggttgc gggcccggct ggcggccccg gaccgcccgg acgaggcgct
    28381 gcaccacgcc gacagggccg tacgcgcatc cctgctcacc gactcaccgc tggtccaggc
    28441 ctccgccgaa ctggaccggg cccgcacgct cgccgcgctg caccgcacgg ccgacgcggt
    28501 ggcggcggcc cggagcgccg gggagcactt cgcgcacaag ggccacctgc cggggacccg
    28561 ccgggtggcg gccttcctcg gagcgcagac aggacccccg gccatggcca cgacgagcac
    28621 gacgagggaa gggagctgac cgatgggcac cacggaagcg acggcgacag ccgggacgag
    28681 ggccgcgccc gggcagggcc tcacctggag tctgcgcggg cgcggccccg aggacgtgcc
    28741 ggtactgggc gatccggggc cgccgggcgg gcagcccgcc gggcccgccc tggggcgcgg
    28801 cgtccgcgtc tgcgtggtgg actcgggggt ggagcgcgac catccgctgg tcggcgaacc
    28861 ggccgcctcc tgggtggtcg tcaaggacgc ggagagcggc gagatcacgg tggaaccgac
    28921 gaccaccggc gatacctgcg gccacggcac cgcgtgcgcg ggcatcatcc gccggaccgc
    28981 gccggagtgc gagatccaca gcgtacgggt gctgggtgag cggttctccg ggaccgggga
    29041 catcctgatg gcggggctgc ggtgggcggt ggagcagcgg ttcgacgtgg tgaacctgag
    29101 cctgtcgacg acccgcaccc ggttcgcgca ggagctgcac tccctcgcgg actccgccta
    29161 cttcgcccgt acggtgatcg tcgcctcggc ccacaacacc ccggtggaga gcttcccgtg
    29221 gcggttcgcc tcggtgatct ccgtcggcag ccaccaggag gacgaccccg acctccacct
    29281 ctacaaccca cagccgcccg tggagttctt cgggccgggc cagaacgtca ccgtgccgtg
    29341 gctgggcggc cggacgatcc gcaccaccgg gaacagcttc gccacgccgt acgtcgccgg
    29401 gctctgcgca cgcatcctct cggcgcaccc ccggatgacg gccttccagc tcaagaacgc
    29461 cctttatctg tcggcggcca acgtgcggca cgagcccgcc gccgcacacc cgcgtccctc
    29521 aacagcggca ggagataccc gcgatgactc cgaagactga atccgccccc gcccccttca
    29581 ctcctgccga cgcgccccgc ggcgaactgc tccagtcggt cgtcgacgtg gcccgggcca
    29641 tcttcggcgc tgcggccagc tcggtcctcc tgctggacga ggaggcggac gagctggtgt
    29701 tccaggcggt gtccggggag ggccaggagt tcctggtggg ccgccggttc ccggccgggc
    29761 gcggcatcgc cggctgggtg gcgacctccg gcgagccgat ggtggtggac gacctggccg
    29821 acgacccgtc cttcgaccgc tcactggcgg agtcgacggc gtacgtcccg aactccctga
    29881 tggcggcccc gctgatcagc gacgcgcgcg tcctcggcgt cctggaggtg ctggacgcgt
    29941 caccgcaggc ccggagcagc gtgcgggagc tggacctgct ggcgatgttc gcccggcagg
    30001 cggcggcggc cctgcgggtg atcaccccgg agccggtggc ggtctccgcc ggtcgggtgc
    30061 tggacggcgc ggagcgcgag gacgcgctgc ggctgctcgg tagcctggag caggtgctgc
    30121 ggggcaccgc ataggggccc gcacggtggg caggagccgg gagaaggcgc cggacccgct
    30181 cccgcgcggc cacgatggaa ggacaggcac gtgaagctcg ctttctccac tctcggggtg
    30241 ccggggatgc cggtggccga ggtcgtacgg ctcgccgccg agcacggtta ccggggcgtg
    30301 gagctgcgcg cccaccccga ggagcccgtg cacctgggcc tctcctccct cgaacgggcc
    30361 gatgtcgtcg aggtgttcaa ggcggccggg gtggagatcc tgaccgtggc cgggtacgtc
    30421 caggtggcct ccgagggcga cgacgaggcg atctccgccg aactggccga gctggtgaag
    30481 ctcgcccggg acctgggcgc ccgctacgtc cgcgtcttcc ccggcggcgg cgaccaggac
    30541 ccggcggacg ccgacgcgac ggccgcccgc cgcctgggtt ccgccgcccc ggccgccgcc
    30601 gacataggcg tcaccatcct gctggagacc cacgacacgc accgcgcggg cgccgacgtg
    30661 gcccggatcg tgggcaccgt cggccacccc aggatcggcg ccatctggga tgtcctgcac
    30721 acctggctgt ccggcgagga ccccaccgcg agccacgcgg tgctggcccc gcacctcggc
    30781 tacgtacagg tgaaggacgt cgcatcggcg gacgacctca ccccgctgcc cctgggcgcg
    30841 ggggtgctgc cgctggccgc ctgcctggag ccgctgggcc cggagacatg ggtgtgctgg
    30901 gagtacgaga agcgctggca cccggacgcg gcggacctcc cggggctgct gggcgcgggc
    30961 cgggagcatc tgctgcgggt gggggcaccg aaggggtagg ggccgcgagc ggcggctgcg
    31021 aagcggtagg gcgtacggag ccgggcgccg caggggtgac ggcccggcgc ccgcctgtcg
    31081 gcctggtcag cgccaccccg ccgaccagca g
//
