LOCUS       NZ_CP032543            10399 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1392266
            Orig. end                         :: 1402665
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="7"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    325..341
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.06"
                     /tool="antismash"
     gene            complement(347..1459)
                     /locus_tag="D6270_RS06470"
     CDS             complement(347..1459)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607776.1"
                     /locus_tag="D6270_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_109166310.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2e-16, bitscore:
                     58.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDQVRDQDGQRVLRVRGRVLVGPDEVRDELWAVGGRITYERPPG
                     ADRAETVTGWVLPGLVDAHCHVGLDRHGPVDAATAEKQALTDREAGTLLIRDAGSPSDT
                     RWIDDRDDLPKIIRAGRHIARTRRYIRNYAHEIEPGDLVAYVAREARRGDGWVKLVGDW
                     IDRDAGDLTACWPRGEVEAAIAEAHRLGARVTAHCFAEAALRDLVEAGIDCVEHATGLT
                     EETVPLFAERGVAIVPTLVNIATFPDLAAGGEAKFPRWSAHMRQLYERRYDTVRAAYDA
                     GIPVYVGTDAGGSLAHGLVAGEVAELVKAGIPPLEALSATAWGARSWLGRPGLEEGAPA
                     DLVVYDEDPRADVRVLAAPRHIVLNGRVTG"
     gene            1536..2642
                     /locus_tag="D6270_RS06475"
     CDS             1536..2642
                     /NRPS_PKS="Domain: Aminotran_5 (15-271). E-value: 3.4e-28.
                     Score: 90.5. Matches aSDomain:
                     nrpspksdomains_D6270_RS06475_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957694.1"
                     /locus_tag="D6270_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_109166309.1"
                     /sec_met_domain="Aminotran_5 (E-value: 3.4e-22, bitscore:
                     77.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTAAHFAAIERRVAALLATEQDVVITQGEALLPLE
                     GCIRSGARPGSTALNVVTGPYGQTFGNWLRDCGARVVDLTVPFHTAVSAAQIAEALAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVAAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWERIAANPAAPRRSYLSLLDWRERWIDAGRKALPHAP
                     AQLEMLGLEACLERIEEDGLDEVMARHASAAAATRVGAVALGGGLEPYVLQARDAAPVA
                     TTLRTPAGTDASALVARALELEPTLPLVAGGGALSKEMIRVNHYGADATRNAVLSSLGA
                     LGAALAATGRQVDFEAARRAVTETSPGL"
     aSDomain        1581..2348
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS06475_Aminotran_5.1"
                     /evalue="3.40E-28"
                     /label="D6270_RS06475_Aminotran_5.1"
                     /locus_tag="D6270_RS06475"
                     /protein_end="271"
                     /protein_start="15"
                     /score="90.5"
                     /tool="antismash"
                     /translation="FAAIERRVAALLATEQDVVITQGEALLPLEGCIRSGARPGSTALN
                     VVTGPYGQTFGNWLRDCGARVVDLTVPFHTAVSAAQIAEALAEHPEIDFVSLVHAEAAT
                     GNTNPVAEIGEVVRAHGALFMLDAVASVAAEPLLPDAWGVDLCVIGAQKAMGGPAGVSA
                     VSVSERAWERIAANPAAPRRSYLSLLDWRERWIDAGRKALPHAPAQLEMLGLEACLERI
                     EEDGLDEVMARHASAAAATRVGAVALGGGLEPYV"
     misc_feature    2767..2784
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    complement(2769..2784)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2779..2794
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2913..2925
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(2925..2939)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            2950..3480
                     /gene="ectA"
                     /locus_tag="D6270_RS06480"
     CDS             2950..3480
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123622.1"
                     /locus_tag="D6270_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_109166308.1"
                     /transl_table=11
                     /translation="MTAAPADFARARSEFLSIDTPRVEDGAAIWRIARDSQVLDLNSSY
                     SYLLWCRDFAATSAVARGEDGEPIAFVTGYIRPDRPEALVVWQVAVDQAHRGKGLAATL
                     LDALTARVAADQGLSCVETTITPDNTASDRLFTSYAQRHDVALEQEVLFDGGLFPEGTH
                     LPEVLYRIGPFAG"
     gene            3654..4916
                     /gene="ectB"
                     /locus_tag="D6270_RS06485"
     CDS             3654..4916
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-363). E-value: 6.5e-72.
                     Score: 234.3. Matches aSDomain:
                     nrpspksdomains_D6270_RS06485_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="D6270_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_109166307.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4e-77, bitscore:
                     258.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHTY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFEGTVPDFLWFERLLDDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRALKELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALQAYWADGQMEKQTLARGEQVEQALL
                     AICAEEPTAQFRGRGLVWGMEFEDPARASAVCARAFELGLLLETSGPQSEVVKLLPPLT
                     VTTEELDEGLRTLARCVRETA"
     aSDomain        3738..4742
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS06485_Aminotran_3.1"
                     /evalue="6.50E-72"
                     /label="D6270_RS06485_Aminotran_3.1"
                     /locus_tag="D6270_RS06485"
                     /protein_end="363"
                     /protein_start="28"
                     /score="234.3"
                     /tool="antismash"
                     /translation="FDRAQGARLTDEDGHTYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFEGTVPDFLWFER
                     LLDDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALKELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALQAYWADGQMEKQTLARGEQVEQALLAICAEEPTAQFRGRGLVWGMEFE"
     gene            5001..5399
                     /locus_tag="D6270_RS06490"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045195.1"
                     /locus_tag="D6270_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_018512207.1"
                     /sec_met_domain="ectoine_synt (E-value: 7.3e-54, bitscore:
                     179.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIENTDRHVKSASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNDETGETHWISPGTMYLLDGHERHTLRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEA"
     gene            5405..6298
                     /gene="thpD"
                     /locus_tag="D6270_RS06495"
     CDS             5405..6298
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="D6270_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_109166306.1"
                     /sec_met_domain="PhyH (E-value: 7.7e-37, bitscore: 126.1,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIAAKDLQGY
                     EHDGFLTVDQLITPDEVAVYRAELDRLVADPLIRADERSIVEKQSQNVRSVFEVHKISE
                     VFAGLVRDERVVGRARQILGTDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENFDTNGGLMIMPGSHKTFLGCAGETPKDNYKKSLQMQDAGTPSDEALT
                     KMADRHGIRLFTGQAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENEAQEPFAAP
                     IRRPDFIGARDFTPVK"
     gene            6401..7435
                     /locus_tag="D6270_RS06500"
     CDS             6401..7435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070337.1"
                     /locus_tag="D6270_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_109166305.1"
                     /transl_table=11
                     /translation="MTSHVRHITVDCADAYALGSFWSQVLGAPLAADDFPGDPEALLET
                     PGAAILFVQGPDTKTAKNRVHLDVQPQDRTRDEEVERLLALGATLVGDHRRADGRGWAT
                     LADPEGNEFCVERSAAERAAPGGTRPPVTADDVTTAVRLAVDTLAGAPADGWDGAAGTL
                     EWTCWETVEHLSDDLFAYAVQLGPRTPPVDGEVPYRWVPDRRGGPANAVFADRAAGPAG
                     LLATLEASGALLASMARTTPPEVRSYHGYGISDPEGFAAMGVVETLVHTYDLAEGLGLT
                     WAPPAALCDRALARLFPGAPAGGDRWTVLLWATGRAELPGRPRRTEWRWDGRPLEDQTA
                     SSAG"
     gene            complement(7411..8481)
                     /locus_tag="D6270_RS06505"
     CDS             complement(7411..8481)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="D6270_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_109166304.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLSGTPLANRIVMAPMTRSRAGEGGTATELTAAYYAQ
                     RASAGLVITEGIQPSVVGQGYPFTPGLHSAEQVASWRKVTDAVHAEGGRIFAQIMHAGR
                     IGHPVLLPEGLTPVGPSPVKAEGQVYTHEGPKDFVVPHELTDAEIRQTIADFVSASRNA
                     IEAGFDGVELHGANGYLIHQFLAPNTNLRTDGWGGSETGRIRFAVEVVKAVAAEIGAAR
                     TGLRISPSNVYNDIDEPAPDAVYTALVQEIEPLGLAYLHILEGAPIRELTLSLRKVFTG
                     TLLINVHSDGPTGPDDHTVIDDGIADLISYGVLFLANPDLPARLKAGGPFNTPDPASFF
                     GGDAKGYTDYPALDAV"
     gene            8650..9156
                     /locus_tag="D6270_RS06510"
     CDS             8650..9156
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607784.1"
                     /locus_tag="D6270_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_109166303.1"
                     /transl_table=11
                     /translation="MNTAPAGTAEAACTDALPGAALSGPVSHAVSRVARLHRIAAGKLL
                     KGLGLYPGQELLMMQLWDSGPVRQAELIKTLDLDPSTVTKMLQRLEQTGHVRRRPDPDD
                     RRAVLVEATDESCALHTAVRDAWGSLEEHTLAGLASDERTELTRLLAKVEANLCHETEG
                     CPERG"
     gene            complement(9187..10245)
                     /locus_tag="D6270_RS06515"
     CDS             complement(9187..10245)
                     /NRPS_PKS="Domain: Aminotran_5 (19-347). E-value: 4.4e-23.
                     Score: 73.7. Matches aSDomain:
                     nrpspksdomains_D6270_RS06515_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512202.1"
                     /locus_tag="D6270_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_109166302.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-16, bitscore:
                     58.1, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 8.5e-09, bitscore:
                     33.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSPLRQVAAAEFAPEVTYLNTSSWGLLPRRTIAAVKALADENA
                     AGRRIGAGSFDVVEAARAGFARLAGVRPERVATGSSVTVHVGLIAASLPAGAEVLAPEG
                     EFSSVVSPFALRGDLRMRYVPLADLADAVRPTTALVAFSSVQSADGRVADLAAVRAAAA
                     AHGARTLLDATQSAGWFPLDAGAYDYTVTGGFKYLLCPRGTSFLTVTEEAQATLPHLFA
                     GWVAAGAPWTGNYGPLERVAPGARGFDEPPAFLSYHGAEHSLALLAEVGIDALYAHATS
                     LAARLRSGLVELGHEVVPGESAIVSVPGLDGRHDELTRAGIAVSAPAGNLRISCHLYNT
                     GADVDRVLDVLG"
     aSDomain        complement(9205..10188)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS06515_Aminotran_5.1"
                     /evalue="4.40E-23"
                     /label="D6270_RS06515_Aminotran_5.1"
                     /locus_tag="D6270_RS06515"
                     /protein_end="347"
                     /protein_start="19"
                     /score="73.7"
                     /tool="antismash"
                     /translation="YLNTSSWGLLPRRTIAAVKALADENAAGRRIGAGSFDVVEAARAG
                     FARLAGVRPERVATGSSVTVHVGLIAASLPAGAEVLAPEGEFSSVVSPFALRGDLRMRY
                     VPLADLADAVRPTTALVAFSSVQSADGRVADLAAVRAAAAAHGARTLLDATQSAGWFPL
                     DAGAYDYTVTGGFKYLLCPRGTSFLTVTEEAQATLPHLFAGWVAAGAPWTGNYGPLERV
                     APGARGFDEPPAFLSYHGAEHSLALLAEVGIDALYAHATSLAARLRSGLVELGHEVVPG
                     ESAIVSVPGLDGRHDELTRAGIAVSAPAGNLRISCHLYNTGADVDRV"
ORIGIN
        1 gcggcgaccg ccagggcggc gaggcggaag gtgttgctgt tcaagatggt ggaaccccca
       61 caagagacat ggagccaccg gcgcagtcca atgggggaca tcgcctgtgc cggtggcctc
      121 gactccgtga atctttacgc actgtgggtg aactggcgga cacctggcgt gagttcaccc
      181 caaagggggg tttccgcgcg catattcgaa tctttcggca cgcgcgttcc ctctcacccc
      241 tccacatcac ccgtttcaca tgtcaggagc cgggcgcagc gatgagccgg accatctcaa
      301 cgagccgggg gcggcatccg tcactgcctg tcaacccggc accacctcag ccggtgaccc
      361 gcccgttcag cacgatgtgg cgcggggccg ccagcacccg gacatccgcg cgcgggtcct
      421 cgtcgtacac gaccaggtcc gccggagccc cttcctcgag ccccggccgc cccagccagc
      481 tcctcgcccc ccacgcggtg gcggagagcg cctccagcgg cgggatgccc gccttcacca
      541 gctcggcgac ctcgcccgcg accaggccgt gcgccagcga gccgcccgcg tcggtgccga
      601 cgtagaccgg gatgcccgcg tcgtacgcgg cccgcacggt gtcgtagcgg cgctcgtaca
      661 gctgccgcat atgggccgac cagcggggga acttggcctc gccgcccgcc gcgaggtccg
      721 ggaacgtggc gatgttgacc agcgtcggga cgatcgcgac accgcgctcg gcgaagagcg
      781 ggacggtctc ctcggtgagg ccggtggcgt gttcgacgca gtcgatgccc gcctccacca
      841 gatcgcgcag cgccgcctcg gcgaagcagt gcgcggtgac ccgggcgccc agccggtgcg
      901 cctcggcgat ggccgcctcg acctcgccgc gcggccagca ggcggtcagg tcgcccgcgt
      961 cccggtcgat ccagtccccc accagcttga cccagccgtc gccgcgccgg gcctcccggg
     1021 cgacgtacgc gacgaggtcg ccgggctcga tctcatgggc gtagttgcgg atgtagcggc
     1081 gggtcctggc gatgtggcgg cccgccctga tgatcttcgg caggtcatcg cgatcgtcga
     1141 tccagcgggt gtcggagggc gatccggcgt cccggatgag cagggtcccg gcctcccggt
     1201 cggtgagcgc ctgcttctcg gcggtcgccg cgtcgaccgg gccgtgccgg tccagcccca
     1261 catggcagtg cgcgtcgacg aggccgggca gcacccagcc ggtgaccgtc tccgcgcggt
     1321 ccgcgcccgg cggccgctcg taggtgatcc gcccgccgac ggcccacagt tcgtcgcgta
     1381 cctcgtccgg gccgacgagg acccgtcccc tcacccgcag cacccgctgc ccgtcctgat
     1441 cgcgcacctg atcactcata ggcggcactg tacgaggccc tcggtaggct gctggagcct
     1501 gtcgaccgcc gaccgaaccc gaagagagcc ccaccgtgac acaccccttc ctcgacctcc
     1561 ccccgctgac cgccgcgcac ttcgcggcca tcgagaggcg ggtggccgcg ctcctcgcca
     1621 ccgagcagga cgtcgtcatc acacagggcg aggcgctgct gccgctggag ggctgcatcc
     1681 gtagcggcgc ccggcccggt tcgaccgcgc tgaacgtggt caccggaccg tacgggcaga
     1741 ccttcggcaa ctggctgcgg gactgcggcg cccgggtcgt cgacctcacc gtgcccttcc
     1801 acaccgccgt gagtgccgcc cagatcgccg aggcgctcgc cgagcacccg gagatcgact
     1861 tcgtctccct ggtgcacgcg gaggcggcga ccggcaacac caacccggtc gcggagatcg
     1921 gcgaggtggt ccgggcgcac ggggcgctgt tcatgctgga cgcggtcgcc tcggtggccg
     1981 ccgagccgct gctgccggac gcctggggcg tcgacctgtg cgtgatcgga gcgcagaagg
     2041 cgatgggcgg tccggccggg gtgtcggcgg tctcggtgag cgagcgggcc tgggagcgga
     2101 tcgccgccaa cccggccgcc ccgcgccgct cgtacctctc gctgctggac tggagggagc
     2161 gctggatcga cgcgggccgc aaggccctgc cgcacgctcc ggcgcagctg gagatgctgg
     2221 gtctggaggc gtgcctggag cggatcgagg aggacggcct ggacgaggtg atggcccgcc
     2281 acgcctcggc cgcggcggcg acccgggtgg gtgcggtggc gctgggcggc ggtctggagc
     2341 cgtacgtcct tcaggcgcgg gacgccgctc cggtggccac cacgctgcgc accccggcgg
     2401 gaaccgacgc gtcggcgctg gtcgcgcggg cgctggagct ggagcccacg ctgccgctcg
     2461 tcgcgggcgg cggggctctc tccaaggaga tgatccgggt caatcactac ggtgcggacg
     2521 cgacgcggaa cgcggtgctg tcctcgctcg gggctctggg ggcggcgctg gccgccacgg
     2581 gccggcaggt cgacttcgag gctgcccgtc gtgcggtgac ggaaacctcc ccgggcctct
     2641 gatattcata atgcggggag ctactttatc gaaattagct ccccgcattc ttctgcccgc
     2701 tttccatcct gctaaacgcg gaagtttttc ggggtccgaa cttcatgatt cggacacgtc
     2761 tcagaggagt tacaaccctg tgaccgactc cacaagagcg gcgttatgcc cgaaaaattc
     2821 ggcacaaaga gtgcgaaatc gtaccggggt tcggtcgaat ctcgcgcacg cctgataaca
     2881 catgaaggcg ccctacccaa ccctttgcct cgatgcaatt tagaaatttg ctgggtaaat
     2941 tcaattcgca tgaccgccgc accagcagat tttgcccgtg cccgaagtga attcctgagt
     3001 atcgacacgc cacgagtgga ggacggagcc gcgatctggc gcatcgcccg cgactcccag
     3061 gttctggacc tgaactcctc gtacagctac ctgctgtggt gtcgcgactt cgccgcgacg
     3121 tccgccgtcg cccgtggcga ggacggtgag ccgatcgcct tcgtcaccgg ctacatcagg
     3181 cccgaccgcc ccgaggccct cgtcgtctgg caggtggccg tcgaccaggc gcatcgcggc
     3241 aagggactgg ccgccaccct gctggacgcg ctgaccgccc gggtcgccgc cgaccagggg
     3301 ctctcctgcg tcgagacgac gatcaccccg gacaacaccg cgtccgaccg gctgttcacg
     3361 tcctacgccc agcggcacga cgtcgccctg gagcaggagg tcctcttcga cggggggctg
     3421 ttccccgagg ggacgcacct gccggaggtc ctctaccgga taggcccgtt cgccggctga
     3481 ggcagccgcg tcacctgatc cgcccgttca cggcccggcg tacctgaccc gtacgcccgg
     3541 tcccccacga cttttcgcgc cggccgacca tccggcgcgg tcccggccgc cctggtgcgg
     3601 cggggagcac cgaccacatc gcccgtcaca ccccctcacg caggagaccc gctgtgacca
     3661 tcaccccgcc cgcactgagc gtcttcgaga ccctggagtc ggaggtccgc agctactgcc
     3721 gcggctggcc ggccgtcttc gaccgcgcgc agggcgcccg gctgaccgac gaggacggcc
     3781 acacctacct ggacttcttc gccggggccg gctcgctcaa ctacggccac aacaacccgg
     3841 tgctgaaacg agcgctgatc gactacatcg agcgcgacgg catcacccac ggcctggaca
     3901 tggcgaccac cgccaagcgc gccttcctgg agacgttcca gaacgtcatc ctgcgcccgc
     3961 gcgacctccc gtacaaggtc atgttccccg gcccgacggg caccaacgcc gtcgagtcgg
     4021 cgctgaagct ggcccgtaag gtcaagggcc gcgagtcggt cgtctcgttc accaacgcct
     4081 tccacggcat gtcgctgggc tcgctcgccg tcaccggcaa cgcgttcaag cgggccggcg
     4141 ccggcatccc gctggtgcac ggcaccccga tgccgttcga caactacttc gagggcaccg
     4201 tccccgactt cctctggttc gagcggctcc tcgatgacca gggctccggg ctcaacaagc
     4261 ccgccgccgt gatcgtggag acggtccagg gcgagggcgg tatcaacgtg gcccgcgccg
     4321 agtggctgcg cgcgctcaag gagctgtgcg agcgccagga catgctgctg atcgtggacg
     4381 acatccagat gggctgcggc cgtaccggcg gcttcttctc cttcgaggag gccggcatcg
     4441 tcccggacat cgtcacgctg tcgaagtcca tcagcggtta cgggctgccc atgtcgctct
     4501 gcctgttcaa gcctgagctg gacatctggg agccgggcga gcacaacggc accttccgcg
     4561 gcaacaaccc ggccttcgtg acggccgcgg ccgcgctgca ggcgtactgg gccgacggtc
     4621 agatggagaa gcagaccctg gcccgcggcg agcaggtgga gcaggcgctg ctggccatct
     4681 gcgccgagga gccgaccgcg cagttccgcg gccgcggcct ggtctggggc atggagttcg
     4741 aggacccggc ccgcgcctcg gcggtctgcg cccgcgcctt cgagctggga ctcctgctgg
     4801 agacctccgg cccgcagagc gaggtcgtca agctgctgcc gccgctgacc gtcaccaccg
     4861 aggaactgga cgaggggctg cgcacgctgg cccgctgcgt ccgcgagacg gcctgacccg
     4921 gcgagtccgg ggcaggcgga gaaagagcgc cccgggcccg cgggcccggg gcggagttca
     4981 agagaaaggc actgctcacc gtgatcgtcc gatcgttcaa ggacatcgag aacaccgacc
     5041 ggcatgtgaa gtccgcgtcc ggcacctggg agagcaagcg catcgtgctc gccaaggaga
     5101 aggtgggctt ctcgctccac gagaccgtgc tctacgcggg caccgagacc tccatgtggt
     5161 acgcgaacca catcgaggcg gtcctgtgca ccgagggcga ggccgagctc accaacgacg
     5221 agacgggcga gacccactgg atctccccgg gcacgatgta cctgctggac ggccatgagc
     5281 ggcacaccct gcggcccaag accgacttcc gctgcgtgtg cgtcttcaac ccgcccgtca
     5341 ccggacggga ggaccatgac gagaacggtg tctacccact gctgaccgag gaggcctgaa
     5401 ccgtatgacc accgaagtac gcgccgatct gtacccctcg cgcggcgccg ccgagatgac
     5461 cactccccgc caggacccgg tcatctggtc cgcgccgggc gcaccgggcc cgatcgccgc
     5521 caaggacctc cagggatacg agcacgacgg cttcctcacc gtcgaccagc tgatcacccc
     5581 cgacgaggtc gccgtctacc gggcggagct ggaccggctg gtcgccgacc cgctgatccg
     5641 tgccgacgag cgctccatcg tggagaagca gtcgcagaac gtgcggtccg tcttcgaggt
     5701 ccacaagatc agcgaggtct tcgccgggct ggtccgcgac gagcgggtgg tgggccgcgc
     5761 ccgccagatc ctgggcacgg acgtatacgt ccaccagtcc cgtatcaatg tgaagccggg
     5821 cttcggcgcc tcgggcttct actggcactc ggacttcgag acgtggcacg ccgaggacgg
     5881 gctgcccaac atgcggaccg tctccgtgtc gatcgcgctc accgagaact tcgacaccaa
     5941 cggcgggctg atgatcatgc ccggttcgca caagacgttc ctcggctgtg cgggcgagac
     6001 gccgaaggac aactacaaga agtcgctcca gatgcaggac gccggcaccc cgtccgacga
     6061 ggcgctgacg aagatggccg accgccacgg catcaggctc ttcacgggcc aggccggctc
     6121 ggcgacctgg ttcgactgca acgcgatgca cgggtcgggc gacaacatca ccccgtacgc
     6181 gcgctccaac gtcttcatcg tcttcaacag cgtggagaac gaggcgcagg agccgttcgc
     6241 ggcgccgatc cgccgccccg acttcatcgg ggcacgggac ttcaccccgg tgaagtagcg
     6301 gcatccgccc gcgtgatggg cccgggacgg tacgccgtcc cgggcccatc acgcgtaacc
     6361 cactggaccc cgccgccggc cgcgggccag ggtggcggcc atgacttctc acgtacggca
     6421 catcaccgtc gactgcgccg acgcctacgc gctcggcagc ttctggtccc aggtgctcgg
     6481 cgccccgctg gccgccgacg acttccccgg cgatcccgag gccctgctcg agaccccggg
     6541 cgcggcgatc ctcttcgtgc agggccccga cacgaagacc gccaagaacc gcgtccacct
     6601 ggacgtccag ccgcaggacc gcactcggga cgaggaggtg gagcggctgc tcgcgctcgg
     6661 ggccacgctg gtgggcgacc accggagagc ggacgggcgg gggtgggcga ccctggcgga
     6721 ccccgagggc aacgagttct gtgtggagcg ttccgccgcc gagcgggccg cgccgggcgg
     6781 gacccggccg ccggtgaccg ccgacgatgt gacgaccgcc gtgcggctcg cggtggacac
     6841 gctggccggg gctccggcgg acggctggga cggggctgcc gggacgctgg agtggacctg
     6901 ctgggagacg gtggagcacc tgagtgacga cctgttcgcg tacgccgtcc agttgggccc
     6961 gcgcacgccc ccggtggacg gtgaggtgcc ctaccggtgg gtccccgacc ggcggggcgg
     7021 cccggccaac gcggtcttcg ccgaccgcgc ggccgggccc gccgggctgc tggcgaccct
     7081 ggaggcgagc ggtgcgctgc tggcgtcgat ggcgcggacg actccgccgg aggtgcgctc
     7141 gtaccacggg tacgggatct ccgacccgga gggcttcgcc gcgatggggg tggtggagac
     7201 gctggtgcac acgtatgacc tcgcggaggg gctgggcctc acgtgggcgc cgcccgccgc
     7261 gctctgcgac cgggcgctgg cccggctctt ccccggcgcc ccggcgggcg gcgaccggtg
     7321 gaccgtcctg ctctgggcca ccggccgcgc cgaactgccg ggccgcccgc gccgcacgga
     7381 gtggcggtgg gacgggcggc ccctggagga tcagacggcg tcgagcgccg ggtagtcggt
     7441 gtagcccttg gcgtcgccgc cgaagaagga cgccgggtcg ggggtgttga aggggccccc
     7501 ggccttgagc cgggcgggca ggtccgggtt ggcgaggaag agcacgccgt acgagatgag
     7561 gtcggcgatc ccgtcgtcga tcacggtgtg gtcgtccggc ccggtcggcc cgtcggagtg
     7621 cacgttgatg aggagggtgc cggtgaacac cttgcgcagg gagagggtca gctcgcggat
     7681 cggggcgccc tccaggatgt gcaggtaggc gaggccgagc ggttcgatct cctggaccag
     7741 cgcggtgtag acggcgtccg gggcgggctc gtcgatgtcg ttgtagacgt tcgacggcga
     7801 gatgcgcagc ccggtacgtg cggcgccgat ctcggccgcg accgccttga cgacctccac
     7861 ggcgaaccgg atgcggccgg tctccgagcc gccccacccg tcggtgcgca gattggtgtt
     7921 gggcgccagg aactggtgga tgaggtagcc gttggccccg tgcagctcca cgccgtcgaa
     7981 cccggcctcg atggcgttgc gggaggcgga gacgaagtcg gcgatggtct gccggatctc
     8041 ggcgtcggtc agctcgtgcg gcaccacgaa gtccttgggg ccctcgtggg tgtagacctg
     8101 cccctcggcc ttgaccggcg aggggccgac cggggtcagt ccttcgggga gcaggaccgg
     8161 gtggccgatg cggcccgcgt gcatgatctg ggcgaagatc cggccgccct cggcgtgcac
     8221 cgcgtcggtg accttgcgcc aggaggcgac ctgctcggcg ctgtgcagtc ccggtgtgaa
     8281 ggggtagccc tggccgacga cggagggctg gatgccctcg gtgatgacga ggcccgccga
     8341 ggcgcgctgg gcgtagtagg cggccgtgag ctcggtggcc gtaccgccct cgcccgcccg
     8401 gctccgggtc atcggggcca tcacgatgcg gttggccagc ggggtgccgg acaggtcgat
     8461 cgggtcgaaa gcggtggtca taagggctcc caaaagtatg tggtcgacca atcgaagggg
     8521 tatgtggtcg gccaaccatt gacaccgacc gccactgtag ctcattactt ggccgaccaa
     8581 ggtaaagtgg gggaaaggac tgccgggcat gatcgaagcc ctaccggagc agcaccgagg
     8641 agccccgaca tgaacaccgc ccccgccggc accgcggaag ccgcctgtac cgacgcgctg
     8701 cccggagcag cgctcagcgg ccctgtgagc catgccgtat cccgggtcgc ccgactgcac
     8761 cggatcgcgg cggggaagct gctgaagggc ctggggctct acccgggcca ggagctgctg
     8821 atgatgcagc tgtgggactc ggggccggtc cgccaggccg agctgatcaa gaccctggac
     8881 ctggacccgt ccacggtcac caagatgctc cagcgcctcg aacagaccgg ccatgtgcgc
     8941 cgccgccccg acccggacga ccggcgggcc gtgctggtcg aggcgacgga cgagagctgc
     9001 gcgctgcaca cggcggtgcg ggacgcgtgg ggcagcctgg aggagcacac gctcgcggga
     9061 ctggcgagcg atgagcgtac ggagctgacg cggctgctgg cgaaggtgga ggcgaacctc
     9121 tgccacgaga cggagggctg cccggaacgg ggctgaaccc ccgcccgccc ccggcttccg
     9181 gccccctcag cccagcacgt ccaggactcg gtcgacgtcc gccccggtgt tgtagaggtg
     9241 gcaggagatc cgcaggttcc cggccggggc cgagaccgcg atcccggccc gggtgagctc
     9301 gtcgtggcgg ccgtccagcc ccggcacgga gacgatcgcc gactcccccg gcaccacctc
     9361 gtgacccagc tccaccagcc ccgagcgcag ccgggcggcg agcgaggtgg cgtgcgcgta
     9421 cagcgcgtcg atgccgacct ccgcgagcag ggccagggag tgctccgccc cgtggtacga
     9481 gaggaacgcg ggcggctcgt cgaacccgcg cgcaccgggg gcgacgcgct ccagcgggcc
     9541 gtagttgccg gtccagggcg ctccggcggc gacccatccg gcgaagaggt ggggcagggt
     9601 ggcctgcgcc tcctcggtca cggtgaggaa cgacgtaccc ctggggcaga gcaggtactt
     9661 gaagccgccg gtgacggtgt agtcgtaggc cccggcgtcc agcgggaacc agcccgccga
     9721 ctgggtggcg tccagcaggg tccgggcccc gtgggcggcg gcggccgcgc ggacggcggc
     9781 gaggtcggcg acccggccgt cggccgactg gaccgaggag aaggcgacga gcgcggtggt
     9841 gggccgtacg gcgtcggcga ggtccgcgag cgggacgtac cgcatacgca gatccccgcg
     9901 gagcgcgaac gggctgacca ccgagctgaa ctcaccctcg ggcgcgagga cttcggcacc
     9961 cgccgggagc gatgcggcga tcagcccgac atggacggtg accgagctgc cggtggcgac
    10021 ccgctccggc cggaccccgg cgagccgggc gaagccggcc cgggccgcct ccaccacgtc
    10081 gaagctgccc gcgccgatcc ggcggcctgc ggcgttctcg tcggcgaggg ccttgacggc
    10141 ggcgatggtg cggcggggca gcagccccca gctggaggtg ttgaggtacg tgacctccgg
    10201 ggcgaactcg gcggcggcca cctggcggag cggagagagc gtcatgcgcc cagcctggag
    10261 cccccgcgac ccatagtcaa ttgccggaat ctgtgcggag cacccaagaa atgcttatag
    10321 tcggcgccgt tgctcagccc ttcggaacct cacaggcgcc gtccgtgtcg caggccgccg
    10381 cgtcgccgcc gacggtggt
//
