LOCUS       NZ_CP032543            22214 bp    DNA     linear   CON 15-NOV-2023
DEFINITION  Streptomyces griseus subsp. griseus strain ATCC 13273 chromosome,
            complete genome.
ACCESSION   NZ_CP032543
VERSION     NZ_CP032543.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Complete genome sequence of Streptomyces griseus ATCC 13273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7238194)
  AUTHORS   Liu,J., Yu,B., Liu,X. and Shen,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2018) Jiangsu Key Laboratory of Tcm Evaluation and
            Translational Research, China Pharmaceutical University, Longmian
            Avenue, Nanjing, Jiangsu 211198, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2016
            Assembly Method                   :: SMRT analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/15/2023 05:04:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,408
            CDSs (total)                      :: 6,322
            Genes (coding)                    :: 5,933
            CDSs (with protein)               :: 5,933
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 389
            CDSs (without protein)            :: 389
            Pseudo Genes (ambiguous residues) :: 0 of 389
            Pseudo Genes (frameshifted)       :: 299 of 389
            Pseudo Genes (incomplete)         :: 144 of 389
            Pseudo Genes (internal stop)      :: 16 of 389
            Pseudo Genes (multiple problems)  :: 65 of 389
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:22:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 165372
            Orig. end                         :: 187586
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP032543.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from China pharmaceutical
            University, Jiangsu Key Laboratory of TCM Evaluation and
            Translational Research.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22214
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12214](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12214
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(122..850)
                     /locus_tag="D6270_RS00820"
     CDS             complement(122..850)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491110.1"
                     /locus_tag="D6270_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VanZ family protein"
                     /protein_id="WP_225976740.1"
                     /transl_table=11
                     /translation="MTVLTVVLLGLVVFSVLLAKVTLTPSPASEDLITSNLQPGRSLRQ
                     YAEDYTFLAACKQAGGNLLLGVPFGLLLPFLVPRRLRMISMTVLTAAVMIIVELVQGAL
                     VTGRAFDIDDVILNTAGALLGYLVLGRRISHSYHKRAHDPKAEAVEPAAEPEAAGRLKP
                     SRTGTKTGTKASTKAGSKAGTTRTGTSARGTAKAKEPSKAAARTGGTRLTKPKGSSGRP
                     TVGGTQPGSGRTLLNRLRRR"
     gene            1008..1508
                     /locus_tag="D6270_RS00825"
     CDS             1008..1508
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="D6270_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_109167705.1"
                     /transl_table=11
                     /translation="MSLREKKDLLAETDRLREEGRAGEARERLLVLTAEFPDDAEVAYR
                     TAWVHDVLGLETEAVAYYERSLAGTGLGREDRRGALLGLGSTYRVLGRYGQAVETLRRG
                     VEEFPDDGALQSFLAMALFNTEEHHEAMQLLLRLVASTSDDRQVQQYRPAIEHYAKDLH
                     ETM"
     misc_feature    complement(1036..1050)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            1605..2324
                     /locus_tag="D6270_RS00830"
     CDS             1605..2324
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606681.1"
                     /locus_tag="D6270_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YoaK family protein"
                     /protein_id="WP_204117240.1"
                     /transl_table=11
                     /translation="MHSPPPPPSPSSAAPRADGLSRRGEWALLLLSAASGAADAFVFLC
                     VGQVFAGVMTGNLVLLGASAAGAGEDGVALRVVTALAAYVCGAAAGALMAGLPPGLTLL
                     TESVLLGVAAVLWGFGLVASYGDRLGLLALVSLAMGVQGRIRVAPTNYFTGTLTSLAGR
                     TAARELTPGDVWVVGRLGAAVAGAGVAALAERWWSPGAALGPVALVASALVLETAPRGG
                     RDRGKPRPDRGNPAGAA"
     gene            complement(2551..2811)
                     /locus_tag="D6270_RS00835"
     CDS             complement(2551..2811)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606682.1"
                     /locus_tag="D6270_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_109167704.1"
                     /transl_table=11
                     /translation="MKPRIHPVSRPVVFRDRSADVAFLTRSTADSGERVAWEDGNTYPV
                     IDVETSSASHPFYTGGRQVLDTAGRVERFRRRYGTDGASRS"
     gene            complement(2890..3054)
                     /gene="rpmG"
                     /locus_tag="D6270_RS00840"
     CDS             complement(2890..3054)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192346.1"
                     /locus_tag="D6270_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_109167703.1"
                     /transl_table=11
                     /translation="MARSELRPVVTLRSTAGTGHSYVTRKSRRNTPDRLELRKFDPAAG
                     QHVLFREAR"
     misc_feature    complement(3086..3100)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    3099..3114
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    3101..3115
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(3103..3114)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            complement(3204..4031)
                     /locus_tag="D6270_RS00845"
     CDS             complement(3204..4031)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515114.1"
                     /locus_tag="D6270_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphotransferase"
                     /protein_id="WP_109167702.1"
                     /sec_met_domain="APH (E-value: 2.9e-09, bitscore: 35.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEQPRAPLPPQSVLDAFGLRGTPEPLTGGQGRSVRVGGAVLKPA
                     EGTEGESEWAVSLFERLPRGAGFRVPRPLRSAEGAGVVDGWTAAEFMDGRPGPSGQWPG
                     VVAAGRAFHAALREEPRPGFLARRTHPWAVADRVAWGEEEADIVAELAEPFGRLLALRR
                     PVEAAPQIVHGDLAGNVLFAPGQDPVIIDFSPYWRPALYAEAVVIGDGLLWYGPAPALT
                     AGGGGDPRWRQMLVRALIFRLVALSGLVGPSRSAGKKEGARFRAAADAVERGA"
     gene            4304..5719
                     /locus_tag="D6270_RS00850"
     CDS             4304..5719
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="D6270_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_109167701.1"
                     /transl_table=11
                     /translation="MPSHLFADRPAPQPPAHDAVDALIHRARQLRGDVDAVGRNAAVSD
                     EDDPQARWQRALCDLAVQHLDTLDQHLGQLKTGLPARRPAARDGDVPPDGPSAGSAPNR
                     VGSAEWNLLTDEVSWSDELYEIFGRPPGSPPLSLDDLPSVLFPDDQPKLTSMVTGCLVD
                     GQPMDGEFRIVLPDGRVRTLHMTGEPVLDPEGCTASMWAVLRDVGELRRSEETVGRNRD
                     SARRDGRTEHRTAEELQETALPPWRGPSHLARQGPGVLDIAAHHLPSASGGLIGGDWYD
                     AMELPDGGTLLAVGDLTGPAIPATSALAMVLGAVRGMAVAGVRPGALLGHLDHLLETSM
                     RPALGSALCCHVDPATGLLSWAQAGHPAPLLFRDGTGRRLPPPEGALLGAASRLAHEQD
                     EVRLLPGDVLVLHTDGLTRRSGPGAGPEQLLALAPLFAQARDAQECVRGVVEEFGGAER
                     LDDACVLVARIGA"
     gene            complement(5813..7309)
                     /locus_tag="D6270_RS00855"
     CDS             complement(5813..7309)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606686.1"
                     /locus_tag="D6270_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109167700.1"
                     /transl_table=11
                     /translation="MTGEPNTRLSDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRVGKRRDSGTEHDPDQL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSTIAGPMYDWLHSDPVLAADAPR
                     ANDPQHADPAGFDRYEAAPVGSEEIEALEHSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGEETLPRTQAMLRTIEAWAQAAMGRGQA
                     MRRTLGEAEELFVSDKGDVPTPSWMQMFDEADMHGMQALAFRTLAEHDPGAASIAQRHA
                     KQALELRVNGRQRSKLFDHISLASACFIANDPEQGDRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQFAGYAKIQDLREQIELSLPQSPVTKKARGTQA"
     gene            7541..8677
                     /locus_tag="D6270_RS00860"
     CDS             7541..8677
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="D6270_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_109167699.1"
                     /sec_met_domain="APH (E-value: 2.2e-17, bitscore: 62.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRSMGTGGGPYLAPHAGAPAQGLGRTRRAAG
                     PGAGPLSGRIDLSGPQGAQVRMAIASVQRICPEFNPVQVLRRSGRSVLIVGTTGRATAV
                     AKCLLDHSPAWTERFQHEIAAYRAFVRHRPPVRVPRLIAADPENCTLVIERMPGRVAAL
                     TRHPAEAPPRADIRAALGAIARVNAWRPPPGLFEAPLDYASRISRYHELGLFTDRDLGD
                     LQKLLHGLAQAGGRQSMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWT
                     VLGDAPVARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPSVSAG
                     QDRPGVLSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    7862..7864
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9137..9823
                     /locus_tag="D6270_RS00865"
     CDS             9137..9823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="D6270_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_109167698.1"
                     /transl_table=11
                     /translation="MPRTIRITRSHKLATAVLVAAGSVTAITATGGQSEAQPAAAKSSV
                     AAEKIATGVPTAKEIASKRAAADTAAKKAAAERKAAAEKAVAERKAAAKKSAEKAHSEK
                     QTANRSTERKAVAAPKQYKNNLDGWIRESLDIMKKKNIPGSYEGLHRNILRESSGNPNA
                     VNDWDVNAQNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDPVANITAAANYAADKYGSID
                     NVDSAY"
     misc_feature    complement(9882..9896)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.69"
                     /tool="antismash"
     gene            10001..12214
                     /locus_tag="D6270_RS00870"
     CDS             10001..12214
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606689.1"
                     /locus_tag="D6270_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_109167697.1"
                     /sec_met_domain="T1TS (E-value: 6.6e-85, bitscore: 284.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHVEAARTHTRQWARGMGMLEGSGIW
                     EEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGAKRY
                     LDRLPAFMPMERGAATPEPENPVEAGLADLWERTVPAMSDAWRARFAEATENLLNESMW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYAANAEVPAAVADARPLRVLRDAFS
                     DGVHLRNDLFSYQREVEEEGENSNGVLVLERFLGCSTQEAAEAVNDLLTSRLHQFENTA
                     LTELGPLCAEKGLDPAQTASVLAYVKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGFG
                     MSAASIKFTPRSETARARSHSHLPFRHVGPSLVPDLELPFGTTLSPHLEGARVRLVDWA
                     RRMGILEAQPGIPGSHIWDEDRILAIDLPLCAAGIHPDASPDELDISSAWLAWGTYGDD
                     WFPVVHGRTRDLAGARLANERLSLFMPLDGEAAPEPVNALERSLGDLWRRTAGPMDPDA
                     RRTFRTAIESMTESWLWELANQAQNRIPDPVDYVEMRRATFGSDLTMSLCRLGHGRTVP
                     DAVYRSGPMRSLENAAADYACLLNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVA
                     IVHDLMKSRLRQFLHVAEVELPVLYDDFGLDAEAREVLAGYVQELKHWLAGILIWHRGC
                     RRYREEDLRRGHGAPWHLGGPTGLGTSAAQVTRLMAELAGSRG"
     gene            complement(12391..12891)
                     /locus_tag="D6270_RS00875"
     CDS             complement(12391..12891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="D6270_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_093694429.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEDGQVPFEVAQLLLALENDEPIEVVSSEDV
                     PVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     misc_feature    12894..12904
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            13155..14702
                     /locus_tag="D6270_RS00880"
     CDS             13155..14702
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515107.1"
                     /locus_tag="D6270_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_109167696.1"
                     /transl_table=11
                     /translation="MTVEGTVSGLEERAVGRAWMVRLDPADRGGAAVRVSCGRPACAPQ
                     VLPSAAVGRTAAVAHLATHLRAAAGPRPEAYCACRAEECHTHTRETGPRERATPSRCGG
                     PVVMAVINDRQGRWWRALECCARCAAAHPSARIVATAPAAASPAPTPGARPPAGRPPVP
                     AGPQFSHAASSPAAVPRAVPAPRPKPRRNRRTGKIAQRIVPHDLHPVALRDELIELGDL
                     FRAYQQRPEPDLAQLAELHSRKAVAFTRWWEVTGETDLRLEAQRAEQAAAAALLQHQQR
                     TGQSPVGDGEVTSRLLPGLTQWDHARTVLAHVADHTPLPGPEARLMAVVLTLRSALTGT
                     GNLVGQDVKGLPLTEPEELIGRLLDSGWLSIPGTADDLLASRPESPTPITIPSLMPDED
                     GEGPFDFGRKTRPKLSGWAQRVVGDRKLRKKKTGAAVRLLALALAIRTTIDGRLGPEGE
                     GIDTAVLTSWCAVDSGELEPLVEQLTAADWLEEAAVTDGRLTGRLAERVLPLSCPLP"
     gene            complement(14715..15881)
                     /locus_tag="D6270_RS00885"
     CDS             complement(14715..15881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="D6270_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_109167695.1"
                     /transl_table=11
                     /translation="MPKEPVAVVGIGQTKHVAARHDVSIAGLVREAAVRALADAGLTWS
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHIHDPDITLEKVQASPMLWDPIRYSETCPSSDGACAMILTDRE
                     GARRAPHPPAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQARITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFAGEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGEHQIEGATRAVGHAYGGGAQFFAMWLVGSQPPPG"
     gene            complement(15874..16926)
                     /locus_tag="D6270_RS00890"
     CDS             complement(15874..16926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550730.1"
                     /locus_tag="D6270_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_109167694.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQTAHRRRTDELSEVDLLMPVLHEVLGATGLKANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKIMTGEADTA
                     LVYSYGKSSPGEVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGDTDEAALASIA
                     ARSRADATTNPHAQLTGDVPAGDHLVHPLRTGDCPPIGDGAAAVILAVGETARALCARP
                     AWIRGIDHRIEAHSLGVRDLTDSPSTRLAAQHAGAFERPVDTAELHAPFTSQEVVLRKA
                     LTLGDDTRVNPSGGALAANPIMAAGLIRLGEAAARIHRGESDRALAHATSGPCLQQNLV
                     AVLEGETAHA"
     gene            complement(16927..17874)
                     /locus_tag="D6270_RS00895"
     CDS             complement(16927..17874)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="D6270_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_109167693.1"
                     /transl_table=11
                     /translation="MTDVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTDEGTV
                     LVPPVEYDPVTANELRELVEVAATGTVTTWAWNPSPRRNQPLGTPFAWVLVRLDGADTA
                     LLHALDAPGPDAVHAGMRVRIRWAATRTGAITDIACFEPYDGAAGPDEPAPHDGEFTDP
                     VTGIVAAARLDYVHSPGRAQSAYLKALAGHRTVGERCPACRKVYVPPRGACPTCGIATA
                     EQVEVGPRGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGADLALHGRIAGIPYDQVRMG
                     LRVEPVWAEGTAHPDHYRPTGEPDADYDTYKELV"
     gene            complement(17898..18698)
                     /locus_tag="D6270_RS00900"
     CDS             complement(17898..18698)
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 7.6e-53. Score:
                     171.3. Matches aSDomain:
                     nrpspksdomains_D6270_RS00900_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="D6270_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_109167835.1"
                     /transl_table=11
                     /translation="MGGTEHLTVERRGATLVLTLNRPQARNALSLPMLVGLYDGWLAAD
                     ADDEVRSVVLTGAGGAFCSGMDLKALAGGGMEGEEYRERMAADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRPYTADEACAIGLVGRVVPDGTALEEALAVAERINACGPLAVEAVKASVYE
                     GAELTETEALAAELKRGWPVFATEDAKEGARAFAEKRPPVYRRA"
     aSDomain        complement(17925..18671)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS00900_ECH.1"
                     /evalue="7.60E-53"
                     /label="D6270_RS00900_ECH.1"
                     /locus_tag="D6270_RS00900"
                     /protein_end="258"
                     /protein_start="9"
                     /score="171.3"
                     /tool="antismash"
                     /translation="ERRGATLVLTLNRPQARNALSLPMLVGLYDGWLAADADDEVRSVV
                     LTGAGGAFCSGMDLKALAGGGMEGEEYRERMAADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     PYTADEACAIGLVGRVVPDGTALEEALAVAERINACGPLAVEAVKASVYEGAELTETEA
                     LAAELKRGWPVFATEDAKEGARAFAEK"
     misc_feature    18752..18767
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    18753..18769
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    18757..18771
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     misc_feature    complement(18774..18787)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            18865..20484
                     /locus_tag="D6270_RS00905"
     CDS             18865..20484
                     /NRPS_PKS="Domain: AMP-binding (8-437). E-value: 5.1e-65.
                     Score: 211.6. Matches aSDomain:
                     nrpspksdomains_D6270_RS00905_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491125.1"
                     /locus_tag="D6270_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_109167692.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-68, bitscore:
                     229.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALLYVDHPGTGAERRLTYAGLDAAA
                     NRIAHHLIGAGLRPGEHLGLHLYNGIEYLQTVLGALKARLVPVNVNYRYVEEELVYLYR
                     DADLAALVFDGEFDERVAAASAQAPGLRHLVRIGPTAAPTGLEAMPFTEAEASGSPTRG
                     FQPRSADDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPQELAERVAAG
                     GDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEREKVTSVSLVGD
                     AMLRPLIDALNGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESG
                     FNGTATADSGPEHGFRVQVNARTAVVDPATYEPVTPGEVGRIAQRGHVPLGYYNDPAKT
                     ADTFFRKGDERWVLLGDMATVDAEGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPDV
                     YDALVAGVPDERWGSRVAAVLELREGARALDLEAVQAHCRTRLAGYKIPRALVLTDRIQ
                     RSPSGKADYRWAKAVAAAGTAG"
     aSDomain        18889..20175
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS00905_AMP-binding.1"
                     /evalue="5.10E-65"
                     /label="D6270_RS00905_AMP-binding.1"
                     /locus_tag="D6270_RS00905"
                     /protein_end="437"
                     /protein_start="8"
                     /score="211.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALLYVDHPGTGAERRLTYAGLDAAANRIAHHLI
                     GAGLRPGEHLGLHLYNGIEYLQTVLGALKARLVPVNVNYRYVEEELVYLYRDADLAALV
                     FDGEFDERVAAASAQAPGLRHLVRIGPTAAPTGLEAMPFTEAEASGSPTRGFQPRSADD
                     QFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPQELAERVAAGGDGITFFP
                     TPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEREKVTSVSLVGDAMLRPLID
                     ALNGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESGFNGTATAD
                     SGPEHGFRVQVNARTAVVDPATYEPVTPGEVGRIAQRGHVPLGYYNDPAKTADTFFRKG
                     DERWVLLGDMATVDAEGIVTVLGRGSQCIN"
     CDS_motif       19381..19431
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS00905_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="D6270_RS00905"
                     /protein_end="189"
                     /protein_start="172"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     CDS_motif       20026..20073
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS00905_0002"
                     /evalue="3.40E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="D6270_RS00905"
                     /protein_end="403"
                     /protein_start="387"
                     /score="13.1"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     gene            complement(20495..22015)
                     /locus_tag="D6270_RS00910"
     CDS             complement(20495..22015)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-266). E-value:
                     3.6e-25. Score: 80.9. Matches aSDomain:
                     nrpspksdomains_D6270_RS00910_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956456.1"
                     /locus_tag="D6270_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_151414644.1"
                     /sec_met_domain="PF00561 (E-value: 2.9e-20, bitscore: 71.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.6e-18, bitscore:
                     65.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFSAYDTTQLAYHLVGEGEPLICLPGGPMRASAYLGDLGGLSA
                     VRQLVLLDLRGTGESAVPEDPSTYRSDRLVADVEALREHLGLDRIDLLAHSAGADLAQL
                     YAARHPERLRTLTLITPSTRAAGIEVTDQDLREAAELRSGEPWYAEARAAQEALLAGGP
                     FAELWPAVRPLTYGRWDDAARAHAAASAGQTNPEARGRYGDGTYDPATTVPALRGLPVP
                     VLVLAGEYDGHPSPDRATELAALFPYGEFTVQRGAGHFPWLDDPGAFSRTVAAFLDPDV
                     LTVHAGGVRLAYRVWGEPSAPPVVLLHGRAGSSLTWTRVAEELAAEHRVYAPDFRGHGL
                     SDWPGRYSFELFRDDLHAFLEARNLAGATVVAHSMGGVAAYLLAQREPGLIGRLVIEDA
                     PPLLPLDPPRPRSERPEGELDFDWPVVADTDAQLNDPDPTSRDRLAEITAPTLIIGGGA
                     TSHIDQKQLAGMADTIPDAVFTTIEAGHLVHTTRPDEFLAALRSFGLL"
     CDS_motif       complement(20858..20899)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS00910_0002"
                     /evalue="3.60E-03"
                     /label="NRPS-te1"
                     /locus_tag="D6270_RS00910"
                     /protein_end="386"
                     /protein_start="372"
                     /score="9.9"
                     /tool="antismash"
                     /translation="HSMGGVAAYLLAQR"
     aSDomain        complement(21218..21952)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D6270_RS00910_Abhydrolase_1.1"
                     /evalue="3.60E-25"
                     /label="D6270_RS00910_Abhydrolase_1.1"
                     /locus_tag="D6270_RS00910"
                     /protein_end="266"
                     /protein_start="21"
                     /score="80.9"
                     /tool="antismash"
                     /translation="PLICLPGGPMRASAYLGDLGGLSAVRQLVLLDLRGTGESAVPEDP
                     STYRSDRLVADVEALREHLGLDRIDLLAHSAGADLAQLYAARHPERLRTLTLITPSTRA
                     AGIEVTDQDLREAAELRSGEPWYAEARAAQEALLAGGPFAELWPAVRPLTYGRWDDAAR
                     AHAAASAGQTNPEARGRYGDGTYDPATTVPALRGLPVPVLVLAGEYDGHPSPDRATELA
                     ALFPYGEFTVQRGAGHFPWLDDP"
     CDS_motif       complement(21695..21733)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D6270_RS00910_0001"
                     /evalue="4.10E+00"
                     /label="NRPS-te1"
                     /locus_tag="D6270_RS00910"
                     /protein_end="107"
                     /protein_start="94"
                     /score="0.2"
                     /tool="antismash"
                     /translation="HSAGADLAQLYAA"
ORIGIN
        1 ggcagtcgcg gcgtgccctc ccggacgggc tggggcagca ctggcccgcc gggcgggtcc
       61 ggcccgtcgg gcggcgctgt gccgtccgcg cggcgggagg ggaaaagggc gccccctggg
      121 gtcagcgcct gcggaggcgg ttcaggaggg tgcggccgga gccgggctgc gtgccgccca
      181 cggtggggcg accgctcgaa cccttgggct tcgtcaggcg cgtgccaccg gtccgcgccg
      241 ctgccttgga cggctccttc gccttggccg tgccccgggc actcgtcccg gtcctcgtcg
      301 tccctgcctt actcccggcc ttcgtgctgg ccttcgtccc ggtcttcgtg ccggtccggg
      361 acggcttcag cctccccgcc gcctcaggct ccgccgcggg ctcgaccgcc tcggccttcg
      421 ggtcgtgggc gcgcttgtga tagctgtggc tgatccggcg gcccagcacg aggtaaccga
      481 gcagggcgcc cgccgtgttg aggatgacgt cgtcgatgtc gaaagcacgg ccggtgacca
      541 gggcgccctg gaccagctcc acgatgatca tgacggcggc ggtcagcacc gtcatgctga
      601 tcatccgcag gcggcgcggc acgaggaacg ggagcagcag cccgaagggc acgccgagca
      661 gcaggtttcc gcccgcctgc ttgcacgcgg cgaggaaggt gtagtcctcg gcgtactggc
      721 gcagcgaccg gcccggctgg agattcgagg tgatcaggtc ctcggaggcc ggggaggggg
      781 tgagggtcac cttggccagg aggacggaga acaccaccag ccccaacagc accacggtca
      841 ggacggtcat cctcagcagc acgcgcgccc atgccccctg tcgcgcaggg gggttcgtct
      901 ctgcagtcat ggcggacagt tgcccgcgcc ggggcggaaa acacccgggt ggacgtccga
      961 gcctgaaaat cgcccggccg tccggtgccg cctgcgacga tgggcccatg agcctacgtg
     1021 agaagaagga cctgctggcc gagaccgacc ggctgcgcga ggagggccgg gccggggagg
     1081 cgcgtgagcg gctgctcgtc ctgaccgccg agttccccga cgacgcggag gtggcctacc
     1141 ggaccgcgtg ggtccacgac gtcctgggcc tggagaccga ggcggtggcc tactacgaac
     1201 gcagcctggc ggggacgggg ctcggcaggg aggaccggcg gggggcgctg ctgggtctcg
     1261 gcagcaccta ccgggtgctg gggcggtacg gacaggccgt ggagacgctc cgccggggcg
     1321 tcgaggagtt tcccgacgac ggggcgctgc agtcgttcct ggcgatggcc ctgttcaaca
     1381 ccgaggagca ccacgaggcg atgcagctgc tgctgcggct ggtggcgtcg acgagcgacg
     1441 accggcaagt gcagcagtac cggccggcca tcgagcacta cgcgaaggat ctgcacgaga
     1501 ccatgtgacc cggggcatcg ccggcagggg acgtacccgt acgcggcgcg ccgcgtcggc
     1561 ggcggagcgc ggtcccgcaa cgcgtaccta ccgagaatgc tcgggtgcac tcccctcccc
     1621 cgcccccgtc cccctcgtcc gccgcgcccc gggccgacgg cctctcccgg cggggagagt
     1681 gggcgctgct gctcctgtcc gcggcttccg gggcggcgga cgcgttcgtc ttcctctgtg
     1741 tgggccaggt cttcgccggg gtgatgaccg ggaatctggt gctgctcggg gcctcggcgg
     1801 ccggagcggg tgaggacggg gtggcgctgc gggtggtcac cgccctggcg gcgtacgtct
     1861 gcggggccgc ggccggtgcg ctgatggcag ggctcccgcc gggactgacg ctgctgaccg
     1921 agtccgtcct gctcggggtg gccgccgtgc tgtgggggtt cggtctggtg gcgtcgtacg
     1981 gtgaccgcct cgggctgctg gccctcgtgt cgctggcgat gggcgtccag gggcgcatcc
     2041 gggtggcgcc gacgaactat ttcaccggga ccctcacctc gctggccggc cggacggcgg
     2101 cgcgggagct gacgccgggg gacgtctggg tggtgggccg gctgggggcg gcggtggccg
     2161 gtgcgggggt cgcggcgctg gcggagcggt ggtggagccc gggggccgcg ctgggtccgg
     2221 tggcgctggt ggcctcggcg ctggttctcg aaaccgcgcc gcgtgggggc cgggacaggg
     2281 ggaagccccg gccggatcgg gggaatccag ccggggcggc ttgagtgcgg ggatgaaggg
     2341 cggtcacctc tcggcgaggg gctccatggg gcttcggcgg tgcgaactct ccccatgggc
     2401 tgttggtgag gcccggggac accgtccccc tcacacccac gtatagatga acgataaacc
     2461 atctcggacc gttcccggga accctccccc gcggatgtga tccacggcac ggaatccccg
     2521 gttccgccgt ctgccgaaga gcagatgcga tcagctccgg gacgccccat cggtgccgta
     2581 gcggcgccgg aaccgctcca cgcggccggc cgtgtcgagt acctgacgac ccccggtgta
     2641 gaacgggtgg ctcgcggacg aggtctcgac gtcgatgacg gggtaggtgt tgccgtcctc
     2701 ccatgccacg cgctcgccgg agtcggcggt ggagcgggtc aggaaggcga cgtccgccga
     2761 gcggtcgcgg aagaccacgg ggcgggagac ggggtggata cgaggcttca tcgatgcgtt
     2821 ccttcctcac cgcggatggc ggtgacggtg gcgtacggga gtgcttccgc tcgggtcggc
     2881 tccgcccggt cagcgggctt cgcggaagag gacgtgctgc ccggcggcgg ggtcgaactt
     2941 gcgcagttcc agccggtcgg gggtgttgcg gcggctcttg cgggtgacgt agctgtggcc
     3001 ggtgccggcg gtggaccgga gggtcacgac gggcctgagc tcgctgcgtg ccatgggcgc
     3061 ctcctgcggg actcgacgac cccacctctc ataacgggaa tgggattcgt tttcgttctg
     3121 gtggagtaac gcgccatacc ccgtcggcat tcccggccgg gtcacaccgg cgccggcagc
     3181 cctcagggcc gtgccctacc cccttacgcc ccgcgctcca cggcatccgc ggccgcccgg
     3241 aagcgggcac cctccttctt cccggcggac cgggacgggc cgacaaggcc gctcagcgcg
     3301 acgagccgga agatcagtgc gcgaaccagc atctgacgcc agcgggggtc gccgcccccg
     3361 cccgccgtga gagcgggggc ggggccgtac cagagcaggc cgtcgccgat caccacggcc
     3421 tccgcgtaga gagccgggcg ccagtagggg gagaagtcga tgatgacggg gtcctggccg
     3481 ggcgcgaaga ggacattgcc ggcgaggtcg ccgtggacga tctgcggcgc cgcctccacg
     3541 ggccgccgca gggccagcag ccgcccgaac ggctcggcga gctccgcgac gatgtcggcc
     3601 tcctcctcgc cccaggcgac gcggtcggcc accgcccagg ggtgggtacg gcgggcgagg
     3661 aagccggggc ggggctcctc ccgcagggcg gcatggaagg cgcgccccgc ggcgacgacg
     3721 ccgggccact gtccgctggg gccggggcgg ccgtccatga actcggcggc cgtccagccg
     3781 tcgaccacac cggccccctc ggccgaacgc aggggtcgcg gcacccggaa gccggcgccc
     3841 cggggcagcc gctcgaagag ggacacggcc cactccgact ccccctcggt cccctccgcg
     3901 ggcttcagga cggccccgcc gacgcggacg ctgcgtccct gaccaccggt cagcggctcg
     3961 ggggtgccgc gcaggccgaa ggcgtcgaga acggactgcg ggggaagggg ggcacgcggc
     4021 tgttcgggca tgcgaggcat cctgccggtc ggccccgccg cacgcacccg gattcacttt
     4081 gggctcgtcc gtcgcggggg cctatgccac cggggctgac caacacccct tatccgtacg
     4141 cccgttcggc ggatcaccgt ctccgcacag cctgtggcat atgccataag caacaaccca
     4201 tcgagtgttg tcgaatccct tacgggccgc cgcggcctgt gcgacagtcg atagcggtcg
     4261 acccctgaga cccggccgca ccgcgcctgt atcggagtac gagatgccgt cccatctgtt
     4321 cgcggaccgc cccgcaccac agccccccgc gcacgatgcc gtcgacgcct tgatccaccg
     4381 ggcgcgccag ctgcgcggag acgtggacgc cgtgggacgg aacgcggccg tgagcgacga
     4441 ggacgacccc caggctcgct ggcagcgcgc cctgtgcgac ctggccgtcc agcacctcga
     4501 caccctcgac cagcatctgg gccagctcaa gaccggtctg ccggcccggc gccccgccgc
     4561 ccgggacggc gacgtacccc cggacggccc gtcggccggt tccgcgccga accgggtggg
     4621 cagcgccgaa tggaacctcc tcaccgacga ggtcagctgg tcggacgagt tgtacgagat
     4681 cttcggccgg ccacccggtt cgcctccgct gtccctggac gacctgccgt ccgtgctgtt
     4741 cccggacgac cagcccaagc tgacctccat ggtgaccggc tgcctcgtgg acgggcagcc
     4801 gatggacggg gagttccgca tcgtgctccc cgacggccgg gtccgcacgc tgcacatgac
     4861 gggagaaccg gtcctcgacc cggagggctg caccgcctcc atgtgggccg tgctccggga
     4921 cgtcggcgag ctgcgccgca gcgaggagac cgtcggccgg aaccgggatt cggcccgccg
     4981 tgacgggcgt acggaacacc ggacggcgga agagctccag gagaccgcgc tgccgccctg
     5041 gcgcggcccg tcacacctcg cccggcaggg ccccggcgtc ctggacatcg ccgcccacca
     5101 cctcccttcc gcctccggcg gcctcatcgg cggcgactgg tacgacgcga tggaactgcc
     5161 cgacggcggg accctgctgg ccgtcggcga tctgaccggg cccgcgatcc ccgccacctc
     5221 ggccctggcc atggtgctcg gcgcagtgcg cggcatggct gtcgccggcg tccggccggg
     5281 cgccctgctg gggcacctcg accacctcct cgaaacatcg atgcgacccg ccctgggcag
     5341 cgccctgtgc tgccatgtcg atccggcgac cggcctcctc tcctgggcgc aggcgggaca
     5401 ccccgcgcca ctgctcttcc gcgacggaac ggggcgccgg ctgcctcccc cggagggggc
     5461 gctgctcggt gccgcgtccc ggctcgccca tgagcaggac gaggtgcgcc tgctccccgg
     5521 cgacgtgctg gtgctgcaca cggacggcct gacgcgccgc agcggcccag gtgcgggccc
     5581 ggagcaactg ctcgccctcg cccctctgtt cgcacaggcc cgtgacgcac aggagtgtgt
     5641 acggggtgtg gtcgaggagt tcggcggggc cgagcgcctg gacgacgcgt gtgtgctggt
     5701 cgcccgcatc ggggcatgag ggagcgcgag accggccctc agggctgact gcgcgtcatg
     5761 acggtgggta cgcgcggcgg ttacggcctc cgccggcgga cacgtagggg aatcaggcct
     5821 gtgtacccct ggcctttttg gtgacggggc tctgcggcag ggagagttcg atctgctcgc
     5881 ggaggtcctg gatcttggcg tatcccgcga actggccggt gagccggtac atttcgcgca
     5941 gccggtccca ggtgcggtgc gaggaggtct cccccatcga caccagcgcg agccgggcgt
     6001 accggtcgcc ctgttcgggg tcgttggcga tgaagcaggc cgaggcgagc gagatgtggt
     6061 cgaagagctt ggaccgctga cgtccgttga cccgcagctc cagggcctgt ttggcgtggc
     6121 gctgggcgat ggacgccgca ccggggtcgt gctcggccag agtgcggaac gccagggcct
     6181 gcatgccgtg catgtcggcc tcgtcgaaca tctgcatcca gctcggggtc ggcacatcgc
     6241 ccttgtccga gacgaagagc tcctccgcct cgccgagggt gcgccgcatg gcctggcccc
     6301 tgcccatcgc cgcctgcgcc caggcctcga tggtgcgcag catcgcctgt gtacggggca
     6361 gggtctcctc gcccgagccg gatttcgcca gcttcatcag gtcgagggca tcgtcggggc
     6421 ggcccaggtg caccatctgg cgcgcggcgc gggagagcgc ctcaccggcg cgcggccggt
     6481 cgccgccctc cctggccgcg tgggcggcga tgacgaagta cttctgggcg gtcggttcga
     6541 ggcccacgtc gtgggacatc cacccggcca gtacggcgag gttggcggcg acgccccaca
     6601 ggcggcgctg gagatggtcg gggtggcggt aggcgagcat gccgcccacc tcgttgagct
     6661 ggcccacgac ggccttgcgc tggagtccgc cgccacggga ggcgtcccag gcgcggaaca
     6721 cctcgacgga gtgctccagg gcctcgatct cctcggagcc cacgggcgcg gcctcgtacc
     6781 ggtcgaaacc ggcggggtcg gcgtgctggg gatcgttggc gcgtggcgcg tcggccgcca
     6841 ggacggggtc gctgtgcagc cagtcgtaca tagggcctgc gatggttgag ccggcggcga
     6901 gcgcggcgcc cgcacccacc aagccgcgtc ggttgagcat gaggtccatt cccgtgaatt
     6961 cggtgaggac cgctgccgtc cgttcgggcg cccacggcag ttgatcgggg tcgtgttccg
     7021 tacccgagtc ccgccgtttc cccacacgcc cgcgtcggcc gaacccgagg tcctcgatgg
     7081 tcacgacacg gccgagccgc tcggtgaaca gggctgccag cacttcgggc acgggatcac
     7141 ggggggactc ccccatgtcg atccagcgcc tgacccgcga ggtgtcggtg gccagctgcg
     7201 ggtggcccat ggccgccgcc tgccggttca ccattctcgc gagttcgccc ttggaccagc
     7261 cggccaggcc gaacaggtcg gaaagacggg tgttgggttc tccggtcacg tcaagccccc
     7321 aggttctcgg ctgacttgac actaaccccc tgtcagatgc gccgggacta ttcgccaggg
     7381 ttcgccaggg tccgccagat ggtctgccac ccgtgacccg gtgtcaggta ggaaagcgcc
     7441 accccgcccg gcagccctag gtactcccca gggtgccgaa cggccgtcgg ccgggttggc
     7501 gcacgtaact tgtcggcgca cgaagggatc tgtctcgccc atgtacacag catcgtcctc
     7561 cgtgtccgcc ccgccccggc cgctccgttc catggggacg ggcggcgggc cgtatctcgc
     7621 cccccacgcc ggtgcgccgg cgcagggcct gggccggacc cggcgggcgg cgggaccggg
     7681 tgcaggaccc ctcagcggac gaatcgacct ctccgggccg cagggcgcgc aggtgcggat
     7741 ggccatcgcc tccgtgcagc gcatctgccc cgagttcaac ccggtccagg tcctgcggcg
     7801 cagcggccgc tccgtgctga tcgtgggcac caccggccgg gccaccgccg tcgcgaagtg
     7861 tttactggac cactcccccg cctggacgga gcggttccag cacgagatag cggcgtaccg
     7921 cgcgttcgtc cggcaccgcc ccccggttcg ggtgccccgg ctgatcgcgg cggacccgga
     7981 gaactgcacg ctggtgatcg agcggatgcc cggccgggtg gcggcgctga cccggcaccc
     8041 ggcggaggcg ccgccgcggg ccgacatccg tgcggcgctc ggcgcgatcg cccgggtgaa
     8101 cgcctggcga ccgccgcccg ggctgttcga ggcgccgctg gactacgcct cgcggatctc
     8161 ccgctaccac gagctcgggc tgttcaccga ccgcgacctg ggcgacctgc agaagctgct
     8221 gcacggcctg gcccaggcgg gcggccgtca gtccatgggt cagttctgcc acggtgacgc
     8281 gctgctctcc aacatcctgc tgtcgccgac cgggccggtg ctggtcgact gggagcacgc
     8341 gggctggtat ctgcccggct acgacctggc gaccctgtgg acggtgctcg gtgacgcccc
     8401 ggtggcgcgg cgccagatca gccagctggc gcaggcgagg ggcccggccg cacgggacgc
     8461 gttcctggtc aacctgatgc tcgtcctgac gcgggagatc cgtaactacg agacggccgt
     8521 gcagcgcacc atgcgggagg cgccgtcggt gagcgcgggc caggaccggc cgggggtgct
     8581 ctcctcgggc gaggagcagc ggctgctgct gcgcaggctg cacgacgact gcgcgatggc
     8641 gcggcgggcg gtgcgggcgg cggtcgggac gcgctgagcc cgcgggcgcg agggcgccga
     8701 agagccactg tgcaagggaa gcgcgctgcg ggaccggtgc cgacacaccg ctcccgcagc
     8761 gcgctgtgct gttctccgat gcccccgtag acggccccgc tccgtgacag agcgctgacc
     8821 ggctgccatc cggaggccgc ccccaggtga ggcgcgccac gagacccacg tcacctacga
     8881 gcttcggtag tgggcgcggg ccctccacca cggcgccacg aaacgaccaa agcggtcatt
     8941 caccccaatc tcctatcaga ggtagtaaat agggtcattg cttcctgtcc tggcggacgt
     9001 taaccatgga tcccggcaag caccgagacc gagcctgcga cgagcgccca ccggcggtcg
     9061 gcagccgaaa tcccctcggt ctctgctcac gcggccccag gccgcagatc ccgtccccaa
     9121 caggaagagc tcacgcatgc cccgcaccat ccgcatcacc cgctcccaca agctcgccac
     9181 cgccgtgctc gtcgcggccg gttccgtcac ggccatcacc gcgaccggcg ggcagagcga
     9241 ggcacagccc gccgcggcca agtcctccgt cgccgccgag aagatcgcca ccggcgttcc
     9301 cacggcgaag gagatcgcgt cgaagagggc agccgccgac accgcggcga agaaggccgc
     9361 ggccgagcgg aaggccgccg cggagaaggc cgtggccgag cggaaggccg ctgccaagaa
     9421 gtccgccgag aaggcgcact ccgagaagca gaccgccaac cgctccaccg agcgcaaggc
     9481 cgtcgccgcg cccaagcagt acaagaacaa cctcgacggc tggatacgcg agtcgctcga
     9541 catcatgaag aagaagaaca tccccggctc ctacgagggg ctgcaccgca acatcctgcg
     9601 cgagtccagc ggcaacccga acgccgtcaa cgactgggac gtcaacgcgc agaacggcat
     9661 cccctccaag ggcctgctcc aggtgatcca gccgaccttc gacgcgtacc acgtcaaggg
     9721 caccccgaag aagctcaccg acccggtggc caacatcacc gccgccgcca actacgcggc
     9781 ggacaagtac ggctccatcg acaacgtcga ctccgcgtac tgagtccggg tcgatcccgc
     9841 ccgccgggcg gaccgccgcc gaaagggccg aaccagaccg cgatcatctg actaatcgcc
     9901 ctggtgcgtg ccccggttgg ccgaagggta gagctggcgc ggacaccact ggtccgcgca
     9961 cccaccactg cgcggaggct tccggaaagg cctgacgcac atggcacagc ccttctcact
    10021 gccggacttc tatgttccgt atccggcacg gctcaaccct catgtggagg cggcacggac
    10081 gcacacgcgt cagtgggccc gcggcatggg gatgctggag ggatccggca tctgggagga
    10141 gaaggacctg gaggcgcacg actacgctct gctctgcgcc tacacccacc ccgactgctc
    10201 ggccgaggca ctgtccctgg tcaccgactg gtatgtgtgg gtcttcttct tcgacgacca
    10261 cttccttgag ctgttcaagc gcacgcccga ccgcgagggt gccaagcggt atctggaccg
    10321 gctgcccgcc ttcatgccga tggagcgcgg ggccgcgacc cccgagccgg agaaccccgt
    10381 cgaggcgggc ctcgccgatc tgtgggagcg gacggttccc gcgatgtcgg acgcctggcg
    10441 ggccaggttc gccgaggcga cggagaacct cctcaacgag tcgatgtggg agctctccaa
    10501 catcaacgag ggccgcatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgcaccc tggtcggccg gactcgtgga gtacgcggcc aacgccgagg tgccggcggc
    10621 ggtggccgac gcccgccccc tgcgggtcct gcgcgacgcc ttctccgacg gggttcacct
    10681 gcgcaacgac ctcttctcgt accagcgcga ggtcgaggag gagggcgaga acagcaacgg
    10741 ggtcctcgtc ctggagaggt tcctcggctg ctccacgcag gaggccgccg aggccgtcaa
    10801 cgacctgctg acctcacggc tccaccagtt cgagaacacg gccctcaccg aactgggccc
    10861 gctctgcgcg gagaagggcc tcgacccggc gcagaccgct tccgtcctcg cgtacgtcaa
    10921 ggggctccag gactggcagt ccggcggcca tgagtggcac atgcgctcca gccgctacat
    10981 gaacggcggc ggggccggtg aggcggtggc gggcttcggc atgtccgccg cctcgatcaa
    11041 gttcacaccg cgttcggaga cggcgcgcgc ccgcagccac agccatctcc ccttccggca
    11101 cgtgggcccc tccctcgtcc ccgacctgga gctgccgttc gggacgacgc tgagcccgca
    11161 cctggagggt gcccgggtcc ggctcgtcga ctgggcccgc cggatgggca tcctggaggc
    11221 gcagccgggg atcccgggtt cgcacatctg ggacgaggac cggatcctcg cgatcgacct
    11281 ccccctctgc gcggcgggca tccacccgga cgcctcacct gacgagctgg acatctcctc
    11341 ggcatggctg gcctggggga cgtacggtga cgactggttc cccgtggtgc acgggcggac
    11401 cagggacctg gcgggggcgc ggctggccaa cgagcggctc tcgctcttca tgccgctgga
    11461 cggtgaggcc gccccggagc cggtcaacgc gctggagcgg tcgctcggcg acctgtggcg
    11521 caggaccgcg ggaccgatgg acccggacgc gcggcgcacc ttccggaccg cgatcgagtc
    11581 gatgaccgag agctggctgt gggagctggc caaccaggcg cagaaccgca tcccggatcc
    11641 ggtcgactac gtcgagatgc ggcgggcgac cttcggttcg gacctcacga tgagcctgtg
    11701 ccggctcggg cacggcagga cggtgccgga cgcggtctac cgcagtggcc cgatgcggtc
    11761 gctggagaac gccgcggcgg actacgcgtg cctgctgaac gacctgttct cgtaccagaa
    11821 ggagatcgag tacgagggcg aggtgcacaa cggcgtcctg gtcgtgcaga acttcttcgg
    11881 ggtcgactat ccgacgggcg tggccatcgt gcacgacctg atgaagtcgc ggctgcggca
    11941 gttcctgcac gtggcggagg tcgaactgcc ggtgctgtac gacgacttcg gcctggacgc
    12001 cgaggcgcgg gaggtgctgg cgggctatgt gcaggagctg aagcactggc tcgcgggcat
    12061 cctgatctgg caccggggct gccgccggta ccgcgaggag gacctgcggc gcggccacgg
    12121 cgccccctgg cacctcggcg gccccacggg gctcggcacc tcggcggctc aggtgacccg
    12181 gctgatggcc gagctggcgg gcagcagggg gtaggcagta ccgagcccgg ccgacggccg
    12241 gccgtgcgca cctcacggcc ggccgtcggc gtcctgtgcg caggcatcga atgcggcggg
    12301 gcaccacgag ggggcatgaa aaggccgcgg ccccacgagg gcatgggaag aggccgcccg
    12361 gcatattcgg gcggcctatg cagtgacgtt tcagccctgc tggaacagct ctgcgggcag
    12421 cggcttgagg agggtgtaga ggtcgtccgt gatgggccgg tcccagctgg cgatggtcac
    12481 gagcaccccg tcgctgcggt cgaactggac gcaggcgatc cggctctccg agagcttcac
    12541 ccggcggacg atcagcaggt tgtcgccctg catcacgggg acgtcctcgc tgctgacgac
    12601 ctcgatcggc tcgtcgttct ccagggccag caggagctgc gcgacctcga agggaacctg
    12661 gccgtcctcg gtctcgcggg cgggcgatcc ctccgggaga ttaccgatga tcatggccgg
    12721 gccgcggccg ccgtacaggt cgtaccggag gaagacgccc tggcagctgc cgtcgggcgc
    12781 ggggagcaga ccggcgccga ggttgccggg ccagtccccc gggtccatgg ccaggacatc
    12841 gaagtccggg cccgcgggtg ttgcggcgct acggcggcgg aggaaggaca tgctgccatg
    12901 ttacgtggcc cggctcacgt tgcggagccg ggcccggagc ggaacccggc cccggcgccc
    12961 gcgattccct ccggccaccg gcgggaatcg cggaccccgc tccggcggcg actcttccgc
    13021 gtggaatcgg cgcaagttcg cccgcccggg gctcccatga cgcataccgt tgggtccacc
    13081 gccctgcccc gcccgtcgag gcagcggcga gtgcggcgat gcgggtacgg cgacgggccg
    13141 ggagagagga caggatgacg gtggagggca ctgtgagcgg gctggaggag cgggcggtgg
    13201 ggcgcgcgtg gatggtgcgc ctggacccgg cggaccgggg cggtgcggcg gtacgcgtct
    13261 catgcggccg cccggcctgc gctcctcagg tcctgccctc cgccgccgtc ggccgcaccg
    13321 ccgccgtcgc ccacctggcg acgcatctgc gggcggccgc cgggccccgc cccgaggcgt
    13381 actgcgcctg ccgggccgag gagtgccaca cccacacccg ggagacgggt ccgcgtgagc
    13441 gggccacgcc gtcgcggtgc ggcggccccg tcgtgatggc cgtcatcaac gaccggcagg
    13501 gccgctggtg gcgggccctg gagtgctgcg cccggtgtgc ggccgcccac ccctccgcga
    13561 ggatcgtcgc caccgccccg gccgccgcga gcccggcccc cacgccagga gcccgtcccc
    13621 cggccggccg gccgcccgtc ccggccgggc cgcagttctc ccacgccgcc tcgtccccgg
    13681 ccgccgtccc ccgggcggtg cccgcccccc gcccgaagcc ccggcgcaac cgccggaccg
    13741 ggaagatcgc gcagcggatc gtgccgcacg atctgcaccc cgtcgccctg cgcgatgagc
    13801 tgatcgagtt gggcgacctc ttccgcgcct accagcagcg ccccgaaccg gacctggcgc
    13861 agctcgccga gctccactcc cgcaaggcgg tggccttcac gaggtggtgg gaggtcaccg
    13921 gtgagaccga tctgcggctg gaggcgcagc gcgcggagca ggcggccgcc gccgctctcc
    13981 tccagcacca gcagcgcacc ggccagagcc cggtcggcga cggcgaggtc accagccgcc
    14041 tgctgccggg gctcacgcag tgggaccacg cgcggacggt cctggcccat gtcgccgacc
    14101 acaccccgct gcccggcccc gaggcccgcc tgatggcggt ggtgctgacc ctgcgctcgg
    14161 cgctcaccgg cacgggcaac ctggtggggc aggacgtcaa ggggctgccc ctgacggagc
    14221 ccgaggagct gatcgggcgg ctcctggact ccggctggct gtccatcccc ggtaccgccg
    14281 acgatctgct cgcctcccgc cccgagagcc ccaccccgat caccatcccg tccctgatgc
    14341 ccgacgagga cggcgagggc ccgttcgact tcggcaggaa gacacgtccc aagctcagcg
    14401 gatgggccca gcgggtggtc ggggacagga agctccgcaa gaagaagacg ggggcggccg
    14461 tccggctcct cgccctggcc ctggcgatcc ggaccacgat cgacggacgg ctggggcccg
    14521 agggcgaggg catcgacacg gcggtcctca cctcctggtg tgccgtcgac tccggcgagc
    14581 tggaacccct ggtggagcag ctgaccgcgg cggactggct ggaggaggcc gccgtcaccg
    14641 acgggcgtct cacgggccgg ctcgccgagc gggtgctgcc gctcagctgc cccctgccct
    14701 gaagcccgcc cgcctcaccc cggcgggggc tgcgatccga cgagccacat ggcgaagaac
    14761 tgcgccccgc ccccgtaggc gtggccgacc gcccgggtgg ccccctcgat ctggtgctcg
    14821 cccgcccgtc cccgtacctg gagagccgcc tcggcgaagc ggatcatgcc ggacgcgccg
    14881 atggggttgg tggagagcac tccgcccgag gggttgaccg ggaggtcccc gtcgagttcg
    14941 gtgacgcccg cctcggtgag cttccacccc tcgccctccc cggcgaagcc gaggttctcc
    15001 agccacatcg gctcgtacca ggagaacggg acgtacatct cgacggcgtc gatctcccgg
    15061 cgcgggtcgg tgatccgggc ctgccggtag acgtcggccg cgcagtcctt gccggcctgc
    15121 ggggagacga agtccttgcc cgcgaagagc gtcggttcgc tgcgcatggc gccgccgtgc
    15181 acccaggccg gcgggtgcgg tgccctcctc gcgccctccc ggtcggtgag gatcatcgcg
    15241 caggccccgt cggaggaagg gcaggtctcg gagtagcgga tcgggtccca gagcatgggc
    15301 gaggcctgga ccttctccag ggtgatgtcc gggtcgtgga tgtgcgcgta ggggttcttg
    15361 agcgcgttgc ggcggtcctt gtacgcgacg agggagccga cggtgtcggg ggctcccgta
    15421 cggcgcatgt acgcgcgcac gtgcggggcg aagaagccgc cggccccggc cagcagcggc
    15481 tgctggaacg gcacgggcag cgagagcccc cacatggcgt tggactcgga ctgcttctcg
    15541 aaggcgaggg tcaggacggt ccggtggacg cgtgcggcga cgaggttggc ggcgacgagc
    15601 gcggtcgatc cgccgacgga gcccgccgtg tggacgcgga gcatcggctt gccgacggcg
    15661 ccgagcgcgt cggcgagata cagctccggc atcatgacgc cctcgaagaa gtcgggcgcc
    15721 ttgccgatga cgacggcgtc gatgtcgctc caggtcagtc cggcgtcggc cagggcacgg
    15781 accgccgcct cgcggacgag tccggcgatg gagacgtcgt gccgggcggc gacgtgcttg
    15841 gtctggccga tgccgacgac ggcgacgggc tccttaggca tgagcggtct ccccttccag
    15901 gacggcgacc aggttctgct ggaggcaggg cccggaggtg gcgtgggcga gggcccggtc
    15961 ggactcgccg cggtggatac gggcggcggc ctcgccgagc cggatgaggc ccgccgccat
    16021 gatcgggttg gcggcgagcg ccccgccgga cgggttgaca cgggtgtcgt cgccgagggt
    16081 gagggccttg cgcaggacga cctcctgcga ggtgaacggg gcgtgcaact cggctgtgtc
    16141 gacgggccgt tcgaaggccc cggcgtgctg ggcggcgagc cgggtggagg gcgagtcggt
    16201 cagatcgcgg acgccgaggc tgtgggcctc gatgcggtgg tcgatgcccc ggatccaggc
    16261 gggccgtgcg cacagggcgc gggcggtctc cccgacggcg aggatgacgg cggcggcgcc
    16321 gtcgccgatg ggcgggcagt cgccggtgcg cagggggtgc acgaggtggt cgcctgcggg
    16381 gacgtcgccg gtgagctggg cgtgcgggtt ggtggtggcg tcggcgcggc tgcgggcggc
    16441 gatggaggcc agggccgcct cgtcggtgtc gcccgcgtcg atgagggcct gcgcctggag
    16501 ggcggcgagt gcgacggagt ccggccagag cggggcgagg tagtacgggt cgagttggcg
    16561 ggtgaggacg tcgcggacct cgccgggcga ggacttgccg tacgagtaga ccagcgcggt
    16621 gtccgcctcg ccggtcatga tcttcaccca ggcctcgtac agcgcccagg ccccgtccat
    16681 ctcgacatgg gactcggaga tcggcgggtg ggcgccgacg ccgtcgaggg ccatcgtgaa
    16741 ggagaaggcg cgaccggcga ggtagtcggc ggagccggag caggtgaatc cgatctcgtt
    16801 ggccttcagc cccgtcgctc cgagcacctc gtggaggacg ggcatcagca ggtcgacctc
    16861 ggagagttcg tcggtgcgcc gccggtgcgc ggtctgggcg aaggcgacga tcgccacgtc
    16921 tcgcatctac accagctcct tgtacgtgtc gtagtcggca tcgggttcgc cggtgggccg
    16981 gtagtggtcg gggtgggcgg tgccctcagc ccagacgggc tcgacgcgca gccccatgcg
    17041 gacctggtcg tacgggatgc cggcgatgcg gccgtggagg gcgaggtcgg cgccgtcgag
    17101 ggcgatgtgg gcgtagacgt aggggacttc gatgtccagg ttcttcgctt tgatgttgac
    17161 gatgcagaag gtggtgacgg tcccgcgcgg tccgacctcg acctgttcgg cggtggcgat
    17221 gccgcaggtg gggcaggccc cgcgcggcgg tacgtagacc ttgcggcagg cggggcagcg
    17281 ttcgccgacg gtgcggtggc ctgcgagcgc cttgaggtag gcactctgcg cgcggcccgg
    17341 ggagtggacg tagtcgaggc gggcggcggc gacgatgccg gtgacggggt cggtgaactc
    17401 cccgtcgtgc ggcgcgggtt cgtcgggccc tgccgcaccg tcgtacggct cgaagcaggc
    17461 gatgtcggtg atggcgcccg tccgtgtcgc ggcccagcgg atacggaccc gcatcccggc
    17521 gtgcacggcg tcgggtccgg gcgcgtccaa cgcgtgcagg agggcggtgt ccgcgccgtc
    17581 gaggcggacg agcacccagg cgaacggagt ccccagcggc tggttgcggc ggggggacgg
    17641 gttccaggcc caggtggtga ccgtgccggt ggcggcgacc tcaacgagtt cgcggagctc
    17701 gttcgcggtg acggggtcgt actcgacggg cggtacgagg accgtgccct cgtcggtgcg
    17761 gacgcccagg acggtgcgtt cgcgcagccc ggtgaggaag gcgctctgga cggggccgag
    17821 ggaacgggtg aaggggaatt cgaccaccag cggggcgctg aggacgtcgg tcatggcact
    17881 ctccaaaggc tcagggctca ggcgcgccgg tagacgggcg ggcgcttctc ggcgaaggcg
    17941 cgggcgccct ccttggcgtc ctcggtggcg aacacgggcc agccgcgctt gagttcggcg
    18001 gccagcgcct cggtctcggt cagctcggca ccctcgtaga cggaggcctt gacggcctcg
    18061 acggcgagcg gcccgcaggc gttgatccgc tcggcgacgg cgagggcctc ctccagggcg
    18121 gtgccgtcgg gcacgacgcg gccgacgagc ccgatggcgc aagcctcgtc ggcggtgtac
    18181 ggacggccgg tgagcagcat ttcgagggcg tgggtgcggg ggatctggcg gggcagccgg
    18241 acggtggagc cgccgatcgg gaagaggccg cgccggacct cgaagagccc gaaggtggcc
    18301 cccgccccgg cgatacggat atccgttccc tggaggatct cggtgccgcc ggcgacacac
    18361 ggcccttcca cggcggcgat caccggtttg cgcgggcggt ggtggcggag catcgccttc
    18421 cagtggaggt ccgggtcggc ggccatccgc tcccggtact cctccccctc catcccgcca
    18481 cccgccagcg ccttgaggtc catgccggaa cagaacgcac cgcccgcccc ggtcagcacg
    18541 acggagcgca cctcgtcgtc ggcgtcggcc gcgagccacc cgtcgtacag gccgacgagc
    18601 atcggcagcg acaacgcgtt cctggcctgt ggtctgttca aggtgagcac cagcgtggcg
    18661 ccccggcgct ccacggtgag gtgttccgta ccgcccatga ccaactcccg tctgcagacc
    18721 tggaacaggt tgcagtaggc ggggtcgcag ttcaatagtt ttctgacagc tcgtcagatt
    18781 ctttcgacgg caccccttcc cacttgtgcc gcccggcgct ctaatgacgg ccgagtcgcc
    18841 agtcatccgg ggtcaggagg aacggtggag tacaaccttg ccgacctgtt cgagtcggtc
    18901 gtggacgtgg tccccgaccg cgaggcgctc ctgtacgtgg accatcccgg cacgggtgcc
    18961 gagcggcgcc tcacctacgc cgggctcgac gccgccgcca accggatcgc ccaccacctc
    19021 atcggtgcgg gcctccgccc gggcgaacat ctggggctgc acctctacaa cggcatcgag
    19081 tacctccaga cggtcctggg ggcgctgaag gcgcgcctgg tgccggtgaa cgtcaactac
    19141 cgctacgtgg aggaggagct ggtctacctc taccgggacg cggacctggc ggcgctggtc
    19201 ttcgacggcg agttcgacga gcgggtggca gcggcgtccg cgcaggctcc cggcctgcgc
    19261 cacctggtcc ggatcggacc cacagccgcg cccacgggcc tggaggccat gcccttcacc
    19321 gaggccgagg cgtccggatc ccccacacgc ggcttccaac cacgatccgc ggacgaccag
    19381 ttcatcatct acaccggagg cacgaccggg atgccgaagg gggtgatgtg gcgtcaggag
    19441 gacctgttct tctccggtct gggcgggggc gcgccgaccg gtgagccggt gaagagccca
    19501 caggagctgg cggagcgggt ggcggcgggc ggtgacggca tcactttctt ccccactccc
    19561 ccgctgatgc acggcacctc cacactgacc gccttcatcg ggttcaactt cggccaacgg
    19621 gtggtcgtgc accgcaagtt cgtccccgag gaggtgctgc ggacgatcga gagggagaag
    19681 gtcaccagcg tgtcgctggt gggcgacgcg atgctccgtc cgctgatcga cgccctcaac
    19741 ggtccgctgc gcgggacgga ctgctcgtcg ctgttctccg tctcaagctc cggggcgatc
    19801 atgtcggatt cggtgcgggc ggagttccag gcgctcgtgc cgaccgtgat gctgctcaac
    19861 aacttcggct cgtccgagtc cggcttcaac ggcacggcca ccgcggactc gggcccggag
    19921 cacggcttcc gggtccaggt caacgcccgt acggccgtgg tcgacccggc gacgtacgag
    19981 ccggtgacgc cgggtgaggt gggccgcatc gcccagcgcg gccatgtacc gctcggctat
    20041 tacaacgacc cggccaagac cgccgacacc ttcttccgca agggtgatga gcggtgggtg
    20101 ctgctgggcg acatggcgac cgtggacgcg gagggcatcg tcaccgtgct cggccggggc
    20161 tcgcagtgca tcaacaccgg cggggagaag gtctatccgg aagaggtgga gcaggcgctc
    20221 aagtcccacc cggacgtgta cgacgcgctc gtcgcgggcg tgccggacga gcgctggggc
    20281 agccgggtcg cggccgtcct cgaactgcgc gagggggcaa gggcgttgga cctcgaagcg
    20341 gtacaggccc actgccggac ccggctcgcc gggtacaaga tcccgcgcgc cctggtcctc
    20401 accgaccgga tccagcgctc gccgagcggc aaggcggact accgctgggc gaaggcggtg
    20461 gcggcggccg gcacagcggg gtgaggcggc cgggtcacag caggccgaac gacctgagcg
    20521 ccgcgaggaa ctcatccggc cgggtggtgt ggacgaggtg gcccgcctcg atggtggtga
    20581 acacggcgtc ggggatggtg tccgccatgc cggccagctg cttctggtcg atgtggctcg
    20641 tcgcgccgcc gccgatgatc agggtcgggg cggtgatctc ggccagccga tcgcggctcg
    20701 tcgggtccgg gtcgttcagc tgggcgtcgg tgtccgcgac cacgggccag tcgaagtcca
    20761 gctcgccttc cggccgttcg gaccgcggcc ggggcgggtc gagagggagg agcggcgggg
    20821 cgtcctcgat gaccagccgc ccgatgagcc cgggctcgcg ctgggccaga agataggcgg
    20881 ccaccccgcc catggagtgc gcgaccacgg tggcgccggc cagattgcgg gcctccagga
    20941 aggcgtgcag gtcgtcgcgg aagagttcga aggagtagcg gccgggccag tcactgagcc
    21001 cgtggccccg gaagtcgggg gcgtacacgc ggtgttcggc ggcgagctcc tcggcgacgc
    21061 gggtccaggt gagggaggag ccggcccggc cgtggaggag gacgacgggc ggtgccgacg
    21121 gctcgcccca gacccggtac gcgagccgga caccgcccgc gtgcacggtg aggacgtccg
    21181 ggtcgaggaa ggccgccacc gtacgggaga aggcgcccgg atcgtccagc cacgggaagt
    21241 gccccgcgcc ccgttggacg gtgaactcgc cgtacgggaa gagtgcggcc agctccgtcg
    21301 cccggtccgg gctcgggtgg ccgtcgtact ccccggcgag gacgagcacg gggacgggca
    21361 gcccgcgcag ggcggggacg gtggtggcgg gatcgtacgt gccgtcgccg tagcgaccgc
    21421 gcgcctcggg gttggtctgt ccggcggagg cggcggcgtg ggcccgggcg gcgtcgtccc
    21481 agcggccgta ggtgagtggc cggacggcgg gccacagctc ggcgaacggc ccgccggcga
    21541 gcagcgcctc ctgcgccgcc cgggcctcgg cgtaccaggg ttcgccactg cgcagttcgg
    21601 cggcctcgcg caggtcctgg tcggtcacct cgatgcccgc ggcccgggtg gagggggtga
    21661 tcagggtcag ggtgcgcagc cgctcggggt gccgggctgc gtacagctgg gccagatccg
    21721 cgcccgccga gtgggccagc aggtcgatcc ggtccaggcc gaggtgttcg cgcagggcct
    21781 ccacatcggc cacgagccgg tcgctacggt aggtcgaggg gtcctcgggt acggcggact
    21841 cccccgttcc gcgcagatcc agcaggacca gctgccgtac ggcggagagc ccgccgaggt
    21901 cgccgaggta ggcgctcgcc cgcatcggcc cgccgggcag gcagatgagc ggctcgccct
    21961 cccccaccag gtggtaggcg agctgggtgg tgtcgtacgc ggagaaggtc ggcatgccct
    22021 ccatccaaac aggagcgcgc cgacgaacgc acccggcttc gccgcgagcc gacccggaac
    22081 gggtccgtgc gcccctcttg ccagcgcccc cggcctcctg aattactgct cccaggaaga
    22141 tcgaccgaat gatcggtcgc ccggttcggg agaggatggg ccctgatgac agccatgctg
    22201 gacgcggcgg agca
//
