LOCUS       NZ_QZFU01000055        21074 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Nocardia panacis strain YIM PH 21724 NODE_8, whole genome shotgun
            sequence.
ACCESSION   NZ_QZFU01000055
VERSION     NZ_QZFU01000055.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardia panacis
  ORGANISM  Nocardia panacis
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 371932)
  AUTHORS   Miao,C.
  TITLE     YIM PH21274 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 371932)
  AUTHORS   Miao,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2018) Yunnan University, Yunnan Institute of
            Microbiology, 121, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 29.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003598715.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 03:06:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,880
            CDSs (total)                      :: 6,804
            Genes (coding)                    :: 6,707
            CDSs (with protein)               :: 6,707
            Genes (RNA)                       :: 76
            rRNAs                             :: 4, 5, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 4, 3 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 32 of 97
            Pseudo Genes (incomplete)         :: 82 of 97
            Pseudo Genes (internal stop)      :: 7 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:26:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 144891
            Orig. end                         :: 165965
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QZFU01000055.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11074
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(274..287)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     misc_feature    complement(1471..1482)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            2029..2601
                     /locus_tag="D5S18_RS33085"
                     /old_locus_tag="D5S18_33080"
     CDS             2029..2601
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013126708.1"
                     /locus_tag="D5S18_RS33085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33080"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_120045070.1"
                     /transl_table=11
                     /translation="MPKVSDDHLAARRSQILDGARGCFAEYGYDGATVRRLEETTGLSR
                     GAIFHHFRDKDALFLALAKEDAERMADVAANQGLVQVMRDMLADPAQFNWLGTRLEIAR
                     RLRTDPEFRANWEERSEELNAATLARLERRKAQGALRDDVPTDVLLGYLELVLDGLIAR
                     IASGHTSENLAAVLDLVEASVRRRADQ"
     gene            complement(2608..3120)
                     /locus_tag="D5S18_RS33090"
                     /old_locus_tag="D5S18_33085"
     CDS             complement(2608..3120)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019925654.1"
                     /locus_tag="D5S18_RS33090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33085"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_120045071.1"
                     /transl_table=11
                     /translation="MSEHRTDAVDAILAQWRAERPDLDLEAMAIVGRVGRLHQAAARAI
                     ESVFTEFGLQRGEFDVLAALRRAGAPYELNPSVLADTLMLSRAGMTGRLDRLESAELVR
                     RVGDTVDRRAIRVALTDKGRDLIDRAVTAHTANETRLLAALSAEDRRELDRIARILLHS
                     LEPGDQR"
     misc_feature    3160..3174
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            3191..3694
                     /locus_tag="D5S18_RS33095"
                     /old_locus_tag="D5S18_33090"
     CDS             3191..3694
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019047715.1"
                     /locus_tag="D5S18_RS33095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33090"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_120045265.1"
                     /transl_table=11
                     /translation="MTNESPDRAAAVCQPEDAEVRRTPEVRMRLLLDAPATGGSVSTLE
                     VTMGRGADGAVPHYHTKSDELFYVAEGELQVMAGDRIVTVGAGGAVSVPRFMPHAFGAA
                     PESSARILIALMPGVERFAYFRVLERLAAGEVTPTELIAAQEEFDNYFVEAPRWLDERN
                     ANRQ"
     gene            3803..4207
                     /locus_tag="D5S18_RS33100"
                     /old_locus_tag="D5S18_33095"
     CDS             3803..4207
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014350849.1"
                     /locus_tag="D5S18_RS33100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33095"
                     /product="thioesterase family protein"
                     /protein_id="WP_239004166.1"
                     /sec_met_domain="4HBT_2 (E-value: 2.9e-21, bitscore: 70.6,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVVVRGYELDTQGHLNQAVYLSYAEHARWELLRAAGLPQDKLIA
                     SGVGPVVLETTIKYRSELRGGDEVTISCEFGWASGKVFSMTQRVEKLDGTVSAEITVVA
                     GLLDLTARKLVLDPGERFRALAEQPELLGL"
     misc_feature    complement(3849..3864)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(4347..4361)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.4"
                     /tool="antismash"
     misc_feature    complement(4514..4526)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     gene            4545..4997
                     /locus_tag="D5S18_RS33105"
                     /old_locus_tag="D5S18_33100"
     CDS             4545..4997
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014350848.1"
                     /locus_tag="D5S18_RS33105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33100"
                     /product="hypothetical protein"
                     /protein_id="WP_120045073.1"
                     /transl_table=11
                     /translation="MTDAFHRSGIAPTGDRVPPLHGLLVGESECEITVRVAEGIWTFRR
                     DDVRLREGGTQSACAEGRPVMVDIRAGATADFTRRLRIDLVDRPLTLSEEPSEALGDEL
                     LQQLTASWADRLRLPGRADYTPATYTYCQTRSAGGSDDGINCDSLD"
     gene            5010..5969
                     /locus_tag="D5S18_RS33110"
                     /old_locus_tag="D5S18_33105"
     CDS             5010..5969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019047729.1"
                     /locus_tag="D5S18_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33105"
                     /product="hypothetical protein"
                     /protein_id="WP_120045074.1"
                     /transl_table=11
                     /translation="MAPGSVLIVSESADLHASAMTATLREQHGLTPIHLDLRDFPTEFG
                     SFRVDRLGTTRSLSHLIGLDEVGAVWWRRPHPSVVPAGVRAADDAYRQAECDAFIQGLL
                     WSIPALWVNDPGADRTAGRKIVQLETARRAGFAVPETLITNDPDEARGFVESRPGPVVY
                     KRTGTSRAEFSETRIIAATDYAKLAGIRSAPTTFQDYIAAECDLRVVWVDGVEWTVRID
                     SQAGVGRVDSRLDTSVEFRPDTLPASVSKSLATLMGALGLSFGVLDIRLGTDGEYYFLE
                     VNPQGQFAYLEIKTGLPIFQSLGNLLVHGDGAVPEWTD"
     gene            complement(5997..6230)
                     /locus_tag="D5S18_RS33115"
                     /old_locus_tag="D5S18_33110"
     CDS             complement(5997..6230)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014986328.1"
                     /locus_tag="D5S18_RS33115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33110"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_120045075.1"
                     /transl_table=11
                     /translation="MSDRPTSGKATLGKGTRVTGKSRDRLQSQLKKQYEAGASIRSLAR
                     ATGRSYGFIHNVLVESHVQLRSRGGANRRKSQ"
     misc_feature    complement(6302..6317)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(6386..8017)
                     /locus_tag="D5S18_RS33120"
                     /old_locus_tag="D5S18_33115"
     CDS             complement(6386..8017)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011559842.1"
                     /locus_tag="D5S18_RS33120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33115"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_120045076.1"
                     /transl_table=11
                     /translation="MITATDLEVRAGVRTLLSAPGPALRVQAGDRIGLVGRNGAGKTTT
                     LRILAGEGEPYAGAILRSSEIGYLPQDPREGNLDVLARDRVLSARGLDTLIRDMEKQQA
                     LMAEVADEAERDKAVRKYGRLEERFSALGGYVAESEAARICHSLGLPDRVLGQALRTLS
                     GGQRRRIELARILFSASDGSGGRSDRILLLDEPTNHLDADSITWLRGFLQSHDGGLIVI
                     SHDVELLDAVVNKVWFLDAVRGEADVYNMGWKKYLDARATDEQRRRRERANAEKKASAL
                     KAQAAKLGAKATKAVAAQNMVKRAERLMAELDDVRVADKVARIKFPSPATCGKTPLMAE
                     NLTKLYGSLEIFTGVDLAIDRGSRVVVLGLNGAGKTTLLRLLAGVEQPTAGGLVPGHGL
                     KIGYFAQEHDTLDDSASVWENIRHAAPDAGEQELRGLLGAFMFTGPQLEQPAGTLSGGE
                     KTRLALAGLVSSAANVLLLDEPTNNLDPISREQVLDALRSYTGAVVLVTHDPGAAEALN
                     PERVILLPDGAEDHWSKEYLELIQLA"
     gene            8192..8953
                     /locus_tag="D5S18_RS33125"
                     /old_locus_tag="D5S18_33120"
     CDS             8192..8953
                     /NRPS_PKS="Domain: PKS_KR (8-171). E-value: 4.6e-09. Score:
                     28.4. Matches aSDomain:
                     nrpspksdomains_D5S18_RS33125_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013415963.1"
                     /locus_tag="D5S18_RS33125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33120"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_120045077.1"
                     /sec_met_domain="adh_short_C2 (E-value: 6.3e-35, bitscore:
                     115.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDLIGKSALVSGASRGIGKAVAAELLRRGANVVITARKPEPLEE
                     AAADLRALGHRGEVVALAGNSGDAQSRADAVERAVSEFGSLDILINNTGINPVYGPLMD
                     ADLSAVRKIFDINVVAALGYIQEAHKAWMREHGGAVVNVASVTGLRSTGMIAAYGASKA
                     ALIRLTEELAWELGPNIRVNAVAPGVVKTKFADALYSADEERVAAGYPMKRLGVPEDVA
                     ELIGFLVSDSARWITGETVRVDGGLLATGVI"
     aSDomain        8216..8704
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D5S18_RS33125_PKS_KR.1"
                     /evalue="4.60E-09"
                     /label="D5S18_RS33125_PKS_KR.1"
                     /locus_tag="D5S18_RS33125"
                     /protein_end="171"
                     /protein_start="8"
                     /score="28.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVSGASRGIGKAVAAELLRRGANVVITARKPEPLEEAAADLRAL
                     GHRGEVVALAGNSGDAQSRADAVERAVSEFGSLDILINNTGINPVYGPLMDADLSAVRK
                     IFDINVVAALGYIQEAHKAWMREHGGAVVNVASVTGLRSTGMIAAYGASKAALIRLTEE
                     "
     CDS_motif       8219..8305
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_D5S18_RS33125_0001"
                     /evalue="2.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="D5S18_RS33125"
                     /protein_end="38"
                     /protein_start="9"
                     /score="16.9"
                     /tool="antismash"
                     /translation="LVSGASRGIGKAVAAELLRRGANVVITAR"
     gene            complement(8960..9937)
                     /locus_tag="D5S18_RS33130"
                     /old_locus_tag="D5S18_33125"
     CDS             complement(8960..9937)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D5S18_RS33130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="D5S18_33125"
                     /product="hypothetical protein"
                     /protein_id="WP_147404338.1"
                     /transl_table=11
                     /translation="MNGGRDDKVTQGNGPQPQDPANWWDQPIPPANPTPPTFDKSQPTV
                     ISQPPPSVARSSPTVQQPFPSPPPYQQPPAYPQPPAYQPNQAYQPSNPYYQANPVAPKS
                     NAGVFIGVVLGLVVLLGLGIGAVAYVTRDKESTNAAEDTFPTLPPETTFPPTNLPTPTF
                     GRPTGAPKSPTGARLGYAEYGGKDWDFKYADIALHADWVSGRDHDTCASIEKQGKLTAL
                     GCTYAAELVYKAEGGGLMLTQFILGMADADKAAAAMGKFSDRDLSLRKGTFVDNFTTGK
                     WKDGSQKSFVVITIATAKDAVDPALVQKYLHYRNADTLGALIWR"
     gene            10001..11074
                     /locus_tag="D5S18_RS33135"
                     /old_locus_tag="D5S18_33130"
     CDS             10001..11074
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019047734.1"
                     /locus_tag="D5S18_RS33135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33130"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_120045079.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.5e-48, bitscore:
                     160.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAQVLVVGLGPAGRALAHRCRTRGLAVVAVDPRPDRPWTATYAA
                     WRDELPEWLDPGAVAATVEAPVAWARREFRIDRPYSVLDSGRLRDSLSLAGAEIVADRA
                     VRLTRRAVTLASGRRLTADRVIDARGIPRSPRRAEQTAYGVLVEGSVCEPFFMDWRPDN
                     GADPEAPPSFLYAVPLAAGTMLLEETCLAGRPALSHSVLRERLIRRLRSRAIPFTEEVV
                     ERVRFPVQGARPARHAFGAAGGFTHPATGYSVAATLCAADAVAAGDSPASLSARAVHAL
                     RIAGLRTLLTLPPADIPLFFELFFELPAEQQRAYLSGRSDLPGTAAAMRALFAAAPARV
                     RRVMAHSLAPENGFGHD"
     gene            11078..11971
                     /locus_tag="D5S18_RS33140"
                     /old_locus_tag="D5S18_33135"
     CDS             11078..11971
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011210024.1"
                     /locus_tag="D5S18_RS33140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33135"
                     /product="Ku protein"
                     /protein_id="WP_120045080.1"
                     /transl_table=11
                     /translation="MARAIWKGSIAFGLVNVPVKVYTATEDHDIRFHQVHAKDGGRIKY
                     DRVCAVCGNSVQYADIDRAYESPEGDKVVLTEEDFAKLPAAEKHEIPVLQFVPSDQIDP
                     ILYDRSYYLEPDSSTPKAYVLLAKTLEHIDRTALVHFTLRQKTRLAALRVREGMLVLQT
                     LLWPDEVRSVEFDSLVDVAEPRPQEISMAETLVATMSDDFDPSLYTDEYQIELQKVLDE
                     AIASGTGKVTPRAEVAPAGLDAEVVDLVAALQRSLEASGRRAAAGESAAKPAAKKAAKK
                     AAPKKAVKKPAARKGA"
     gene            12078..12428
                     /locus_tag="D5S18_RS33145"
                     /old_locus_tag="D5S18_33140"
     CDS             12078..12428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019930342.1"
                     /locus_tag="D5S18_RS33145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33140"
                     /product="hypothetical protein"
                     /protein_id="WP_120045081.1"
                     /transl_table=11
                     /translation="MSINVDRRPIIACAAAGLVVLAVAGGLDRILLGTFVCVGLALGLV
                     NAWLTRIGVARATGSGTGYLAALSNLRLLVVTVVALAVGVLARPDGLGILFGLMAFQLA
                     AAAWTTASRATG"
     gene            12473..13147
                     /gene="atpB"
                     /locus_tag="D5S18_RS33150"
                     /old_locus_tag="D5S18_33145"
     CDS             12473..13147
                     /EC_number="7.1.2.2"
                     /GO_component="GO:0000276 - mitochondrial
                     proton-transporting ATP synthase complex, coupling factor
                     F(o) [Evidence IEA]"
                     /GO_component="GO:0045263 - proton-transporting ATP
                     synthase complex, coupling factor F(o) [Evidence IEA]"
                     /GO_component="GO:0045264 - plasma membrane
                     proton-transporting ATP synthase complex, coupling factor
                     F(o) [Evidence IEA]"
                     /GO_function="GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA]"
                     /GO_process="GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /gene="atpB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018599072.1"
                     /locus_tag="D5S18_RS33150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33145"
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="WP_239004167.1"
                     /transl_table=11
                     /translation="MEFHVDTIAATAVAAVAVLALAFLLRLRLTSGVPNGVQLFFETVT
                     VQMRGQVESAVGLRIAPFVLPLAVTLFVFVLLSNWLSVLPVQYGGGELIAPPAADVNFT
                     YALALFVFVGYQVAGMARRGPLGHVKQVLKGHMGWGPMVLINVIEELAKPLSLALRLFG
                     NMFAGGVMISVIALLPAWLSWGPNAAWKLFDLFVGLIQAFIFALLTVLYFGQATASEHE
                     NH"
     gene            13177..13437
                     /gene="atpE"
                     /locus_tag="D5S18_RS33155"
                     /old_locus_tag="D5S18_33150"
     CDS             13177..13437
                     /EC_number="7.1.2.2"
                     /GO_component="GO:0045263 - proton-transporting ATP
                     synthase complex, coupling factor F(o) [Evidence IEA]"
                     /GO_function="GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /gene="atpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014987510.1"
                     /locus_tag="D5S18_RS33155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33150"
                     /product="ATP synthase F0 subunit C"
                     /protein_id="WP_120045082.1"
                     /transl_table=11
                     /translation="MAAVTHETIVQAAALVAGGLMMVGGAIGAGYGNGMAGSALINGIS
                     RQPEAEGKLRGNYLMAVSLVDAVYFINLTFMALFAFATPGK"
     misc_feature    13438..13453
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.3"
                     /tool="antismash"
     gene            13443..13895
                     /locus_tag="D5S18_RS33160"
                     /old_locus_tag="D5S18_33155"
     CDS             13443..13895
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019930345.1"
                     /locus_tag="D5S18_RS33160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33155"
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="WP_120045267.1"
                     /transl_table=11
                     /translation="MTEHRAGQNFLLPDGTFFVELAIFLIVFGVIRIWVVPPVREVLAQ
                     RAARVAQTTANQARAQSISAEAAHRYRSAVTAAGAEAARMCAQARKEGQALVHATREEQ
                     QRRTDAMVADATARLRTDAAESALRFGAHLDPLAGRLADRVLGGRR"
     gene            13892..14422
                     /locus_tag="D5S18_RS33165"
                     /old_locus_tag="D5S18_33160"
     CDS             13892..14422
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012645.4"
                     /locus_tag="D5S18_RS33165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33160"
                     /product="hypothetical protein"
                     /protein_id="WP_120045083.1"
                     /transl_table=11
                     /translation="MTDDRSGLYDITWDWPVFLSQLFGFAVIVGVLAKWVLPPVRTAMR
                     RAQDTIDTQMADSAKASVDLAAAERAFAAAVHAAEAEVARIHREAREDAEGILAGLRET
                     AATETIRVRRAGLRNLSRTRDRLEAELAGDLTTAVLDRTESILRERLESPEAKAESIDL
                     FLAELADGLAEEA"
     gene            complement(14426..15913)
                     /locus_tag="D5S18_RS33170"
                     /old_locus_tag="D5S18_33165"
     CDS             complement(14426..15913)
                     /NRPS_PKS="Domain: Abhydrolase_1 (93-267). E-value:
                     5.2e-17. Score: 54.2. Matches aSDomain:
                     nrpspksdomains_D5S18_RS33170_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019044618.1"
                     /locus_tag="D5S18_RS33170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33165"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_120045084.1"
                     /sec_met_domain="PF00561 (E-value: 1.6e-21, bitscore: 71.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRDVFRRWAGLGAALILAGSVAGCGSAAEVNGLERLQRQQLRWQ
                     PCGDEKLDAAGAECADVTVPLNYAEPQGRTITVAISRARAADSARRHGVLISNPGGPGA
                     SGLDTALLEDEIQSGGLRERYDLIGMDPRGIGRSTPMHCDWPTPSGLRAAGLDRAGFEK
                     TLALHADLAARCRETGDAYRYITTRNTARDMDLIRAVLGEQRISYIGTSYGTYLGSVFA
                     QMFPDRIDRLVLDSAIDPVRYSVGMIQQMGKPNEVAFDVWAGWVAARDGEYHLGATASA
                     VRAKITELLRRSAREPITVGAQRVEAHELPLILFEGVAGSQGYVSLAVQLRQLLDAAEG
                     RAQAPDSELEQTLRDEWGPGSDSAVEMMIQCGDAPAPRDPDWYWRNLEASRATEPLFGS
                     YANHPSVCAFWPAPVEPPTVIGNALPSLILQSVMDTRTAYEEGIALHGMMTGSRLVTMP
                     DKVAHGVLDKSACARAVAAGYLRTGVLPEADMTCAAG"
     aSDomain        complement(15113..15634)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_D5S18_RS33170_Abhydrolase_1.1"
                     /evalue="5.20E-17"
                     /label="D5S18_RS33170_Abhydrolase_1.1"
                     /locus_tag="D5S18_RS33170"
                     /protein_end="267"
                     /protein_start="93"
                     /score="54.2"
                     /tool="antismash"
                     /translation="VLISNPGGPGASGLDTALLEDEIQSGGLRERYDLIGMDPRGIGRS
                     TPMHCDWPTPSGLRAAGLDRAGFEKTLALHADLAARCRETGDAYRYITTRNTARDMDLI
                     RAVLGEQRISYIGTSYGTYLGSVFAQMFPDRIDRLVLDSAIDPVRYSVGMIQQMGKPNE
                     VAFDVWAGWVA"
     gene            complement(16085..16951)
                     /locus_tag="D5S18_RS33175"
                     /old_locus_tag="D5S18_33170"
     CDS             complement(16085..16951)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014986337.1"
                     /locus_tag="D5S18_RS33175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33170"
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_120045085.1"
                     /transl_table=11
                     /translation="MRILRRVLAISALLALAATGVACGEQHSSDVVRIGVNDLSLPHWD
                     VYKKKAAEQGIKVELINFTDYNQPNPALSQGQIDLNKFQHLRYLANYNARNNDTLVPIG
                     ATEIYPLTLYSKKHKNVADIPKGGQITLSNNPANQVRPLLSLAAAGLIVLKGGPTWDSK
                     IEDVDTGASKVRLNTIDPTLTAQSLDSVDAAFVDDAFARPAGLGKKETIYSDDPERPDL
                     KQYINIFATRAVEKDNPKYRKLAELYHDPEVEAAIRAEKDYDGTFKTNSQADLQSTLID
                     LESKFRK"
     gene            17088..17963
                     /locus_tag="D5S18_RS33180"
                     /old_locus_tag="D5S18_33175"
     CDS             17088..17963
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016882930.1"
                     /locus_tag="D5S18_RS33180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33175"
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_120045086.1"
                     /transl_table=11
                     /translation="MKFHRALAIPVLVATAALTLAACGSEDKTSSDTVVRIGTTDNDHT
                     WEVFEQRAKEQGINLKVTTFSDYKQPNLALSQKQIDLNLFQHIQFLGDYNVANNDDLTP
                     IGSTYIVPLGVYSKKHKTLAEIPQGGEIAIPNDPTNQARALFVLRSAGLVKLAGEVAQP
                     TPADVDKAASKVKVTAVDAAQTALSLASVDASVINNTFLDRSGIDPNSALYKDDPKDAG
                     AEPYINVVVARKADRDNPLYQRVVDLWHDPAVQRAHAETTKSTSVEVKRTPAELEQILA
                     RVQQTARKSK"
     gene            17969..18997
                     /locus_tag="D5S18_RS33185"
                     /old_locus_tag="D5S18_33180"
     CDS             17969..18997
                     /EC_number="7.4.2.11"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014986339.1"
                     /locus_tag="D5S18_RS33185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33180"
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="WP_120045268.1"
                     /transl_table=11
                     /translation="MSEQPPAVEFRSVTKVFGKGADRHVALDGIDLRIEKGEIFGVIGY
                     SGAGKSTLVRLINALERPTSGTIEVGGAPITGTSEAGVRRLRREIGMVFQQFNLFRSRT
                     AAGNIEYPLKVAGWKRAERKARVAELLEFVGLTDKARSYPDQLSGGQKQRVGIARALAT
                     SPALLLADESTSALDPETTAEVLRLLKKINRELGVTIVVITHEMDVIRAVADRVAVLAE
                     GRIVELSSTFDVFANPQATPTRSFVATVLHDRPSDTELARLRDKHGGRMVTVDIDDERG
                     LGAALAAATRADVRFEVVFGGVSTLQDKTFGSVTLALHGSDDAVDEVAAALDRRERNSG
                     AH"
     gene            18987..19649
                     /locus_tag="D5S18_RS33190"
                     /old_locus_tag="D5S18_33185"
     CDS             18987..19649
                     /EC_number="7.4.2.11"
                     /GO_function="GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005057738.1"
                     /locus_tag="D5S18_RS33190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33185"
                     /product="methionine ABC transporter permease"
                     /protein_id="WP_120045087.1"
                     /transl_table=11
                     /translation="MHTDWDKLRPVLFESIGDTIYLVSVAFVVGGVIGLFLGTALYTTR
                     RGGLLANAPVNVLLNVLVNVVRPIPFIILLAALGPVTLQVVGTTIGRDAAAFVMIVAAS
                     FGVARIVEQNLVTVDPGVIEAARACGAGPLRIIATLLIPEALGPLILGYTFVVIAIVDM
                     SAMAGTVGGGGLGNFALVYGYQRFNWQATFVAMLIIVIGVQGVQFFGNWLARKVLRR"
     gene            complement(19651..20073)
                     /locus_tag="D5S18_RS33195"
                     /old_locus_tag="D5S18_33190"
     CDS             complement(19651..20073)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025197.4"
                     /locus_tag="D5S18_RS33195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33190"
                     /product="DUF4189 domain-containing protein"
                     /protein_id="WP_120045088.1"
                     /transl_table=11
                     /translation="MSLLGRAALIVVASAVAGIVDAGGASAEPGADGRLYGAMAVEVVG
                     DEVHTIWASDFPSWADADASVLGRCSSANCNVIVRFVDGCGSIAAKKGAMIGRSAPTKA
                     EAEQAAVDAFGPPVTSFSAAPPRANILRTECTSNAE"
     misc_feature    complement(20065..20067)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20114..20539)
                     /locus_tag="D5S18_RS33200"
                     /old_locus_tag="D5S18_33195"
     CDS             complement(20114..20539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011210087.1"
                     /locus_tag="D5S18_RS33200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_33195"
                     /product="DUF4189 domain-containing protein"
                     /protein_id="WP_120045269.1"
                     /transl_table=11
                     /translation="MSLLRNSVLGVAVASAAALGVLAAGTAEAAGTLFGTVTISPGTGK
                     VGLSTDQRSWVAADAEAQRQCGEYDCQIQLRYSDGCAAVARGADGRFGWAAAGSRQEAE
                     ETAVAGLGESAPPFPDLGSASPRAAAVVAAACTENVR"
ORIGIN
        1 ctgggcaata tgagtccgga attcggttcc accgccgcga tcttcccgat cgactcggtg
       61 accgtggact acctgcgcct caccggccgc agcgacgagc aggtcgcgct cgtcgaggcc
      121 tacgccaagg aacagggcct gtggcacgac gccgactccg agcccgccta ctcggagtac
      181 ctggagctcg acctgggcac cgtggtgccc tcgatcgcgg gtccgaagcg tccgcaggac
      241 cgaatcctgc tctcggagag caagatcgcc ttccgcaagg acatccacaa ctacacctcc
      301 gatcccgagg gcgccccgca ctcgcatctg gacgaggcga tcgaggagtc cttcccggcc
      361 agcgacgcgc cggtgctgtc cttcgccgat gacgacgcgg tgctgcccac ggccgccaac
      421 ggttcgacgg gccgcccgac caagccggtc aaggtgcaca ccgacgagta cggcgatttc
      481 gtgctcgatc acggcgcggt cgtggtcgcc tccatcacct cctgcaccaa cacctccaac
      541 ccgtcggtca tgatcggcgc ggccctgctg gcccgcaacg cggtggagaa gggtctgacc
      601 cgcaagccat gggtgaagac ctcgatggcc cccggctcgc aggtcgtcaa cggctactac
      661 gagaaggcag gtctgtggcc gtacctggac aagctgggtt tcaacctggt cgcgttcggc
      721 tgcgccacct gcatcggcaa caccggcccg ctgccggagg agatctccaa ggcggtcaac
      781 gacaacgacc tgagcgtcac ggcggtgctc tcgggcaacc gcaacttcga gggccgcatc
      841 tcccccgatg tgaagatgaa ctacctggcc tccccgccgc tggtcatcgc ctacgcgctg
      901 gccggaacca tggacttcga cttcgagcac gacgcgctcg gcacggattc cgagggcaac
      961 gaggtcttcc tgaaggacat ctggcccgcc ccgcaggaga tccaggacac catcgaccgg
     1021 gtcatctccc gcgatatgtt cctcgaggac tacaaggacg tcttcaaggg cgatgagcgc
     1081 tggcgcggcc tgccgacccc cgagggcaag accttcgact gggacgcgca gtccacctac
     1141 gtgcgcaagc ccccgtactt cgacggtatg ccgcagaccc cgaagccggt cgcggacatc
     1201 aagggtgcgc gggtgctggc gctgctgggc gattcggtca ccaccgacca catctccccc
     1261 gcgggcaaca tcaagccggg caccccggcc gcgcagtacc tggaggccaa tggcgtcgag
     1321 cgcaaggact acaactccta cggctcgcgg cgcggcaacc acgaggtcat gatccgcggc
     1381 accttcgcca atatccggct gcgcaaccaa ctcctcgacg acgtctcggg cggttacacc
     1441 cgcgacttca ccctggaggg cggcccgcag gcgttcatct acgacgcctc gcagaactac
     1501 caggccgcag gcgtcccgct ggtggtgctc ggcggcaagg aatacggttc gggctcctca
     1561 cgtgactggg cggccaaggg caccagcctg ctgggcgtgc gggccgtgat caccgaatcg
     1621 ttcgagcgca tccaccgctc caacctcatc ggcatgggcg tggtcccgct gcagttcccg
     1681 acgggcgaat cggccgcgtc gctgaagctg gacggcaccg agaccttcga tatcgagggc
     1741 atcgccaagc tgaacgaggg cgtcaccccg aagacgctga aggtcaccgc caccaaggag
     1801 aacggcgagg tgatcacctt cgacgcggtc gttcgcatcg acacccccgg tgaggcggac
     1861 tactaccgca acggtggcat cctgcagttc gtgctgcgca acatgatcaa ggcgtaacct
     1921 cgccggagat catcgacgtg cgcttccccg ctgccttcgc cgcagtgggg aggcgcacga
     1981 tttcgtcttg gtgcttttcg acccgcacca tcgagtacgg aggctttatt gcccaaggtc
     2041 agtgacgacc acctcgcggc ccgccgctcc cagatcctcg acggggcgcg cggttgtttc
     2101 gccgaatacg gctacgacgg tgcgacggtg cgacggctcg aggagaccac cggtctgtcg
     2161 cgcggcgcca tcttccacca tttccgcgac aaggacgcgc tgttcctggc cctggccaag
     2221 gaggacgcgg agcggatggc cgatgtcgcc gccaatcagg gtctggtcca ggtgatgcgc
     2281 gatatgctcg ccgacccggc ccaattcaat tggctgggta cgcgtttgga gatcgcgcgg
     2341 cggctgcgca ccgatccgga gttccgggcc aactgggagg aacgctccga ggagttgaac
     2401 gcggccaccc tggcccgcct ggagcggcgc aaggcgcagg gcgcgctgcg cgacgatgtg
     2461 cccaccgatg tgctgctcgg ctacctggag ttggtgctcg acgggttgat cgcccggatc
     2521 gcctcgggac acaccagtga gaatctggcg gccgtcctgg acctggtgga agcgtcggtg
     2581 cgccgccgag cggatcagta ggcgcggcta ccgctgatcc cctggttcca ggctgtgcag
     2641 caggatccgg gcgatgcggt cgagttcgcg gcggtcctcg gccgatagcg ccgcgagcag
     2701 gcgggtctcg ttggcggtgt gcgcggtcac cgcgcggtcg atcaggtcgc ggcccttgtc
     2761 ggtgagggcg acgcggatgg cgcggcggtc gacggtatcg ccgacgcggc gcaccagttc
     2821 ggccgattcg agccggtcga ggcggccggt catacccgcg cgggacagca tgagggtgtc
     2881 ggcgaggacc gaggggttga gttcgtaggg cgcgcccgcg cggcgcagcg cggccagcac
     2941 atcgaattcg ccgcgctgca acccgaattc ggtgaagacc gattcgatgg ccctggcggc
     3001 cgcctggtgc agtcgaccga ctcggccgac gatcgccatg gcctccaggt cgaggtcggg
     3061 gcgctcggcg cgccactggg cgaggatcgc gtcgacggcg tcggtgcggt gttcggacat
     3121 ggacggattc tattcgatga catatagttt ggtcgcgaac tatcaatcag cgaatcactt
     3181 ggagtcggtc atgaccaacg aatcccccga ccgagccgcc gccgtctgcc aaccggagga
     3241 cgccgaggtg cgtcgcacac ccgaggtccg aatgcgacta ctactcgacg cccccgccac
     3301 cggcggatcg gtgagcaccc tcgaggtgac catgggacgc ggcgccgacg gcgccgtccc
     3361 gcactaccac accaaatccg acgagctgtt ctacgtggcc gagggcgaac ttcaggtcat
     3421 ggccggtgac cggatcgtca ccgtcggcgc gggcggcgcg gtgagcgtgc cccgcttcat
     3481 gccgcacgcc ttcggggccg caccggaaag ctcggcccgc atcctcatcg cgctcatgcc
     3541 cggcgtcgaa cgcttcgcgt atttccgggt gctggaacgc ctcgccgccg gggaggtcac
     3601 acccaccgag ctgatcgcgg cccaggagga gttcgacaac tacttcgtgg aggcgccgcg
     3661 ctggttggac gagcgcaacg ccaaccggca ataaatgaca gagccggtaa tgcccgtcgg
     3721 gccgcggctg tggcccacct atcagcgtcg atccggaaca ttcggttcgc accgtgcggt
     3781 tgacccggtt atgacgttct tcgtgcccgt cgttgtccgc ggctacgagc tcgataccca
     3841 gggccacctc aaccaggcgg tctacctgag ctacgccgag cacgcccgat gggagctgct
     3901 gcgggcggcg gggctgccac aggacaagct gatcgcctcg ggcgtcgggc cggtagtgct
     3961 ggagaccacc atcaagtacc gcagcgagct gcgcggtggg gacgaggtca ccatcagctg
     4021 cgaattcggt tgggccagtg gcaaagtctt ctcgatgacg cagcgggtcg agaagttgga
     4081 cggcacggtg tcggcggaga tcaccgtggt ggccggacta ctcgatctga cggcgcgcaa
     4141 gctggttctc gatccgggcg agcggttccg cgccttggct gagcagccgg agctgctcgg
     4201 actgtaggtc cggaattgtc ggcgcgagaa tgccacagcg ggtaggggac ccggcgctac
     4261 gagcgcgaaa gcgcctggcg taagcgcgaa cgcgcttaca ggtgaacggc cgccaactcg
     4321 cggctaaacg atcaggtcct ctcgtttgaa aatagctgtc aaattgcttc cggatggttt
     4381 cccggtcatc gaaaatcttt cggcgctagc gcatcccacg cccagatcgg gtttgccggc
     4441 cgctgtgaaa tctcccgata ccgtccaaac ggaccccggt gcgcgctatg atccagagca
     4501 cgctcggggg tcctggcaaa tcgcgagcag atcggagaca gcttatgacc gacgcattcc
     4561 accgctccgg aatcgccccg accggtgacc gcgtcccacc gctgcacggt ctactcgtcg
     4621 gggagtccga gtgcgagatc accgtccgcg tcgccgaggg catctggact ttccgccgcg
     4681 acgacgtccg gctgcgcgag ggcggaacgc aatccgcctg cgccgagggc cgccccgtca
     4741 tggtcgacat ccgcgcgggc gcgacggccg atttcacccg ccgcctgcgc atcgacctgg
     4801 tcgaccgccc gctgaccctc tccgaggagc cctccgaggc gctgggcgac gaactgctgc
     4861 aacaactcac ggcttcctgg gccgacaggc tgcgcctgcc cggtcgcgcg gattacaccc
     4921 ccgccaccta tacctactgc cagaccaggt cggccggggg cagcgacgac ggcatcaact
     4981 gcgacagtct cgactgagcg gattcgacga tggcaccggg ttcggtcctc atagtgtccg
     5041 aatcggcgga tctgcacgcc tcggcgatga cggcgacgct gcgagaacag cacgggctca
     5101 ccccgattca cctggacctg cgcgacttcc ccacggaatt cggcagtttc cgggtcgatc
     5161 ggctcggcac cacccgctcg ctgtcgcatc tgatcggttt ggacgaggtg ggcgcggtgt
     5221 ggtggcggcg gccgcatccg agcgtggtgc ccgcgggggt ccgggccgcc gacgacgcct
     5281 accggcaggc cgaatgcgat gcgttcatcc agggtctgct gtggtcgatt ccggcgctgt
     5341 gggtcaatga tccgggtgcg gatcgcacgg cgggccgcaa gatcgtccag ttggagacgg
     5401 cgcgacgcgc gggcttcgcc gtcccggaga cgctcatcac caatgatccg gacgaggcca
     5461 gggggttcgt cgaatcccgg cccggcccgg tggtttacaa gcgcaccggc accagccgcg
     5521 ccgaattctc cgagactcgg atcatcgcgg cgaccgatta cgccaagctg gcgggtatcc
     5581 gctccgcgcc caccaccttc caggattaca tcgccgccga atgcgatctg cgcgtggtct
     5641 gggtcgacgg ggtcgagtgg acggtgcgca tcgactcgca ggccggggtg ggccgggtgg
     5701 attcccggct cgacacctcg gtggagttcc gccccgatac cctgcccgcc tcggtcagca
     5761 agtcactggc caccctgatg ggtgcgctcg gattgtcctt cggcgtcttg gatattcggc
     5821 tcggcacgga cggcgagtac tacttcctgg aggtcaaccc gcaggggcag ttcgcctatc
     5881 tggagatcaa gaccggtcta ccgatcttcc agagcctcgg caacctcctg gtgcacggcg
     5941 acggcgctgt cccagagtgg acggactgag ccgcgcctcg attcgcgcgc cgaaacctat
     6001 tggctcttgc gacgattcgc gccacctcgg ctgcggagtt gcacatgcga ctccaccagc
     6061 acgttgtgga tgaagccgta ggagcgcccg gtcgcccgcg ccagcgagcg aatgctcgcc
     6121 cccgcctcgt attgcttctt cagctgggac tgtagacggt cacgcgactt gccggtgacg
     6181 cgcgtgccct tacccaatgt ggccttgcct gatgtgggcc tgtcgctcat ggctatcctc
     6241 cgagtcgccg agcagcgtct ttccaggcta ggttgtccgc aggccgtgat caacgggtca
     6301 ctgtgatgaa actcacctac ggcgaagaag ttccgaattt cccggcgtgg cgtgcgagtg
     6361 tcgcgctgcc ccgccggatt acggatcagg ccaactggat gagttccagg tactccttgg
     6421 accagtggtc ctcggcgccg tcgggcagca ggatgacgcg ctcgggattg agcgcctcgg
     6481 ccgcgcccgg atcgtgggtc accaggacca ccgcgcccgt gtagctgcgc agcgcgtcga
     6541 gcacctgctc gcgggagatc ggatccaggt tgttggtcgg ctcgtcgagc agcaggacat
     6601 tcgccgccga ggagaccaga cccgccaggg ccagacgcgt cttctcacca cccgacaggg
     6661 tgcccgcggg ttgctccaac tggggaccgg tgaacatgaa cgcgccgagc aggccgcgca
     6721 actcctgctc ccccgcatcg ggggcggcat ggcggatgtt ctcccagacg ctggccgaat
     6781 cgtcgagggt gtcgtgctcc tgggcgaagt agccgatctt caggccgtga ccgggaacca
     6841 gcccgcccgc cgtgggctgt tcgacgcccg cgagcaggcg cagcagcgtc gtcttgcccg
     6901 cgccgttgag tccgagcacc accacccgac tgccgcgatc gatggccagg tcgacaccgg
     6961 tgaagatctc cagcgagccg tacagcttcg tcaggttctc ggccatgagc ggggtcttgc
     7021 cgcaggtggc cgggctcggg aatttgatcc tggccacctt gtcggccacg cgcacatcgt
     7081 ccaactcggc catcaggcgc tcggcgcgct tgaccatatt ctgcgcggcg acggccttgg
     7141 tggccttcgc gccgagtttg gcggcttggg ccttgagcgc gcttgccttc ttctccgcgt
     7201 tggcgcgctc gcggcggcgg cgctgctcat cggtggcgcg ggcgtcgaga tacttcttcc
     7261 agcccatgtt gtagacatcg gcctcgccgc gcaccgcgtc gaggaaccac accttgttga
     7321 ccacagcgtc gagcagttcc acatcgtggc tgatgacgat caggccgccg tcgtggctct
     7381 gcaggaagcc gcgcaaccag gtgatggagt cggcgtcgag gtggttggtc ggctcgtcga
     7441 gcagcaggat gcgatcggag cggccgccgc tgccgtcgga ggccgagaac aggatgcggg
     7501 ccaattcgat gcggcgacgc tgaccgcccg acagggtgcg cagcgcctgc ccgagcaccc
     7561 ggtccggtag gccgaggctg tggcagatgc gggcggcctc gctctcggcg acgtagccgc
     7621 cgagagcgga gaagcgctcc tcgaggcggc cgtacttgcg gaccgcctta tcccgctcgg
     7681 cctcgtcggc cacctcggcc atcagcgcct gctgcttctc catatcgcgg atcagggtgt
     7741 ccaggccgcg cgcggagagc accctgtcgc gggccagcac atcgagattg ccctcgcggg
     7801 gatcctgcgg gaggtagccg atctcgctgg agcgcaggat ggcgcccgcg tacggctcgc
     7861 cctcgcccgc caggatccgc agcgtggtgg tcttgcccgc gccattgcgc ccgaccaggc
     7921 cgatccggtc gcccgcctgc acccgcagcg ccggaccggg ggccgagagc agggtgcgga
     7981 ctccggcccg gacctccagg tcggtcgcgg tgatcacaga tatctcctaa aaggcggcgc
     8041 gtgctgagcg gtagcgggtt tacttcagta gggtgcgcgg gtcggcgcac acgaacaacc
     8101 gattttacct gtgccgcacc aacagaccgc attcgcgcgg tgtgaccgcg gctacgatcg
     8161 cgcgcggacg gttcagtaac gtgccttgag tatgaacgat ctgattggca agagcgcgct
     8221 ggtctccggg gccagccggg gcatcggcaa ggcggtggcg gccgaactgc tgcgccgcgg
     8281 cgcgaatgtg gtgatcaccg cgcgcaaacc ggaaccgctg gaggaggccg ccgcggacct
     8341 gcgggcactc ggccatcgcg gcgaggtcgt cgccctcgcg ggcaattccg gcgatgcgca
     8401 gagccgggcc gacgccgtcg agcgggctgt ttccgagttc ggctcgctgg acattctcat
     8461 caacaacacc ggcatcaacc cggtctacgg gccgctcatg gacgccgacc tgagcgcggt
     8521 ccgcaagatc ttcgacatca acgtggtcgc ggccctcggc tatatccagg aggcgcacaa
     8581 ggcgtggatg cgcgagcacg gcggcgcggt ggtgaatgtc gccagcgtca ccgggttgcg
     8641 ctccaccggg atgatcgccg cctacggcgc gtccaaggcc gcgctcatcc ggctcaccga
     8701 ggaactcgcc tgggaactcg gcccgaacat ccgggtcaac gcggtcgcgc ccggcgtggt
     8761 gaagacaaaa ttcgccgacg cgctctactc ggccgacgag gagcgggtgg cggcgggcta
     8821 tccgatgaag cggctcggcg tgcccgagga tgtggccgaa ctgatcgggt tcctggtctc
     8881 cgactcggcg cgctggatca ccggggagac ggtgcgcgtc gacggcgggt tgctcgccac
     8941 gggcgtcatc tgagcaggct cagcgccaga tcagtgcccc gagggtgtcg gcgttgcggt
     9001 agtgcaggta cttctgcacc agggccggat cgacggcatc cttcgcggtg gcgatggtga
     9061 tcaccacgaa ggacttctgg ctgccgtcct tccacttgcc ggtggtgaag ttgtccacga
     9121 aggtgccctt gcgcaggctc agatcccggt cgctgaattt gcccatggcg gccgcggcct
     9181 tgtcggcgtc ggccatgccg aggatgaact gggtcagcat gagtccaccg ccctcggcct
     9241 tgtagaccaa ctcggccgcg taggtgcagc cgagggcggt gagtttgccc tgcttctcga
     9301 tcgaggcgca ggtgtcgtgg tcgcgacccg acacccagtc ggcgtgcagg gcgatatcgg
     9361 cgtatttgaa atcccagtcc ttgccgccgt attcggcgta gccgagtctg gcgccggtcg
     9421 gggatttggg tgcgccggtg ggtctgccga aggtcggtgt cggcaggttc gtcggcggga
     9481 aggtcgtttc cggggggagg gtcgggaagg tgtcctcggc ggcgttcgtg gattccttgt
     9541 cgcgggtgac gtaggcgacc gcgccgatac cgaggccgag gaggacgacc aggccgagca
     9601 ccacgccgat gaatacgccc gcgttcgact tgggcgcaac gggattggct tggtagtacg
     9661 ggttggacgg ttggtaggcc tgattcggtt ggtaggccgg gggttgcgga taggcgggcg
     9721 gctgctggta gggcggcggc gaaggaaagg gctgctgcac tgtggggctc gatctggcga
     9781 ccgagggtgg cggctgggaa atcacggtcg gctgcgactt gtcgaatgtc ggcggggtcg
     9841 gattcgcggg gggtatcggt tgatcccacc agttggcggg gtcttggggt tgcggtccgt
     9901 tgccctgcgt caccttgtca tcccttccgc cattcatcgg accacacgct accgggccgg
     9961 taacggtgcc ataggctcgc ccggaccgag ggaggacgcg atgcgcgcgc aggtgcttgt
    10021 cgtcgggctc ggccctgccg gacgggcgct ggcgcaccgg tgtcggaccc gcggcctcgc
    10081 tgttgtcgcg gtggacccgc gtccggatcg accgtggacc gcgacgtacg ccgcgtggcg
    10141 cgacgaactg cccgaatggc tcgatccggg tgccgtcgcc gcgaccgtcg aggcgccggt
    10201 ggcgtgggcg cggcgggaat tccgaatcga ccggccgtat tcggtgctcg attccgggcg
    10261 gctgcgggac tcgctgagtt tggcgggtgc ggagatcgtc gcggaccggg ccgttcggct
    10321 gacgcgacgt gcggtcactc tcgcctcggg gcgacgactc accgccgacc gggtgataga
    10381 tgctcgcggt atcccgcgtt cgccccgccg ggccgagcag accgcctacg gcgtcctcgt
    10441 cgaaggaagc gtctgcgaac catttttcat ggattggcga ccggacaacg gcgccgatcc
    10501 cgaggcgccg ccctcgttcc tctacgccgt tccgctcgcc gcggggacca tgctgctgga
    10561 ggagacgtgc ctcgccggac gtcccgcgct gagccattcg gtgctgcgcg agcggttgat
    10621 acgccgattg cggtcccgtg caataccttt caccgaggag gtggtggagc gagttcgttt
    10681 tccggtgcag ggtgcacgac ccgcgcggca tgcgttcggc gcggcgggcg gattcaccca
    10741 tcccgcgacc ggatacagcg tcgccgcgac cctttgcgcc gccgatgccg tcgcggcggg
    10801 cgactccccc gcttcgcttt ccgcccgcgc ggtccacgcg ctgcgaatcg ccggactgcg
    10861 tacgctgctc accctgccac ccgccgatat tccgctgttc ttcgagttgt tcttcgagct
    10921 tcccgccgaa cagcagcggg cgtatctttc ggggcgctcc gatctaccgg gtacggccgc
    10981 cgccatgcgg gcgcttttcg ccgccgcgcc cgcgcgggtg cggcgcgtca tggcgcattc
    11041 gctcgcgccg gagaatgggt tcggccatga ttgagcaatg gcacgagcta tttggaaggg
    11101 ctcgattgcg ttcgggctgg tcaatgtccc ggtcaaggtc tacaccgcga ccgaggatca
    11161 cgatattcgc ttccatcagg tgcatgccaa ggacggcggt cgcatcaaat acgacagggt
    11221 gtgcgcggtc tgcggaaact ccgtgcagta cgccgatatc gatcgcgcct acgaatcccc
    11281 cgagggcgac aaggtcgtat tgaccgagga ggatttcgcg aaactgcccg ccgcggaaaa
    11341 gcacgagatc ccggtcctgc agttcgtgcc gtcggatcaa atagatccca tcctctacga
    11401 ccgcagctac tatttggagc ccgattccag tacaccgaaa gcgtatgtgt tgctggcgaa
    11461 gacgctcgaa cacatcgatc gcaccgcgct ggtgcacttc acgctgcggc agaagacgcg
    11521 gctggcggcg ctgcgggtgc gcgaggggat gctcgtgctg cagacgctgc tgtggcccga
    11581 cgaggtgcgc tcggtggaat tcgactcgct ggtggatgtg gccgaaccgc gcccgcagga
    11641 gatctccatg gccgagacgc tggtggcgac catgtccgat gatttcgacc cgagcctcta
    11701 caccgacgag tatcagatcg aactccagaa ggtgttggac gaggcgatcg ccagtggcac
    11761 cgggaaggtg acaccgcgcg ccgaggtcgc gcccgccgga ctcgatgccg aggtggtcga
    11821 tctggtggcg gcgctgcagc gcagtctgga ggcgagtggt cgccgggccg ccgcaggcga
    11881 gtccgcggcg aagcccgccg cgaagaaggc ggccaagaag gccgctccga agaaggcggt
    11941 caagaagcct gcggcgcgca agggcgcctg accgggtcgc accagattct tttgtcctct
    12001 atgtcccatt ccttcggttc ttgtactaca tttggtagta ggcgcgggag cgtcaactca
    12061 tcgccgaggg agggcagatg tcgatcaacg tcgatcgccg cccgatcatc gcctgtgccg
    12121 cagcgggact cgtggttctc gccgtggccg gggggctgga tcggatactt ctagggacat
    12181 tcgtctgcgt cggactcgcc ttggggctgg tcaacgcctg gctcacccgg atcggggtgg
    12241 cccgcgcaac cggttccggc actggatatt tggcggcact gtcgaatctt cgactgctcg
    12301 tcgtcaccgt ggtcgcgcta gccgtcgggg tgctagcacg accggacggg ttgggaatcc
    12361 tcttcggact catggcattc cagctcgccg ccgccgcgtg gaccaccgct tcgagggcca
    12421 ccggatgacg aaaatcgaag tgggacacca tgaaatcgcg cgtctatggg gaatggaatt
    12481 tcatgtcgac accatcgcgg ccaccgccgt cgcggcggtc gccgtactcg cgctggcctt
    12541 tctgctgcgc ctgcggctga cctccggcgt ccccaacggg gtgcagttgt tcttcgagac
    12601 cgtgaccgtg caaatgcgcg gtcaggtgga aagcgctgtg ggactgcgca tcgcgccctt
    12661 cgtcctaccg ctggcggtca cgctgttcgt gttcgtcctg ctgtcgaact ggctgtcggt
    12721 gctgcccgtg cagtacggcg gcggcgagtt gatcgcaccg ccggcggcgg atgtcaactt
    12781 cacctacgca ctggcactgt tcgtcttcgt cggctaccag gtcgccggca tggcgcggcg
    12841 cggaccgctc ggacatgtca agcaggtgct caaagggcat atggggtggg gaccgatggt
    12901 gctcatcaat gtcatcgagg agttggccaa accgctctcg ctggcgctgc ggctgttcgg
    12961 gaatatgttc gcgggcggcg tgatgatctc ggtgatcgcc ctgctgcccg cctggctcag
    13021 ctggggcccc aatgccgcct ggaaactgtt cgacctgttc gtcgggctga tccaagcatt
    13081 catcttcgcg ctgctgaccg tcctgtattt cggccaggcc accgcgtccg aacacgagaa
    13141 ccactgagct tcaacttcaa agaggaagga aaacccatgg cagcggtgac ccacgagacg
    13201 atcgtccaag cggcggcact ggtcgcgggc ggactcatga tggtcggcgg cgcgatcggc
    13261 gcgggctacg gcaatggcat ggcgggatcg gcgctcatca acggcatttc ccggcagccg
    13321 gaggccgaag gcaagctgcg cggcaactat ctcatggcgg tcagcctggt cgacgccgtg
    13381 tatttcatca acctgacctt catggcactg ttcgcgttcg cgacgcccgg caagtgaacg
    13441 ccatgaccga acatcgagcg ggacagaact ttctgctgcc cgacggcacc ttcttcgtcg
    13501 aactggcgat cttcctgatc gtcttcggcg tcatccggat ctgggtggtg ccacccgtcc
    13561 gggaggtgct ggcgcagcgc gcagcacgcg tcgcgcagac caccgcgaat caggcacggg
    13621 cacagtcgat ttccgccgag gccgcacatc gataccgcag cgcggtcacg gcggcggggg
    13681 ccgaggcggc gcggatgtgc gcacaggcga gaaaggaagg acaagcgttg gtgcacgcga
    13741 cgcgcgagga acaacagcgc cgaaccgatg ctatggtcgc cgatgccacc gcgcgactgc
    13801 gcaccgacgc cgccgaatcg gcgctccgat tcggcgcgca cctcgatccg ctggcaggca
    13861 ggctggccga tcgcgtactc ggaggacgac gatgaccgac gaccgcagcg gactctacga
    13921 catcacctgg gactggccgg ttttcctcag ccagctgttc ggattcgccg tcatcgtcgg
    13981 ggtgctcgcg aagtgggtcc tcccgcccgt gcgaaccgcc atgcggcgcg cgcaggacac
    14041 catcgacacc caaatggccg acagcgcaaa ggcttcggtc gacctcgcgg ccgccgaacg
    14101 cgccttcgcc gcggccgtgc acgcggccga ggccgaggtc gctcgcatcc accgcgaggc
    14161 ccgcgaggac gccgagggca tcctcgccgg tctgcgggag accgcggcga ccgagaccat
    14221 ccgggtgcgg cgtgcgggtc tgcggaacct gtcgcggact cgcgaccggc tcgaggccga
    14281 actcgcgggc gatctgacca cggcggtcct ggaccgcacc gagtcgatcc tgcgggaacg
    14341 cctcgaatcg cccgaggcca aggccgagag tatcgatcta ttcctcgccg aactggccga
    14401 cggtctcgcc gaggaggcgt agcgctcagc ccgccgcgca ggtcatatcg gcttccggga
    14461 ggacgccggt gcgcagatag cctgcggcca ccgcacgcgc gcacgcgctc ttgtccagta
    14521 cgccgtgcgc caccttgtcc ggcatggtga ccaatcggga accggtcatc atgccgtgca
    14581 gggcgattcc ctcctcgtag gcggttcggg tgtccatgac cgactgcagg atcagcgagg
    14641 gcagcgcgtt gccgatgacg gtgggcggtt ccaccggagc gggccagaac gcgcagacgc
    14701 tggggtgatt ggcgtaggag ccgaagaggg gttcggtggc gcgactggcc tcgagattgc
    14761 gccaatacca gtccgggtcg cgcggggcgg gcgcgtcgcc gcactggatc atcatctcca
    14821 cggcgctatc ggaacccgga ccccactcat cgcgcagggt ctgctccagt tcgctgtccg
    14881 gggcctgcgc ccggccctcg gccgcgtcga ggagttggcg cagctgaacc gccaacgaca
    14941 cgtagccctg gctccccgcg accccctcga acaggatcag cggcaattcg tgcgcttcga
    15001 ctcgctgcgc gccgacggtg atgggttcgc gcgcggaccg ccgcagcagt tcggtgatct
    15061 tggcgcgcac cgccgaagcc gtggcgccca agtgatattc gccgtcccgc gccgccaccc
    15121 acccggccca gacatcgaag gcgacctcat tgggtttgcc catctgctgg atcatgccga
    15181 cggaatagcg gaccggatcg atggcgctgt cgagtaccag gcggtcgatg cggtccggaa
    15241 acatctgcgc gaaaacggat cccagatagg tgccgtagga ggtgccgata tagctgatcc
    15301 gctgttcgcc gagcaccgcg cgaatcagat ccatatcgcg cgcggtattg cgggtggtga
    15361 tgtagcggta ggcatcgccg gtctcgcgac agcgcgctgc cagatccgcg tgcagcgcga
    15421 gggttttctc gaaacccgcc cggtcgagtc ccgccgcccg cagtcccgag ggcgtcggcc
    15481 aatcgcagtg catcggggtg gaacgaccga tccctcgggg atccattccg atcaggtcgt
    15541 agcgctcacg caaaccgccc gactgtattt cgtcctcgag cagggcggta tcgagtccgg
    15601 acgcgccggg accgccggga ttggagatca gcacgccgtg ccgccgcgcc gaatccgcgg
    15661 cgcgggcgcg cgagatcgcg accgtgatcg tgcgtccctg cggctcggcg taattcagcg
    15721 gaacggtgac atcggcgcac tccgcgcccg ccgcgtccaa cttctcgtcc ccgcacggct
    15781 gccaccgcaa ctgctggcgc tgcaaccgct ccagaccgtt gacctcggcc gccgaaccgc
    15841 acccggccac cgatcccgcg agaatcagcg ccgcgcccag ccccgcccac cgtcgaaaaa
    15901 cgtctcgtcc caccggattc ctcttcgctc gcccgtgcga tcaaccctag aatcccgacg
    15961 aatcggacac atccttcgaa cgcctacccc cgcgacgacc tccgacgtac ccccgctacc
    16021 cactttcggc catcggtgga cagacgtggc gcgccgagtg ccctggggca ctcggcgcgg
    16081 gcggctactt gcggaatttg gattcgaggt cgatgagggt ggattggagg tcggcctggg
    16141 agttggtttt gaaggtgccg tcgtagtcct tctcagcgcg gatggcggct tccacttcgg
    16201 ggtcgtggta gagctcggcc agtttgcggt atttggggtt gtccttctcg acggcgcggg
    16261 tggcgaagat gttgatgtac tgcttgaggt cggggcgttc cgggtcgtcg gagtagatgg
    16321 tctctttttt gccgagaccg gcgggacggg cgaaggcgtc gtcgacgaag gcggcgtcca
    16381 cgctgtcgag ggattgggcg gtgagggtgg ggtcgatggt attcagtcgc accttggacg
    16441 cgccggtgtc gacatcctcg atcttggaat cccaggtggg tccgcccttg aggacgataa
    16501 gacccgccgc ggccagactc agcagcgggc gcacctggtt ggccggatta ttgctgaggg
    16561 tgatctgacc gcccttgggg atatcggcga cgttcttgtg cttcttcgaa tacaaagtga
    16621 gcgggtagat ctcggtcgcg ccgatcggca ccagcgtatc gttgttccgc gcgttgtaat
    16681 tggccagata gcgcagatgc tggaatttgt tcagatcgat ttggccttgg gacagcgccg
    16741 gattgggctg gttgtagtcg gtgaaattga tgagctccac cttgatgccc tgttcggcgg
    16801 ccttcttctt gtagacatcc cagtgcggca gggagagatc gttcacaccg atgcgcacca
    16861 catcggagga gtgttgttca ccacaggcca caccggttgc cgcgagggcg agtagagccg
    16921 aaatcgccag cacacggcgc agaattcgca ttgccagcaa gctagccgaa acaatcgcct
    16981 cggtaaaggg tttccctcga ggcaatcgca actgttgccg gacggatgct cgaaccgctt
    17041 ggattaccgg gttcataggc attgcgacaa gcattacagg agcacgtgtg aaattccatc
    17101 gggcactggc gatcccggtc ctggtagcta cggccgccct caccctggcg gcatgcggct
    17161 ccgaagacaa gacctcctcc gacacggtag tgcgcatcgg caccactgac aacgatcaca
    17221 cctgggaggt cttcgagcag cgggccaagg agcagggcat caacctgaag gtgaccacct
    17281 tctccgatta caaacagccc aatctcgcgc tgtcgcagaa gcagatcgat ctgaacctct
    17341 tccagcacat ccagttcctc ggcgactaca acgtggccaa caacgacgat ctgaccccga
    17401 tcggctcgac ctacatcgtg ccgctgggcg tgtattcgaa gaagcacaag acgctggccg
    17461 agatcccgca gggcggtgag atcgccattc cgaacgatcc gaccaatcag gcccgcgcgc
    17521 tgttcgtgct gcgctcggcc ggactggtga aactcgcggg cgaggtcgca cagccgaccc
    17581 cggccgatgt ggacaaggcc gcctccaaag tgaaggtgac ggccgtcgac gccgcgcaga
    17641 ccgcgctgtc gctggcctcc gtggacgcct cggtcatcaa caacaccttc ctcgatcgtt
    17701 cgggtatcga ccccaattcg gccctgtaca aggatgatcc gaaggacgcg ggcgccgagc
    17761 cctacatcaa tgtggtggtc gcccgcaaag ccgacaggga caacccgctc taccagcgcg
    17821 tggtcgacct gtggcacgac ccggcggtgc agcgggcaca cgccgagacc accaagagca
    17881 cctcggtcga ggtcaagcgc accccggccg aactcgagca gattctggcg cgagtgcagc
    17941 agaccgcgcg caagtcgaag tgagccaggt gagcgagcag ccgcccgccg tcgaattccg
    18001 gtccgtcacc aaggttttcg gcaagggcgc ggatcggcac gtggcgctgg acgggatcga
    18061 cctgcgcatc gagaagggtg agatcttcgg cgtcatcggc tattccggcg cgggcaaatc
    18121 caccctggtg cgtctgatca acgcgttgga gcggccgacc agcgggacca tcgaggtcgg
    18181 gggcgcgccg atcaccggga cgtccgaagc cggtgtgcgc cgcctgcgcc gcgagatcgg
    18241 catggtgttc cagcagttca acctgttccg atcccgcacg gccgcaggca atatcgaata
    18301 tccgctgaag gtggcggggt ggaaacgcgc cgaacgcaag gcgcgggtgg ccgaactgct
    18361 ggaattcgtc ggcctgaccg acaaggcgcg cagctatccc gatcaactct ccggtgggca
    18421 gaagcagcgg gtcggtatcg cccgcgcgct ggccaccagc ccggcgctgc tgctggccga
    18481 cgaatccacc tcggcactgg atccggagac caccgccgag gtgctgcggc tgctgaagaa
    18541 gatcaatcgg gaactcggcg tcaccatcgt ggtcatcacc cacgagatgg atgtgattcg
    18601 cgcggtggcc gatcgggtcg cggtgctcgc cgagggccgg atcgtcgaat tgtcgagcac
    18661 cttcgacgtt ttcgcgaacc cgcaggcgac gccgacccga tcgttcgtgg cgaccgtcct
    18721 gcacgatcgg ccctccgata ccgaactggc gcggttgcgc gacaagcacg gcggccgaat
    18781 ggtcaccgtc gacatcgacg acgagcgcgg tttgggcgcc gccctggccg ccgccacccg
    18841 cgccgacgtg cgcttcgaag tggtgttcgg tggtgtgagc accctgcagg acaagacatt
    18901 cggcagtgtc acgctggccc tgcacggctc ggacgacgcg gtggacgagg ttgccgccgc
    18961 actcgaccgc agggaaagga actccggtgc acactgattg ggacaaactg cgaccggtgc
    19021 tgttcgaatc catcggcgac accatctatc tggtgagcgt cgccttcgtg gtgggcgggg
    19081 tgatcggcct gttcctcggc accgccctct acaccacccg ccggggcgga ctgctggcca
    19141 acgcgccggt gaacgtactg ctcaatgtgc tggtgaatgt ggtgcggccg attccgttca
    19201 tcattctgct ggccgcgctc ggcccggtga cgctgcaggt ggtcggcacc acgatcggta
    19261 gggatgccgc cgccttcgtc atgatcgtcg cggcctcctt cggggtcgcg cgcattgtcg
    19321 agcagaacct ggtgaccgtg gatcccggcg tcatcgaggc ggcccgcgcg tgcggggccg
    19381 gaccgctgcg gatcatcgcg accctgctca tcccggaggc gctggggccg ctgatcctcg
    19441 gctacacctt cgtggtgatc gccatagtcg acatgtcggc catggcgggc acggtcggcg
    19501 gcggcggact gggcaatttc gccctggtct acggatatca gcgcttcaac tggcaggcca
    19561 ccttcgtggc gatgctgatc atcgtcatcg gggtgcaggg cgtccagttc ttcggcaact
    19621 ggttggctcg gaaggtgttg cgccgctgat ttactcggcg ttgctggtgc attcggtgcg
    19681 caggatgttg gcgcgcggcg gcgccgcgct gaacgaggtg accggcggac cgaaggcgtc
    19741 gacggcggcc tgttccgcct ccgccttggt gggggcggaa cggccgatca tggccccctt
    19801 cttcgccgcg atcgacccgc agccgtcgac gaagcggacg atcacattgc agttggcgga
    19861 actgcaccgt ccgagcaccg aggcgtcggc gtcggcccaa ctcggaaagt cggaggccca
    19921 gatggtgtgc acctcatcgc ccaccacctc caccgccatg gccccgtaga ggcggccatc
    19981 cgcccctggt tcggcggacg cgccgcccgc gtccactatc ccggcgaccg cggacgcgac
    20041 aacgatcagg gcggctctgc ccagtaaaga cattgcgagg atcttcccgt ctaactcatg
    20101 gggacgtgtg aactcagcgg acgttctcgg tgcaggccgc cgccacgacg gccgcggcgc
    20161 gtggcgaggc gctacccaag tcgggaaagg gcggggcgct ctcgcccaag cccgccaccg
    20221 ccgtctcttc cgcctcctgg cgcgaacccg ctgcggccca accgaatcgg ccgtccgcgc
    20281 cgcgggcgac ggcggcacag ccgtcgctgt agcgcaattg gatctggcag tcgtattcac
    20341 cgcactgtcg ttgcgcctcg gcatcggcgg ccacccaact ccgctgatcg gtggacagac
    20401 ccaccttgcc ggtgcccggt gagatggtga cggtgccgaa cagcgtgccc gccgcctcgg
    20461 ctgtcccggc cgcgagcaca ccgagggcgg cggccgaggc caccgcgacg ccgagaaccg
    20521 aattgcgcag tagcgacacc acaatctccc catctcacga agaccgacgg ctcgatcatg
    20581 gtcgagcccg cgagacctgt ccagtatccc gttgccgctc aggggaattc cctaccgtga
    20641 gcaacaatgc gccaagccgg acgcatccgg tttttcgctc atgccaactc ccggtatgga
    20701 ccgcgatcga tcgccaggta gaccgcattg cgcagcgcat tggcctcggc ggttcgcccg
    20761 cgcggatgcg atccaccacg tcctgactcg gatcgggtgg gagaaccccc ggtccgatga
    20821 ccaccgcagg gacctacgtg tggttgcgca cgtatgagcc ccggcggccg actatcggcc
    20881 gggggcgcat aaatcgctgc gtcatcacca cattcgaaag tgtacagaaa cgacggccgc
    20941 cgaattctcc ggcggccgtc gctgtatcgc gaggatcaaa cggtgaaccc gagtgcgcgc
    21001 aactgttcgc gcccgtcctc ggtaatcttg tcgggacccc acggcggcat ccagacccag
    21061 ttgatcttga gatc
//
