LOCUS       NZ_QZFU01000014        22452 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Nocardia panacis strain YIM PH 21724 NODE_15, whole genome shotgun
            sequence.
ACCESSION   NZ_QZFU01000014
VERSION     NZ_QZFU01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardia panacis
  ORGANISM  Nocardia panacis
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 228830)
  AUTHORS   Miao,C.
  TITLE     YIM PH21274 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 228830)
  AUTHORS   Miao,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2018) Yunnan University, Yunnan Institute of
            Microbiology, 121, Kunming 650091, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 29.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003598715.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 03:06:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,880
            CDSs (total)                      :: 6,804
            Genes (coding)                    :: 6,707
            CDSs (with protein)               :: 6,707
            Genes (RNA)                       :: 76
            rRNAs                             :: 4, 5, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 4, 3 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 32 of 97
            Pseudo Genes (incomplete)         :: 82 of 97
            Pseudo Genes (internal stop)      :: 7 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:26:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 186198
            Orig. end                         :: 208650
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QZFU01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22452
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22452
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lassopeptide"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22452
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12452](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12452
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(154..1233)
                     /locus_tag="D5S18_RS06995"
                     /old_locus_tag="D5S18_07000"
     CDS             complement(154..1233)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.4"
                     /locus_tag="D5S18_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07000"
                     /product="serine hydrolase"
                     /protein_id="WP_120038982.1"
                     /transl_table=11
                     /translation="MRWIRRLLTVLLVIVVAPAVLVTLLLVTVRGSVIGFIVDRSADEP
                     VTAAVLQVSDGRGTRVWHAGETVLPDTRFRIGSVTKTFVATVVLQMIDEKLLALDDPIE
                     QILPGVVPRGESVTIRQLLNHTSGLYDYMKEPGMSTNRWRGEDRFRHFDVARLLSVAFA
                     HPPYFAPGTRFRYSNTNYVVLGSVIEKVTGRPYADAIRTRILEPLGLRDTLFPGDDPTI
                     PAPLLPARSKLASGVTVDVTEQNPALDWSAGEMISSTSDLAVFFDALMSGRLLSASMLA
                     GMKQTVPMGLGFHYGLGVQRFDLPCGVRLWGHGGELLGYLTYVFVGPDERVMTMVLASA
                     QGDNFAVFAAAAAAVFCLR"
     cand_cluster    506..12386
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    506..12386
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5505:7386](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5506..7386
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            1506..2723
                     /locus_tag="D5S18_RS07000"
                     /old_locus_tag="D5S18_07005"
     CDS             1506..2723
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="D5S18_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07005"
                     /product="MFS transporter"
                     /protein_id="WP_120039055.1"
                     /transl_table=11
                     /translation="MDTARGRSSVRHDPKGIDAQADSPDKGWRARIAILALGSFAVGTD
                     GYVIVGLLPQIAGTLHVGIAASGQLVSVFALVYALMAPVLAALTGRWSRRRVLVTALAL
                     LGAGNAVTALAGDYALVLASRVVAGCGAALFSASAVATASHLAPQRRRGSAIAMVTTGA
                     TLALVLGAPMGTVIGDAWGWQSAIWFITVLAAVVAAAIAVLLPDIRLDPAATLRQRLAP
                     LTDMRVLRVLVVTLLGFVAIFLPFTYMSAVFAPAIDGRESRLALLLMVFGIAATVGNLT
                     AGRLADRYRPRFVVVGALAGIAVVFAIMPLVRDSFVLAVAVQALAGLVCFSVIGPQQHR
                     IIAHAPAGGAPVVTSLNLSTAYLGNFCAGALGAVLLSSGAAYVPAVAAAFALVAGLVAA
                     WGRDRR"
     gene            2778..3407
                     /locus_tag="D5S18_RS07005"
                     /old_locus_tag="D5S18_07010"
     CDS             2778..3407
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="D5S18_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07010"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_147403871.1"
                     /transl_table=11
                     /translation="MSEAMPVRAGSALDPDATRARVLDVAARLFYERSLAAVGMREVAT
                     ESNASQLTIYRYFGSKEGLAAAVVRERSDRTHAWLAEGLAEVPAGRARVLALFDMLNRW
                     FTEGDYRGCPVLNYAADSRGGTTDLAATRRHLERYRQLLEQLLTETGVPTPQTLARQLL
                     LLIEGATVVSQVDGPGPAGVDARAAAETLLDAAPTRASGTPAPQEK"
     gene            3572..3823
                     /locus_tag="D5S18_RS07010"
                     /old_locus_tag="D5S18_07015"
     CDS             3572..3823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013828201.1"
                     /locus_tag="D5S18_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07015"
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_120038984.1"
                     /transl_table=11
                     /translation="MKTIQQRDLRNYSGKVLAEVEAGESFTITRNGKPVAELRPLTQRT
                     FVPVAELARTSANLPRIDYNEWRADMDAMIDQETHGRE"
     gene            3816..4229
                     /locus_tag="D5S18_RS07015"
                     /old_locus_tag="D5S18_07020"
     CDS             3816..4229
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014348364.1"
                     /locus_tag="D5S18_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07020"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_120038985.1"
                     /transl_table=11
                     /translation="MSKLAAPRHVLLDTSVLIDYTDVRSTLPDEAEAAISAVSLAELAA
                     GLHSTRDPINQARRQLRFQWVAKSFNPLAFDAETANVYGSLAFLIDQIGRKPRGRIADL
                     QIAATAVQHSLPLYTRNPHDFKGLEPLLNVVAV"
     gene            complement(4522..4791)
                     /locus_tag="D5S18_RS34770"
     CDS             complement(4522..4791)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D5S18_RS34770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158607812.1"
                     /transl_table=11
                     /translation="MTATTTGTTTAGVAARATTPTARATAPTTSTTAMGRRCGELLDDD
                     LAEFWRLYQLIHFALLTVETRNFRHLTLSTGTTETYGVQAASNH"
     misc_feature    complement(4938..4954)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            5506..7386
                     /locus_tag="D5S18_RS07025"
                     /old_locus_tag="D5S18_07030"
     CDS             5506..7386
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="D5S18_RS07025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07030"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_203236636.1"
                     /sec_met_domain="YcaO (E-value: 4.4e-91, bitscore: 299.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.9e-78, bitscore:
                     257.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGAGFDAAAAALGMRVDAGDPDLRVVLTDDYLRGDLAEINRGRL
                     DDGGAWMLVKPVGSVVWIGPVFEPGRTGCWQCMSTYLETHQILRRYLRQRSGAGEPPVV
                     SVADLPATRRMAAEMAALHAAKWLAGFNPGEPGAGESVPAGPEIFTLNTARWHGQRHVL
                     HKRPQCPACGDPEIQQRLQRAPVRLGSRLKVVTSDGGHRASTPETLLSDYESMISPITG
                     PVPHLTPTSPAEGLHTYLAGANMAVAMADVGALRAGLRQSAGGKGMTDVQAKASALAEA
                     IERYSGVYRGDEATISATMSELGDAAIHPNALQLFSDRQFADRAAWNAKQLRNQHVCDP
                     FDPARRTEWTPVWSLSRDTTRHLPTAALFYGYPLPCGGWFAAADSNGNAAGSCVEDAVL
                     QGFLELVERDSVAVWWYNMVRRPGIDLASFDEPYFQRWQQRYRSIGRETWALDVTTDLG
                     IPTVVAVSRRVDQPQEDLVFAFGAHFDVKIAISRALTEMNQFLNLYTAATGELQHWLRS
                     ATVGNQPYLLSAEDQPLRVAADYRDPTTDDLAEDIALAQRIVENAGMELLVLDQTRPDI
                     GLPVVKVIVPGMRHFWTRYAPGRLYDVPVRLGWLSEPTPETELNPIGMFL"
     misc_feature    6700..6702
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7469..8725)
                     /locus_tag="D5S18_RS07030"
                     /old_locus_tag="D5S18_07035"
     CDS             complement(7469..8725)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF018485.4"
                     /locus_tag="D5S18_RS07030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07035"
                     /product="MFS transporter"
                     /protein_id="WP_120038987.1"
                     /transl_table=11
                     /translation="MSQHTTAEARSATIRTWLLALGMFAIGTDLFIVSGLLPALGHDLG
                     LSMSAAGQTVTVFAITYAVASPILTGLTARLDRRLLLGAVLAVFAAGNVLSAVAPDYSI
                     LLVSRFVAGLGAALYAVTASGTAARITAPERRGRALAIVYAGMTSAIALGVPIGDAIGN
                     ALSWRWAFGFVAALAVATGIGLVVSLPALPGTTGIGLRERVSAIRIRRAPTALTITMLW
                     VVGTFVTYTYLGSIFDSVTHVALGDRPWLLLLFGIGSFAGVLGGGRLADRVNPTAGLAC
                     SIGLLILVLAALGIAFRSTPGAAIGVAVWGLVHWVSFPLIQHRLIGIGGKHADMLLALN
                     NSAVYLGQTIAAVVGGLLTDLGALAALPFAGAGFELIALVLLAVSAGSRPRSADPIDAH
                     RQSMAERGGSAQQLSEDRT"
     gene            8787..9368
                     /locus_tag="D5S18_RS07035"
                     /old_locus_tag="D5S18_07040"
     CDS             8787..9368
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018984.4"
                     /locus_tag="D5S18_RS07035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07040"
                     /product="ABATE domain-containing protein"
                     /protein_id="WP_158607813.1"
                     /transl_table=11
                     /translation="MDAEEVRDWVWYGGRVSVDFVNTRRDRYAGGRELLEHPSDLDAWF
                     TTAQLIPCRAEVAEELLREARQLREAIDAGIRSVVGSEPFDAGARDVINNWLARANHPP
                     RLELSDGLPILRMDDAPTDATGALYRIALDAAQLLGSDTRSRIRICAGAECSGRFVDLS
                     VAGRRRWCRMSVCGNRAKAAQHRRSARSQH"
     misc_feature    9451..9465
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    9685..9699
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.19"
                     /tool="antismash"
     misc_feature    complement(9723..9736)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.04"
                     /tool="antismash"
     misc_feature    9817..9831
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.39"
                     /tool="antismash"
     gene            9845..9997
                     /locus_tag="D5S18_RS34775"
     CDS             9845..9997
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="D5S18_RS34775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_158607814.1"
                     /transl_table=11
                     /translation="MEQNKVRTSDRRAENVESYEPPLLVDAGEFTERTRGGTDKYREAS
                     IGRFL"
     misc_feature    complement(9878..9894)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            10001..11779
                     /locus_tag="D5S18_RS07045"
                     /old_locus_tag="D5S18_07050"
     CDS             10001..11779
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="D5S18_RS07045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07050"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_120038990.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.1e-33, bitscore:
                     111.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWFAALPDNAAGRDMVARFPDSARRIAAHGSGLPWLIGSLPPEQ
                     CTIVESGSARLAVLGYCPSTAVALAEQLVRIRGLADLDALAGALRGSCHLVLSLDGNTR
                     VQGTVSGLRRVFYARCAGRVVAADRADVLAGATSAEPDELWLTAAVLGPDLPHPLADRT
                     AWRGIEAVPADSALHLDARGQARLRRWWTPPEPTLSSADGAQALRTELRDAVAARTRRA
                     SAPVGCDLSGGMDSTALCFLASRGDPVAVTVHYRDIANDDAHWADLAATALPDLQRLIV
                     ESESVPRHFTGIAGEHPPTDAPSPLVRGRAVLGMSADLYARRGVRTHLAGHGGDEVVGA
                     PVGYLHELVRRSPRTALDHLRGHRARHRWTLPQIVRGLSDRRSYAQWLRDEADLLTAPE
                     QASRLFGWGVPLRLPPWVTLHGTQSVAAMLRACADHAAPLASTRGNHWALHRIQAAGRL
                     YRLMLQEIQYPITHLPFLDDRVLEVCLAVRPADRGTPWRYKPLLAEAMRGIVPDPMLNR
                     TTKAGTDSDFYEGLRANRSEVIDLVETAPLAGQGLIDPIALRNAVLAPNHRWSPALEDT
                     LICLGWRPRIPITTTP"
     aSDomain        11788..11961
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_D5S18_RS07050_Lasso_Fused_RRE.1"
                     /evalue="1.80E-11"
                     /identifier="RREFam003.1"
                     /label="D5S18_RS07050"
                     /locus_tag="D5S18_RS07050"
                     /protein_end="58"
                     /protein_start="0"
                     /score="35.0"
                     /tool="antismash"
                     /translation="MSYRLNPRVCATDTDTGMVLLDKRSGRYFELNAAGRLVLRILLDG
                     RGPRQAAQALVAG"
     aSDomain        11788..12039
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_D5S18_RS07050_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.90E-25"
                     /identifier="RREFam002.1"
                     /label="D5S18_RS07050"
                     /locus_tag="D5S18_RS07050"
                     /protein_end="84"
                     /protein_start="0"
                     /score="78.7"
                     /tool="antismash"
                     /translation="MSYRLNPRVCATDTDTGMVLLDKRSGRYFELNAAGRLVLRILLDG
                     RGPRQAAQALVAGTSVPAADADRDVVAFLDTLRSRGLVI"
     gene            11788..12048
                     /locus_tag="D5S18_RS07050"
                     /old_locus_tag="D5S18_07055"
     CDS             11788..12048
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="D5S18_RS07050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07055"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_120039056.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.9e-24,
                     bitscore: 78.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.3e-10,
                     bitscore: 35.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.6e-14, bitscore: 47.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYRLNPRVCATDTDTGMVLLDKRSGRYFELNAAGRLVLRILLDG
                     RGPRQAAQALVAGTSVPAADADRDVVAFLDTLRSRGLVIQP"
     gene            12045..12452
                     /locus_tag="D5S18_RS07055"
                     /old_locus_tag="D5S18_07060"
     CDS             12045..12452
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="D5S18_RS07055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07060"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_203236637.1"
                     /sec_met_domain="PF13471 (E-value: 5.4e-29, bitscore: 94.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPMSVTAAPPLPWWQRPPILLAVTLAQLLAHRPPERIRATLSS
                     LRRGARPATYAQAQQARNQVLAASIHCAGEGCLQRSVATALLCRLRGHWPTWCVGVRTQ
                     PFGAHAWVEAEGRAVDEPHPDDYYRPIITVR"
     gene            complement(13144..14523)
                     /locus_tag="D5S18_RS07065"
                     /old_locus_tag="D5S18_07070"
     CDS             complement(13144..14523)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014983657.1"
                     /locus_tag="D5S18_RS07065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07070"
                     /product="serine hydrolase"
                     /protein_id="WP_203236638.1"
                     /transl_table=11
                     /translation="MATQWIQGLLPTTARALTHRLAVEQSHYRVPSLLAAVVRAGKPAW
                     WDARGRVDGSAPTTDTQYRIGSITKTMVGVLVLRLRDEGKLDLSDPLDRHVPGAAMGNR
                     TIAQLLSHTAGVRAESPGDWWERTEGGDWAELNTELEGAATVLPAGRRYHYSNVGYAAL
                     GELVARLRGRDWYDAVRAEVLAPLGMDRTTPAPVAPHATGWAVHPWADVTLPEPAHDHG
                     AMGAAGQLWSTADDLARWAIFLGGDTDPVLSKDTWEEMRQPATVVDDETWTDGHGLGVQ
                     LRRHNGRELIGHGGAMPGFIATVWADPADNTGVLFLSNTTYGGIRGQLDLGMLDLLAEH
                     EPVLPEEWLPATAFDPSLLALTGAWYWGTASIALHLRADGNLELKALAHGGRTSRFRPE
                     SADTWIGLDGYYAGERLRIVRTPNGSADHLELVSYIFTREPYPPTAPIPGGVDPAGWHT
                     R"
     gene            complement(14576..15445)
                     /gene="speE"
                     /locus_tag="D5S18_RS07070"
                     /old_locus_tag="D5S18_07075"
     CDS             complement(14576..15445)
                     /EC_number="2.5.1.16"
                     /codon_start=1
                     /gene="speE"
                     /inference="COORDINATES: protein motif:HMM:NF002010.0"
                     /locus_tag="D5S18_RS07070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07075"
                     /product="polyamine aminopropyltransferase"
                     /protein_id="WP_203236639.1"
                     /transl_table=11
                     /translation="MNEPPNFLERIDGELWLVEDERENMKISYRIKEVVFAESSDFQHV
                     MILDSHDFGRMLVLDGVVQTTSLDGHIYNEMITHVPLSIHPNPQRVLVVGGGDCGAARE
                     STRYHGVDAIDMVEIDELVVKVCKEYLPAVSENLDDPRVNFVYDDGIEFMKTKKNYYDV
                     IIVDSSDPVGPATRLFEYEFHRDIRAALKEDGLVVCQSQSPLFHRAVMRQTVDQLRDLF
                     PIVRPYLATVPTYPGGFWSFALGSKRYQALPAHPFDKPTKYLNDTILRACFALPEFLRP
                     DSEVGAAR"
     gene            15975..17072
                     /locus_tag="D5S18_RS07080"
                     /old_locus_tag="D5S18_07085"
     CDS             15975..17072
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019932179.1"
                     /locus_tag="D5S18_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07085"
                     /product="YeiH family protein"
                     /protein_id="WP_120038993.1"
                     /transl_table=11
                     /translation="MSIAVAQDKSRVGGVAAYIPGILLLIAVGALGKYAQIWWNALAKQ
                     QHWTVPDIEYVLWAILIGVVITNTVGLPPIFRPGVGTYEFWLKIGIVALGSRFVLGDVA
                     KLGGASFVQILVDMTVAGAIILTVARALGLSGKLGSLLAIGTSICGVSAIIAGKGAIRA
                     RDSEVGYAIAAILALGAVALFALPPLGHAIGLSDHEFGLWAGLAVDNTAETTATGYLFS
                     DSAGKTAVLVKSTRNALIGFVVLGFAAYWAARGEADAIAPGLRAKAGFVWAKFPKFVLG
                     FLAVSAIATFGWLTKQQTANLANVSKWAFLLTFAGVGLNTDLRELARTGWRPLVVAVIG
                     LVTVAVVSLGLVLFTSRVLHWGAPG"
     gene            complement(17035..17670)
                     /locus_tag="D5S18_RS34370"
     CDS             complement(17035..17670)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="D5S18_RS34370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158607815.1"
                     /transl_table=11
                     /translation="MTVTVVALTAISGALSHYLERRGQSVRRLGAHVPIALPPKSLERN
                     SYRSLGIDLCITEPDIGVRAARIAEQVRLRRIRAAHPLLDAQDRVVAVVPAPLRFREIA
                     RYRLDTVPESIAGHTVVSSVRRGGADLSFGGGAVVFTAGFPAIGSVMRLTHGVHGLGET
                     VTLSMHADAATIPDLDDYAELLRAAASEVVAALRNNASPVPPSAAPAR"
     gene            18898..20520
                     /locus_tag="D5S18_RS07090"
                     /old_locus_tag="D5S18_07095"
     CDS             18898..20520
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008715696.1"
                     /locus_tag="D5S18_RS07090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07095"
                     /product="cytochrome bc complex cytochrome b subunit"
                     /protein_id="WP_120038995.1"
                     /transl_table=11
                     /translation="MATRFGRIATVQANEFDERYRAAAFLKRSINKVFPTHWSFLLGEI
                     ALYSFIILLLSGVYLTLFFDPSMGEVIYNGAYQPLRGVSMSRAYESALNISFEVRGGLF
                     VRQIHHWAALLFAGSIIVHLFRVFFTGAFRKPREANWVIGTILLILAMFEGYFGYSLPD
                     DLLSGTGLRAAFSSITLGVPIIGTWVHWLIFGGDYPGTIIIPRLFIAHVLLIPGIMLAL
                     IAAHVALVWYQKHTQFPDPGRSERNVIGARIVPVFALDQGAYFAFTLGIVAIMSGLLQI
                     NPIWNMGPYNPSQISAGSQPDFYMMWTDGMMRLIPPWELYIGGHTVPGPVWGALTMGLI
                     FTLLITYPWIERRLTRDYARHNLLQRPRDVPVRTAIGAMVLAFYGVLTLTCVNDIIAYR
                     FNVSLNATTWVGRIGILLLPPLAYFIAYRFCIGLQRADRAVLDHGVETGLIRRLPDGEY
                     IELHQPLGPVDEHRHPIPLAYQGAPVPKKMNKLGLAGKPGTGAFFRADPEAESRRNLAQ
                     DHEEERKQLAVLRRAQENGRPEH"
     gene            complement(20626..20880)
                     /locus_tag="D5S18_RS07095"
                     /old_locus_tag="D5S18_07100"
     CDS             complement(20626..20880)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014981068.1"
                     /locus_tag="D5S18_RS07095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07100"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_239003594.1"
                     /transl_table=11
                     /translation="MSANLVLDAGKGASAVKIDSTGARWRKSSHSGPDGNCVEVAFLAD
                     GKVAVRDTKDNGFGPVLKVAPAAWDAFLNGFSSGEFNRA"
     gene            21280..21777
                     /locus_tag="D5S18_RS07100"
                     /old_locus_tag="D5S18_07105"
     CDS             21280..21777
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003931576.1"
                     /locus_tag="D5S18_RS07100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="D5S18_07105"
                     /product="DUF309 domain-containing protein"
                     /protein_id="WP_120038997.1"
                     /transl_table=11
                     /translation="MVERDRDDAGRARNARPRDRLGRPLPPGSPGVTRIPDDLELEPQQ
                     TLAFAQQLLTDGLAFNAHEVLEAAWKSGPFAERMLWQGLAQFAVGITHIQRGNPKGART
                     LLTRAVTRLSAYIPEGDVPYRIDRSGLIAHAESLIAALDSDKTIDATDLRPVLRLPDGA
                     EP"
ORIGIN
        1 gagaacgtgc atgatcgtcg tcgcccatcc cgcgactccg ctggattcgg cggcgtaaac
       61 ggctatctca ttgttcatgc ccgccacgtt aggtgctgaa ttctcgcaga tcagtaggga
      121 tttccggaca gtgaggtgtg gacttccaca cccctagcgc aggcagaaca ccgctgccgc
      181 ggcagcggcg aacaccgcga agttgtcccc ctgcgccgag gccaggacca tggtcatcac
      241 ccgctcatcc gggccaacga agacgtaggt gagataaccc aacaactcgc ccccatgtcc
      301 ccacagccgc accccgcagg gcagatcgaa acgctgcact cccaacccat agtggaagcc
      361 gagccccatc ggcactgtct gcttcattcc cgcgagcatc gaagcggaca gcagacgacc
      421 cgacatgagt gcatcgaaga atacggccaa atcacttgtg ctagagatca tctcgcctgc
      481 cgaccagtcc agtgcgggat tctgttcggt gacgtcgacg gtgacgcccg acgcgagctt
      541 gctccgtgct ggcagcagcg gggccggaat cgtcggatcg tcgccgggaa acagggtgtc
      601 gcgcaggccg agtggctcga ggatgcgggt gcggatcgca tcggcatacg gacggcccgt
      661 caccttctcg atcaccgacc cgagcaccac ataattggtg ttcgagtatc ggaacctggt
      721 gccgggcgcg aaatatgggg gatgagcgaa cgcgaccgac agcagtcgcg ccacgtcgaa
      781 atgccggaag cgatcttcgc cgcgccatcg attcgtcgac atgccgggct ctttcatgta
      841 gtcgtacaaa ccactggtgt ggttgagcaa ctgtcggatc gtgacggact ccccgcgggg
      901 gacgacaccg ggcaggatct gttcgatcgg atcgtccagg gcaaggagtt tctcgtcgat
      961 catctgcagg acgactgtcg cgacgaaggt cttcgtcaca cttccgatcc gaaaacgcgt
     1021 atcgggaagg acggtttcgc ccgcgtgcca gacccgcgtt ccccggccat ccgacacctg
     1081 caagaccgca gccgtcaccg gctcatccgc gcttcgatcc acgatgaatc cgatgacgct
     1141 gccccgaacc gtaaccagca gcagcgtcac cagcaccgca ggcgcgacca cgatcaccag
     1201 caaaaccgtc agcagacgtc gaatccatcg cattggccga agctatggcc gggccgtgcg
     1261 ccgaacaatg cggccgaccg cagacatccg ctactggaaa ccacagacat cgcggtatag
     1321 gaggcctgct cgggggtggt tgatcgccgg atgggcgatc gggattgacc ttgacggtaa
     1381 cgatcgttac cttcataaca gtaacgatcg ttaccatctt ggggggcggg cgcgcacgcc
     1441 cgatgagacc gccgccccga gcacgagaga ggagttcgca catggccgaa cgcggcgaga
     1501 gaacaatgga tacagcccga ggtcggtcat cggtacggca tgatccgaaa ggaattgacg
     1561 cgcaggcgga ttccccggat aagggctggc gcgcacggat cgcgatcctg gcgctgggtt
     1621 cgttcgcggt cggaaccgac ggctacgtca tcgtcgggct gctgccgcag atcgcgggaa
     1681 ccctgcacgt cggcatcgcc gcatccggtc aattggtgag cgtcttcgcc ctggtctacg
     1741 cgctcatggc acccgtgctg gccgcgctca ccggacggtg gtcgcggcgg cgggtgctcg
     1801 tcaccgcact cgcgctgctc ggtgcgggca atgcggtcac ggcgctggca ggcgactacg
     1861 cgctggtgct cgcctcgcgc gtggtggcgg gctgcggtgc ggcgctgttc tccgcgagcg
     1921 cggtggccac cgcatcgcat ctggcgccgc agcggcggcg gggcagcgcg atcgcgatgg
     1981 tgaccacggg cgccacgctg gcactggtgc tgggcgcccc gatgggcaca gtcatcggcg
     2041 acgcctgggg ctggcagtcg gcgatctggt tcatcaccgt cctcgccgcc gttgtcgcgg
     2101 ccgcgatcgc cgtgctgcta cccgatattc ggctcgatcc ggcggctacc ctgcggcagc
     2161 ggctcgcccc gctgaccgat atgcgcgtgc tgcgcgtgtt ggtcgtgacg ctgctgggct
     2221 tcgtcgccat cttcctgccc ttcacctata tgagcgcggt gttcgccccc gcgatcgacg
     2281 gccgagaatc ccggctcgcc ctgctgctca tggtgttcgg tatcgcggcc acggtgggga
     2341 atctgaccgc gggcaggctc gccgaccgct accgaccgcg gttcgtggtc gtcggcgcgc
     2401 tcgcgggcat cgcggtggtg ttcgcgatca tgccgctggt ccgggacagt ttcgtgctcg
     2461 cggtggcggt gcaggcgctg gccgggctgg tgtgtttctc ggtgatcggg ccgcagcagc
     2521 atcggatcat cgcccacgca ccggcaggcg gtgctccggt ggtcacctcg ctcaatctgt
     2581 cgacggcgta tctgggcaat ttctgcgccg gtgcgctcgg cgcggtcctg ctctcctcgg
     2641 gcgctgcgta cgtgcctgcg gtggcggcgg cctttgcgct ggtcgccggg ctggtcgccg
     2701 cgtggggccg ggatcggcga tgatggtggg catggtgctg cgcgaaccgg tcccggtggt
     2761 cgccgcccac gacggaggtg agtgaagcca tgccggtgcg ggccggatcg gcgctggatc
     2821 ccgacgcgac gcgggcgcgg gtgctggacg tggccgcccg actcttctac gagcgcagcc
     2881 tcgccgcggt gggtatgcgc gaggtcgcca ccgaatccaa cgcttcacag ctgacgatct
     2941 accgctactt cggctccaag gagggcctgg ccgccgccgt ggtccgcgaa cgcagcgacc
     3001 gcacccacgc ctggctggcc gagggcctgg ccgaggttcc cgcaggacgc gccagggtgc
     3061 tcgccctgtt cgacatgctg aaccgctggt tcaccgaagg tgactaccgc ggctgcccgg
     3121 tcctcaacta cgcggccgac tcccgcggcg gtacgaccga cctcgcggcc acccgccgcc
     3181 acctcgagcg ctaccggcag ctactggaac aactgctgac cgagacggga gtgccgaccc
     3241 cgcagacgct cgcccggcaa ctgctgctat tgatcgaggg cgccacggtc gtgagccagg
     3301 tcgacggccc cggcccggcg ggcgtcgatg cccgcgccgc agccgagacg ctgctcgacg
     3361 cggcaccgac ccgcgcttcg ggaacccccg cgccgcagga gaagtgacgc cccgaaaatc
     3421 gaccgagacc tgcggaacgg gctcggtttc cgccttcgga cggagctggc atctatccgc
     3481 atcggctatc cccctgggga ctctcgactg agcggaagaa cgaacctgta gcattctgca
     3541 caccatgtag caggatgggt agcctagagg tatgaaaacg attcagcagc gtgacctccg
     3601 caactacagc ggcaaggttc tcgccgaagt cgaagccggc gagagcttca cgatcactcg
     3661 caatggcaaa cctgtcgccg aactcaggcc cttgacccag cgcaccttcg ttcctgtcgc
     3721 cgaactcgcc cgcaccagcg cgaacctgcc acgcatcgac tacaacgaat ggcgtgccga
     3781 catggacgcg atgatcgacc aggaaaccca cggccgtgag taagcttgcc gcccctcggc
     3841 acgtgctgct tgacacatcg gtcctcatcg actacaccga cgtgcggtca acactgcccg
     3901 acgaagccga agccgctatc agtgcggtaa gtcttgccga actcgccgcc ggactgcact
     3961 ccaccagaga cccgataaat caagcccgac gtcaactccg gttccagtgg gtagcaaaat
     4021 ccttcaaccc gctcgccttc gatgctgaga ccgccaacgt ctacggatcg ctggctttcc
     4081 ttatcgacca gatcgggcgt aaacctcggg ggcggatcgc cgacctccag atagcggcaa
     4141 cagcagtcca acacagcctg ccgctataca cccgcaatcc ccatgacttc aaagggctcg
     4201 aaccgctact gaatgtcgtc gctgtgtagc agtgtggttg atggcgccac cgtcgtccac
     4261 cccgatattc gcatcgcacc gtcgacacac cttgcgacac aacgtttccg gcgagcatgc
     4321 cgcgtcgacc tccctggcct gaccggagca ttcatggcgc agtttgcaaa taacgctcat
     4381 cacgcaaccg gcgcgtgtca tacaatcaga ccgcttcgac cgcgagtacc cgccgttcga
     4441 aggaaatcga gatactttat gcaacaattc cagacggcat gggctcgcgc acatgttgct
     4501 ggtcgacgct atcgtcggcg ctcaatggtt tgacgctgcc tgcacgccgt atgtttcggt
     4561 cgtgccggtc gacagtgtca aatgccggaa attccgtgtc tccacagtga ggagtgcgaa
     4621 atggatgagt tgatacaacc gccagaactc ggcgaggtcg tcatcgagga gctcaccgca
     4681 gcggcgtccc attgcggtgg tggatgtggt gggtgcggtg gcccgtgcgg tgggtgtggt
     4741 ggcccgtgcg gcaacgcctg cggtggtggt tcctgtggtg gtggctgtca tggtggcggc
     4801 tgcggggcct gcggttagga gcccgttgtc ctgaccggca gttggactgt ccggctgtgg
     4861 aattcgttgg atactgctcg gccgggccat ccgtcggcta ccgaagcggc aggcgatgtt
     4921 gtcccggacc gaatcgattg gtacatgatt acgagagaga ccattgccgg gcagtcccac
     4981 cccttcgttg ctgttcacga tcaatcgctc caatagcaat tgcggtgcgc ggcccctccg
     5041 atcgactgga tcatgtgggt cgccttttat tgccctatcg gcacaggttg cgccgatgcg
     5101 gtcggttcga cagtacaagt gaggccgtct cgaggaggac gtgtggattc agtcgttcga
     5161 ttcaaacgcc atttacgagc cgagtctgtg ccgggtgatg ccgtctatct cttttccgag
     5221 agtgcacgac agatcagact cgacggtgcg ttgatcgagc ggctcatgcc attgttggac
     5281 gggggccgga gccggtccga catcgtagcc gcgctggcgg gcgagttcgg tggcgaccgc
     5341 gtcggttcga cgttgactcg gctcgccgaa gcgggattgg ttgtcgagtg cgacccgggg
     5401 gtggattcac gggcaggcgg ttattgggaa ctgtgcggcc tggaaggaga cgccgcggtc
     5461 gccggtttgg cgagtcgggt agtcgatgtg aggtgtgtcg gtgacgtgga tggggcaggg
     5521 ttcgatgctg ccgccgcagc gctcggtatg cgggtcgatg cgggggatcc cgatctgcgg
     5581 gtagttctca ccgacgatta tctgcgcggg gatctggccg agatcaaccg cggcaggctc
     5641 gacgatggcg gcgcgtggat gctggtgaaa ccggtaggga gcgtggtgtg gatcgggccg
     5701 gtattcgagc cgggtcgcac cgggtgctgg cagtgcatgt cgacgtatct cgagacccat
     5761 cagattttgc gaaggtacct gcggcaacgg tccggcgcag gcgaaccgcc tgtcgtatcc
     5821 gtggcggatc tgcccgcgac ccgccggatg gctgcggaga tggccgcgct gcacgccgcg
     5881 aagtggctcg ccgggttcaa ccccggcgag ccgggtgccg gcgaatcggt tccggcgggt
     5941 cccgagatct tcaccctcaa taccgcgcgg tggcacgggc agcggcatgt actgcacaag
     6001 cgtccgcagt gcccggcgtg cggtgatccg gaaatccagc agcgtctgca gcgtgctccg
     6061 gtgcggctgg gcagcaggct caaggtggtc acgtccgatg gcgggcatcg cgcatcgact
     6121 ccggagacgc tgctatccga ctacgagtcg atgatcagcc cgatcaccgg tccggtgccg
     6181 cacctgacgc ctacttcccc cgccgagggc ctgcacacct atctcgcggg agccaatatg
     6241 gccgtcgcga tggccgatgt cggcgctctg cgggcgggcc tgcgccaatc cgcgggcggc
     6301 aagggaatga ccgacgtgca ggccaaggcc tccgcgctgg ccgaggcgat cgagcgctac
     6361 agcggtgtgt accggggcga cgaggccacg atctccgcga ccatgtcgga gttgggcgac
     6421 gcggcgatcc atccgaacgc cttgcaactc ttcagtgacc ggcagttcgc cgaccgtgcc
     6481 gcctggaatg cgaaacagtt gcgcaaccag catgtctgcg atccgttcga ccccgcgcga
     6541 cgcaccgagt ggaccccggt gtggtcgctg agccgcgata ccacccggca cctgcccacc
     6601 gcggccctgt tctacggtta cccgctaccg tgcggcggct ggttcgccgc cgccgattcg
     6661 aatggcaatg cggcgggtag ctgtgtggaa gatgctgtgt tacaagggtt cttggagctg
     6721 gtcgagcgcg acagcgtggc cgtgtggtgg tacaacatgg tgcgcaggcc gggaatcgac
     6781 ctggcgagct tcgacgaacc gtacttccag cgctggcagc agcggtaccg gtccatcggc
     6841 cgggagacct gggcgctcga cgtcaccacc gatctgggaa tccccaccgt ggtcgcggtg
     6901 tcccgccgcg tcgaccagcc acaggaggac ctcgtcttcg cgttcggcgc acacttcgac
     6961 gtcaagatcg cgatctcgcg cgccctcacc gagatgaatc aattcctgaa tctgtacacg
     7021 gccgcgaccg gagagctcca gcattggttg cgcagcgcca cggtcggcaa tcagccctac
     7081 ctgctgtccg ccgaagacca accgctgcgc gttgccgccg attaccgcga ccccaccacc
     7141 gacgacctcg ccgaggacat cgcgctggca cagcgcatcg tcgagaacgc gggaatggaa
     7201 ctgctcgtcc tcgatcagac ccggcccgat atcgggcttc cggtggtcaa agtaatcgtt
     7261 cccggcatgc ggcacttctg gacccgctac gcaccgggca ggctctacga tgttccggtt
     7321 cggttgggat ggttgtccga gccgacgccg gagaccgaat tgaaccccat cgggatgttc
     7381 ctgtgaacca atatcattgc cgtgtagcaa tattcgtcca cgacctccgc atttctcgag
     7441 acatcgacga gccgcccgct catcccacct aggttcggtc ctcgctgagc tgttgggccg
     7501 aaccgccgcg ctcggccatc gactgacgat gcgcgtcaat cggatcggcg gatcgcggac
     7561 gggatccggc gctgacggcg agcagtacca gggcgatcag ttcgaagccc gcgcctgcga
     7621 agggaagggc ggcgagcgct cccagatcgg tgagtagacc gccgacgacg gccgcgattg
     7681 tctggccgag atatacggcg ctgttgttga gtgccaacaa catatccgcg tgtttgccgc
     7741 cgatgccgat caggcggtgc tgaatcagcg ggaagctcac ccagtgcacc aggccccaca
     7801 ccgcgacacc gatcgcggcg ccgggcgtcg accggaacgc gatgccgagc gcggccagga
     7861 cgaggatcag cagaccgatc gagcaggcga gtcccgcagt gggattcacc cgatcggcca
     7921 gtcggccgcc accgaggacg ccggcgaaac tgccgatccc gaacagcaac agcagccagg
     7981 gacggtcgcc tagggcgaca tgggtgacgc tgtcgaatat cgaaccgagg taggtgtagg
     8041 tcacgaaggt gccgaccacc cagagcatcg tgatcgtcaa cgccgtcggc gcgcggcgaa
     8101 tccgtatggc ggacactcgt tctcgcagac cgatgcctgt tgttccggga agtgcgggaa
     8161 ggctgacgac caagccgata ccggtggcga cggccagtgc ggcgacgaat ccgaaggccc
     8221 accgccacga cagtgcgttg ccgatcgcgt cgccgatcgg aacacccagc gctatcgcgg
     8281 aagtcatgcc cgcgtacacg atcgccagtg cccggccgcg ccgctcgggt gcggtgatgc
     8341 gcgctgccgt gcccgaggcg gtcacggcgt acagcgccgc accgagaccc gcgacgaacc
     8401 ggctgaccag cagtatcgaa tagtcggggg ccaccgctga aagcacgttg cccgccgcga
     8461 ataccgccag caccgcgccc agcagtagcc gccggtccag acgggccgtg aggccggtga
     8521 ggatcggtga tgcgacggca taggtgatcg cgaagacggt caccgtctgg cctgccgccg
     8581 acatggacag ccccagatcg tgcccgagcg cgggcagcag cccggacacg atgaacagat
     8641 cggtgccgat cgcgaacatg cccagggcga gcagccaggt tcggatggtg gccgagcgcg
     8701 cctcggcggt cgtgtgctgc gacatctgca ctctcctcaa actaaccagt catatggtta
     8761 ctcggtcggt aacctatcat ctggttatgg acgcggaaga ggtgcgggac tgggtctggt
     8821 acggcggtcg ggtgtcggtc gacttcgtca acacccggcg cgatcgctat gcgggcggcc
     8881 gggagctgct ggaacacccg tcggacctcg acgcgtggtt cacaactgcc caattgatcc
     8941 cgtgccgagc cgaagtagcc gaggaactac tgcgcgaggc acgacagctt cgcgaggcca
     9001 tcgacgccgg aatacgttcc gtcgtcggct cggaaccgtt cgacgccgga gctcgcgacg
     9061 tgatcaacaa ctggcttgct cgagcgaacc atccaccacg actggaattg tccgatggac
     9121 taccgatact gcggatggac gacgcaccca ccgacgcgac cggcgcgctg taccgaatcg
     9181 cactcgacgc cgcccaactc ctcggcagcg acacccgctc ccgaatccgc atttgcgccg
     9241 gagccgaatg cagcggccga ttcgtcgacc tctcggtagc gggccgccgc cgctggtgcc
     9301 gaatgtcggt ctgcggcaac cgggccaagg ccgcacagca ccgcaggtcg gcccgttccc
     9361 aacattgatc gccgcatcgt cgcgaggcag gaagaacagc caatccgcga cgagtgccgc
     9421 gagaacaaag acgacaaacg cagccgcggt cgaaagtcat ttcctggcac ggagttcggt
     9481 cgccggagtt ctacatcatg cgacttcgtg aacagtttgt ggctgctcgc aggccggccg
     9541 ggtcgacttc cacaagaaac cctcttcaaa gtcgcggcag accaacccac acagaggcac
     9601 aagcccccac ctcggcggtc ggcctcaaat cgcgaactcc accgaagtcc cgttgtgaac
     9661 agcgaaatat gctgcgccac aatatcctcc atttgcgaca gtagccgccc cgggcgcttc
     9721 cggtgatttg aaaaatacgt atccaacctg atcggaacac atgctagggt tgcccacgta
     9781 cacgcggggc acagtttgtt tcatcggcga aaaattccac tacctgtatg gaagaggaag
     9841 agtcatggag cagaacaagg tacgcacgag cgaccgtcgc gccgagaatg tggaatcgta
     9901 cgagccgcca ctgctggtcg atgcgggcga attcaccgag cggactcgtg gcggtacgga
     9961 caagtaccga gaagcctcca tcggacgctt cctttaactc gtgtcgtggt tcgcggcact
    10021 tccggataat gcggcgggtc gagatatggt ggcccgcttt cccgacagtg cgcggcggat
    10081 cgccgcgcac ggttccggcc tgccctggtt gatcggctcg ctgcccccgg aacagtgcac
    10141 gatcgtcgaa tccggatccg cgcggctggc agtgctcgga tactgcccga gcaccgctgt
    10201 cgcgctcgcc gagcagttgg tccggatccg agggttggcc gatctggatg cgctcgcggg
    10261 tgcgctgcgg ggcagttgtc atctggtgct gtcgctggat gggaatacca gggtgcaggg
    10321 cacggtatcg ggtttgcggc gggtgttcta cgcgcggtgc gcgggccgtg tcgtcgcggc
    10381 cgatcgcgcg gacgtactgg ccggggcgac ctcggcggaa cccgacgaac tgtggctcac
    10441 cgccgcggtc ctcggaccgg atcttccgca tccgctcgcc gaccggaccg catggcgcgg
    10501 gatcgaagcg gtgcccgccg attccgcgct gcacctggac gcccgcgggc aggcgcgact
    10561 gcggcgctgg tggacgccgc cggagccgac gctgtcctcg gccgacggcg cgcaggcact
    10621 gcgcacggaa ctgcgggatg cggtggcggc ccgaacgcgg cgcgcatccg ccccggtggg
    10681 atgcgatctg tccggcggta tggactcgac cgcgctgtgt ttcctcgcct cgcgcggcga
    10741 tccggtggcc gtcaccgtgc actaccgcga tatcgccaac gacgatgccc actgggccga
    10801 tctggccgcc accgcgctgc ccgacctaca gcgtctgata gtcgaatccg aatctgtacc
    10861 aagacatttc accggtatcg ccggggagca tccgcccacc gacgccccat caccgctggt
    10921 gcggggtcgg gctgtcctcg gtatgagcgc cgacctgtac gcccggcgcg gcgtgcgaac
    10981 gcatctggcc gggcacggtg gtgacgaggt cgtcggggcg ccggtcggat acctgcacga
    11041 actcgttcgc cgcagtccac gcaccgcgct cgaccacctg cgcggccatc gggcgcggca
    11101 ccgttggacg ctgccgcaga tcgtgcgcgg actgtcggac cgacgctcct acgcccaatg
    11161 gctgcgcgac gaggccgacc ttttgaccgc gccggagcag gcgagtcggc tgttcggttg
    11221 gggtgtccca ctgcgcctgc cgccttgggt caccctgcac ggaacacaat cggtggccgc
    11281 gatgctgcgt gcctgcgccg accacgccgc acccctggca tcgactcgcg gcaaccactg
    11341 ggcactgcac cgaatccagg ccgccgggcg gctgtaccgg ttgatgctcc aggagatcca
    11401 atacccgatc acacatctgc catttctgga cgaccgcgtt ctcgaggtct gcctcgcggt
    11461 gcgaccggcc gaccggggaa caccgtggcg ctacaaaccg ctgctggccg aggcgatgcg
    11521 cggcatcgtg cccgatccga tgctgaaccg caccacgaaa gccggcacgg acagcgactt
    11581 ctacgagggt ctgcgcgcga atcgaagcga agtgatcgac ctcgtcgaga ccgcaccact
    11641 ggccgggcag ggactcatcg atcccattgc cctgcgcaac gccgtcctcg cccccaatca
    11701 ccgctggtcc ccggcattgg aggacaccct catctgcctc ggttggcgac cacgaatccc
    11761 gatcaccaca acaccgtgag gagcaccgtg tcctaccgac tgaacccccg cgtatgcgcg
    11821 accgacaccg acaccggaat ggtgttgctg gacaaacgtt ccggtcgcta tttcgaactc
    11881 aatgcggcag gcaggctggt gctgcggatc ctgctcgacg gtcgaggccc acgacaggcc
    11941 gcgcaagctc tggtcgcggg gacgtcggtg cccgcggcgg atgccgaccg cgacgtcgtc
    12001 gccttcctgg acaccctgcg ctcgcgcggg ctggtgatcc agccgtgagc gtgccgatgt
    12061 ccgtcaccgc cgcaccccca ctgccctggt ggcagcgacc acccatcctc ctcgcggtca
    12121 ctctcgccca actgctcgcc caccggcccc cggaacgaat ccgcgctacc ctgtcatccc
    12181 tgcggcgcgg ggcgcgcccc gccacctacg cccaagccca gcaggcccgc aatcaggtgc
    12241 tcgccgccag catccactgc gccggagaag gctgcctgca acgctcggtg gccaccgcac
    12301 tgctctgccg cttgcgcggc cactggccca cctggtgcgt cggcgtccgc acccaaccct
    12361 tcggcgccca cgcctgggtt gaagcggaag gccgcgccgt cgatgaaccc caccccgacg
    12421 actactatcg gccgataatc accgtgcggt gatcaggtcg aaatcgcctg catagcaaca
    12481 ctaatcgccg atccgggaag gtagcctcgg ccaaccatga tggctggatg gcgagatcac
    12541 caagccgggc gccatcggcg gaccggcgtg taggcagggc aggtcgacta ccaggccggc
    12601 cgttgatcgc gctcagcttc cggagtctgc tggatccggt cacggcccga gccgtcggtc
    12661 cgtaccagta cgccggggtc gggagggaat tcttcggtca gtggagccgg catgtggtac
    12721 cgccgcgtat gtggaagcgc gacttcgaca agcttcccgt cctcgaacat ccacaggccg
    12781 aagcaatcgt cctcctcgtc gtgaatcaac acctggacgc tgtccgggcg gggccatgag
    12841 agagactcga gatgcgcgaa aagccctgtt cgagtccgca tccggtcgaa ttcggtggcc
    12901 catccgatgc cgaaggaacc aggccactgg ctctcgatcg gtacgaaccg gcctcgtcaa
    12961 ctccggtttt catcgtcgcg ggtcagcggc tgcatgacct cgtccgcgtg caacgccaac
    13021 acgatcacct ctgcgattct gctcatgacc gcgaatcaga gcacgtgccg atttgccgat
    13081 caaccgaatt cataagcggc aaccagacgg gccgcaggat gcggattcgc ttgtgggaaa
    13141 gggtcagcgg gtgtgccagc ctgctgggtc tacgccaccg gggatggggg cggtgggtgg
    13201 gtagggttcg cgggtgaaga tgtagctgac gagttcgagg tggtcggcgg agccgttcgg
    13261 ggtgcggacg atgcgcaggc gttcgcctgc gtagtagccg tcgagtccga tccaggtgtc
    13321 ggccgattcg gggcggaagc gggaggtgcg gccgccgtgg gcgagggctt tcagttcgag
    13381 gttgccgtcg gcgcgcaggt gcagggcgat ggaggcggtg ccccagtacc aggcgccggt
    13441 gagggcgagc agggacgggt cgaatgcggt ggcgggcaac cattcctcgg ggaggacggg
    13501 ttcgtgttcg gcgaggaggt cgagcatgcc gagatcgagt tggcctcgga taccgccgta
    13561 ggtggtgttg gacaggaaca gcacgccggt gttgtcggcc gggtcggccc agacggtggc
    13621 gatgaatccg ggcatggcgc cgccgtggcc gatcagctcg cggccgttgt ggcggcgcag
    13681 ttgaacgccg agaccgtggc cgtcggtcca ggtctcgtcg tcgacgacgg tggcgggttg
    13741 acgcatctcc tcccaggtgt ccttggacag caccgggtcg gtgtcgccgc cgaggaagat
    13801 cgcccagcgc gccaaatcgt ccgcggtgga ccagagttga ccggccgcac ccatcgcgcc
    13861 gtgatcgtgc gcaggctcgg gcagggtgac atccgcccac gggtgcaccg cccatccggt
    13921 ggcgtgcggg gcgacggggg cgggggtggt gcggtccatg ccgagcgggg cgagcacctc
    13981 ggctcgcacc gcgtcgtacc agtcgcgtcc gcgcagcctg gcgaccagtt cgccgagcgc
    14041 cgcgtagccg acattgctgt agtggtatcg gcggcccgcg ggcagaaccg tggccgcgcc
    14101 ttcgagttcg gtgttcaact cggcccaatc accgccctcg gtgcgctccc accagtcgcc
    14161 gggtgattcg gcgcgcaccc ctgcggtatg cgaaagcagt tgcgcgatgg tgcgattccc
    14221 catcgccgca ccgggcacgt gccggtcgag cgggtcggac agatccagct tgccctcgtc
    14281 gcgcaaccgc agcacgagca cgcccaccat ggttttggtg atcgatccga tgcgatattg
    14341 ggtgtcggtg gtcggcgccg acccgtcgac gcggccgcgc gcatcccacc aggcgggttt
    14401 accggcacgg accacggcgg cgagcagtga aggcacccga tagtgcgact gttccaccgc
    14461 gagtcgatgg gtcaatgccc gcgctgtcgt cggcagcagc ccctggatcc actgtgtcgc
    14521 catcacgcga gcctggcacg cggcggcggc gatgtccatc gattcgcggg aaggatcagc
    14581 gggccgcgcc gacttcactg tccgggcgga ggaattcggg gagggcgaag caggcgcgaa
    14641 ggatggtgtc gttgagatat ttcgtcggct tgtcgaatgg gtgcgcgggg agggcctggt
    14701 accgcttgga gcccagcgcg aagctccaga agccacccgg ataggtgggg acggtggcga
    14761 ggtatgggcg gacgatcggg aacagatcgc gcaattgatc gacggtttgc cgcattaccg
    14821 cacgatgaaa cagcggtgat tgactttgac ataccacgag gccgtcttct ttcaatgctg
    14881 cccgaatatc ccgatggaat tcgtactcga acagtcgggt ggcaggtccg acgggatcgg
    14941 aggagtcgac gataatgacg tcgtagtaat tcttcttggt cttcatgaac tcgatgccat
    15001 cgtcgtagac gaaattgaca cgtgggtcgt ccagattctc cgagacggcg ggcagatact
    15061 ccttgcagac cttgaccacc aactcgtcga tctccaccat gtcgatcgca tcgaccccgt
    15121 gatatctggt cgactcgcgg gccgccccgc agtcaccccc gccgaccacc aggacacgct
    15181 gcggattcgg atggatcgac agcggtacgt gggtgatcat ctcgttgtag atgtgaccgt
    15241 ccagggaggt ggtctgcacg acgccgtcga gcaccagcat ccgtccgaaa tcgtgggaat
    15301 ccaggatcat cacgtgctgg aaatccgagg attcggcgaa gacgacttcc ttgatgcgat
    15361 aggagatctt catattctcc cgctcgtcct ccacgagcca cagttcgcca tcgatgcgtt
    15421 ctaggaaatt tgggggttcg ttcacgatga gttccacgct ccttcggtga tccgacacca
    15481 tcgatagtat tcggggaccg gaatgggcaa tggcgctcgg cgtggcgcga acggtggttg
    15541 cccacagttg accgaggatt gcgccacacg cgcccgaatc ggtgatcttc gcgaaaggcg
    15601 agcggggcga gcaggcagag gccgaggcac acatacccgc gcgccaccgg gtcgaaatga
    15661 ttgcggcaca ccgattgacc tgtcaggttg tacggcgagt caatggccgc cgcccgctcg
    15721 tagggggtcc accgcggcac cgcctccggc cccgtcgctc gggaaggaat ctgtccgatt
    15781 cgaatactgg tcggcgacca ccgaaaagcc gcatagtccg tgccggaact gccggaacta
    15841 tctggaggac gcggtgagtg aggtgcaacc cgagtcgacg cggatcggcg cggactggtg
    15901 gagtgtgatc atcggcggcg tcgtgaccct gctggcgata ttcgacgcgc tgccgcggat
    15961 tccgtggtga cgcgatgagt atcgctgtag cacaggacaa gtcgcgagtc ggcggggtcg
    16021 ccgcctatat tcccggaata ctgctgctga tcgcggtcgg cgcactcggc aagtacgccc
    16081 agatctggtg gaacgcgctg gcgaaacagc agcactggac cgtgcccgat atcgaatacg
    16141 tgctgtgggc catcctgatc ggcgtggtca tcaccaatac cgttgggctg cctccgatct
    16201 tccgccccgg cgtcggcacc tacgagttct ggctcaagat cggcattgtc gcgctgggct
    16261 cgcgcttcgt cctcggcgat gtggcgaaac tgggcggcgc gagcttcgtg cagatcctgg
    16321 tggatatgac ggtggcgggc gcgatcatcc tgacggtggc gcgggcgctg ggactttcgg
    16381 gcaaactcgg atcgctgctg gccatcggca cctcgatctg cggcgtctcg gccattatcg
    16441 cgggcaaggg cgcgatcagg gcccgcgact ccgaggtcgg ctacgccatc gccgcgattc
    16501 tcgcgctcgg cgcggtcgcg ctgttcgcat tgccgccgct cggacacgcg atcgggttga
    16561 gcgatcacga attcgggctc tgggccggac tcgcggtgga caatacggcc gagaccaccg
    16621 ccaccggata cctgttctcc gattccgccg gtaagacagc ggttctggtg aagtcgaccc
    16681 gcaacgcgct gatcggcttc gtggtcctcg gcttcgccgc ctactgggcc gcacgcggcg
    16741 aagccgatgc catcgccccc ggactgcggg ccaaggcagg cttcgtgtgg gcgaaattcc
    16801 ccaagttcgt gctgggcttc ctcgccgtgt cggccatcgc gaccttcggg tggctgacca
    16861 aacagcagac ggccaatctc gccaatgtct ccaagtgggc cttcctgctc accttcgccg
    16921 gggtcggact caataccgat ctgcgggagt tggcgcgcac cgggtggcga ccgctggtgg
    16981 tggcggtgat cgggctggtg accgtggcgg tggtatcgct cggattggtg ctgttcacct
    17041 cgcgggtgct gcactggggg gcaccgggct agcgttgttc cgcagtgccg caacaacttc
    17101 cgatgcggcg gcgcgcagca gttcggcata gtcgtcgaga tccgggatcg tcgcggcatc
    17161 ggcgtgcatc gaaagggtca ccgtctcccc cagcccgtgc actccgtgcg tcaaccgcat
    17221 gaccgagccg atggccggaa atcccgcagt gaacaccacc gcgcccccgc cgaaggacaa
    17281 atccgcaccg cctcgccgga cgctggagac aaccgtatgt cccgcgatac tctccggcac
    17341 cgtatcgagc cgatagcgcg cgatctcgcg aaagcgcagc ggcgccggga ccacggccac
    17401 gacccgatcc tgcgcgtcga gcagcggatg cgccgcccga atgcgccgca gccgcacctg
    17461 ttccgcgatc cgcgccgcac gcacaccgat atccggctcc gttatgcaca gatcgatacc
    17521 gaggcttcga tagctgttgc gctccaatga cttcggcgga agcgctatcg gcacatgtgc
    17581 ccccagtcgc cgcaccgact gcccgcgccg ttcgagatag tgcgacagag cgccggaaat
    17641 cgccgtcaat gccacgacag tcaccgtcat atcgggtacc cgcaactccg atgcacggaa
    17701 cacgatcatc cgcaccagat gtctcgtatc tccaggtgcg gaaccacctt cggtcgatgc
    17761 cgcggcgatc gaaccgcccg ccggcgcaga ttcggaacac tccgccggcg agcccgattc
    17821 cgactccacg cctgtctcgg caatcgaatg cccggcctcg agtgagtctc gcacagcggg
    17881 acggtcccgc tccccaaccg atgtggccgg tgcgtctccg cgggccgaac gccccggtcg
    17941 attcaacacg cacgggggat actccggccc cgccgcagga attccaccgg atgccgtgag
    18001 ctcggccaac tttcgccggg cgcgatacgc ggacacgccg cgcacaagtg tctgcccgat
    18061 ccgaatcggc atcgcgaata cggccagggc tgcggctacg agatcgcgcg cacgatcggt
    18121 ggacggaaac cggtaggcat cccggacacc ttttctcggc ggatgcgacc agaaccgatg
    18181 agttccggtg cggcagtggg gatcgggtgc gatcagtagc cggccccgac cgcgcgggcg
    18241 ggtcggaagc cgacctcccc ccatcatcgc agcggattgc accgagtccg tcccgaacaa
    18301 cgcccgcgcg atccgcgccg cccgccgccc atcggccaac gcgtgcgata tctgcaatac
    18361 cactatcaga gcgggatccg acccgcactc cggaaccccc agcacacccc gaaagacgtg
    18421 taatctccac gcgcacaccg ccgcatccac ccccgtcccg accaactccc cgagatcggc
    18481 gcagagagtc acccaatccc actgcggccg ttcatattcc acaaactgat ccgacgttgt
    18541 cccgccgcgc acccaacgtg gatatccgag ttcacccggc accggccgca accgtagacc
    18601 cagatccgga atcgaggcgg agcgcctggc gatggtcgcg cgcaattccg caccggacgc
    18661 accggcatcc cggaagcagt acagcaggaa ttgatcgttg cggatgcgtc gggacaacca
    18721 gtacatggtc gtgtccgagg ccgtcgcggt caccatgccc agaccctagt gggcactgtc
    18781 gacgaggcct atccggcgct acgaccgatg tttcggtcaa acccatcgat tccgcgacac
    18841 taccctgcta ccgtctgtag tagaggaata tcgcagtctc ggggacgggg tgctgccatg
    18901 gcaactcggt tcggtcgcat cgcgacggtg caggccaatg aattcgacga gcggtatcgc
    18961 gccgccgcct tcctcaaacg gtcgatcaat aaggtcttcc cgacgcactg gtcattcctg
    19021 ctcggcgaga tcgccctgta cagcttcatc atcctgctgc tctcgggtgt ctacctgacg
    19081 ctgttcttcg acccgtcgat gggcgaggtg atctacaacg gcgcgtacca accgctgcgc
    19141 ggggtgagca tgtcgcgcgc ctacgaatcc gcgctgaaca tctccttcga ggtgcgcggc
    19201 ggcctgttcg tccgacagat acatcattgg gccgcactgc ttttcgcggg ttcgatcatc
    19261 gtgcacctgt tccgggtctt cttcaccggc gcgttccgca aaccccgcga ggccaactgg
    19321 gtgatcggca cgatcctgct catactggcc atgttcgagg gatatttcgg ctactcgcta
    19381 cccgacgacc tgctctccgg caccgggttg cgcgccgcgt tctcctccat cacgctgggc
    19441 gtgccgatca tcggcacctg ggtgcactgg ttgatcttcg gtggcgacta tccgggcacc
    19501 atcatcattc cgcggctgtt catcgcgcac gtcctgctga ttcccggcat catgctggcg
    19561 ctgatcgcgg cgcatgtggc gctggtctgg tatcaaaagc acacccagtt ccccgatccg
    19621 ggccgcagcg agcggaatgt gatcggcgcg cgcatcgtgc cggtgttcgc actggatcag
    19681 ggggcgtact tcgcgttcac gctcggcatc gtcgcgataa tgagcgggct gctgcagatc
    19741 aatccgatct ggaatatggg accgtacaac ccttcgcaga tctccgcggg ctcccagccg
    19801 gatttctaca tgatgtggac cgacggcatg atgcgcctga tcccgccctg ggagctgtat
    19861 atcggcgggc ataccgtgcc cggcccggtc tggggcgcgc tgaccatggg cctgatcttc
    19921 acgctcctga tcacctaccc ctggatcgaa cgcagactga ccagggacta cgcccggcac
    19981 aacctcctgc aacgcccgcg cgacgtaccg gtccgcaccg ccatcggcgc gatggtgctc
    20041 gccttctacg gggtgctgac gctgacctgc gtcaacgaca tcatcgccta ccggttcaat
    20101 gtgtcgctga atgccacgac ctgggtgggg cggatcggca ttctgctgct cccgccgctg
    20161 gcctacttca tcgcctaccg gttctgcatc ggattgcagc gcgccgatcg cgcggtactc
    20221 gaccacggtg tggaaaccgg cctgattcgc cgactgcccg atggcgagta catcgagctg
    20281 catcagccgc tggggccggt ggacgaacac cgacatccga tcccgctggc ctatcagggc
    20341 gctccggtgc cgaagaagat gaacaagctc ggcctggccg gtaagccggg caccggcgcc
    20401 ttcttccgcg ccgatccgga ggccgagtcc cggcgcaatc tggcgcagga ccacgaggag
    20461 gaacgcaagc agttggccgt gctgcgccga gcccaagaga acggccgacc cgagcactga
    20521 gccgacaccg ccaaccgcgc cgacgcaccc gccgaggcaa agcgaaggcc ccgagtccac
    20581 agcgacccgg ggcccgcaat tgcccattcg ggcactaccc atacatcagg cgcgattgaa
    20641 ctcccctgac gagaatccgt ttaggaacgc gtcccacgcg gcaggcgcga ctttcagcac
    20701 cgggccgaat ccgttgtcct tggtatcgcg aaccgctact ttaccgtcgg cgagaaatgc
    20761 cacttccacg cagttcccat ccgggccgga gtggctgctc ttgcgccacc gggcaccggt
    20821 cgaatcaatt ttcacggcac tagctccttt gcctgcgtcg agaacgagat ttgctgacat
    20881 tgttcgaact cgcaccgaca tccggcggga acaccgaatg ccgcgtgcgc ctgaaggtag
    20941 cgcgcggcat tgccgatgcg ttgtgatcgc tctgcacttc gagatcgccc tgcatttcga
    21001 gcacttcgag aggtacaacc cctgcggggg gctaacccca cgcagcagac tagcagcttc
    21061 gacgaaagtt tgcccgactc ttgtctattc aaccatcgaa actgccaacg ttgcgaagac
    21121 aaaatgttgc ggagacattg ccggcaaccc aaagccattc cagatggcgg taattagcca
    21181 tgatatctac cggtgtgatt gatccgtgat ccgtcacggt gccggtaggt tgccccggat
    21241 gccgagcagc gaccgtcgcg gcgatggaag atggcagcca tggtggaacg tgatcgcgat
    21301 gacgcaggcc gcgcccgaaa tgcccgccca cgagacagat tgggccgtcc gctgccgccc
    21361 ggcagccccg gcgtcacgcg catacctgac gatctggaac tggagccgca gcaaaccctt
    21421 gccttcgctc agcaactact gacggatggg ttggcattca acgcgcacga ggtattggag
    21481 gcggcatgga agagcggccc gttcgccgaa aggatgctgt ggcagggact cgcccagttc
    21541 gcggtgggta tcacgcacat acagcgcggc aatcccaagg gtgcgcggac actactgaca
    21601 cgtgcggtca cccgcttgtc cgcatatatc cccgagggtg atgttccata ccgaatcgat
    21661 cgctcgggat tgatcgcaca cgccgaatct ctgatcgccg cactggattc ggacaaaacg
    21721 atcgatgcga cggatttgag gcccgtgctc cggcttccgg acggggccga accgtagcac
    21781 cgaaccgcgc atacgatggc ctgcgtgcgg atcatcatca ctcccccgga acgaccccgt
    21841 gtctgagcgc ggcgcgggcc ggttcgcgcc gagcccatcc ggggatctgc acctcggcaa
    21901 cctgcgcacc gccatgctcg cctgggccta cgcccgcagc accgggcggc gcttcctgct
    21961 gcgggtagag gatctggacc gggtccggcc cggcgccgcc gaacgtcaac tcgccgatct
    22021 ggccgacctc ggactggact gggacggccc ggtggtccgt caatccgagc gcatcccgcg
    22081 ctacgacgcg gccatcgccg aactcaccgc cgcgggccgc acctacgagt gctactgcac
    22141 gagaagagaa atccagcagg ccgcgaccgc tccgcacgga ccgctcggcc actaccccgg
    22201 cacctgccgc gagctgaccg agaccgaacg cgccgcccgc cgcgccgaag gccgaccggc
    22261 cgcgctgcgc ctgcgcgtca ccgccgacga agtcggccga tccaacaccg ccgatgaatt
    22321 cggccgatcc ggcaccgccg accatgtcgg ccgatccaac accgccgacg aattcggcta
    22381 cttcaccatc atcgacgacc tgcacggccc ctaccggggt ccggtcgacg acgtggtgct
    22441 gcgccgcggc ga
//
