LOCUS       NZ_KZ984531            24231 bp    DNA     linear   CON 31-MAR-2024
DEFINITION  Staphylococcus argenteus strain PR02 PR02_scaffold_1, whole genome
            shotgun sequence.
ACCESSION   NZ_KZ984531
VERSION     NZ_KZ984531.1
KEYWORDS    WGS; RefSeq.
SOURCE      Staphylococcus argenteus
  ORGANISM  Staphylococcus argenteus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 2648450)
  AUTHORS   Lee,L.S., Teh,L.K., Zainuddin,Z.F. and Salleh,M.Z.
  TITLE     Tracing the evolution of antibiotic resistance in Staphylococcus
            aureus
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2648450)
  AUTHORS   Lee,L.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2013) Faculty of Pharmacy, Universiti Teknologi
            MARA, Level 7, Block FF3, Bandar Puncak Alam, Selangor 42300,
            Malaysia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: CLC Genomics Workbench v. September 2012
            Expected Final Version            :: no
            Genome Coverage                   :: 500.0x
            Sequencing Technology             :: Illumina GAIIx
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003569945.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 03:29:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,610
            CDSs (total)                      :: 2,561
            Genes (coding)                    :: 2,485
            CDSs (with protein)               :: 2,485
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 42
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 33 of 76
            Pseudo Genes (incomplete)         :: 41 of 76
            Pseudo Genes (internal stop)      :: 18 of 76
            Pseudo Genes (multiple problems)  :: 13 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:46:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1214331
            Orig. end                         :: 1238562
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ984531.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Pharmacogenomics Lab, Universiti Teknologi
            MARA. Source DNA available from Pharmacogenomics Lab, Universiti
            Teknologi MARA.
FEATURES             Location/Qualifiers
     region          1..24231
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24231
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14231](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14231)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    2..18
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.4"
                     /tool="antismash"
     misc_feature    complement(323..337)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 24.73"
                     /tool="antismash"
     gene            971..1270
                     /locus_tag="AHP18_RS05790"
     CDS             971..1270
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095392.1"
                     /locus_tag="AHP18_RS05790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_000095394.1"
                     /transl_table=11
                     /translation="MSSKDAKKSQEEARLQQLKQEMRNSTDNMVSNAKNNVALKSQTLN
                     EIIETINNSSQNLESTFEGKASEAAQQSINKLKNNNENLKQKFESLLNTMKING"
     gene            complement(1507..2745)
                     /locus_tag="AHP18_RS05795"
     CDS             complement(1507..2745)
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072563.1"
                     /locus_tag="AHP18_RS05795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_072508197.1"
                     /transl_table=11
                     /translation="MSNTQKKNVPELRFPEFEGEWEEKQLGEVAKIYDGTHQTPKYTNE
                     GIKFLSVENIKTLNSSKYISEEAFEKEFKIRPEFGDILMTRIGDIGTPNIVSSNEKFAY
                     YVSLALLKTKNLNSYFLKNLILSSSIQNELWRKTLHVAFPKKINKNEIGKIKINYPKKQ
                     EQQKIGKFFSKLDRQIELEEQKLELLQQQKKGYMQKIFSQELRFKDENGNDYPEWENVM
                     LQKVLKDKTEGIKRGPFGGTLKKDIFIESGYAVYEQRNAIYDISNFRYYINENKYKEMQ
                     SFSVQPNDIIMSCSGTIGRLSLIPQNFTKGIINQALIRFRTNHKIRSEFFLIFMRSNQM
                     QRKILEANPGSAITNLVPVKELKLIPFPLPVKFEQDKISQFILIINRRIEQSEKKIESL
                     KNRKQGFLQKLFV"
     CDS             complement(2738..>3123)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028656.1"
                     /locus_tag="AHP18_RS05800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-6 DNA methylase"
                     /protein_id="WP_162889420.1"
                     /transl_table=11
                     /translation="YGTSIPTCILVFKKCRQQDDNVLFIDASNDFEKGKNQNHLTDAQV
                     DRIIDTYKRKETIDKYSYSATLQEIADNDYNLNIPRYVDTFEEEAPIDLDQVQQDLKNI
                     DKEIAEVEQEINAYLKELGVLKDE"
     gene            complement(2738..>3125)
                     /locus_tag="AHP18_RS05800"
     misc_feature    3108..3122
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.81"
                     /tool="antismash"
     assembly_gap    3126..3288
                     /estimated_length=163
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     CDS             complement(<3289..4123)
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_function="GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028656.1"
                     /locus_tag="AHP18_RS05805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_205527104.1"
                     /transl_table=11
                     /translation="MIEHLATAIRKVETSTLGEESENDFIGLFSDMDLSSTRLGNNVKE
                     RTALISKVMINLDDLPFVHSDMEIDMLGDAYEFLIGRFAATAGKKAGEFYTPQQVSKIL
                     AKIVTDGKDKLRHVYDPTCGSGSLLLRVGKETKVYRYFGQERNNTTYNLARMNMLLHDV
                     RYENFDIRNDDTLENPAFLGNTFDAVIANPPYSAKWSADSKFENDERFSGYGKLAPKSK
                     ADFAFIQHMVHYLDDEGTMAVVLPHGVLFRGAAEGVIRRYLIEEKNYLEAVIGLPAN"
     gene            complement(<3289..>4127)
                     /locus_tag="AHP18_RS05805"
     assembly_gap    4128..4354
                     /estimated_length=227
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<4355..>4533)
                     /locus_tag="AHP18_RS05810"
                     /pseudo=""
     CDS             complement(<4355..4533)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028656.1"
                     /locus_tag="AHP18_RS05810"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="type I restriction-modification system subunit M
                     N-terminal domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDLRGNMDASEFRNYILGLIFYRFLSEKAEQEYADALAGEDITY
                     QEAWADEAYREDLK"
     misc_feature    complement(4896..4907)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.09"
                     /tool="antismash"
     gene            4932..5501
                     /locus_tag="AHP18_RS05815"
     CDS             4932..5501
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016170789.1"
                     /locus_tag="AHP18_RS05815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4888 domain-containing protein"
                     /protein_id="WP_072508199.1"
                     /transl_table=11
                     /translation="MNTKLLGKTLVASALVLTTLGTGLHSSYLGLDTNKVVKTAKAEEN
                     MTNGELWKKVKDSLKDSNIISGNDGESVKVTFLTKDGHSTHVESTANHDTVTNTPSNFS
                     KLTQIDITKENIPANDFNTRLDANEAWHNITKKLHESGLVKNGEKVTIATKDPKDPQIS
                     GTVGSDMTDHKGYMLNKRDINKITIE"
     gene            complement(5916..6614)
                     /locus_tag="AHP18_RS05820"
     CDS             complement(5916..6614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500445.1"
                     /locus_tag="AHP18_RS05820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BsaG protein"
                     /protein_id="WP_072508200.1"
                     /transl_table=11
                     /translation="MIINELKSCKLKFSKQALTFIPIIVTILFILFINWYLNVNEWNGR
                     QISLYTASFNAITSLLISINVYQVINFEENIGHFNHILGKANRLNWLNASIIFTYTITA
                     ICILLASINLLWHSHDMKITLMFIGVSLFFNVIILLLLFIFSIFIKDVLAIVVGVLMFI
                     FNVYFGLEVLGDHSWFYLPITYATRYVYMYIEGNIPVMMTMVIYIIITLLLAVLLFKGF
                     NKWSGRTIKD"
     gene            complement(6611..7372)
                     /locus_tag="AHP18_RS05825"
     CDS             complement(6611..7372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500446.1"
                     /locus_tag="AHP18_RS05825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_119024958.1"
                     /transl_table=11
                     /translation="MIHLKIEGIKFKNSFSMYVLLISPLVFLCFAIFTVLFAKSNTGTA
                     NSVSPYITLLFNIWPIAFIPIVLCMACNSLFKIEMRNKSFNYYLSNNWSITKEIRAKIA
                     ILSLSFLGHCFLVYIIAYIGDLIINPHPVNAMLLLVTILLMYVVSLPLIPLNFLLTRYF
                     GVFVSILINLVLSVVCVIFLTLKSLFWVLPWAIMQRIPLVTLGILPNGLVVNHNSKYFN
                     DLNALYISIIISIFLFAILTFLNNKKSWRLK"
     gene            complement(7369..8061)
                     /locus_tag="AHP18_RS05830"
     CDS             complement(7369..8061)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500447.1"
                     /locus_tag="AHP18_RS05830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic protection ABC transporter
                     ATP-binding subunit"
                     /protein_id="WP_072508201.1"
                     /transl_table=11
                     /translation="MAKLVTENISKRFKNQDVLKHINITLENSEVYGLLGINGAGKTTL
                     MKIICGILQQDSGEILLDNQPMKRNDLHKVGSLIETPATYNHLSAQDNLKIVCLNESVD
                     FSEINSVLSLVNLNVDKKKKVKDFSLGMKQRLGIAMALIKKPEILVLDEPSNGLDPYGI
                     QELRELLKLLTEQGTSIIISSHILSEIQVLADHIGIIHEGELKYQQRNNKDENLEDIFF
                     KITKGDYK"
     gene            complement(8084..9457)
                     /locus_tag="AHP18_RS05835"
     CDS             complement(8084..9457)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500448.1"
                     /locus_tag="AHP18_RS05835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_072508202.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.4e-44, bitscore:
                     148.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTIKRVLINLIILSLLISITMSTAIASEEQYYSVEYKNTAIFSK
                     LVKKNSLNVVYNIPELHVAQIKMTKTHAKALANYKNDIKYINATCSTCMTSEKTIDRTS
                     NESLFSRQWDMNKITNNGASYDDLPKNANTKIAIIDTGVMQTHDDLKNNFSMDSKNLVP
                     LNGFRGTEPEETGDVHDVNDRKGHGTMVSGQISANGRLIGVAPNNKFTMYRVFGSKKTE
                     LLWISKAIVQAANDGNQVINISVGSYTILDKNEHQTFRRDEKVEYDALQKAINYAKKKK
                     SIVVAAAGNDGIDVSDKQKLNIQREYQGNGEVKDVPASMDNVVTVGSTDQNSNLSEFSN
                     FGMNYTDIVAPGGSFAYFNQFGMDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKV
                     SGALALIIDKYHLEKHPDKAIELLYQHGTSKNNMPFSRYGHGELDVYKALNVANQKAS"
     gene            complement(9467..9985)
                     /locus_tag="AHP18_RS05840"
     CDS             complement(9467..9985)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500449.1"
                     /locus_tag="AHP18_RS05840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphopantothenate--cysteine ligase family
                     flavoprotein"
                     /protein_id="WP_072508203.1"
                     /sec_met_domain="Flavoprotein (E-value: 7.1e-29, bitscore:
                     97.5, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGENVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFVN
                     GEILKQFCDNYYDEFENPFLNHVDIANKHDKIIVLPATSNTINKIANGICDNLLLTICH
                     TAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPANISESYELASKTFKKNVVAP
                     EPYKVLEFI"
     gene            complement(10001..11245)
                     /locus_tag="AHP18_RS05845"
     CDS             complement(10001..11245)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500450.1"
                     /locus_tag="AHP18_RS05845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_072508204.1"
                     /sec_met_domain="LANC_like (E-value: 6e-82, bitscore:
                     272.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLNLILKKKFQEVSEVDDFISKVATETDYFEPSTLSHGIPGII
                     LFLDAYQKVFDINTEQIVYKFVMKLAPYLQNGQYNNSLFGGLSGIAFSMDIASQNGRNY
                     QKILNNIDDVIVNEIESDIDQILQEPLNPLNYDSISGLAGIGRYLLNRIDVSDKNVKAL
                     KSILTYFKNIQYSQNSWVVPQESQFLESDKNYFTQGNINLGLAHGVLGPMSLFALCMIK
                     GITIEKHQQILKDMYKYIMDEKFSSNDRWLQRYDLISERNHFNYIRNGWCYGNTGVMTT
                     LFLIGQALQDDEIIQISKKVMLQVVNDKEKNLISPTVCHGLSSQILMLTNMNLHFELNE
                     VSDYINELINKLMSHYKEDHLVNFIDINENNEGVFKSEKVGLLEGEIGVYLTLMTLQNT
                     NILNEKNWTNAFLIS"
     gene            complement(11238..14231)
                     /locus_tag="AHP18_RS05850"
     CDS             complement(11238..14231)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500451.1"
                     /locus_tag="AHP18_RS05850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_072508205.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.6e-149,
                     bitscore: 495.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.3e-13,
                     bitscore: 47.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-23, bitscore:
                     78.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKE
                     SILTTTFNLYRTLQKINFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINIGHFVN
                     EPTRLKVGNSIQKYVKVDGEWLYKLISYIESNDEYYQNLKVIWNNKAHIVNDRIYLNEQ
                     SAIYLNNNKDTSFSIKNSELLMFIKTTVMHNNITFSNLAEKINQEFEIHDISKVKAYIH
                     NLVSKEIIYSTIRPPLTNNDNLNYILNKLSLHNDDYVEKIREIQKLISAYEKTAIGFGE
                     KLYKDIVQHMKALFKCKNYLQIDTKIDMINNQLHQDIATNISEAAYLLWLLSRNNIGFT
                     DLKVLHNRFIEKYGFEQLVNVKDLLSDITGFGTTIFQEDETEGNNIVMLKQKFLHALKN
                     SDEIVINEKDVESLINDNEINHYHAPMSADVYAEIYLGRFYNQYNELIVISPITVSLNA
                     GATFGRFHHLIDTETLEKLEHEKAHYYQKMMRDDNVEMISLNNIPKYPRNHNVLTNHDS
                     YEYSLNLGSSNSDSKYEVNLDDIYVGSTFNKLYLYSCQLNKRLLFESNNMFNFLKESNL
                     YRLLREISMESVKSIEPMNDVSIDSFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEW
                     DQQFLKYKQQFNIPTMVNLVYGDNKLLLNLSLDNHRYLLMKEYKKHKRVRLVETFLPQS
                     KNDYVYEIVTPVFKKTAYCGPEIEIPKYKNTDIEYDKEWFALHIYIDKSSQNTFIVDKL
                     YPFVKRLKEDKYIDKYFLMRYIKQGDFLKLRFYRNDENYNEIYSILKDWLSFVRQTTEV
                     SDYEFVSYEPEFFRYGGKNTINEIESFFEYDTNLAVNIIEKDFKFERPFIVAVSIMYLF
                     EKLAVTFDERMEIVNNYVPTSYKSKEIRPFKNELVMISNPSNNFENMDKHYSNIYQVLK
                     NGDQILNNLNEGLKQSLTTKKSRIIGSLIHMRCNRIFGIDKDQETFVLSIVKEIVKTQK
                     HWCGDKND"
     aSDomain        complement(13521..13799)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AHP18_RS05850_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.90E-15"
                     /identifier="RREFam001.1"
                     /label="AHP18_RS05850"
                     /locus_tag="AHP18_RS05850"
                     /protein_end="237"
                     /protein_start="144"
                     /score="47.0"
                     /tool="antismash"
                     /translation="VIWNNKAHIVNDRIYLNEQSAIYLNNNKDTSFSIKNSELLMFIKT
                     TVMHNNITFSNLAEKINQEFEIHDISKVKAYIHNLVSKEIIYSTIRPP"
     gene            complement(14296..14439)
                     /locus_tag="AHP18_RS05855"
     CDS             complement(14296..14439)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="AHP18_RS05855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_000432510.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.5e-20, bitscore:
                     70.1, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 7.7e-09, bitscore:
                     32.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENVLDLDVQVKAKNDTSDSAGDERITSFIGCTPGCGKTGSFNSF
                     CC"
     CDS_motif       complement(14377..14439)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENVLDLDVQVKAKNDTSDSA"
                     /locus_tag="AHP18_RS05855_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14296..14376)
                     /prepeptide="core"
                     /locus_tag="AHP18_RS05855_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="3.70"
                     /molecular_weight="2533.9"
                     /monoisotopic_mass="2532.1"
                     /core_sequence="GDERITSFIGCTPGCGKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENVLDLDVQVKAKNDTSDSA"
                     /leader_location="[14376:14439](-)"
                     /alternative_weights="2551.9"
                     /alternative_weights="2569.9"
     gene            complement(15165..15308)
                     /locus_tag="AHP18_RS05865"
     CDS             complement(15165..15308)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500452.1"
                     /locus_tag="AHP18_RS05865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_047437384.1"
                     /sec_met_domain="TIGR03731 (E-value: 4.8e-20, bitscore:
                     68.5, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 1.6e-07, bitscore:
                     28.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVLDLDVQVKGNNNTNDSAGDERLTSYSLCSFGCEKTGSFNSF
                     CC"
     CDS_motif       complement(15237..15308)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKVLDLDVQVKGNNNTNDSAGDE"
                     /locus_tag="AHP18_RS05865_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15165..15236)
                     /prepeptide="core"
                     /locus_tag="AHP18_RS05865_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="0.40"
                     /molecular_weight="2368.7"
                     /monoisotopic_mass="2367.1"
                     /core_sequence="RLTSYSLCSFGCEKTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKVLDLDVQVKGNNNTNDSAGDE"
                     /leader_location="[15236:15308](-)"
                     /alternative_weights="2386.7"
                     /alternative_weights="2404.8"
                     /alternative_weights="2422.8"
     misc_feature    complement(15393..15406)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.88"
                     /tool="antismash"
     misc_feature    15406..15423
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            complement(15730..16713)
                     /locus_tag="AHP18_RS05870"
     CDS             complement(15730..16713)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500453.1"
                     /locus_tag="AHP18_RS05870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="leukocidin/hemolysin toxin family protein"
                     /protein_id="WP_047437382.1"
                     /transl_table=11
                     /translation="MKIKTLVKSSVATSVALLLFSNSVEAAQHITPVSEKKVDDKITLY
                     KTTATSDNDELNISQILTFNFIKDKSYDKDTLVLKAAGNIHSGYKKPNPNDSNYSYFYW
                     GAKYNVSISSESKDSVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGISGGGNGSKS
                     FSETINYKQESYRTTIDRKTNHKNIGWGVEAHKIMNNGWGPYGRDSYHSTYGNELFLGG
                     RQSNLNAGQNFLPTHQMPILSRGNFNPEFISVLSRKQNDAKVSKVKVTYQREMDRYTNY
                     WNQLHWIGNNYKSQNIATFTSTYEVDWEKHTVKLLDTYSKETNPGA"
     gene            complement(16715..17650)
                     /locus_tag="AHP18_RS05875"
     CDS             complement(16715..17650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_114304764.1"
                     /locus_tag="AHP18_RS05875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="beta-channel forming cytolysin"
                     /protein_id="WP_047437380.1"
                     /transl_table=11
                     /translation="MVKKKILAATLSVGLIAPIASPYQDSRANTNIENIGDGAEIIKRT
                     EDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGKGYELTKRMIW
                     PFQYNIGLTTKDSNVNVINYLPKNKIESADVGQTLGYNIGGNFQSSPSIGGNGSFNYSK
                     TISYTQKSYVSEVDKQNSKGVQWGVKANSFVTPDGQKSAHDRYLFVQSPNGPTGSAREY
                     FVPDNQLPPLIQSGFNPSFITTLSHEKGSSDTSEFEISYGRNLDITYATFFPRTGIYAE
                     RRHNAFANRNFVVRYEVNWKTHEIKVKGHN"
     misc_feature    17729..17745
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.24"
                     /tool="antismash"
     gene            18523..18999
                     /locus_tag="AHP18_RS05880"
     CDS             18523..18999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001795597.1"
                     /locus_tag="AHP18_RS05880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_223804875.1"
                     /transl_table=11
                     /translation="MFRGGEGMAKLDLNSLDDEHIKLLINELKYPTTQIDVNELKTIVA
                     SRINERQEIISFKLGIKYFLTIKRGNIEKDRFSISIIFEDTYHTLVRIDINGGTHHNPD
                     GTIAPKSHIHIYNDKYDKKDRFAYEINLKDFPDIYNLYNVYMSFLEYNNIKDLE"
     gene            19012..19800
                     /locus_tag="AHP18_RS05885"
     CDS             19012..19800
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500456.1"
                     /locus_tag="AHP18_RS05885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1828 domain-containing protein"
                     /protein_id="WP_047437375.1"
                     /transl_table=11
                     /translation="MTTFDAEKLKKEYLDWYNQTLEFSNLSNNVVRIDTPFKDNSLDNL
                     IIYALYDQSRDMITLTDDGYTLFDLENNGISLNKSKKRKKIFEEHLSAYGIKYNDKTNE
                     IFVQTNFKNFNKSKHNLLQCLIFVNDMYLLSNPKSQNIFTEDVANKLDEHNIYYGRDLP
                     IIGSSGVVHNFDFFISAKKNQKEKFINAISNPNNSMIIKSKITDALQAKKIKRHRQNEF
                     IFILNDSKKEINEHNKNLLHENYIRTIDYSELDEKIGLLI"
     gene            19978..20100
                     /locus_tag="AHP18_RS05890"
     CDS             19978..20100
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016133.4"
                     /locus_tag="AHP18_RS05890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /protein_id="WP_072508207.1"
                     /transl_table=11
                     /translation="MTRVRRTYIKDFKLQMVKLYENGKSRNEVIREYDLTLSTF"
     gene            <20574..20738
                     /locus_tag="AHP18_RS13655"
                     /pseudo=""
     CDS             <20574..20738
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002456358.1,RefSeq:WP_011082735.1"
                     /locus_tag="AHP18_RS13655"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="YLIFFKEHLYNTYQND"
     tRNA            complement(20914..21002)
                     /anticodon=(pos:complement(1235296..1235298),aa:Ser,
                     seq:gga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Ser"
     gene            complement(20914..21002)
                     /locus_tag="AHP18_RS05900"
     assembly_gap    21077..21338
                     /estimated_length=262
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     tRNA            complement(21370..21443)
                     /anticodon=(pos:complement(1235740..1235742),aa:Gly,
                     seq:tcc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gly"
     gene            complement(21370..21443)
                     /locus_tag="AHP18_RS05905"
     tRNA            complement(21459..21534)
                     /anticodon=(pos:complement(1235830..1235832),aa:His,
                     seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-His"
     gene            complement(21459..21534)
                     /locus_tag="AHP18_RS05910"
     tRNA            complement(21548..21620)
                     /anticodon=(pos:complement(1235916..1235918),aa:Phe,
                     seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Phe"
     gene            complement(21548..21620)
                     /locus_tag="AHP18_RS05915"
     tRNA            complement(21637..21712)
                     /anticodon=(pos:complement(1236008..1236010),aa:Asp,
                     seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Asp"
     gene            complement(21637..21712)
                     /locus_tag="AHP18_RS05920"
     tRNA            complement(21728..21801)
                     /anticodon=(pos:complement(1236096..1236098),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AHP18_RS05925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Met"
     gene            complement(21728..21801)
                     /locus_tag="AHP18_RS05925"
     gene            complement(22198..22752)
                     /locus_tag="AHP18_RS05930"
     CDS             complement(22198..22752)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500457.1"
                     /locus_tag="AHP18_RS05930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_031787920.1"
                     /transl_table=11
                     /translation="MTDVIIVHSMHGNSRNHWYQWLEHNLTLEGYDVTLFNFESPETKT
                     VDQWVEAMTKQINVRKKDTYFVTHGLGSITALKYIEMIDQPIEGFFSIAGFKEDAEKID
                     LDIDLSNVTIDYDNIKKKVDHFYGLSSKNDKYVSYKETQRLMNALEGNIRIVEDGGHFL
                     EEDGFETFTALQDRMQDYMTR"
     misc_feature    complement(23061..23073)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    complement(23208..23223)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: strong, score: 30.17"
                     /tool="antismash"
     misc_feature    complement(23647..23659)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    complement(24198..24212)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 atgattcaaa aatacgcaat attggccatt ttgatgatcc tattaataaa ttgaattttt
       61 ttaatcctcg tattggcaaa aatattacag caatgccaca ttatgatgga tttataactg
      121 cccttccttt gattggtcaa cacacaattg aatcttacaa tgatttcgat gcagatggta
      181 atgtgaagga aatgccagaa cttgaacaat ttaatgatga tccatctctt actaatagat
      241 ttcaattatt tgacccattt ggtataaata gcagattttt cgactctatt aaaatcgata
      301 gttctatatt aaatagaaca agtgaaaatg attttgatcc ttttgctatt ctcaataaaa
      361 aagataaatt attcgaatca aatgattttg atatagaagg atttaataat aaacaaaaag
      421 aagatttaag tattgattta aatccttttg atgatgacga tccattaatt cccaaaagag
      481 acgatagaaa aaaattaaaa gcagaaaaag aaagctctgt taaaaaaggt aaaggtggtt
      541 ccaaagattc aggcaaaaaa gtaaaaattc agcctgatga agtgcgtaat atcgctaaca
      601 caatccgtga tagactattt ttgtatactc aaataattac tgcattggat gaatatagag
      661 aagaaacaat atcagggggt aatcgcattt tagataaata tcaatcggag cttctaagcg
      721 gtccacatga atttataaca ccttatgatc ttgaacaata tatggagatt ttagcagttg
      781 agggaagttt aggaaatttc aagttttata ataatggttt aatggatgac ttaattcaag
      841 aattagatca aaacaaaaaa gacttgttac aatttgctga aaaactagaa tttgctgcaa
      901 ataaattcga agaaaaagat ttagaagaaa gcgatgtttt tggattattt agttaaagag
      961 ggtaattaaa atgagctcaa aagatgcaaa aaaaagtcaa gaagaagcta gattgcaaca
     1021 attaaagcaa gagatgcgta atagtactga taatatggtt agcaatgcta aaaataatgt
     1081 agcattaaaa tctcaaacat taaatgaaat cattgaaaca attaataatt cttcgcaaaa
     1141 tttagaaagt acatttgaag gaaaagcaag cgaagcagcc caacaaagta taaataaact
     1201 caaaaacaat aacgaaaatc ttaaacaaaa atttgaatcc ctattaaata caatgaagat
     1261 aaatggataa tatagaggta ttatttattt aactgtactt ttttacacat tacgaaaatc
     1321 ccctcgctaa acaaatagtg aagggatttt aatttagttg tttgtattta ttaaaaatga
     1381 ttattactga atttttaatc tgctgtttga tattaaataa tactttaaaa tatgagtaat
     1441 tatcattatg ccactgagca atatattatt ataaaatctt ctaatatttc tattgctaat
     1501 ctaaatttaa acaaataact tttgaagaaa tccttgttta cgatttttta gactttcaat
     1561 ctttttttca gattgttcaa tacgtcgatt tataataagt ataaattgac taattttatc
     1621 ctgttcaaac tttacaggta atggaaatgg gattaatttc aattctttta caggcactaa
     1681 attggttatt gccgaccctg gatttgcctc taggattttt ctttgcattt gattgctcct
     1741 cataaatatc aaaaagaatt cacttctaat tttatggtta gttctaaatc taataagcgc
     1801 ttggtttata attccctttg taaaattctg aggaatgagt gataatcttc caatagtacc
     1861 tgagcagctc attattatat catttggctg aaccgaaaat gattgcattt ctttatattt
     1921 attttcgttt atataatatc taaagttact tatatcatag attgcattcc tttgttcata
     1981 aactgcataa ccgctttcta taaatatatc tttctttaat gttcctccaa aaggtcctct
     2041 ctttatacct tcagttttgt ccttcaaaac tttttgaagc attacatttt cccactctgg
     2101 ataatcatta ccattctcat ctttaaatcg caattcctgt gagaagattt tctgcatata
     2161 gccttttttc tgttgttgaa gtaattcaag tttttgttct tctagttcaa tttgtcggtc
     2221 gagtttgctg aagaacttac ctattttttg ttgttcttgc tttttagggt aattaatttt
     2281 aatttttcca atttcatttt tgtttatttt tttgggaaat gccacatgta aagtttttct
     2341 ccataattca ttctgaatag atgacgataa aattaaattt ttcaaaaaat aggaattaag
     2401 attcttagtt tttaataatg ctaagctaac atagtaagca aatttttcat ttgaactcac
     2461 tatgtttggt gtacctatat caccaattcg agtcattagt atatctccga attctggtcg
     2521 gattttaaac tctttttcaa atgcttcttc cgaaatatac ttacttgaat tcaacgtttt
     2581 tatattttct actgacaaaa attttatacc ttcatttgta tatttaggag tttgatgagt
     2641 accatcatat attttggcta cttcccctaa ctgcttctct tcccattcgc cttcaaattc
     2701 tgggaacctc aactctggca catttttctt ttgtgtatta ctcatctttc aacaccccaa
     2761 gttctttcag gtatgcattg atttcttgtt caacttctgc gatttctttg tcgatatttt
     2821 tcaaatcttg ttggacttga tctaaatcaa ttggcgcttc ttcttcgaat gtatcgacgt
     2881 atctcggtat gtttaagttg taatcgttat cggcaatttc ttgtaatgtc gcgctgtagc
     2941 tatatttatc aatcgtttct ttacgcttat atgtgtcaat aatgcgatcg acttgggcat
     3001 cggttaaatg gttttgattt ttcccttttt caaaatcatt ggatgcatcg ataaataata
     3061 cattgtcgtc ttgttggcga cattttttaa atactaaaat acaagttgga atacttgttc
     3121 catagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat tggctggtaa
     3301 gccaatcacg gcttctaagt agttcttttc ttcgattaaa taacgacgaa tgacaccttc
     3361 tgcagcacct cggaataata cgccatgtgg taatacaaca gccatcgtac cttcatcatc
     3421 taagtaatgt accatgtgtt gaataaaggc aaagtcggct ttagactttg gcgcaagttt
     3481 gccgtaaccg ctgaagcgtt cgtcattttc aaattttgaa tctgctgacc atttcgcact
     3541 gtatggtggg ttcgctataa ccgcatcaaa tgtattgcct aaaaaggctg gattttccaa
     3601 cgtgtcatca ttacggatat cgaagttctc ataacgcaca tcatgtaaca acatgttcat
     3661 acgtgctaag ttgtatgtgg tattgttacg ttcttgccca aaataacgat acactttcgt
     3721 ctctttacca acgcgtaaaa gcaatgaccc tgaaccacac gttgggtcat acacgtgacg
     3781 taatttatct ttaccgtctg tgacaatctt cgccagtatc ttagatactt gttgtggtgt
     3841 atagaactca cctgcttttt tacccgctgt cgccgcaaaa cgcccgataa ggaattcgta
     3901 tgcatcgcct aacatatcaa tttccatgtc gctgtgaacg aatggtaaat cgtcaagatt
     3961 aatcataact tttgagatta acgcagtacg ttctttaaca ttgttaccta aacgcgttga
     4021 acttaagtcc atatcgctga acaaaccaat aaagtcattt tcactttctt cacctagtgt
     4081 tgatgtttca actttacgaa ttgccgtcgc cagatgttcg atatcgannn nnnnnnnnnn
     4141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngctttt aaatcttcac ggtatgcttc
     4381 atctgcccat gcttcttgat acgtgatgtc ttcacctgcc aaggcatctg catattcttg
     4441 ttccgctttt tcagatagga agcgatagaa aatcaagcct aaaatgtaat tacggaattc
     4501 actcgcatcc atattccctc ttaaatcatt cgcagcgatg tggagaattt tgatgataaa
     4561 aatggaaagt tattattata aaatcatgga tggaaaattt ttgtagtcgc gttgtaaatt
     4621 tttcgaatcc tcttaaaatc atctgaagtt tcaatggtat taaataaatg cacatctata
     4681 cataagtaga acaaataatt gtattcgttc aaatcatttt atttacattt atattcccta
     4741 aaacacttat caacattact atttctcatt attctttatg attggaacaa aaaattatat
     4801 caaaaaatta ttctaacttt aagttaatag tcatttaata catttgttat ttttagttaa
     4861 ttgtttttct aaaatattat tattatattt gcattgtaaa cgtttacaat ataaaaaaag
     4921 gagcaattaa aatgaataca aaattgttag gtaagacatt agtagccagc gcattagttt
     4981 taacgacatt aggaacagga ttacattctt catacttagg attagataca aataaagttg
     5041 ttaaaacagc aaaagcagaa gaaaatatga caaatggaga attgtggaag aaagtcaaag
     5101 actccttaaa agattcaaat ataataagtg gtaatgatgg tgaatctgtt aaagtaacat
     5161 ttctaactaa agatggacat tcaacgcatg ttgaatcaac agccaatcat gatacagtca
     5221 ctaatacgcc aagcaatttc tcaaaactaa ctcaaataga tataacaaaa gaaaatattc
     5281 cagccaatga ttttaataca agacttgatg ctaacgaagc gtggcataat ataactaaaa
     5341 agttacacga aagtggccta gtcaaaaatg gtgaaaaagt aacgatagct actaaagacc
     5401 ctaaagatcc acaaatctca ggaacagtag gttctgatat gactgaccat aaaggttaca
     5461 tgttaaataa acgtgacatc aataaaatca caatcgaata aataaattct taataccctt
     5521 tcttacaaac cacctaaccc ataatagatt aaaatgtcat tgattattta aaatagcgga
     5581 taaaataaaa aaccattccg cataaacttt ggcaagttgg aatggttaaa aaaatatttt
     5641 tagaagccag cgtttggctt actaagacga catgttcgcg catgtcgtct tatttttaca
     5701 tctatataat aacacgcaat tcaataaaat gtctatccaa taaatcacaa ttgcattcaa
     5761 gctcaaaaac tttgcattta aagaatcaga cataatcaat cgcgcctaat accccttctg
     5821 tccaaatgca aaatcatttt gcattattgt ctatcaattc tcttttctcc ctttttaaca
     5881 caactaaact ccatttttca ccagctccac aattcctagt ctttaatcgt tctgccactc
     5941 catttattga atcctttaaa gagtaaaact gccaataaca acgtgataat aatatagatt
     6001 accattgtca tcatcaccgg tatatttcct tcaatataca tatatacata acgcgtagca
     6061 tatgtgattg gtaaatagaa ccacgaatga tctccaagca cttctaatcc aaaatatacg
     6121 ttaaatataa acattaaaac gccgacaaca atagccaata catctttaat gaaaatacta
     6181 aaaataaaaa gtagcaataa tataatgaca ttaaaaaaca atgatacacc tataaacata
     6241 agtgttattt tcatatcatg tgaatgccat aataaattaa ttgatgctaa tagaatacat
     6301 atggctgtaa ttgtataagt aaaaatgatt gatgcattta accaatttag cctattagct
     6361 tttcctaaaa tatgattaaa gtgaccaata ttttcttcaa aattgatgac ttgatagacg
     6421 tttatagaaa ttaatagtga tgtaattgca ttaaaactcg ctgtatacaa gctaatttgt
     6481 cgaccattcc attcattcac gtttaaatac caatttataa ataatataaa tagtatggtt
     6541 acaataatag gtataaatgt aagtgcttgc ttagaaaatt tcaacttaca tgactttaat
     6601 tcattaatta tcattttaat cgccaacttt tcttattatt taaaaatgtt aatattgcga
     6661 aaagaaagat gcttataata atcgaaatat ataatgcatt gagatcatta aaatattttg
     6721 agttatgatt tacaactaaa ccattaggta atatgccaag tgttacaagc ggtattctct
     6781 gcatgatcgc ccatggcaat acccaaaata aactttttaa tgttaaaaat atgacacaaa
     6841 cgactgataa tactaagttt attaatattg atacgaacac cccaaagtat cttgttaata
     6901 aaaagttgag cggtattaat ggtagtgata caacatacat caacaatatt gtcaccaata
     6961 acaacatagc attaaccgga tgcggattaa tgataaggtc acctatataa gcaataatat
     7021 atactaaaaa gcaatgtccc aaaaatgata atgataaaat ggcaatcttt gctcttattt
     7081 cttttgtaat tgaccaatta ttacttaagt aataattaaa tgatttattt ctcatttcaa
     7141 ttttaaataa cgaattacaa gccatacata atacaattgg aatgaatgca attggccaaa
     7201 tattaaaaag taaggttata tatggtgaaa cactattcgc tgtacctgta ttacttttgg
     7261 cgaataagac tgtgaaaata gcaaaacaaa gaaataccag tggacttatt aataaaacat
     7321 acatactgaa agaattttta aatttgatac cttctatctt taaatgtatc atttgtaatc
     7381 tcctttcgtt attttgaaga atatatcttc taagttttca tctttgttat ttctttgctg
     7441 gtattttagc tcaccctcat gaataatacc gatatgatct gctaaaactt ggatttcaga
     7501 taaaatgtga cttgaaataa tgatactagt accttgttct gttaataatt ttaaaagttc
     7561 tctaagttct tgtattccat atgggtctaa accattagat ggttcatcta atactaagat
     7621 ttctggcttt ttaattaacg ccattgcaat tccaagtcgt tgtttcatac ctaaagaaaa
     7681 atctttaact tttttctttt tatcaacatt taaattgact aaacttaaaa cactattaat
     7741 ttcgctgaaa tcaacacttt catttaaaca cacgattttc aaattatctt gtgcacttaa
     7801 atggttatac gtcgcgggtg tttcaataag cgaaccaact ttgtgtaaat cgttgcgttt
     7861 catcggttga ttatctaaca atatctctcc agaatcttgt tgaagtatgc cacaaataat
     7921 tttcatgagt gtcgttttac cagcaccatt aatgccaagt aacccataaa cttcgctatt
     7981 ttctaaagtg atattaatat gctttaatac atcttgattt ttaaaccgct tcgaaatgtt
     8041 ttcagtaact aattttgcca taatcaaaaa ctcctttgac ttattaactt gctttttgat
     8101 ttgctacatt taatgcttta tacacatcaa gctcaccatg tccataccta ctaaatggca
     8161 tattattctt ggaagttcca tgctgatata acaattcaat cgctttatct ggatgttttt
     8221 caagatgata tttatcaatg attaaagcta gcgctcccga aactttaggt gtggctaatg
     8281 aagttccagc ctgataaata tatcttccgt tattggcagt agttaaaatg ttctccttat
     8341 gcatataccc ttcattcatc catttatcca tgccaaattg attaaaatat gcgaatgaac
     8401 ctccaggcgc aacaatatca gtataattca taccaaaatt ggaaaactca gagagattac
     8461 tattttgatc tgttgatcct actgtaacga cattgtccat agatgcagga acatctttta
     8521 cttcgccatt tccttgatat tcacgctgta tatttagttt ctgtttgtca cttacatcaa
     8581 taccatcatt accagctgca gcaacgacga tagacttttt cttcttggca taattgattg
     8641 ctttctgtaa agcatcgtat tctacttttt catctcttct aaaagtttga tgttcatttt
     8701 tgtccaaaat agtataacta ccaacactaa tattaatgac ttgatttcca tcatttgcag
     8761 cttgaacaat cgcttttgat atccaaagca attctgtctt tttactacca aacacgcgat
     8821 acattgtaaa tttattattc ggtgcaacac ctatcaatct accatttgca cttatttgac
     8881 ccgaaaccat agtgccatgt cctttcctat cattgacatc atgaacatca cctgtctctt
     8941 ctggttcagt acctctaaag ccgtttaaag gtactaaatt tttagaatcc atcgagaaat
     9001 tatttttcaa atcatcatgt gtttgcatca cacctgtatc tatgattgct attttagtgt
     9061 tagcattttt tggcaaatca tcatacgatg caccattatt tgttatttta ttcatatccc
     9121 attgtcttga aaacaatgac tcatttgatg ttctgtctat tgttttttca ctcgtcatgc
     9181 aagttgaaca tgtggcattt atatatttaa tgtcattttt ataatttgcc aatgccttag
     9241 catgcgtttt cgtcatttta atctgtgcca catgtaattc cggtatatta tagacaacat
     9301 ttaaggaatt ctttttaact aacttgctaa atattgctgt atttttatat tcaacactgt
     9361 aatattgctc ttctgacgct attgcagtac tcattgtaat agaaattaaa agactcaata
     9421 ttattaaatt aataagcacg cgctttatgg ttttcatctt cttatctcaa atgaattcca
     9481 gaactttata tggttctggt gcgacaacat tctttttaaa tgtttttgac gctaattcat
     9541 aactttctga aatatttgct gggtatattg atacaccata atcttttaat aatcgaatat
     9601 tattttgagt aactggattt tcccacatgc gtaaattcat atttggaaat attgaaagtt
     9661 tttcaaaagc tgtatgacaa atagttaata ataaattgtc acatatacca tttgcaattt
     9721 tattaatcgt atttgatgtc gcaggtaaaa caataatctt gtcatgttta tttgctatat
     9781 ctacgtgatt taaaaatgga ttttcaaatt cgtcataata attatcacaa aattgcttta
     9841 atatctcacc attaacaaac tttctgccat ttgttgatgc aattacattt acttcatcaa
     9901 attttgattt caattcaata atatagtggc taatgttgat actatttact gatccacaca
     9961 aacaaatcaa tacattttct cccataatat acgcctccat tcagctaatt aaaaacgcat
    10021 ttgtccaatt tttttcattg agaatatttg tattttgcaa tgtcatcaat gttagataaa
    10081 cccctatttc accttctaaa aggcctactt tctcactttt aaatacgcct tcattattct
    10141 cattaatgtc tataaaattc accaagtgat cttccttata atgagacatc aatttattta
    10201 ttaattcatt aatataatca gaaacttcat ttagttcaaa atgcaaattc atgttagtta
    10261 acattaatat ttgtgaagat aatccatgac aaacagtagg acttattaaa tttttctcct
    10321 tatcatttac tacttgtaac atcacttttt tagaaatttg aataatttca tcatcttgta
    10381 atgcttggcc gattaagaac aacgtcgtca ttacacccgt attaccataa caccaaccat
    10441 tccgaatata attgaaatga ttacgttcgg aaattaaatc gtaacgctgt aaccatctat
    10501 cattgctact aaatttttca tccataatat atttatacat gtcttttaat atttgttgat
    10561 gtttttcaat agtaatccct ttaatcatgc ataatgcaaa taacgacatt ggtcctagca
    10621 ctccatgcgc aagaccaaga ttgatattgc cttgtgtaaa ataattctta tcagactcta
    10681 aaaattgact ttcttgtgga actacccagc tattttggga atattgaatg tttttaaagt
    10741 atgttaatat gctttttaat gcctttacgt ttttatcact tacatctatt cgatttaata
    10801 aatatcgacc tatcccagct aagccactaa tagaatcata atttaatgga tttaatggtt
    10861 cttgtaatat ttgatcaata tcactttcta tttcattcac aatgacatca tcaatattat
    10921 ttaaaatttt ttgataattt ctgccatttt gtgatgctat atccattgaa aatgcaatac
    10981 ctgaaagtcc accaaacaaa gaattgttat attgaccatt ctgtaaataa ggtgctaatt
    11041 tcatgacaaa cttatacaca atttgctcag tatttatatc gaaaactttt tgataagcat
    11101 ctaaaaataa aatgatacct ggtataccat gtgataaagt tgatggttca aaataatcgg
    11161 tttccgtagc tacttttgaa ataaaatcat ctacttctga aacctcttga aacttcttct
    11221 tcaaaattaa attcaaatca gtcattttta tcaccacacc aatgcttttg agttttaaca
    11281 atttctttta caatagataa aacaaaggtt tcttggtcct tatcaatgcc aaatattcga
    11341 ttgcaacgca tatggattaa actaccaata atccttgatt ttttcgtagt taaagattgt
    11401 ttaagtcctt catttaagtt atttaaaatt tgatcgccat tttttaaaac ttgatatata
    11461 ttactatagt gtttatccat attttcaaag ttattagaag gattagatat cattacaagt
    11521 tcatttttaa aaggtctaat ctctttactt ttatatgaag taggtacata gttattaaca
    11581 atttccatac gttcatcaaa agtaactgcc aatttttcaa ataaatacat aatcgataca
    11641 gcaactataa atggtctttc aaacttaaaa tctttttcaa taatattgac agctaaattc
    11701 gtgtcatatt caaaaaagga ttctatttca ttaatcgtgt tctttccgcc atatctaaaa
    11761 aattctggct catatgatac aaattcataa tctgaaactt ctgtcgtttg acgaacaaat
    11821 gataaccaat ctttcaagat gctgtatatt tcattataat tttcatcatt cctataaaac
    11881 ctcaacttta aaaagtcacc ttgtttgata tagcgcatta aaaaatattt atcgatatat
    11941 ttgtcctctt ttagacgttt cacaaaagga tacagcttat caacaataaa tgtattttgc
    12001 gaagatttat cgatataaat atgtaatgca aaccattctt tgtcatattc aatatctgta
    12061 tttttatatt ttggaatttc aatttcaggt ccacaatatg cagttttttt aaaaacaggt
    12121 gtaacaattt catacacata gtcattcttt gattgaggta aaaatgtttc tactaaacgc
    12181 acacgtttat gtttcttata ttctttcatc aataaatatc tatgattatc taatgataag
    12241 tttagtagaa gtttgttatc tccatatact agatttacca tagtgggtat attaaattgt
    12301 tgtttatatt ttaaaaattg ttgatcccat tcttcatttt tgggtaaagg tagcaccatt
    12361 tcattaattt tccagtatgc tggtttaaga attacatttt tatatcggat tcgcggtgaa
    12421 taactaaatg aatcaatgct tacatcattc ataggttcaa tacttttcac cgattccatt
    12481 gaaatttctc ttaacaaacg atataaatta ctttctttta aaaagttaaa catgttgtta
    12541 gattcaaata ataacctttt atttagttgg caagaatata aatataattt gttaaaggta
    12601 gaaccaacat aaatatcatc taagttaacc tcatactttg aatcactatt actacttcct
    12661 aaattcaatg aatattcgta tgagtcatga ttagttaata cattatgatt tcgtggatat
    12721 ttcggtatgt tatttaaaga aatcatttct acattgtcat cacgcatcat cttctgataa
    12781 taatgtgctt tttcatgttc taatttctct aaagtttcag tgtcaattag atgatgaaag
    12841 cgcccaaatg tagcgccagc atttaacgaa actgttatag gactaataac aatgagctca
    12901 ttatactgat tgtaaaaacg tcctaaataa atttcagcat aaacatctgc actcattggc
    12961 gcatgataat gattgatttc attatcatta atcaatgact ctacgtcttt ttcattgatg
    13021 actatctcat cgctattttt caaggcatgc aaaaattttt gcttaagcat tacaatatta
    13081 tttccttcgg tttcgtcttc ttgaaaaatt gttgtcccga aacctgttat atcagaaagt
    13141 aaatctttaa cattaacaag ttgttcaaat ccatactttt caataaaacg gttgtgaaga
    13201 actttcaaat ctgtgaatcc aatattattt cttgataaaa gccacaataa gtacgctgct
    13261 tcagatatat ttgttgcaat atcttggtgt aattgattgt taatcatgtc aattttggta
    13321 tcaatttgaa gataattttt acatttgaat aacgccttca tatgctgaac aatgtcttta
    13381 tataatttct caccaaatcc aattgctgtt ttttcataag ctgatatcaa tttctggatt
    13441 tctctaattt tttccacata atcatcatta tgtaaagaaa gtttatttaa aatataattt
    13501 aaattatcat tatttgttaa tggtggtctg atcgttgaat atataatttc cttcgagaca
    13561 agattatgaa tatatgcttt tactttagaa atatcatgaa tttcaaattc ttgatttatc
    13621 ttttcagcta aatttgaaaa agtaatgtta ttatgcatca cagttgtttt gatgaacatg
    13681 agtaattcac tatttttaat ggaaaaagat gtatctttat tgttgtttaa ataaatagca
    13741 ctttgctcat ttaaatatat tcgatcattg acaatatgtg ccttattatt ccaaataact
    13801 ttcaaatttt gataatattc atcattactc tcaatatagc taatcagttt atacaaccat
    13861 tcaccatcga ctttcacata tttttggata ctatttccaa ctttaagacg tgtgggttca
    13921 tttacaaaat gccctatatt aataccactt aataatccaa atggcgttgg acgtgttgac
    13981 attctaatta aatattttaa taaactctct ttagcatctc taaccttctt gttatcacca
    14041 tcaaaattta ttttttgtaa agtacggtat aagttaaatg tcgttgttag aatcgattct
    14101 ttcatctgag catttaattg taagtcgcta tatttaattt gttcagtatt taaaaataaa
    14161 ttaaaaaact caactgataa taaaggtgtt ctaatcatac aaatacttga cggttcgtaa
    14221 attgtgttca tttgtaagca cctcacatat ttgaatagac aaatagagcc ctttcaggct
    14281 ctatttgcta tagtcttaac agcagaagct attaaaacta ccagtcttac cacaaccagg
    14341 agtacaacca atgaaactag taatacgttc gtcacccgct gaatcagaag tgtcgttttt
    14401 cgcttttact tgtacgtcta aatcaagaac attttccata gataatacct cctattaaaa
    14461 gttgaagtta aggcccactt caattgtcat attatccctt tttgcacaac aaatcaataa
    14521 attatataat tttattttgt gaattttttg taaacactta tttatttagt aatactattt
    14581 tgaatattag atttttgcgt ttttttatta ctatttattt tcactaataa ttttacatct
    14641 aagtatataa atttaaattt attgttgaat tttttaacag attaatcatt ttgtttataa
    14701 aaatgcttag gataattatg tcactaattt aattgatata tatagggatt aagtgagaat
    14761 actttgtaga tattaatgtg tttttgattg atttatttaa acatataaaa aatgaatata
    14821 tgaagatact ttaatggtga ggatataaat atttcaataa cttgattgtc tttttaaatg
    14881 acatgttcta agagattcaa tttaataatc aaaacttgtt attacttata tgtagatata
    14941 gaggctaatt ttataatact aacttttttt ataggaagtc atgaaaacta tattaaaagt
    15001 attacttttt atcaccaaag tcagagtgta ttgaaaaact caaacggtaa taaagatgaa
    15061 taatcataaa aatacatgac agttagtaaa ctgttttcgt tttttagcac ttaatataat
    15121 taaatagaca aatagagccc tttcaggctc tatttgcagt acccttaaca acagaagctg
    15181 ttaaaactac ccgtcttttc acaaccaaag ctacataaag aatagctagt aagtctttcg
    15241 tcacccgctg aatcattagt gttgttattt cctttaactt gcacgtctaa atcaagaact
    15301 ttttccatag ataaagcctc ctatttgaag ttgaagttaa ggcctacttc aattgtcata
    15361 ttatccattc taaaataaca aatcaacatg atttataata attatttgtt attaatttgt
    15421 aaatcatcat taattttatg gtactattat tattttttat cgctaattat cactgctaat
    15481 cgatttgtat ttaagttttt atatatttaa attaggtcat gtatatatta agagttaagt
    15541 ctttttatat gttagaagtt tttaaataat tctactgccg ccaatttagc aacctaatat
    15601 ttagcaaagt tatctacgtt tcccttacta aaaatcatca tgcgtgtaaa taaaaattat
    15661 gttaattcat taaaaccatt agataattga aataattgca cattgttgat tgtttaagca
    15721 tgtacaaccc tatgctcctg gatttgtttc tttagaatat gtgtctaata attttacagt
    15781 gtgcttttcc cagtccactt cataagtaga tgtaaacgta gctatatttt gacttttata
    15841 attattacca atccagtgta attggttcca atagttcgta tatctatcca tttctctttg
    15901 atatgtcact tttacttttg ataccttggc atcattttgt tttcgtgaaa gaacacttat
    15961 aaattcaggg ttaaagttcc cacgcgataa tatcggcatt tgatgtgtag gtaagaaatt
    16021 ttgtcctgca tttaaattac tttgtctacc acctaaaaat agctcgttac catatgttga
    16081 atgataactg tctctaccat atggtcccca accattgttc atgattttat gtgcctcgac
    16141 accccaacct atatttttat gatttgtttt tctatcaata gtagttctat agctttcttg
    16201 tttgtaatta attgtttctg agaatgattt tgatccattt ccaccacctg atattccatt
    16261 agaaatatta atatctccac cataagaata tcctaatgtt tgttgaactt gaaattcttc
    16321 attttgattt ttaggcgcat aatccactac attcacagaa tctttagatt cagaacttat
    16381 tgaaacatta tactttgctc cccaataaaa gtatgaatag ttactatcat taggatttgg
    16441 ttttttatat cctgaatgaa tatttccagc agctttaagt actaatgtat ctttatcgta
    16501 acttttatct ttaataaaat tgaaagttaa aatttgagaa atgtttaatt catcattatc
    16561 tgatgttgct gtcgttttat ataatgttat tttgtcatct actttctttt cacttactgg
    16621 tgtaatatgt tgagctgcct caactgagtt tgaaaataat aacaatgcaa ctgatgtagc
    16681 aactgaagat ttgactaaag ttttaatttt cattttaatt atgtcctttc actttaattt
    16741 cgtgtgtttt ccaattaact tcgtatctaa ctacaaaatt tctgtttgca aacgcattgt
    16801 gtcttctttc tgcataaata cctgtacgtg ggaagaatgt tgcatatgta atatctagat
    16861 ttctaccata tgaaatttca aattcacttg tatcacttga acctttttca tgagataacg
    16921 tagtaataaa tgatggatta aaaccacttt gaattaaagg tggcagttgg ttatcaggta
    16981 caaagtactc tcgtgctgaa cctgttgggc catttggact ttgaacaaat aagtatcgat
    17041 catgtgctga cttttgaccg tcaggagtaa caaatgagtt tgctttaacg ccccattgaa
    17101 caccttttga attttgttta tctacttcac taacataact cttctgggtg taactaatag
    17161 ttttagaata attaaatgaa ccgttaccac caatagatgg tgaggattgg aaattaccac
    17221 cgatgttata acctaatgtt tgcccaacat ccgctgactc tattttgttc tttggaagat
    17281 agttaattac attcacatta gaatctttgg ttgtaagtcc aatattatat tggaatggcc
    17341 aaatcattct tttagtcaat tcataccctt taccttttac atcagagaaa gaagttctag
    17401 aattgataaa accttgcatt ttaacaatta aagcatcttt gttatatttt ttgtctttaa
    17461 caaagtcgaa ttgaacattt tgagttacac cccatttctt actacttaca tcctcagtcc
    17521 ttttgattat ttcagcacca tcaccaatat tttcaatatt agtgttagct ctggaatctt
    17581 gataaggaga agctattgga gcaataagtc ctactgataa agttgcggct aatattttct
    17641 ttttaaccat ttaaaccact ttctttctat ataaattttt aatacaaatt tattttagtg
    17701 tatttcacta ttttataaaa ttaactgttt gttaaaagat aaaatcgtat aaaatattaa
    17761 tttagacaca atttattcaa ttaaaatgct caaatccgtt caattaaaag gttgattaga
    17821 aacttataca ttcgagtaat tacatgcgta aaacctaata acgttaacag tagtcaacta
    17881 ttttgctaat aaattcaaag cgaacttata ttaaatcttt aaagctgaag tttgtatttt
    17941 cacaaataat ctaaatttta atttaaaatt aactaattat taactttggt gattcaaaac
    18001 agacatgatt tcttttataa gattttaact taaatgagca atttaaaatt ttgaattgtc
    18061 ttttacttta tctgaaaaac ttaatagtgt gacaaagact aaccagttaa atgcattaat
    18121 ttactataaa ctgaaatttc actctaaaaa taaaaaacca tgatttcgaa atcttcatat
    18181 actgaagttt ctactctcat ggcaatttat actatgatat tcaattataa tgcctagtct
    18241 catagtaaac ggctactaca ttcgcatgta cttcgtttta ctgtccacgc atggtcgttg
    18301 acttatttat attataatat aaatatttta tttttcaata cttaaacata aaaatatctc
    18361 attctataaa atcattatgt tgatgagctg catctttaaa tctaatcata ccttgtataa
    18421 agttatattg cagaatacta atttaacaat ttacactttt gactgcgtaa gcatctcact
    18481 tattttttca ataagaaaga attaaaaata aaagcataaa ctatgttcag aggaggagaa
    18541 ggaatggcaa aacttgattt aaatagtctt gacgacgagc acataaaatt attaataaat
    18601 gaattaaaat atccaacaac tcaaatcgat gttaatgaat taaaaacaat agttgccagt
    18661 cgaataaatg aaaggcaaga aataataagt tttaagttag gaataaagta cttcttaaca
    18721 ataaaaagag gaaatataga aaaagatagg ttttcaatct caatcatttt cgaagatact
    18781 tatcacactc tagttagaat agatattaac ggtgggactc accataatcc agatggaaca
    18841 attgctccga aaagtcatat tcacatatat aatgataagt atgataaaaa ggataggttt
    18901 gcttatgaaa ttaacttgaa agatttcccc gacatctata atttgtataa tgtgtatatg
    18961 tcgtttttag agtataataa tataaaagac cttgaataaa ggaggtataa tatgactacg
    19021 tttgatgctg aaaaattaaa aaaagaatat cttgattggt ataatcagac cttagagttt
    19081 tctaatttat caaacaatgt agtaagaata gatactcctt ttaaagataa ttctttagat
    19141 aatttaataa tatacgcttt atacgatcag tccagagaca tgatcacact gactgatgac
    19201 ggctatactt tatttgattt agaaaataat ggtatttctt taaataaatc aaaaaaacgt
    19261 aaaaagattt ttgaagaaca cctttcagct tacggtatta aatataacga taaaactaac
    19321 gaaatttttg ttcaaactaa ctttaaaaat tttaataaat ctaaacataa tttattacag
    19381 tgccttatat ttgttaatga tatgtattta ctttctaatc ctaagtcaca gaacatattt
    19441 acagaagatg ttgcaaacaa attggatgaa cataacattt attacggaag agatttacct
    19501 attataggaa gtagtggtgt tgttcataat ttcgactttt ttattagtgc aaagaaaaat
    19561 caaaaagaaa aatttatcaa tgctatttct aatcctaata attctatgat tattaagtcg
    19621 aaaataacgg atgctttgca agcaaaaaaa ataaaaagac acaggcaaaa tgagtttatt
    19681 tttatattaa acgactcaaa aaaagagata aatgaacata ataaaaacct tcttcacgaa
    19741 aactatattc gtactataga ttatagtgaa ttagacgaaa agataggttt attgatttaa
    19801 tatttatggc cgtgataata acaatgttta ttttaaatga gaagaatttg aaaatttcaa
    19861 aacagattaa gatagcaaat tgaatagtct gatagataat gcagaatcgt ctacacttag
    19921 tcaaacaaat actatgagaa tagatattgt taaactagtt gggtaggcga ttttattatg
    19981 acaagagtca gaagaacata tattaaggat tttaaattac aaatggttaa actttatgaa
    20041 aatggtaagt ctagaaacga agttatacgc gaatatgatt taacactctc aacattctaa
    20101 aattggataa aacaacatca aatactgggt cattcaatta tcgagacaac ttaataagtg
    20161 atgataaata ttcataccat tttgcaaatg taaccagata ctctctacaa aatgtagagt
    20221 tcaaaattaa atatgtcaac attatagtaa atgagattaa aaaagcaaac aaaagataac
    20281 cccagggtca taagaattct caactttcgc ctactcctat tcggtaataa atcaaaaatc
    20341 attgaaactt taatcacata aattaatagt agtcccctgt tcgcagttct ataaattaca
    20401 aatgcaataa aggctaaagt aaactaatta ctttagcctt tataaataat ttagtcgaat
    20461 ttattaaaaa ttgactaact cctggttatg ctacgctttt ctttaaaatc cgcacgtaga
    20521 tgccgattga ttatattata acttttttta ttttattttt tcaacatata taatatttga
    20581 ttttctttaa ggaacaccta tacaatacat atcaaaacga ttaggtcatg cagatgtaca
    20641 tacaacgctt aaaacatatt cacatttgat taaagaattt gaagataatg aaactaaatt
    20701 tatagaaaaa acatctgaat gatttgtttt gtgactaaaa ttgagattaa taatcaaaaa
    20761 ttagtcacat tgtggctaaa aaattttaaa tggatataaa taaataagaa gtgtaaaaat
    20821 gaggataata gctcaaatgc agaaatatca agggtttgag tctaaaataa aaatagcgct
    20881 taaaatgatt tcaaaccatt ttaagcgcta aaacggagag tgagggattc gaaccctcga
    20941 gacgcttgtg gcgcctacac actttccagg cgtgctcctt cggccaactc ggacaactct
    21001 cctcaataat atatatgtaa taaaaaaaca gaagcgatat ttcacttctg tttgtatgac
    21061 tcctacggga ctcgaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    21301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct gagctactgt ggaataataa
    21361 taaaaataat ggagcgggtg atgggaatcg aacccacaac atcagcttgg aaggctgagg
    21421 ttttgccatt aaactacacc cgctaatgta aacgattatg gggcggctga aggggatcga
    21481 accctcgaat gtcggaacca caatccgatg tgttaaccac ttcaccacaa ccgccatgaa
    21541 ttaagaatgg ttcaggacag agtcgaactg ccgacacatg gagcttcaat ccattgctct
    21601 accaactgag ctactgaacc ttaatggtat taataatggc ggtctcgacg ggaatcgaac
    21661 ccgcgatctc ctgcgtgaca ggcaggcgtg ttaaccgcta cactacgaga cctattaaaa
    21721 ctatgtattg cgggaggcgg atttgaacca ccgaccttcg ggttatgagc ccgacgagct
    21781 accgaactgc tccatcccgc gctaatatta ttttgaatta cctaattaat ataccatatt
    21841 taaataccta aagtcaagaa ctttttgaat ttaatttaaa tattatctct taaataatta
    21901 cttaaatatc gtagcaacat gttctctgtt gaacacaaat attagtatat tcatttttgt
    21961 agtgtacgtc aacgacattt taaaagtttt ttgtgtaaaa aaacgcttct tattcccttt
    22021 tataatataa gtgtctaata gttgtcataa ttaatcataa aacattgaaa aagatgtagg
    22081 gaccttaaaa tttataatac ctacatcttc agctaattaa aatataatta tagtcatttt
    22141 cactaaaatg ctatgcctcc tgttgacata acacaacact gcgcaatcat acattcccta
    22201 gcgtgtcatg taatcttgca tgcgatcttg caatgctgta aatgtttcga agccatcttc
    22261 ttctaagaag tgccctccat cttcaacgat tcgtatatta ccttctaatg cattcattaa
    22321 acgttgagtc tctttatatg aaacgtattt atcattttta gaactcaatc cataaaaatg
    22381 atcgactttc ttcttaatat tatcatagtc gattgtcacg ttacttaaat cgatatctaa
    22441 atcaattttt tctgcatctt ctttaaaacc tgcaatactg aaaaatcctt ctatcggctg
    22501 atcaatcatt tcaatatatt ttagcgctgt aattgaacct aaaccatgag ttacaaaata
    22561 tgtatctttc tttcgaacat taatttgttt tgtcatagct tcaacccact gatctactgt
    22621 cttcgtttca ggtgattcaa aattaaataa tgttacgtca tatccttcta aagttaagtt
    22681 atgctccaac cactgatacc aatgatttct gctatttccg tgcatagaat gaacaatgat
    22741 tacatctgtc atctcattct ctcctttcaa catgctgtct ctttttctat tgttaaaact
    22801 tttactattt actaataatt gtaaaataaa agcaccttaa atagaaatgt ttatatctca
    22861 aattgacatt tcaaattaaa gtgctttgtc attttttcta ttaaatttag aaacaaatct
    22921 tactatgtgt atatattttt ataacaatta caatatttct gaatttccat caataaaaaa
    22981 catataaaga tacttcccta gcgtccttgt ccataattag cctaaagttc tgcaacaatt
    23041 tcttcagcag caaccttacc ttgcataata caatctggca atccaaccgc ttcaaatgaa
    23101 gcacctgtaa ctcgtagtcg tggatatgtc tgtttaatgt gagtttgtat atctctaatt
    23161 ttttgaatat gtcctacatg atactgtggc atacttttcg gcaaacggtt tacaattgta
    23221 aattcaggat cacctttaaa tgtcatcatt tgacttaaat ctttacgcac aattgaaact
    23281 aactcatcat cagtatgatc atcgaccaca gtgtcacctg gtttacctac ataggcacga
    23341 atcaacacct taccttttgg cgtagtaaat ggccattttt tcgatgtcca agtacatgcg
    23401 gtaatgtctg tatcacttgt tctcgcgata acgaagccag taccatcata ggtattttca
    23461 atatcttttt catcaaatgc caatacaact gtcgcaaccg ttgtactatc cattgtttta
    23521 aaataatcaa atgctggatc ttgaccaaac caatttaaaa atacttgatg tggtgtcgtt
    23581 actaatacgc catcatacac ttcttcaagt tgatcgttat aaacaatttt atattgcttt
    23641 tgagacgtga taatgtcatc cacttttgta ttatattgaa ttgatacacc cttatttttc
    23701 acatcttgtt ctaatgcttc aataaatgaa cttaaaccat gcttaaattg tttgaattgt
    23761 ccttttggtg caccaggata taattgtctt tgtttcagac gcttattttt ctcatccttc
    23821 atacctttga tcaaacttcc aaatgcctct tctttttctt taaaattagg aaacgtactc
    23881 atcaaactta atttatcaat atctgtacca taaataccac ccattaaagg ttcaattaaa
    23941 ttttcaagta cctcattccc taatctcgct ctgaaaaatg caccaacaga aatatcacca
    24001 tcctgcattt gaataggctt tttaagcaaa tccaatcctg ctcttaattt accaagtggc
    24061 gatattaatt ttgtagtaac aaatggttta atatctgttg gaattcccat aattgagcca
    24121 cctggaattg gatataattt atttttcgca aaaatataag attgtcctgt tgtatttgta
    24181 acaatgtcct gttctagccc tatatctttt gctaattctg tcattatagt t
//
