LOCUS       NZ_QSJW01000012        27839 bp    DNA     linear   CON 28-FEB-2024
DEFINITION  Blautia obeum strain AM29-25AC AM29-25AC.Scaf12, whole genome
            shotgun sequence.
ACCESSION   NZ_QSJW01000012
VERSION     NZ_QSJW01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Blautia obeum
  ORGANISM  Blautia obeum
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Blautia.
REFERENCE   1  (bases 1 to 113276)
  AUTHORS   Zou,Y., Xue,W. and Luo,G.
  TITLE     A genome reference for cultivated species of the human gut
            microbiota
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 113276)
  AUTHORS   Zou,Y., Xue,W. and Luo,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2018) BGI-CNGB, BGI, No. 11, Beishan IZ., Yantian
            Dist., Shenzhen, Guangdong 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina Hiseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/28/2024 19:09:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,731
            CDSs (total)                      :: 3,671
            Genes (coding)                    :: 3,600
            CDSs (with protein)               :: 3,600
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 10 of 71
            Pseudo Genes (incomplete)         :: 61 of 71
            Pseudo Genes (internal stop)      :: 10 of 71
            Pseudo Genes (multiple problems)  :: 9 of 71
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:03:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 85437
            Orig. end                         :: 113276
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QSJW01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27839
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27839
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27839
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:25817](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..25817
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            498..1733
                     /locus_tag="DW767_RS16265"
                     /old_locus_tag="DW767_16270"
     CDS             498..1733
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="DW767_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16270"
                     /product="radical SAM protein"
                     /protein_id="WP_025580259.1"
                     /sec_met_domain="Fer4_12 (E-value: 7.5e-14, bitscore: 45.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.8e-14, bitscore: 46.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.8e-13, bitscore: 42.3,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-13, bitscore:
                     44.2, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-06, bitscore: 21.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGYKYRVVEIGEYVLIIQREKNICFKMKKKEFEEEGDIKIREIID
                     GISKMRKKYDVTFPENKKQMNTIYLFVTDYCNLNCEFCAMRSNNKDIKKEKLSQLEVKE
                     HVIDKIRKANPRKLIVSGGEPFVLEDILDILKELKENINTKIIVQTNATLLTEKTIKSL
                     NGIINSIEISTAHYKNTEQLKEKIALLNKYKIDVVLTFTYQNEKEKMLLREIIDMAAYY
                     DADFLLHFVDYAGSAADRGYPLLNYQERLKVYCYFAKYIIEKGYTNKRFAGNLFHAVEL
                     SHPCSAFGKMAAFFPDGNIYLCHSLVKEKYRIGSIEQETDIEQSIEKILSNDNVEKLFY
                     MPNEKCKTCKFNCVCGGMCPALIEEGVDSDCTLRKIMFIYSMFIFDKNENIAINLERFI
                     KFCEEEEYQQFL"
     gene            1792..1935
                     /locus_tag="DW767_RS18950"
     CDS             1792..1935
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DW767_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173684410.1"
                     /transl_table=11
                     /translation="MLEHKENKELTEAEVNAYDLVIICYGKLRKDCLTDCLDGTYWLSP
                     EQ"
     gene            1939..4392
                     /locus_tag="DW767_RS16270"
                     /old_locus_tag="DW767_16275"
     CDS             1939..4392
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.4"
                     /locus_tag="DW767_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16275"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_025581297.1"
                     /transl_table=11
                     /translation="MLGKTHFQNQNLVLKMGFFVNLYRIEVGKMKGNNEKKVIGHLARQ
                     DLNSVRLKKFCGILTIILSTALIIVVTLYFVQTQRFSIQDAEGRYQATFMDVNSKVVNK
                     MKAMKNVEMGETRTLGTLNQGTYKITIRTMTESLLKLGRYPELKGKLPEMEKEVVVTDS
                     YLEEVQSKAKIGDSIEIDLGDGKESYVIAGILPMQSTADTHSIYVSDKLIERKMPGALY
                     SIYFKINDTQGWNEAGIKSEIDKIAQQLDVPKDSIVYSSYYFSLISQKSIQYISVILGV
                     SLVIAIISSIVIYSIFFVSVLERIGKYGQMRTLGMTKKQIRKIIKIEGNVLTLKGCFWG
                     CVFGGIIAYFIQPKGWYLVNTILISGMASAFVYFVVMLSLYKPAKIASAASPIEALRYF
                     ADTEVNINRKHSYKKITLWRLALLSVQRNKKKTFLTILSLGICGIVLMASSSYLNSIDP
                     YNMAKKSMPNGEIKIELGTYGPQSYTSKQYFDLQKNNILNQELLKKLEDMQAVESIKQY
                     KGTVCDITLPNGDTDIFVVDGIQSGDITNLKKFLVDGEIDFKKMQQKNGIVVSEASEWE
                     TLWDWEVKIGDTINILDSEGVPVKYEVVGIVENGADYGGYNMVYMPLSNMEELRKDVLN
                     LTYQLSIKTTSDTNVSKTEDMIRKMFQNEMPIQFTTIDDVAASYKQRIDAYRKPVYGLV
                     IFVGIFGIVNLLNMLFSNMATRKREYGMLQCVGLTDKQLSSIVVKEGILYSVGSISISL
                     IFGTIFGIILCNVFSSFSVFGKVIYHFPFKEMTVYFSILIIVQMIFAYIIINFYKRESL
                     IDRIK"
     misc_feature    complement(1956..1970)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 24.36"
                     /tool="antismash"
     gene            complement(4569..>4919)
                     /locus_tag="DW767_RS16275"
                     /old_locus_tag="DW767_16280"
                     /pseudo=""
     CDS             complement(4569..>4919)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015526860.1"
                     /locus_tag="DW767_RS16275"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16280"
                     /product="RNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="QRFQVGEHILVRILTIPGDSPETLSIHADVKIVEGNTSKENLKSC
                     RVQGKYAGTVEDIHKGTVFVRLELGVNAIAHSCYDSRTVGKKDKVSFVVTHIDEERNVA
                     VGIITRIIKQSI"
     gene            5141..5830
                     /locus_tag="DW767_RS16280"
                     /old_locus_tag="DW767_16285"
     CDS             5141..5830
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728879.1"
                     /locus_tag="DW767_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16285"
                     /product="response regulator transcription factor"
                     /protein_id="WP_025580962.1"
                     /transl_table=11
                     /translation="MRKDIIIIDDDRDLCTLLQESLLQENICADISCNGFDGIKSVKDK
                     EYQLVVLDVMMPGISGFEVLERIRDMSNVPILMLTAKDDSTSKVKGLRAGADDYLTKPF
                     EMEEFFARVLSLIRRYTRLNNMASKAILKYGDLRIDLESGIVELSGEELKLSAKEYDVL
                     IYLAKNQGKILTKKQIYENVWNEEYVYDDDNIMAVISRLRKKIERTAENSYIQTVRGLG
                     YRFNKEL"
     gene            5836..6753
                     /locus_tag="DW767_RS16285"
                     /old_locus_tag="DW767_16290"
     CDS             5836..6753
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="DW767_RS16285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16290"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_117843973.1"
                     /transl_table=11
                     /translation="MKLFYVVLVILLFYNLGLTLYVFKINRRLKEFNQILLEIEKGQSK
                     QKFLLKKNNRIDQVGFRVNSILYKYEKRIEESNIELEANKQLMTSLSHDVRTPMTTLIG
                     YLDALDLKLVSSDKEEQYLRLAKEKAYDLKKYIEVLFEWFRINSDEEQLEIKAVDITEE
                     TRRIFLDWIPIIEEHRIGYNIEIPEKAIIVEIDEDCYMRAINNIVQNIFTHSKAANISI
                     TASEGNGKFRLEIGDDGIGIAKEDLNYIFERLYRCNKGRSGKGNGLGLNISKLLLEKMG
                     GTISAFSEPGKGTVFCIEFSVIQR"
     CDS             6762..6860
                     /gene="allorf_092199_092297"
                     /locus_tag="allorf_092199_092297"
                     /protein_id="allorf_092199_092297"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIRSSIIFFVLNKLQGSCQVSVRFLSEKYIIL"
     CDS_motif       6762..6812
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIRSSIIFFVLNKLQGS"
                     /locus_tag="allorf_092199_092297_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6813..6860
                     /prepeptide="core"
                     /locus_tag="allorf_092199_092297_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="1762.1"
                     /monoisotopic_mass="1761.0"
                     /core_sequence="CQVSVRFLSEKYIIL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIRSSIIFFVLNKLQGS"
                     /leader_location="[6761:6812](+)"
                     /alternative_weights="1780.1"
     gene            6893..7816
                     /locus_tag="DW767_RS16290"
                     /old_locus_tag="DW767_16295"
     CDS             6893..7816
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016281052.1"
                     /locus_tag="DW767_RS16290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16295"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_055151469.1"
                     /transl_table=11
                     /translation="MSQYIIQTRDLTKTYGEQKSVSNLNMHVRKGKIYGLLGRNGAGKT
                     TTMKMLLNLIEPTSGSIRIFNRDIRLEEKKILPRIGSLIESPGFYPNLTGTENLRIFAK
                     LRGIPRTDAIEQALKLVNLPYKDKKLYSQYSLGMKQRLAIALAVMHDPEILILDEPING
                     LDPIGIAEIRTFIEDLSKNRGKTILISSHILSEIAVLADDIGIIDKGVLIEEGSMKELE
                     EKNGKYIHFKVSDNAQAARILSVYYKESNFKVSGNQDINVYNLSISIPDIVRSFVQEGV
                     DVMDAHLCEDTLEDYFKKVTGGEGIA"
     gene            7809..8618
                     /locus_tag="DW767_RS16295"
                     /old_locus_tag="DW767_16300"
     CDS             7809..8618
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016728877.1"
                     /locus_tag="DW767_RS16295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16300"
                     /product="ABC transporter permease"
                     /protein_id="WP_117843974.1"
                     /transl_table=11
                     /translation="MLDLVRCEFTKLKRRKITLMLIVLSCFFPLIVVMTTKNGMSGDLS
                     THYLKMRFDLSFTMTQGYGLVFLAPCLIGMLATILFFMERDNDTFKNIRTVPVTITKMI
                     LAKICVLFIYGTLFSLASVSFTIFFSWILKVGIIYDLAYKLGFSIIFGLVITIASLPIV
                     VIIVYFNKSYLVSTLLAFFYSILNWGIIGLFETMAVKGTAKFLNLFPVICAMDWTSGKL
                     VDHVIKDNLSKEAYIMFPSDIYAFLVLGVTLFLSLMLMIRFYKKWTR"
     gene            8624..9409
                     /locus_tag="DW767_RS16300"
                     /old_locus_tag="DW767_16305"
     CDS             8624..9409
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015574362.1"
                     /locus_tag="DW767_RS16300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16305"
                     /product="ABC transporter permease"
                     /protein_id="WP_117843975.1"
                     /transl_table=11
                     /translation="MGNIISTELLKIKRYSVVKAGLVMMSLSVLMSCFYSIASTNKVWD
                     FQYFIQQVIISNCTLFFPIIITLVAVYIISRETTDDTLKSILTVPISYKKLLIAKFWLL
                     LFLTIVFSIFNALLSICFNAFLGFSGMNIHMMLMSAAQIIVSDILVYISVLPIIIVCAF
                     AEGKSLLGVAVAFIYGYFATMEGSMLNWFPIKAAMILVDPKCGSEYGITYKIPPAAMSI
                     IGVLVVSILLFQMLNRTKKNVYMKSKRKVKVKQTRRKGW"
     misc_feature    complement(9597..9611)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.68"
                     /tool="antismash"
     gene            9684..9884
                     /locus_tag="DW767_RS16305"
                     /old_locus_tag="DW767_16310"
     CDS             9684..9884
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="DW767_RS16305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16310"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_025580957.1"
                     /transl_table=11
                     /translation="MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSD
                     GSQFCTSTKECNWGTIMFVCC"
     CDS_motif       9684..9824
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS"
                     /locus_tag="DW767_RS16305_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9825..9884
                     /prepeptide="core"
                     /locus_tag="DW767_RS16305_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="2129.5"
                     /monoisotopic_mass="2127.9"
                     /core_sequence="QFCTSTKECNWGTIMFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEP
                     RVSDGS"
                     /leader_location="[9683:9824](+)"
     gene            10001..13138
                     /locus_tag="DW767_RS16310"
                     /old_locus_tag="DW767_16315"
     CDS             10001..13138
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="DW767_RS16310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16315"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_173684412.1"
                     /sec_met_domain="DUF4135 (E-value: 1.2e-103, bitscore:
                     340.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.6e-57, bitscore:
                     187.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNNCDNNSYFYERNYYKDVPIKDTQILEYWNNILGKDVIESID
                     KAYGVSIEQILFSEYSLNHKYISFATLNQEYSDMCNEKAISYLTKKGTKVLFDQFVLRF
                     LGYGKRVLERKSRKGYIVKVIQDCFLKNLAERILDVSLSTLIFEMYLAKEQGELRGNDE
                     AEEYNDYNQRFLGNDKYIKELFSIYPGLKRMLIELMENLANNYILLQERMEKDTLLLED
                     KFGGKKSWTEVKDIRTSGSDSHKKGNSVFLIQFQDGTKIVYKPHGLKVEKAYQSFLEFI
                     SSNCKKDFRQFLILDCGDYGWEEFVVNLPCNSEAEVRNYYYRIGVLVFCNYILNVNDIH
                     TENLIANGGYPVVVDAETVLDNKRDKKKKSGREKIYDKIHESVLYSGVLPFYKYTKNGK
                     GINMSALNGQEGEQYPILIPRLKNAGTSNMHYEYERPITQASNNLLRLGEKVKEPNQYI
                     DEICEGFFDAYTFCLDNKKLILNYVSIFENIEVRHLVQDTQRYSMLLHTSYNPDFLQDA
                     KDRQLFLCAVLKNVEQMQGNMEIAKLEIKDMLNMDIPYFYSNTSKEDLYGSEGEVVKNY
                     FAESSIQHLRNKICSMGKKDREEQIRFIKIILTDLNDVKVEKPKKDINELCISRSDNEH
                     GQKEYKKNAILKILHTLEQKAFYGDDGQDINWIGITSIGNSENSSWNIQPLGVYLYEGL
                     GGIALFYNALQQSDFDVDLSAACKAFETMMFQYTDDMLERSTDLEKESSGAYAGEASVI
                     YVYEVLYKITGKQKYLEYAEKHCKILEYALKADENNDLIYGNAGAVIVLLNLYHLAQKD
                     IYLQLACEAGNILIKNQNKGKWCCGNGQSLSGLSHGITGIIYALTKLNNEQFHIEYQKA
                     IHSGLIYENTMYSDKYNNWLDNREEAKKEENSDNRCMAAWCHGAPGILLARSKMYNLVK
                     DSSDYITVQCDIERALFATKMYGFTDNDCLCHGNLGNTEILLEYSKECNDEEVRHMMLS
                     ARTQIAMDIINENYDCARSYLHGYKIPGFMTGISGMGYSLLRDLYPELPCILALEI"
     gene            13181..15277
                     /locus_tag="DW767_RS16315"
                     /old_locus_tag="DW767_16320"
     CDS             13181..15277
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="DW767_RS16315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16320"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_025580955.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4e-30, bitscore:
                     97.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKKVHYVSQLGSMDCGIACLTMILNYYGCKSDIVDIGAEIQIG
                     RDGMTLAQMKELAEKYGFKFAAYQYNHEEKNLIEYLPAILCNDSHYVVVDKTKKKGKYI
                     LFDPANGKRVVDFLELKNGYKDILVSVIPSRNIKKIKKTKFKIEVKFSQFMIAIMLMLM
                     CQLITLAVPMVVQKVIDSLSSAHITIHIWKITLLVLLIMCAHFVLSLLRQKILLNINMK
                     LFKTMISNMIHKIFRLDVSFFEWHSAGDIGNRFNSINQLNDILTNGFINIIIQGITSLV
                     CLAVMTSISPYLTAFVLVVSIIQIAIMILLNGKNLIKTKEYIYSQSTIQGELIDTLENI
                     MEIKCMGMDNAVKSNLQNSYSKLIERFKGKTRISNLMNSFSSTLNLIFPLMIYVIGSYS
                     VKQGGLTIGQLIAYATLVGYFTAPFTTVVLLLPSINSIKEVLLRYKELMIFRENYHTGV
                     LVPGKFENLKISSVSYCYNSGQAYALNNVSLDLRRGERIAIVGLSGSGKSTLIKAILGA
                     VDINQGCIEINNYDIRSMSKEQIYKWFSVVTQNPMCLNASIRKNIDIIGDAPDEKIWKV
                     LDIVALKEEVLSMPLGLDTLVGEGGQNISGGQKQRIAIARALLSDTEVVIFDEATSNLD
                     QLTEKKIYDNLRSTNKTQIIITHRLSSIRDTDYIYVLNRGSIIEQGTHLDLMKKKGWYF
                     ESIQ"
     gene            15332..15997
                     /locus_tag="DW767_RS16320"
                     /old_locus_tag="DW767_16325"
     CDS             15332..15997
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DW767_RS16320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DW767_16325"
                     /product="hypothetical protein"
                     /protein_id="WP_025580954.1"
                     /transl_table=11
                     /translation="MKKKEIVIGVSVLISASLPISVYAASNESMSSRGFIIDETNEFED
                     IVKQILDVKSKHPEWSEQQISDFMDQIHAIKKDGVIDIWNALTSSEKKLVIRYPFDALK
                     VNKAKEIATKQTERKFGKNGLGDRSDAFRHGIWNAEMTVLIGSEKAELFATAHEDKDTT
                     GNESDGYTKDEHKKMDLHNNEIGRKLGADNLSAPEEKMAEIIYDEIMREDSLFVWLHE"
     gene            complement(16678..17607)
                     /locus_tag="DW767_RS16325"
                     /old_locus_tag="DW767_16330"
     CDS             complement(16678..17607)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015526860.1"
                     /locus_tag="DW767_RS16325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16330"
                     /product="hypothetical protein"
                     /protein_id="WP_059085305.1"
                     /transl_table=11
                     /translation="MANETMNLNTPILTLDSDTVLETAQSKADLIWHDIQNAYRTRKIL
                     TGILGGIEKTEAGSLIAIIYYKDYRAVIPISEMMINLIQDETHDYGDFSLRQNKVLNNM
                     LGSEIDFVIKGLDTKSRSIVASRKDAMLKKRQIFYFDQDSSGQNKIHEDRIVQARVIAV
                     AEKVVRAEIFGVETSILARDLSFDWLGDARERFQVGEHILVRILAIQGDSPETLSIHAD
                     VKSVEGNTSKENLKNCRVQGKYAGTVEDIHKGTVFVRLELGVNAIAHSCYDSRTVGKKD
                     KVSFVVTHIDEERNVAVGIITRIIKQNI"
     gene            complement(17633..19639)
                     /locus_tag="DW767_RS16330"
                     /old_locus_tag="DW767_16335"
     CDS             complement(17633..19639)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223624.1"
                     /locus_tag="DW767_RS16330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16335"
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_025579348.1"
                     /transl_table=11
                     /translation="MNRKWWKFLFLLPISVCTLYAGGYAAQFIKNYQEWTSAGNFAGNG
                     TYPQAASLHPLVCFHTALTDFPYNLYGIFLCLVLFGLLTFLLMRMGYDRNGEISDHDRN
                     LNYSTKGTYGTSGFMTPDEMMKVLELTGDVKKNKGTILGKLNGKAVCLPYQTRMNKNIA
                     VYGASGSMKSRAFARNMIFQCVARGQEGNNASGESLIITDPKSELYESMSAYLENEGYV
                     VKAFNLVNPENSDSWNCLGEINGQETMAQVFADVIIQNTGSGKGDHFWDNAEMNLLKAL
                     VLYVDQGFPPEARNIGQVYKLLTMSSEKELNSLFDLLPVSHPAKVPYCIYKQASDTVRS
                     GVIIGLGARLQVFQNKLIRQITSYDEIDLTLPGKQKCAYFCITSDQDSTFDFLSSLFMT
                     FIFIKLVRYADKYGEEGKLPVAVHILADELANTGAILELNKKISVIRSRNLSISCIFQN
                     LPQMQNRYPYNQWQEIIGNCDTQLFLGCTDEVTATFISNRSGDVTVGVSSEAKQLNSWR
                     VSDYTPEYRQTKSIGKRKLLTPDEILRLPLDTALVILRGQKVLKVEKYDYTLHPDAKKL
                     TPRKASEHIPEWRKNGSSEETEYRPQPSPGSAKRKRRSSSASIAKQKPHFTSEPVYQEP
                     TPDDFMEDFFQENFIEDSPDSGMVPLDKDSIMS"
     gene            complement(19629..20735)
                     /locus_tag="DW767_RS16335"
                     /old_locus_tag="DW767_16340"
     CDS             complement(19629..20735)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223623.1"
                     /locus_tag="DW767_RS16335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16340"
                     /product="hypothetical protein"
                     /protein_id="WP_226854332.1"
                     /transl_table=11
                     /translation="MIKTDSIKYQLLEMVGLCGEFPSGQLNRLIESDSYAEKVVTDLKQ
                     SKLIRTHYKDGLRGYRLTKRAKELLLSQNPCRFQNYLTGNAETNLIRSELPRRLRLHQK
                     AETYLTLSHAGIPFFPDEKPLLFSESSEAATFPVRSLPLFYSSREIKNLGASTTKIKNS
                     RCIGILMAPHCVYAVYNTGNTLLKWEYKTEVRLNAFLQHYLQGLPYHGPPTVYAIMTGS
                     DMDMAFRLLTSTGGYKKTLFMLDTSYEHFYFLPNNSYGEYLLRLLVQPQRMMQLNQLLL
                     SDCFPQREDLPIEHDGIDSQENPILLAYDFDMQRINRFNTGLNVYGLSGNLICFDFQLP
                     CLKKYLTADIHFSSIDFQKFKRRFFNEP"
     gene            complement(20875..21540)
                     /locus_tag="DW767_RS16340"
                     /old_locus_tag="DW767_16345"
     CDS             complement(20875..21540)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005340398.1"
                     /locus_tag="DW767_RS16340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16345"
                     /product="DUF6100 family protein"
                     /protein_id="WP_025579351.1"
                     /transl_table=11
                     /translation="MNTKTVFDRLQSIDDEVQKLHNTIFALKTTDIQAYADKYEELSIS
                     AALRSERIACQLRNLVYTTTDTGKKDYLKQAAAVQGIKISFSNSVLSITMPGLLPKRKL
                     RTNTAFLHEPLNLALQTYVTEHSIPLYKRCVVCFSQIYDQSLSLQRIRDYDNLEFKQIL
                     DTIASYVLVDDTGLFCDSYHTTELGNYDHTVIFVMEPEIFPGWLKDRKESIKTISEIS"
     gene            complement(21548..22078)
                     /locus_tag="DW767_RS16345"
                     /old_locus_tag="DW767_16350"
     CDS             complement(21548..22078)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223618.1"
                     /locus_tag="DW767_RS16345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16350"
                     /product="DUF5697 family protein"
                     /protein_id="WP_054338136.1"
                     /transl_table=11
                     /translation="MKTRNEIYQGEGAQLLRFITTYHSLQYEQVLRLFSKNRESIKSLI
                     TSLVKQKRIIYDKENGLLFDSQESANNPDYGMIASFWVLLDFKTAIVYHTDGEFPVKLN
                     FFSKDEWYEVLYVPQEQEYLINHVMESQTKSDAKRLVVLETEEQAAKIHITGVIAFCLV
                     DSSTGSVSYYAKK"
     gene            22479..22652
                     /locus_tag="DW767_RS16350"
                     /old_locus_tag="DW767_16355"
     CDS             22479..22652
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223616.1"
                     /locus_tag="DW767_RS16350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16355"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_114002469.1"
                     /transl_table=11
                     /translation="MRKFDRTNMKYNNPAGDLLTELEAADLTSNKVDSLASSGVVCTIS
                     VECGSIFTLACC"
     CDS_motif       22479..22553
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRKFDRTNMKYNNPAGDLLTELEAA"
                     /locus_tag="DW767_RS16350_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       22554..22652
                     /prepeptide="core"
                     /locus_tag="DW767_RS16350_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="3061.5"
                     /monoisotopic_mass="3059.5"
                     /core_sequence="DLTSNKVDSLASSGVVCTISVECGSIFTLACC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRKFDRTNMKYNNPAGDLLTELEAA"
                     /leader_location="[22478:22553](+)"
                     /alternative_weights="3079.5"
                     /alternative_weights="3097.5"
                     /alternative_weights="3115.6"
                     /alternative_weights="3133.6"
                     /alternative_weights="3151.6"
     gene            22707..25817
                     /locus_tag="DW767_RS16355"
                     /old_locus_tag="DW767_16360"
     CDS             22707..25817
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="DW767_RS16355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16360"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_117843977.1"
                     /sec_met_domain="DUF4135 (E-value: 8.1e-103, bitscore:
                     337.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.9e-67, bitscore:
                     219.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKSSYLSERVYDAIPSEINMESLEYWKKILKEEGLQYVKKNHLE
                     YFFGFINNCAFSSHEKSQPRNFVKLSLNKKAFRHEGEKMVFGAFYDPFVQEANRQLREI
                     VIQRRYINESILFDFQQFLFNSLNNLCIRTLIYEMHICGQEGVLRGNESEQYQYYIDHF
                     LKDKQYLNDLFSLYPVLERRINEIIQNAIDIYKEVIERIEKDADVLMKKFNITEKGFVV
                     NHLSTDFSDSHKKGRRVFCVEFVSGDKILYKPRSLQNEIKLQEITNYFYRICNLGSYEY
                     SILDKEMYGWCEIVIQRDCKSIEELSRYYQRIGIILFINYLLEGGDIHFENLIACNEYP
                     VIIDAETFIGNIEENNGKSAAEKVASLLRKSVLYSGILPFYSWNNAGDTGINMSAISGE
                     EGQKFPIKIPFIINPKSVNMRVVYDYPVSKGNHNLAMLKGRFIQPSEFADKIIQGFESA
                     YLGAMENTETLLRIIQQYGELEVRYLIRNTQQYAIVLSSSYHPELLVDGGARNLFFYSL
                     ANGNLQNQRSRSLIEYEIEDLLSGDIPYFYFRGSKKNIYTWDGREVKDFFSKPALQQIE
                     ENIQNLSYKNLEQQTQYIKITFNMENAGTRKIKNKRLKLDLYSNMAKTAEELAKELLDK
                     IGTNAIYSEDGADVNWIGVKLFGIKENQWMIQALPNTLYDGTVGINLVFHLYEWIYHDR
                     KYHKICEVLDNRLLRYIDTISEGEQNIEDFNTGIFSGEGSILYTLGILYEIYDDIKYKE
                     YFDKWLNCMETLILEDRLFDMISGNSGIVLVLINMYRKTKKPIYLQKAIQIAEQLIENM
                     ITENGKVGWKSEVVPEVLAGFAHGNSGFIELFSRLYEVYPQTKYLDILSSLVEYENSLY
                     SEKDNNWIDLRKFSEVDQHKSQPIAWCHGAAGILLSRLTLYNAIKNLGETALLQQAIKD
                     ISLAKNKLIEDGLHAGFCLCHGNMGNLLILKRYAEIFDDKQVRSICDSRFEQILEFLNE
                     ENILPTELYNPGFMTGLSGIAYALLKYKMPKLPLLIGVEGIYDRNEV"
     gene            25798..26340
                     /locus_tag="DW767_RS16360"
                     /old_locus_tag="DW767_16365"
     CDS             25798..26340
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223609.1"
                     /locus_tag="DW767_RS16360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16365"
                     /product="hypothetical protein"
                     /protein_id="WP_054338131.1"
                     /transl_table=11
                     /translation="MIEMKFSKNDEEDGLFRISSRDIVGFYNCSSKQERKITDIIKCYG
                     TTKSIKEVELKNMKPEDNVTVSRYIERNVGSIINKDYVIEGFLGMGKLSDCKDEMVSRL
                     DISKRYCLEILVAFLQEADIIILHEMFENVWNHTIEEILVEFSLRGAVVVFSEHGEESL
                     MKLPMHSYDLSGRCVGW"
     gene            26489..27256
                     /locus_tag="DW767_RS16365"
                     /old_locus_tag="DW767_16370"
     CDS             26489..27256
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223606.1"
                     /locus_tag="DW767_RS16365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16370"
                     /product="hypothetical protein"
                     /protein_id="WP_114002467.1"
                     /transl_table=11
                     /translation="MERVLIISYIISMILTAGFIYCIYREKYWVFEFVNRIKKPIQQLV
                     YVFLMLLSSYAYICFSLLIKADFNAVICAVLLLLLIWAMDYLFSLCFKKNDLGISEKKR
                     YIFMAYVGACISGFIIASRDASKMALEIPNITISVLIGAYVPFTLLLEDGKKGKVELQS
                     MKEEWEEKYKKTFRERKVKDILSALLFAMVYGVLLVGALSPAQNIINDIASGIGMGMAT
                     VVVAFVGLVEVKNRLTKRRNKREDADQEKSDTE"
     gene            27438..27767
                     /locus_tag="DW767_RS16370"
                     /old_locus_tag="DW767_16375"
     CDS             27438..27767
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009261866.1"
                     /locus_tag="DW767_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW767_16375"
                     /product="DUF1648 domain-containing protein"
                     /protein_id="WP_054338147.1"
                     /transl_table=11
                     /translation="MKLVGSRKLTWGICSIGVLLAIVSVFFLPQIIPVHFANGIADDFG
                     NKVEIFLFPILLIIITLLTGKENIKYFLTHSKTFLTDIQYNLMIDGVLGIVLIAEIYVI
                     YASFV"
ORIGIN
        1 aatttgtttg tttcagcaaa ttgatgaggc atttgagtat tacatttctt ctagaaatag
       61 aggacaacta tgggtatgga aattttataa tgatatgtta gaaggctttg tagcagatta
      121 tttgcctttt ttcccttgta aagcaggatt ggtttcgtta tttgtaacag tgaaaggaga
      181 gttatatcct tgtatagaaa ctgggaaaaa atatatgata ggaagtgtag acaaggggtt
      241 agatgcagag tatataagaa aaattattaa aatagagaaa acgcaaaata cgagatgttt
      301 acagtgtaaa gagtataaag aaaataaatg tagaatttgc agttgtttat ttggaaatta
      361 cgaaaataca ggaaattgtt atataccttc tgaaattaac tgtgaactta ctcgacatgt
      421 aaacaatata tttcgagaaa aatatagtga agaacaagta gcaatgcttc gaaagcatta
      481 taggagagag ttgtagtatg ggatataaat atagggtggt ggaaattgga gaatatgttc
      541 taattatcca aagagaaaaa aatatttgtt ttaaaatgaa gaaaaaagaa tttgaagaag
      601 agggtgacat aaagattcgg gaaattatag atggaatttc aaaaatgcga aagaaatatg
      661 atgtgacatt tcctgagaat aaaaaacaga tgaatacaat ttatctattt gttacggatt
      721 attgcaatct gaactgtgaa ttttgtgcta tgcgttctaa taataaggat atcaaaaaag
      781 agaaattgtc tcaacttgaa gtaaaagaac atgtaattga taaaattagg aaggctaacc
      841 ctagaaagtt aatagtcagt ggtggggaac cgtttgtcct agaggacata ctagatattc
      901 ttaaagagtt gaaggaaaat attaatacaa aaataattgt tcagacaaat gcgactctat
      961 taacagaaaa gactattaaa agccttaatg gaattattaa ttccatagaa attagtacag
     1021 cccattataa aaatactgag caattaaaag aaaagattgc tttattgaat aaatacaaaa
     1081 tagatgtagt gttaacattt acatatcaga atgaaaagga aaagatgttg cttcgagaaa
     1141 tcatagatat ggctgcatat tacgatgctg attttttgtt gcattttgta gattatgcag
     1201 ggagtgcagc agatagaggt tatccattat taaattatca agaaaggtta aaggtatact
     1261 gctattttgc taaatatatc atagaaaagg gctatacgaa taaacgtttt gccggaaatc
     1321 tttttcatgc ggtagaattg agccatccat gttcagcatt tggaaaaatg gctgcttttt
     1381 tccctgatgg aaatatatat ttgtgtcatt ctctggttaa agaaaaatat cgaataggca
     1441 gtatagaaca agagacggat atagagcaat cgatcgaaaa aatattgtct aatgacaatg
     1501 tggaaaagtt attttatatg cctaatgaaa aatgtaagac ttgcaaattt aattgtgttt
     1561 gtggaggaat gtgtccagca cttatagaag aaggagtaga ttctgactgc acattaagaa
     1621 aaattatgtt tatatatagc atgtttatat ttgataaaaa tgaaaatata gcaataaatt
     1681 tggaaagatt tataaaattt tgtgaagagg aagagtatca gcaatttttg tgatatgtat
     1741 ataattagtg aaaactattt atataaattt ttaatgaaag gaggagtcaa aatgctggaa
     1801 cataaagaga ataaggaatt aacagaggca gaagttaatg cgtatgatct cgtcattatt
     1861 tgctacggta aactgagaaa agattgctta actgattgct tagacggtac ttattggtta
     1921 tcaccagagc agtaagatgt gctaggaaaa acccattttc aaaatcagaa tttggttttg
     1981 aaaatgggat ttttcgtaaa tttatataga attgaggtag gaaaaatgaa aggcaataat
     2041 gaaaaaaagg taatagggca tttagcaaga caggatttga atagtgtgag gttaaagaag
     2101 ttttgtggca ttttaacgat aatattgtca acagcattaa ttatagtggt aacactttat
     2161 tttgtacaaa cacaacgttt ttcaattcaa gatgctgaag gtcggtatca agcgacattt
     2221 atggatgtta attctaaggt tgtcaataaa atgaaagcca tgaagaatgt tgaaatggga
     2281 gaaactagaa cactggggac attaaaccag gggacttata aaattactat aagaacaatg
     2341 acagagtcgt tactaaagtt aggaagatat cccgaattaa aggggaaatt acctgaaatg
     2401 gaaaaagaag ttgtagtaac tgattcatat ttagaagagg ttcaatcaaa ggccaaaata
     2461 ggtgattcta tagagataga tttaggagat ggaaaagaaa gctatgttat tgcaggaatt
     2521 ttacctatgc agagtactgc agatacacat tcgatatatg tatctgataa attgattgaa
     2581 agaaaaatgc caggggcttt atatagcata tattttaaaa ttaacgatac tcaaggctgg
     2641 aacgaagccg gaataaagag tgaaattgat aaaatagcac aacaattaga tgtaccaaag
     2701 gatagcattg tttattcatc ttattatttt tctcttatta gtcagaaaag tattcaatat
     2761 ataagtgtta ttttgggcgt gagtttagtc attgcaatta tatcaagtat agttatttat
     2821 agtatatttt ttgtttctgt tttggagaga attggaaaat atggacagat gagaacattg
     2881 ggtatgacta aaaagcaaat cagaaaaata ataaaaatag aagggaatgt tttaactcta
     2941 aaaggttgtt tttggggatg tgtttttggg ggtattatag cttactttat tcaaccaaaa
     3001 ggatggtatt tagtgaatac tattttaata tcaggtatgg cgagtgcgtt tgtttatttt
     3061 gttgtaatgt tatctcttta taaaccagca aaaatagcat ctgcagcctc tccaatagaa
     3121 gcattacgat attttgcaga tacagaggta aatataaata ggaaacattc atataaaaaa
     3181 attacattgt ggagattagc attgttaagt gtgcagcgta ataagaaaaa aacgttttta
     3241 acaatacttt ctttaggaat ttgtggaata gttcttatgg ctagctcttc ctacttaaat
     3301 tctattgatc catataatat ggcaaaaaaa tcaatgccaa atggtgaaat aaaaattgaa
     3361 cttggaacat acggaccaca gtcttatacg agtaaacaat attttgattt acaaaaaaat
     3421 aatattttaa atcaagagtt gctaaaaaaa ttagaggata tgcaagctgt cgaatcaatt
     3481 aaacagtata aaggaacagt ttgtgacata acattaccga atggcgatac agatattttt
     3541 gttgtggacg gaatacaatc gggggatatt actaatttaa agaaattttt agtagatggt
     3601 gaaatagatt ttaagaaaat gcaacagaaa aatggaattg tagtttcgga agcaagtgag
     3661 tgggaaactt tatgggattg ggaagttaaa attggtgata caattaatat tttagatagc
     3721 gagggtgtac cagtaaaata tgaggttgta ggaattgtag aaaatggtgc tgattatggc
     3781 ggctacaata tggtgtatat gcctttatct aatatggaag aattaagaaa agatgtatta
     3841 aatttaactt atcaattgag tataaaaaca acaagtgata caaatgtttc aaaaacagaa
     3901 gatatgatta gaaagatgtt tcaaaatgaa atgcctatcc aatttactac catagatgat
     3961 gttgctgctt catataaaca aaggatagat gcatatagaa agccagttta tggtttagtt
     4021 atatttgtag gaatttttgg tattgttaat ttgctaaata tgctgttttc aaatatggca
     4081 acacgtaaac gagaatatgg aatgctacaa tgtgtaggtc taactgataa acaattatca
     4141 tctatagtag taaaagaggg aatcttatat tccgttggtt cgatttcaat ttctttgatt
     4201 tttggaacta tttttgggat tatactgtgt aatgtattta gttcctttag tgtttttgga
     4261 aaagtgatat atcacttccc atttaaagaa atgacggtat atttttcaat acttattatt
     4321 gttcaaatga tatttgccta tataattatt aatttttaca agagagagag tctgatagat
     4381 agaataaaat agagtatatc tactaataaa agaattttat aaattaatat atgggcattg
     4441 tatttgttct tttgcttcat aaactgcaat atatttttgg tttgaaaatt gagtatgagg
     4501 gtgagaaaag ataacagaaa aggtaggaaa gcgttcagtt gatttcctac ctttcacatt
     4561 atggactgtt aaatactctg tttaataata cgagtgataa tccccactgc aacattccgt
     4621 tcttcatcaa tatgtgtcac aacaaaggac accttatctt tcttcccaac ggtgcggctg
     4681 tcgtagcaac tgtgagcaat ggcgttgacg cccaattcta accggacaaa aacagttcct
     4741 ttgtggatgt cttccaccgt tccggcatat tttccctgta cccgacaact tttcagattt
     4801 tctttgctgg tgttgccttc cacgattttt acatctgcat ggatggagag cgtttctggg
     4861 gaatctcccg ggatagttaa gattcggacc agaatatgtt cccctacctg gaatcgttgt
     4921 cagattattc tagtatgggt gaattttttt taattgtaga ggtttgtcaa gttgagatga
     4981 agaaataaaa atttgatata taaagagtta gccaaaatgg ttcgatatat gaattacaag
     5041 aatattgtaa gatacaaacg gttaatatag tgataaaata attaccaata taattgttgc
     5101 aatcaatttg aagagatata catattactg gaggcttgag atgagaaaag atattataat
     5161 tattgatgat gatagggatt tatgtacact cttgcaagag agtcttttgc aagaaaatat
     5221 ttgtgcagat atttcatgca acggttttga tgggataaaa tcagtaaaag ataaggaata
     5281 tcaattagtt gtattggatg tgatgatgcc aggaatcagt ggttttgaag ttttagaaag
     5341 aatacgagac atgagtaatg taccaatact aatgcttaca gcgaaagatg acagcacctc
     5401 aaaagtaaaa gggttgcggg cgggagctga tgattatttg acaaaacctt ttgaaatgga
     5461 agagtttttt gcaagagtat tatctctaat aagacgttac acacgtttaa ataatatggc
     5521 tagtaaagca attttgaaat atggcgattt aagaattgac ttagaaagtg gcatagtaga
     5581 attgtctggt gaagagctta aattatctgc aaaagaatat gatgtactta tatatcttgc
     5641 aaaaaatcaa ggaaaaattc tcacgaagaa acaaatatac gaaaatgttt ggaacgaaga
     5701 gtatgtatat gatgatgata acataatggc agttattagc agattgagaa agaaaataga
     5761 gcgaacagca gaaaattcgt atattcagac tgtaagaggt cttggatata gattcaataa
     5821 ggagttatga gataaatgaa attattttat gtggtgctag tcatactttt attttataat
     5881 ttgggattga cactttatgt gtttaaaatt aatagaagac taaaagagtt caatcaaata
     5941 cttttagaaa tagagaaagg tcaaagcaaa caaaagtttc tattgaaaaa aaataatagg
     6001 atagatcaag ttggatttag agtaaattct atattgtata aatatgaaaa aaggatcgaa
     6061 gagagtaaca tagagttgga agcaaataag caactcatga caagtttatc acatgatgtc
     6121 agaacaccca tgacaacctt aatagggtat ttggacgctc tagatttaaa actggtaagt
     6181 tcagataaag aggaacaata tctaagacta gcgaaagaaa aggcgtatga cttaaaaaaa
     6241 tatatcgaag tgttattcga gtggtttagg attaattcag atgaggaaca gttggaaata
     6301 aaagcagttg acattactga agaaaccaga aggatttttt tggattggat ccctataata
     6361 gaagaacatc gaataggata taatatagaa attcctgaga aagctataat tgttgagatt
     6421 gatgaggatt gttatatgag ggctataaat aatattgtgc agaatatttt tactcatagc
     6481 aaagcagcaa acatatcaat aacagcatca gaggggaatg gtaaatttag actcgagata
     6541 ggtgatgatg ggatagggat agcaaaggaa gatttgaatt atatttttga aagattatac
     6601 cggtgtaata aaggaagatc cggaaaaggg aatggactgg gattaaatat ttcaaaatta
     6661 ttgctagaga aaatgggtgg gacaattagt gcatttagtg aaccgggtaa aggaacagta
     6721 ttttgtattg aattttcagt tatacaaagg taacaaaaaa gatgatacgt tcgagtatca
     6781 tctttttcgt attaaataaa ttacaaggtt cttgtcaggt ttctgtcagg ttcctgtcag
     6841 aaaaatatat tatactgtaa aacatagaag attctgaaag gagaaaaacc aaatgtcaca
     6901 atacattata caaacacgtg atttaactaa aacatatgga gaacagaaaa gtgtttccaa
     6961 tctaaatatg catgtaagaa agggaaagat atatggactt ttagggagaa atggagctgg
     7021 aaaaaccaca actatgaaaa tgctgctaaa cctcatagaa ccgacatcag gttccatacg
     7081 tatttttaat agagatataa ggcttgaaga gaaaaaaata ttacctcgaa taggatcact
     7141 gattgaaagt cctggatttt accctaattt gacaggtacg gaaaatctta gaatttttgc
     7201 gaaattgaga ggaatcccaa gaactgatgc tatcgaacag gcattaaaac ttgttaattt
     7261 accatataaa gataaaaagt tatattcgca gtattcatta ggaatgaaac agcgattagc
     7321 tatagcatta gcggtaatgc atgatccaga aatattaatt ttggatgaac caattaatgg
     7381 cttagatccg ataggaatcg cagaaataag aacatttata gaagatttat ctaaaaatag
     7441 agggaaaact atattgatct ctagccatat actttcagaa attgctgttt tagcagacga
     7501 tattggtatc attgataaag gcgtactcat tgaagaggga agtatgaagg aattagaaga
     7561 aaaaaatgga aaatatatac acttcaaggt ttctgataat gcccaagcag caagaatact
     7621 gtcagtgtat tataaagaat caaattttaa ggtatcagga aaccaagata taaatgtgta
     7681 taatctcagt atatcaatac cagatatagt tcgttccttt gttcaagaag gagtagacgt
     7741 gatggacgct catttgtgtg aagatacttt agaggactat tttaaaaaag tgacaggagg
     7801 ggaaggaatt gcttgattta gtcagatgtg agtttacaaa attgaaaaga aggaaaatca
     7861 cgctcatgct gattgtatta tcatgttttt tccccttaat tgtggttatg acaactaaga
     7921 acgggatgtc tggtgatctg agcacacatt atttgaaaat gaggtttgat ttatccttta
     7981 ctatgacaca gggctatggt cttgtattcc ttgcaccttg tttaatagga atgcttgcga
     8041 caatcttgtt ctttatggaa cgagataatg atacatttaa aaatattaga acagtgcccg
     8101 tgacaattac caaaatgatc cttgcaaaga tctgtgtact ttttatatat ggtactcttt
     8161 ttagcctggc gagtgtatca tttacaatat tcttttcatg gatattgaag gttggtatta
     8221 tatatgattt agcatacaag ctaggattta gtattatatt tgggcttgtg ataacgatag
     8281 cgtcacttcc tattgtggtt ataatagtat attttaataa atcctattta gtgtctacat
     8341 tgttggcatt tttttattcg attctaaatt ggggaattat cggtttattt gaaacaatgg
     8401 cagtgaaagg taccgcaaaa tttctaaatc tatttccagt tatatgtgcg atggactgga
     8461 caagcggtaa actggtagat catgtaataa aagataattt gtcaaaagaa gcatatatta
     8521 tgtttccgtc agatatttat gcatttttgg tattaggagt aacattgttc ttatctttaa
     8581 tgcttatgat tagattttat aaaaaatgga cgaggtaatt taaatgggaa atattatatc
     8641 aacagagtta ttaaaaatta aaagatattc agttgtaaaa gctggattag ttatgatgtc
     8701 gctatctgtg ttaatgagtt gcttttattc aattgcaagc acaaataaag tatgggattt
     8761 tcagtatttt atacagcagg taattattag taattgtaca ttatttttcc cgattattat
     8821 tacattagtc gctgtgtaca ttatttccag ggaaacaaca gatgatacat taaaatctat
     8881 tttaacagta cctatttcat ataaaaagtt acttattgct aaattttggc tgcttttatt
     8941 tttaactata gtttttagta tttttaacgc tcttttgtca atatgtttta atgctttttt
     9001 aggattttct ggaatgaata ttcatatgat gctgatgtca gccgctcaga ttattgtatc
     9061 tgacatattg gtgtatatat cagtacttcc cattattatt gtttgtgctt ttgcagaagg
     9121 aaaatcattg ctgggagttg ccgttgcatt catctacgga tattttgcaa caatggaagg
     9181 aagtatgctt aattggtttc caatcaaggc tgcaatgata cttgttgatc ctaaatgcgg
     9241 aagcgaatat ggaataacat ataaaattcc tcctgcggcg atgtctataa ttggggtttt
     9301 ggtggtttcc atactattgt ttcaaatgct aaacagaacc aaaaagaatg tttatatgaa
     9361 atcaaaaaga aaagtaaagg taaaacaaac aagacggaaa gggtggtaaa aaatggtgga
     9421 ttgaatgtaa agaaatgttg tccgtaatca taaacaattt taatatatgt ttgtaaggaa
     9481 ggagaagaga aaatacatac tgctagtcaa gtgaacttaa cagaaccttt taaggaaatg
     9541 agaaatgaaa aaataaatat cttaggatga acctgaaggg ttctgtattc ctgcagtatt
     9601 ttgtgaaaaa ttaaatcgta tagatataga cattttgaat ttacatatgg tatctatgca
     9661 agaagcagtt aggagcgtgc cttatgaaga aaaattatag aaatccaatg acaagaccag
     9721 aaaatttcat gaatccggca ggaaatgtaa tgaaggaaat taaagaggcg gatttaaaca
     9781 atttttccgc aggtgctggt gaaccaagag tttccgatgg gtctcagttc tgtacatcaa
     9841 caaaagaatg taactgggga acaattatgt ttgtttgctg ttagtttatg agagtggtat
     9901 gaaaccacag gtatgatgac tactgaatga ataggtttgg cttctatgca tagatatcat
     9961 atgcaaattc aaaatttttt acataatgga ggagattatt atggataaaa ataattgtga
    10021 caataattcc tatttttatg aaagaaatta ttataaggat gttccaatca aagatactca
    10081 aatattagaa tattggaata acattttagg taaagatgtt attgaatcaa tagataaggc
    10141 ttatggggtt tctatagagc agatattatt ttcagagtat tcgttaaatc ataaatatat
    10201 tagctttgca acgttaaatc aggaatattc tgatatgtgt aatgagaagg ctatatccta
    10261 tttgactaaa aaagggacaa aagtattatt tgatcaattt gttctcaggt ttctgggata
    10321 tgggaaacgg gttttagaaa gaaagagtag aaaaggatat attgttaaag taattcagga
    10381 ctgttttttg aaaaatttag cggaaaggat tttagatgtt tctttaagca ctcttatttt
    10441 tgaaatgtat ttagcaaaag aacaaggaga acttagagga aatgatgaag cagaagaata
    10501 taacgactat aatcagagat ttcttggtaa tgataagtat ataaaagaat tattttccat
    10561 atatccaggt cttaaaagaa tgctgataga attaatggaa aatttggcaa ataattatat
    10621 attattgcag gaaagaatgg aaaaggatac tttactttta gaagataaat ttggtgggaa
    10681 aaagagctgg actgaagtaa aagatataag aacgagtggt tcagattcac ataagaaagg
    10741 aaatagtgtt tttttaattc agtttcaaga tggaacaaaa atagtttata aaccacacgg
    10801 actgaaggtg gagaaagcat atcagtcatt tttggaattt atttcttcca attgtaaaaa
    10861 ggactttagg caatttttga ttctggattg tggggactat ggatgggaag aatttgtagt
    10921 taatcttcct tgtaacagtg aggctgaagt caggaattat tattatcgga taggagtgct
    10981 tgttttttgc aattatatat taaatgtcaa tgatatacat actgaaaatc ttattgctaa
    11041 tgggggatat ccggttgttg tagatgccga gactgtctta gataataaaa gggacaaaaa
    11101 gaaaaaatca ggtagagaaa aaatttacga taagatacat gaatcagtgt tgtattctgg
    11161 agtactgcct ttttataaat acactaaaaa tggaaaaggt ataaatatga gtgctcttaa
    11221 tggccaagag ggagagcaat atccaatact gattccaaga ttaaaaaatg ctgggacatc
    11281 aaatatgcat tatgaatatg aaagacctat tactcaagct agtaataatt tactgagact
    11341 gggggaaaag gtaaaagaac ctaatcagta tatagatgag atatgcgaag gtttttttga
    11401 cgcatataca ttttgtttgg acaataagaa gcttatatta aactatgttt cgatatttga
    11461 aaatattgaa gttaggcatt tagtccaaga tactcagcgg tattccatgc tattgcacac
    11521 atcatacaat ccggattttc ttcaagatgc gaaagatagg caactatttt tgtgtgcagt
    11581 gttaaaaaat gtggaacaga tgcaagggaa tatggaaatt gcaaaactgg aaataaagga
    11641 tatgctgaat atggatattc catattttta tagcaatact tcaaaagaag atctttatgg
    11701 atcagaaggg gaagtggtga agaactattt tgctgagtct agtattcaac atcttagaaa
    11761 taagatctgt tctatgggca agaaagatag agaagaacag attagattta taaaaataat
    11821 tttaacagat ttgaatgatg taaaagttga gaaacctaaa aaagatataa atgaactttg
    11881 tataagtaga agcgataatg aacatggaca aaaggaatat aaaaaaaatg ccatattaaa
    11941 aattttacat acattagagc aaaaagcttt ttatggtgat gatgggcagg atataaattg
    12001 gataggaata acatctattg gaaattctga aaattcttct tggaatatcc aaccattagg
    12061 ggtttattta tatgaaggat taggaggaat tgcccttttt tataatgcac tacagcaatc
    12121 agattttgat gtggatttgt cagcagcctg caaagcattt gagaccatga tgtttcaata
    12181 taccgatgat atgttggaac gatccacgga tttagaaaag gaaagtagcg gtgcttatgc
    12241 gggggaagct tctgttatat atgtatacga agttttatat aagataacag gaaaacaaaa
    12301 atatttagaa tatgcagaaa aacattgcaa aattttagag tatgcattga aagcagatga
    12361 aaataatgat ctgatttatg gtaatgcagg tgccgttatt gttcttctta atctttatca
    12421 cttagctcaa aaggatatat atttgcaatt ggcgtgcgaa gcagggaaca ttcttataaa
    12481 aaatcagaat aagggtaagt ggtgctgcgg aaacgggcag agcttatctg ggctgtcaca
    12541 tggaattaca ggtataattt atgctcttac aaagttaaat aatgagcaat ttcatattga
    12601 atatcaaaag gcaatacact ctggattaat atatgaaaat accatgtatt ctgataaata
    12661 taataattgg ttagacaatc gggaggaggc aaaaaaagaa gaaaactctg ataatagatg
    12721 catggcagca tggtgtcatg gggcaccagg gattttattg gcaagaagta agatgtataa
    12781 cctggttaaa gacagtagtg attatataac agtacaatgt gatattgaac gtgcactatt
    12841 tgcgacaaaa atgtatggat ttacagataa tgactgtcta tgtcatggga atttggggaa
    12901 tacagaaata ttacttgaat attcaaaaga atgtaatgat gaagaagtaa gacatatgat
    12961 gttgtctgcg agaacacaaa ttgctatgga tattataaat gaaaattacg attgtgcaag
    13021 gtcttatttg catgggtata agataccagg atttatgaca ggaatctcag gaatgggata
    13081 ctctctatta agagatttgt acccagaatt accatgcatt ttggctctgg agatttagga
    13141 gcgtaattgc taagtaatat ttaacaaagg gaggaacttg atgtttcaaa aaaaagtgca
    13201 ttatgtttca cagctaggaa gcatggattg tggcatagca tgtctgacaa tgattcttaa
    13261 ttattacggg tgtaaaagtg atatcgtgga cataggggca gagattcaga ttggcagaga
    13321 cggtatgacc ttagctcaaa tgaaagaatt agcagaaaag tatggattta aatttgctgc
    13381 ataccagtat aatcatgaag aaaaaaactt aatagagtat cttccagcca ttttgtgtaa
    13441 tgattcccac tatgtggtag ttgataaaac taagaagaaa ggaaaatata ttctgtttga
    13501 tccagcaaat ggaaaaagag ttgtcgattt tttagaatta aaaaacggat acaaggatat
    13561 tcttgtatcc gttattccaa gtagaaatat taagaaaata aaaaaaacca aatttaaaat
    13621 agaggtaaaa ttctctcaat ttatgattgc aattatgttg atgcttatgt gtcaacttat
    13681 tacattagct gttccaatgg ttgtgcaaaa agtaatagat agtttatctt ctgcccatat
    13741 tacaattcat atatggaaaa ttacactttt agttcttctg attatgtgtg cccattttgt
    13801 attgagctta ctaagacaga aaattttatt gaatattaac atgaaacttt ttaaaacaat
    13861 gatttctaat atgattcata aaattttccg tttggatgta agtttttttg aatggcattc
    13921 cgcaggtgac atagggaacc gtttcaatag tataaatcag ttgaacgaca ttcttaccaa
    13981 tggatttata aacattataa tccaagggat tacatccttg gtatgtttag ctgttatgac
    14041 cagtatatct ccatatttga ctgcatttgt tctagttgtt tctattatac agatcgccat
    14101 aatgatttta ttaaatggta aaaatctcat aaagacgaaa gagtatatat actcacagag
    14161 tacaatacag ggagaactga tagatactct ggagaatata atggaaataa aatgtatggg
    14221 gatggataat gcagttaaat caaatttaca aaattcttat agtaagttaa tagaaagatt
    14281 caagggaaaa actcgaatta gtaatttgat gaatagtttt tcctcaacct taaacttgat
    14341 tttcccttta atgatttacg tgattggaag ttatagtgtg aagcaaggag ggttaacgat
    14401 aggacaactt atagcctatg caaccttagt gggatatttt acagcacctt ttactaccgt
    14461 tgtattgttg ttaccgagta tcaatagtat taaagaagtg cttttacgtt ataaggaact
    14521 aatgattttt agagaaaatt atcatacggg agttcttgta cctggaaaat ttgaaaattt
    14581 aaaaataagt tcggtttcat attgctacaa tagtgggcag gcatacgcat tgaataatgt
    14641 ttctcttgat cttaggcgag gcgagagaat tgctattgtt ggtttatcgg gtagtggaaa
    14701 atcaaccttg ataaaagcca tactgggtgc cgtggatatt aatcaaggat gtattgagat
    14761 aaataattat gatatcagat caatgtcgaa ggaacagatt tataaatggt tttcagtagt
    14821 tactcaaaat cctatgtgct taaatgcaag tataagaaag aatattgata ttataggtga
    14881 tgctccggat gagaaaatat ggaaggtact agacattgta gcattaaaag aggaagtttt
    14941 aagtatgccg ttgggattgg atacacttgt tggagaagga ggacaaaata tttcaggtgg
    15001 tcaaaaacag cgtattgcca tagcaagagc tctgcttagc gatacggagg tagttatttt
    15061 tgatgaagct accagtaatc tggatcagct tacagaaaag aaaatttatg ataacctaag
    15121 gtctaccaat aaaacgcaaa ttatcattac tcatagactt tcctctattc gagatacgga
    15181 ttatatctat gtattgaaca ggggaagcat cattgaacag ggaacacatt tggatttgat
    15241 gaagaaaaag ggatggtatt ttgagagtat tcaatgacag ataggaatta aattatgata
    15301 tgaaaagcca ttgtatgggg aggtattaca gatgaagaag aaagagatag ttattggggt
    15361 gagcgtactg attagtgcat cacttcccat ttcagtttat gctgcttcaa atgaaagtat
    15421 gagttctaga ggttttataa ttgatgaaac taatgagttt gaggatatcg ttaagcaaat
    15481 tttagatgtt aagtcaaaac atccggaatg gagtgaacag cagataagtg attttatgga
    15541 tcagattcat gctattaaga aagatggcgt catagacatt tggaacgcac ttacttcttc
    15601 tgagaaaaaa ttagtgattc gatatccgtt tgatgcacta aaagtcaata aagcaaagga
    15661 aattgccact aaacaaaccg aaagaaaatt cggaaaaaat ggtttgggtg acaggagtga
    15721 cgcatttaga cacggaatat ggaatgccga aatgacagtt ttgataggaa gtgaaaaagc
    15781 agagcttttt gcgacagcac atgaagataa agatactact ggaaacgaaa gcgatggata
    15841 tacaaaagat gagcacaaaa aaatggattt acataacaat gaaataggga ggaaattagg
    15901 tgcagataac ctatctgcac cagaagagaa aatggcggaa atcatatatg acgagataat
    15961 gagagaagat tcgctgtttg tatggctgca tgaatgaaaa agttagaacg tatgaactga
    16021 aatgaaatat atctctaaga cagtcgcaga tattttattg atgtttagat atctgtgact
    16081 gtttttgaat agaaataata gtcgttaaaa atgtctgctc tgactaaatt tgaaagaaga
    16141 atcagaatga gaaccaagta ctaatgtata gccatgaatt agatgtgaaa tctgttaaat
    16201 gatggtcaaa tgagaatgag ggggctgtag aaaaatattt atcaacatat tatttgtcga
    16261 tttagtttaa gtaatgacaa taacaataat aaagggggac ttgatttctc atatccccca
    16321 gtgtataatc taattaagaa aggtaatcag atgcaagatc tgatgccctc agtaaaattt
    16381 aatttttttc tatgttaaga catagcatcc atcaaacttt ctcagggttt atcgtggatg
    16441 ctatttctta tcatgtcgat tatctatgta agtcagagcc gcaaaaacta ctaaaagcaa
    16501 tgtgagtact tccattgtgt tcatgggcat caccctcctt taaaaactag agggctggtc
    16561 gaaattgcat ccgcatctct ttctcgatta gctatactcg ctcagtatag catggaatat
    16621 cttgtatcgc aataagaaat ggatgtagtg agctcctttt catattgctt ttggtaatca
    16681 gatattttgt ttgataatcc ttgtaatgat gccaacagca acattccgtt cttcatcaat
    16741 atgtgtcaca acaaaggaca ccttatcttt cttcccaacg gtgcggctgt cgtagcaact
    16801 gtgagcaatg gcgttgacac ccaattctaa ccggacaaaa acagttcctt tgtggatgtc
    16861 ttccaccgta ccggcatatt ttccttgtac ccgacaattt ttcagatttt ctttgctggt
    16921 gttgccttcc acgcttttta catctgcatg gatagagagc gtttccgggg aatctccctg
    16981 gatagctaag atccggacca gaatatgttc ccctacctgg aatcgttccc tggcatcacc
    17041 cagccagtca aaagacagat ctcttgcaag gatggaagtt tctacaccaa agatttctgc
    17101 ccggactact ttttcagcaa cggcaatgac tctggcctgc acaatacggt cttcgtggat
    17161 tttattctgt ccggaagagt cctgatcaaa atagaaaatc tgacgtttct tcagcatagc
    17221 atctttccgg ctggcaacga tgcttctgga tttggtatcc agtcctttga ttacaaagtc
    17281 gatttcacta ccaagcatgt tattaaggac tttgttctgt ctaagagaga aatctccgta
    17341 atcatgagtt tcatcttgga tcagattgat catcatttcc gagataggga tgactgcccg
    17401 ataatcttta tagtaaataa ttgctattaa gctgccggct tcggtctttt caatacctcc
    17461 cagaatgccg gtgagaattt tccgggtacg ataggcattt tggatgtcat gccagattaa
    17521 atccgctttt gattgagcag tttctaatac agtatcggag tcaagggtta aaataggggt
    17581 gttcaggttc attgtttcgt ttgccataaa tgttatctcc tttcaaaatg tgttatgaca
    17641 tgatggaatc tttatctaaa ggaaccatgc cagagtcggg ggaatcttct ataaaatttt
    17701 cctgaaagaa atcctccata aaatcatcgg gagtaggttc ctgataaacg ggttcggatg
    17761 taaaatgtgg tttctgtttt gctattgacg cagaagatga acggcgtttc cttttggctg
    17821 atccgggtga gggctgtggt cgatactctg tttcttccga agacccattt ttgcgccatt
    17881 caggtatgtg ttccgatgct tttcttggtg tcagcttttt ggcatctgga tgcagggtat
    17941 aatcgtactt ttctactttt aggacttttt gcccacgtag gataaccaaa gcagtatcaa
    18001 gcgggagccg caagatttca tctggtgtta agagttttcg tttgccgata gattttgtct
    18061 gccggtattc cggtgtatag tcggataccc gccagctatt gagctgcttg gcttcgctgc
    18121 ttacccctac ggtcacatcg ccgctgcggt tgctgataaa ggtagcagta acttcatctg
    18181 tgcagcccaa aaagagctgg gtatcacagt tgccaatgat ttcctgccat tggttataag
    18241 gatagcggtt ctgcatctgg ggcaaattct gaaagatgca ggaaatgctg agattccggc
    18301 ttcggattac actgattttc ttattcagtt ccaggatagc tccggtgttg gcaagctcat
    18361 cagccagtat atgtacagca acaggaagtt ttccttcttc tccatactta tctgcataac
    18421 ggaccagttt gatgaagatg aaggtcataa acagggaaga taaaaaatcg aaggtgctgt
    18481 cctggtctga ggtaatgcaa aagtaagcac atttctgttt ccctggaagt gtcagatcaa
    18541 tctcatcata agaggtaatc tgccgaatga gtttattctg aaatacctga agtctggcac
    18601 ccaatccgat aataactccg cttcgcacgg tatcactggc ttgtttgtag atgcagtaag
    18661 gaacttttgc tggatgggac actgggagca gatcaaaaag actgttcagc tccttttcgg
    18721 aactcatggt cagcagctta taaacctgtc caatatttct ggcttccggc ggaaagccct
    18781 gatctacata gagaaccagg gcttttagca ggttcatctc cgcattatcc cagaaatgat
    18841 ctccttttcc ggaacctgta ttctggataa tgacatctgc aaatacctga gccatcgttt
    18901 cttgtccatt gatttcaccc agacaattcc aactatccga gttttccgga ttgaccagat
    18961 taaatgcttt tactacatag ccctcatttt ccagataagc agacatgctt tcatagagtt
    19021 cgcttttggg atcggtaatg attaaacttt ccccggaagc gttgttgcct tcctgccctc
    19081 tggcgacaca ctggaaaatc atattcctgg caaatgccct ggatttcatg gaaccgctgg
    19141 caccatacac ggcgatattt ttattcattc gtgtttgata tggaagacat acggctttgc
    19201 catttaattt tcctaaaatg gttcctttat ttttcttgac atctccggtc agttccaaaa
    19261 ctttcatcat ttcatctgga gtcatgaatc cggatgtacc gtaggttcct tttgtagagt
    19321 aatttaagtt ccggtcatgg tcactaattt ccccgtttct gtcatatccc atacgcataa
    19381 gtaaaaaagt aagaagccca aagagaacca ggcaaagaaa aatcccatac aaattgtatg
    19441 ggaaatcggt aagggcggta tgaaagcaga ccaatgggtg taaagaagct gcttgcggat
    19501 aggttccgtt gccggcaaag tttccggcag aagtccattc ctgatagttt ttaataaatt
    19561 gtgctgcgta tcctccggca tacagagtgc agacgcttat gggaagcaaa aacaggaact
    19621 tccaccattt acggttcatt gaaaaacctc cttttaaact tttgaaaatc aatgctggag
    19681 aagtgtatat ctgcagttag gtattttttc aggcagggaa gctgaaagtc aaagcaaatc
    19741 aggttcccgg atagcccata tacatttaat ccagtattga agcggttgat acgctgcatg
    19801 tcaaaatcat acgcaagcaa aataggattt tcctggctgt ctattccatc atgttcaatt
    19861 ggcagatcct cacgctgggg aaaacagtcg gacagtagta gctgattgag ctgcatcata
    19921 cgctggggtt gtaccaataa acggagcagg tattctccgt agctgttatt gggcaggaaa
    19981 tagaagtgtt catacgaagt atccagcatg aacagtgttt ttttgtatcc accggtactg
    20041 gtaaggagcc ggaaagccat atccatatca ctgccagtca tgatggcata aacggtaggt
    20101 ggcccatggt aaggaagtcc ctgaagatag tgctgcaaaa aagcattgag tcggacttcc
    20161 gttttgtatt cccattttag aagtgtattt ccggtattat aaacagcata gacacagtga
    20221 ggagccatca ggattcctat acaacgggaa tttttaattt tggtagtgga tgctccaaga
    20281 ttttttattt ctctggaaga gtaaaacaga ggaaggcttc gcacaggaaa cgtagccgct
    20341 tcgctggatt cagaaaaaag cagcggcttt tcatctggaa agaatgggat tccggcatgt
    20401 gaaagcgtta aataggtttc tgctttttga tgaagtcgca gccgtcttgg taattcacta
    20461 cgtatgaggt tggtttctgc atttccggtt aaatagtttt gaaaacgaca gggattttgc
    20521 gaaagcagca gttcttttgc ccgtttggta aggcgataac ctcgtaggcc atctttatag
    20581 tgtgttctta taagcttact ctgctttaaa tctgtaacca ccttctctgc ataggaatca
    20641 ctctcaatca atctgttaag ctgtccggaa gggaattccc cacatagccc aaccatttcc
    20701 aaaagctgat attttataga atcggttttt atcaaataag catcacctca gttcgatttt
    20761 tacctatgac agcctatact tgggtaaagt aagggcggta ttaagcataa aaaatgcaaa
    20821 gaatatggct tctttgcaga aaaattaccc atatcggaaa aagaaagaaa aatatcagga
    20881 aatttccgat atggttttga tagactcttt tctatctttc agccagccag gaaagatttc
    20941 cggttccatt acaaagataa cggtgtgatc gtaattcccc agttccgtag tgtgatagga
    21001 gtcgcaaaag agtcccgtat catcaaccag aacataggaa gcgatagtat ctaaaatctg
    21061 tttgaactcc aaattatcgt aatcacgtat ccgttgtaaa gaaaggctct ggtcataaat
    21121 ttgactaaaa cagaccacac atcttttata taacggaata gaatgttctg tcacataagt
    21181 ctgcaaggca aggtttaatg gctcatgtag aaaagcggtg ttggttcgca atttacgttt
    21241 gggcagtagt cctggcatgg taatggaaag aacactattt gaaaaagaga ttttgattcc
    21301 ctgcacagcc gcagcctgtt tcagatagtc tttctttcca gtgtcagttg tggtatatac
    21361 cagatttctg agctggcagg caatcctttc agaacgtagg gcagcactga tactcagctc
    21421 ttcgtatttg tcggcatacg cttgaatatc tgttgttttc aatgcaaaaa tagtgttgtg
    21481 aagtttttgg acttcatcat caatgctctg taaacggtca aaaacagttt tggtgttcat
    21541 acatacctca tttctttgca taatagctga cagatccggt agaggagtct acaaggcaaa
    21601 aggcaatcac gcctgtgata tgaatttttg cagcctgttc ttctgtttct aatacaacca
    21661 gccgtttcgc atcgcttttt gtctggcttt ccatgacatg attgataaga tattcttgtt
    21721 cctgggggac atagaggact tcataccact catctttaga gaaaaagttc agtttcacag
    21781 gaaattcacc gtcagtatgg tacacaatgg ctgttttgaa gtccaaaagc acccaaaagg
    21841 atgcaatcat gccataatca ggattgtttg cagattcctg gctgtcgaag agaagcccgt
    21901 tctccttatc atagataatg cgtttttgtt ttaccagact tgtgatcaga gatttgatag
    21961 actctctgtt tttggaaaag agccgtaaga cctgttcata ttgcaacgaa tggtaagttg
    22021 taatgaaccg gagcagttgg gcaccttccc cttgatagat ttcatttctt gttttcatgg
    22081 taatctccct tcattatata ataggaagtt ttacttacac tgtacgcaca gaatacgttt
    22141 tattttaggg gaagtacgct gtacgtactg tgtaagtatt ggctactgtc agcgaaaggt
    22201 ttacgggtac aaaaaaagca ccgattaagg tgctggggaa aataggaata ctataagcaa
    22261 tacctattgt aacatgggta aaattaccct tcaatcgcag aagtgtgcca agttgtggca
    22321 tatttaggaa atgataaaga cagttgaaaa ccaattagga agaaaaaatg tcaatctata
    22381 ccaaaaataa agacgaaatt cggagatagg atataataaa aatcaagata cttaggtatc
    22441 aaaaggccct agttctgaag aaaggaatgg tggatattat gagaaaattt gacagaacaa
    22501 atatgaaata taacaacccg gctggagatc ttttgacaga attagaagca gcagatttga
    22561 caagtaacaa agttgatagt ttagcttcat caggtgtggt ttgcacaatt tctgttgaat
    22621 gcggaagtat ttttacactt gcttgttgct aattaaccaa agatgatttt agaactaggg
    22681 cctggattaa gagaaaggga gataacatga aaaaatctag ttatttatct gaaagagtgt
    22741 atgatgctat tccgtctgaa ataaatatgg agtctttaga gtattggaag aaaatactga
    22801 aggaggaagg attacaatat gtaaagaaaa accaccttga gtattttttt ggttttataa
    22861 ataattgtgc ttttagtagc cacgagaaga gtcaaccacg aaattttgtg aaattgtctt
    22921 tgaacaaaaa ggcgtttagg catgagggtg agaaaatggt tttcggagca ttttatgatc
    22981 cttttgtgca agaggcaaat agacagctta gagaaatagt tatacaaaga cgatatatca
    23041 atgaatcgat tctatttgat tttcagcaat ttttgtttaa ttcgcttaat aatctttgta
    23101 tccgaacttt aatttatgaa atgcatatat gtggacaaga aggcgtgtta aggggaaatg
    23161 aatctgaaca gtatcaatat tatatcgacc attttttaaa ggataaacaa tatttgaatg
    23221 atttattttc gctttatcca gtgttagaaa gaaggataaa tgaaattata caaaatgcga
    23281 tagatattta caaagaagtg atagagcgca ttgagaaaga tgcagatgtt ttaatgaaaa
    23341 aatttaatat cactgaaaaa ggatttgtcg taaaccatct ttcgacagat ttttctgatt
    23401 cgcataaaaa agggagaaga gtattttgtg tggaatttgt atcgggagat aaaattttat
    23461 ataaaccacg aagtttgcaa aatgagatta agctacaaga gattacaaat tatttctata
    23521 gaatatgtaa tttgggaagt tatgagtatt ctatacttga taaagaaatg tatggttggt
    23581 gcgaaattgt aatacaaaga gattgtaagt ctatagaaga actttcaaga tattatcaaa
    23641 gaatagggat tattttgttt ataaattatc ttttggaagg aggagatatt cattttgaaa
    23701 atctcattgc atgcaatgaa tatccagtta ttattgatgc ggaaacattt ataggaaata
    23761 tagaagagaa taatgggaaa agtgcagcag aaaaagtggc tagtctttta agaaaatcgg
    23821 tgttgtattc aggaatactc cccttttatt catggaataa cgcaggagat acaggaatca
    23881 atatgagtgc cattagtgga gaagaaggac aaaaattccc gataaaaatc ccctttatta
    23941 tcaatccgaa gtcggttaac atgagggttg tctatgatta tccagtatcg aaaggaaatc
    24001 acaatttggc aatgctaaaa ggaaggttta ttcaaccctc cgaatttgca gataaaatta
    24061 tccagggatt tgaaagtgca tacttaggtg caatggaaaa tacagaaaca ctattaagaa
    24121 tcatacaaca atatggtgaa ttagaggtga gatatctgat tagaaataca caacagtatg
    24181 caattgtgtt gagtagttca tatcatcctg aattattagt ggatggagga gcacgaaatt
    24241 tattttttta ttcattggca aatggaaatc ttcaaaatca aaggagtaga tctcttattg
    24301 agtatgaaat tgaagattta ttaagtggtg atataccgta tttttatttt cgtggaagta
    24361 aaaaaaacat ttatacttgg gatggcagag aagtaaagga tttctttagt aagccagctt
    24421 tgcagcaaat tgaggaaaat atacagaatt tgtcctataa gaatttagaa caacagacgc
    24481 aatatattaa aattactttt aatatggaga atgcaggaac aaggaaaata aagaataaaa
    24541 ggttaaaact agatctttat agtaatatgg ccaaaacggc agaagaattg gcaaaagagc
    24601 tgctagataa aataggaaca aatgcgattt atagcgaaga tggagcagac gttaattgga
    24661 ttggcgtaaa attatttggt ataaaagaaa atcagtggat gatccaggca ttaccgaata
    24721 cattatatga tggtacggtt gggattaatt tggtattcca tttatatgaa tggatatacc
    24781 atgacagaaa atatcataag atttgtgagg ttttagataa tcgtttgttg aggtatattg
    24841 atactataag tgaaggggaa cagaatatcg aagactttaa tacaggaatc tttagcggcg
    24901 aaggttcgat tttatatacg ttgggtattt tatatgaaat atatgatgat atcaagtata
    24961 aggaatattt cgataagtgg ctaaattgta tggaaacact tatcttagaa gatcgtttgt
    25021 tcgatatgat ttcgggaaat tcgggaatag ttttggttct gattaatatg tatagaaaaa
    25081 caaaaaagcc tatttatcta caaaaagcta tacaaatagc agaacaattg atagagaata
    25141 tgattactga aaatggaaaa gttggttgga aatcagaggt ggttcctgaa gtattggcgg
    25201 gatttgcaca tggaaacagt ggttttatag aactattttc aagattatat gaggtatatc
    25261 cacaaacaaa atatttagat atcctttcaa gtttagtaga atatgaaaat tctttatact
    25321 cagaaaagga taataattgg attgatttaa gaaagttttc agaggttgat cagcataaga
    25381 gtcaaccaat agcgtggtgc catggagctg cgggtattct gttatccaga ttaaccttat
    25441 ataatgccat caagaattta ggagaaactg cattgcttca gcaagctatt aaagatataa
    25501 gccttgctaa aaataaatta attgaagacg ggttacatgc aggtttctgc ctatgccatg
    25561 gaaacatggg aaatttattg attttaaaaa gatatgcaga aatttttgat gataagcagg
    25621 taagaagcat ttgtgattct cgatttgaac agattttgga attccttaat gaggaaaata
    25681 tattaccaac agaattatac aatccaggtt ttatgactgg tttatcagga atcgcttatg
    25741 ctttgttaaa atataagatg cccaaattac cattgcttat aggagttgag ggaatatatg
    25801 atagaaatga agtttagtaa aaatgatgaa gaagatgggt tgttccgcat aagttcgaga
    25861 gacatagttg gattttataa ttgtagtagt aaacaagagc gtaagataac agacattata
    25921 aaatgctatg gaacaacaaa aagcataaaa gaagttgaac tgaaaaacat gaagccagag
    25981 gataatgtta cagtatctcg gtatatagag agaaatgtag gttcaattat aaacaaagat
    26041 tatgtgattg aaggctttct gggaatgggg aagttgtccg attgtaaaga cgaaatggtt
    26101 agcagattgg atatatctaa gagatactgc ttagaaatat tagtggcatt tcttcaagaa
    26161 gcagacatta ttattttgca tgaaatgttt gaaaatgttt ggaatcatac tatagaggaa
    26221 attttagttg aattttcact aagaggagca gtggttgtgt tctcagaaca tggtgaagaa
    26281 tcattgatga aattaccaat gcacagttac gacctaagtg gtaggtgtgt tggatggtag
    26341 aataattggg gaatatgatt tttcatattc cttgagatat atagggtaga aaatatattt
    26401 agctgcaatg ttttgtccct ccatagttaa cgaatctatc taaataagaa ataggttata
    26461 tcaaacagat tttacaaagg agaaatacat ggagagagtt ttaataatat cttatattat
    26521 cagtatgata cttacggcag gctttattta ttgtatttat agagagaaat attgggtttt
    26581 tgaatttgta aacagaataa agaagccgat acagcaactt gtttatgttt ttcttatgct
    26641 cctatcatcg tatgcctata tatgcttttc gttactcata aaggctgatt ttaatgctgt
    26701 gatatgtgcg gtgctattac ttcttttgat ttgggctatg gactatctgt tttctttatg
    26761 ttttaaaaaa aatgatttgg ggataagtga aaaaaaacgc tatattttta tggcgtatgt
    26821 gggagcctgc atatcgggat ttattattgc aagtcgtgat gcttcgaaaa tggctttaga
    26881 aattccaaat ataacaatta gcgttttgat cggagcttat gtacctttta cattattatt
    26941 agaggatggg aaaaaaggga aagtagaatt gcaaagtatg aaagaagaat gggaggaaaa
    27001 gtataagaag acatttcgtg aacgtaaggt caaagacatt ctttctgctc tactatttgc
    27061 gatggtatat ggcgttttac tggtaggggc gttatctcct gctcaaaata tcatcaatga
    27121 tattgcttca gggataggaa tggggatggc tacagtggtt gttgcctttg tagggttggt
    27181 tgaagtgaaa aacaggttaa cgaaaaggag gaataaaaga gaagacgcag atcaagagaa
    27241 atccgataca gagtagaagg ggcaagacag caaggagtat ttagccggaa ttatttcaaa
    27301 tgtacctcac aagattggat gttgatgcga tataaatgat atgatatact gaagtccata
    27361 ttattagatt tgtggagaaa tagggatagc caagagaaaa aatataaaat taaattttgc
    27421 agaaagaagg catttttatg aaacttgtag gaagcagaaa attaacatgg ggaatttgca
    27481 gtattggtgt tttattagca atagtaagcg tgtttttctt acctcagatt attcctgttc
    27541 attttgcaaa tgggatagca gatgattttg gaaataaggt agagattttt ttatttccta
    27601 ttttgttaat cataattaca cttttgactg gaaaagaaaa cattaaatat ttcctgacac
    27661 attcaaaaac atttttgaca gatatacagt ataatttgat gatagatggc gttctcggaa
    27721 ttgttttgat tgcagaaatt tatgttattt atgcttcatt tgtttaagtg tttcaacaaa
    27781 aaattccagt tgtgtgccca gctaagggtg tgtagtcaag ccggtgggat tccggttta
//
