LOCUS       NZ_QSIO01000003        22973 bp    DNA     linear   CON 17-SEP-2024
DEFINITION  Streptococcus parasanguinis strain AM33-3BH AM33-3BH.Scaf3, whole
            genome shotgun sequence.
ACCESSION   NZ_QSIO01000003
VERSION     NZ_QSIO01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus parasanguinis
  ORGANISM  Streptococcus parasanguinis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 320886)
  AUTHORS   Zou,Y., Xue,W. and Luo,G.
  TITLE     A genome reference for cultivated species of the human gut
            microbiota
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 320886)
  AUTHORS   Zou,Y., Xue,W. and Luo,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2018) BGI-CNGB, BGI, No. 11, Beishan IZ., Yantian
            Dist., Shenzhen, Guangdong 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina Hiseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003468585.1-RS_2024_09_17
            Annotation Date                   :: 09/17/2024 04:49:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,096
            CDSs (total)                      :: 2,058
            Genes (coding)                    :: 2,033
            CDSs (with protein)               :: 2,033
            Genes (RNA)                       :: 38
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 25
            CDSs (without protein)            :: 25
            Pseudo Genes (ambiguous residues) :: 0 of 25
            Pseudo Genes (frameshifted)       :: 3 of 25
            Pseudo Genes (incomplete)         :: 24 of 25
            Pseudo Genes (internal stop)      :: 2 of 25
            Pseudo Genes (multiple problems)  :: 3 of 25
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:30:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 34587
            Orig. end                         :: 57560
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QSIO01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22973
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22973
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22973
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12973](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12973)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(233..679)
                     /locus_tag="DW820_RS07235"
                     /old_locus_tag="DW820_07235"
     CDS             complement(233..679)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004183428.1"
                     /locus_tag="DW820_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07235"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_070590515.1"
                     /transl_table=11
                     /translation="MKVRIELDPSMDEPEILIRAPRLTPELTQLQERILEQKIASLAFY
                     KDRSEYFLDVASILFFETDGEKIFGHTKDEAYEVKQKLYELEELLPIAFCRISKSTIVN
                     AKQIYSLEKSFSGTSTVNFYQTHKQVHVSRRYYQLLKERLNEMR"
     gene            complement(980..1291)
                     /locus_tag="DW820_RS07245"
                     /old_locus_tag="DW820_07245"
     CDS             complement(980..1291)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006594989.1"
                     /locus_tag="DW820_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07245"
                     /product="hypothetical protein"
                     /protein_id="WP_070590581.1"
                     /transl_table=11
                     /translation="MKKLLGLGFILAAFVIVTMGMVGFPKLDVNIWPLFPVLLFAFFTL
                     ENLLKKDYKASVICALIALMIANAIYGLLPVSNGLVITAGVLACLGLSFLLPDKESNK"
     CDS             complement(1343..1507)
                     /gene="allorf_035930_036094"
                     /locus_tag="allorf_035930_036094"
                     /protein_id="allorf_035930_036094"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLAIGIEKICFEGARRRMMLVTYSFCLVSFFDRIGTIFDRLVKSP
                     CRRWGSLLS"
     CDS_motif       complement(1436..1507)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLAIGIEKICFEGARRRMMLVTYS"
                     /locus_tag="allorf_035930_036094_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(1343..1435)
                     /prepeptide="core"
                     /locus_tag="allorf_035930_036094_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="3430.0"
                     /monoisotopic_mass="3427.8"
                     /core_sequence="FCLVSFFDRIGTIFDRLVKSPCRRWGSLLS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLAIGIEKICFEGARRRMMLVTYS"
                     /leader_location="[1435:1507](-)"
                     /alternative_weights="3448.1"
                     /alternative_weights="3466.1"
                     /alternative_weights="3484.1"
     misc_feature    complement(1380..1395)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.08"
                     /tool="antismash"
     misc_feature    complement(1392..1405)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.62"
                     /tool="antismash"
     misc_feature    complement(1785..1798)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     gene            complement(1795..3252)
                     /locus_tag="DW820_RS07250"
                     /old_locus_tag="DW820_07250"
     CDS             complement(1795..3252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000129936.1"
                     /locus_tag="DW820_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07250"
                     /product="nucleotidyltransferase"
                     /protein_id="WP_118095857.1"
                     /transl_table=11
                     /translation="MTDITISREIKSIIEELDVSYSKYEIATNRYNSIANYIKNSELSK
                     NSPDIYLQGSFKLGTAIKPLTEDGAFDIDIVCNFTKLRRNDQSQYSLKNNLGEIVKSYA
                     KAQSMSSGPEESKRCWTLKYVDESNFHIDILPSVPLNEKNDGFIAITDKTHENYFKITS
                     NWETSNPKEYAKWFRDLSKFSIYQKEVAKRFYASIEKVPEYRVRTPLQRIVQILKRHAE
                     VCFEKDIEYKPSSIIITTLAAKQYQSASTIYSDFLDIINYVIEHLKDAIEFRNGKPCVY
                     NPVNKDEVLSNKWDKDSSYFEAFEKWLEQLKLDFNVANYNLSYLDKIKFIRTSLFKNSG
                     EQFPIVNVNSISHHQNSKWKEFLIEDVSIKASYLYKGFRWKKIESGTKLNKHGSLKFEV
                     QANSILGYEIWWQVTNTGREAELANSLRGGFYNSELVEGKRVRKESTLYTGRHYVEAYL
                     VKNGICYGKSIPFEIIITDKFSIDFAH"
     gene            complement(3265..3966)
                     /locus_tag="DW820_RS07255"
                     /old_locus_tag="DW820_07255"
     CDS             complement(3265..3966)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000404289.1"
                     /locus_tag="DW820_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07255"
                     /product="hypothetical protein"
                     /protein_id="WP_118095858.1"
                     /transl_table=11
                     /translation="MEILHDLIVNLVVAVITFFVSTIFNNRRRIKIWSQSLIRWNKDIR
                     LSCAYLFQIKQTNGRYLLIKGRRIDQYQPIGGVYKYHDSFKGLKEEFELKDESETRFYE
                     SGDLRLITKGKHLVQFINWFDTRKNREVTVIRELIEELEPAGISIEDLVTKSQVEYLKT
                     VKEPIMFSTYFQMDELKIFDIFEARIPTEILDKVLENDDYCLIEAEDIEKNCFAKDGLS
                     KKISATSKYIV"
     gene            complement(3996..4079)
                     /locus_tag="DW820_RS07260"
                     /old_locus_tag="DW820_07260"
     CDS             complement(3996..4079)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024555.5"
                     /locus_tag="DW820_RS07260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07260"
                     /product="hypothetical protein"
                     /protein_id="WP_118096035.1"
                     /transl_table=11
                     /translation="MDAIQVKFYNHSNQKSDIDSFLGELGQ"
     gene            complement(<4268..4462)
                     /locus_tag="DW820_RS07265"
                     /old_locus_tag="DW820_07265"
                     /pseudo=""
     CDS             complement(<4268..4462)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611514.1"
                     /locus_tag="DW820_RS07265"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07265"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLTYEDKVQIYELRKQGESFRRLSNQFGINISNLQYMIKLIDRY
                     GIEIAKKVKNRYCFPKLKIE"
     gene            complement(4538..5833)
                     /locus_tag="DW820_RS07270"
                     /old_locus_tag="DW820_07270"
     CDS             complement(4538..5833)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358184.1"
                     /locus_tag="DW820_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07270"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_049518571.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1e-35, bitscore:
                     117.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLFRLVILSVCFLCVGKVYAENVSNLSYMITNREVWKISEIKR
                     KIDSNKISYIPEINLLSFHNLDNEDQNIISKYFDLKKGNSLPKIDIQKEIEVDTISNSQ
                     TESIHNDSVSNSIYGKTDILSEEYNSFNWPYKKILSDRILNGDIRGEGIKVGIIDSGVD
                     FSHPNLVDNNLKQKNYVNDDQTDELGHGTQVAGVIDTLAPGVEMTSYKVMGAEEGESLN
                     VIRAIIDATNDGMDIINVSLGSYKNYTKGEEKFTTIAFLKAIEYARRNKTIIVASAGNE
                     SINLDTFSNNNMHVPGGLPSVITVASTNKKGNKADYSNYGSIISISSPTGSFGEQYATT
                     GQIDAREMMMTYYPLTKESIIGSLAGFPKGYTLSFGTSLAAPAVSAAVAVILSKNICQD
                     RDVESIILQLMRNSEPFKEDSENIGYGELRIK"
     gene            complement(5881..6255)
                     /locus_tag="DW820_RS07275"
                     /old_locus_tag="DW820_07275"
     CDS             complement(5881..6255)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DW820_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DW820_07275"
                     /product="hypothetical protein"
                     /protein_id="WP_049518570.1"
                     /transl_table=11
                     /translation="MKNDRSTYLTKKFIVLMAVTCFSIFPSVMIFGKIGFIIYAILFFW
                     TVKTSLEIEKIKKQNNLNTVSDLLKDKTTEEYKMIESDERVKNFISSLSQTKIILYTVI
                     VGVIITLFSVLIYYLIMEIV"
     gene            complement(6245..8377)
                     /locus_tag="DW820_RS07280"
                     /old_locus_tag="DW820_07280"
     CDS             complement(6245..8377)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="DW820_RS07280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07280"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_118095859.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.7e-36, bitscore:
                     119.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIRFQQQSEHSECGLACVAMLIDYFSENMRLTHLRQKYGVPNGG
                     YNFAQLTLIFSDYNISTRCIHVDYDRIRSVPTPCIAFWKESHFVIIERVDRKKYYIVDP
                     ALGRFCLNEEEFKECFSKAILYIDRKYSKKRNTFGIFNYYFKNLLKHFKIVFSVLVISF
                     SVQLLALSIPYIIRSIIDDPMMWKALDHSILGLTLIIISFLYFGTNYIKIKLIAKLQTT
                     IDRDLVTTVVKHLLDLPYSYFTNRNKGDLVYTLNSNSYIRQILIDQVIELIINFVFALL
                     YLIAMFLINTTLTFVTLIIVVLISGSLFINSFYNKKLTQNEITALSNSQNNINEMINNI
                     LTIKSTASKDNIFKNWVNNFEEQLYYEVKRANYSSIFINFSHSVQVLYTLIIYIVGIQL
                     NQAGVELTLGSIVGFVSIGVSFISPLISILSSYNQIFSISIYVNRLLDVLETPIEALLF
                     GGYRVENLSGLIEVNNLSFRYSKFSSDVLDNISFNIQEGEKIAIIGESGSGKSTLLKLL
                     SGFYKPSSGEILFDKHPIDKFDIESFREKIGVVLQEDRLFSGTLRENITLGRPISDKEI
                     WDIMLGSGLIDLVNSFPLGLDTIISENGNNLSGGQRQKISLIRTLISKPSIIFLDEPTS
                     SMDVLSEKQMMELIFKINCTVVVVSHRISLVDKFDKILIVKNGKIEGFDSHSRLIKNCP
                     YYNSLYYKIKELENEK"
     gene            complement(8388..9104)
                     /locus_tag="DW820_RS07285"
                     /old_locus_tag="DW820_07285"
     CDS             complement(8388..9104)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017369956.1"
                     /locus_tag="DW820_RS07285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07285"
                     /product="flavodoxin family protein"
                     /protein_id="WP_118096036.1"
                     /transl_table=11
                     /translation="MKKIFILIGSRRKKGNTYRFVKSIISNLSDFDVDYCFPQDLDIQP
                     CVGCHNCFQQAKCVLRDDISLLEDKILSSDIFIIASPVYLHYMTGDLKRILDRLSWWAH
                     TMRLQGKPVVVLSTNGSNGERSVTEPLSEIMTAMGGNVIANANASEFPNQINNNLWLSE
                     VSIEISERIKQYSRQRPSSNQFLETAFISEKFNILQQKEMAVRFPDWEFNELKFWEDTG
                     MLSFDSYSDYLSHRLK"
     gene            complement(9448..9687)
                     /locus_tag="DW820_RS07290"
                     /old_locus_tag="DW820_07290"
     CDS             complement(9448..9687)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03893.1"
                     /locus_tag="DW820_RS07290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07290"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_118095860.1"
                     /transl_table=11
                     /translation="MINEIDVNKYAGDSFEEMSIAEMTLVQGSGDMSAEFTPTTPACFA
                     SIIYTARASSASCANAISAISSAISGAIISAVKC"
     CDS_motif       complement(9601..9687)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEIDVNKYAGDSFEEMSIAEMTLVQGS"
                     /locus_tag="DW820_RS07290_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9448..9600)
                     /prepeptide="core"
                     /locus_tag="DW820_RS07290_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="4634.2"
                     /monoisotopic_mass="4631.3"
                     /core_sequence="GDMSAEFTPTTPACFASIIYTARASSASCANAISAISSAISGA
                     IISAVKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEIDVNKYAGDSFEEMSIAEMTLVQGS"
                     /leader_location="[9600:9687](-)"
                     /alternative_weights="4652.3"
                     /alternative_weights="4670.3"
                     /alternative_weights="4688.3"
                     /alternative_weights="4706.3"
                     /alternative_weights="4724.3"
                     /alternative_weights="4742.4"
                     /alternative_weights="4760.4"
                     /alternative_weights="4778.4"
                     /alternative_weights="4796.4"
                     /alternative_weights="4814.4"
                     /alternative_weights="4832.5"
     gene            complement(9697..9903)
                     /locus_tag="DW820_RS07295"
                     /old_locus_tag="DW820_07295"
     CDS             complement(9697..9903)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03893.1"
                     /locus_tag="DW820_RS07295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07295"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_118095861.1"
                     /transl_table=11
                     /translation="MLDVQDSIVTGAAFEDMSIAEMTRVQGSGDISPETTPACVLIISN
                     VISGAAVSFKFSVDVVKTLKGKC"
     CDS_motif       complement(9820..9903)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLDVQDSIVTGAAFEDMSIAEMTRVQGS"
                     /locus_tag="DW820_RS07295_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9697..9819)
                     /prepeptide="core"
                     /locus_tag="DW820_RS07295_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.00"
                     /molecular_weight="3951.6"
                     /monoisotopic_mass="3949.2"
                     /core_sequence="GDISPETTPACVLIISNVISGAAVSFKFSVDVVKTLKGKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLDVQDSIVTGAAFEDMSIAEMTRVQGS"
                     /leader_location="[9819:9903](-)"
                     /alternative_weights="3969.6"
                     /alternative_weights="3987.7"
                     /alternative_weights="4005.7"
                     /alternative_weights="4023.7"
                     /alternative_weights="4041.7"
                     /alternative_weights="4059.7"
     gene            complement(10001..12973)
                     /gene="lanM"
                     /locus_tag="DW820_RS07300"
                     /old_locus_tag="DW820_07300"
     CDS             complement(10001..12973)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="DW820_RS07300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07300"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_118095862.1"
                     /sec_met_domain="DUF4135 (E-value: 7.7e-93, bitscore:
                     305.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.8e-29, bitscore:
                     95.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDYIVSSAQTIREKSKFFNENIEIDYTFLKEWRNVRTLMTDELF
                     ELMLKEEGYTLEEFANSLRESNEFADNPEWYDKFLFIIQNYDYNNINYEAGISVLTLPF
                     SKYTLDNIKSKISNLDNFRVDEEIFDKIILYQNDELFNLIGKIMALKLAEYKKENNFSN
                     RNGVFEKFLEDKFYSKESFIQFFEEYPVTARLLTVRTQFFIDNISNFFNNLNNDTYDLK
                     NFFNLSEVVITDLELAAGDSHENGKSVIIFEVNHIQKIVYKPKNLKIEERISELLKWFS
                     SEELLDLHLPKGLYRNNYTYNEFVYRKPCNCIEEVQRFYIRFGYLIALCYLLGIDDLHL
                     ENVVASSEYPIVIDIETAFHLSSKITPDDIFNNILQELEHDSIKGSCLLPRKIPVGMDG
                     AIELSALIGKGGETSSTVSTPININSDDFRYSEKNVYFSSGNNIPIYKGQEVDSKDYRF
                     KIIEGFEDFFDFVLKNKIELLRRVEQFKNIKVRILLKGTEKYASMLRYSSHPNYGKRMK
                     YRERLFMNIWAYPYLDKRVVKSEVRDLLFGDIPIFYNNIGSKDLIDSQGNIYQNYFLES
                     GLDKYKKLIASLSQDIVDKQKDILFMELGLYDEYLSFRKEKTNRKIQNYSINYIREAKQ
                     IAKYLMDNTKKYEEMISMVNLDSDREYHWSFQPMNESFYGGLSGIALFFLELYNVTKEP
                     IYFHYYKGYISSAILQTRNTTFQSPFFGWLSPMFPLLLEYKYNSTLVDEKYFRFTIDKL
                     NTLTSEDVYKIEKIDYISGISGVITLLHQINLVYPLKISSTTIGMFYQVLMERSKGDKE
                     LKSKPGLAHGIAGLAISRSLDQGLEEFAYNYSSLEVDNLPKLSDRYKWCLGLAGIIQAK
                     LSMYYNASSYINIKDLYVLFKEFEHSLMVSSIDDDSLCHGSAGVIITLSLVYKFTGEKK
                     WNDMLKNQLYKLKLNSLFDSYLLPRVGKTYSLGLFDGIAGIGWMYLFLENKCSNIMMLG
                     F"
     misc_feature    complement(13012..13025)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            13591..14457
                     /locus_tag="DW820_RS07305"
                     /old_locus_tag="DW820_07305"
     CDS             13591..14457
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373454.1"
                     /locus_tag="DW820_RS07305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07305"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_049518568.1"
                     /transl_table=11
                     /translation="MQSIGNKIKTKRKSLGLSQKDLADGICEQSLISKIERTNYFPSAD
                     VLYNLSQKLQVDINYFFDESYETVSDLRNFIAMSSKLLEHRNYNDLEYLYNLEKSNQNS
                     FNEDEQSYLTWIEAIILFYNYDQKDSAIELLKNLIDSFLDYKKNIYLKALNTLTNFYSN
                     IGYNEEYEKNYKQLLQIYSTKDFQLKEDIEGYIRLKYNFAHHLTINGQLLDALETALET
                     IDFCKNNNTAYQMPSLLLLVANSCEKFLSKEEILQYYTDAKTLAKLYGNDVLYLKIKNY
                     LINYNSD"
     misc_feature    complement(13602..13618)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.35"
                     /tool="antismash"
     gene            complement(14957..15205)
                     /locus_tag="DW820_RS11080"
                     /old_locus_tag="DW820_07310"
     CDS             complement(14957..15205)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022172.5"
                     /locus_tag="DW820_RS11080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07310"
                     /product="DUF2513 domain-containing protein"
                     /protein_id="WP_220432874.1"
                     /transl_table=11
                     /translation="MIVKILADAGLLDSYEPTYGDDRIYAFSVGSLTWAGHDFLDKIRE
                     NTLWNRTKDNALPMSLEVIVIIIKWVTSFLNRDCHKK"
     gene            15418..15777
                     /locus_tag="DW820_RS07315"
                     /old_locus_tag="DW820_07315"
     CDS             15418..15777
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819423.1"
                     /locus_tag="DW820_RS07315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07315"
                     /product="hypothetical protein"
                     /protein_id="WP_118095863.1"
                     /transl_table=11
                     /translation="MRKIIGILLLSLSIITLIACSKNNYQSLDGEYYWISSERNELAFT
                     IKGNRGSIEHGEADNFTIDQENNTFHLSGEGTTDSTVKYKVKDGTITVDISGIEHEYYQ
                     KGSEAYNKALQQYNK"
     gene            complement(15899..16543)
                     /locus_tag="DW820_RS07320"
                     /old_locus_tag="DW820_07320"
     CDS             complement(15899..16543)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014712928.1"
                     /locus_tag="DW820_RS07320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07320"
                     /product="hypothetical protein"
                     /protein_id="WP_118095864.1"
                     /transl_table=11
                     /translation="MKKWTSLALLGLTSATLLVACGSKKEENSSSVKETQTTMTSGKNK
                     TNQSSKKKNTKETESSSEETTQSSQTTTASNTTSGDKATDSSQMVPAELVGTWTGTTEI
                     AKDVQMTVAADGTVTTTANFYQADVNPMRTATTRAKAVQASGNIYYWETDEPGAFDALL
                     PGIAGLGGANAKVKAGFILEEGHYTPIVFVTGLNEEFDYSKYNDFRVSLTK"
     gene            complement(16745..17419)
                     /locus_tag="DW820_RS07325"
                     /old_locus_tag="DW820_07325"
     CDS             complement(16745..17419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595231.1"
                     /locus_tag="DW820_RS07325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07325"
                     /product="LexA family transcriptional regulator"
                     /protein_id="WP_118095865.1"
                     /transl_table=11
                     /translation="MFNGTKLKQKREELGMKQSEIARLLDINRSSYFSWENGRAVPNKA
                     NLKKISEILGVIEEFFYEEEIATLYKQLNPTNQTKAMNYVKDLVDKQSNIIAMPTVPYR
                     VYESLSAGIGSSVYNDQNYDTVYFHEELAHDFASWISGDSMEPKYQNGSVALIRETGFD
                     YDGAVYAVVCNNQTYIKRVYREEHGLRLVSINPNYKDIFLSYDEDPRIVGIIVGNFVPM
                     KL"
     gene            complement(17421..18287)
                     /locus_tag="DW820_RS07330"
                     /old_locus_tag="DW820_07330"
     CDS             complement(17421..18287)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003058906.1"
                     /locus_tag="DW820_RS07330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07330"
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_118095866.1"
                     /transl_table=11
                     /translation="MDTRYSQIKEVANHYIYKYIKENDSSLLGYDFEGFFNHVIEIHNI
                     KVMEHHFSSRKIEGLTLIDESGVSFSYEKENPQVKQNFTKCHELGHFLLKHTGSFFTEL
                     KDESCSIFESEANLFSAFVLMPSIVLLSKIFYRHDSFSRVMKDLKVSAEALVYRLRDLF
                     SHETTHSLDEVNHAIQDYKNGQLDRIMNMFSLLKSSIIAEYQQVMIDMLAKIYHLLTRD
                     SYLSDRQIYELKDKKFRQTLEAEKSDISCGQLFDYGKVIYFAWKKDRLTERQAVSNAKT
                     QLLLERA"
     gene            complement(18365..19459)
                     /locus_tag="DW820_RS07335"
                     /old_locus_tag="DW820_07335"
     CDS             complement(18365..19459)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DW820_RS07335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DW820_07335"
                     /product="hypothetical protein"
                     /protein_id="WP_118095867.1"
                     /transl_table=11
                     /translation="MTQRSKIKHTILGTIFPIISLIMILVVFVVEKLNFLDYNPLHWLI
                     LNNVLVLILNNKEDKAEKTVSKEFKFLRKQFIQILHFIEFIGSSLIMERMISYGVKIDE
                     NSKKNIFLVFALIFLIFLLYKILETGVTVLFASFSEKVYEFKFFSRVGLVVSFSVFSIL
                     LLLILSDTIISELFFSVLIYVIGMWYLSEDRYIIFNQVYPSSITKKRELSFLRTLLTVE
                     LISFSISKVLIENNWFPIKQLENFFEKSEFKSAWVNLILTLMVFLFLMIILVIISIILR
                     KKQNQCDEEASSETELVNVADIEEGNETELVNITDTEEEKVKRVSLVIVSNRKYRQKKH
                     KKYHRGYVYNKKGDKCLLWKLFKS"
     gene            complement(19459..19800)
                     /locus_tag="DW820_RS07340"
                     /old_locus_tag="DW820_07340"
     CDS             complement(19459..19800)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395812.1"
                     /locus_tag="DW820_RS07340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07340"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_118095868.1"
                     /transl_table=11
                     /translation="MDLAEHLKTLRKQAKMTQAQVAKAIEISQQGYAYWEQGKKRPSYD
                     NLVKIAKLFNISVDTLVSNKTNDDIDLSEVELLFRSTSDGMSNEEKEVFKQELLHFMKE
                     RKKLFDGEK"
     misc_feature    19830..19843
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    complement(19831..19844)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.95"
                     /tool="antismash"
     gene            20466..20648
                     /locus_tag="DW820_RS07345"
                     /old_locus_tag="DW820_07345"
     CDS             20466..20648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149311.1"
                     /locus_tag="DW820_RS07345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07345"
                     /product="hypothetical protein"
                     /protein_id="WP_000490640.1"
                     /transl_table=11
                     /translation="MFSESDKLQAKLYAQAQIDLDHLADDARRNGYAHGDIQFYSRMFK
                     RKLFTHYYSRVKQLA"
     gene            20683..20979
                     /locus_tag="DW820_RS07350"
                     /old_locus_tag="DW820_07350"
     CDS             20683..20979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595224.1"
                     /locus_tag="DW820_RS07350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07350"
                     /product="cytoplasmic protein"
                     /protein_id="WP_118095869.1"
                     /transl_table=11
                     /translation="MISETLKMKPEFIGPAYYERLGDAPKSIFRKEGKYQRHILNSAEH
                     GAFHVITPASTTVFPEDALVEAVNPIFFPDTALNGNTVAPYLNVFAEKLVLKK"
     gene            21001..21462
                     /locus_tag="DW820_RS07355"
                     /old_locus_tag="DW820_07355"
     CDS             21001..21462
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904644.1"
                     /locus_tag="DW820_RS07355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DW820_07355"
                     /product="conjugal transfer protein"
                     /protein_id="WP_070888886.1"
                     /transl_table=11
                     /translation="MAKIGLNYGEKLQIADKTYRVITDGLDVPAVLGKLTFRGIEGPDI
                     IFEVDRSQRNPDGSFVQVNTGEIRGIVVGIHSSVQHETLFFTIADMSESEIEDLGIKYR
                     EEVELEDIVITHTHVNRNDIYKLFASKIKKKAGGAPSKENKPVENKKEN"
     misc_feature    complement(21567..21582)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.96"
                     /tool="antismash"
     misc_feature    complement(22246..22260)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(22422..22436)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.1"
                     /tool="antismash"
     misc_feature    22815..22833
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.73"
                     /tool="antismash"
ORIGIN
        1 ggacactgga aggaaatggt attgcccatt gagacaaaag agagctaaaa gtccatagat
       61 gaagccccaa ccaaaatggc gttttaagaa actagagagg gacaggacgg caagcaaggt
      121 gacccaagcc aaggtccaga tgctgatgtc ccattttaca aaatagccct gtaagagtag
      181 taaggctgct aatagaatta agaatacccc aattaatttt tttctcatga tattacctca
      241 tttcatttag tcgttctttt aagagttgat aatagcgtct agatacgtgg acctgcttat
      301 gggtctggta gaaattgacc gtgctggtcc ctgaaaaaga cttttccaga gagtagatct
      361 gctttgcatt gacaatggtg gatttggaaa tccgacaaaa ggcgatagga agcagctcct
      421 ccaattcata gagcttctgc ttaacctcat aggcctcgtc cttggtgtgc ccaaaaatct
      481 tctccccgtc cgtctcaaaa aagaggatcg atgccacatc cagaaaatac tcacttcgat
      541 ccttgtagaa ggctaaagaa gcgatctttt gttccaggat tctctcttgc agctgggtca
      601 actccggggt caagcgcgga gctcgaatca agatctcagg ctcgtccata gatggatcca
      661 attcgattct aactttcata aaactccttt cccaacgttt tgatagtacc attataacag
      721 ctgttgaaaa caaaacaagg gcttttcagt aagtggcacc ttttccccat caagaggtag
      781 tttttgagaa gtaaaagaga gagtgggaca gaaatcggta attcgttaga attcgattcc
      841 gtcgttccac ctccgcacag ttgagtaggg ctgtataagc tgatgaaatc agcgtattag
      901 agcccactca accactgcgt cttgctctac aatccaaaga caattgagag gctaggactt
      961 ttatcccagc ctccttcctt tatttattgc tttccttgtc cggtaaaaga aaactaagac
     1021 ctaggcaagc aagcacacct gctgtgatga ccagaccatt tgagaccggt aaaagaccgt
     1081 aaatcgcatt tgcgatcatc agagcaatca gggcacagat aacacttgcc ttgtaatctt
     1141 ttttcaagag attttcaagt gtaaagaatg caaataagag aacaggaaat aggggccaga
     1201 tgttcacatc gagctttgga aaaccaacca ttcccattgt gacaatcaca aaagcagcca
     1261 aaataaatcc aagtccaagt agttttttca tcatcatata cctcattttg attattcgga
     1321 agtacttctt cctttgatga ttctatgata acagagagcc ccatcggcga caaggacttt
     1381 tgactaagcg gtcaaaaatg gtgcctatgc ggtcaaaaaa agaaacgaga cagaacgaat
     1441 atgtgactaa catcattcgt cgtctcgctc cttcaaagca gattttttct atgccgattg
     1501 caagcattct agttgtttgg acgaactaaa ctcaacaata atataccgaa tttaaagcta
     1561 atttaactaa attagatttc atatacaaat agactaaaat tcaatttggt acaaatttgg
     1621 tacaaataaa acttttcgta aaacctggtt tggaaagtat gggtttcaag taattttaga
     1681 ttagctttat ctcaattatc aacaaagtcc gacatctttt tcattcaaaa atttagaatg
     1741 agtttgattg aaggaaggga aatatcaaat aaacaactta ccggttaatc tccgtcaatg
     1801 tgcaaaatct attgaaaatt tatcggttat aataatctca aacggaatac ttttcccata
     1861 acaaattcca ttcttgacta gatatgcttc tacataatgt ctaccagtgt aaagagtact
     1921 ttcttttcta actcttttac cttctactaa ctcagaattg taaaacccgc ctcgtaaaga
     1981 atttgctaat tcagcttccc tgcctgtatt tgtcacttgc caccaaattt cataccctag
     2041 tatactatta gcctgtactt caaatttaag actaccatgt ttattcaatt ttgttccgct
     2101 ttcaatcttt ttccacctaa atcctttata tagataactt gcctttattg atacatcttc
     2161 tatcaaaaac tctttccatt ttgaattttg atgatgactt atagaattga cattaacaat
     2221 tgggaattgt tctccactat tcttaaataa gctagtcctt ataaatttta ttttatctaa
     2281 ataagataaa ttataatttg ctacattaaa gtctaattta agttgttcca accatttttc
     2341 aaatgcttca aaatagctac tatctttatc ccatttatta gatagaactt cgtccttatt
     2401 tacaggatta tatacacaag gttttccatt tctaaattca atagcatcct tcaagtgttc
     2461 aataacatag tttataatat ctaaaaaatc actataaatt gtactggcag actgatattg
     2521 ctttgctgct aatgtcgtga tgattataga gcttggttta tattcaatat ctttttcaaa
     2581 acaaacctca gcatgtctct tcaagatttg aacaatcctt tgcaagggag ttctaactct
     2641 atattcagga actttttcaa tagatgcata aaatctttta gcaacttctt tttgatagat
     2701 agagaacttt gaaagatctc taaaccactt agcgtactct tttgggttac ttgtctccca
     2761 attagaagta attttaaaat agttttcatg tgttttatcc gtaattgcta taaacccatc
     2821 atttttttcg tttaaaggga ctgacggcag tatgtctata tgaaaattgc tttcatcaac
     2881 atattttaat gtccagcagc gtttgctttc ctctggccca ctggacattg actgagcctt
     2941 agcgtaactc ttaacaattt ccccaagatt atttttcaaa gaatattgag attggtcgtt
     3001 tcttcttaac tttgtgaagt tgcaaactat atcaatatca aaagctccat cttctgttaa
     3061 tggcttgatg gctgttccca atttaaacga tccttgcaag tatatatctg ggctgttttt
     3121 gctaagttct gaatttttga tatagttagc aatagaattg tatctattag tagctatttc
     3181 atatttcgaa tacgaaacat ccaattcttc aataattgat ttaatctctc ttgagatagt
     3241 aatatctgtc aaagtatctt cctcctaaac aatatacttc gaggttgccg aaatcttttt
     3301 agaaagtccg tctttagcaa aacaattttt ttctatatcc tcagcctcta ttagacaata
     3361 atcatcattt tctaatactt tgtctaatat ttctgtaggt attcttgctt caaaaatgtc
     3421 aaatattttt aattcatcca tttgaaagta agttgaaaac atgattggtt ctttgacagt
     3481 tttaagatat tcaacttgcg actttgttac taggtcctct atagaaattc cagcaggttc
     3541 taattcttca ataagctctc taattacagt tacttcccta ttttttctcg tatcaaacca
     3601 gttaataaac tgtacaaggt gcttcccttt tgttattaat cttagatctc cactttcata
     3661 aaatcgagtc tcagattcat ctttcaactc gaattcttct tttagccctt tgaaggaatc
     3721 gtgatattta taaacacctc ctataggttg atattggtct attcttctcc cttttatcag
     3781 caaatagcgg ccattagtct gtttaatttg aaataggtaa gcacaactca atcttatatc
     3841 tttgttccat cgaataagag actgagacca tattttaatt ctacgtctat tattaaatat
     3901 tgtcgagaca aaaaaagtaa taactgcaac aactagatta acaattaagt catgtaatat
     3961 ctccaaaact actcctccac ttcaaacttc gtagactatt gaccaagttc accgaggaag
     4021 gaatcaatgt ctgacttttg gttactatga ttataaaatt taacctgaat agcgtccagc
     4081 tcaccagtat gccaagagac ctataggatt gtttaagtat gtcagtactt aactaaaggc
     4141 tccttagtga ttatagttag aactattata acctttttaa gttcaaaaaa atagcattca
     4201 ctgcatagta acgctatttt gaacctatat accaatattt tctgattaag ttattatctt
     4261 gtccactttc tatttttaat ttaggaaaac aataacgatt ctttactttt tttgcaattt
     4321 ctattccata acgatcaatc aatttaatca tgtactgaag attagaaatg tttatcccaa
     4381 attgattaga aagacgtcta aagctctctc cttgctttct caattcatat atttgaactt
     4441 tatcttcata agttaatttc ataataaaag caccccaaaa gttagatttt ttctgtctaa
     4501 cttttaaggt gccgttcatt gatacaatga atttttttca tttaattctt aactcaccat
     4561 agccaatatt ctcagagtct tccttaaatg gctcggaatt cctcattaat tgtaatatga
     4621 tgctctcaac atctctgtct tgacaaatat ttttagacag aatcactgca acagcagcac
     4681 tcacagcagg ggctgccaag cttgtcccaa aggaaagagt ataccctttt ggaaatccag
     4741 ctaaagaacc aattatagat tcttttgtca atggatagta agtcatcatc atttcacggg
     4801 catcaatttg acctgttgtc gcatattgtt ctccaaaact tcctgtaggg cttgagatac
     4861 taattataga accatagttt gagtaatctg ctttattacc cttcttatta gtagacgcta
     4921 cagtaataac tgaaggaaga ccaccaggaa catgcatgtt attgttactg aaagtatcaa
     4981 gattaattga ttcatttcct gccgaagcta caataattgt tttgttcctt cgggcatatt
     5041 caattgcttt taaaaatgca atagttgtaa atttttcctc ccccttcgta taattcttat
     5101 aagatcctag actaacatta attatatcca taccatcatt ggtagcatca attatagctc
     5161 taataacatt tagagactcc ccctcctcgg ctcccataac tttgtaagat gtcatttcta
     5221 ctccaggagc tagagtatct atcacaccag ccacttgagt cccgtgaccc aactcatctg
     5281 tctgatcatc atttacgtaa ttcttttgtt taagattatt gtctactaga ttagggtggc
     5341 taaaatcaac acccgaatca attattccaa ctttaattcc ctctcctcgt atatccccat
     5401 ttaatattct atctgataaa attttcttat atggccaatt aaaactattg tattcctctg
     5461 agagaatatc tgtttttcca tatattgaat tacttactga atcattatgg attgattcag
     5521 tttgactatt agaaatggta tcgacctcaa tttctttttg tatatctatt tttggaagag
     5581 aattgccttt ttttaaatcg aaatatttgg agattatatt ctgatcctca ttatctaaat
     5641 tatgaaaact taaaagatta atttcaggaa tatatgatat tttatttgaa tctatttttc
     5701 ttttaatttc tgaaatcttc caaacttctc tattcgtaat catataagaa agattactaa
     5761 cattttcagc atatactttt ccaacgcaaa gaaaacatac tgataatata actaagcgaa
     5821 ataataattt cattttccat tcccctctac gatgaaattt ataaatttat aacgtcaaac
     5881 ctaaacaatc tccataataa gataataaat aagaaccgaa aacagtgtta ttattacccc
     5941 aacaatgacc gtatataata ttatttttgt ttgacttaaa ctacttataa agttttttac
     6001 cctttcatct gattctatca ttttatactc ttcggtagtt ttatccttta ataaatccga
     6061 tacagtattt aagttgtttt gctttttaat tttctcaatc tcgagcgacg tctttacagt
     6121 ccaaaagaac aagattgcat aaattataaa tcctattttc ccaaaaatca taacagatgg
     6181 aaaaatacta aaacatgtta ctgccattaa tactataaat tttttagtaa gatatgtact
     6241 tctatcattt ttcattttca agctccttta ttttataata gaggctgttg taataagggc
     6301 aatttttaat taatctactg tgtgaatcaa agccttcgat ttttccattt ttaacaatta
     6361 atattttgtc aaacttatca actaaagaga ttctgtgcga aacaaccaca actgtacaat
     6421 ttattttgaa aatcaactcc atcatttgtt tttcagacaa tacatccata gaactcgttg
     6481 gttcatcaag aaatattatt gatggttttg aaataagtgt tcttattaga gatatttttt
     6541 gtctttgtcc tccagacaga ttatttccat tttccgatat aatggtatcc agtcctaatg
     6601 gaaagctatt taccaaatcg attagaccag atcctaacat gatatcccaa atttctttat
     6661 ctgagatcgg tcttcctaaa gttatatttt ccctaagcgt accactaaat aatcgatcct
     6721 cctgtaaaac aactccaatt ttttccctaa aactttcaat atcgaattta tctattgggt
     6781 gtttatcaaa aaggatttca ccgctactag gtttataaaa tccagataat aattttaata
     6841 aagttgattt tccagaacca ctctctccta taatagcgat cttctcacct tcttgaatat
     6901 taaacgagat attatccaaa acatctgatg aaaatttact atatcgaaag ctaagattat
     6961 taacttcaat taagccagat aaattctcaa ctctataacc accaaataat aatgcctcta
     7021 ttggcgtttc caaaacatcc aataatctat tcacataaat actaattgaa aaaatttgat
     7081 tatatgagga caaaatcgaa atcaatggag aaataaatga tactccaatt gaaacaaatc
     7141 ctacaatact cccaagtgtt aattccactc ctgcttgatt cagttgaatt cctacaatat
     7201 aaattatcaa agtatataat acttgaacac tatgtgaaaa gttaataaaa atggaactat
     7261 aattggcacg cttaacctca tagtaaagtt gttcttcaaa attatttacc cagtttttaa
     7321 atatgttatc ttttgaagcc gttgatttta tagttaatat attgttaatc atttcgttta
     7381 tattattctg agaattagat aatgcagtta tttcattctg agtcaatttt ttattataaa
     7441 aagaatttat aaacagtgat ccacttatta ataccactat aatcaaggtt acaaaggtta
     7501 atgtagtatt tattaaaaac attgcaatca aatataataa tgcaaaaaca aaattaataa
     7561 ttagttcaat aacttggtca ataagtattt gtcgaatata actatttgag tttaaagtat
     7621 aaactaaatc tcctttatta cgattagtaa aatatgaata tggtaagtcc aataaatgtt
     7681 taacaactgt cgttaccaaa tctctatcaa ttgttgtttg aagtttagct attaacttaa
     7741 ttttaatata attagttcca aaatatagaa aacttattat tattaaagtt aaacctagaa
     7801 ttgaatgatc aagtgctttc cacatcattg gatcatctat tattgaccgg ataatatacg
     7861 gaattgatag tgccaatagc tgaacactga atgaaataac taaaacagaa aaaacaattt
     7921 taaaatgttt gagcaagttt ttaaaatagt aattaaaaat tccaaaggtg tttctttttt
     7981 ttgagtattt tctgtctatg tataaaattg ctttcgaaaa gcattcctta aattcttctt
     8041 cgttcaaaca gaacctgcct aatgccggat caacaatata atatttcttc ctgtcaaccc
     8101 tttcaataat cacaaaatgg ctttccttcc aaaatgcaat acaaggtgta ggaacactcc
     8161 taattctgtc atagtccaca tgaatacatc ttgtactaat gttataatca ctaaatatta
     8221 aggttaattg agcaaaatta tatccaccat ttgggacacc atacttctgt ctcaaatgag
     8281 ttagtctcat attttctgaa aagtaatcaa tcaacattgc tacacatgca agaccgcact
     8341 cagaatgttc actctgttgt tgaaatctaa tcttcaatgt taactcctca ctttaatcta
     8401 tgtgataaat aatcactata tgaatcaaaa cttaacattc ctgtatcttc ccaaaacttc
     8461 aattcgttaa actcccagtc aggaaaacga acggccattt ctttttgttg tagaatatta
     8521 aatttttcag agataaatgc tgtttctaaa aattgatttg agctaggtcg ttgacgagaa
     8581 tattgtttta ttcgctcaga aatttcaata gatacctcag aaagccacaa attattatta
     8641 atctgatttg gaaattcaga agcattcgca tttgcaatta cattccctcc catcgcagtc
     8701 attatctcac ttaggggttc tgtaaccgac ctttcaccgt ttgaaccatt cgtacttaac
     8761 actactacag gtttcccttg caatctcatc gtatgggccc accaggataa tcgatctaat
     8821 atccttttta aatctcctgt catatagtgt aagtaaacgg gagaagcaat gataaaaata
     8881 tcggatgata gaattttatc ttctaatagc gaaatatcat ctcttaaaac acatttagcc
     8941 tgttgaaaac aattatggca accaacacat ggttgaatat ctaaatcttg tggaaaacag
     9001 taatctacat caaaatcact aagattgctg ataattgatt ttacaaacct gtatgtatta
     9061 ccttttttcc tcctgctacc tataagtata aaaatttttt tcacaatata catcccttct
     9121 atttaagtta tattcttgtg atacatctta actagcttca ataaagtaaa tatctataac
     9181 caaaaaaatc tctatctata ctctaatagt cagtttatag gaacacaaca gattgaaact
     9241 aagtaaacct tatatatttt ttataatcta aaatgtttta ccatattaac aattaattct
     9301 agttattcaa ctttttcttt aaaatatggt tatagtgttt atcataataa tcacaatact
     9361 actattatat ttataaaaaa gagaaacagg ttcaaagtac ttctttaacc caatattgaa
     9421 cctgtcccta atttaaaata attaatatta acattttaca gctgaaatta ttgcacctga
     9481 aattgcactt gaaattgcac ttattgcatt agcgcaactt gctgaagaag ctctagctgt
     9541 atagataata ctagcgaaac aggctggtgt agtaggagta aattctgcgc tcatatctcc
     9601 agaaccttga accaaagtca tctctgctat actcatttct tcaaaggaat caccagcgta
     9661 cttatttaca tcaatttcat ttatcatctt ctcctcctaa cacttccctt taagggtttt
     9721 cacaacatct actgaaaact taaaacttac tgccgcacct gatataacat tactaattat
     9781 taacacacaa gctggagtcg tctcaggaga aatatcccca ctcccttgca ctcgagtcat
     9841 ttcagcaatt gacatatcct caaatgctgc cccagttaca attgaatctt gaacatctaa
     9901 cattgttaat cctttccatt ttttagaaaa cacatgtcac agtcaaagtt tatattatta
     9961 aaccatctta accatctcct tttatatgct gtaaacatat ttagaatccg agcatcatta
    10021 tattagaaca tttattttct aaaaacaaat acatccaccc tattcctgca attccatcaa
    10081 atagtccaag agaataagtt tttccaaccc taggaagcag ataggaatca aataaagaat
    10141 tcaattttaa tttatagagt tggtttttca acatatcatt ccattttttt tcaccagtga
    10201 atttataaac taatgataaa gtaataatca ctccggctga accatgacac aaactatcat
    10261 catcaatcga acttaccatt aaactatgtt caaattcttt aaataataca tataaatcct
    10321 tgatattaat ataagatgaa gcattatagt acattgacaa ttttgcttga atgatacctg
    10381 ctaaacccaa acaccactta tatcgatcag ataatttagg taaattatct acttctaaac
    10441 tagaataatt ataagcaaac tcctctaaac cttgatctaa agatctagaa atagccaaac
    10501 cagcaatccc atgcgctaat ccaggtttac tttttaactc cttatctcct tttgatcgtt
    10561 ccatgagtac ttgataaaac attcctattg tagtagacga tatttttaat ggatagacta
    10621 gattaatctg atgcaacaag gtaatcacgc ccgaaattcc agaaatataa tcaatctttt
    10681 ctattttata tacatcctct gaggttagag tatttagttt atcaattgta aatctaaaat
    10741 atttttcatc tacaagtgta gaattatatt tatactctag aaggagcggg aacattgggg
    10801 aaagccaacc aaaaaatggg ctttgaaatg ttgtattacg agtttgtagg attgcagaac
    10861 ttatataccc cttataataa tggaaataga taggttcctt agtcacgtta tatagttcca
    10921 aaaagaatag agctatccca cttaatccac cataaaaact ttcattcatt ggttgaaaac
    10981 tccaatgata ttctctatca ctatcaagat ttaccatgga tatcatctct tcatactttt
    11041 ttgtattatc catcaaatat ttagcaattt gcttagcctc gcgaatgtaa ttaatgctat
    11101 agttttggat ctttctattc gttttttctt ttctaaaact taaatattca tcatataaac
    11161 caagctccat aaatagaata tccttttgtt tatccacaat atcctgtgac aaactagcta
    11221 ttagtttctt atacttatct aacccagact ctaggaagta attctggtat atatttcctt
    11281 gactatctat taaatcttta gaacctatat tattataaaa tatcggtata tctccgaaca
    11341 ataaatcacg gacttcactc ttaacaactc tcttatccaa atatggatac gcccaaatat
    11401 tcataaatag tctctctcta tatttcatcc tcttcccata attaggatga cttgaatatc
    11461 taagcatact cgcatacttc tcagtacctt taagcaatat tctaactttt atatttttaa
    11521 attgttcaac tcttctaagt agttctattt tattctttaa aacaaaatca aaaaaatctt
    11581 caaagccttc tattatctta aatctataat ctttcgaatc tacttcttgt cctttatata
    11641 tcggaatatt gttacctgac gaaaaatata catttttttc cgaatatcta aaatcatcgc
    11701 tattaatatt tatcggggtt gatactgtac tactagtttc acccccctta ccaattagtg
    11761 cacttaattc aattgcccca tccattccaa ctggaatttt tcgtggtaat aaacacgaac
    11821 cttttataga atcatgctcc agctcttgta aaatattatt aaaaatatcg tccggggtta
    11881 ttttagatga taaatgaaac gctgtttcaa tatcaattac tattggatat tcactgcttg
    11941 ctacaacgtt ttccaagtgg agatcatcaa tccccaataa ataacacaac gctattaaat
    12001 aaccaaaccg tatataaaac ctttgtacct cttcaataca attacacggt tttctataca
    12061 cgaactcatt ataagtgtaa ttgttcctgt atagtccttt tggaagatgc agatctaaga
    12121 gctcttcact gctaaaccat tttaataatt ccgatattct ttcttcaatt tttaaatttt
    12181 taggtttata tacaattttc tgaatatgat tcacttcaaa aatgattact gatttaccat
    12241 tttcatgaga atctccagct gctagttcta ggtcagttat cactacttct gataaattaa
    12301 aaaaattttt taaatcatag gtgtcattat tgaggttatt aaaaaaattg ctaatattgt
    12361 ctataaaaaa ttgagtccga actgttaata atctagcagt aacagggtat tcttcaaaaa
    12421 actgaataaa cgactcttta gaatagaact tatcttccaa aaacttttca aacacgccat
    12481 ttctattaga aaaattattt tcctttttat attcagctaa cttcaaggcc ataattttac
    12541 caatcaaatt gaacagctca tcattctgat ataaaattat cttatcgaat atttcttcat
    12601 caaccctaaa attatctaaa ttactaattt tactcttaat attatctaaa gtatatttac
    12661 tgaacggcag ggttaataca cttattccag cctcataatt aatattgtta taatcataat
    12721 tttgtataat aaataaaaac ttatcatacc attctggatt atcggcaaat tcgttacttt
    12781 ctcgtaaaga atttgcaaat tcttccaaag tatacccctc ttcctttaac ataagttcaa
    12841 acaactcgtc tgtcattagt gttctcacat ttctccattc cttaagaaat gtgtaatcaa
    12901 tttcaatatt ttcgttaaaa aacttagact tttctctaat tgtttgtgca ctactaacta
    12961 tataatcatg catttttaac ctcacttaaa aatctatcaa tataataacc cttgatctga
    13021 agcaacagtt ttaaacaatt ccaggtatat tataagtcca ttacatcgac ttaaaaattc
    13081 tcatattaaa taaagtatta tttttaaaaa tatcaatatt tatgtaaaaa atgtgattat
    13141 acatgagaat ccgccttgcc atcaattagt cctaaacgct ctgattcgac aattttacct
    13201 aaatatatct cactagatac attatcattt atattcgaaa cattaatata aatgttacca
    13261 aagttaacta aaagtgaaaa tcctaataaa gtaataaata atttcctcat tttgaaaccc
    13321 ctttcacatc tttcaagtga attatataac attaattttt ataagtcaaa ttattttagg
    13381 ttgttcgcac tattttattt attatatctc attcgagata tttaactgaa catttaaatt
    13441 acttattctt agcggttatt gttttgaatt ttaactttgt ataacactat aactgaattt
    13501 taatctttga caatatatct gttatgagat agaataagtt ctagtaatta atttagcaat
    13561 ttcaatataa aaattcaaac gagatttaat atgcaatcaa taggtaataa aattaaaaca
    13621 aaaagaaagt cactaggact atctcaaaaa gatttggctg atggaatttg cgaacaaagt
    13681 ctaattagta aaatcgaacg aacaaactat tttccttccg ctgatgttct ttataactta
    13741 tcacaaaaac ttcaggtgga tataaattac tttttcgatg agtcgtatga gactgtctct
    13801 gatttacgaa actttattgc catgtcctca aagcttttag aacatagaaa ttacaatgat
    13861 ttagagtatc tttacaacct tgaaaaaagc aatcaaaatt catttaatga ggatgaacaa
    13921 tcttatttaa catggattga agctattata ctcttttaca actatgatca aaaagatagt
    13981 gcaattgagt tacttaaaaa tctcattgac tcttttcttg actataaaaa aaatatttat
    14041 ttaaaagctc tgaatactct aacaaatttc tactcaaata taggctataa cgaggaatat
    14101 gaaaaaaatt acaagcaact tcttcaaatc tattcaacaa aagatttcca attaaaagag
    14161 gatatagaag gatatatccg gttaaaatat aattttgcac atcatttaac gattaacggt
    14221 caattactgg atgctttaga aacagcatta gaaaccatag atttttgtaa aaataataat
    14281 acagcatatc aaatgccttc tctactcctt ctcgttgcta attcttgtga aaaatttcta
    14341 tctaaagaag agattttaca atattacact gatgcaaaaa cactagctaa attatacgga
    14401 aatgatgtgc tctatctcaa aataaaaaat tacctaatca attacaatag tgattgaatt
    14461 ctttttaact aaactgagct tcattatctt aatattttcc aatactaaaa taatagtagc
    14521 attcagatta gtctttaaaa acattataac aaccgttttc ttgtataact aggtgaggta
    14581 cttattcatt cgtttcctcg ggttcactag tttatgatgg atctagaccc tttcgataat
    14641 tgtgtttagg ttccagaaga tactagtaca gaatttgaag ttagcttgtt acagaagtga
    14701 agtaggggtt caatacgaat caatacagaa gaaaaacgct gatttcaagc gttttttctt
    14761 cttgccaaat gcgatatatt gcactgtatt tcaattcaaa ctccaccttt ttctctacct
    14821 tttttcttaa gacctggttt agaaagtatg ggtttcagtt ggactaaaaa caggggaata
    14881 tcaaggtttt tcagaaccat atctactgat taatttccaa tttataaaat tatgctagac
    14941 ggaaaaagcc atctatctat tttttatgac aatctctatt caaaaatgaa gttacccact
    15001 ttataatgat tactattacc tctaaactca taggcaaagc attatctttt gtcctattcc
    15061 acaaagtatt ttctcttatt ttatctagaa aatcatgtcc cgcccaagtc aatgatccta
    15121 cactaaaagc ataaattcta tcatcaccat atgtaggttc ataactatct aggaggcctg
    15181 catcagccag aatttttaca atgatatgct actgtatcaa gatcaaatcc atcaatgttt
    15241 aaattatata gtgctattga tctatactct gtctcaatct taaataaaat caatcgacaa
    15301 tagtttaata tttgctgtta taatagacat ttcttcattt ttccgttata acagacactg
    15361 acatactttt gtaatattat tttggtataa ttaaaataac agaaggaggc aaagattatg
    15421 agaaaaataa taggtatact actactttca ttatcaataa ttacgttaat tgcttgctca
    15481 aaaaacaact accaatcttt agatggtgag tattattgga tatcaagtga aagaaatgaa
    15541 ctggcattta ctataaaagg gaacagaggt tcaatagaac atggagaagc tgataacttt
    15601 acaattgatc aagaaaataa taccttccat ttatcaggag aaggtaccac tgattcaaca
    15661 gtaaaatata aagttaagga tggcaccatt acagtcgata tatctggaat agaacatgaa
    15721 tattaccaaa aaggcagtga agcatataat aaagcacttc aacaatataa taagtagaaa
    15781 tagagcgatg aagttttgat ttcttattta tattaggtta taagaaaaca ccctgaaaga
    15841 tagataggag aatctaactt tcagggtgtt ttcattttta agagcgttga atatgtcttt
    15901 attttgtgag tgagacacgg aaatcattgt atttgctgta atcaaactct tcattgagac
    15961 ctgttacaaa tacaattggt gtataatgtc cctcttccaa aatgaaaccg gcttttacct
    16021 tggcattggc tcccccaagt ccagcaatac ctggaagaag ggcatcaaaa gctccaggtt
    16081 cgtctgtttc ccagtaatag atattaccag aagcttgaac agcttttgct ctagtcgttg
    16141 ctgtacgcat tgggttcaca tctgcttgat aaaagtttgc tgtcgtagtg accgttccgt
    16201 ccgctgccac tgtcatttgg acatctttcg caatttcagt tgtacctgtc caagtcccta
    16261 ccagctctgc aggaaccatt tgagatgaat ctgtagcttt gtcaccactt gttgtattag
    16321 acgctgtggt tgtttgactt gattgtgttg tttcttctga actagattca gtttcttttg
    16381 tatttttctt tttagaagac tgatttgttt tattcttacc agatgtcata gtagtctgtg
    16441 tttcttttac agaagaactg ttctcctctt ttttagaacc acaagctact agtagagttg
    16501 cagaagttaa gcctaaaagt gctaaacttg tccatttttt cataattatg atacctcacc
    16561 taaatttata ttagctatta tattacaaag ttatagaatg tcaagtgttt ttgaaatatt
    16621 tttgtaacat ttgtaattta tctaaatttt taaagggtgg cgcatagggt tacaaagtaa
    16681 aagatttcta tattctttgt tacataatca tcagaaatag aaaatcaacg taaataaaat
    16741 gttgttagag tttcattggt acaaaattcc caacaataat tcctacaatt ctaggatctt
    16801 catcatacga aagaaaaata tctttatagt ttggattgat agaaaccagc cttaagccat
    16861 gctcctctcg ataaactcgt ttaatataag tctggttatt gcagactacg gcataaactg
    16921 ctccatcgta atcaaatcct gtctcacgaa tgagagccac agatccgttc tgatatttgg
    16981 gttccatcga gtcaccagaa atccatgagg cgaaatcatg ggctagttct tcatgaaaat
    17041 aaacagtatc atagttctga tcgttataca ccgatgaacc gataccagcc gacaggcttt
    17101 catagacacg ataagggacg gtaggcatag caataatatt agattgctta tctactaaat
    17161 ctttaacata gttcatagcc ttggtctgat tagtaggatt cagttgctta taaagtgtag
    17221 caatttcttc ctcatagaag aactcttcta tcacacctaa aatctcagaa atctttttca
    17281 agttggcttt gttggggact gctctgccat tttcccaaga gaaataagaa gagcggttaa
    17341 tatcaagaag ccgtgcaatc tcgctttgtt tcatccccaa ctcttcacgt ttttgtttta
    17401 attttgtacc attgaacatc tcatgccctt tctaataata actgtgtttt ggcgttacta
    17461 acggcttgtc tctctgttaa cctatccttt ttccaggcaa agtaaataac tttaccataa
    17521 tcaaaaagtt gaccacaaga aatatctgat ttttcagctt ccaaagtctg tctaaacttt
    17581 ttatctttca attcatagat ttgtcggtct gacagatagc tgtctctggt cagcaaatga
    17641 tagatcttag ccagcatatc tatcatgact tgctggtact ctgctataat agaggacttc
    17701 aacaagctaa acatattcat aattctatct agttgaccat ttttatagtc ttgaattgca
    17761 tgattaacct catctaacga atgagtcgtt tcgtgactga ataagtctct caagcgatag
    17821 accaaggctt cagctgaaac cttcaaatcc ttcatcactc gtgagaaact atcatgccta
    17881 taaaatatct ttgagagcaa aacaatgctt ggcataagca caaatgcaga aaaaagattt
    17941 gcttcgctct caaagataga gcaagactca tcctttagct ctgtaaagaa agagccagta
    18001 tgctttagca gaaaatgccc caactcatgg cactttgtaa agttctgttt tacttgcgga
    18061 ttttcctttt cataggagaa agaaacacca ctctcatcaa ttaaagtcag cccctcaatc
    18121 tttctactgg aaaaatgatg ctccataacc ttgatattgt gaatctcaat cacatgatta
    18181 aagaatcctt caaagtcata acccaaaagg gaagagtcat tctccttgat atacttgtaa
    18241 atatagtgat ttgcaacttc cttaatttgg ctgtatcgtg tatccataat acctcctcga
    18301 ggttgtgttg ttttataaac caacaataat tgtataaaaa aagtggacga ttgtccactg
    18361 gaaactaaga tttaaaaagt ttccataaca agcatttatc ccctttctta ttatacacat
    18421 atcccctatg atacttttta tgtttctttt gtctgtattt tctattactt acaatcacta
    18481 aagatactcg cttcactttt tcttcttcag tatctgtaat atttaccaac tcagtttcat
    18541 taccttcttc aatatctgca acgtttacca attcagtttc actactagct tcttcatcgc
    18601 attggttttg tttttttctt aaaataattg aaattataac caatattatc attagaaaaa
    18661 ggaataccat caaagttaag attaaattaa cccaagcaga tttaaattca cttttctcaa
    18721 aaaagttttc taactgtttt atagggaacc aattattttc aataagaact ttactgatac
    18781 taaatgagat taactccact gtcaataaag ttcttaaaaa agataattct cgcttttttg
    18841 tgattgaact aggatacact tgattaaaaa ttatatacct atcctcagat agataccaca
    18901 tcccaattac gtatattaaa acagaaaaaa ataattcaga aataatcgta tccgatagaa
    18961 taagcaaaag taatatcgag aaaacactaa atgaaacaac taaaccaaca cgactgaaaa
    19021 acttaaattc gtacaccttt tcactgaaac tagcaaacaa aacagttact ccagtttcca
    19081 aaatcttata caacaaaaag ataaggaata ttagtgcgaa tactagaaat atattttttt
    19141 tagaattctc atctattttt actccatagg aaatcatgcg ctccattatc aagcttgaac
    19201 ctataaattc tatgaagtgt aaaatttgaa taaattgttt ccttaaaaat ttaaattcct
    19261 tagaaactgt tttttccgcc ttatcctctt tattgttgag tatcaatact aaaacattgt
    19321 ttaaaatcaa ccaatgtaat ggattataat ctaaaaaatt aagcttctca acaacgaaca
    19381 ctaccaatat cattattaaa gatataatag gaaaaatcgt tcctaagatg gtatgtttta
    19441 ttttggatct ttgagtcatt acttttcccc atcaaaaagt ttcttccgct ccttcataaa
    19501 atgaaggagc tcttgtttaa aaacttcttt ttcttcattg ctcataccgt ctgatgtgct
    19561 tctaaagagc aattctactt ctgacaagtc aatgtcatca ttagttttat ttgataccaa
    19621 ggtatcaact gagatattaa agagtttagc aatcttcacg agattgtcat aactgggccg
    19681 tttttttcct tgttcccaat aagcgtatcc ttgttgcgaa atttcgatag cttttgcgac
    19741 ttgggcttgg gtcattttag cttgttttct caaggtctta aggtgttccg caagatccat
    19801 tatcgttccc cttaaaaaaa tatttttaaa ttttttcaaa aaatcgttga cattcacaac
    19861 ctacagttgt ataatatagt caacaactga tagttgtata gcgattgaaa ataataacct
    19921 tatcttcaag gctaaatcac gatctttgac aattaaataa aaagtgcgtc tgacaaccag
    19981 aggactgact atcaaactac actaaacttc gtacctttat tgtaatctat ttgataggta
    20041 aagtcaagtc cgttttatgg ttgaagtgga gatagaaaac aagattcgat tcttgtgggc
    20101 ttccacgcat ttcggacttt cgcacttttc cgaatagtaa agtgaactgg cttcgccaaa
    20161 gggcgtaaga gaatcccttg ggtatgatca tgactacctg aagagattgg ctgggaaagc
    20221 gatggtaatt gacgcaaagc accttgctaa acgttgccac cgtggaaaga gggatctttc
    20281 caaccaaata acttttcttt actgctgtct atctaattag atagacctac tctcaagcta
    20341 ctaagttctt tccttttttc acttagtagc ttttttactt attacaataa aggagaatga
    20401 tatgacaaac ttttttcgca caacaatgta agcgactcta tgataactat gaatttacct
    20461 atggcatgtt tagtgaatct gataaattac aggctaaact ctatgctcaa gctcaaattg
    20521 atttagacca tctcgcagat gatgctcgta gaaatggcta tgctcatggg gatattcaat
    20581 tctatagtcg catgtttaaa cgcaaattat ttacccacta ttactcaaga gtgaagcaac
    20641 tagcttaact ctttttattt tacactcaga aaggaaatac ttatgatctc agaaacactt
    20701 aaaatgaaac cagaatttat tggccctgct tactacgaac gtttaggaga tgctcctaaa
    20761 tctattttta gaaaagaagg caaataccaa cgtcacattc taaacagcgc agagcacgga
    20821 gcctttcatg tcattacacc agcctctaca acggtcttcc cagaagatgc tctagtagaa
    20881 gcagttaacc caatcttttt cccagatact gctttaaacg gtaatactgt tgcaccttat
    20941 ctcaatgtct ttgcggaaaa attggtactt aaaaaataag aaataaaagg agaaaatcac
    21001 atggctaaaa ttggattaaa ctacggagaa aaactacaaa ttgctgacaa gacttatcgt
    21061 gtcattacag acgggttaga tgtcccagct gtccttggga aactgacttt ccgaggcatt
    21121 gaaggtcctg atatcatctt tgaagtggat cgctcacaac gtaatcctga tggatcattt
    21181 gttcaggtca atactggaga aatccgtggg atcgttgtgg gaattcattc ttctgtccag
    21241 cacgaaacac tctttttcac tatcgcagac atgtcagagt ctgaaattga agacctggga
    21301 attaaatacc gagaagaggt tgagctagaa gatattgtta ttactcatac ccacgtcaat
    21361 cgcaatgata tttataagct ctttgcttct aaaatcaaga aaaaagctgg aggcgcaccg
    21421 tctaaagaaa acaaaccggt agaaaataag aaagaaaact aggaggtgat gcagaatgaa
    21481 actctttacc tatcggggaa aaagagttcg agtttttcat cgtaaactaa agggaatcac
    21541 atggtttatc tggtggtttc cttttttgtt ggctattagt gtctatagct acttacattt
    21601 agaagaatta aaagtccatc ccttacccca aggatatttt ctaggagctg ggcttgttct
    21661 ttctttgctt cttgcttggt ttatcaatcg agtttgctac agaaagttgc tcttttttca
    21721 aaaactcaac agccttcgaa ttctttctcg ctttttgcta gagaataacc tctatctcgt
    21781 taaaaaggtt agacgtgaaa acaagataat tgaaaagatc accttacctc aagtgtatat
    21841 caaacagtct cgctacaaga ttgaagcgag tttcattcta gaaggtaata aatttcaaga
    21901 tcgctttctc aaccttggag ccactcttga agtcatgttt aacggggact ttcgtaataa
    21961 aacctttgat aatcgcttta tcaagtatga aattgctatt aaccgaattg atagcagaat
    22021 caccattgat gaagtaaagg tcaagggatc caaactccag ctcatgaaag atgtatcttg
    22081 ggattatatt gaagaacctc atcttctcat tggcggtgga accggtggag gtaaaaccgt
    22141 tgttctcatg actataatct atgcactagc taaagttggc tttgtcgata tctgtgatcc
    22201 aaagaattca gatctagctg gattaaagaa aattccagtc ttccatggcc gagtttatac
    22261 tagtaaggaa gatatcatta actgttttaa agagaatgta gagttcatgg aaaaacgcta
    22321 tgaactaatg tctacttcgc caaaattcca agctggaaag aactttactc attatgacat
    22381 gaaaccaaaa ttcattctag tagacgagtg ggcagctctt atggccaaaa ttgaccgtga
    22441 ctatagccaa cagtctgaac tcatggaata tctctcacag ttagttctag aaggccgtca
    22501 agctggagtc tttatcatct ttgctatgca acggcccgat ggagaattta tcaaaacggc
    22561 tcttcgggac aactttatga agcgcctctc cgtcggtcat ttagaatcaa caggatatga
    22621 catgatgttt ggagatgcca ataaaaccaa agagttcaaa aagctagatg aaattaatgg
    22681 agtcaaggtc aaagggcggg gctatatcgc aaacaacggc gagctggccg gtgagttttt
    22741 ctctccttat gtaccgctcg atcaaggatt ttccttctat gatgcctact ctaacattcc
    22801 gatcatggag tttgaaggag aagaattctc agtatttgaa gaatataaac caccgattga
    22861 atcaattgat cctatagagg aagaagggac tacagaaaac gaatcaaata aacgaccact
    22921 caaggaattt gcggacgaac aaaatcttaa aatgccaacc ttacgcaaga tta
//
