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Overview
1.1
3.1
4.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_QSIO01000001.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS | 892,653 | 933,825 |

NZ_QSIO01000002.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | terpene-precursor | 310,654 | 331,529 |

NZ_QSIO01000003.1 (Streptococcus parasanguinis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 34,588 | 57,560 | Medium | carnolysin A1/carnolysin A2 | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS | 892,653 | 933,825 |
Region 3.1 | terpene-precursor | 310,654 | 331,529 |
Region 4.1 | lanthipeptide-class-ii | 34,588 | 57,560 | Medium | carnolysin A1/carnolysin A2 | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_QSIO01000010.1 (Streptococcus parasanguinis)
  NZ_QSIO01000004.1 (Streptococcus parasanguinis)
  NZ_QSIO01000005.1 (Streptococcus parasanguinis)
  NZ_QSIO01000006.1 (Streptococcus parasanguinis)
  NZ_QSIO01000007.1 (Streptococcus parasanguinis)
  NZ_QSIO01000008.1 (Streptococcus parasanguinis)
  NZ_QSIO01000009.1 (Streptococcus parasanguinis)

Compact view
NZ_QSIO01000001.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 892,653 - 933,825 nt. (total: 41,173 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
DW820_RS04540: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: hydrolase
DW820_RS04585: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: synthase
DW820_RS04535: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000286.3 |  | 0.41 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002703.2 |  | 0.39 | ribosomal | archalan α | Halorussus salinus
BGC0000934.4 |  | 0.39 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.5 |  | 0.39 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0000255.5 |  | 0.36 | PKS | pederin | Uncultured bacterium
BGC0001606.3 |  | 0.35 | PKS | gibepyrone-A | Fusarium fujikuroi IMI 58289

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002561.3 |  | 0.45 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000286.3 |  | 0.41 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002703.2 |  | 0.39 | ribosomal | archalan α | Halorussus salinus
BGC0000934.4 |  | 0.39 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.5 |  | 0.39 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0000255.5 |  | 0.36 | PKS | pederin | Uncultured bacterium
BGC0001606.3 |  | 0.35 | PKS | gibepyrone-A | Fusarium fujikuroi IMI 58289

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.04 out of 29.25
Confidence: medium
Additional weak hits (12):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.48 out of 26.06
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.05 out of 30.97
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.67 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.14 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.84 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.48 out of 26.06
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_QSIO01000002.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 310,654 - 331,529 nt. (total: 20,876 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
DW820_RS06665: hydrolase

smcogs
  SMCOG1179: hydrolase

Isomerases: mutase
DW820_RS06575: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: synthetase
DW820_RS06615: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Translocases: transporter
DW820_RS06650: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000800.5 |  | 0.37 | saccharide | xanthan | Xanthomonas campestris
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.34 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000800.5 |  | 0.37 | saccharide | xanthan | Xanthomonas campestris
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.34 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
DW820_RS06615: PT_FPPS_like
Domain 1 (27 - 271): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.72 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.60 out of 28.19
Confidence: medium
Additional weak hits (5):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.95 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.92 out of 30.12
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ColR | Phenol-responsive regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_QSIO01000003.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 34,588 - 57,560 nt. (total: 22,973 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
DW820_RS07270: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
DW820_RS07300: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.62 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.62 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000517.4 |  | 0.49 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.62 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.62 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000517.4 |  | 0.49 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for DW820_RS07300

DW820_RS07290
Leader:
MINEIDVNKYAGDSFEEMSIAEMTLVQGS
Core:
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
Core with dehydrations:
G D M Dha A E F Dhb P Dhb Dhb P A Cys F A Dha I I Y Dhb A R A Dha Dha A Dha Cys A N A I Dha A I Dha Dha A I Dha G A I I Dha A V K Cys

#### antiSMASH-DB 4.0 matches for DW820_RS07290

100.0%
NZ_QSIO01000003.1:
Lanthipeptides: DW820_RS07290_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
86.0%
NZ_JAQCQD010000003.1:
Lanthipeptides: PGZ38_RS05485_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D M S A E T P T T P A C F A S I I Y T A R A S S +C A+A+S I S S A I S G A+I S A V K C
1
G D M S A E L T P T T P A C F A S I I Y T A R A S S P N C A H A L S V I S S A I S G A V I S A V K C
50
82.0%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04080_lanthipeptide
Lanthipeptides: JXW96_RS06960_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D M S A E T P T T P A C+A S I I Y T A+A S S +C A A +A I S A I S G A I I S A V K C
1
G D M S A E L T P T T P A C Y A S I I Y T A K A S S P N C A Y A A T A I S G A I S G A I I S A V K C
50
with 45 more sequence matches
Only the first 10 are displayed here.
52.0%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06835_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D+S E F T T+P A C + +R A S S C A A I+S +S A++S A V K C
1
G D V S G E F T-T S P A C V Y V S V A A S R A S S Q K C G Q A S G A I A S F V S T A V L S A V K C
49
52.0%
NZ_QICS01000003.1:
Lanthipeptides: C8E03_RS08695_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D+ A E F T T+P A C A + +A S S A C A A + ++S +S G A+ S A+K C
1
G D V G A E F T-T S P A C V A L S V A A T Q A S S A R C A I A S A G V A S L V S G A V H S A L K C
49
48.0%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide
Lanthipeptides: IV75_RS14640_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D++ E F T T+P A C S++ ++A S S A C A S A+S A I+S A++C
1
G D I N G E F T-T S P A C V Y S V M V V S K A S S A K C A A G A S A V S G----A I L S A I R C
45
46.0%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14440_lanthipeptide
Lanthipeptides: NW963_RS14080_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D M+ E F T T+P A C S ++ +R A S S +C + +A G A++S A+K C
1
G D M N G E F T-T S P A C V Y S A V F A S R A S S K A C I G G L----T A A G G A V L S A L K C
45
46.0%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12705_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D+ E T T P A C S+ T A S S C A A G A+I S V K C
1
G D V Q V E---T T P A C L Y S V Y V T A N V S S V W C A G-------A T V G A V I S I V K C
40
44.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00025_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D++ E T T P C A++ A S S A C A A +S A+S G ++S K C
1
G D I T P E---T T P V C A A T V-----A S S A Y C A G A----A S A V S G I V L S V F K C
38
42.0%
NZ_CP086395.1 and 1 other:
NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11180_lanthipeptide
Lanthipeptides: LMK00_RS10665_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D+ A T+P A C S I T + S S C A A G A+I S V+C
1
G D V Q A R---T S P A C L Y S I A V T I K T S S V W C A G-------A S V G A V I S I V R C
40
40.0%
NZ_JAFLVY010000007.1:
Lanthipeptides: JZO73_RS03905_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
G D++ E F T T+P A C S++ T + S S C A A G A++S +C
1
G D V N G E F T-T S P A C L Y S V M V T L K T S S V P C A G-------A S V G A V V S I A R C
42
39.2%
NZ_CP091282.1:
Lanthipeptides: L2Z53_RS12185_lanthipeptide
1
G D M S A E F T P T T P A C F A S I I Y T A R A--S S A S C A N A I S A I S S A I S G A I I S A V K
49
G D++A E T P+ S Y A A S S A C A + + +G A I+S+ K
1
G D V N A E T T P S L--I M T S P Y Y Q A A A T V S S A G C A T G V G G L I G V G A G A I L S S T K
49
38.0%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
2
D M S A E F T P T T P A C F A S I I Y T A R A S S A S C A N A I S A I S S A I S G A I I S A V K C
50
D+ T P A+I+ S S C I S A I S A I S G I C
2
D V E P R G T P------A T I V S A V T R S S K P C---I S A I G S A I S G I I S H N K D C
41

#### MIBiG 4.0 matches for DW820_RS07290

12.0%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
11
T P A C F A S I I Y T A R A S S A S C A N A I
33
T P C + +A+C +I
8
T P G C K T G A L M G C N M K T A T C H C S I
30
8.0%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
8
T P T T P A
13
T P T P
2
T P A T P T
7
DW820_RS07295
Leader:
MLDVQDSIVTGAAFEDMSIAEMTRVQGS
Core:
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
Core with dehydrations:
G D I Dha P E Dhb Dhb P A Cys V L I I Dha N V I Dha G A A V Dha F K F Dha V D V V K Dhb L K G K Cys

#### antiSMASH-DB 4.0 matches for DW820_RS07295

100.0%
NZ_QSIO01000003.1:
Lanthipeptides: DW820_RS07295_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
87.5%
NZ_JAQCQD010000003.1:
Lanthipeptides: PGZ38_RS05480_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D I S P E T T P A C L I I S +I S G A A V S F F S V V V K T L K G K C
1
G D I S P E T T P A C A L I I S K I I S G A A V S F G F S V S V V K T L K G K C
40
82.5%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide
Lanthipeptides: JXW96_RS06965_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D I S P E T T P A C L I I S I S G A A V S F F S V V V K T+K G C
1
G D I S P E T T P A C A L I I S K A I S G A A V S F A F S V G V V K T V K G N C
40
with 110 more sequence matches
Only the first 10 are displayed here.
45.2%
NZ_CP010976.1:
Lanthipeptides: UB51_RS20985_lanthipeptide
1
G D I S P E T T P A--C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D++P E T T P A ++I+S + A A S S+ V+T+K G C
1
G D V N P E T T P A T P T I V I V S E G L L T A A G S A A L S I L S V R T I K G H C
42
45.0%
NZ_JADMPO010000001.1:
Lanthipeptides: I2I27_RS01390_lanthipeptide
1
G D I S P E-T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D+ E T T P C + A V+ S+ V K T L K G K C
1
G D V E G E V T T P I C A V---------A V T A S L S I Q V A K T L K G K C
32
42.5%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide
Lanthipeptides: NW963_RS14100_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D++P E+T C A S F S+ +V K T L K K C
1
G D V T P E S T T V C---------A A F A S F A G S I Q L V K T L K S K C
31
42.5%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06840_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D I P + + + S V+ A A + F S+ V K T+K G K C
1
G D I E P N S----L T V A S A V L M S A A A T G S F S I A V T K T V K G K C
36
42.5%
NZ_QICS01000003.1:
Lanthipeptides: C8E03_RS08700_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D++ E T T + ++ + A A S+ V V V K T+K G K C
1
G D V N A E T T I E L F I S V T L A A T A A A G S Y A S G V Q V V K T I K G K C
40
42.5%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12700_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D+ E T T P A C S ++ S V V K T+K G C
1
G D V Q V E T T P A C A F T A S I L V---------S Y G V V K T I K G H C
31
40.0%
NZ_CP091282.1:
Lanthipeptides: L2Z53_RS12190_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D++ E T T P I S + ++ S+ V K T+K G K C
1
G D V N V E T T P T A T--I S A F L L S V G G G Y E L S I H V A K T V K G K C
38
40.0%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12935_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D+ E T T P A + + + V+ G ++ F+ +V V K T G C
1
G D V D A E T T P A-I T V S A A V V I G G S L G F E A T V K V T K T C N G N C
39
37.5%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F
28
G D+ E T T P A C I V G A S K F
1
G D V Q A E T T P A C F T I G L G V--G A L F S A K F
26
37.5%
NZ_CP086395.1 and 1 other:
NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide
Lanthipeptides: LMK00_RS10670_lanthipeptide
1
G D I S P E T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
G D+ +T P C +G V S + +V K T L K G+C
1
G D V E V R S T P I C T F T-----A G V T V S----I V I V K T L K G R C
31
allorf_035930_036094
Leader:
MLAIGIEKICFEGARRRMMLVTYS
Core:
F C L V S F F D R I G T I F D R L V K S P C R R W G S L L S
Core with dehydrations:
F Cys L V Dha F F D R I G Dhb I F D R L V K Dha P Cys R R W G Dha L L Dha

#### antiSMASH-DB 4.0 matches for allorf_035930_036094

100.0%
NZ_QSIO01000003.1:
Lanthipeptides: allorf_035930_036094_lanthipeptide
1
F C L V S F F D R I G T I F D R L V K S P C R R W G S L L S
30
F C L V S F F D R I G T I F D R L V K S P C R R W G S L L S
1
F C L V S F F D R I G T I F D R L V K S P C R R W G S L L S
30
16.7%
NZ_LMSL01000013.1:
Lanthipeptides: allorf_00156_00260_lanthipeptide
8
D R I G T I F D R L V K S P C R
23
+R I G + + +P C+
4
N R I G G L D E T T A G A P C K
19
14.0%
NC_017941.2:
Lanthipeptides: allorf_0828594_0828770_lanthipeptide
18
V K S P C R R W G
26
V K+ C R R+G
1
V K T G C R R Y G
9
with 2 more sequence matches
12.0%
NZ_JALPRT010000019.1 and 2 others:
NZ_KB892552.1 Lanthipeptides: allorf_24609_24818_lanthipeptide NZ_KB896162.1 Lanthipeptides: allorf_034118_034327_lanthipeptide
Lanthipeptides: allorf_071360_071569_lanthipeptide
10
I G T I F D R L V K S P
21
+ T+ D R L +S P
9
V H T L V D R L T Q S P
20
11.5%
NZ_QTVL01000002.1 and 2 others:
NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14275_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS03000_lanthipeptide
Lanthipeptides: DWZ44_RS04090_lanthipeptide
8
D R I G T I F D R L V K S P C R R
24
++I + F +K S C R R
9
N Q I L S Y F Q P F I K S E C R R
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.08 out of 26.85
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.95 out of 26.06
Confidence: medium
Additional weak hits (7):
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.62 out of 18.46
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.35 out of 31.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.96 out of 30.22
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.04 out of 20.47
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.10 out of 20.47
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.73 out of 32.74
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

DW820_RS07290 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 4631.3 Da
  Molecular weight: 4634.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4652.3 Da N = 1
    4670.3 Da N = 2
    4688.3 Da N = 3
    4706.3 Da N = 4
    4724.3 Da N = 5
    4742.4 Da N = 6
    4760.4 Da N = 7
    4778.4 Da N = 8
    4796.4 Da N = 9
    4814.4 Da N = 10
    4832.5 Da N = 11
DW820_RS07295 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 3949.2 Da
  Molecular weight: 3951.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3969.6 Da N = 1
    3987.7 Da N = 2
    4005.7 Da N = 3
    4023.7 Da N = 4
    4041.7 Da N = 5
    4059.7 Da N = 6
allorf_035930_036094 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 3427.8 Da
  Molecular weight: 3430.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3448.1 Da N = 1
    3466.1 Da N = 2
    3484.1 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
MogR | Repressor of flagellar motility genes
RutR | Regulator of the pyrimidine and purine metabolism