Select genomic region:
Overview
1.1
1.2
10.1
12.1
37.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_QSHK01000001.1 (Dorea formicigenerans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 106,343 | 127,245 |
Region 1.2 | ranthipeptide | 592,796 | 614,458 |

NZ_QSHK01000018.1 (Dorea formicigenerans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | cyclic-lactone-autoinducer | 8,891 | 29,481 |

NZ_QSHK01000002.1 (Dorea formicigenerans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | cyclic-lactone-autoinducer,lanthipeptide-class-i | 198,378 | 230,440 | Medium | nisin O | ribosomal:RiPP:Lanthipeptide

NZ_QSHK01000008.1 (Dorea formicigenerans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 37.1 | t3nrps-iterative | 101,805 | 139,798 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 106,343 | 127,245 |
Region 1.2 | ranthipeptide | 592,796 | 614,458 |
Region 10.1 | cyclic-lactone-autoinducer | 8,891 | 29,481 |
Region 12.1 | cyclic-lactone-autoinducer,lanthipeptide-class-i | 198,378 | 230,440 | Medium | nisin O | ribosomal:RiPP:Lanthipeptide
Region 37.1 | t3nrps-iterative | 101,805 | 139,798 |

No secondary metabolite regions were found in these records:
  NZ_QSHK01000010.1 (Dorea formicigenerans)
  NZ_QSHK01000011.1 (Dorea formicigenerans)
  NZ_QSHK01000012.1 (Dorea formicigenerans)
  NZ_QSHK01000013.1 (Dorea formicigenerans)
  NZ_QSHK01000014.1 (Dorea formicigenerans)
  NZ_QSHK01000015.1 (Dorea formicigenerans)
  NZ_QSHK01000016.1 (Dorea formicigenerans)
  NZ_QSHK01000017.1 (Dorea formicigenerans)
  NZ_QSHK01000019.1 (Dorea formicigenerans)
  NZ_QSHK01000020.1 (Dorea formicigenerans)
  NZ_QSHK01000021.1 (Dorea formicigenerans)
  NZ_QSHK01000022.1 (Dorea formicigenerans)
  NZ_QSHK01000023.1 (Dorea formicigenerans)
  NZ_QSHK01000024.1 (Dorea formicigenerans)
  NZ_QSHK01000025.1 (Dorea formicigenerans)
  NZ_QSHK01000026.1 (Dorea formicigenerans)
  NZ_QSHK01000027.1 (Dorea formicigenerans)
  NZ_QSHK01000028.1 (Dorea formicigenerans)
  NZ_QSHK01000029.1 (Dorea formicigenerans)
  NZ_QSHK01000003.1 (Dorea formicigenerans)
  NZ_QSHK01000030.1 (Dorea formicigenerans)
  NZ_QSHK01000031.1 (Dorea formicigenerans)
  NZ_QSHK01000032.1 (Dorea formicigenerans)
  NZ_QSHK01000033.1 (Dorea formicigenerans)
  NZ_QSHK01000034.1 (Dorea formicigenerans)
  NZ_QSHK01000035.1 (Dorea formicigenerans)
  NZ_QSHK01000036.1 (Dorea formicigenerans)
  NZ_QSHK01000037.1 (Dorea formicigenerans)
  NZ_QSHK01000038.1 (Dorea formicigenerans)
  NZ_QSHK01000004.1 (Dorea formicigenerans)
  NZ_QSHK01000005.1 (Dorea formicigenerans)
  NZ_QSHK01000006.1 (Dorea formicigenerans)
  NZ_QSHK01000007.1 (Dorea formicigenerans)
  NZ_QSHK01000009.1 (Dorea formicigenerans)

Compact view
NZ_QSHK01000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 106,343 - 127,245 nt. (total: 20,903 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
DW860_RS00625: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase
DW860_RS00560: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase
DW860_RS00585: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

DW860_RS00590: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001604.3 |  | 0.37 | terpene | gibberellin | Fusarium fujikuroi
BGC0001227.3 |  | 0.36 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000663.5 |  | 0.36 | terpene | hopene | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001604.3 |  | 0.37 | terpene | gibberellin | Fusarium fujikuroi
BGC0001227.3 |  | 0.36 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000663.5 |  | 0.36 | terpene | hopene | Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
DW860_RS00585: PT_FPPS_like
Domain 1 (36 - 299): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.66 out of 23.79
Confidence: medium
Additional weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.72 out of 30.98
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
ToxT | Regulator of MSHA biosynthesis

NZ_QSHK01000001.1 - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 592,796 - 614,458 nt. (total: 21,663 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: transferase
DW860_RS02940: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

DW860_RS02945: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase
DW860_RS02870: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001387.5 |  | 0.37 | other (other) | nucleocidin | Streptomyces calvus
BGC0001995.3 |  | 0.37 | terpene | heptelidic acid | Aspergillus oryzae RIB40
BGC0000678.5 |  | 0.36 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002436.2 |  | 0.34 | other (other) | coformycin | Streptomyces citricolor
BGC0001002.5 |  | 0.34 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0001591.4 |  | 0.33 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001607.5 |  | 0.33 | other (other) | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000653.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces arenae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001387.5 |  | 0.37 | other (other) | nucleocidin | Streptomyces calvus
BGC0001995.3 |  | 0.37 | terpene | heptelidic acid | Aspergillus oryzae RIB40
BGC0000678.5 |  | 0.36 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002436.2 |  | 0.34 | other (other) | coformycin | Streptomyces citricolor
BGC0001002.5 |  | 0.34 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0001591.4 |  | 0.33 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001607.5 |  | 0.33 | other (other) | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000653.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces arenae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.07 out of 18.46
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 20.47
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.55 out of 21.55
Confidence: strong
Additional weak hits (1):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (592795...614458)
DW860_RS02895
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 0 - 111
  Score: 102.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
VqsM | Regulator of quorum-sensing signalling systems

NZ_QSHK01000018.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,891 - 29,481 nt. (total: 20,591 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000158.5 |  | 0.19 | PKS | tautomycetin | Streptomyces griseochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000158.5 |  | 0.19 | PKS | tautomycetin | Streptomyces griseochromogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.83 out of 26.33
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14
Confidence: medium
Additional weak hits (2):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
PerR | Peroxide regulator

NZ_QSHK01000002.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 198,378 - 230,440 nt. (total: 32,063 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
DW860_RS04695: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

DW860_RS04705: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001701.4 |  |  | 0.61 | ribosomal | nisin O | Blautia obeum
BGC0000538.3 |  |  | 0.47 | ribosomal | nisin Z | Lactococcus lactis
BGC0001289.5 |  |  | 0.43 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002328.3 |  |  | 0.37 | ribosomal | Rc-AIP1 | Ruminiclostridium cellulolyticum H10
BGC0000515.4 |  |  | 0.34 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000542.3 |  |  | 0.34 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  |  | 0.34 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000506.4 |  |  | 0.34 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  |  | 0.31 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002668.2 |  |  | 0.31 | ribosomal | cesin A | Clostridium estertheticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001701.4 |  | 0.80 | ribosomal | nisin O | Blautia obeum
BGC0000538.3 |  | 0.65 | ribosomal | nisin Z | Lactococcus lactis
BGC0001289.5 |  | 0.59 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000515.4 |  | 0.57 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000542.3 |  | 0.56 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000506.4 |  | 0.56 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000541.5 |  | 0.56 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0002668.2 |  | 0.55 | ribosomal | cesin A | Clostridium estertheticum
BGC0000559.4 |  | 0.54 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000535.4 |  | 0.53 | ribosomal | nisin A | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for DW860_RS04705

DW860_RS04730
Leader:
MAKFDDFDLDVTKTAAQGGIEPK
DW860_RS04735
Leader:
MAKFDDFDLDVTKTAAQGGIEPK
Shared core:
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
Core with dehydrations:
Y K Dha K Dha V Cys Dhb P G Cys P Dhb G I L M Dhb Cys P L K Dhb A Dhb Cys G Cys H I Dhb G K

#### antiSMASH-DB 4.0 matches for DW860_RS04730

100.0%
NZ_QSHK01000002.1 and 1 other:
NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide
Lanthipeptides: DW860_RS04735_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
97.0%
NZ_JADNJR010000016.1 and 2 others:
NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptide NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide
Lanthipeptides: I2E58_RS10880_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
Y K S K S C T P G C P T G I L M T C P L K T A T C G C H I T G K
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
78.8%
NZ_CP015405.2 and 7 others:
NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide
Lanthipeptides: A4V09_RS08300_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
S K S+C T P G C T G I L M T C P++T A T C G C I T G K
3
S K S L C T P G C V T G I L M T C P V Q T A T C G C Q I T G K
33
with 80 more sequence matches
Only the first 10 are displayed here.
69.7%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I
30
S K S+C T P G C T G I L M T C +K T A T C G C H
3
S K S L C T P G C K T G I L M T C A I K T A T C G C H F
30
69.7%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I
30
S K S+C T P G C T G L M T C P+K T A T C G C H
3
S K S L C T P G C K T G A L M T C P I K T A T C G C H F
30
69.7%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
3
S K S V C T P-G C P T G I L M T C P L K T A T C G C H I
30
S K S+C T P G C T G I L M T C +K T A T C G C H
3
S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
66.7%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I
30
S S+C T P G C T G I L M T C +K T A T C G C H
3
S I S L C T P G C K T G I L M T C A I K T A T C G C H F
30
63.6%
NZ_BMMB01000002.1:
Lanthipeptides: IEX62_RS05935_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S K S C T P G C T G+L T C ++T A T C C H I+
1
W K S K S F C T P G C V T G V L Q T C F I Q T A T C N C H I S
31
63.6%
NZ_CP025079.1 and 3 others:
NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide
Lanthipeptides: BVQ_RS17705_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S+S V C T P G C T G+L T C L+T T C C H I+
1
W K S E S V C T P G C V T G V L Q T C F L Q T I T C N C H I S
31
60.6%
NC_016047.1 and 2 others:
NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S+S V C T P G C T G+L T C L+T T C C I+
1
W K S E S V C T P G C V T G L L Q T C F L Q T I T C N C K I S
31
60.6%
NZ_CP117416.1 and 1 other:
NZ_JAQQZQ010000001.1 Lanthipeptides: PO903_RS06885_lanthipeptide
Lanthipeptides: PQ456_RS01230_lanthipeptide
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S+S C T P G C T G+L T C ++T A T C C H I+
1
W K S Q S F C T P G C V T G V L Q T C F I Q T A T C N C H I S
31
60.0%
NZ_NHVL01000013.1:
Lanthipeptides: CEU70_RS16830_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C--H I T G K
33
S K S+C T P G C T G I L T C +K+A T C G C H I G K
5
S K S L C T P G C K T G I L Q T C A I K S A T C G C S I H I G G K
37
58.8%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I
30
S S+C T P G C T G+L M C L K T A T C C I
3
S Y S L C T P G C K T G V L M A C H L K T A T C N C S I
30

#### MIBiG 4.0 matches for DW860_RS04730

55.9%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
3
S K S V C T P G C P T G I L M T C P L K T A T C G C H I
30
S S+C T P G C T G L M C +K T A T C C I
3
S I S L C T P G C K T G A L M G C N M K T A T C H C S I
30
12.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
8
T P G C P T
13
T P P T
2
T P A T P T
7
DW860_RS04740
Leader:
MAKFDDFDLDVTKTAARGGIEPK
Core:
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
Core with dehydrations:
Y K Dha K Dha A Cys Dhb P G Cys P Dhb G I L M Dhb Cys P L K Dhb A Dhb Cys G Cys H I Dhb G K

#### antiSMASH-DB 4.0 matches for DW860_RS04740

100.0%
NZ_JADNJR010000016.1 and 2 others:
NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptide NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide
Lanthipeptides: I2E58_RS10880_lanthipeptide
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
97.0%
NZ_QSHK01000002.1 and 1 other:
NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide
Lanthipeptides: DW860_RS04735_lanthipeptide
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
Y K S K S C T P G C P T G I L M T C P L K T A T C G C H I T G K
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
78.8%
NZ_CP015405.2 and 7 others:
NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide
Lanthipeptides: A4V09_RS08300_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I T G K
33
S K S C T P G C T G I L M T C P++T A T C G C I T G K
3
S K S L C T P G C V T G I L M T C P V Q T A T C G C Q I T G K
33
with 71 more sequence matches
Only the first 10 are displayed here.
69.7%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S K S C T P G C T G I L M T C +K T A T C G C H
3
S K S L C T P G C K T G I L M T C A I K T A T C G C H F
30
69.7%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S K S C T P G C T G L M T C P+K T A T C G C H
3
S K S L C T P G C K T G A L M T C P I K T A T C G C H F
30
69.7%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
3
S K S A C T P-G C P T G I L M T C P L K T A T C G C H I
30
S K S C T P G C T G I L M T C +K T A T C G C H
3
S K S L C T P P G C K T G I L M T C A I K T A T C G C H F
31
66.7%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S S C T P G C T G I L M T C +K T A T C G C H
3
S I S L C T P G C K T G I L M T C A I K T A T C G C H F
30
63.6%
NZ_BMMB01000002.1:
Lanthipeptides: IEX62_RS05935_lanthipeptide
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S K S C T P G C T G+L T C ++T A T C C H I+
1
W K S K S F C T P G C V T G V L Q T C F I Q T A T C N C H I S
31
60.6%
NZ_CP025079.1 and 3 others:
NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide
Lanthipeptides: BVQ_RS17705_lanthipeptide
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S+S C T P G C T G+L T C L+T T C C H I+
1
W K S E S V C T P G C V T G V L Q T C F L Q T I T C N C H I S
31
60.6%
NZ_CP117416.1 and 1 other:
NZ_JAQQZQ010000001.1 Lanthipeptides: PO903_RS06885_lanthipeptide
Lanthipeptides: PQ456_RS01230_lanthipeptide
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T
31
+K S+S C T P G C T G+L T C ++T A T C C H I+
1
W K S Q S F C T P G C V T G V L Q T C F I Q T A T C N C H I S
31
60.0%
NZ_NHVL01000013.1:
Lanthipeptides: CEU70_RS16830_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C--H I T G K
33
S K S C T P G C T G I L T C +K+A T C G C H I G K
5
S K S L C T P G C K T G I L Q T C A I K S A T C G C S I H I G G K
37
58.8%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S S C T P G C T G+L M C L K T A T C C I
3
S Y S L C T P G C K T G V L M A C H L K T A T C N C S I
30
58.3%
NZ_NHVL01000013.1:
Lanthipeptides: CEU70_RS16825_lanthipeptide
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S K S C T P G C T G I L T C +K+A T C G C I
5
S K S L C T P G C K T G I L Q T C A I K S A T C G C S I
32

#### MIBiG 4.0 matches for DW860_RS04740

55.9%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
3
S K S A C T P G C P T G I L M T C P L K T A T C G C H I
30
S S C T P G C T G L M C +K T A T C C I
3
S I S L C T P G C K T G A L M G C N M K T A T C H C S I
30
12.1%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
8
T P G C P T
13
T P P T
2
T P A T P T
7

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.15 out of 27.78
Confidence: medium
Additional weak hits (1):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

DW860_RS04730 - Class I
  Cleavage pHMM score: 12.50
  RODEO score: 26
  Monoisotopic mass: 3254.6 Da
  Molecular weight: 3256.9 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3275.0 Da N = 1
    3293.0 Da N = 2
    3311.0 Da N = 3
DW860_RS04735 - Class I
  Cleavage pHMM score: 12.50
  RODEO score: 26
  Monoisotopic mass: 3254.6 Da
  Molecular weight: 3256.9 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3275.0 Da N = 1
    3293.0 Da N = 2
    3311.0 Da N = 3
DW860_RS04740 - Class I
  Cleavage pHMM score: 9.70
  RODEO score: 26
  Monoisotopic mass: 3226.6 Da
  Molecular weight: 3228.9 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3246.9 Da N = 1
    3264.9 Da N = 2
    3282.9 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (204258...230440)
DW860_RS04705
  RRE type: Lanthipeptide_LanB_RRE
  Location: 142 - 228
  Score: 45.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_QSHK01000008.1 - Region 1 - t3nrps-iterative
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 101,805 - 139,798 nt. (total: 37,994 nt) Show pHMM detection rules used
Region on contig edge.
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: decarboxylase
DW860_RS11665: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase synthase
DW860_RS11660: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

DW860_RS11705: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | t3nrps-iterative | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.59 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.59 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  | 0.58 | NRPS | peramine | Epichloe festucae
BGC0001825.4 |  | 0.58 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001844.4 |  | 0.44 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.60 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.59 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.59 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  | 0.58 | NRPS | peramine | Epichloe festucae
BGC0001825.4 |  | 0.58 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001844.4 |  | 0.44 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.06 out of 27.78
Confidence: medium
Additional weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.43 out of 29.38
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.00 out of 24.78
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
DW860_RS11660: X
AMP-binding (9..413): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FEFAFDVSVKDSWAIFSGEVNVYGPTEITCNCTY
  Nearest Stachelhaus code(s):
    Ser DVNEISVIEK (35% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria