LOCUS       NZ_CP031749            25239 bp    DNA     circular CON 06-NOV-2024
DEFINITION  Bacillus sp. E25 chromosome.
ACCESSION   NZ_CP031749
VERSION     NZ_CP031749.1
KEYWORDS    RefSeq.
SOURCE      Bacillus sp. E25
  ORGANISM  Bacillus sp. E25
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus.
REFERENCE   1  (bases 1 to 5915788)
  AUTHORS   Equihua,A., Hernandez-Salmeron,J.E. and Santoyo,G.
  TITLE     Draft genome sequence of an endophytic bacterial strain isolated
            from tomato plants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5915788)
  AUTHORS   Equihua,A., Hernandez-Salmeron,J.E. and Santoyo,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-AUG-2018) IIQB, Unversidad Michoacana de San Nicolas
            de Hidalgo, Santiago Tapia, Morelia, Michoacan 58000, Mexico
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-MAY-2018
            Assembly Method                   :: SPAdes v. 3.10.0
            Assembly Name                     :: Bacillus sp. E25
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: Bacillus sp. E25
            Genome Coverage                   :: 358.587x
            Sequencing Technology             :: PacBio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003429225.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 01:21:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,042
            CDSs (total)                      :: 5,949
            Genes (coding)                    :: 5,722
            CDSs (with protein)               :: 5,722
            Genes (RNA)                       :: 93
            rRNAs                             :: 10, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 227
            CDSs (without protein)            :: 227
            Pseudo Genes (ambiguous residues) :: 0 of 227
            Pseudo Genes (frameshifted)       :: 94 of 227
            Pseudo Genes (incomplete)         :: 145 of 227
            Pseudo Genes (internal stop)      :: 69 of 227
            Pseudo Genes (multiple problems)  :: 62 of 227
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:28:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2712180
            Orig. end                         :: 2737419
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031749.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="11"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            295..1221
                     /gene="bla"
                     /locus_tag="DPQ26_RS13530"
                     /old_locus_tag="DPQ26_13920"
     CDS             295..1221
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="DPQ26_RS13530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13920"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_142330558.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALHVEAKEKTGQVK
                     HKNQAMHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEASYDNQLIAEATEVIVKALR"
     gene            1482..2324
                     /locus_tag="DPQ26_RS13535"
                     /old_locus_tag="DPQ26_13925"
     CDS             1482..2324
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="DPQ26_RS13535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13925"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727189.1"
                     /sec_met_domain="Metallophos_2 (E-value: 9.1e-08, bitscore:
                     30.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2540..2791
                     /locus_tag="DPQ26_RS13540"
                     /old_locus_tag="DPQ26_13930"
     CDS             2540..2791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="DPQ26_RS13540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13930"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2980..3705
                     /locus_tag="DPQ26_RS13545"
                     /old_locus_tag="DPQ26_13935"
     CDS             2980..3705
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="DPQ26_RS13545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13935"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187074.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVPS"
     gene            3702..4721
                     /locus_tag="DPQ26_RS13550"
                     /old_locus_tag="DPQ26_13940"
     CDS             3702..4721
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="DPQ26_RS13550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13940"
                     /product="ABC transporter permease"
                     /protein_id="WP_098578263.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKMMKNQEASIYEYSKEKAISELEKQKVDAVFRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNFLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFIRERLSGTLERLLSTPIRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            4746..5399
                     /locus_tag="DPQ26_RS13555"
                     /old_locus_tag="DPQ26_13945"
     CDS             4746..5399
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168191.1"
                     /locus_tag="DPQ26_RS13555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13945"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_016512809.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYERLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRF"
     gene            complement(5521..5820)
                     /locus_tag="DPQ26_RS13560"
                     /old_locus_tag="DPQ26_13950"
     CDS             complement(5521..5820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="DPQ26_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13950"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_061660872.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLTLSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNINTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6054..7022
                     /locus_tag="DPQ26_RS13565"
                     /old_locus_tag="DPQ26_13955"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="DPQ26_RS13565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13955"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_001248644.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTISDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKNFSYLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKELVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="DPQ26_RS13570"
                     /old_locus_tag="DPQ26_13960"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="DPQ26_RS13570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13960"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397279.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.1e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.1e-57, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="DPQ26_RS13575"
                     /old_locus_tag="DPQ26_13965"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="DPQ26_RS13575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13965"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486742.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.9e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.9e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3.2e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 5.2e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="DPQ26_RS13580"
                     /old_locus_tag="DPQ26_13970"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="DPQ26_RS13580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13970"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="DPQ26_RS13585"
                     /old_locus_tag="DPQ26_13975"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="DPQ26_RS13585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13975"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775435.1"
                     /sec_met_domain="HMGL-like (E-value: 2.5e-47, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="DPQ26_RS13590"
                     /old_locus_tag="DPQ26_13980"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.6e-75. Score:
                     245.5. Matches aSDomain:
                     nrpspksdomains_DPQ26_RS13590_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="DPQ26_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13980"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939814.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLDELQTILTQI
                     SEDSNVRVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRIEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DPQ26_RS13590_ECH.1"
                     /evalue="1.60E-75"
                     /label="DPQ26_RS13590_ECH.1"
                     /locus_tag="DPQ26_RS13590"
                     /protein_end="254"
                     /protein_start="14"
                     /score="245.5"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLDELQTILTQISEDSNVRVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRIEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="DPQ26_RS13595"
                     /old_locus_tag="DPQ26_13985"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="DPQ26_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13985"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886744.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="DPQ26_RS13600"
                     /old_locus_tag="DPQ26_13990"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 3.9e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_DPQ26_RS13600_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="DPQ26_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_13990"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806506.1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-88, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYSWMKSLGYEDYETFYNKSIEETAWLW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFAVLREGVIFTEDLKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DPQ26_RS13600_AMP-binding.1"
                     /evalue="3.90E-82"
                     /label="DPQ26_RS13600_AMP-binding.1"
                     /locus_tag="DPQ26_RS13600"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DPQ26_RS13600_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="DPQ26_RS13600"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DPQ26_RS13600_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="DPQ26_RS13600"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15558..16001)
                     /locus_tag="DPQ26_RS13605"
                     /old_locus_tag="DPQ26_13995"
     CDS             complement(15558..16001)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DPQ26_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DPQ26_13995"
                     /product="hypothetical protein"
                     /protein_id="WP_208755845.1"
                     /transl_table=11
                     /translation="MKGGRNECLGKMIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSI
                     VMMIGGNLKKSVIVTMIGGNLKKSVIVTMIGGNLKKSVIVTMIGVLNEISVVVNVSLFV
                     AIVKEKIGNFFNVNVKKKIWLLEPIGLFRKVNPTPTSLLSLNF"
     gene            16568..16924
                     /locus_tag="DPQ26_RS13610"
                     /old_locus_tag="DPQ26_14000"
     CDS             16568..16924
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="DPQ26_RS13610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14000"
                     /product="hypothetical protein"
                     /protein_id="WP_000535572.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDLVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    16939..16954
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            17030..17563
                     /locus_tag="DPQ26_RS13615"
                     /old_locus_tag="DPQ26_14005"
     CDS             17030..17563
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002163646.1"
                     /locus_tag="DPQ26_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14005"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000990084.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLESFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEVTSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAIFCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            complement(17835..18443)
                     /locus_tag="DPQ26_RS13620"
                     /old_locus_tag="DPQ26_14010"
     CDS             complement(17835..18443)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="DPQ26_RS13620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14010"
                     /product="hypothetical protein"
                     /protein_id="WP_000136050.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTNFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLPFECFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(19052..19189)
                     /locus_tag="DPQ26_RS13625"
                     /old_locus_tag="DPQ26_14015"
     CDS             complement(19052..19189)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="DPQ26_RS13625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14015"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     gene            <19371..19460
                     /locus_tag="DPQ26_RS13630"
                     /old_locus_tag="DPQ26_14020"
                     /pseudo=""
     CDS             <19371..19460
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="DPQ26_RS13630"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14020"
                     /product="DNA damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEIHHIGQLSIWARQLNLQPVSANLIGRG"
     gene            complement(19522..20538)
                     /locus_tag="DPQ26_RS13635"
                     /old_locus_tag="DPQ26_14025"
     CDS             complement(19522..20538)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="DPQ26_RS13635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14025"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_001160048.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSAALSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTVLMNKKAKELKLLQPSPFLNS
                     TGINNDTNKQSTTTAIDVAKLAARLIKDFPDVLNITKLTSYQFSFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLEDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(20714..21871)
                     /locus_tag="DPQ26_RS13640"
                     /old_locus_tag="DPQ26_14030"
     CDS             complement(20714..21871)
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001243314.1"
                     /locus_tag="DPQ26_RS13640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14030"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_098425356.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGVKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYET
                     CIKKMIEEIRYIANGNFNHKVSVVNHNYLEELAIGINEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKG"
     gene            complement(21861..22556)
                     /locus_tag="DPQ26_RS13645"
                     /old_locus_tag="DPQ26_14035"
     CDS             complement(21861..22556)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="DPQ26_RS13645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14035"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038808.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKFIHTV
                     WGVGYKIEK"
     gene            22749..23357
                     /gene="yqeK"
                     /locus_tag="DPQ26_RS13650"
                     /old_locus_tag="DPQ26_14040"
     CDS             22749..23357
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="DPQ26_RS13650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14040"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_098506502.1"
                     /transl_table=11
                     /translation="MLYNDIYSFAPTGKIDNDIKDFLLKYNKEFTYKHSIRVANKAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIEEAERKFPMIIHQKLSRVI
                     AKEIFKVEDEDVLDAICCHTTLRKHPTKMDLVLFVADKIEWDQKGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWYLKRIVQ"
     gene            23371..24189
                     /locus_tag="DPQ26_RS30645"
                     /pseudo=""
     CDS             23371..24189
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="DPQ26_RS30645"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3885 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLVPYLYSQWENHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENTKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADLSRYLPGSKTPTSKFSESKEGRWGAGCP"
     gene            24186..24923
                     /locus_tag="DPQ26_RS13665"
                     /old_locus_tag="DPQ26_14055"
     CDS             24186..24923
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="DPQ26_RS13665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_14055"
                     /product="S-adenosylhomocysteine nucleosidase"
                     /protein_id="WP_002082744.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRLYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
ORIGIN
        1 tagatgtata ctttgattta aaacagcaac gtatacatgg tgaagctact agtacaggta
       61 gttctaagca aaattagagt acttttctca gggaaagaac ctgttcatat aaagccattt
      121 ataagtaaaa aaatgaaata tgaaatagga gatagaggcg tcgtagctac tatctcttat
      181 tttgttaata actctcatac tagctataat ttttttagtt tatggaacaa atttggttcg
      241 gtgattgtct attatgtgta cgtataaaaa ggtgctaaaa atttggaagg aatgatgatt
      301 ttgaaaaata agaggatgct aaaaatagga atatgcgttg gtatattagg tttaagtatt
      361 acaagcctag aagcttttac aggaggggca ctgcacgttg aagcgaaaga aaagactgga
      421 caagtgaaac ataaaaatca ggcgatgcat aaagagttct ctcaacttga gaaaaaattt
      481 gatgctcgag taggtgtata tgcgattgat actggtacaa atcaaacaat ttcttatcga
      541 tctaacgaaa gatttgcctt cgcatcaacc tacaaggctt tagcagcagg agtattacta
      601 cagcaaaact caattgatac attaaatgaa gtaatcacat ttacgaaaga agacttagtg
      661 gattattcac ctgttacaga gaaacatgta gatactggaa tgaaactagg agaaattgct
      721 gaggctgctg ttcgttcaag tgataatact gcagggaaca ttttatttaa taaaataggc
      781 ggacctaaag gatatgaaaa agcgcttaga aagatggggg atcgggttac tatgtctgat
      841 cgctttgaaa cagaattaaa cgaagctatt ccaggagaca ttcgtgacac tagtacagcg
      901 aaagcaattg ctacgaatct taaagctttt acggtcggaa atgcacttcc agctgaaaaa
      961 cgtaaaattc ttacagagtg gatgaaagga aatgctacag gggacaaact tattcgtgca
     1021 ggcgtaccaa ctgactgggt agttggagat aaatcaggtg ctggcagtta cggaacaaga
     1081 aatgatattg ctatcgtttg gcctccgaat agagcaccaa ttatcatcgc aattttatct
     1141 agtaaagatg agaaagaggc tagctatgat aatcaactca ttgcagaggc aacggaagtt
     1201 atagttaagg ctcttaggta atagtatttt agttttcgca tttttaacat aaaagtatta
     1261 aaagtataaa gttagaaaac gactcttttc gtgtgataag agtcgttttt gtgttcttat
     1321 tattaaaaag gtaaaagtaa aaatataacg aatatatatg acgtatctca tatgaaattt
     1381 tctgtactgt attattttat taatttaaat aaatttcaag aaagtataat ataattcagt
     1441 tagcatatag aagtgtttga tgagaatata aaggagaaaa tatgaaaaaa aagattaata
     1501 gaatcgtaat gattatttgt atattagtag gttttacaat ctttttatat ttacagaaca
     1561 atttaataag tataactgag gttaaaataa cctctagtaa aataccatcc tcttttaaag
     1621 ggtataaaat tctacaaatt tcagacttac acaataaaaa atttggcgat aatcaagatg
     1681 tgttaattca aaaaataaaa agtatagacc cagatattat tgcgattacg ggtgatttaa
     1741 ttgacagtaa atcatacgat gcagaagtta gtatgcaatt aatacgagaa attgtaaaga
     1801 aatatcctgt atattttgtg acaggaaacc atgaacaatg gtctggaaag tataacaatt
     1861 tagaaaaaga gttgaagaaa tatgatgtca atgttttaag gaatgaacat gtaggcattc
     1921 gaaagggtga gcaagaaata aacttgctag gtattgatga tccagagttt gttactggaa
     1981 accgtgatga aggaaatatt ataatagatg aaattaaaaa agcgaaaatt gaaatgcagc
     2041 cagataaata taatgtatta ttatcccatc ggcctgaatt tataaaggaa tatacgaatg
     2101 agaggttgga tttggtttta tcgggacatg ctcatggagg gcaagttaga ttgccattta
     2161 tcggaggatt agttgcgcca aatcaaggtg ttttacctaa atatacagcg ggtttatatg
     2221 tagaacaaaa tacatcaatg gtagtgagta gaggattagg aaatagtatc attccgcaaa
     2281 ggattttgaa taggccagaa attgtagtcg tgcagctaaa ttaagctgta cgattttttt
     2341 tatacaaaaa tgagtaaagg ggctttctgt attttgcagg agtaaacatt acaattttgt
     2401 taaaaatttt ctacgttaca taaagtaaca aaatttgacc ctcagtgttt gttatagtgt
     2461 aaataatcaa aaaacttaaa atttgtcgag tgaaaattgt gataagtaat tcatataaaa
     2521 aacttaaagg ggtgtacaca tgcataaaga atatgaaatt gaagaataca cggcgattga
     2581 ggaacaaatc cattattatt gtaaatgttt attagtaagt catcctgatc aaataataaa
     2641 gtatttagaa aaaaggttag aaaaatatgc agaaacatta caatatgcac atttatatcc
     2701 tgacacagtt attttaccgt tacagcaatt agttatcgaa tattctttag acgttgctag
     2761 aattcggaag tatatgaatt taaaaacgta aagtgaaatt tatagtttaa atgaaccaga
     2821 gtcgacttta ggaaatgaaa ttctaatgtc gactctgttt cattttttaa tatcggtgat
     2881 tgaacataca tactaatcaa cgaagtttga catataatta agcaagagta aaataaaagt
     2941 gagtactcac tcatttttat tggaaaagga ggatgaaacg tgcaacaacc ttcaattatt
     3001 ttacggactg tatcaaaaag ttttggaaaa aaagaagtgt tacacaatct ttcattgcaa
     3061 gttgaaaaag cagagatttt tggttttgtt ggaccttctg gatcggggaa aacaacgctc
     3121 attaaaatga ttgcaggtat taatgaggca acgaaaggtg aagtgcttgt taataatact
     3181 aatatgccta atttaaatga aatgaaacga attggttata tggcccaggc ggatgcatta
     3241 tatgaagaat tgtcagcata tgaaaatgca gattttatag caacgatgta tggattaaag
     3301 ggaaaaagta aaaagacaag aattgcagag gtttttgaac ttgtacaatt gtcacagtat
     3361 atgaaaaagc aagtacaaca attttcaggt ggaatgaaaa aacgcttatc attagcaata
     3421 gcactcctcc atgaaccaga aatattaatt ttagatgagc ctacagtggg gatagatccg
     3481 cttcttagga aaacgatttg ggaaaaattt tatgatctta aaaagaaagg cacaacgatt
     3541 attgtaacga cgcacattat ggatgaagct gaattttgtg agcgtctagg attaattaga
     3601 gaagggaaac tagttgcggt tggaacaact gaagaattga aaaaacgcgt gtcatctgga
     3661 cggattgaag atgtcttttt gctggaagag gtggtgccat catgagagtt actggtgtaa
     3721 ttatacgtat tattcgtcaa ttttttcgag ataagcgttc gttagcaatg atgtttggag
     3781 caccgatgtt attactttgg cttttgtcac tagtgtttac acagaaagac tatataccgc
     3841 aaattgctgt tgttgatatg cctgctcaaa tagtaaaaat gatgaaaaat caagaagcgt
     3901 caatttatga atacagtaag gaaaaggcga tttctgagtt ggaaaaacaa aaggtagatg
     3961 cagtatttcg tatagagaat ggaaaaatga aacttctgtt ggaaggtagt gattcgtcaa
     4021 aaaatcgtgc tgtacttcaa gtattgcaaa aaagcacaga gaagaatgat gtatcgatta
     4081 tgaaacctga agtaaatttt ttacatggct ctaaagactt tacgatgttt gatgggcttg
     4141 gtcctgtatt aattggtttc tttacatttt tctttgtatt tatattatca ggtgtatcct
     4201 tcataagaga acgtttaagt ggtacgctag aaaggttatt atccactcca ataagaagat
     4261 gggaaatagt cgcaggttat attattggtt ttggaatctt tgcctttata caatccatta
     4321 ttatcgtaag tttttccgtt tatattttag atttatacgt agctggctct atatggctaa
     4381 cgctacttat tacatgtatg ctctctttaa ctgcactaac attaggtacg tttttatcgg
     4441 catacgcaaa taatgaattt caaatgattc aatttatacc gcttgttatt gtgccacaaa
     4501 tcttcttttc tggattgttt ccaatggaat ctatgaacaa gtggctacaa atgttaggga
     4561 aagtatttcc actcacatac ggcgctgacg caatgagaca agtgatgatt cggaatcaag
     4621 ggtttacaga gattgcatta gatcttactg tattattact tttttcaata ttatttgcag
     4681 taggaaatgt atttgcttta aagaaacatc gcaaaatata ataatgacaa aaaggagctt
     4741 tataaatgca gaaggattgg ctggaggaat taatagctgc aactaatacg gataaaagaa
     4801 atgaacgtca aatgcgaata ttagaggcgg ctgttgatat gtttggagaa aaaggatacg
     4861 cttcaacttc aacaagtgaa attgcaaaac gggctggtgt agcggaagga acaatcttcc
     4921 gctactataa gacgaaaaaa gatttattac tagcggtcgt aatgccaact ttaactaagt
     4981 tcgctgcacc atttttcgta caaacctttg caaaagaaat atttaaatcg gagtatgaat
     5041 catatgaaag acttttaagg gttgtaattc ataataggtt taaatttgct caaaaacact
     5101 ttcctatgat aaaaatatta attcaagagg tgccattcca accagaactg aaaaatgaaa
     5161 tacagcaatt agtagaaaca gaactgtttt cacatttcaa aaagttgatt gtgaaatttc
     5221 aagaagaagg ggaaattatt gagataccac catcttccgt actacgtctt actttatcag
     5281 ctgtattagg tttattatta acacgatttt tattattgcc tgaagaaaaa tggaatgatg
     5341 aagcggaaat tgaaaatacg attcaattta tattgtatgg attaactcca cgattttaat
     5401 cgttgaagtg tgaattacat acattacttt taagtaaaaa taaatcgcct ttaaaaaggc
     5461 gatttatttt cattatatat ttttgataaa taagtgcttg tttactaaaa acattctaaa
     5521 tcagcgtgtt tctttgtctc ttcttctaag acctaataat cctgctagtc ctaataaacc
     5581 aagccaagcc caattattat ttttatcacg attatcattt aaatcatttg ttgtatttat
     5641 atttcgagtt cttacatcat tattaactct gtctaagtta ttgtcattta ctcgagttga
     5701 aatatcagtg ttattaactc tattcatatt atttccatcg tattcagctt gcgtagatgt
     5761 acctaaaaac ataatagata gtgttaaaac actcaaaata gatgataatt tctttttcat
     5821 aacaatccct cctttcttaa tcattaattt ctccgaagca tgtgtgtatt attcatttca
     5881 caatatctaa accctcatta atagggcgca catttataga aaatagagtt gaatgattgt
     5941 taatgtatca ttggatttat atttctcata aaaataactg aatcaaactt tgcttaaaat
     6001 gttaatctta gtacaattta tattatacgg actagtaata aggaggtaat aagatgcgac
     6061 aatttgcaaa acctacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagagat gattccagat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg ggactcctcg tgaaacgata cgaattgtag
     6241 aagaaaatgg tgagaataga cttgtgcaac cgtcgacacg agaagatgta actgaaaaaa
     6301 tggaacagtt ttcaaatgac tttttacaaa cgatatcgga tgtggatggt tttattttaa
     6361 agaatcgttc accaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa gggaaaagga gctggcttat ttggcggagc agtagtaaaa aatttttcgt
     6481 atcttcctat tgaagaggaa ggtagattgt cgaattttat tattagagag catttcttta
     6541 caaggctatt tacaatcgca tattacaaaa tgattaaaca caataaaaat atgaaagaac
     6601 ttgtatcgtt tcagtcggat aataaatatt tatttatggc atataatcag gtgaaacaaa
     6661 aggaattagg tcgtataatt gcaaatcaaa aaaatgaaaa gattgaagtg gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgtgcgcc ccgttataca tcgaatgtaa
     6781 atgtatgcga gcacattttt ggatatttta aaacaaagtt aaaaaaacaa gaaaaagatc
     6841 attttataga actgttacaa aagtatgcag aaaagaaaat accacttagt agtttactta
     6901 caattttaaa atcatgggct attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata tcctgaagca ttagtagaaa tttctgattc cggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattctt gtcttttaag ttgttatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattact aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacagtat
     7441 cgtatgcttt agcagttgaa gaaattggtc gcgcttgtgg tggcaccggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaagtattt agttccaatg gcgtcaggta aaacattagg tgccttcgga ttaacggagc
     7621 cgaatgctgg atcagatgca ggtggtactc aaacgaaagc ggtattagat ggtgatgagt
     7681 atgtaatcag tggtgagaag tgttggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctgt caacggtatt gaagagaatg gtagaaaacg tatttctgca tttatcgtgc
     7801 ctactacgag tgaaggatta acgatttcaa gtccttacga taagatgggt gttcgcgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg ttcgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggctttaaa caatttttat atacacttga tggagggcgt atttcaatcg
     7981 ctgcattggc agttggtatt gcgcaatcag cctttgaacg tgcattacaa tatgcgaaag
     8041 aacgtcaaca atttggaaag tcaatctcta attttcaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagag ctagcacgca atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggc aaagaagcgg caatggcaaa actatttgca tcggaagcag
     8221 caagccgtat tgcgaatcaa gcagtacaga ttcatggtgg atatggttat atgcgtgaat
     8281 atgaagttga acgacatatt cgtgatgcga aactattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaggga ggaatcacta
     8401 tgtttcaaaa aatattaatt gcgaatcgcg gggaaattgc tgttcgtatt atgaaaactt
     8461 gtcaaaaact tggcatacgc actgttgcta tttattctga agcagatgaa aatgcccttc
     8521 atgtgaagat ggcaaatgaa gcttacttag taggtggacc gcgtgttcaa gaaagttatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgcagaagcg attcatccgg
     8641 gttatggttt attatcagag aatccgtctt ttccggttcg ttgcaaagaa gaaggaatcg
     8701 tatttatcgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatc gaatcacgta
     8761 tcgcaatgca agcagcagat gtcccagtag tcccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc cttaatgctt aaggcatccg
     8881 caggcggcgg aggcattggt atgcagttga tggaaactga gcaaacgctc accaaagcgt
     8941 ttgaaagtaa taaaacaaga gcgcaaaact tctttggtaa cggagaaatg tatttagagc
     9001 gatatatagc agatgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtattt atgggagcgt gaatgttcgg tacagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc accattttta gatgaaggta cacgaaaggc gatgggagaa gttgctgtac
     9181 aagctgccaa agcacttggc tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaagaactt ctatttctta gagatgaata cgagattaca agtagagcat ccagtgacag
     9301 aagaaattac gggattagac cttgtagaac agcaactcct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagct cgtatttatg
     9421 cagaggatcc gaaaacattc ttcccatcac ctgggaaaat tacagattta acattaccgt
     9481 caaatgtacg gattgatcac ttcttagaaa atcatgtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtcatt gcacatggcg agactcgtga agaagcaatt tcgaaattac
     9601 atgatgctct agaagaatta aaagtagaag gtattaaaac gaacacgcca atgctactgc
     9661 aagttttgga agacgaagtg ttcaaagagg gtatttatac aacggggttt gtaacgaaac
     9721 aactcgttaa aaaataagat ttaacaatat taagggggaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attattagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccaa aatgggtccc tgcattagca gatgcaaatg atgtattttc
    10201 tgagctgaaa agggatccaa atgttacata tgctgcgctt gttccgaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcgat taaagaagca ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg aagggaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgtcac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcaa atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctagc gaatgtagtt aaatcattag aatacggtat
    10681 taaaacgttt gatagttctt gtggtggact cgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aagttaggag tccaaacgaa
    10801 tattgatgaa gagaagttat tgagagcaag tcaatttatt caaagtaaat taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgattatg taacacctca cgttgtaaag atttcgttat
    10981 atcgtgaaag acaagcaaac tcattatctt tagcattatt agatgaatta caaactatat
    11041 taactcaaat aagtgaagat tcaaacgtgc gtgtagttat tttgactggt gctggtgaaa
    11101 aagcattttg tgctggtgca gatttaaaag agcgtgccga tatgaacgaa gaacaagttc
    11161 gccatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatgga attgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tctgcaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc aggtggtaca cagcgcttac cgagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatac ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg accgattgct gttcgattag caaaagaggc aatttcaaat ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatcgaat agaaggatta caggcattca aagaaaaacg caaaccgatg tataaggggg
    11701 agtaaatatg ttagaccaaa aacaacaatc taattcattt gaagaacgag ttgaaacaat
    11761 taaacaaggc ggggcaccga aatatcatga gcaaaataaa gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taactgtgaa caaacaggct tacctgcgga tggcgttgta acggcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggccaatga ttctactgta aaagctggat catggggatc
    12001 acgcacagtt gaaaagattt tacgtattca agaaacagct gaaaaactac gtgttccgtt
    12061 attttattta gtcgactctg ctggagcacg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcaggaagaa tcttctataa tcaagtaaag ttatcaggta aagttcctca
    12181 agtatgcttg ttatttggac cttctgcagc tggtggtgcg tatattccag ccttttgtga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtaaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggcgtatta ttccatgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgacgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgatcg gtacaaaagt agagcgtgct ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcgac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggc gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgttt
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtta atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgtgct agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatattta tcatttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtacaaggaa aaaacacgtt tatatagttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggctt tggggagagg
    13441 cagaaaaagc agttggctat caatggatga aaccttatac agaagtgtta gatttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagagacaa gaatacagcc agcacttcag tacgaaggag
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga taactgggta agccgtgttg
    13681 ccaatggttt gaaacacgcg ggtattgaaa aaggtgaccg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aattggagca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag ttatgacacg tgtgcaagcg gcaggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgcggtaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agttgttatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgag gaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccgtttc tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcgccaac gttaatccga gcattaatgg
    14401 caaaaggtga tgagtatgtc aataaacatt ctttaaagag tttggaagta ttcgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 atgttccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggcaatg
    14581 ttcttattaa gccaatcgca ccgattagtt ttaacgcatc tttaccagga atggcagctg
    14641 tcgtactgga tgatcaaggt aaaccaattc gagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtaaacacat
    14761 attggtcgcg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataacgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga cgaagtgaaa ggtgaagttt gtcattgctt tgctgtatta cgagaagggg
    15001 taatatttac agaagattta aagaaagaat taatgagttt agtaaactca catattggaa
    15061 aagcgttgtg tcctaaagac atccacgttg tagaagattt accgaaaaca cgtaattcta
    15121 aagtaatgcg ccgtgttatt aaagcagctt atttaggaaa agaattaggt gatttgtcgt
    15181 cacttgtaaa tcctgaagta gtaccgttta ttcaggggtt acagtctagt aaattataaa
    15241 attagaaagg agctctatat aaacagagct ccttttttat gttaataaaa agaaaagaag
    15301 tgaatttgat gaagaagaaa aattctacta ttggtgttaa gtatgttttt tgttttaatc
    15361 aaaatacgat attatggaat gtctactcaa tggagaaata ctaatttaca acaaggtgat
    15421 aacaaagcgt gcctgcttta tatgtctgtt aaaactttta cgtgttaata tataaaaagc
    15481 tgactatact cagtcagctt tttatatatt acattctagt atttatttca ctatttgccg
    15541 ggcagtaatg cccccaccta aaaattcagc gaaagtaagg aagtaggtgt gggattaact
    15601 ttccggaaaa gcccgattgg ttccaaaagc catatttttt tctttacgtt gacattaaaa
    15661 aaattaccaa ttttttcttt tacaatggca acaaataaag aaacatttac aacgacactt
    15721 atttcgttta gaaccccaat catcgtcacg atgacacttt tctttagatt tccaccaatc
    15781 atcgtcacga tgacactttt ctttagattt ccaccaatca tcgtcacgat gacacttttc
    15841 tttagatttc caccaatcat cattacaatg ctttttctga gaactccaat catcatcaca
    15901 atgatgcttt tctttagatt tccaccaatc atcacaacaa tgctttttct gagaactcca
    15961 gcaatcattt ttccaagaca ttcatttcta cctcctttca atagtgttca tattattcta
    16021 tgttttaata aaaaaatggc ttgtttatta acctactatt ttatctttat atgatagagt
    16081 gttttctact cgatatagag ttcatacaaa ccatgctaat ttttaagaga tagtggagag
    16141 aactactact agttatggtg ttttccaata aacatttgtt gaagaaagcg ttctgattac
    16201 aaataatatc ttattttcga gtacgctttt ttaaatgtat atttcacaat aacaaaggaa
    16261 aaatccacaa ataaagtcta tgtatatgtg agttaatgga aaaatctagt gtgtttttaa
    16321 ggtgcgtctt atttaaaaga aaaaagattt gttttagaaa gtggtgtcta aacattaaat
    16381 ggagtaggac taaattcacg gccgctcatt aaacaagctt ttaattagga gaagtctgtt
    16441 tttataatga ataatgaaaa gaaagtatag tacaattgtt tgtttttttt ctttttatgt
    16501 gtttgcctcg taccctttta agctagtgga catactttac taatagaaag gattaggggg
    16561 tgaggtattg ggttctcgat ttaataattg taaaaagaag tgtacatgta aacaagatga
    16621 ttgttgggaa gtattcgaag agtgtaaaaa agaacagcat gagaaatgtg ataattcttg
    16681 tgtacaagga attagagatg aacttaagaa attaattaat cgaacagttc aaattaatac
    16741 agagggacgt acttatgtag gtactgtttc gtctgtaagt tgtgatctag ttaggcttgc
    16801 ggctattcct ggatcggttg gagtaattat ttccatttgt aaaattgaag caattttccc
    16861 acctgttaca acggttactg ctgactttga ttttaatggt attgatgtag caaacaaagc
    16921 ataattatgc tgcttttttg taaagccatt cacatgaatg gctttatttt aatttcatat
    16981 aaaaggagaa tatattcttt atatagaaat aagtttgagg ttataaagca tgatgtatga
    17041 aaggagcaag gaagtgatta aactagaaag ctttaagaaa tctgatttta aacaattaat
    17101 aaattggatt aactccgaag aatttctaat acaatggtca ggaaatgcat tcacattccc
    17161 tttagacgaa cagcaattag agaagtatat agaaagtgca aatacactcg ctttcaaagt
    17221 ggtagatgaa gtgacttcag acgttattgg tcatatttcg cttgggcaaa tagataatat
    17281 taataagtcc gctagaattg gaaaagtatt agttggtaat acgaagatga gaggacgttc
    17341 tataggaaaa catatgatga aagcagtact tcatattgct tttgacgaat taaaactaca
    17401 tagggtaact cttggtgtgt acgattttaa tacatcggcc attttctgtt acgaaaaaat
    17461 agggtttgta aaagaaggct tattaagaga gtcaaaaaga gtaggagaaa cgtattggaa
    17521 tttatgggaa atgagtatgt tagaatatga atggaagaag tagcaacaat agtaatttat
    17581 aattatatta tgttaacaaa aggggcttgg tgggtatagt ggataataaa acaaaaataa
    17641 tttcaattgc agctgtttca gggggagagc tagtatatta aaactgacaa agaaaccatt
    17701 tttgaaaaag gcccacctgc attgtttctg aggaataaga gggtgagccc taattaaacg
    17761 aaactgaatg aatctgtaaa aattgtaact aaagtatgca tcaacaaggt attgaaaggg
    17821 atgaatagta aactttacag attattccat atgtaacaaa actggttagc ttctgattta
    17881 agcgctacta aatgattatt attaatagag ttattcgtat acattctgtt cttttggatg
    17941 ttaagtaccg tataattcac atcgtttcgt tcatttgaaa atgttgattc atttaatagt
    18001 gtaagtgtcg agttaatgtt gtatttatca attcgctctt tttttccttt gaaaaacagt
    18061 ttgataagat gtggctcatt attaatgaat aagccaagtt caggtgatga acggacgatt
    18121 aaatcatctg atttccaatg tgatttacct ggatcaaacc aggagatgtc tttattttta
    18181 atgaattttt tgtattgctt tataacatca atgtagtttt gttttttttt ctgatcaacc
    18241 gtttgtacta atgtttcgaa acattcaaaa ggtagtttgt tttgatgaaa tttaataaca
    18301 gtttctcgta attgtttcca gtaatcaaaa gctggttgat attcaggttg ggattttaga
    18361 ttttttataa agtttgtttt agctgtacta cctttcagtg tgaagtctaa aaattgtgta
    18421 agccctactt taatttctgt catattacat cacccttcca aacattattc atttaataat
    18481 agacgaaata ccctacattt ttaaagaaat gagctagatg ctagaaaacc taatgtccat
    18541 gcacaataga tacgggaaag ccaatccgta agtataaatg atggaccatc caattgaaga
    18601 taaattagat aatggttacc aggtgatagg ttattaatat aatcggatag tgaggcgagt
    18661 ttaaaagata acaatataga ttatttagct tggatttgag aaaaaagtgc atgggaataa
    18721 agagggatat agggaaatgg gctctcatca aaaaatataa gttggtatca gtataccgta
    18781 gagaatgagt gtatagaaca tacaagtaaa agtattggct agcacactta aaataagccg
    18841 tataaaaagt taatcatcgt gtgctttgat tatataatgt cggcgaaata aatagtgtga
    18901 aggacagcga tcttaacaag tgtttcatgt aacgttcatg tactttaatt ttttataatt
    18961 aatcaaattt gaattttgtt tgttgttaag aaaaggtgag aagaaaataa aaaaagaggg
    19021 ctaatgccct ctttttttat taatttggta attaatcaca gattggtatc ccaagcactc
    19081 ttagagctaa tgctacttga agggaaatct ctaatctagc aatttcaata ccagctactg
    19141 aaagaactaa aaaaggttgt ccgtttacaa atacaacgca actatccata gttaagcctc
    19201 ctttctagta atctactata gtatatgaat agaactttaa tatgtaatag ttaaattgtt
    19261 ggatttaata gaattaatag attaacccat ttaaactaaa caaacgaaca caatgaacgg
    19321 aaacagagat gggtgtatgc ctcgaaaaac ataggtttta agacatggga tatgaaattc
    19381 atcatattgg tcagctgtct atatgggcga ggcagttaaa cttgcaacca gtttcagcaa
    19441 atttaattgg aagaggataa tagaattaaa aaccgacttg catctcaaac gcaagtcggt
    19501 ttttatatat aagaagattt cttaattgaa atcctcggat tttttctgac gtatatgtaa
    19561 aaacattaag gtggtaatga ttaaaaaaat cattatagtt tgtataatta aatttttaaa
    19621 ctgaagcaat attgtccacg atgtaagggt gtctttaaaa gcttggagtg cagagtacga
    19681 ggaaggatca aaaccatact gtagcaactt ttttgtttca ataaatgaaa tgttttcttc
    19741 atctgcatct aatattactg aaattagtct agtatcttca agttttgctg tactgacaaa
    19801 actataatta ccattagttg aaaaactagt ttgtaagcca tcaacacctt gaagtttaat
    19861 gttttcatta agggaatata tcattttatt cgtattgaaa acctgggaat ctttgaagga
    19921 aaattggtaa gaggttagtt tcgtaatatt caatacatct ggaaaatctt ttattaatcg
    19981 tgctgctaat ttagctacgt ctattgctgt tgtagttgat tgtttatttg tatcattatt
    20041 aattccagta gagtttagaa atggagatgg ttgtaataac tttagttctt ttgctttttt
    20101 attcattaat actgtaaagt tatcttcatt tccagcaatg tgttctgcaa gagcgagtgc
    20161 agaacgatta ttccctgcca gtagcaatgc atgaagtaaa tcacgaaccg ttgttttatc
    20221 attcgatgtt acttgtatag ggcttgtttc tactcggaat acttcgttac ttatttgtac
    20281 gaagtcatct aactgtattt ttctatcatt tagttgctcc aatacgatat attctgtcat
    20341 taatttagat aaagcagctg attgtactgg agtttcttca ttttttttat aaacaatttc
    20401 acctgaatta gcatttatta agatagctga tttagcttga ataatcggac catttacata
    20461 aaggtaaaaa tataaaacga taagtgcagt aatgaaaaaa gataataata aaatagcgaa
    20521 tttttttaag aattgcataa gcgatcctcc tattatgaca tcaataatag tattgtaaaa
    20581 aagaatgctt aattaggaag aaagaaaagg taaagaattt ctaaagaatt ataaaggatt
    20641 attaattttt tgtaattaat ggaaaaagtt caatttctta tatgataaga aattgaactt
    20701 tttatttgtg atattaacct ttgtagggga gtagttttac agtgaaagtt gttttttcgt
    20761 catcactata tacttcaatt gttcctttat gcaattcgac tatacttttt gcaattgcta
    20821 atccaagtcc agatccacca gtgtttgtag agcgcgattt ttcaacgcga taaaaacgtt
    20881 caaaaatatg aggtaaatcc gtactaggaa taggttgtcc gtaatttgtt atatcaattg
    20941 taatcatatt attgctttca taagcagtaa ggtcaatata gcgaccttcg cttccataag
    21001 cgatagcgtt tataataaga ttttcaaaca cacgcactaa tttgtcacca tcagctaata
    21061 ccatgagctt ttgagatggg aaagaaggtc tacattctat attagcttct tgaacctgta
    21121 ttcggaattg aacagttaat tgtccaagta actctacaat atcaatgggg acagaataca
    21181 agcttaactc tttattttga acacgtgtat attcgaacaa gtcattcatt aatgcattaa
    21241 gacgagttac tttatcataa atgacttgaa tatagtatcg caattccact tcatctctat
    21301 aattatcatg atgaattaaa tttacgtatc caactataga agtaagggga gtacgtaaat
    21361 catgtgatac atttgtaata agttcactct ttgcttgttc cgcttgtctt tcttcatcaa
    21421 ttgagacttt taattgttca acaatttcat tgatcccgat tgctaactct tccaaataat
    21481 tatgatttac aacagaaact ttatgattga agtttccatt tgcaatgtaa cgaatttctt
    21541 ctatcatttt ttttatacaa gtttcatagt aaagttttct ctcgtgacga taaaaaatgt
    21601 aaagatagga tgaaaaaata gaaaataaaa acaaataaga aacaatcatc atccataaag
    21661 attctttaac ccctttatac ttttcataac caaaaattcg aatgaattct ttaccgagct
    21721 cggttagagt aagtgaactt tcaattacac tcgtaacgag gcgataaata attaattcag
    21781 taataggagt gagtgtgata gctagtaaga gccaaaaaat aagtttccat ttagggatat
    21841 cttttaatat atcaaatgct tcatttctca attttatagc caactcccca aacagtgtga
    21901 ataaattttt ctccattcat taccgtttca agtttatccc gtaagttgct aatatggacc
    21961 attaccgtct tatttgaacc ataaccatct tcattccaaa cgcgttcgaa aatttcttct
    22021 gaactaaata ctcttcctgt attactcgca agtaaatata aaatatcgaa ttcaatagag
    22081 gttagtttaa tatactctcc atttacttta acagtatgat tatgtttgtg tatttcaaca
    22141 gagcgaatac gaataatacc atcttcattc ttttgcgaag tagcattttg gaaagatgat
    22201 cttcgtaata aagctttcac tctagctact aattctaatg gattgaatgg tttgatcata
    22261 taatcatcgg cacctgtcat aagacctaat attttatcca tatcttctgc ttttgcacta
    22321 agcattagaa ttggtacagt attattttca cgtacttcct gacaaacttc taatccgttt
    22381 cgttttggca tcataatatc caaaatcata aggtcaactt catatgtaga aaccttctgc
    22441 aatgcttcat cgccatcata agctttataa atgttatagc cttcatttcg caaataaaca
    22501 gcaagtaatt caacaatttc tttatcatca tcaataatta atatgttttt attcattttg
    22561 tagttccttt ccttacaaat catcaacatt actataatat caaacattta tgtacttgta
    22621 gcaatgattc tgtataaaat ttcatgtaac gtattaaaaa ggagtaaaaa gattaataac
    22681 gaatataaaa taacaaagat atttaaattc tgcattatac tgaaagttag ttataagggg
    22741 gattttctat gttatataat gatatatatt catttgctcc aactggaaaa atagacaatg
    22801 atattaaaga ttttctacta aaatataata aagagtttac atataaacat tcaattcgtg
    22861 tggcaaataa ggcaaaaaag attgcagaaa agtttcacgt agataaagaa aaagcagcaa
    22921 ttgcaggata tttacatgat attagtggca tttttccgaa cgaggagcgg attgcagttg
    22981 ctgaagaatt tggggtagaa atagaggaag cagaaagaaa gtttcctatg attattcatc
    23041 aaaaactatc gagagtaatc gcaaaagaaa tatttaaagt agaagatgaa gacgtattag
    23101 atgcaatttg ttgtcatact acactgcgta aacacccaac aaagatggat ttagttttat
    23161 ttgttgcaga taaaatagaa tgggatcaaa aggggacacc accatattta atagaaataa
    23221 aaaaaggatt ggaaaaatct ttggaaaaag ctgcttttgt atatatttca tatttgtggg
    23281 aaaggaaaga tacattgaaa gttatacatc cgtggctaga agaagcatat tggtatttaa
    23341 aaagaattgt acagtagaag ggacaaggaa atgcaattaa aagaatatat gaatcaaaca
    23401 tttccaggag ttacattagt accgtactta tattctcagt gggaaaatca tttgtatttt
    23461 gattttggaa aagataaata tcaaattgta gaaggaaccg acgatttaaa tatggaatac
    23521 ttttctcagc tatatacata taataaattc ttatttgaag acatattttc aaaagaagat
    23581 gtagtgtttg tagtgacaaa tgtttataga tttaaaaagg aaaacacaaa aactccacag
    23641 aaaataaatg tatacaataa atatattaag aaaagagatt taagatttca tataagacaa
    23701 gaaacgttac cgtttctatt tgaagatgaa gaggcagatt tatcccgcta tttgccgggc
    23761 agtaagaccc ccacctcaaa attcagcgaa agcaaagaag gtaggtgggg ggcgggctgc
    23821 ccctaaaagc ccgattggtg agggctgata atcagtgggg gatgaactga ttaaagtttc
    23881 acattatatt gtacatatca attttcttta aaatgtcttg cggaagatat taaatatgaa
    23941 tcgcttatac aagctgctaa tcatgaggat ttctctgttt tgtatcctcg atttggacgg
    24001 aaaaaagaaa tttcttatcc agatgtattt ctcataaatg caacgaaaga tattgtcatg
    24061 tttatgtatg atgatagagg atgtgaagta attgcgaaga ataaagaaat aatacgagat
    24121 ttatataaga aatataaaga atggattcca gattatgaac gagaaagtat agataactta
    24181 tttaaatgac aataggggaa gtgaagcgtg taatgaaacg tattgcaatt gtatctgcat
    24241 gggaaccaga actgacgtat ttgcatcaac attatccgag tgaacgtgtt gaaaaaagag
    24301 cagcttggga atttcatttt catactatca atgagctgga aattatatca gttgtaactg
    24361 gtgtcggtaa agtaagctgc gctagttgtg tacaattgtt aattagtgag tttcagccag
    24421 atgagttgtt tatgacagga atatgcggaa gtttatcaaa caaagtgaaa aacggtcata
    24481 ttgtagtagc actaaacgca atacaacacg atgttactgc tgctggctca ggagaagatg
    24541 tttttaattt atataacggt agaacagcac ctattgaaac aacaaaatca cttgtaagaa
    24601 gaataaaaaa aatacgattg tatgatccga tacatttcgg tacattttta tctggagatc
    24661 aacgtattcg tagttcagaa atgagatatt tacttcatac tgtatacgga gcattggcag
    24721 ttgatcaaga agtagcagct ttcgcctatg tgtgtcaaat aaataaaaaa ccatttttat
    24781 gtttaaaagc tgcttcagat caagcaaatg ataaaacgaa agaagaacaa aaaatcttta
    24841 aaatgctagc atgcgaaaga gcatgtgagc atttaattgc ttttttacgt gtttatgaga
    24901 ttaatgtagt aaataataga tagtttgtta taaaacaaat taatagtaag ttatatgtag
    24961 ggaaatgtcc gttcatttca aattaagagc tgaaatttat aatagatgga atatattata
    25021 tgggtacatg ttgagattaa tacaagcaat tggagggcaa ttttatatga ttcaatataa
    25081 aaggtgtagt gaagtaaata ttgatttagt atatgaagct tttaaagatg gattttccga
    25141 ttatattatt aagatggaag tttcaaaaga gggttttata caacgttttt ttggaccaga
    25201 aggtaatttg ctagaacatt cttttcttgc tttagacgg
//
